Log in

Relevant bibliographies by topics / Immunology; Molecular dynamics / Journal articles

To see the other types of publications on this topic, follow the link: Immunology; Molecular dynamics.

Journal articles on the topic 'Immunology; Molecular dynamics'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Immunology; Molecular dynamics.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Stavrakoudis, Athanassios. "Conformational Flexibility in Designing Peptides for Immunology: The Molecular Dynamics Approach." Current Computer Aided-Drug Design 6, no. 3 (2010): 207–22. http://dx.doi.org/10.2174/157340910791760073.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Kortkhonjia, Ekaterine, Relly Brandman, Joe Zhongxiang Zhou, et al. "Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations." mAbs 5, no. 2 (2013): 306–22. http://dx.doi.org/10.4161/mabs.23651.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Grossman, Zvi, Charles L. Greenblatt, and Irun R. Cohen. "Parasite immunology and lymphocyte population dynamics." Journal of Theoretical Biology 121, no. 2 (1986): 129–39. http://dx.doi.org/10.1016/s0022-5193(86)80088-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Mallik, Buddhadeb, and Dimitrios Morikis. "Applications of Molecular Dynamics Simulations in Immunology: A Useful Computational Method in Aiding Vaccine Design." Current Proteomics 3, no. 4 (2006): 259–70. http://dx.doi.org/10.2174/157016406780655568.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Lopes, António M., and José A. Tenreiro Machado. "Symmetry in Complex Systems." Symmetry 12, no. 6 (2020): 982. http://dx.doi.org/10.3390/sym12060982.

Full text

Abstract:

Complex systems with symmetry arise in many fields, at various length scales, including financial markets, social, transportation, telecommunication and power grid networks, world and country economies, ecosystems, molecular dynamics, immunology, living organisms, computational systems, and celestial and continuum mechanics [...]

APA, Harvard, Vancouver, ISO, and other styles

6

Dongmo Foumthuim, Cedrix J., Alessandra Corazza, Rodolfo Berni, Gennaro Esposito, and Federico Fogolari. "Dynamics and Thermodynamics of Transthyretin Association from Molecular Dynamics Simulations." BioMed Research International 2018 (June 5, 2018): 1–14. http://dx.doi.org/10.1155/2018/7480749.

Full text

Abstract:

Molecular dynamics simulations are used in this work to probe the structural stability and the dynamics of engineered mutants of transthyretin (TTR), i.e., the double mutant F87M/L110M (MT-TTR) and the triple mutant F87M/L110M/S117E (3M-TTR), in relation to wild-type. Free energy analysis from end-point simulations and statistical effective energy functions are used to analyze trajectories, revealing that mutations do not have major impact on protein structure but rather on protein association, shifting the equilibria towards dissociated species. The result is confirmed by the analysis of 3M-T

APA, Harvard, Vancouver, ISO, and other styles

7

Mills, David M., and John C. Cambier. "B lymphocyte activation during cognate interactions with CD4+ T lymphocytes: molecular dynamics and immunologic consequences." Seminars in Immunology 15, no. 6 (2003): 325–29. http://dx.doi.org/10.1016/j.smim.2003.09.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Klinke, David J., and Qing Wang. "Understanding Immunology via Engineering Design: The Role of Mathematical Prototyping." Computational and Mathematical Methods in Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/676015.

Full text

Abstract:

A major challenge in immunology is how to translate data into knowledge given the inherent complexity and dynamics of human physiology. Both the physiology and engineering communities have rich histories in applying computational approaches to translate data obtained from complex systems into knowledge of system behavior. However, there are some differences in how disciplines approach problems. By referring to mathematical models as mathematical prototypes, we aim to highlight aspects related to the process (i.e., prototyping) rather than the product (i.e., the model). The objective of this pa

APA, Harvard, Vancouver, ISO, and other styles

9

Yamashita, Takefumi. "Toward rational antibody design: recent advancements in molecular dynamics simulations." International Immunology 30, no. 4 (2018): 133–40. http://dx.doi.org/10.1093/intimm/dxx077.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Loeffler, Dirk, and Timm Schroeder. "Understanding cell fate control by continuous single-cell quantification." Blood 133, no. 13 (2019): 1406–14. http://dx.doi.org/10.1182/blood-2018-09-835397.

Full text

Abstract:

Abstract Cells and the molecular processes underlying their behavior are highly dynamic. Understanding these dynamic biological processes requires noninvasive continuous quantitative single-cell observations, instead of population-based average or single-cell snapshot analysis. Ideally, single-cell dynamics are measured long-term in vivo; however, despite progress in recent years, technical limitations still prevent such studies. On the other hand, in vitro studies have proven to be useful for answering long-standing questions. Although technically still demanding, long-term single-cell imagin

APA, Harvard, Vancouver, ISO, and other styles

11

Hoffren, Anna-Marja, Liisa Holm, Leif Laaksonen, Tuula Teeri, and Olle Teleman. "Molecular dynamics simulations of hapten binding to structural models of 2-phenyloxazolone antibodies." ImmunoMethods 1, no. 2 (1992): 80–90. http://dx.doi.org/10.1016/s1058-6687(05)80031-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Ikeguchi, Mitsunori. "Water transport in aquaporins: molecular dynamics simulations." Frontiers in Bioscience Volume, no. 14 (2009): 1283. http://dx.doi.org/10.2741/3308.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Sharma, Shantanu. "Probing protein aggregation using discrete molecular dynamics." Frontiers in Bioscience Volume, no. 13 (2008): 4795. http://dx.doi.org/10.2741/3039.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Davis, Patricia L., Edward C. Holmes, Florence Larrous, et al. "Phylogeography, Population Dynamics, and Molecular Evolution of European Bat Lyssaviruses." Journal of Virology 79, no. 16 (2005): 10487–97. http://dx.doi.org/10.1128/jvi.79.16.10487-10497.2005.

Full text

Abstract:

ABSTRACT European bat lyssaviruses types 1 and 2 (EBLV-1 and EBLV-2) are widespread in Europe, although little is known of their evolutionary history. We undertook a comprehensive sequence analysis to infer the selection pressures, rates of nucleotide substitution, age of genetic diversity, geographical origin, and population growth rates of EBLV-1. Our study encompassed data from 12 countries collected over a time span of 35 years and focused on the glycoprotein (G) and nucleoprotein (N) genes. We show that although the two subtypes of EBLV-1—EBLV-1a and EBLV-1b—have both grown at a low expon

APA, Harvard, Vancouver, ISO, and other styles

15

Ribarics, Reiner, Rudolf Karch, Nevena Ilieva та Wolfgang Schreiner. "Geometric Analysis of Alloreactive HLAα-Helices". BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/943186.

Full text

Abstract:

Molecular dynamics (MD) is a valuable tool for the investigation of functional elements in biomolecules, providing information on dynamic properties and processes. Previous work by our group has characterized static geometric properties of the two MHCα-helices comprising the peptide binding region recognized by T cells. We build upon this work and used several spline models to approximate the overall shape of MHCα-helices. We applied this technique to a series of MD simulations of alloreactive MHC molecules that allowed us to capture the dynamics of MHCα-helices’ steric configurations. Here, w

APA, Harvard, Vancouver, ISO, and other styles

16

Coller, Kelly E., Nicholas S. Heaton, Kristi L. Berger, Jacob D. Cooper, Jessica L. Saunders, and Glenn Randall. "Molecular Determinants and Dynamics of Hepatitis C Virus Secretion." PLoS Pathogens 8, no. 1 (2012): e1002466. http://dx.doi.org/10.1371/journal.ppat.1002466.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Belay, Tesfaye, Francis O. Eko, Godwin A. Ananaba, et al. "Chemokine and Chemokine Receptor Dynamics during Genital Chlamydial Infection." Infection and Immunity 70, no. 2 (2002): 844–50. http://dx.doi.org/10.1128/iai.70.2.844-850.2002.

Full text

Abstract:

ABSTRACT Current design strategies for vaccines against certain microbial pathogens, including Chlamydia trachomatis, require the induction and targeting of specific immune effectors to the local sites of infection known as the mucosal effector sites. Chemokines and their receptors are important mediators of leukocyte trafficking and of the controlled recruitment of specific leukocyte clonotypes during host defense against infections and during inflammation. We analyzed the dynamics of chemokine and chemokine receptor expression in genital mucosae during genital chlamydial infection in a murin

APA, Harvard, Vancouver, ISO, and other styles

18

Archontis, Georgios, Phanourios Tamamis, Spiros S. Skourtis, Dimitrios Morikis, and John D. Lambris. "Conformational analysis of compstatin analogues with molecular dynamics simulations in explicit water." Molecular Immunology 44, no. 1-3 (2007): 150. http://dx.doi.org/10.1016/j.molimm.2006.07.013.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Mackey, Michael C., Marta Tyran-Kamińska, and Romain Yvinec. "Molecular distributions in gene regulatory dynamics." Journal of Theoretical Biology 274, no. 1 (2011): 84–96. http://dx.doi.org/10.1016/j.jtbi.2011.01.020.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Schroeder, Timm. "Long-term Live Single Cell Quantification of Transcription Factor Dynamics." Blood 128, no. 22 (2016): SCI—4—SCI—4. http://dx.doi.org/10.1182/blood.v128.22.sci-4.sci-4.

Full text

Abstract:

Abstract Hematopoiesis is highly complex and dynamic, and consist of large numbers of different cells expressing many molecules. Despite intensive research, many long-standing questions in hematopoiesis research remain disputed. One major reason is the fact that we usually only analyze populations of cells - rather than individual cells - at very few time points of an experiment. Tracking of individual cells would be an extremely powerful approach to improve our understanding of molecular cell fate control. We are therefore developing imaging systems to follow the fate of single cells over man

APA, Harvard, Vancouver, ISO, and other styles

21

Cung, M. T., P. Demange, M. Marraud, et al. "Anti-AChR monoclonal antibody-peptide interactions studied by 2D-NMR spectroscopy and molecular dynamics analysis." Journal of Autoimmunity 4, no. 6 (1991): xi. http://dx.doi.org/10.1016/0896-8411(91)90078-q.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Richard, Guy-Franck, Alix Kerrest, and Bernard Dujon. "Comparative Genomics and Molecular Dynamics of DNA Repeats in Eukaryotes." Microbiology and Molecular Biology Reviews 72, no. 4 (2008): 686–727. http://dx.doi.org/10.1128/mmbr.00011-08.

Full text

Abstract:

SUMMARY Repeated elements can be widely abundant in eukaryotic genomes, composing more than 50% of the human genome, for example. It is possible to classify repeated sequences into two large families, “tandem repeats” and “dispersed repeats.” Each of these two families can be itself divided into subfamilies. Dispersed repeats contain transposons, tRNA genes, and gene paralogues, whereas tandem repeats contain gene tandems, ribosomal DNA repeat arrays, and satellite DNA, itself subdivided into satellites, minisatellites, and microsatellites. Remarkably, the molecular mechanisms that create and

APA, Harvard, Vancouver, ISO, and other styles

23

Zuo, Zhili, Oi Wah Liew, Gang Chen, et al. "Mechanism of NS2B-Mediated Activation of NS3pro in Dengue Virus: Molecular Dynamics Simulations and Bioassays." Journal of Virology 83, no. 2 (2008): 1060–70. http://dx.doi.org/10.1128/jvi.01325-08.

Full text

Abstract:

ABSTRACT The NS2B cofactor is critical for proteolytic activation of the flavivirus NS3 protease. To elucidate the mechanism involved in NS2B-mediated activation of NS3 protease, molecular dynamic simulation, principal component analysis, molecular docking, mutagenesis, and bioassay studies were carried out on both the dengue virus NS3pro and NS2B-NS3pro systems. The results revealed that the NS2B-NS3pro complex is more rigid than NS3pro alone due to its robust hydrogen bond and hydrophobic interaction networks within the complex. These potent networks lead to remodeling of the secondary and t

APA, Harvard, Vancouver, ISO, and other styles

24

Buzón, Maria J., Francisco M. Codoñer, Simon D. W. Frost, et al. "Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART." PLoS Pathogens 7, no. 10 (2011): e1002314. http://dx.doi.org/10.1371/journal.ppat.1002314.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Orban, Tivadar, and Michael Kalafatis. "Human Coagulation Factor Va Interaction with Phospholipid Vesicles: A Molecular Dynamics Study." Blood 108, no. 11 (2006): 1699. http://dx.doi.org/10.1182/blood.v108.11.1699.1699.

Full text

Abstract:

Abstract The prothrombinase complex, the enzyme responsible for the timely conversion of prothrombin to thrombin, is composed of factor Xa (the enzyme), factor Va (the cofactor) assembled on the activated cell surface in the presence of divalent metal ions. In our quest to propose a model of the prothrombinase complex we first created a homology model in solution of factor Va (pdb code 1y61). Next we created a mixed phospholipid bilayer model composed of 1-palmitoyl, 2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) and 1-palmitoyl, 2-oleoyl-sn-glycero-3-phosphatidylserine (POPS) in a 4:1 ratio

APA, Harvard, Vancouver, ISO, and other styles

26

Invergo, Brandon M., Ludovica Montanucci, and Jaume Bertranpetit. "Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins." Proceedings of the Royal Society B: Biological Sciences 282, no. 1820 (2015): 20152215. http://dx.doi.org/10.1098/rspb.2015.2215.

Full text

Abstract:

Determining the influence of complex, molecular-system dynamics on the evolution of proteins is hindered by the significant challenge of quantifying the control exerted by the proteins on system output. We have employed a combination of systems biology and molecular evolution analyses in a first attempt to unravel this relationship. We employed a comprehensive mathematical model of mammalian phototransduction to predict the degree of influence that each protein in the system exerts on the high-level dynamic behaviour. We found that the genes encoding the most dynamically sensitive proteins exh

APA, Harvard, Vancouver, ISO, and other styles

27

Zhu, Jieqing, Jianghai Zhu, Ana Negri та ін. "Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening". Blood 116, № 23 (2010): 5050–59. http://dx.doi.org/10.1182/blood-2010-04-281154.

Full text

Abstract:

Abstract The platelet integrin αIIbβ3 is essential for hemostasis and thrombosis through its binding of adhesive plasma proteins. We have determined crystal structures of the αIIbβ3 headpiece in the absence of ligand and after soaking in RUC-1, a novel small molecule antagonist. In the absence of ligand, the αIIbβ3 headpiece is in a closed conformation, distinct from the open conformation visualized in presence of Arg-Gly-Asp (RGD) antagonists. In contrast to RGD antagonists, RUC-1 binds only to the αIIb subunit. Molecular dynamics revealed nearly identical binding. Two species-specific residu

APA, Harvard, Vancouver, ISO, and other styles

28

Chela-Flores, Julian. "Towards the molecular bases of polymerase dynamics." Journal of Theoretical Biology 154, no. 4 (1992): 519–39. http://dx.doi.org/10.1016/s0022-5193(05)80167-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Carrasco, Yolanda R. "Molecular cues involved in the regulation of B cell dynamics: Assistants of antigen hunting." Journal of Leukocyte Biology 107, no. 6 (2020): 1107–13. http://dx.doi.org/10.1002/jlb.1mr0220-276r.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

DiNatale, Renzo G., A. Ari Hakimi, and Timothy A. Chan. "Genomics-based immuno-oncology: bridging the gap between immunology and tumor biology." Human Molecular Genetics 29, R2 (2020): R214—R225. http://dx.doi.org/10.1093/hmg/ddaa203.

Full text

Abstract:

Abstract The first hypotheses about how the immune system affects cancers were proposed in the early 20th century. These early concepts about cancer immunosurveillance were further developed in the decades that followed, but a detailed understanding of cancer immunity remained elusive. It was only recently, through the advent of high-throughput technologies, that scientists gained the ability to profile tumors with a resolution that allowed for granular assessment of both tumor cells and the tumor microenvironment. The advent of immune checkpoint inhibitors (ICIs), which have proven to be effe

APA, Harvard, Vancouver, ISO, and other styles

31

Jenwitheesuk, Ekachai, and Ram Samudrala. "Virtual screening of HIV-1 protease inhibitors against human cytomegalovirus protease using docking and molecular dynamics." AIDS 19, no. 5 (2005): 529–31. http://dx.doi.org/10.1097/01.aids.0000162343.96674.4c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Li, Na, Simei Qiu, Ying Fang, Jianhua Wu та Quhuan Li. "Comparison of Linear vs. Cyclic RGD Pentapeptide Interactions with Integrin αvβ3 by Molecular Dynamics Simulations". Biology 10, № 7 (2021): 688. http://dx.doi.org/10.3390/biology10070688.

Full text

Abstract:

Integrin αvβ3 interacting with the short Arg-Gly-Asp (RGD) motif plays a critical role in the progression of several types of tumors. However, the effects of the RGD structure (cyclic or linear) with integrin αvβ3 at the atomic level remain poorly understood. Here, we performed association and dissociation dynamic simulations for integrin αvβ3 in complex with a linear or cyclic pentapeptide by steered molecular dynamics simulations. Compared with cyclic RGD, the linear RGD peptide triggers instability of the configurational changes, mainly resting with the RGD domain due to its flexibility. Th

APA, Harvard, Vancouver, ISO, and other styles

33

Chen, Hui-Chen, and Nancy C. Reich. "11 Nuclear transport dynamics of STAT6." Cytokine 43, no. 3 (2008): 239. http://dx.doi.org/10.1016/j.cyto.2008.07.051.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Bagnarelli, P., A. Valenza, S. Menzo, et al. "Dynamics of molecular parameters of human immunodeficiency virus type 1 activity in vivo." Journal of Virology 68, no. 4 (1994): 2495–502. http://dx.doi.org/10.1128/jvi.68.4.2495-2502.1994.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Salem, Rana, Radwan Massoud, Rami Mahfouz, Ali Bazarbachi, and Jean El Cheikh. "Dynamics of Molecular Response in AML Patients with NPM1 and FLT3 Mutations Undergoing Allogeneic Stem Cell Transplant." Blood 128, no. 22 (2016): 5238. http://dx.doi.org/10.1182/blood.v128.22.5238.5238.

Full text

Abstract:

Abstract BACKGROUND: Concomitant NPM1 and FLT3 mutation occurs in 20% of AML patients. Molecular response and achievement of negative minimal residual disease (MRD) are strong predictors of long-term outcome. However, little is known about the dynamics of molecular response in NPM-1 and FLT-3 double positive mutations. OBJECTIVE: To assess the dynamics of molecular response to treatment in AML adult patients with concomitant FLT3 and NPM1 mutations. DESIGN: Retrospective single center study. SETTING: This study was approved by the institutional review board of American University of Beirut Med

APA, Harvard, Vancouver, ISO, and other styles

36

Moroni, Elisabetta. "Structure and sequence determinants of aggregation investigated with molecular dynamics." Frontiers in Bioscience Volume, no. 14 (2009): 523. http://dx.doi.org/10.2741/3260.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Wei, Guanghong. "Self-assembly of amyloid-forming peptides by molecular dynamics simulations." Frontiers in Bioscience Volume, no. 13 (2008): 5681. http://dx.doi.org/10.2741/3109.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Suda, Hitoshi, and Minoru Saito. "Molecular Dynamics Simulations for Actin Monomers in Solution." Journal of Theoretical Biology 171, no. 3 (1994): 347–49. http://dx.doi.org/10.1006/jtbi.1994.1237.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Essadssi, Soukaina, Al Mehdi Krami, Lamiae Elkhattabi, et al. "Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation." Journal of Immunology Research 2019 (November 3, 2019): 1–14. http://dx.doi.org/10.1155/2019/5902391.

Full text

Abstract:

Severe combined immunodeficiency (SCID) is the most severe form of primary immunodeficiency (PID), characterized by fatal opportunistic infections. The ADA gene encodes adenosine deaminase, an enzyme that catalyzes the irreversible deamination of adenosine and deoxyadenosine in the catabolic pathway of purine. Mutations of the ADA gene have been identified in patients with severe combined immunodeficiency. In this study, we performed a bioinformatics analysis of the human ADA gene to identify potentially harmful nonsynonymous SNPs and their effect on protein structure and stability. Using elev

APA, Harvard, Vancouver, ISO, and other styles

40

Barisas, B. George, William F. Wade, Thomas M. Jovin, Donna Arndt-Jovin, and Deborah A. Roess. "Dynamics of molecules involved in antigen presentation: effects of fixation." Molecular Immunology 36, no. 11-12 (1999): 701–8. http://dx.doi.org/10.1016/s0161-5890(99)00091-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Hu, Wei, Chenyi An, and Wei J. Chen. "Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions." BioMed Research International 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/486827.

Full text

Abstract:

Neural synapses are intercellular asymmetrical junctions that transmit biochemical and biophysical information between a neuron and a target cell. They are very tight, dynamic, and well organized by many synaptic adhesion molecules, signaling receptors, ion channels, and their associated cytoskeleton that bear forces. Mechanical forces have been an emerging factor in regulating axon guidance and growth, synapse formation and plasticity in physiological and pathological brain activity. Therefore, mechanical forces are undoubtedly exerted on those synaptic molecules and modulate their functions.

APA, Harvard, Vancouver, ISO, and other styles

42

Pollitt, Eric J. G., Piotr T. Szkuta, Nicola Burns, and Simon J. Foster. "Staphylococcus aureus infection dynamics." PLOS Pathogens 14, no. 6 (2018): e1007112. http://dx.doi.org/10.1371/journal.ppat.1007112.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Gillinder, Kevin R., Jim R. Hughes, Michael R. Tallack, et al. "Dynamics and Mechanics Of KLF1 Regulation In Erythropoiesis." Blood 122, no. 21 (2013): 2176. http://dx.doi.org/10.1182/blood.v122.21.2176.2176.

Full text

Abstract:

Abstract Krûppel-like factor-1 (KLF1) is a C2H2 zinc finger transcription factor which is essential for broad erythroid gene expression and erythropoiesis in vivo. A number of studies have shown ∼700 genes are poorly expressed when KLF1 is absent [1-8]. This global loss of expression is responsible for failure of effective red blood cell production in KLF1 knockout mice [9,10], and partly responsible for congenital anemia in humans and mice with dominant mutations in KLF1 [11,12]. To determine whether KLF1-dependent genes are direct or indirect targets of KLF1, we have previously performed glo

APA, Harvard, Vancouver, ISO, and other styles

44

Litvinov, Rustem I., Dzhigangir A. Faizullin, Yuriy F. Zuev, et al. "Molecular Basis of Biomechanics of Hemostasis and Thrombosis: Structural Molecular Transitions Underlying Deformation of Fibrin Clots and Thrombi." Blood 120, no. 21 (2012): 2217. http://dx.doi.org/10.1182/blood.v120.21.2217.2217.

Full text

Abstract:

Abstract Abstract 2217 A new field of biomedical research, biomechanics of hemostasis and thrombosis, has been quickly developing over the past few years. The mechanical properties of fibrin are essential in vivo for the ability of clots to stop bleeding in flowing blood but also determine the likelihood of obstructive thrombi that cause heart attack and stroke. Despite such critical importance, the structural basis of clot mechanics is not well understood. The structural changes underlying deformation of fibrin polymer occur at different spatial scales from macroscopic to submolecular, includ

APA, Harvard, Vancouver, ISO, and other styles

45

Lee, Tai-Sung, Steven Potts, Hagop Kantarjian, Jorge Cortes, Francis Giles, and Maher Albitar. "Molecular Basis Explanation of Imatinib Resistance of Bcr-Abl Due to T315I and P-Loop Mutations from Molecular Dynamics Simulations." Blood 110, no. 11 (2007): 2917. http://dx.doi.org/10.1182/blood.v110.11.2917.2917.

Full text

Abstract:

Abstract Molecular dynamics (MD) simulations on the complex of imatinib with the wild-type, T315I, and other 10 P-loop mutants of the tyrosine kinase Bcr-Abl have been performed to study the imatinib resistance mechanism at the atomic level. MD simulations show that large scale computational simulations could offer insight information that a static structure or simple homology modeling methods cannot provide for studying the Bcr-Abl imatinib resistance problem, especially in the case of conformational changes due to remote mutations. By utilizing the Molecular Mechanics/Poisson-Boltzmann surfa

APA, Harvard, Vancouver, ISO, and other styles

46

Bhattacharyya, Srirupa, та Siddhartha Sankar Ghosh. "Unfolding transmembrane TNFα dynamics in cancer therapeutics". Cytokine 137 (січень 2021): 155303. http://dx.doi.org/10.1016/j.cyto.2020.155303.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Cimica, Velasco, Janaki Iyer, and Nancy C. Reich. "Cellular dynamics of the STAT3 transcription factor." Cytokine 48, no. 1-2 (2009): 127. http://dx.doi.org/10.1016/j.cyto.2009.07.538.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Varona, Pablo, and Mikhail I. Rabinovich. "Hierarchical dynamics of informational patterns and decision-making." Proceedings of the Royal Society B: Biological Sciences 283, no. 1832 (2016): 20160475. http://dx.doi.org/10.1098/rspb.2016.0475.

Full text

Abstract:

Traditional studies on the interaction of cognitive functions in healthy and disordered brains have used the analyses of the connectivity of several specialized brain networks—the functional connectome. However, emerging evidence suggests that both brain networks and functional spontaneous brain-wide network communication are intrinsically dynamic. In the light of studies investigating the cooperation between different cognitive functions, we consider here the dynamics of hierarchical networks in cognitive space. We show, using an example of behavioural decision-making based on sequential epis

APA, Harvard, Vancouver, ISO, and other styles

49

Guerrero, Estefania Garcia, Irene Diaz Moreno, Miguel Angel De la rosa, Jose Antonio Pérez Simón, and Antonio Diaz Quintana. "Molecular Dynamics As a Computational Tool To Analyze Lymphocyte Alloreactivity In Hematopoietic Transplant Recipients." Blood 122, no. 21 (2013): 1049. http://dx.doi.org/10.1182/blood.v122.21.1049.1049.

Full text

Abstract:

Abstract Introduction The generation of the immune response requires the recognition of peptides presented by the major histocompatibility complex (MHC) through the T cell receptor (TCR). In the hematopoietic transplantation context, T cells (LT) from the donor recognize foreign MHC or own MHC bound to foreign peptides (pMHC), generating an alloimmune response. Currently, the molecular mechanisms of LT alloimmune activation are unknown. In order to analyze the molecular interactions between peptides, MHC and TCR, we have implemented Molecular Dynamics techniques. We have compared immunological

APA, Harvard, Vancouver, ISO, and other styles

50

Jelsbak, Lars, Helle Krogh Johansen, Anne-Louise Frost, et al. "Molecular Epidemiology and Dynamics of Pseudomonas aeruginosa Populations in Lungs of Cystic Fibrosis Patients." Infection and Immunity 75, no. 5 (2007): 2214–24. http://dx.doi.org/10.1128/iai.01282-06.

Full text

Abstract:

ABSTRACT The ability to establish lifelong persistent infections is a fundamental aspect of the interactions between many pathogenic microorganisms and their mammalian hosts. One example is chronic lung infections by the opportunistic pathogen Pseudomonas aeruginosa in cystic fibrosis (CF) patients. This infection process is associated with extensive genetic adaptation and microevolution of the infecting bacteria. Through investigations of P. aeruginosa populations and infection dynamics in a group of CF patients followed at the Danish CF Clinic in Copenhagen, we have identified two distinct a

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!