Relevant bibliographies by topics / Immunomodulatory activity, Apoptosis

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Immunomodulatory activity, Apoptosis'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "Immunomodulatory activity, Apoptosis"

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Staniszewska, Justyna, Marcin Szymański, and Ewa Ignatowicz. "Antitumor and immunomodulatory activity of Inonotus obliquus." Herba Polonica 63, no. 2 (2017): 48–58. http://dx.doi.org/10.1515/hepo-2017-0013.

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SummaryThe article presents the antitumor and immunomodulatory activity of compounds and extracts fromInonotus obliquus.Polysaccharides isolated from sclerotium have a direct antitumor effect due to protein synthesis inhibition in tumor cells. Polysaccharides derived from the mycelium function by activating the immune system. Due to the limited toxicity of these substances, both extracts as well as isolated and purified chemicals may be a good alternative to current chemotherapy and play a role in cancer prevention.In vitroexperiments have shown the inhibition of inflammation with the influenc
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Chilczuk, Tomasz, Carmen Steinborn, Steffen Breinlinger, et al. "Hapalindoles from the Cyanobacterium Hapalosiphon sp. Inhibit T Cell Proliferation." Planta Medica 86, no. 02 (2019): 96–103. http://dx.doi.org/10.1055/a-1045-5178.

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AbstractNovel immunomodulating agents are currently sought after for the treatment of autoimmune diseases and cancers. In this context, a screening campaign of a collection of 575 cyanobacteria extracts for immunomodulatory effects has been conducted. The screening resulted in several active extracts. Here we report the results of subsequent studies on an extract from the cyanobacterium Hapalosiphon sp. CBT1235. We identified 5 hapalindoles as the compounds responsible for the observed immunomodulatory effect. These indole alkaloids are produced by several strains of the cyanobacterial family
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Foroutan-Rad, Masoud, Khosrow Hazrati Tappeh, and Shahram Khademvatan. "Antileishmanial and Immunomodulatory Activity of Allium sativum (Garlic)." Journal of Evidence-Based Complementary & Alternative Medicine 22, no. 1 (2016): 141–55. http://dx.doi.org/10.1177/2156587215623126.

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Leishmaniasis is caused by an obligate intracellular protozoa belonging to Leishmania genus. The current drugs for treatment of leishmaniasis possess many disadvantages; therefore, researchers are continuously looking for the more effective and safer drugs. The aim of this study is to review the effectiveness, toxicities, and possible mechanisms of pharmaceutical actions of different garlic extracts and organosulfur compounds isolated from garlic against Leishmania spp. in a variety of in vitro, in vivo and clinical trials reports. All relevant databases were searched using the terms “ Allium
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Hagner, Patrick R., Hon-Wah Man, Celia Fontanillo, et al. "CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL." Blood 126, no. 6 (2015): 779–89. http://dx.doi.org/10.1182/blood-2015-02-628669.

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Key Points CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity. CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL.
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Amatangelo, Michael D., Chad C. Bjorklund, Anita K. Gandhi, et al. "IMiD® Immunomodulatory Agents Promote Apoptosis in Multiple Myeloma Cells through Induction of TRAIL Expression." Blood 126, no. 23 (2015): 5355. http://dx.doi.org/10.1182/blood.v126.23.5355.5355.

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Abstract Background: Immunomodulatory drugs exhibit several anti-Multiple Myeloma (MM) activities including: growth arrest, antiangiogenesis, inhibition of tumor necrosis factor-alpha signaling and induction of apoptosis. The mechanism of action of the IMiD® compounds lenalidomide and pomalidomide that are responsible for these effects are starting to become clear. IMiD® compounds directly bind Cereblon (CBRN), a substrate receptor of the cullin ring E3 ligase (CRL4), and induce CRL4CRBN -mediated degradation of the zinc finger transcriptional repressors Aiolos and Ikaros by ubiquitin-mediated
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Mitsiades, Nicholas, Constantine S. Mitsiades, Vassiliki Poulaki, et al. "Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications." Blood 99, no. 12 (2002): 4525–30. http://dx.doi.org/10.1182/blood.v99.12.4525.

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Thalidomide (Thal) achieves responses even in the setting of refractory multiple myeloma (MM). Although increased angiogenesis in MM bone marrow and the antiangiogenic effect of Thal formed the empiric basis for its use in MM, we have shown that Thal and its immunomodulatory analogs (IMiDs) directly induce apoptosis or growth arrest of MM cells, alter adhesion of MM cells to bone marrow stromal cells, inhibit the production of cytokines (interleukin-6 and vascular endothelial growth factor) in bone marrow, and stimulate natural killer cell anti-MM immunity. In the present study, we demonstrate
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Munemasa, Shoso, Akira Sakai, Yoshiaki Kuroda, et al. "Immunomodulatory Thalidomide Analogs Do Not Affect Osteoprogenitor Differentiation and Low Concentration of Bortezomib Promotes It, While Both Agents Suppress Osteoclast Differentiation." Blood 110, no. 11 (2007): 4780. http://dx.doi.org/10.1182/blood.v110.11.4780.4780.

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Abstract Bone disease (BD) is a frequent characteristic of multiple myeloma (MM) and leads to severe clinical complications. BD in MM is due to not only the activation of osteoclast but also the impairment of osteoblast differentiation. Treatment for MM using high-dose melphalan followed by tandem auto-stem cell transplantation (tandem ASCT) and new drugs such as bortezomib (PS-341), thalidomide, and lenalidomide have improved OS. Interestingly, some reports have shown high serum bone-specific alkaline phosphatase levels after bortezomib-combined therapy in MM patients, and administration of p
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8

Baffour Tonto, Prince, Taro Yasuma, Tetsu Kobayashi, et al. "Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis." International Journal of Molecular Sciences 20, no. 5 (2019): 1082. http://dx.doi.org/10.3390/ijms20051082.

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Acute lung injury is a fatal disease characterized by inflammatory cell infiltration, alveolar-capillary barrier disruption, protein-rich edema, and impairment of gas exchange. Protein S is a vitamin K-dependent glycoprotein that exerts anticoagulant, immunomodulatory, anti-inflammatory, anti-apoptotic, and neuroprotective effects. The aim of this study was to evaluate whether human protein S inhibits cell apoptosis in acute lung injury. Acute lung injury in human protein S transgenic and wild-type mice was induced by intratracheal instillation of lipopolysaccharide. The effect of human protei
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Cieślak, Marcin, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, et al. "New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities." Biomolecules 9, no. 9 (2019): 446. http://dx.doi.org/10.3390/biom9090446.

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We identified novel dicarboximides that were selectively cytotoxic towards human leukemia cells. Using chemical and biological methods, we characterized the biological activity, identified cellular protein targets and defined the mechanism of action of the test dicarboximides. The reported IC50 values (concentration required to reduce cell survival fraction to 50% of control) of selected dicarboximides were similar or lower than IC50 of registered anticancer drugs, for example cytarabine, sorafenib, irinotecan. Test compounds induced apoptosis in chronic myelogenous (K562) and acute lymphoblas
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Otta, Dayane Andriotti, Fernanda Fortes de Araújo, Vitor Bortolo de Rezende, et al. "Identification of Anti-Trypanosoma cruziLead Compounds with Putative Immunomodulatory Activity." Antimicrobial Agents and Chemotherapy 62, no. 4 (2018): e01834-17. http://dx.doi.org/10.1128/aac.01834-17.

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ABSTRACTIn seeking substitutions for the current Chagas disease treatment, which has several relevant side effects, new therapeutic candidates have been extensively investigated. In this context, a balanced interaction between mediators of the host immune response seems to be a key element for therapeutic success, as a proinflammatory microenvironment modulated by interleukin-10 (IL-10) is shown to be relevant to potentiate anti-Trypanosoma cruzidrug activity. This study aimed to identify the potential immunomodulatory activities of the anti-T. cruziK777, pyronaridine (PYR), and furazolidone (
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Dissertations / Theses on the topic "Immunomodulatory activity, Apoptosis"

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PEREIRA, Flávia de Castro. "Avaliação do Potencial Citotóxico, Genotóxico e Antitumoral do Ditionato de cis-Tetraamino(oxalato)rutênio(III) em Diferentes Linhagens Celulares." Universidade Federal de Goiás, 2010. http://repositorio.bc.ufg.br/tede/handle/tde/1288.

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Made available in DSpace on 2014-07-29T15:16:36Z (GMT). No. of bitstreams: 1 Dissertacao Flavia de Castro Pereira UFG 2010 - part 1.pdf: 495954 bytes, checksum: 284a68ffbde993ede09791444dec1865 (MD5) Previous issue date: 2010-01-22<br>Despite the resounding success of cisplatin and closely related platinum antitumor agents, the movement of other transition-metal antitumor agents toward the clinic has been exceptionally slow. Non-Platinum chemotherapeutic metallopharmaceuticals hold much promise for the future, and needs to be actively explored in a large variety of tumor types in combination
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Journal articles
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