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Journal articles on the topic 'Immunohistochemistry; Squamous cell carcinoma; Type IV collagen'

Author: Grafiati

Published: 7 June 2025

Last updated: 16 July 2025

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1

Fatima, Ghazi Aswad. "Collagen Type IV Expression in Well, Moderate and Poorly Differentiated Squamous Cell Carcinoma of the Oral Cavity." Journal of Dental, Oral and Maxillofacial Research 2, no. 2 (2024): 01–07. https://doi.org/10.5281/zenodo.14011957.

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<strong>ABSTRACT</strong> <strong>Background: </strong>Squamous cell carcinoma(SCC) is the most important and common form of cancer of the oral cavity, Having a very high risk of local invasion, and nodal and distant metastases. Studying the mechanisms of invasion and metastasis of malignant cancers has had a crucial role in developing possible therapies tools. Type VI Collagen is expressed in a variety of tissues and abnormal expression is Related to the invasion and progression of different types of cancer in the body.  <strong>Aim: </strong>To assess whether th

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Massi, D., and A. Franchi. "Desmoplastic trichilemmoma: a case report with immunohistochemical characterization of the extracellular matrix components." Acta Dermato-Venereologica 77, no. 5 (1997): 347–49. http://dx.doi.org/10.2340/0001555577347349.

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The case of unusual desmoplastic variant of trichilemmoma arising in the neck of a 56-year-old man is reported. The tumour was characterized by the presence of a densely sclerotic stroma, surrounded by lobules of epithelial cells with features of outer root sheath differentiation, including glycogen-rich, clear cytoplasm and peripheral palisading. In the central part of the tumour, irregular cords of epithelial cells entrapped in the desmoplastic stroma were found. Differential diagnosis of this rare tumour includes invasive squamous cell carcinoma, morphealike type basal cell carcinoma, desmo

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Benediktus, Adrian, Soehartono Soehartono, and Hendradi Surjotomo. "Korelasi ekspresi LMP-1 dengan ekspresi E-chaderin dan MMP-9 pada mekanisme metastasis penderita KNF WHO tipe 3." Oto Rhino Laryngologica Indonesiana 49, no. 1 (2019): 40. http://dx.doi.org/10.32637/orli.v49i1.263.

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Latar belakang: Karsinoma nasofaring (KNF) adalah karsinoma sel skuamosa yang berasal dari epitel nasofaring. Salah satu etiologi KNF adalah infeksi Epstein-Barr virus (EBV). Pada biopsi jaringan KNF sering ditemukan genom EBV. Latent membran protein-1 (LMP-1) merupakan antigen dari EBV diekspresikan pada 65% KNF. Efek LMP-1 pada signaling salah satunya adalah memodulasi E-cadherin dan matrix metalloproteinase 9 (MMP-9) yang berperan pada proses metastasis. Metastasis adalah suatu proses yang kompleks dimana sel-sel kanker meninggalkan lokasi primer dan bermigrasi ke jaringan lain dalam tubuh.

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Hirota, Jyusui, Kazunori Yoneda, and Tokio Osaki. "Basement membrane type IV collagen in oral squamous cell carcinoma." Head & Neck 12, no. 5 (1990): 400–405. http://dx.doi.org/10.1002/hed.2880120505.

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5

Orlinskaya, N. Yu, D. V. Davydenko, I. L. Shlivko, and O. E. Garanina. "Setting of reliable immunohistochemical criteria for the recurrence of nodular basal cell carcinoma." CLINICAL AND EXPERIMENTAL MORPHOLOGY 9, no. 3 (2020): 43–49. http://dx.doi.org/10.31088/cem2020.9.3.43-49.

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Introduction. Basal cell carcinoma (BCC) is one of the most prevalent skin neoplasms with increasing incidence. The grade of BCC malignancy is highly variable and depends on the invasiveness and recur-rence potential. The study was aimed at identification of immunohistochemical (IHC) determinants of BCC recurrence. Materials and methods. The comparative study encompassed 10 cases of primary BCC and 10 cases of recurrent BCC. The panel of immunohistochemical targets included p53, CK8/18, Bcl-2, CK19, Collagen type IV, Desmin, CD8, Ki-67, Vimentin, VEGFR, EGFR and AR. Results. Diffuse expression

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6

Rivera, César. "Histological and molecular aspects of oral squamous cell carcinoma (Review)." Oncology Letters 8, no. 1 (2014): 7–11. https://doi.org/10.3892/ol.2014.2103.

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Oral squamous cell carcinoma (OSCC) represents 95% of all forms of head and neck cancer, and over the last decade its incidence has increased by 50%. Oral carcinogenesis is a multistage process, which simultaneously involves precancerous lesions, invasion and metastasis. Degradation of the cell cycle and the proliferation of malignant cells results in the loss of control mechanisms that ensure the normal function of tissues. The aim of the current review is to present the histopathological features of OSCC, including potentially malignant changes, the international classification of tumors, th

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Tamamura, Ryo, Hitoshi Nagatsuka, You-Jin Lee та ін. "Distribution of Collagen Type IV α1-6 Chains and MMP in Oral Squamous Cell Carcinoma". Journal of Hard Tissue Biology 13, № 3 (2004): 125–30. http://dx.doi.org/10.2485/jhtb.13.125.

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8

Nakagawa, Hideyuki, and Soroku Yagihashi. "Expression of Type IV Collagen and Its Degrading Enzymes in Squamous Cell Carcinoma of Lung." Japanese Journal of Cancer Research 85, no. 9 (1994): 934–38. http://dx.doi.org/10.1111/j.1349-7006.1994.tb02971.x.

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9

Tamamura, Ryo, Hitoshi Nagatsuka, Mehmet Gunduz, Hong Gong Liu, and Noriyuki Nagai. "Localization of Collagen Type IV Alpha Chains at the Basement Membrane of Oral Squamous Cell Carcinoma." Journal of Hard Tissue Biology 14, no. 2 (2005): 194–95. http://dx.doi.org/10.2485/jhtb.14.194.

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10

Van Duzer, Avery, Sachiko Taniguchi, Ajit Elhance, Takahiro Tsujikawa, and Naoki Oshimori. "ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival." Life Science Alliance 2, no. 6 (2019): e201900582. http://dx.doi.org/10.26508/lsa.201900582.

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Invasive squamous cell carcinoma (SCC) is aggressive cancer with a high risk of recurrence and metastasis, but the critical determinants of its progression remain elusive. Here, we identify ADAP1, a GTPase-activating protein (GAP) for ARF6 up-regulated in TGF-β-responding invasive tumor cells, as a strong predictor of poor survival in early-stage SCC patients. Using a mouse model of SCC, we show that ADAP1 overexpression promotes invasive tumor progression by facilitating cell migration and breakdown of the basement membrane. We found that ADAP1-rich, TGF-β-responding tumor cells exhibit cytop

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11

Agarwal, Pankaj, and Ram Ballabh. "Expression of type IV collagen in different histological grades of oral squamous cell carcinoma: An immunohistochemical study." Journal of Cancer Research and Therapeutics 9, no. 2 (2013): 272. http://dx.doi.org/10.4103/0973-1482.113382.

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12

Tamamura, Ryo, Hitoshi Nagatsuka, You-Jin Lee та ін. "Distribution of Collagen Type IV α1-6 Chains and MMP in Carcinogenesis in Oral Squamous Cell Carcinoma". Journal of Hard Tissue Biology 13, № 3 (2004): 117–23. http://dx.doi.org/10.2485/jhtb.13.117.

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13

Baba, Yoshifumi, Ken-ichi Iyama, Koei Ikeda та ін. "The Expression of Type IV Collagen α6 Chain Is Related to the Prognosis in Patients with Esophageal Squamous Cell Carcinoma". Annals of Surgical Oncology 15, № 2 (2007): 555–65. http://dx.doi.org/10.1245/s10434-007-9592-4.

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14

Moisejenko-Goluboviča, Jeļena, Oļegs Volkovs, Anna Ivanova, Eva Petrošina, and Valērija Groma. "What We Need to Learn When Exploring the Mixed Basal Cell Carcinoma of Head and Neck." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 75, no. 2 (2021): 75–85. http://dx.doi.org/10.2478/prolas-2021-0013.

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Abstract Coexistence of different histopathological types of basal cell carcinomas (BCC) in the same anatomical localisation is rare, and, therefore, is engaging for histopathologists and clinicians. In many cases, the determination of a neoplasm type remains difficult, since BCC may consist of more than one histopathological subtype. Mixed BCCs often present with an aggressive course and recurrence when compared to other subtypes of a tumour. Furthermore, tumours of this type are associated with time-consuming treatment and not a very satisfactory cosmetic result, thus worsening the quality o

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Lifsics, Andrejs, Valerija Groma, Maksims Cistjakovs, Sandra Skuja, Renars Deksnis, and Modra Murovska. "Identification of High-Risk Human Papillomavirus DNA, p16, and E6/E7 Oncoproteins in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas." Viruses 13, no. 6 (2021): 1008. http://dx.doi.org/10.3390/v13061008.

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Human papillomavirus (HPV) was proven to play a significant role in cancer development in the oropharynx. However, its role in the development of laryngeal (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC) remains to be clarified. High-risk HPV (HR-HPV) viral proteins E6 and E7 are considered to be pertinent to HPV-related carcinogenesis. Hence, our aim was to estimate LSCC and HPSCC for HR-HPV DNA, p16, and E6/E7 oncoprotein status by using molecular virology and immunohistochemistry methods. The prevalence of HPV16 infection was 22/41 (53.7%) and 20/31 (64.5%) for LSCC and HPSCC, acc

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Nishimura, S., H. Tsuda, K. Kajitani, et al. "ABCF2 expression may predict the prognosis of cervical cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 5045. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5045.

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5045 Background: ABCF2 is a new member of the ATP-binding cassette transporter superfamily gene. We previously reported that ABCF2 protein is new biomarker in clear cell adenocarcinoma (CC) of the ovary and its expression may predict the response to chemotherapy and survival of CC patients (Proc ASCO 2005, Clin Cancer Res 2005). In this study, we examined ABCF2 expression in cervical cancer (CACX) and evaluated the relationship between ABCF2 expression and clinical factor. Methods: Formalin-fixed surgical samples from one hundred fourty CACX were included in this study. ABCF2 expression was in

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Guarino, Marcello, Ferdinando Giordano, Francesco Pallotti, Giulio Polizzotti, Paolo Tricomi, and Enrico Cristofori. "Malignant Mixed Müllerian Tumor of the Uterus. Features Favoring its Origin from a Common Cell Clone and an Epithelial-to-Mesenchymal Transformation Mechanism of Histogenesis." Tumori Journal 84, no. 3 (1998): 391–97. http://dx.doi.org/10.1177/030089169808400316.

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Aims and background Various histogenetic mechanisms have been postulated to explain the biphasic carcinomatous-sarcomatous appearance of malignant mixed müllerian tumors (MMMTs), but the nature of these uncommon neoplasms is still unclear. Some evidence would suggest that MMMT displays similarities with sarcomatoid carcinoma, a tumor arising in extragenital sites that also features a mixed appearance. To gain further insight into the histogenesis of this tumor, we have studied by immunohistochemistry a case of uterine MMMT showing an extensive rhabdomyosarcomatous component. Methods A panel of

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18

SHIOZAKI, Takeo, and Hiroyasu NOMA. "The relationship between clinicopathologic malignancy and distribution of both cytokeratin 19 and type IV collagen in squamous cell carcinoma of the tongue." Japanese Journal of Oral & Maxillofacial Surgery 42, no. 1 (1996): 8–21. http://dx.doi.org/10.5794/jjoms.42.8.

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19

Nabukenya, Jamilah, Tessa A. Hadlock, and Wilfred Arubaku. "Head and Neck Squamous Cell Carcinoma in Western Uganda: Disease of Uncertainty and Poor Prognosis." OTO Open 2, no. 1 (2018): 2473974X1876186. http://dx.doi.org/10.1177/2473974x18761868.

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Objectives Patients with head and neck squamous cell carcinoma (HNSCC) have symptoms that masquerade as benign conditions, resulting in late presentations. The objective is to describe characteristics and stages of patients with HNSCC and document their prognosis from clinical experience in western Uganda. Study Design Cross-sectional study with clinical follow-up. Setting Mbarara Regional Referral Hospital. Subjects and Methods Fifty-one participants were recruited from February to July 2016. A questionnaire was used for patient characteristics, and staging, serologic studies, biopsy for hist

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20

Lequerica-Fernández, Paloma, Tania Rodríguez-Santamarta, Eduardo García-García та ін. "Prognostic Significance of β-Catenin in Relation to the Tumor Immune Microenvironment in Oral Cancer". Biomedicines 11, № 10 (2023): 2675. http://dx.doi.org/10.3390/biomedicines11102675.

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The aim of this study was to investigate the prognostic relevance of β-catenin expression in oral squamous cell carcinoma (OSCC) and to explore relationships with the tumor immune microenvironment. Expression of β-catenin and PD-L1, as well as lymphocyte and macrophage densities, were evaluated by immunohistochemistry in 125 OSCC patient specimens. Membranous β-catenin expression was detected in 102 (81.6%) and nuclear β-catenin in 2 (1.6%) tumors. There was an association between β-catenin expression, tumoral, and stromal CD8+ T-cell infiltration (TIL) and also the type of tumor immune microe

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21

Kherde, Pooja, and Suchitra Gosavi. "Serum levels of matrix metalloproteinase-2 in patients with oral submucous fibrosis and oral squamous cell carcinoma." International Journal of Research in Medical Sciences 8, no. 2 (2020): 636. http://dx.doi.org/10.18203/2320-6012.ijrms20200248.

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Background: Matrix metalloproteinase-2 (MMP-2), which is supposed to enable cancer cells cross the basement membrane and metastasize by selectively cleaving type IV collagen, is anticipated to be a good diagnostic and prognostic marker in oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF). Thus, the study is aimed to estimate and compare the serum MMP-2 levels in patients with OSMF and OSCC.Methods: The study was conducted on 88 subjects, divided into three groups; Group I (healthy subjects, n=28), Group II (patients with OSMF, n=30), and Group III (patients with OSCC, n=30

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MURAKAMI, MASATAKA, SABUROU MIMAKI, YUUKO SAITOU, et al. "IMMUNOHISTOLOGICAL INVESTIGATION OF TYPE IV COLLAGEN IN THE BASEMENT MEMBRANE SURROUNDING THE CANCER NEST (CANCER NEST MEMBRANE) OF HEAD AND NECK SQUAMOUS CELL CARCINOMA." Nippon Jibiinkoka Gakkai Kaiho 95, no. 11 (1992): 1773–84. http://dx.doi.org/10.3950/jibiinkoka.95.1773.

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23

Zargaran, Massoumeh, Nosratollah Eshghyar, Pejman Bakianian Vaziri та Hamed Mortazavi. "Immunohistochemical evaluation of type IV collagen and laminin-332 γ2 chain expression in well-differentiated oral squamous cell carcinoma and oral verrucous carcinoma: a new recommended cut-off". Journal of Oral Pathology & Medicine 40, № 2 (2010): 167–73. http://dx.doi.org/10.1111/j.1600-0714.2010.00983.x.

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24

Atipas, Kawita, Natthawadee Laokulrath, Janjira Petsuksiri, Narin Ratanaprasert, and Warut Pongsapich. "CD8+ T Cells and PD-L1 Expression as Prognostic Indicators in a Low Prevalence of HPV-Associated Oropharyngeal Squamous Cell Carcinoma." Current Oncology 30, no. 2 (2023): 1450–60. http://dx.doi.org/10.3390/curroncol30020111.

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Human papillomavirus (HPV) infection detected in oropharyngeal squamous cell carcinoma (OPSCC) is associated with a better survival outcome from previous literature. However, Thailand and several Asian countries have a low prevalence of HPV-associated OPSCC and, therefore, have a low positive rate of immunostaining with p16. Tumor microenvironments (TME), including tumor-infiltrating CD8+ lymphocytes (CD8+ TIL) and programmed death ligand 1 (PD-L1), are proposed as significant prognostic indicators in addition to p16. Objectives: Explore the expression p16, CD8+ TIL, and PD-L1 and its value as

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Davidson, Callam T., Eileen Miller, Morwenna Muir та ін. "11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis". PLOS ONE 18, № 3 (2023): e0255709. http://dx.doi.org/10.1371/journal.pone.0255709.

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Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angiogenesis in murine models of myocardial infarction. Angiogenesis is important in the growth of some solid tumours. This study used murine models of squamous cell carcinoma (SCC) and pancreatic ductal adenocarcinoma (PDAC) to test the hypothesis that 11β-HSD1 inhibition promotes angiogenesis and subsequent tumour growth. SCC or PDAC cells were injected i

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Saunders, Harmony Ivanna, Levi Arnold, Mary Markiewicz, and Sufi M. Thomas. "Abstract 3844: COL11A1: A driver of tumor progression and immune evasion in head and neck squamous cell carcinoma (HNSCC)." Cancer Research 82, no. 12_Supplement (2022): 3844. http://dx.doi.org/10.1158/1538-7445.am2022-3844.

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Abstract We previously reported that collagen type XI alpha 1 (COL11A1) is upregulated in head and neck squamous cell carcinoma (HNSCC) and contributes to tumor progression. Here we tested the hypothesis that COL11A1 regulates the expression of immune regulatory markers in HNSCC. Xena Browser was used to analyze 520 and 42 cancer free normal head and neck tissue samples for COL11A1 expression. The Cancer Genome Atlas (TCGA) RNASeq data from 522 HNSCC samples was downloaded and sorted by clinical parameters and RNA expression for 20,000 genes. COL11A1 expression was correlated with tumor stage

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Timoshenko, O. S., E. V. Kugaevskaya, and T. A. Gureeva. "MMP-9, MMP-2, VEGF and VEGFR-2 as Factors of Invasion and Angiogenesis in Squamous Cell Carcinoma of the Cervix." Biomedical Chemistry: Research and Methods 5, no. 4 (2022): e00187. http://dx.doi.org/10.18097/bmcrm00187.

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Tissue destruction and angiogenesis play an important role in malignant tumor progression. They are responsible for the tumor growth and progress and its ability to invade and metastasize. The key role in the destructive processes belongs to matrix metalloproteinases (MMPs), which are able to cleave almost all components of the extracellular matrix (ECM). Gelatinases MMP-2 and MMP-9 hydrolyze type IV collagen, the main component of basement membranes, thereby releasing various biologically active molecules from ECM, including vascular endothelial growth factor (VEGF). VEGF is a key regulator o

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Fardizza, Fauziah, Bambang Hermani, Nurjati Chairani Siregar, et al. "Potential Metastatic Locoregional Lymph Nodes on Squamous Cell Carcinoma Larynx: Examination of Biomarker Expression HPV, EGFR, MMP-9, TIMP-1, VEGF, E-Cadherin, and Collagen Type IV." Advanced Science Letters 24, no. 9 (2018): 6802–6. http://dx.doi.org/10.1166/asl.2018.12849.

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Sharada, P., Uma Swaminathan, B. R. Nagamalini, K. Vinod Kumar, and B. K. Ashwini. "Histoscore and Discontinuity Score − A Novel Scoring System to Evaluate Immunohistochemical Expression of COX-2 and Type IV Collagen in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma." Journal of Orofacial Sciences 13, no. 2 (2021): 96. http://dx.doi.org/10.4103/jofs.jofs_141_21.

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Preeti, Ahankare, Sridharan Gokul, and Patankar Sangeeta. "Role of Laminin in Oral Carcinogenesis." Journal of Dentists 7 (March 8, 2019): 22–26. http://dx.doi.org/10.12974/2311-8695.2019.07.4.

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Oral carcinogenesis is characterized by significant alterations occurring at the phenotypic and genotypic level resulting in uncontrolled proliferation and evasion of apoptosis. With growing tumor mass, a switch of metabolism and angiogenesis becomes important for the further development of the disease. Invasion and subsequent metastasis of the malignant cells are basic requirement for tumor promotion and progression. Cell migration plays an important in embryogenesis, inflammatory immune response, wound healing and cancer invasion. One of the important factors responsible for the tumor progre

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Kobayashi, Yutaka, Tamio Nakajima, and Takashi Saku. "Ioss of basement membranes in the invading front of O-1N, hamster squamous cell carcinoma with high potential of lymph node metastasis: An immunohistochemical study for laminin and type IV collagen." Pathology International 45, no. 5 (1995): 327–34. http://dx.doi.org/10.1111/j.1440-1827.1995.tb03465.x.

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32

Zhao, Xiao-Liang, Justine N. McCutcheon, Bhaskar Kallakury, et al. "Prognostic factors and combined histologies in 205 resected small cell lung cancer (SCLC) patients." Journal of Clinical Oncology 35, no. 15_suppl (2017): e20009-e20009. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e20009.

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e20009 Background: SCLC accounts for 15%-20% of all lung cancer, 2%-5% of them are combined SCLC. The objectives of this study were to evaluate the prognostic factors in a large series of resected SCLC patients, and to perform genetic analysis of combined forms. Methods: 205 SCLC cases were resected at Tianjin Cancer Hospital between 1/2005 and 12/2015. We analyzed: gender, age, type of resection, cigarette index (CI), tumor markers (CEA, SCC, NSE, Cyfra21-1), R resection type, number of resected lymph nodes (LNs), ratio of metastatic LNs, and pathological stage. All combined SCLC cases were i

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Zhang, Yaxiong, Ningning Zhou, Huaqiang Zhou, et al. "Intratumoral heterogeneity and tumor evolution of small cell lung cancer through multi-regional sequencing." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21103-e21103. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21103.

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e21103 Background: Small cell lung cancer (SCLC) is a type of aggressive malignancy with poor prognosis, accounting for 15% of lung cancers. Intratumoral heterogeneity (ITH) has been investigated in lung adenocarcinoma or squamous cell carcinoma, but its role in SCLC still remains unclear. Exploring ITH and tumor evolution of SCLC is essential for its treatment and prognosis. Methods: 102 multi-regional tumor tissues were collected from 34 operative SCLC patients (pts) before systemic therapy during Sep. 2009 to Sep.2018 from Sun Yat-sen University Cancer Center. All of the enrolled cases were

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Moroncini, Eleonora, Andrea Ponzetta, Magnus Nilsson, et al. "Abstract 140: Profiling ECM biomarkers PRO-C3 and PRO-C5 in plasma from patients with esophagogastric cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 140. https://doi.org/10.1158/1538-7445.am2025-140.

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Abstract Background: Esophagogastric cancer encompasses malignancies of the esophagus, esophagogastric junction, and stomach. These cancers involve distinct regions of the esophagus and gastroesophageal junction (GEJ) and exhibit unique clinicopathologic, histologic, and mutational features. The major constituents of the tumor microenvironment (TME) are besides the tumor cells themselves, cancer associated fibroblasts (CAFs), stromal cells and the extracellular matrix (ECM). CAFs synthesize excess amounts of collagens leading to a fibrotic TME with poor response to anti-cancer treatment; it wa

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35

El-Khoueiry, Anthony B., Omid Hamid, John A. Thompson, et al. "The relationship of pharmacodynamics (PD) and pharmacokinetics (PK) to clinical outcomes in a phase I study of OX40 agonistic monoclonal antibody (mAb) PF-04518600 (PF-8600)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 3027. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.3027.

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3027 Background: PF-8600 is a novel fully human IgG2 agonistic mAb against human OX40, a TNF receptor superfamily member expressed primarily on activated T cells. This ongoing phase 1 study (NCT02315066) is investigating the safety, efficacy, PK and PD of PF-8600 in patients (pts) with solid tumors. Methods: PF-8600 (0.01–10 mg/kg) was given IV every 14d. Expression of free/total OX40 receptor, proliferation marker ki67 and activation markers HLA-DR/CD38 were measured in T cell subsets in peripheral blood by flow cytometry in all pts. CD4, CD8, OX40 and FOXP3 were evaluated in paired tumor bio

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Yasuda, Takushi, Kohei Nishiki, Koji Yoshida, et al. "Cancer peptide vaccine to suppress postoperative recurrence in esophageal SCC patients with induction of antigen-specific CD8+ T cell." Journal of Clinical Oncology 35, no. 15_suppl (2017): e14635-e14635. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e14635.

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e14635 Background: This is a following report of the exploratory phase II study of adjuvant peptide vaccine for thoracic esophageal squamous cell carcinoma (TESCC) (abstract #3087 in ASCO2016), focusing on an association of immunological responses with clinical outcomes. Three HLA-A-24-restricted epitope peptides derived from cancer-testis antigens, up-regulated lung cancer 10 (URLC10), cell division cycle associated 1 (CDCA1) and KH domain-containing protein overexpressed in cancer 1 (KOC1), were used in this study. Methods: TESCC patients who underwent neoadjuvant therapy followed by curativ

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Laack, E., C. Schneider, T. Gutjahr, et al. "Association between different potential predictive markers from TRUST, a trial of erlotinib in non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 7651. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7651.

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7651 Background: Recent studies have examined potential predictive markers in NSCLC patients (pts) treated with EGFR tyrosine kinase inhibitors. However, few data are available on inter-relationships between different markers. Clinical and molecular markers were analyzed for patients from TRUST, an open label, non-randomized trial initiated to provide erlotinib access to pts with advanced NSCLC. Methods: 393 German pts (99% Caucasian) with stage IIIb/IV NSCLC were included. Markers/characteristics assessed were: EGFR (282 pts) and phosphorylated MAPK (pMAPK; 109 pts) using immunohistochemistry

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Mattar, Andre, Marcelo Antonini, Marina Diogenes, Andressa Amorim, Francisco Pimentel Cavalcante, and Luiz Henrique Gebrim. "Abstract PO2-17-10: Metaplastic breast cancer: description of 16 cases treated at a reference center and review of the literature." Cancer Research 84, no. 9_Supplement (2024): PO2–17–10—PO2–17–10. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-17-10.

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Abstract Background: Metaplastic breast carcinomas (MBC) are very rare and represent less than 1% of all invasive breast carcinomas. It is a heterogeneous neoplasm characterized by a mixture of adenocarcinoma with other histological elements such as squamous cells, spindle cells or other mesenchymal differentiation. Most MBC are hormone receptor and Her2 negative and tend to have a worse prognosis when compared to triple negative carcinomas. Clinically, they manifest as a rapidly growing palpable mass, without necessarily involving lymph nodes. According to the nomenclature of the WHO Classifi

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Lin, Iris, Oh Run Kim, Leigha Rock, et al. "Abstract 5935: Malignant risk assessment of clinical and histological subtypes of lichenoid mucositis with dysplasia." Cancer Research 82, no. 12_Supplement (2022): 5935. http://dx.doi.org/10.1158/1538-7445.am2022-5935.

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Abstract Introduction: Oral lichen planus (OLP), a common, chronic inflammatory condition, is categorized as potentially malignant by the World Health Organization. However, some hypothesize that only lichenoid lesions with dysplasia (LLD) are at risk of progression to cancer. Others have proposed subtypes of LLD, with differing malignant risks. Objectives: To determine if subtypes of LLD exist, based on clinical and histological features, and to determine the proportion of malignant progression in these subtypes. Methods: A nested case control study was conducted using tissue samples and long

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"Expression of type IV collagen and its degrading enzymes in squamous cell carcinoma of lung." Lung Cancer 12, no. 1-2 (1995): 121. http://dx.doi.org/10.1016/0169-5002(95)96297-9.

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Zhang, Jia-Yi, Wei-Wen Zhu, Meng-Yao Wang, et al. "Cancer-associated fibroblasts promote oral squamous cell carcinoma progression through LOX-mediated matrix stiffness." Journal of Translational Medicine 19, no. 1 (2021). http://dx.doi.org/10.1186/s12967-021-03181-x.

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Abstract Background Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, have prominent roles in the development of solid tumors as stromal targets. However, the underlying mechanism of CAFs’ function in oral squamous cell carcinoma (OSCC) development remains unclear. Here, we investigated the role of lysyl oxidase (LOX) expression in CAFs in tumor stromal remodeling and the mechanism of its effect on OSCC progression. Methods Multiple immunohistochemistry (IHC) staining was performed to detect the correlation of CAFs and LOX in the stroma of OSCC specim

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Tamamura, R., H. Nagatsuka, C. H. Siar, et al. "Differential expression of basement membrane collagen-IV alpha l to alpha 6 chains during oral carcinogenes." June 19, 2017. https://doi.org/10.5281/zenodo.812008.

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This study aimed to resolve if basement membrane (BM) collagen alpha chains undergo remodeling during oral. carcinogenesis. Using immunohistochemistry and transmission electron microscopy, we found that BMs in oral epithelial dysplasias (OED: mild, n=10; moderate, n=10; severe, n=10) and carcinoma in situ (CIS) (n=10) differed from normal mucosa (n=6) and oral epithelial hyperplasia (n=5) in showing: (1) excessive lamina densa-like material ultrastructurally, and (2) stronger immunoexpression for alpha 5(IV) than for alpha 1(IV), alpha 2(IV), and alpha 6(IV) chains-findings that implicate thes

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Eva, Lois, Lynn Sadler, John MD Thompson, et al. "HPV-independent and HPV-associated vulvar squamous cell carcinoma: two different cancers." International Journal of Gynecologic Cancer, August 1, 2022, ijgc—2022–003616. http://dx.doi.org/10.1136/ijgc-2022-003616.

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ObjectivesWe report the disease-specific survival of patients with human papillomavirus (HPV)-associated and HPV-independent vulvar squamous cell carcinomas and determine whether differences exist and are independent of stage and age at diagnosis.MethodsThis was a retrospective cohort study with case note and pathology slide review of 265 consecutive women with vulvar squamous cell carcinoma. These patients were treated over a 15 year period (2001–2016) at a centralized cancer center covering half the population of New Zealand. The women’s cancers were categorized dependent on their adjacent p

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Zhou, Tianyuan, Shuang Liu, Lixin Shi, and Lei Zhang. "The FUS/COL11A1/ZEB1 Axis Contributes to the Development of Oral Squamous Cell Carcinoma." Journal of Oral Pathology & Medicine, February 6, 2025. https://doi.org/10.1111/jop.13610.

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ABSTRACTObjectiveOral squamous cell carcinoma (OSCC) is a common type of head and neck cancer with high metastasis rate and poor prognosis. This study aimed to explore the role of collagen type XI alpha 1 (COL11A1) and its detailed mechanisms in OSCC progression.MethodsQuantitative reverse transcription polymerase chain reaction (RT‐qPCR) analysis was used to measure the level of COL11A1, fused in sarcoma/translocated in liposarcoma (FUS) and zinc finger E‐box binding homeobox 1 (ZEB1). The protein expression of COL11A1, E‐cadherin, N‐cadherin, FUS, and ZEB1 were detected using Western blot. 3

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Stolnicu, Simona, Douglas Allison, Aaron M. Praiss, et al. "Incidence and Clinicopathologic Characteristics of Human Papillomavirus–independent Invasive Squamous Cell Carcinomas of the Cervix." American Journal of Surgical Pathology, September 13, 2023. http://dx.doi.org/10.1097/pas.0000000000002122.

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We aimed to determine the frequency of human papillomavirus–independent (HPVI) cervical squamous cell carcinoma (SCC) and to describe clinicopathologic characteristics. Among 670 patients with surgically treated SCCs in an established multi-institutional cohort, 447 had available tissue. Tissue microarrays were constructed and studied by in situ hybridization (ISH) for high-risk and low-risk human papillomavirus (HPV) mRNA and immunohistochemistry for p16 and p53. Tumors were HPVI if negative by HPV ISH and they failed to show diffuse p16 positivity by immunohistochemistry, and human papilloma

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Chuah, K. S., C. H. Siar, K. Nakano, et al. "Wingless-type Protein-1 (Wnt-1) Expression in Primary Conventional and Unicystic Ameloblastomas and Their Recurrent Tumors." June 19, 2017. https://doi.org/10.5281/zenodo.811944.

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Wingless-type protein (Wnt) is a family of 19 secreted glycoproteins that function as signaling transducers for cell-cell interaction, cell growth and differentiation. Wnt-1, a highly transforming member, has been implicated in tumorigenesis. The aim of this study was to elucidate the role of this cell signaling molecule in the development and progression of primary ameloblastoma and their recurrent tumors. Wnt-1 expression patterns were examined immunohistochemically in 22 primary and 14 recurrent ameloblastomas. These collectively consisted of the following subtypes: conventional (CA) (n=22)

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Yaegashi, Lygia Bertalha, Camila Machado Baldavira, Tabatha Gutierrez Prieto, et al. "In Situ Overexpression of Matricellular Mechanical Proteins Demands Functional Immune Signature and Mitigates Non-Small Cell Lung Cancer Progression." Frontiers in Immunology 12 (August 16, 2021). http://dx.doi.org/10.3389/fimmu.2021.714230.

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Non-small cell lung carcinoma (NSCLC) is a complex cancer biome composed of malignant cells embedded in a sophisticated tumor microenvironment (TME) combined with different initiating cell types, including immune cells and cancer-associated fibroblasts (CAFs), and extracellular matrix (ECM) proteins. However, little is known about these tumors’ immune-matricellular relationship as functional and mechanical barriers. This study investigated 120 patients with NSCLC to describe the immune-matricellular phenotypes of their TME and their relationship with malignant cells. Immunohistochemistry (IHC)

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Tung, Hsiu‐Jung, You‐Chen Wang, Chiao‐Yun Lin, et al. "Human papillomavirus prevalence, genotype distribution, and prognostic factors of vaginal cancer." International Journal of Cancer, July 24, 2024. http://dx.doi.org/10.1002/ijc.35105.

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AbstractWe aimed to investigate human papillomavirus (HPV) prevalence and genotype distribution and prognostic factors in vaginal cancer (VC). VC patients who received treatment between 1989 and 2020 were retrospectively reviewed. L1 general polymerase chain reaction (PCR) followed by HPV Blot (King Car, I‐Lan, Taiwan) and E6 type‐specific‐PCR were performed for genotyping firstly. P16 and p53 immunohistochemistry staining was performed. Univariate and multivariate analyses identified predictors of clinical outcomes.79 VC patients were eligible for analysis. 73 patients (92.4%) were squamous c

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Duan, Xiaoling, Danjuan Ye, Jia Yuan, et al. "COL5A1 overexpression correlates with poor prognosis in human cervical cancer." International Journal of Biological Markers, July 23, 2024. http://dx.doi.org/10.1177/03936155241265976.

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Background Cervical cancer is the most prevalent malignant tumor in women. This study aims to detect collagen type V α1 chain (COL5A1) expression and its clinical relevance in the prognosis of patients with cervical cancer. Methods Cervical cancer tissues and their paired adjacent normal tissues were prepared for tissue microarray. The expression of COL5A1 protein and the scores of the expression were evaluated by immunohistochemistry (IHC) staining. The prognostic value of COL5A1 was analyzed by R software version 4.2.1 with “survival, survminer, ggplot2” packages and Gene Expression Profilin

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Qian, Xiaojun, Wei Jia, Yuntian Li, Jian Chen, Jinguo Zhang, and Yubei Sun. "COL4A1 Promotes Gastric Cancer Progression by Regulating Tumor Invasion, Tumor Microenvironment and Drug Sensitivity." Current Medicinal Chemistry 32 (April 7, 2025). https://doi.org/10.2174/0109298673351943250314074632.

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Background: Collagen type IV alpha 1 chain (COL4A1), which has been proven to be a potential biomarker in Gastric Cancer (GC), but its role in tumors and the tumor microenvironment (TME) needs further explanation. Methods: We analysed the relationship between COL4A1 and clinical characteristics based on The Cancer Genome Atlas (TCGA) database and verified by tissue microarrays as well as GC cell lines using immunohistochemistry, Q-PCR, western blot, cell proliferation assays, colony formation assays, cell invasion and migration assays. The immune infiltration and drug sensitivity information b

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