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Journal articles on the topic 'Immunologic Factors/pharmacology'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Dattner, Alan M. "Potential Immunologic and Integrative Methods to Enhance Vaccine Safety." Vaccines 10, no. 7 (2022): 1108. http://dx.doi.org/10.3390/vaccines10071108.

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Vaccine safety is measured by the disease protection it confers compared to the harm it may cause; both factors and their relative numbers have been the subject of disagreement. Cross-reactive attack of analogous self-antigens modified by dietary and microbiome factors is one of the poorly explored likely causes of harm. Screening for that and other risk factors might point out those most likely to develop severe vaccine reactions. Cooperation from those with opinions for and against vaccination in data gathering and vetting will lead to greater safety. Screening should include an integrative

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Parker, Jerry C., Karen L. Smarr, Edgar O. Angelone, et al. "Psychological factors, immunologic activation, and disease activity in rheumatoid arthritis." Arthritis Care & Research 5, no. 4 (1992): 196–201. http://dx.doi.org/10.1002/art.1790050403.

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Chen, Heng-Chang. "The Dynamic Linkage between Provirus Integration Sites and the Host Functional Genome Property Alongside HIV-1 Infections Associated with Antiretroviral Therapy." Vaccines 11, no. 2 (2023): 402. http://dx.doi.org/10.3390/vaccines11020402.

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(1) Background: The HIV-1 latent reservoir harboring replication-competent proviruses is the major barrier in the quest for an HIV-1 infection cure. HIV-1 infection at all stages of disease progression is associated with immune activation and dysfunctional production of proinflammatory soluble factors (cytokines and chemokines), and it is expected that during HIV-1 infection, different immune components and immune cells, in turn, participate in immune responses, subsequently activating downstream biological pathways. However, the functional interaction between HIV-1 integration and the activat

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Mihalyi, Attila, Kyama C. Mutinda, Peter Simsa, Sophie Debrock, Jason M. Mwenda, and Thomas M. D’Hooghe. "Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies." Therapy 2, no. 4 (2005): 623–39. http://dx.doi.org/10.2217/14750708.2.4.623.

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Triant, Virginia A., Susan Regan, Hang Lee, Paul E. Sax, James B. Meigs, and Steven K. Grinspoon. "Association of Immunologic and Virologic Factors With Myocardial Infarction Rates in a US Healthcare System." JAIDS Journal of Acquired Immune Deficiency Syndromes 55, no. 5 (2010): 615–19. http://dx.doi.org/10.1097/qai.0b013e3181f4b752.

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Bosch, Ronald J., Kara Bennett, Ann C. Collier, Robert Zackin, and Constance A. Benson. "Pretreatment Factors Associated With 3-Year (144-Week) Virologic and Immunologic Responses to Potent Antiretroviral Therapy." JAIDS Journal of Acquired Immune Deficiency Syndromes 44, no. 3 (2007): 268–77. http://dx.doi.org/10.1097/qai.0b013e31802c7e20.

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Celeketic, Dusica, Andreja Trpkovic, and Zorica Cvetkovic. "Agranulocytosis induced by metamizole and its management with granulocyte growth factor." Vojnosanitetski pregled 62, no. 1 (2005): 79–82. http://dx.doi.org/10.2298/vsp0501079c.

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Drug-induced agranulocytosis was defined as a severe selective neutropenia caused by an unexpected drug reaction. Metamizole was the most common nonopioid analgesic drug associated with agranulocytosis. It was also associated with combined blood dyscrasias and other severe immunologic disorders. The risk of agranulocytosis by metamizole seemed to be considerably higher than estimated formerly. Modern management with broad-spectrum antibiotics and haematopoietic growth factors reduced the mortality in those patients. Two cases of agranulocytosis caused by metamizole were reported.

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Swanson, George A., Gurjit Kaeley, and Stephen A. Geraci. "Diffuse Pulmonary Hemorrhage after Streptokinase Administration for Acute Myocardial Infarction." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 17, no. 2 (1997): 390–94. http://dx.doi.org/10.1002/j.1875-9114.1997.tb03727.x.

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Fibrinolytic drug therapy has markedly reduced morbidity and mortality from acute myocardial infarction. As with any other drug therapy, however, benefits are maximal when patients at higher risk for complications can be identified and treatment decisions modified to reduce the chance of adverse events. Streptokinase, a commonly used and inexpensive thrombolytic, is known to cause both bleeding and immunologic complications, and coexistent conditions predisposing to either are considered relative or absolute contraindications to its use. We report an unusual case of immune‐mediated diffuse pul

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Hutter, Stefan, Julia Knabl, Ulrich Andergassen, and Udo Jeschke. "The Role of PPARs in Placental Immunology: A Systematic Review of the Literature." PPAR Research 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/970276.

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Pregnancy is a state of immunotolerance, and pregnancy outcome is strongly linked to the correct activation and balancing of the maternal immune system. Besides abortion as possible result of improper early pregnancy development, other pregnancy associated conditions like preeclampsia (PE), intrauterine growth retardation (IUGR), preterm labour, or gestational diabetes mellitus (GDM) are linked to immunologic overactivation and dysregulation. Both the innate and the adaptive immune system, and therefore B and T lymphocytes, natural killer cells (NK), macrophages and dendritic cells (DCs) are a

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Gandhi, Rajesh T., John Spritzler, Ellen Chan, et al. "Effect of Baseline- and Treatment-Related Factors on Immunologic Recovery After Initiation of Antiretroviral Therapy in HIV-1-Positive Subjects." JAIDS Journal of Acquired Immune Deficiency Syndromes 42, no. 4 (2006): 426–34. http://dx.doi.org/10.1097/01.qai.0000226789.51992.3f.

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Wang, Ena, Alessandra Cesano, Lisa H. Butterfield, and Francesco Marincola. "Improving the therapeutic index in adoptive cell therapy: key factors that impact efficacy." Journal for ImmunoTherapy of Cancer 8, no. 2 (2020): e001619. http://dx.doi.org/10.1136/jitc-2020-001619.

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The therapeutic index (TI) is a quantitative assessment of a drug safety proportional to its effectiveness. The estimation is intuitive when the engagement of the product with its target is dependent on stable chemistry and predictable pharmacokinetics as is the case for small molecules or antibodies. But for therapeutics with complex biodistribution and context-dependent potency such as adoptive cell therapy (ACT) products, TI estimations need to consider a broader array of factors. These include product-dependent variability such as functional fitness, unpredictable pharmacokinetics due to n

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Sherman, Amy C., Lilin Lai, Mary Bower, et al. "The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination." Vaccines 8, no. 4 (2020): 663. http://dx.doi.org/10.3390/vaccines8040663.

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(1) Background: The influenza virus continues to cause significant annual morbidity and mortality. The overall efficacy of seasonal influenza vaccination is suboptimal, which is partly due to host immune factors. The effects of imprinting and repeated seasonal influenza vaccination were investigated to assess for immune factors and mechanisms that impact influenza vaccine responses. (2) Methods: Twenty participants were enrolled into a prospective pilot study based on birth cohort and seasonal influenza immunization history. Immunologic parameters were assessed over a six-month period after th

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Estes, Kristina E., Kristin H. Busse, and Scott R. Penzak. "Pharmacogenetic Considerations in the Management of HIV Infection." Journal of Pharmacy Practice 20, no. 3 (2007): 234–45. http://dx.doi.org/10.1177/0897190007304819.

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Potent combination antiretroviral drug therapy has now been available to HIV-infected patients for more than a decade, resulting in a significant decline in disease-related morbidity and mortality. Nonetheless, a number of HIV-infected individuals fail to experience the full benefit of their antiretroviral medications; some lack a robust virologic response, while others experience treatment-limiting toxicities. A number of factors may contribute to variable drug response in patients with HIV infection. Virologic, immunologic, pharmacologic, and pharmacokinetic differences between HIV-infected

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Emmanouilidou-Fotoulaki, Elpida, Vasiliki Karava, John Dotis, Antonia Kondou, and Nikoleta Printza. "Immunologic Response to SARS-CoV-2 Vaccination in Pediatric Kidney Transplant Recipients: A Systematic Review and Meta-Analysis." Vaccines 11, no. 6 (2023): 1080. http://dx.doi.org/10.3390/vaccines11061080.

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The pediatric population is at a lower risk of severe SARS-CoV-2 infection compared to adults. Nevertheless, immunosuppression in pediatric and adolescent kidney transplant recipients (KTRs) increases their hazard compared to the general population. This systematic review evaluates the efficacy of SARS-CoV-2 vaccines and determines the risk factors of no seroconversion in this population. PubMed-MEDLINE databases were searched for cohort studies. A meta-analysis was performed using fixed and random effect models. In total, seven studies including 254 patients were further analyzed. The random

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James, Nicole, Melih Ozsoy, Payton De La Cruz, Morgan Woodman, and Jennifer Ribeiro. "729 Immunologic tumor cell intrinsic effects of standard of care therapies for ovarian cancer." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A758. http://dx.doi.org/10.1136/jitc-2021-sitc2021.729.

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BackgroundOutcomes for high grade serous ovarian cancer (HGSOC) patients have remained dismal due to the inevitable development of chemotherapy resistance with recurrent disease.1 In order to better tailor treatment approaches and uncover opportunities for novel treatments, we need to better understand factors contributing to chemotherapy resistance. Recent studies have shown that immune-related gene expression profiles may serve as prognostic indicators of response to chemotherapy and clinical outcomes in solid tumors, including ovarian cancer.2–7 Moreover, immunologic factors have been shown

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Chastain, Daniel B., Andrés F. Henao-Martínez, Austin C. Dykes, et al. "Missed opportunities to identify cryptococcosis in COVID-19 patients: a case report and literature review." Therapeutic Advances in Infectious Disease 9 (January 2022): 204993612110663. http://dx.doi.org/10.1177/20499361211066363.

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SARS-CoV-2 may activate both innate and adaptive immune responses ultimately leading to a dysregulated immune response prompting the use of immunomodulatory therapy. Although viral pneumonia increases the risk of invasive fungal infections, it remains unclear whether SARS-CoV-2 infection, immunomodulatory therapy, or a combination of both are responsible for the increased recognition of opportunistic infections in COVID-19 patients. Cases of cryptococcosis have previously been reported following treatment with corticosteroids, interleukin (IL)-6 inhibitors, and Janus kinase (JAK) inhibitors, f

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Özenírler, Seren, Candan Tuncer, Ülver Boztepe, et al. "Propylthiouracil-Lnduced Hepatic Damage." Annals of Pharmacotherapy 30, no. 9 (1996): 960–63. http://dx.doi.org/10.1177/106002809603000909.

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OBJECTIVE: To report a case of propylthiouracil-induced hepatic damage. CASE SUMMARY: A 64-year-old white woman with hyperthyroidism received propylthiouracil 250 mg/d for 1 year. She developed hepatitis after 1 year of therapy. Alcohol and drug abuse were ruled out and all serologic tests for hepatitis A, B, and C were negative. Cytomegalovirus and Epstein-Barr virus infection were also ruled out. Antinuclear antibody, antimitochondrial antibody, and antismooth muscle antibody were negative. The clinical picture was similar to that of viral hepatitis characterized by nausea, vomiting, and jau

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Taghavi, Hossein, Jafar Soleimani Rad, Ahmad Mehdipour, et al. "Effect of Mineral Pitch on the Proliferation of Human Adipose Derived Stem Cells on Acellular Scaffold." Advanced Pharmaceutical Bulletin 10, no. 4 (2020): 623–29. http://dx.doi.org/10.34172/apb.2020.075.

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Purpose : Acellular scaffold extracted from extracellular matrix (ECM) have been used for constructive and regenerative medicine. Adipose derived stem cells (ADSCs) can enhance the vascularization capacity of scaffolds. High mobility group box 1 (HMGB1) and stromal derived factor1 (SDF1) are considered as two important factors in vascularization and immunologic system. In this study, the effect of mineral pitch on the proliferation of human ADSCs was evaluated. In addition to HMGB1 and SDF1, factors expression in acellular scaffold was also assessed. Methods: To determine acellular scaffold mo

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Sanabria-Cabrera, Judith, Inmaculada Medina-Cáliz, Simona Stankevičiūtė, et al. "Drug-Induced liver Injury Associated with Severe Cutaneous Hypersensitivity Reactions: A Complex Entity in Need of a Multidisciplinary Approach." Current Pharmaceutical Design 25, no. 36 (2019): 3855–71. http://dx.doi.org/10.2174/1381612825666191107161912.

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Idiosyncratic drug-induced liver injury (DILI) occasionally occurs in the setting of severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). This strengthens the proposed immunologic mechanism associated with this adverse reaction. DRESS exhibits the most common association with DILI. SCARs have a wide spectrum of heterogeneous clinical presentations and severity, and genetic predisposition has been identified. In the context of SCARs, DILI present a different clini

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Sintusek, Palittiya, Supranee Buranapraditkun, Piyaporn Wanawongsawad, et al. "Safety and Immunogenicity of Standard and Double Doses of Hepatitis B Vaccine in Children after Liver Transplantation: An Open-Label, Randomised Controlled Trial." Vaccines 10, no. 1 (2022): 92. http://dx.doi.org/10.3390/vaccines10010092.

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A high prevalence of hepatitis B (HepB) antibody loss after liver transplantation (LT) and de novo HepB infection (DNH) was documented, hence revaccination to prevent DNH is crucial. This study aimed to compare the safety and immunogenicity of two HepB vaccine regimens in liver-transplanted children. Liver-transplanted children who were previously immunised but showed HepB surface antibodies (anti-HBs) ≤ 100 mIU/mL were randomised to receive a standard three-dose (SD) and double three-dose (DD) vaccine intramuscularly in months 0–1–6. Anti-HBs and T-cell-specific response to the HepB antigen w

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Dambadarjaa, Davaalkham, Otgonbayar Radnaa, Ser-Od Khuyag, et al. "Hepatitis B, C, and D Virus Infection among Population Aged 10–64 Years in Mongolia: Baseline Survey Data of a Nationwide Cancer Cohort Study." Vaccines 10, no. 11 (2022): 1928. http://dx.doi.org/10.3390/vaccines10111928.

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Hepatitis B, C, and D virus infections are a major public health problem, and Mongolia has one of the highest prevalences of dual and triple infections in the world. We aimed to determine the seroprevalence of hepatitis infection and dual or triple hepatitis infections among 10–64-year-olds. A questionnaire was used to identify risk factors for hepatitis infection, and seromarkers were measured by the fully automated immunologic analyzer HISCL-5000. Among a total of 10,040 participants, 8.1% of the population aged 10–64 was infected with HBV, 9.4% with HCV, and 0.4% with HBV and HCV, and the p

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Limmer, Andreas, Andrea Engler, Simone Kattner, et al. "Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease State." Vaccines 11, no. 2 (2023): 435. http://dx.doi.org/10.3390/vaccines11020435.

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Background: It is widely accepted that SARS-CoV-2 causes a dysregulation of immune and coagulation processes. In severely affected patients, viral sepsis may result in life endangering multiple organ dysfunction. Furthermore, most therapies for COVID-19 patients target either the immune system or coagulation processes. As the exact mechanism causing SARS-CoV-2-induced morbidity and mortality was unknown, we started an in-depth analysis of immunologic and coagulation processes. Methods: 127 COVID-19 patients were treated at the University Hospital Essen, Germany, between May 2020 and February 2

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Vianzon, Vianca, Ishita Garg, Kara Greenfield, Kathryn Knoop, and Laura Rogers. "511 Tumor immune microenvironment in adult mice asynchronously cross-fostered as pups." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A547. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0511.

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BackgroundImmune responses to cancer are highly variable and influenced by genetic and environmental factors.1 Syngeneic tumor models in mice with intact immune systems are required to study anti-tumor immune responses but are unable to adequately model varied immune responses. Classically, different mouse strain backgrounds have been used to compare different immune responses to cancer immunotherapy, but this approach is limited by the inability to administer identical tumor cell lines, keeping constant the tumor while experimentally varying the immune response. Proper establishment of the im

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Galand, Claire, Vignesh Venkatraman, Marilyn Marques та ін. "377 AGEN2373 is a CD137 agonist antibody designed to leverage optimal CD137 and FcγR co-targeting to promote antitumor immunologic effects". Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A402. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0377.

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BackgroundCD137 (4-1BB) represents a costimulatory pathway that promotes T, NK, and dendritic cell effector functions favorable for antitumor immunity. The extracellular domain of CD137, comprised of four cysteine-rich domains (CRD-I, CRD-II, CRD-III, CRD-IV), trimerizes upon binding to CD137 ligand (CD137L) to induce cell stimulatory transcriptional and epigenetic changes.1 2 The investigation of CD137-targeting agonist antibody, urelumab (CRD-I-binding, IgG4), in human subjects showed immunologic and pharmacodynamic effects, but poor efficacy due to dose-limiting liver toxicity.3 Preclinical

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James, Nicole, Katrin Eurich, Erin Lips, Payton De La Cruz, Morgan Woodman, and Jennifer Ribeiro. "31 Serum LAG-3 is associated with improved patient prognosis in high grade serous ovarian cancer." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A36. http://dx.doi.org/10.1136/jitc-2021-sitc2021.031.

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BackgroundHigh grade serous ovarian cancer (HGSOC) is a lethal gynecologic malignancy with a five-year survival rate of only 39 percent.1 Despite the fact that ovarian tumors are considered immunologic, HGSOC patients respond poorly to PD-1 based immunotherapy. Hence, the need to identify novel prognostic and therapeutic immunologic factors is crucial. Our previous investigation uncovered intratumoral levels of immune co-inhibitory receptor LAG-3 as a marker of improved HGSOC patient survival. For this current study we sought to evaluate the prognostic utility of serum-based LAG-3, as well as

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Hess, David A., and Michael J. Rieder. "The Role of Reactive Drug Metabolites in Immune-Mediated Adverse Drug Reactions." Annals of Pharmacotherapy 31, no. 11 (1997): 1378–87. http://dx.doi.org/10.1177/106002809703101116.

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OBJECTIVE: To highlight recent advances in the understanding of adverse drug reactions (ADRs), with a focus on models outlining interactions between drug metabolism, disease processes, and immunity. Specific mechanisms that identify the metabolic pathways responsible for drug bioactivation to reactive drug metabolites (RDMs) involved in the initiation and propagation of specific immune-mediated hypersensitivity reactions are discussed. Drug classes well known to be associated with immune-mediated ADRs are reviewed and the clinical implications of current research are discussed. DATA SOURCES: O

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Morris, Ashley K., and Amy Wells Valley. "Overview of the Management of AIDS-Related Kaposi's Sarcoma." Annals of Pharmacotherapy 30, no. 10 (1996): 1150–63. http://dx.doi.org/10.1177/106002809603001015.

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OBJECTIVE: To review the epidemiology, pathogenesis, clinical presentation, diagnosis, and staging of Kaposi's sarcoma (KS), as well as the current role of local and systemic therapies in the management of AIDS-related KS (AIDS–KS). DATA SOURCES AND STUDY SELECTION: MEDLINE and CANCERLIT searches of the English-language medical literature were conducted. Emphasis was placed on studies published since the onset of the AIDS epidemic in the early 1980s. A manual review of selected bibliographies was also completed. DATA SYNTHESIS: AIDS–KS is a disease with a heterogeneous presentation that affect

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Brzozowska, Ewa, Tomasz Lipiński, Agnieszka Korzeniowska-Kowal, Karolina Filik, Andrzej Górski, and Andrzej Gamian. "Detection and Level Evaluation of Antibodies Specific to Environmental Bacteriophage I11mO19 and Related Coliphages in Non-Immunized Human Sera." Antibiotics 12, no. 3 (2023): 586. http://dx.doi.org/10.3390/antibiotics12030586.

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Bacteriophages (phages) are viruses infecting bacteria. They are widely present in the environment, food, and normal microflora. The human microbiome is a mutually interdependent network of bacteria, bacteriophages, and human cells. The stability of these tri-kingdom interactions may be essential for maintaining immunologic and metabolic health. Phages, as with each other’s antigens, may evoke an immune response during a human’s lifetime and induce specific antibody generation. In this manuscript, we labeled these antibodies as naturally generated. Naturally generated antibodies may be one of

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Novosadyuk, Tatyana Vladimirovna. "The phenomenon of interdependent states of animals and humans: tactics and treatment strategy using ultra-high dilutions of substances, 20-year research." International Journal of High Dilution Research - ISSN 1982-6206 17, no. 1 (2021): 11–12. http://dx.doi.org/10.51910/ijhdr.v17i1.888.

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Before the start of our research, there already was empirically developed experience on the appearance of similar conditions in animals and humans in close contact. However, there was no scientific explanation for this phenomenon, or scientifically grounded recommendations for its application in medical practice. Since 1995 we have been systematically studied cases of humans and animals in close contact exhibited a same pathological condition. The aim of the present study was to establish the features of these interdependent states and the factors that influence them. The experimental an

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Chehrazi-Raffle, Alexander, Luis Meza, Marice Alcantara, et al. "Circulating cytokines associated with clinical response to systemic therapy in metastatic renal cell carcinoma." Journal for ImmunoTherapy of Cancer 9, no. 3 (2021): e002009. http://dx.doi.org/10.1136/jitc-2020-002009.

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BackgroundCirculating cytokines and angiogenic factors have been associated with clinical outcomes in patients with metastatic renal cell carcinoma (RCC) receiving systemic therapy. However, none have yet examined cytokine concentrations in parallel cohorts receiving either immunotherapy or targeted therapy.MethodsIn this prospective correlative study, we enrolled 56 patients who were planned for treatment with either a vascular endothelial growth factor-tyrosine kinase inhibitor (VEGF-TKI) or immune checkpoint inhibitor (ICI). Eligibility requirements permitted any RCC histologic subtype, Int

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Ceballos, Maria Elena, Patricio Ross, Martin Lasso, et al. "Clinical characteristics and outcomes of people living with HIV hospitalized with COVID-19: a nationwide experience." International Journal of STD & AIDS 32, no. 5 (2021): 435–43. http://dx.doi.org/10.1177/0956462420973106.

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In this prospective, multicentric, observational study, we describe the clinical characteristics and outcomes of people living with HIV (PLHIV) requiring hospitalization due to COVID-19 in Chile and compare them with Chilean general population admitted with SARS-CoV-2. Consecutive PLHIV admitted with COVID-19 in 23 hospitals, between 16 April and 23 June 2020, were included. Data of a temporally matched-hospitalized general population were used to compare demography, comorbidities, COVID-19 symptoms, and major outcomes. In total, 36 PLHIV subjects were enrolled; 92% were male and mean age was

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Keown, P. A., D. Lirenman, J. Carter, et al. "Use of cyclosporine in pediatric transplantation: Immunology, pharmacology and therapeutic implications." Clinical Transplantation 5, no. 2pt2 (1991): 181–85. http://dx.doi.org/10.1111/j.1399-0012.1991.tb00081.x.

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During the past decade cyclosporine has played a vital role in pediatric organ transplantation. It exerts a modulatory effect at many sites in the immune response. In young children cyclosporine clearance is significantly increased. Moreover, children are frequently on other drugs which may affect cyclosporine metabolism. These factors have to be taken into account for planning dosing regimens in children. Therapeutic monitoring has added to the efficacy and safety of cyclosporine use, particularly in those situations such as pediatric transplantation where metabolism is appreciably altered.

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Dai, Wei-Wei, Li-Bo Wang, Guo-Qin Jin, et al. "Beta-Ecdysone Protects Mouse Osteoblasts from Glucocorticoid-Induced Apoptosis In Vitro." Planta Medica 83, no. 11 (2017): 888–94. http://dx.doi.org/10.1055/s-0043-107808.

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AbstractGlucocorticoid-induced osteoporosis is a common form of secondary osteoporosis. Glucocorticoids affect both bone formation and resorption, and prolonged glucocorticoid exposure can suppress osteoblast activities. beta-Ecdysone, found in many plants, is involved in protein synthesis, carbohydrate and lipid metabolism, and immunologic modulation. Here, we evaluated the effects of beta-ecdysone on osteoblast viability by assessing apoptosis following treatment with excess glucocorticoids. Mouse bone marrow stromal cells were induced to differentiate and grow into osteoblasts, and then tre

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Drusano, G. L., J. A. Bilello, D. S. Stein, et al. "Factors Influencing the Emergence of Resistance to Indinavir: Role of Virologic, Immunologic, and Pharmacologic Variables." Journal of Infectious Diseases 178, no. 2 (1998): 360–67. http://dx.doi.org/10.1086/515631.

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Jonsson, H., and S. L. Peng. "Forkhead transcription factors in immunology." CMLS Cellular and Molecular Life Sciences 62, no. 4 (2005): 397–409. http://dx.doi.org/10.1007/s00018-004-4365-8.

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Stefanus, Soewito Sutantoc, and Gusti Putu Raka Ariani Ni. "Atopic Dermatitis: A Review on Diagnosis and Management." International Journal of Research and Review 7, no. 6 (2020): 113–19. https://doi.org/10.5281/zenodo.3952134.

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Atopic Dermatitis (AD), also known as eczema, is a chronic, relapsing, and itchy inflammatory skin condition. The pathogenesis of AD including genetic, environmental, and immunologic factors. The primary biologic changes in AD are decreased skin barrier function, Filaggrin gene impairment, and Calcineurin-mediated Th2 cell activation. History taking and clinical manifestations play an essential role in ruling out common differential diagnoses because there is no specific diagnostic tool for AD. The management of AD varies in children and adults depend on the severity of cases. Successful treat

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POIRIER, M. F. "NON SPECIFIC FACTORS OF VARIATION IN RESEARCH ON PSYCHO-IMMUNOLOGY." Clinical Neuropharmacology 15 (1992): 127B. http://dx.doi.org/10.1097/00002826-199202001-00245.

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Tsukioki, Takahiro, Tadahiko Shien, Takehiro Tanaka, et al. "Influences of preoperative metformin on immunological factors in early breast cancer." Cancer Chemotherapy and Pharmacology 86, no. 1 (2020): 55–63. http://dx.doi.org/10.1007/s00280-020-04092-2.

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Gelpi, Rosana, Angela Casas, Omar Taco, et al. "Kidney Transplant: More than Immunological Problems." Journal of Clinical Medicine 14, no. 6 (2025): 2101. https://doi.org/10.3390/jcm14062101.

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Kidney transplantation (KT) represents a pivotal intervention for patients with chronic kidney disease (CKD), significantly improving survival and quality of life. However, KT recipients face an array of non-immunological complications, collectively amplifying cardiovascular (CV) and metabolic risks. This review explores the intersection of cardio-metabolic syndrome and KT, emphasizing the recently introduced cardiovascular–kidney–metabolic (CKM) syndrome. CKM syndrome integrates metabolic risk factors, CKD, and CV disease, with KT recipients uniquely predisposed due to immunosuppressive thera

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Napiórkowska-Baran, Katarzyna, Paweł Treichel, Adam Wawrzeńczyk, et al. "Non-Celiac Villous Atrophy—A Problem Still Underestimated." Life 15, no. 7 (2025): 1098. https://doi.org/10.3390/life15071098.

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Non-celiac villous atrophy (NCVA) is a multifaceted and under-recognized clinical entity with an etiology beyond celiac disease. This review critically examines the diverse pathophysiological mechanisms underlying NCVA, including autoimmune enteropathies, immune deficiency-related disorders, infectious processes, drug-induced trauma, and metabolic or environmental influences. A comprehensive synthesis of peer-reviewed literature, clinical studies, and case reports was conducted, adopting a multidisciplinary perspective that integrates immunologic, infectious, metabolic, and pharmacologic insig

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Saxena, Hari Om, Asima Das, and Samiksha Parihar. "Dillenia pentagyna Roxb.: A Review on Phytochemistry and Pharmacology." Journal of Phytopharmacology 11, no. 4 (2022): 295–99. http://dx.doi.org/10.31254/phyto.2022.11413.

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Dillenia pentagyna often known as ‘Karmal’ is a member of Dilleniaceae. Different parts of the plant have been used by tribal communities to treat a broad spectrum of ailments. The plant reports the presence of some vital therapeutic compounds such as botulin, botulinic acid, botulinic acid, morolic acid, lupeol, diploic acid, etc. Some of the major pharmaceutical properties of the plant are anticancerous, anti-fungal, anti-bacterial, and anti-diabetic. This plant has been recently classified as a critically endangered species in Madhya Pradesh state. Low germination rates are one of the major

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vinatha, Naini, and Mamidala Estari. "An Ethnobotanical Study of Plants used for the Treatment of Diabetes in the Warangal District, Andhra Pradesh, India." Biolife 1, no. 1 (2022): 24–28. https://doi.org/10.5281/zenodo.7181042.

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<strong>ABSTRACT</strong> Herbal  medicine  is  gaining  popularity  both  in  developing  and  developed  countries  because  of  their  natural  origin.  The herbal drugs with antidiabetic activity are yet to be commercially formulated as modern medicines, even though they have been acclaimed for their therapeutic properties in the traditional systems of medicine. Ethnobotanical documentation is one way of capturing this body of knowledge. An Ethnobotanical survey was conducted on the medicinal plants frequently

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Manzano, María Dolores, Javier Cereza, Jesús García, et al. "Factors Involved in the Immunological Protection against Rabies Virus in Dogs in Spain." Vaccines 12, no. 3 (2024): 293. http://dx.doi.org/10.3390/vaccines12030293.

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Rabies, a viral disease spread by infected animal bites that causes encephalitis in humans and other mammals, is a neglected infectious disease present on all continents except Antarctica. Spain has been free of terrestrial rabies since 1978. However, due to its geographical situation, it represents a bridge for imported cases from an endemic continent such as Africa to Europe. Rabies vaccination in dogs is an essential preventive tool against this zoonosis. The aim of this study was to determine the state of the immune response against rabies virus in dogs in Spain and to demonstrate whether

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Kuter, David J. "New thrombopoietic growth factors." Blood 109, no. 11 (2007): 4607–16. http://dx.doi.org/10.1182/blood-2006-10-019315.

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AbstractAlthough development of first-generation thrombopoietic growth factors (recombinant human thrombopoietin [TPO] and pegylated recombinant human megakaryocyte growth and development factor [PEG-rHuMGDF]) was stopped due to development of antibodies to PEG-rHuMGDF, nonimmunogenic second-generation thrombopoietic growth factors with unique pharmacologic properties have been developed. TPO peptide mimetics contain TPO receptor-activating peptides inserted into complementarity-determining regions of Fab (Fab 59), attached to the IgG Fc region (AMG 531), or pegylated (Peg-TPOmp). Orally avail

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Nayak, Satyaprakash, Dooyoung Lee, Steven Arkin, et al. "A Quantitative Systems Pharmacology Model for the Coagulation Network Describes Biomarker Changes Observed in a Clinical Study with FXa Variant and Predicts Age-Associated Biomarker Variations." Blood 126, no. 23 (2015): 3502. http://dx.doi.org/10.1182/blood.v126.23.3502.3502.

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Abstract It is known that the coagulation factor levels change with age. In this work, we have applied a quantitative systems pharmacology (QSP) model of the coagulation network to predict whether age related changes in coagulation factor levels will impact dose response for PF-05320907 on various pharmacodynamic endpoints. PF-05230907 (PF-907) is a variant of FXa, in which the conformational transition from zymogen to active protease is impaired. Binding to activated factor V facilitates its transition to the active conformation, rescues procoagulant activity and is hypothesized to localize P

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Warren, Beth Boulden, Daksha Ranade, Beth Wathen, et al. "Daily Evaluation of Venous Thromboembolism (VTE) Risk Factors and Prophylaxis Safely Decreased Incidence of VTE in a Pediatric ICU." Blood 124, no. 21 (2014): 4860. http://dx.doi.org/10.1182/blood.v124.21.4860.4860.

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Abstract Background: Venous thromboembolism (VTE), consisting of deep vein thrombosis and pulmonary embolism, is associated with significant morbidity and mortality. The incidence of VTE, particularly VTE acquired by hospitalized children, has increased dramatically over the last 15 years but may be preventable in some cases. Reducing the incidence of hospital-acquired VTE may not only improve patient care but also decrease healthcare costs associated with diagnosis and treatment. Methods: In conjunction with the Children’s Hospitals’ Solutions for Patient Safety, we have developed a risk-base

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Sarfaraz, Sabahat, and Sabiha Anis. "Multiple Autoimmune Syndrome: An Unusual Combination of Autoimmune Disorders." Reviews on Recent Clinical Trials 15, no. 3 (2020): 240–43. http://dx.doi.org/10.2174/1574887115666200621184110.

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Background: Autoimmune diseases are multifactorial with environmental and heritable factors. Autoimmunity reflects an altered immune status, therefore the presence of more than one disorder is not uncommon. The coexistence of three or more autoimmune diseases in a patient constitutes multiple autoimmune syndrome (MAS). This is an interesting case of a middle-aged female who had celiac disease, primary biliary cholangitis, autoimmune hepatitis and evolving CREST (Calcinosis, Rhaynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly and Telangiectasia) syndrome. Case Report: Fifty years old f

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Kumar, Pravin, Dinesh Kumar Sharma, and Mahendra Singh Ashawat. "Pathophysiology and Management of Atopic Dermatitis: A Laconic Review." Current Drug Therapy 15, no. 4 (2020): 321–36. http://dx.doi.org/10.2174/1574885514666190828152316.

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Conclusion: : Atopic Dermatitis (AD) is long-lasting degenerating skin disease with a characteristic phenotype and stereotypically spread skin lesions. The AD results due to a complex interface among genetic factors, host’s surroundings, pharmacological anomalies and immunological factors. In previous decades, researchers had shown marked interest due to increased prevalence in developed countries. In this review, basics along with the advances in pathogenesis and management of AD have been discussed. The immunological factors i.e. Innate Lymphoid Cells, IL-22 and Toll-like receptors have an i

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Wang, Xuening, Shengxiang Xiao, and Yumin Xia. "Tumor Necrosis Factor Receptor Mediates Fibroblast Growth Factor-Inducible 14 Signaling." Cellular Physiology and Biochemistry 43, no. 2 (2017): 579–88. http://dx.doi.org/10.1159/000480530.

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Tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) engages its sole receptor, fibroblast growth factor–inducible 14 (Fn14), which participates in various inflammatory and immunologic processes. TWEAK/Fn14 interaction induces different cell fates depending on the local microenvironment, which correlates with certain expression profiles of TNF receptors (TNFR). The predominant expression of TNFR1 or TNFR2 facilitates cell death or proliferation, respectively, on TWEAK/Fn14 activation. TNFR-associated factors (TRAF) interact with Fn14, cellular inhibitor of apoptosis protein (c

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Giacinto, Omar, Umberto Satriano, Antonio Nenna, et al. "Inflammatory Response and Endothelial Dysfunction Following Cardiopulmonary Bypass: Pathophysiology and Pharmacological Targets." Recent Patents on Inflammation & Allergy Drug Discovery 13, no. 2 (2019): 158–73. http://dx.doi.org/10.2174/1872213x13666190724112644.

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Background: Endothelial injury occurring during cardiopulmonary bypass is a major contributing factor in the development of organ dysfunction, which leads to many of the postoperative complications occurring during cardiac surgery. Objective: This narrative review aims to summarize the main mechanisms of cardiopulmonary bypass - related disease, evaluating the unfavorable events leading to tissue injury, with a description of current pharmacologic and non-pharmacologic mechanisms to reduce CPB-related injury. Methods: A Medline/Pubmed/Scopus search was conducted using clinical queries with the

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