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Relevant bibliographies by topics / Immunology and Allergy / Dissertations / Theses

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Dissertations / Theses on the topic 'Immunology and Allergy'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Sjögren, Ylva. "Early infant gut flora and neutral oligosaccharides in colostrum in relation to allergy development in children." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7152.

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<p>Today, atopic allergy is the most common chronic disease among children in the developed world. The increase in allergy prevalence during the past decades in these countries might be associated with lower microbial exposure. The gut flora, consisting of approximately 800 different species of bacteria, has been postulated to be important for the development of a fully functional immune system. Essentially, these bacteria are in constant contact with the gut flora associated lymphoid tissue, the largest lymphoid tissue of the human body. Following birth, the sterile gut of the newborn is imme

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2

Kronqvist, Marianne. "Clinical and immunological studies of respiratory allergy among farmers : with focus on dust mite allergy /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4411-3/.

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3

Thang, Cin. "Investigation of intervention strategies for Ig-E mediated food allergy in a murine model of cow's milk allergy." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119562.

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Food allergy, an immune-mediated adverse hypersensitivity reaction to ingested food, is an emerging global health problem that not only causes the disease to susceptible individuals but also causes psychological impacts and financial damage to their families. Food allergy incidence is significantly increased in the past decade and currently estimated at 6-8% in 1 year old children, and 2-4% in older children and adults. Food allergy is the leading cause of anaphylaxis in children and severe cases may lead to fatal anaphylaxis reactions. Although continuous efforts have been made to better unde

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4

Minang, Jacob. "Cytokine responses in metal-induced allergic contact dermatitis : Relationship to in vivo responses and implication for in vitro diagnosis." Doctoral thesis, Stockholm : Dept. of Immunology, Wenner-Gren Institute, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-717.

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5

Klaesson, Sven. "Immune modulatory effects of intravenous immunoglobulin in vitro and after allogeneic bone marrow transplantation /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2636-0.

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6

Barbieri, Bruno. "Novel aspects of p-aminobenzoic acid metabolism in connection with arachidonic acid oxidation in human lymphoid cells and platelets /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2679-4.

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7

Larsson, Susanne. "Human cytomegalovirus (HCMV) : detection and elimination of infected blood cells in vitro, immune reactivity and complications following HCMV infection /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2883-5.

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8

Kumagai-Braesch, Makiko. "Immunological characterisation of human anti-pig responses in vitro /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2959-9.

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9

Hammarström, Viera. "B-cell immunity in patients with hematological malignancies and after stem cell transplantation : studies with special reference to tetanus and pneumococcal immunity /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980828hamm.

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10

Zetterquist, Henrik. "The use of molecular techniques for identification of genetic divergence in transplantation : with special reference to MHC genes and HLA typing /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3267-0/.

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11

Huang, DeRen. "Genetic control of myasthenia gravis : a study on cytokine and co-stimulator genes and their related functions /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3478-9/.

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12

Elkarim, Rihab A. "Potential role of anti-cytokine autoantibodies in the regulation of cytokine responses in infections and autoimmune diseases /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3774-5/.

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13

Gough, Lucy. "The proteolytic activity of the mite allergen Der p 1 enhances IgE synthesis : studies in mice showing a link between allergenicity and cysteine protease activity." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342508.

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14

Boyd, Peter. "Hapten-mediated contact allergy : a proteomic and immunological approach." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/369220/.

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Allergic contact dermatitis (ACD) is a prevalent skin condition caused by chemical haptens, which enter the epidermis, and by modifying self-proteins, render them immunogenic via the activation of hapten-specific T-cells. It is currently not known which specific protein modifications are responsible for sensitization. This work investigates the extreme sensitizer DNCB, which confers a dinitrophenyl (DNP) protein modification. Immortalised keratinocytes (HaCaT), incubated with DNCB were compared to ex vivo human skin using immunofluorescence and western blot detection of DNP-proteins, showing w

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15

Musaad, Salma MA. "Anthropometric Measures of Obesity and the Association with Asthma and Other Allergic Disorders: Cincinnati Children’s Allergy and Immunology Clinic Cohort." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1192570691.

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16

See, Sarah Bihui. "Outer membrane protein immunity to Pasteurella pneumotropica and the interaction of allergy." University of Western Australia. School of Paediatrics and Child Health, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0103.

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[Truncated abstract] Infectious and allergic diseases of the respiratory tract are major contributors to global mortality, morbidity and economic burden. Bacterial infections such as pneumonia and otitis media are important diseases, especially in children, while allergic diseases such as asthma and allergic rhinitis afflict up to 30% of the world's population. A confounding aspect of respiratory disease is the evidence of a complex relationship between respiratory allergy and respiratory infection, with infection suggested to both promote and prevent the pathogenesis of allergic disease. Addi

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17

Lee, Eric Cheuk Kin. "Characterising the clinical phenotype and immunopathophysiology of food protein-induced enterocolitis syndrome in Australian children." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24080.

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FPIES is an uncommon food allergic disorder in infants and children. It differs clinically from IgE-mediated food allergy presenting acutely with delayed profuse vomiting, at times with lethargy, pallor, floppiness and diarrhoea. The diagnosis is difficult as it is based on clinical criteria, with no diagnostic test aside from oral food challenge. There is geographic variation in demographic features and the immunopathophysiology of FPIES is largely unknown. In this thesis, a retrospective study was undertaken to characterise the demographic and clinical phenotype of FPIES in Australian childr

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18

Cederbrant, Karin. "The primary lymphocyte culture in the diagnosis of drug- and metal-induced allergy /." Linköping : Univ, 2000. http://www.bibl.liu.se/liupubl/disp/disp2000/med635s.pdf.

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19

Montan, Per. "Immunological and inflammatory mechanisms in ocular allergy with special reference to vernal keratoconjunctivitis : clinical and experimental studies /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4170-X/.

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20

Järvinen, Kirsi-Marjut. "Human milk immunology in relation to the development of cow's milk allergy in the breast-fed." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/jarvinen/.

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21

Breckler, Liza Anne. "The role of maternal-fetal interactions on the aetiology of allergic disease." University of Western Australia. School of Paediatrics and Child Health, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0042.

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[Truncated abstract] The dramatic increase in the expression of allergic diseases such as asthma and allergy over the last 20-30 years has highlighted the urgent need to identify causative factors. It was hypothesised that direct immune interactions between mother and fetus contribute to the cytokine milieu of pregnancy, thus influencing immune maturation after birth. Further it was speculated that the cytokine responses produced as a result of maternalfetal interactions are Th-2 skewed in women allergic disease, which programmes their offspring towards developing an allergic phenotype after b

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22

Liang, Juan. "A Nonlinear Mixed Modeling Method to Analyze Allergen Assay Data and the Effects of Exposures Two Indoor Aeroallergens During Infancy on Children at Age Three: The CCAAPS Cohort." Cincinnati, Ohio : University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1245413088.

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Thesis (Ph.D.)--University of Cincinnati, 2009.<br>Advisor: Paul Succop. Title from electronic thesis title page (viewed Dec. 15, 2009). Keywords: Nonlinear; Immunoassay; Allergen; Allergy. Includes abstract. Includes bibliographical references.

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23

Azzaoui, Imane. "CCL18 et réponse régulatrice, de la situation physiologique à l'atopie." Thesis, Lille 2, 2011. http://www.theses.fr/2011LIL2S019/document.

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Les chimiokines sont un élément essentiel du trafic cellulaire aussi bien homéostatique que dans des situations pathologiques. Outre cette fonction chimiotactique spécifique à ce type de molécules, on leur a récemment attribué une implication dans le profil de polarisation de la réponse adaptative spécifique, en agissant directement sur les lymphocytes T (Lc T) ou indirectement par le biais des cellules dendritiques (DC). CCL18 est une chimiokine exprimé préférentiellement au niveau pulmonaire et de façon moindre au niveau ganglionnaire, capable d’attirer les DC et les Lc T, elle est induite p

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24

Qaseem, Asif Shehzad. "Modulation of immune cell functions by human lung surfactant protein SP-D in allergic asthma." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/13893.

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Lung surfactant protein D (SP-D) is a soluble pattern recognition and innate immune molecule, which has been shown to be protective against lung infection, allergy, asthma and inflammation. SP-D is composed of an N-terminal collagen region and a homotrimeric, C-terminal carbohydrate binding domain (CRD). A recombinant form of trimeric CRD region (rhSP-D) has been shown to offer protection against asthma and inflammation in murine models by bringing down IgE levels, eosinophilia, and causing T helper cell polarisation from a pathogenic Th2 to a protective Th1 phenotype. Thus, rhSP-D can provide

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25

Lorgat, Faizel. "Proliferative and cytotoxic cellular immune responses in human tuberculosis." Thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/26373.

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26

Eliasson, Hanna. "Development of immunological methods and Real-Time PCR for detection of Macadamia nut (Macadamia spp.)." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6150.

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<p>A new European labeling directive (2003/89/EC) states that certain foods and products derived thereof must always be declared. Among the tree nuts specified is Macadamia nut (Macadamia spp.). During the last few years, cases of IgE-allergic reactions, even severe anaphylaxes, have been reported. Reliable methods for the detection of this nut are needed.</p><p>Protein from Macadamia nuts was isolated. Polyacrylamide gel electrophoresis in SDS revealed two main protein bands of about 20 and 50kDa. These protein bands were cut and extracted from the gel and rabbits were immunized with each pro

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27

Mhike, Morgen. "Characterization of Methylene Diphenyl Diisocyanate Protein Conjugates." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/1844.

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Diisocyanates (dNCO) such as methylene diphenyl diisocyanate (MDI) are used primarily as cross-linking agents in the production of polyurethane products such as paints, elastomers, coatings and adhesives, and are the most frequently reported cause of chemically induced immunologic sensitization and occupational asthma (OA). Immune mediated hypersensitivity reactions to dNCOs include allergic rhinitis, asthma, hypersensitivity pneumonitis and allergic contact dermatitis. There is currently no simple diagnosis for the identification of dNCO asthma due to the variability of symptoms and uncertain

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28

Wu, Qi Xuan. "Immunobiology of peptides from venom of the jumper ant Myrmecia pilosul." Thesis, The University of Sydney, 2001. https://hdl.handle.net/2123/28045.

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Ants from genus Myrmecia, subfamily Myrmeciinae, are aggressive stinging insects with medical importance in Australia, especially in the endemic areas of southeast Australia and Tasmania. Venoms of Myrmecia ants can cause allergic reactions with symptoms ranging from local to systemic. In some sensitized individuals of extreme severity, even death can occur. Two major allergens, Myr p 1 and Myr p 2 had been cloned and characterized from venom of one species, Myrmecia pilosula. The aim of this thesis was to study several aspects of the allergens from venoms of Myrmecia ants.

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29

Pelletier, Benjamin. "Modulation de la tolérance immunitaire par l'immunothérapie dans l'allergie alimentaire et en oncologie." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ049.

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Les immunothérapies font partie des nouveaux traitements thérapeutiques les plus efficaces utilisés dans les domaines de l'allergie et l'oncologie. Cependant, leur rôle dans ces deux pathologies est contradictoire. Dans le premier cas, le but recherché est de rétablir une tolérance immunitaire alors que dans le second, ce traitement est appliqué afin de lever l'environnement immunosuppressif présent dans la tumeur. Notre intention dans ce travail consiste à identifier les populations cellulaires mises en cause dans ces deux modèles et de mettre en évidence la dérégulation immunologique conduis

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30

Hillson, William Rawstron. "The role of thermal processing and protein oxidation in peanut allergy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:88d64b79-a7e6-4e41-acee-47c215d39f6b.

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Food allergies are an increasing health problem throughout the developed world. Among these, peanut allergy is particularly significant, due to its exceptional severity and frequent lifelong duration. Much of its aetiology remains unclear. In particular, it remains unknown why, unlike other food allergies, peanut allergy incidence correlates poorly with average dietary peanut consumption. A popular explanation for this discrepancy is that peanut allergy is more common in regions where predominantly dry-roasted (DR) peanuts are consumed, leading to speculation that DR-induced chemical modificat

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31

Oliveira, Raquel Soares Binotti de. "Atividade acaricida contra ácaros Dermatophagoides pteronyssinus e D. farinae (Pyroglyphidae) de produto contendo óleos essenciais de Lavadula officinalis e Mentha piperita (Labiatae)." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308185.

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Orientador: Ângelo Pires do Prado<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-16T09:23:48Z (GMT). No. of bitstreams: 1 Oliveira_RaquelSoaresBinottide_D.pdf: 2064191 bytes, checksum: 947400e01f2da61b9ec537f4350e8793 (MD5) Previous issue date: 2009<br>Resumo: Ácaros são os principais agentes relacionados ao quadro de sensibilização respiratória de indivíduos atópicos no Brasil, sendo responsáveis por crises de asma, rinite e conjuntivite alérgicas, dentre outros. São encontrados nas residências principalmente em

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32

Lu, Thomas X. "MicroRNA in the Pathogenesis of Allergic Inflammation." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1329935942.

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33

Travers, Jared. "Altered Esophageal Epithelial Differentiation in EoE and Regulation of IL-1 Cytokine Responses by Chromatin." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504802854888675.

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34

Sjögren, Ylva Margareta. "Early-life gut microbiota and breast milk oligosaccharides in relation to childhood immune maturation and allergy." Doctoral thesis, Stockholms universitet, Wenner-Grens institut för experimentell biologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-26781.

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Atopic allergy is the most common chronic disease among children in the developed world. This high prevalence could be associated with low microbial exposure. The early gut microbiota appears to be important for immune maturation. Immunomodulatory components in human milk might differ between mothers and could therefore explain the contradictory results seen regarding breastfeeding and allergy development. The aim of this thesis was to investigate whether early colonization with certain gut microbiota species influences childhood immune responses and allergy development up to age five. Also, a

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35

Raman, Kavita. "Regulation of interferon-gamma production in human peripheral blood mononuclear cells: Heredity, relation to markers of allergy and possible role of inducible T cell kinase (ITK)." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289221.

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IFN-γ and IL-4 are cytokines that are thought to be products of distinct differentiation pathways for lymphocytes and that inhibit and enhance the development of IgE antibodies, respectively. We hypothesized that the level of IFN-γ production upon stimulation of immune cells in the blood is a stable, heritable phenotype that is inversely related to phenotypic markers of allergy and to the Th2 cytokine IL-4. The studies were performed with samples of human blood obtained from children enrolled at birth in a large, longitudinal study of allergy known as the Tucson CRS. Mitogen-stimulated IFN-γ p

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36

Reddy, Keerthi C., Mary Kearns, S. Alvarez-Arango, et al. "YouTube and Food Allergy: An Appraisal of the Educational Quality of Information." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/115.

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37

Coley, Rose Michelle. "The Association of Cancer Development in Patients with Systemic Lupus Erythematosus." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2148.

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The Association of Cancer Development in Patients with Systemic Lupus Erythematosus by Rose Michelle Coley MPH, Walden University, 2011 BS, University of Mount Olive, 2008 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Health Walden University March 2016 Both cancer and autoimmune diseases have been associated with numerous factors that may independently lead to the development of either disease. When these factors overlap the difficulty in assessing association is compounded. The numerous factors that are thought to cause system

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38

Medeiros, Marcell Costa de. "Modulação da imunidade adaptativa por produtos solúveis de células de carcinoma espinoceular de cabeça e pescoço (HNSCC) : um papel da galanina derivada do tumor? /." Araraquara, 2016. http://hdl.handle.net/11449/138922.

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Orientador: Carlos Rossa Junior<br>Banca: Alexandra Ivo de Medeiros<br>Banca: Luis Carlos Spolidorio<br>Banca: Ricardo Della Coletta<br>Banca: Roseanas Almeida Freitas<br>Resumo: Carcinoma espinocelular de cabeça e pescoço (HNSCC, squamous cell carcinoma of the head and neck) é uma neoplasia caracterizada mais comumente por invasão local/regional de prognóstico sombrio quando diagnosticada em estágios avançados e uma característica imunossupressão local ou sistêmica associada. A taxa de sobrevivência em casos avançados é inferior à de câncer de mama ou próstata, e seu tratamento usualmente cau

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39

Burgess, Stacey L. "A specific component of the intestinal microbiota exacerbates the severity of allergic asthma." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368026710.

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Yamani, Amnah. "Dysregulation of Vascular Endothelial Function Modulates Severity of IgE-mediated Anaphylactic Reactions." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490350649626552.

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Lotfi-Emran, Sahar. "Transformation of human mast cells by interferon-gamma and the potential role of myeloid derived suppressor cells in mastocytosis." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/4077.

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Mast cells respond to a variety of signals, are associated with both increased inflammation and regulation of the immune response, and are able to interact with a variety of hematopoietic and non-hematopoietic cells. The majority of the work that highlights mast cell pleiotropic abilities has been completed in murine models. Though these models have significantly advanced our understanding of what mast cells can do, they cannot inform us as to what mast cells actually do in human beings. The goal of this dissertation is to assess fully mature, primary human mast cell function beyond the well-d

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42

Noakes, Paul Stanton. "The effects of maternal smoking on infant immune development." University of Western Australia. School of Paediatrics and Child Health, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0080.

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[Truncated abstract] With the dramatic rise in asthma and allergic disease there is an urgent need to define the early life exposures which influence developing immune responses to increase the predisposition to allergic disease. While this is clearly multifactorial, this thesis addresses the effects of maternal smoking as a major adverse, yet avoidable exposure in early life. I hypothesised that the well-documented increased susceptibility to infection in infants of smokers could indicate underlying effects on innate Toll-like receptor (TLR) mediated microbial responses which could in turn c

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43

Yokoyama, Nicole Hune. "Sensibilização ao extrato de Blomia tropicalis, na ausência de alum, requer a molécula adaptadora MyD88." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-11072014-111650/.

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Exposição a alérgenos de poeira doméstica é fator de risco para o desenvolvimento de doenças alérgicas. Os objetivos foram estudar a resposta inflamatória pulmonar alérgica induzida pela sensibilização i.n. ou s.c. ao extrato do ácaro Blomia tropicalis (Bt) e avaliar a participação da molécula adaptadora Myd88. Animais C57BL/6 sensibilizados com solução de extrato de Bt adsorvido ao alum exibiram altos níveis de IgE e aumento do número de eosinófilos. Contudo, animais sensibilizados apenas com Bt não apresentaram aumento dos níveis de IgE. Assim, animais C57BL/6 ou MyD88KO foram sensibilizados

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44

Gudimetla, Vishnu. "Mechanisms of Allergic Sensitization and Desensitization in a Mouse Model." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1529667182585476.

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Gonzalez, Tammy. "Investigating the Role of the Human Microbiome in the Pathogenesis of Atopic Dermatitis in the Mechanisms of the Progression of Atopic Dermatitis to Asthma in Children (MPAACH) Cohort." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268717032036.

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46

Victor, Jefferson Russo. "Mecanismos regulatórios mediados pelos anticorpos maternos na modulação da resposta de hipersensibilidade do tipo I ao alérgeno ovalbumina em camundongos neonatos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-25032009-171427/.

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Avaliamos os mecanismos regulatórios desencadeados pela imunização materna na resposta alérgica da prole OVA. A imunização materna com OVA promoveu alterações como o aumento da expressão dos receptores FcgRIIb nos linfócitos B esplênicos dos neonatos aos 3 dias de idade (d.i.), o que se manteve até os 20 d.i. Com a imunização das proles no período neonatal a imunização materna inibiu a produção de anticorpos IgE anti-OVA. Além disso, foi observado na população de linfócitos B da prole o aumento da expressão dos receptores FcgRIIb e CD44. A transferência passiva de IgG de mães imunes no pós-nat

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Elliott, Alicia Rochelle. "Immunological techniques for the serum determination of specific-IgE levels among workers exposed to seafood allergens." Thesis, Cape Technikon, 2003. http://hdl.handle.net/20.500.11838/1473.

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Thesis (MTech (Biomedical Technology))--Cape Technikon, 2003<br>Allergic conditions among workers processing seafood are most often related to inhalation of the seafood antigens or via direct unprotected handling of the seafood and its products. This can cause sensitised individuals to suffer from asthma, rhino-conjunctivitis, urticaria and protein contact dermatitis, which are IgE mediated. Food intolerance may also occur which is a non-IgE mediated reaction, however the exact mechanism is yet to be determined. There is therefore a need to develop reliable tests to identify sensitised wo

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48

Groschwitz, Katherine R. "Mast cell-mediated intestinal barrier function in homeostasis and disease." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291389792.

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Damle, Sheela Ruby. "TYPE 2 IMMUNE RESPONSES IN THE CONTEXT OF HELMINTH INFECTION, ASTHMA, DENDRITIC CELLS, AND MYELOID DERIVED SUPPRESSOR CELL FUNCTION." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4696.

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Type 2 (TH2) immune responses evolved to respond to helminth parasite infections by the production of TH2 cytokines, which stimulate anti-helminth immunity. Macrophage migration inhibitor factor (MIF) is a pleiotropic cytokine, which is produced by many cell types. We demonstrate that mice deficient in MIF have enhanced clearance of a helminth parasite. MIF deficiency in CD4+ T cells was found to be the most important for mediating parasite clearance. We mimicked MIF deficiency by administering an inhibitor of the MIF tautomerase activity, sulforaphane, and this also increased parasite clearan

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Vinot, Pierre-Axel. "Développement de pseudo-particules rétrovirales comme vaccin tolérogène et application dans l'allergie alimentaire." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS268.

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Abstract:

L’incidence croissante des désordres immunitaires a motivé le développement de nouvelles approches permettant l’induction d’une tolérance immunitaire spécifique et maintenue dans le temps. S’inscrivant dans ce cadre, la vaccination tolérogène exploite les propriétés innées du système immunitaire pour rétablir la tolérance en visant spécifiquement les cellules dendritiques et les lymphocytes T régulateurs. Ce concept se confronte néanmoins à certaines limitations dues au besoin d’apporter l’antigène sous une forme particulière ou de manière combinée avec un signal de tolérance. En exploitant le

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