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Relevant bibliographies by topics / Immunologic techniques / Dissertations / Theses

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Dissertations / Theses on the topic 'Immunologic techniques'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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1

Happonen, Risto-Pekka. "Immunocytochemical diagnosis of cervicofacial actinomycosis with special emphasis on periapical inflammatory lesions /." Turku : Institute of Dentistry, University of Turku, 1986. http://catalog.hathitrust.org/api/volumes/oclc/14126035.html.

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2

Dahl, Helena. "Epidemiology and pathogenesis of HHV-6 /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-100-4/.

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3

Guven, Hayrettin. "The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-564-X/.

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4

Goddard, Elizabeth Anne. "IgG subclasses, specific antibodies and immunoglobulin allotypes in children with invasive Haemophilus influenzae type B and Staphylococcus aureus infections." Doctoral thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/27003.

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OBJECTIVE: The principal objective of this study was to measure various aspects of immunity in children with invasive infections due to Haemophilus influenzae type b and Staphylococcus aureus. These serious infections are a significant cause of childhood morbidity and mortality in all populations and affect healthy as well as compromised children. Evidence suggests that imbalances or deficiencies in certain aspects of immunity such as IgG subclasses, the capacity to make specific subclass antibodies, antibody affinities, complement isotypes, immunoglobulin allotypes or mannose binding protein

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5

Makarananda, Kittima. "Immunological detection of human exposure to aflatoxins." Thesis, University of Surrey, 1989. http://epubs.surrey.ac.uk/847764/.

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There is considerable evidence indicating an association between aflatoxin ingestion and liver cancer in humans. The development of methods that would permit the monitoring of aflatoxin exposure in individuals would provide useful information in assessing human risk from this toxin. In this study, an ELISA technique, using a polyclonal antibody raised against aflatoxin B1 in the rabbit, was developed for monitoring the levels of aflatoxin excreted in human urine samples. Urine could not be used directly in the assay because high blanks were observed from the presence of some aflatoxin-like sub

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6

Woodward, Robert. "Molecular and immunological characterization of cytoskeletal proteins in Trypanosoma brucei." Thesis, University of Kent, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292369.

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7

Mann, Aisling M. "Immunological and biochemical techniques in the analysis of tear proteins." Thesis, Aston University, 1998. http://publications.aston.ac.uk/9598/.

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This study is concerned with the analysis of tear proteins, paying particular attention to the state of the tears (e.g. non-stimulated, reflex, closed), created during sampling, and to assess their interactions with hydrogel contact lenses. The work has involved the use of a variety of biochemical and immunological analytical techniques for the measurement of proteins, (a), in tears, (b), on the contact lens, and (c), in the eluate of extracted lenses. Although a diverse range of tear components may contribute to contact lens spoilation, proteins were of particular interest in this study becau

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8

梁子明 and Tze-ming Leung. "Immunological studies of a phosphorylcholine-specific antibody using gene transfer techniques." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31233740.

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9

Leung, Tze-ming. "Immunological studies of a phosphorylcholine-specific antibody using gene transfer techniques /." [Hong Kong] : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13762680.

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10

Montgelard, Claudine. "Systématique moléculaire (immunologie) de quelques muridae actuels et fossiles." Montpellier 2, 1991. http://www.theses.fr/1991MON20252.

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La systematique de quelques muridae a ete etablie en comparant une proteine, l'albumine, par des methodes immunologiques. La premiere partie se rapporte a la position systematique du genre acomys, vis-a-vis de quelques representants des murinae et des sous-familles proches. Les resultats obtenus montrent en particulier la proximite d'acomys et d'uranomys. Dans l'hypothese de constance des taux d'evolution, acomys et uranomys se placent entre cricetomys qui constitue le genre le plus eloigne et un groupe compose de mus, rattus et gerbillus, ce dernier genre etant tres proche des murinae. Dans l

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11

Gutschmidt, Andrea. "Evaluation of anti-tuberculosis responses in humans using different complementary immunological techniques." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79835.

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Thesis (MSc MedSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Background The QuantiFERON In-Tube (QFT IT) assay is an Interferon-gamma release assay (IGRA) which is currently used to detect Mycobacterium tuberculosis (M. tb) infection. It however cannot differentiate between latent infection and active tuberculosis (TB) disease. In an attempt to improve this tool to accurately diagnose active TB, the release of a variety of markers should be assessed in combination with Interferon gamma (IFN- γ). Luminex analysis was previously done on QFT plasma and promising candidates were

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12

Theodoulou, Frederica. "Studies on plant calmodulin-stimulated, calcium transporting ATPases, using biochemical and immunological techniques." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316850.

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13

Hurley, Ian Patrick Colles. "Detection of the adulteration of dairy products using immunological and DNA-based techniques." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439615.

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14

Mohd, Esa Norhaizan. "Immunological techniques applied to triacylglycerol rich lipoproteins in postprandial plasma and tissue slices." Thesis, University of Surrey, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340411.

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15

Baylet, Sandrine. "Techniques appliquées au diagnostic biologique des mycoses." Paris 5, 1999. http://www.theses.fr/1999PA05P205.

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16

Page, Susan. "Immunological and cultural techniques for determining numbers and activity of microorganisms inoculated into soil." Thesis, University of Kent, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359245.

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17

Wong, James Gilbert. "Immunological and inflammatory aspects of age-related macular degeneration measured by quantitative immunohistochemical techniques." Master's thesis, Sydney Medical School, 2004. http://hdl.handle.net/2123/14167.

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18

Zins, Pierre. "Intérêt de l'association de trois techniques d'agglutination pour la surveillance immunologique de la toxoplasmose." Paris 5, 1990. http://www.theses.fr/1990PA05P216.

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19

Elliott, Alicia Rochelle. "Immunological techniques for the serum determination of specific-IgE levels among workers exposed to seafood allergens." Thesis, Cape Technikon, 2003. http://hdl.handle.net/20.500.11838/1473.

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Thesis (MTech (Biomedical Technology))--Cape Technikon, 2003<br>Allergic conditions among workers processing seafood are most often related to inhalation of the seafood antigens or via direct unprotected handling of the seafood and its products. This can cause sensitised individuals to suffer from asthma, rhino-conjunctivitis, urticaria and protein contact dermatitis, which are IgE mediated. Food intolerance may also occur which is a non-IgE mediated reaction, however the exact mechanism is yet to be determined. There is therefore a need to develop reliable tests to identify sensitised wo

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20

Read, Mark N. "Statistical and modelling techniques to build confidence in the investigation of immunology through agent-based simulation." Thesis, University of York, 2011. http://etheses.whiterose.ac.uk/2174/.

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For over a century immunological research has made striding advancements that have substantially improved the wellbeing and longevity of the population. There remain, however, many pathogens and diseases to which the immune system and immunologists currently have no answer. Immunological research is as active now in understanding the immune system and its response as it ever has been. Extraordinary technological breakthroughs allow researchers to examine the genes and proteins expressed in individual cells, and the molecules expressed on their cell surfaces. Advancements in imaging techniques

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21

Pickles, Neil Anthony. "Characterisation and differentiation of Acacia species, gum ghatti and gum tragacanth exudates using chemical and immunological techniques." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486937.

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22

Chang, Yunsheng. "Evaluation of immunological techniques for host fish identification, and cryopreservation of embryos for conserving rare freshwater mussels." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-12052009-020208/.

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23

Zetterquist, Henrik. "The use of molecular techniques for identification of genetic divergence in transplantation : with special reference to MHC genes and HLA typing /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3267-0/.

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24

Drouet, Mireille. "Techniques de détection des molécules HLA solubles de classe 1 dans le plasma : étude de sujets sains et de transplantés." Limoges, 1993. http://www.theses.fr/1993LIMO0241.

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Le systeme hla est localise sur le bras court du chromosome 6 et code pour des molecules hla impliquees dans la reponse immune. Ces molecules existent sous forme transmembranaire et soluble. Nous avons mis au point des techniques de caracterisation des molecules hla de classe 1 solubles: dosage par test elisa, analyse moleculaire par western blot, et nous avons applique ces techniques a l'etude des plasmas de sujets sains et de transplantes renaux. Ces molecules presentent une grande diversite quantitative et qualitative. Les variations des concentrations dependent de facteurs genetiques, parm

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25

VIOLIN, KALAN B. "Implantes cerâmicos e metálicos - caracterização da osteointegração por imuno-histoquímica, lectina-histoquímica e marcadores fluorescentes." reponame:Repositório Institucional do IPEN, 2015. http://repositorio.ipen.br:8080/xmlui/handle/123456789/25300.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2015-12-10T17:29:01Z No. of bitstreams: 0<br>Made available in DSpace on 2015-12-10T17:29:01Z (GMT). No. of bitstreams: 0<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Tese (Doutorado em Tecnologia Nuclear)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP<br>FAPESP:10/20698-4

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26

Montfort, Patrick. "Étude écologique, immunologique et pathogénique des Aeromonas mobiles dans les milieux aquatiques et à travers différents systèmes épurateurs." Montpellier 2, 1987. http://www.theses.fr/1987MON20279.

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Evolutions spatio-temporelles des bacteries aeromonas dans des eaux superficielles et saumatres plus ou moins usees, et dans differents epurateurs des eaux usees. Distribution au sein du genre aeromonas, des especes a. Hydrophila, a. Caviae, et a. Sobria dans ces memes milieux

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27

Lake, Douglas Fletcher. "Construction and mutagenesis of an anti-insulin single chain Fv (scFv) using protein engineering techniques: Identification of peptide mimotopes which inhibit scFv-insulin binding." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186310.

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Peptide mimotopes were found using random peptide library technology (Selectide technology) which bind to the paratope of an anti-insulin monoclonal antibody. These peptides inhibit insulin from binding to the anti-insulin antibody, indicating that they share at least part of the paratope for insulin. The 50% inhibitory concentrations (IC50) of certain peptides were determined to be less than one order of magnitude from that of insulin. The immunoglobulin variable region genes of the anti-insulin antibody were rescued and cloned independently as V(H) and V(k). A single chain Fv (scFv) was cons

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28

BERNARDI, SERENA. "FLOW CYTOMETRY AND SUPPORTIVE TECHNIQUES FOR THE DIAGNOSIS AND CHARACTERIZATION OF FELINE LYMPHOPROLIFERATIVE DISEASES." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/707390.

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Flow cytometry (FC) is an immunophenotyping technique routinely applied in human medicine to assess the origin of hematopoietic malignancies, even if this is not its only use in human species. In veterinary medicine, its use in clinical practice mainly concerns with the evaluation of hematopoietic malignancies. However, this diagnostic tool is more widely and commonly applied in canine oncology, whereas in feline species there are many limitations for an extensive and routine use of this technique (Wilkerson et al., 2012; Guzera et al., 2016). One of the most relevant limitations for feline sp

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29

Johnson, Chrisopher W. A. "Design and development of a site specific protein patterning technique for use in a microfluidic antibody separation device." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/157341/.

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The rapid quantification of the concentration of different immunoglobulins classes from patient serum is required to diagnose patients in the early stages of sepsis. Microfluidic point of care technology can improve diagnostics by decreasing the analysis time, and integrating parallel analysis in a single portable device. The design of a novel method to fabricate surfaces presenting multiple micron scale protein motifs, for integration within a microfluidic channel device, is described in this thesis. Initial research focussed on conjugating protein motifs on silicon <100> substrates in micron

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30

Clingen-Vance, Hilary Joanna. "Studies on the effect of low level laser therapy on bone repair." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324832.

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31

Arnold, Vincent. "Etude des interactions entre les cellules tueuses naturelles et les cellules dendritiques dans le cadre de l'infection par le VIH-1." Paris 7, 2010. http://www.theses.fr/2010PA077125.

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Nous nous sommes intéressés au dialogue NK-DC dans le contexte d'infection VIH-1 et dans le cadre d'une vaccination anti-VIH-1. A l'aide d'un système de co-culture autologue NK-DC infectées in vitro par le VIH-1, notre objectif était de déterminer l'impact de l'infection des DC par le VIH-1 sur les fonctions effectrices des cellules NK, et le contrôle éventuel exercé par les cellules NK de l'infection des DC par le VIH-1. Nous avons observé suite à l'infection VIH-1 des DC des changements dans l'expression du récepteur NK CD85J. Nous avons également observé une forte capacité à contrôler la ré

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32

Maietta, Antonio. "Assessing the efficiency of In Vivo electroporation as a nonviral gene transfer technique and studying its application in antiangiogenic cancer gene therapy and cancer immunotherapy." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31267.

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Electroporation refers to a technique that makes use of electrical pulses to create transient and reversible pores into cellular membranes which allows the passage of drugs and macromolecules, such as plasmid DNA, into the cell's interior. It is a widely used laboratory procedure for the transfection of cultured mammalian cells, plant cells and bacteria. Only recently has in vivo electroporation been used for the transfer of genetic material into living tissue, such as muscle, hepatocytes, and tumors of experimental animals. Using a luciferase assay, we have shown that electroporation-mediated

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33

Hultén, Cecilia. "Serum amyloid A (SAA) as a marker of inflammation in the horse : biochemical, experimental and clinical studies /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5449-2.pdf.

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34

Dernfalk, Johanna. "Multiplex flow cytometric assays for markers of inflammation : development and application in bovine samples /." Uppsala : Dept. of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/20085.pdf.

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35

Tsugiyama, Lucila Emiko. "Análise de áreas encefálicas ativadas em pombos por estímulos magnéticos e olfativos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-23052014-093902/.

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Dentre as hipóteses para explicar mecanismos utilizados por pombos-correios para se orientar e navegar no espaço destacam-se a utilização de dois fatores ambientais: gradientes de odores específicos na atmosfera e o campo geomagnético. Para determinar se há diferenças ou correlações entre áreas cerebrais envolvidas com as vias sensoriais olfatória e magnética, utilizou-se imunohistoquímica e gene de resposta imediata ZENK. Dois grupos foram expostos a estímulos olfatórios, mas um com oclusão de narinas. Um grupo foi exposto ao estímulo magnético variando em direção e intensidade semelhante ao

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36

Germond, Laurence. "Trois principes de coopération pour la segmentation en imagerie de résonnance magnétique cérébrale." Phd thesis, Université Joseph Fourier (Grenoble), 1999. http://tel.archives-ouvertes.fr/tel-00004835.

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Le travail présenté dans ce document a pour but la mise en oeuvre d'un système de segmentation d'Images de Résonance Magnétique (IRM) cérébrales qui permette de tirer parti de plusieurs approches complémentaires en réponse à la complexité du problème posé. Face à la diversité des approches existant pour la segmentation (classification, modèles déformables,...) nous montrons que l'on peut définir un cadre de travail commun qui permette la mise en oeuvre de coopération entre des approches hétérogènes. Le cadre méthodologique que nous avons défini s'articule autour des notions d'apprentissage et

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37

Garnier, Gérard. "Le facteur B du complément humain : bases structurales et biosynthétiques de sa microhétérogénéité, mises en évidence par les techniques électrophorétiques." Rouen, 1988. http://www.theses.fr/1988ROUES026.

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38

HERIGAULT, GWENAEL. "Spectroscopie rmn du proton in vivo a 1 ou 2 dimensions frequentielles. Application au cerveau de rat tumoral." Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE10157.

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Ce travail a pour objectif de mettre en place des techniques de spectroscopie rmn du proton localisee, et de developper des techniques a deux dimensions frequentielles (2d), en vue d'etudier un modele de gliome intracerebral chez le rat. Une technique de localisation mono-voxel (press) a ete implementee afin de mesurer les temps de relaxation longitudinaux et transversaux des principaux metabolites visibles par rmn dans le cerveau de rat. L'implementation d'une sequence d'imagerie spectroscopique multi-tranches multi-echos a ensuite permis d'obtenir la distribution des principaux metabolites p

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39

Chawalit, Kritpetchrarut Sophark Rojanasthien. "A new competitive inhibition technique for determination of plasma fibronectin activity and plasma fibronectin in B-thalassemia/HbE ; The role of plasma fibronectin as a non-immunological opsonin to promote monocyte phagocytic function in B-thalassemia HbE /." abstract, 1986. http://mulinet3.li.mahidol.ac.th/thesis/2529/29E-Chawalit-K.pdf.

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40

Seedhom, Mina O. "Immunity, Pathogenesis, and Prevention of Poxvirus Infections: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/514.

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Vaccinia virus (VAC) is the prototypical member of the orthopoxvirus genus of the poxvirus family and the virus used for smallpox vaccinations. The following describes the testing of VAC variants designed to have similar immuno-protective profiles with decreased pathogenicity, examines the immune response to VAC after lethal infection in wild type and lupus-prone mice, and describes a method that allows for the enumeration of VAC-specific CD8+ T in naïve and VAC-immune mice. The first part describes work examining VAC Wyeth (VAC-Wy) variants engineered to be less pathogenic in vivo. VAC-Wy var

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Kishko, Michael G. "Molecular and Functional Properties of Transmitted HIV-1 Envelope Variants: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/519.

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In 2008 the Nobel Prize in Physiology or Medicine was awarded to the co-discoverers of the Human Immunodeficiency Virus Type 1 (HIV-1), the causative agent of Acquired Immunodeficiency Syndrome (AIDS). This award acknowledged the enormous worldwide impact of the HIV-1/AIDS pandemic and the importance of research aimed at halting its spread. Since the syndrome was first recognized, 25 million people have succumbed to AIDS and over 33 million are currently infected with HIV-1 (www.unaids.org). The most effective strategy for ending the pandemic is the creation of a prophylactic vaccine. Yet, to

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42

Malaman, Maria Fernanda. "Avaliação diagnóstica do exantema máculo-papular e urticária tardia induzidos por antibióticos beta-lactâmicos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-17102014-123017/.

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Os antibióticos beta-lactâmicos, principalmente as aminopenicilinas (ampicilina e amoxicilina) são causa freqüente de exantema maculo papular e urticária tardia em pacientes tratados com estes medicamentos. Entretanto, a falta de métodos para diagnóstico destas reações constitui uma lacuna na abordagem destes indivíduos. Objetivos: Os objetivos deste estudo foram determinara a freqüência e significância de testes cutâneos positivos em pacientes com história de exantema maculo-papular e urticária tardias induzidos por antibióticos beta-lactâmicos e determinar a sensibilidade e especificade dos

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Rabehi, Amine. "Electromagnetic microsystem for the detection of magnetic nanoparticles in a microfluidic structure for immunoassays." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS129/document.

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La détection et quantification d’agent biologique occupe une place prépondérante dans la prévention et la détection des dangers possibles pour la santé publique (épidémie ou pandémie), l’environnement ainsi que d’autres risques contextuelles (bioterrorisme, armes biologique ou chimiques…etc.). Par conséquent, le développement d’un système portable et à moindre coût permettant de détecter ces dangers constitue l’axe de recherche pluridisciplinaire de la collaboration entre différents laboratoires de l’UPMC (Paris 6) et « RWTH university » à Aachen en Allemagne. Dans ce projet, nous avons étudié

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44

Piarroux, Raphaël. "Développement de tests de diagnostic in vitro appliqués au sérodiagnostic des infections fongiques par western blot et immunochromatographie." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0763/document.

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Le champignon microscopique Aspergillus fumigatus provoque un nombre important de maladies graves. Parmi elles, l’aspergillose pulmonaire chronique (APC) et l’aspergillose broncho-pulmonaire allergique (ABPA) affectent 3 et 4,8 millions de personnes dans le monde, respectivement.L’APC est très souvent mortelle si elle n’est pas soignée. Elle se développe très souvent après une tuberculose. C’est donc une maladie des pays émergents, où il n’est souvent pas possible de la diagnostiquer à cause du coût trop important des techniques existantes.L’ABPA est une complication très grave de l’asthme et

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Cerf-Bensussan, Nadine. "Etude des lymphocytes intraepitheliaux de l'intestin chez l'homme et le rat." Paris 7, 1987. http://www.theses.fr/1987PA077045.

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46

Hall, Aaron A. "Immunomodulatory Effects of Novel Therapies for Stroke." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003109.

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47

Delgado, Livia. "Fenômeno de epitope spreading: caracterização clínico imunológica em pacientes portadores de dermatoses bolhosas autoimunes." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-04082016-162013/.

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INTRODUÇÃO: As dermatoses bolhosas autoimunes são um grupo heterogêneo de afecções da pele e/ou mucosas associadas à produção de autoanticorpos dirigidos às moléculas de adesão epitelial. Podem ser classificadas em dermatoses bolhosas intraepidérmicas (pênfigos) ou subepidérmicas (penfigóides, epidermólise bolhosa adquirida). Nos últimos anos, a transição entre dermatoses bolhosas autoimunes ou coexistência de autoanticorpos de diferentes dermatoses têm sido relatadas em alguns pacientes e atribuída ao fenômeno de epitope spreading (ES): a diversificação de epítopos reconhecidos pelo sistema i

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48

Vaine, Michael. "Antibody Responses Elicited by DNA Prime-Protein Boost HIV Vaccines: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/462.

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The best known correlate of protection provided by vaccines is the presence of pathogen specific antibodies after immunization. However, against the Human Immunodeficiency Virus-1 (HIV-1) the mere presence of antibodies specific for the viral Envelope (Env) protein is not sufficient to provide protection. This necessitates in depth study of the humoral responses elicited during infection and by vaccination. While a significant amount of effort has been invested in studying the evolution of antibody responses to viral infection, only limited progress in understanding antibody responses elicited

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Madera, Rachel F. "RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/644.

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Abstract:

Virus infection is sensed by the innate immune system through germline encoded pattern recognition receptors (PRRs). Toll-like receptors (TLRs), retinoic acid-inducible gene-I-like receptors (RLRs) and nucleotide-binding oligomerization domain-like receptors (NLRs) serve as PRRs that recognize different viral components. Microbial nucleic acids such as Ribonucleic acid (RNA) are important virus-derived pathogen-associated molecular patterns (PAMPs) to be recognized by PRRs. Virus recognition may occur at multiple stages of the viral life cycle. Replication intermediates such as single-stranded

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Leslie, Kevin A. "Evaluation and Adaptation of Live-Cell Interferometry for Applications in Basic, Translational, and Clinical Research." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5562.

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Abstract:

Cell mass is an important indicator of cell health and status. A diverse set of techniques have been developed to precisely measure the masses of single cells, with varying degrees of technical complexity and throughput. Here, the development of a non-invasive, label-free optical technique, termed Live-Cell Interferometry (LCI), is described. Several applications are presented, including an evaluation of LCI’s utility for assessing drug response heterogeneity in patient-derived melanoma lines and the measurement of CD3+ T cell kinetics during hematopoietic stem cell transplantation. The charac

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