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Journal articles on the topic 'Immunomodulatory activity, Apoptosis'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Staniszewska, Justyna, Marcin Szymański, and Ewa Ignatowicz. "Antitumor and immunomodulatory activity of Inonotus obliquus." Herba Polonica 63, no. 2 (2017): 48–58. http://dx.doi.org/10.1515/hepo-2017-0013.

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SummaryThe article presents the antitumor and immunomodulatory activity of compounds and extracts fromInonotus obliquus.Polysaccharides isolated from sclerotium have a direct antitumor effect due to protein synthesis inhibition in tumor cells. Polysaccharides derived from the mycelium function by activating the immune system. Due to the limited toxicity of these substances, both extracts as well as isolated and purified chemicals may be a good alternative to current chemotherapy and play a role in cancer prevention.In vitroexperiments have shown the inhibition of inflammation with the influenc

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Chilczuk, Tomasz, Carmen Steinborn, Steffen Breinlinger, et al. "Hapalindoles from the Cyanobacterium Hapalosiphon sp. Inhibit T Cell Proliferation." Planta Medica 86, no. 02 (2019): 96–103. http://dx.doi.org/10.1055/a-1045-5178.

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AbstractNovel immunomodulating agents are currently sought after for the treatment of autoimmune diseases and cancers. In this context, a screening campaign of a collection of 575 cyanobacteria extracts for immunomodulatory effects has been conducted. The screening resulted in several active extracts. Here we report the results of subsequent studies on an extract from the cyanobacterium Hapalosiphon sp. CBT1235. We identified 5 hapalindoles as the compounds responsible for the observed immunomodulatory effect. These indole alkaloids are produced by several strains of the cyanobacterial family

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Foroutan-Rad, Masoud, Khosrow Hazrati Tappeh, and Shahram Khademvatan. "Antileishmanial and Immunomodulatory Activity of Allium sativum (Garlic)." Journal of Evidence-Based Complementary & Alternative Medicine 22, no. 1 (2016): 141–55. http://dx.doi.org/10.1177/2156587215623126.

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Leishmaniasis is caused by an obligate intracellular protozoa belonging to Leishmania genus. The current drugs for treatment of leishmaniasis possess many disadvantages; therefore, researchers are continuously looking for the more effective and safer drugs. The aim of this study is to review the effectiveness, toxicities, and possible mechanisms of pharmaceutical actions of different garlic extracts and organosulfur compounds isolated from garlic against Leishmania spp. in a variety of in vitro, in vivo and clinical trials reports. All relevant databases were searched using the terms “ Allium

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Hagner, Patrick R., Hon-Wah Man, Celia Fontanillo, et al. "CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL." Blood 126, no. 6 (2015): 779–89. http://dx.doi.org/10.1182/blood-2015-02-628669.

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Key Points CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity. CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL.

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Amatangelo, Michael D., Chad C. Bjorklund, Anita K. Gandhi, et al. "IMiD® Immunomodulatory Agents Promote Apoptosis in Multiple Myeloma Cells through Induction of TRAIL Expression." Blood 126, no. 23 (2015): 5355. http://dx.doi.org/10.1182/blood.v126.23.5355.5355.

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Abstract Background: Immunomodulatory drugs exhibit several anti-Multiple Myeloma (MM) activities including: growth arrest, antiangiogenesis, inhibition of tumor necrosis factor-alpha signaling and induction of apoptosis. The mechanism of action of the IMiD® compounds lenalidomide and pomalidomide that are responsible for these effects are starting to become clear. IMiD® compounds directly bind Cereblon (CBRN), a substrate receptor of the cullin ring E3 ligase (CRL4), and induce CRL4CRBN -mediated degradation of the zinc finger transcriptional repressors Aiolos and Ikaros by ubiquitin-mediated

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Mitsiades, Nicholas, Constantine S. Mitsiades, Vassiliki Poulaki, et al. "Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications." Blood 99, no. 12 (2002): 4525–30. http://dx.doi.org/10.1182/blood.v99.12.4525.

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Thalidomide (Thal) achieves responses even in the setting of refractory multiple myeloma (MM). Although increased angiogenesis in MM bone marrow and the antiangiogenic effect of Thal formed the empiric basis for its use in MM, we have shown that Thal and its immunomodulatory analogs (IMiDs) directly induce apoptosis or growth arrest of MM cells, alter adhesion of MM cells to bone marrow stromal cells, inhibit the production of cytokines (interleukin-6 and vascular endothelial growth factor) in bone marrow, and stimulate natural killer cell anti-MM immunity. In the present study, we demonstrate

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Munemasa, Shoso, Akira Sakai, Yoshiaki Kuroda, et al. "Immunomodulatory Thalidomide Analogs Do Not Affect Osteoprogenitor Differentiation and Low Concentration of Bortezomib Promotes It, While Both Agents Suppress Osteoclast Differentiation." Blood 110, no. 11 (2007): 4780. http://dx.doi.org/10.1182/blood.v110.11.4780.4780.

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Abstract Bone disease (BD) is a frequent characteristic of multiple myeloma (MM) and leads to severe clinical complications. BD in MM is due to not only the activation of osteoclast but also the impairment of osteoblast differentiation. Treatment for MM using high-dose melphalan followed by tandem auto-stem cell transplantation (tandem ASCT) and new drugs such as bortezomib (PS-341), thalidomide, and lenalidomide have improved OS. Interestingly, some reports have shown high serum bone-specific alkaline phosphatase levels after bortezomib-combined therapy in MM patients, and administration of p

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Baffour Tonto, Prince, Taro Yasuma, Tetsu Kobayashi, et al. "Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis." International Journal of Molecular Sciences 20, no. 5 (2019): 1082. http://dx.doi.org/10.3390/ijms20051082.

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Acute lung injury is a fatal disease characterized by inflammatory cell infiltration, alveolar-capillary barrier disruption, protein-rich edema, and impairment of gas exchange. Protein S is a vitamin K-dependent glycoprotein that exerts anticoagulant, immunomodulatory, anti-inflammatory, anti-apoptotic, and neuroprotective effects. The aim of this study was to evaluate whether human protein S inhibits cell apoptosis in acute lung injury. Acute lung injury in human protein S transgenic and wild-type mice was induced by intratracheal instillation of lipopolysaccharide. The effect of human protei

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Cieślak, Marcin, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, et al. "New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities." Biomolecules 9, no. 9 (2019): 446. http://dx.doi.org/10.3390/biom9090446.

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We identified novel dicarboximides that were selectively cytotoxic towards human leukemia cells. Using chemical and biological methods, we characterized the biological activity, identified cellular protein targets and defined the mechanism of action of the test dicarboximides. The reported IC50 values (concentration required to reduce cell survival fraction to 50% of control) of selected dicarboximides were similar or lower than IC50 of registered anticancer drugs, for example cytarabine, sorafenib, irinotecan. Test compounds induced apoptosis in chronic myelogenous (K562) and acute lymphoblas

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Otta, Dayane Andriotti, Fernanda Fortes de Araújo, Vitor Bortolo de Rezende, et al. "Identification of Anti-Trypanosoma cruziLead Compounds with Putative Immunomodulatory Activity." Antimicrobial Agents and Chemotherapy 62, no. 4 (2018): e01834-17. http://dx.doi.org/10.1128/aac.01834-17.

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ABSTRACTIn seeking substitutions for the current Chagas disease treatment, which has several relevant side effects, new therapeutic candidates have been extensively investigated. In this context, a balanced interaction between mediators of the host immune response seems to be a key element for therapeutic success, as a proinflammatory microenvironment modulated by interleukin-10 (IL-10) is shown to be relevant to potentiate anti-Trypanosoma cruzidrug activity. This study aimed to identify the potential immunomodulatory activities of the anti-T. cruziK777, pyronaridine (PYR), and furazolidone (

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Miranda-Hernández, Mariana P., Carlos A. López-Morales, Nancy D. Ramírez-Ibáñez, et al. "Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity." Journal of Immunology Research 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/910763.

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Rituximab is a chimeric monoclonal antibody employed for the treatment of CD20-positive B-cell non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis and microscopic polyangiitis. It binds specifically to the CD20 antigen expressed on pre-B and consequently on mature B-lymphocytes of both normal and malignant cells, inhibiting their proliferation through apoptosis, CDC, and ADCC mechanisms. The immunomodulatory activity of rituximab is closely related to critical quality attributes that characterize its chemical composition and spatial conf

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Ghițu, Alexandra, Anja Schwiebs, Heinfried H. Radeke, et al. "A Comprehensive Assessment of Apigenin as an Antiproliferative, Proapoptotic, Antiangiogenic and Immunomodulatory Phytocompound." Nutrients 11, no. 4 (2019): 858. http://dx.doi.org/10.3390/nu11040858.

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Apigenin (4′,5,7-trihydroxyflavone) (Api) is an important component of the human diet, being distributed in a wide number of fruits, vegetables and herbs with the most important sources being represented by chamomile, celery, celeriac and parsley. This study was designed for a comprehensive evaluation of Api as an antiproliferative, proapoptotic, antiangiogenic and immunomodulatory phytocompound. In the set experimental conditions, Api presents antiproliferative activity against the A375 human melanoma cell line, a G2/M arrest of the cell cycle and cytotoxic events as revealed by the lactate d

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Cooney, Jeffrey D., and Ricardo C. T. Aguiar. "Phosphodiesterase 4 inhibitors have wide-ranging activity in B-cell malignancies." Blood 128, no. 25 (2016): 2886–90. http://dx.doi.org/10.1182/blood-2016-09-737676.

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Abstract Phosphodiesterase 4 (PDE4) inhibition restores the suppressive effects of 3′,5′-cyclic adenosine monophosphate in lymphocytes. In this concise review, we detail how PDE4 inhibition downmodulates the B-cell receptor (BCR)-related kinases spleen tyrosine kinase and phosphatidylinositol 3-kinase and inhibits vascular endothelial growth factor A secretion by tumor cells, inducing cancer cell apoptosis and blocking angiogenesis in the microenvironment. We describe the successful clinical repurposing of PDE4 inhibitors in B-cell malignancies, and propose that given their anti-inflammatory/i

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Szliszka, Ewelina, Anna Sokół-Łętowska, Alicja Z. Kucharska, Dagmara Jaworska, Zenon P. Czuba, and Wojciech Król. "Ethanolic Extract of Polish Propolis: Chemical Composition and TRAIL-R2 Death Receptor Targeting Apoptotic Activity against Prostate Cancer Cells." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/757628.

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Propolis possesses chemopreventive properties through direct anticancer and indirect immunomodulatory activities. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a significant role in immunosurveillance and defense against cancer cells. TRAIL triggers apoptosis upon binding to TRAIL-R1 (DR4) and TRAIL-R2 (DR5) death receptors expressed on cancer cell surface. The activation of TRAIL apoptotic signaling is considered an attractive option for cancer prevention. However, as more tumor cells are reported to be resistant to TRAIL-mediated death, it is important to develop new

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Kello, Martin, Peter Takac, Peter Kubatka, Tomas Kuruc, Klaudia Petrova, and Jan Mojzis. "Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells." Biomolecules 10, no. 1 (2020): 139. http://dx.doi.org/10.3390/biom10010139.

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In recent decades, several spices have been studied for their potential in the prevention and treatment of cancer. It is documented that spices have antioxidant, anti-inflammatory, immunomodulatory, and anticancer effects. The main mechanisms of spices action included apoptosis induction, proliferation, migration and invasion of tumour inhibition, and sensitization of tumours to radiotherapy and chemotherapy. In this study, the ability of clove buds extract (CBE) to induce oxidative stress, DNA damage, and stress/survival/apoptotic pathways modulation were analysed in MCF-7 cells. We demonstra

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Mehrotra, S., G. Agnihotri, S. Singh, and F. Jamal. "Immunomodulatory potential of Curcuma longa: A review." South Asian Journal of Experimental Biology 3, no. 6 (2014): 299–307. http://dx.doi.org/10.38150/sajeb.3(6).p299-307.

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Medicinal plants having immunomodulatory properties provide an alterna-tive potential to conventional chemotherapy for a variety of diseases espe-cially in relation to host defense mechanism. Curcumin one of major curcu-minoids of Curcuma longa, reportedly possess several pharmacological prop-erties including anti-inflammatory, anti-cancer, immunomodulatory activi-ties. Curcumin blocks inflammatory enzymes cyclooxygenase (COX), lipooxy-genase (LOX), matrix metalloproteinase (MMP). Curcumin suppresses the proliferation of a wide variety of tumour cells, including breast carcinoma, colon carcino

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Xue, Qun, Zhou Yin, Nagam Varshithreddy, et al. "The immunomodulatory function of human amniotic fluid stromal cells on B lymphocytes." Journal of Neurorestoratology 1, no. 1 (2018): 122–33. http://dx.doi.org/10.26599/jnr.2018.9040010.

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Current treatments for B cell-mediated disease are mainly based on global B cell depletion, thereby eliminating pathogenic B cells as well as Breg subsets. A more refined modulation of B cell activity could prove beneficial for patient treatment.Objective:To investigate the immunomodulatory function of human amniotic fluid stromal cells (hAFSCs) on different subpopulation of B lymphocytes.Methods:hAFSCs were isolated and cultured and identified by characteristic phenotypic markers. After coculture of B lymphocytes with hAFSCs, the activation, proliferation, differentiation, as well as apoptosi

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Vacaru, Ana-Maria, Madalina Dumitrescu, Andrei Mircea Vacaru, et al. "Enhanced Suppression of Immune Cells In Vitro by MSC Overexpressing FasL." International Journal of Molecular Sciences 22, no. 1 (2020): 348. http://dx.doi.org/10.3390/ijms22010348.

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Mesenchymal stromal cells (MSC) display several mechanisms of action that may be harnessed for therapeutic purposes. One of their most attractive features is their immunomodulatory activity that has been extensively characterized both in vitro and in vivo. While this activity has proven to be very efficient, it is transient. We aimed to enhance it by transforming MSC to overexpress a first apoptosis signal (Fas) ligand (FasL). In this study, our goal was to induce FasL overexpression through adenoviral transduction in MSC to improve their immunomodulatory activity. We characterized the impact

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Kozhevnikova, T. N., A. V. Sanin, and S. V. Ozherelkov. "ANTIAPOPTOSIS ACTIVITY OF PLANT POLYPRENYLPHOSPHATE AGAINST MACROPHAGE TARGET CELLS INFECTED WITH THE MURINE ENCEPHALOMYELITIS VIRUS." Medical academic journal 19, no. 1S (2019): 207–9. http://dx.doi.org/10.17816/maj191s1207-209.

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Antiapoptosis activity of plant polyprenylphosphate against macrophage target cells infected with the murine encephalomyelitis virus. Infection caused by the Theiler’s murine encephalomyelitis virus (TMEV) is regarded as an experimental model of multiple sclerosis, since both of these diseases are characterized by similar pathology of the central nervous system tissues and involvement of the immune system in the development of the demielinization. The aim of the work was to study the effect of plant-derived polyprenylphosphate (PP) on the apoptosis of infected target cells. We showed that PP r

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Singh, Nand K., Saty B. Singh, and Anuraag Shrivastav. "Antitumour and Immunomodulatory Effects of Cu(II) Complexes of Thiobenzyhdrazide." Metal-Based Drugs 9, no. 1-2 (2002): 109–18. http://dx.doi.org/10.1155/mbd.2002.109.

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Thiiobenzyhdrazide (Htbh) and its Cu(II) complexes, [Cu(Htbh)2Cl2] and [Cu(tbh)2] were synthesized and characterized by various physicochemical studies. In vivo and in vitro antitumour activity of Htbh, [Cu(Htbh)2Cl2] and [Cu(tbh)2] has been tested. LD50 values were calculated for all the three compounds. It was observed that the antitumour effect of [Cu(Htbh)2Cl2] is maximum. Light microscopic study of the treated tumour mass demonstrated that certain cellular degradation, such as disappearance of mitotic figures, loss in cellular compactness, distortion of nucleus and disruption of cytoplasm

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Andreicuț, Andra Diana, Eva Fischer-Fodor, Alina Elena Pârvu, et al. "Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts." Oxidative Medicine and Cellular Longevity 2019 (December 16, 2019): 1–13. http://dx.doi.org/10.1155/2019/6439021.

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The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems in vitro and in vivo. Whereas the antioxidative and antitumor activities of M. aquifolium-derived compounds were studied at some extent, there are very few data about their outcome on the immune system and tumor cells. To elucidate the M. aquifolium potential immunomodulatory and antiproliferative effects, the bark, leaf, flower, green fruit, and ripe

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Wang, Jing-Jing, Yan Wang, Lizhen Hou, et al. "Immunomodulatory Protein from Nectria haematococca Induces Apoptosis in Lung Cancer Cells via the P53 Pathway." International Journal of Molecular Sciences 20, no. 21 (2019): 5348. http://dx.doi.org/10.3390/ijms20215348.

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Our previous research has shown that a fungal immunomodulatory protein from Nectria haematococca (FIP-nha) possesses a wide spectrum of anti-tumor activities, and FIP-nha induced A549 apoptosis by negatively regulating the PI3K/Akt signaling pathway based on comparative quantitative proteomics. This study further confirmed that the anti-lung cancer activity of FIP-nha was significantly stronger than that of the reported LZ-8 and FIP-fve. Subsequently, 1H NMR-based metabolomics was applied to comprehensively investigate the underlying mechanism, and a clear separation of FIP-nha-treated and unt

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Erl, Wolfgang, Christian Weber, and Göran K. Hansson. "Pyrrolidine dithiocarbamate-induced apoptosis depends on cell type, density, and the presence of Cu2+and Zn2+." American Journal of Physiology-Cell Physiology 278, no. 6 (2000): C1116—C1125. http://dx.doi.org/10.1152/ajpcell.2000.278.6.c1116.

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Pyrrolidine dithiocarbamate (PDTC) has been found to induce or inhibit apoptosis in different cell types. Here we show that PDTC dose-dependently reduced the viability of rat smooth muscle cells (rSMC), human fibroblasts, and endothelial cells at low but not at high cell density. Endothelial cells were least sensitive, fibroblasts showed a medium sensitivity, and rSMC showed a high sensitivity to PDTC-mediated cell death. An early reduction in the mitochondrial membrane potential indicated a rapid onset of apoptosis in rSMC. Apoptosis was further confirmed by annexin V staining and DNA fragmen

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Corral, Laura G., Dan Zhu, Yuedi Wang, and Bernd Stein. "The IMiDs® Immunomodulatory Drugs Revlimid® (Lenalidomide) and CC-4047 Induce Growth Arrest and Apoptosis in NHL Tumor Cells In Vitro." Blood 108, no. 11 (2006): 2388. http://dx.doi.org/10.1182/blood.v108.11.2388.2388.

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Abstract IMiDs® immunomodulatory drugs are thalidomide analogues that have been developed for improved anti-cancer and anti-inflammatory properties and decreased side effects. Many IMiDs® immunomodulatory drugs have been shown to have activities in hematologic cancers and solid malignancies, as well as having profound effects on the bone marrow microenvironment. Specifically in NHL, it was shown that addition of Revlimid® or CC-4047 to Rituxan enhances anti-tumor activity in a SCID mouse lymphoma model. Here we tested the direct effects of Revlimid® and CC-4047 on NHL tumor cells by treating R

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Swanepoel, Bresler, Luanne Venables, Octavian Olaru, George Nitulescu, and Maryna van de Venter. "In Vitro Anti-proliferative Activity and Mechanism of Action of Anemone nemorosa." International Journal of Molecular Sciences 20, no. 5 (2019): 1217. http://dx.doi.org/10.3390/ijms20051217.

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Anemone nemorosa is part of the Ranunculaceae genus Anemone (order Ranunculales) which comprises more than 150 species. Various parts of the plant have been used for the treatment of numerous medical conditions such as headaches, tertian agues, rheumatic gout, leprosy, lethargy, eye inflammation as well as malignant and corroding ulcers. The Anemone plants have been found to contain various medicinal compounds with anti-cancer, immunomodulatory, anti-inflammatory, anti-oxidant and anti-microbial activities. To date there has been no reported evidence of its use in the treatment of cancer. Howe

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Hideshima, Teru, Dharminder Chauhan, Yoshihito Shima, et al. "Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy." Blood 96, no. 9 (2000): 2943–50. http://dx.doi.org/10.1182/blood.v96.9.2943.

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Abstract Although thalidomide (Thal) was initially used to treat multiple myeloma (MM) because of its known antiangiogenic effects, the mechanism of its anti-MM activity is unclear. These studies demonstrate clinical activity of Thal against MM that is refractory to conventional therapy and delineate mechanisms of anti-tumor activity of Thal and its potent analogs (immunomodulatory drugs [IMiDs]). Importantly, these agents act directly, by inducing apoptosis or G1 growth arrest, in MM cell lines and in patient MM cells that are resistant to melphalan, doxorubicin, and dexamethasone (Dex). More

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Hideshima, Teru, Dharminder Chauhan, Yoshihito Shima, et al. "Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy." Blood 96, no. 9 (2000): 2943–50. http://dx.doi.org/10.1182/blood.v96.9.2943.h8002943_2943_2950.

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Although thalidomide (Thal) was initially used to treat multiple myeloma (MM) because of its known antiangiogenic effects, the mechanism of its anti-MM activity is unclear. These studies demonstrate clinical activity of Thal against MM that is refractory to conventional therapy and delineate mechanisms of anti-tumor activity of Thal and its potent analogs (immunomodulatory drugs [IMiDs]). Importantly, these agents act directly, by inducing apoptosis or G1 growth arrest, in MM cell lines and in patient MM cells that are resistant to melphalan, doxorubicin, and dexamethasone (Dex). Moreover, Tha

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Aung, Kyaw Thu, Kentaro Akiyama, Masayoshi Kunitomo, et al. "Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model." International Journal of Molecular Sciences 21, no. 21 (2020): 8103. http://dx.doi.org/10.3390/ijms21218103.

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Mesenchymal stem cells (MSCs) are known to play important roles in the repair of lost or damaged tissues and immunotolerance. On the other hand, aging is known to impair MSC function. However, little is currently known about how aged MSCs affect the host response to the local inflammatory condition and tissue deterioration in periodontitis, which is a progressive destructive disease of the periodontal tissue potentially leading to multiple tooth loss. In this study, we examined the relationship between aging-induced impairment of MSC function and the severity of periodontal tissue destruction

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Prasad, Ritika, and Biplob Koch. "Antitumor Activity of Ethanolic Extract ofDendrobium formosumin T-Cell Lymphoma: AnIn VitroandIn VivoStudy." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/753451.

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Dendrobium, a genus of orchid, was found to possess useful therapeutic activities like anticancer, hypoglycaemic, antimicrobial, immunomodulatory, hepatoprotective, antioxidant, and neuroprotective activities. The study was aimed to evaluate the anticancer property of the ethanolic extract ofDendrobium formosumon Dalton’s lymphoma.In vitrocytotoxicity was determined by MTT assay, apoptosis was determined by fluorescence microscopy, and cell cycle progression was analysed using flow cytometry;in vivoantitumor activity was performed in Dalton’s lymphoma bearing mice. The IC50value of ethanolic e

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Zhao, Haoran, Minhong Yan, Hua Wang, Sharon Erickson, Iqbal S. Grewal, and Vishva M. Dixit. "Impaired c-Jun Amino Terminal Kinase Activity and T Cell Differentiation in Death Receptor 6–deficient Mice." Journal of Experimental Medicine 194, no. 10 (2001): 1441–48. http://dx.doi.org/10.1084/jem.194.10.1441.

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During an immune response naive T helper (Th) cells differentiate into two functionally distinct subsets, Th1 and Th2, based on their cytokine secretion profile and immunomodulatory function. c-Jun amino terminal kinase (JNK) regulates Th cell differentiation by activating a transcriptional program required for cytokine production. We have recently identified a TNFR superfamily death domain–containing molecule, death receptor (DR)6, which potently activates JNK. T cells from DR6-deficient mice are substantially impaired in JNK activation. When DR6−/− mice were challenged with protein antigen,

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Chhabra, Gagan, Chandra K. Singh, Deeba Amiri, Neha Akula, and Nihal Ahmad. "Recent Advancements on Immunomodulatory Mechanisms of Resveratrol in Tumor Microenvironment." Molecules 26, no. 5 (2021): 1343. http://dx.doi.org/10.3390/molecules26051343.

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Immunomodulation of the tumor microenvironment is emerging as an important area of research for the treatment of cancer patients. Several synthetic and natural agents are being investigated for their ability to enhance the immunogenic responses of immune cells present in the tumor microenvironment to impede tumor cell growth and dissemination. Among them, resveratrol, a stilbenoid found in red grapes and many other natural sources, has been studied extensively. Importantly, resveratrol has been shown to possess activity against various human diseases, including cancer. Mechanistically, resvera

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Tinti, M. G., T. Mazza, L. D’agruma, and A. De Cata. "AB0171 THE IMMUNOMODULATORY AND ANTI-INFLAMMATORY EFFECTS OF BOSENTAN IN SYSTEMIC SCLEROSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1385.2–1386. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6606.

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Background:Plasma endothelin-1 (ET-1) levels are increased in patients with systemic sclerosis (SSc), playing a central role in the development of fibrosis, vasoconstriction and inflammation1. While the beneficial effect of Bosentan, the endothelin receptor antagonists, have been demonstrated on vasoconstriction and fibrosis, its potential anti-inflammatory and immunomodulatory activity needs to be further investigated.Objectives:To assess whether Bosentan can modulate the gene expression profile of immune cells in sample of patients with limited and diffuse SSc and active digital ulcers.Metho

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Jian, Weiguo, Jonathan M. Levitt, Keith S. Chan, Seth P. Lerner, and Guru Sonpavde. "The preclinical anti-angiogenic and pro-apoptotic activity of lenalidomide in urothelial carcinoma (UC)." Journal of Clinical Oncology 31, no. 6_suppl (2013): 294. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.294.

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294 Background: Lenalidomide (Len) is an immunomodulatory drug (IMiD) approved for hematologic conditions and demonstrates immune modulation, anti-angiogenic activity and direct anti-tumor cytotoxicity. A rationale can be made to evaluate the preclinical activity of Len in UC. Methods: The in vitro anti-tumor activity of Len was evaluated in 4 human (5637, TCC-SUP, RT4, RT112) and 1 murine (MB49) cell line. Anti-proliferative activity activity (MTT assay), apoptosis (Annexin-FITC immunohistochemistry [IHC], flow cytometry) and cell viability by colony forming assay were measured. In vivo activ

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Nagaoka, Isao, Kaori Suzuki, François Niyonsaba, Hiroshi Tamura, and Michimasa Hirata. "Modulation of Neutrophil Apoptosis by Antimicrobial Peptides." ISRN Microbiology 2012 (March 27, 2012): 1–12. http://dx.doi.org/10.5402/2012/345791.

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Peptide antibiotics possess the potent antimicrobial activities against invading microorganisms and contribute to the innate host defense. Human antimicrobial peptides, α-defensins (human neutrophil peptides, HNPs), human β-defensins (hBDs), and cathelicidin (LL-37) not only exhibit potent bactericidal activities against Gram-negative and Gram-positive bacteria, but also function as immunomodulatory molecules by inducing cytokine and chemokine production, and inflammatory and immune cell activation. Neutrophil is a critical effector cell in host defense against microbial infection, and its lif

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Barbarossa, Alexia, Alessia Catalano, Jessica Ceramella, et al. "Simple Thalidomide Analogs in Melanoma: Synthesis and Biological Activity." Applied Sciences 11, no. 13 (2021): 5823. http://dx.doi.org/10.3390/app11135823.

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Thalidomide is an old well-known drug that is still of clinical interest, despite its teratogenic activities, due to its antiangiogenic and immunomodulatory properties. Therefore, efforts to design safer and effective thalidomide analogs are continually ongoing. Research studies on thalidomide analogs have revealed that the phthalimide ring system is an essential pharmacophoric fragment; thus, many phthalimidic compounds have been synthesized and evaluated as anticancer drug candidates. In this study, a panel of selected in vitro assays, performed on a small series of phthalimide derivatives,

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Salmond, Robert J., Rachel Williams, Timothy R. Hirst, and Neil A. Williams. "The B Subunit of Escherichia coli Heat-Labile Enterotoxin Induces Both Caspase-Dependent and -Independent Cell Death Pathways in CD8+ T Cells." Infection and Immunity 72, no. 10 (2004): 5850–57. http://dx.doi.org/10.1128/iai.72.10.5850-5857.2004.

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ABSTRACT The nontoxic B subunit of Escherichia coli heat-labile enterotoxin (EtxB) is a potent immunomodulatory molecule that acts both as an adjuvant and to stimulate immune deviation processes, resulting in the suppression of Th1-associated inflammatory responses. The ability of EtxB to alter immune reactivity is dependent on its ability to modulate immune cell function through binding to cell surface molecules, the principal receptor of which is the ubiquitous GM1-ganglioside. EtxB activates B cells and antigen-presenting cells and induces the selective apoptosis of murine CD8+ T cells. We

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Adnan, Israa, and Wamidh Talib. "Do herbal drinks augment the cytotoxic effect against different cancer cells? Are they potent stimulators of innate and acquired immunity?" Journal of Clinical Oncology 38, no. 15_suppl (2020): e21657-e21657. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21657.

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e21657 Background: The herbal drinks are highly prevalent in the Middle East and are consumed in large quantities as daily drinks. Few studies have evaluated the biological activities of the herbal drinks produced from some plants.The current study aims to evaluate the anticancer and immunomodulatory activities of five herbal drinks consumed in the Middle East. These drinks are Palestinian Zhourat, Lebanese Zhourat, Lemon and Ginger combination, Wild Thyme, and Marjoram. Methods: The selected herbal drinks as concentrated water extracts were tested separately for: A. Anti-cancer effect on the

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Chan, Yau, Jack Wong, Evandro Fang, Wenliang Pan, and Tzi Ng. "A Hemagglutinin from Northeast Red Beans with Immunomodulatory Activity and Anti-proliferative and Apoptosis-inducing Activities Toward Tumor Cells." Protein & Peptide Letters 20, no. 10 (2013): 1159–69. http://dx.doi.org/10.2174/0929866511320100011.

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Mohr, Eduarda Talita Bramorski, Marcus Vinicius Pereira dos Santos Nascimento, Júlia Salvan da Rosa, et al. "Evidence That the Anti-Inflammatory Effect of Rubiadin-1-methyl Ether Has an Immunomodulatory Context." Mediators of Inflammation 2019 (November 3, 2019): 1–12. http://dx.doi.org/10.1155/2019/6474168.

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Background. In spite of the latest therapeutic developments, no effective treatments for handling critical conditions such as acute lung injuries have yet been found. Such conditions, which may result from lung infections, sepsis, multiple trauma, or shock, represent a significant challenge in intensive care medicine. Seeking ways to better deal with this challenge, the scientific community has recently devoted much attention to small molecules derived from natural products with anti-inflammatory and immunomodulatory effects. Aims. In this context, we investigated the anti-inflammatory effect

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Blisnick, Adrien, Ladislav Šimo, Catherine Grillon, et al. "The Immunomodulatory Effect of IrSPI, a Tick Salivary Gland Serine Protease Inhibitor Involved in Ixodes ricinus Tick Feeding." Vaccines 7, no. 4 (2019): 148. http://dx.doi.org/10.3390/vaccines7040148.

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Ticks are the most important vectors of pathogens affecting both domestic and wild animals worldwide. Hard tick feeding is a slow process—taking up to several days—and necessitates extended control over the host response. The success of the feeding process depends upon injection of tick saliva, which not only controls host hemostasis and wound healing, but also subverts the host immune response to avoid tick rejection that creates a favorable niche for the survival and propagation of diverse tick-borne pathogens. Here, we report on the molecular and biochemical features and functions of an Ixo

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Cieślak, Marcin, Mariola Napiórkowska, Julia Kaźmierczak-Barańska, et al. "New Succinimides with Potent Anticancer Activity: Synthesis, Activation of Stress Signaling Pathways and Characterization of Apoptosis in Leukemia and Cervical Cancer Cells." International Journal of Molecular Sciences 22, no. 9 (2021): 4318. http://dx.doi.org/10.3390/ijms22094318.

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Based on previously identified dicarboximides with significant anticancer and immunomodulatory activities, a series of 26 new derivatives were designed and synthesized by the Diels–Alder reaction between appropriate diene and maleimide or hydroxymaleimide moieties. The resulting imides were functionalized with alkanolamine or alkylamine side chains and subsequently converted to their hydrochlorides. The structures of the obtained compounds were confirmed by 1H and 13C NMR and by ESI MS spectral analysis. Their cytotoxicity was evaluated in human leukemia (K562, MOLT4), cervical cancer (HeLa),

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Kang, Beomku, Hyunmin Park, and Bonglee Kim. "Anticancer Activity and Underlying Mechanism of Phytochemicals against Multiple Myeloma." International Journal of Molecular Sciences 20, no. 9 (2019): 2302. http://dx.doi.org/10.3390/ijms20092302.

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Multiple myeloma (MM)—a common hematologic malignancy of plasma cells—accounts for substantial mortality and morbidity rates. Due to the advent of novel therapies such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and monoclonal antibodies (mAbs), response rates were increased and free survival and overall survival have been elevated. However, adverse events including toxicity, neuropathy or continuous relapse are still problems. Thus, development of novel drugs which have less side effects and more effective is needed. This review aims to recapitulate the pharmacologic anti-

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Qi, Zeng, Lixue Chen, Zhuo Li, et al. "Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study." International Journal of Molecular Sciences 20, no. 4 (2019): 836. http://dx.doi.org/10.3390/ijms20040836.

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(24R)-pseudo-ginsenoside HQ (R-PHQ) and (24S)-pseudo-ginsenoside HQ (S-PHQ) are the main metabolites of (20S)-ginsenoside Rh2 (Rh2) in vivo. In this study, we found that Rh2, R-PHQ, and S-PHQ upregulated the innate and adaptive immune response in cyclophosphamide (CTX) induced-immunocompromised mice as evidenced by the number of leukocytes, cellular immunity, and phagocytosis of macrophages. Spleen T-lymphocyte subpopulations and the serum cytokines level were also balanced in these immunosuppressed mice. Furthermore, co-administration with R-PHQ or S-PHQ did not compromise the antitumor activ

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Das, Deepika Sharma, Durgadevi Ravillah, Arghya Ray, et al. "Synergistic Anti-Myeloma Activity of a Proteasome Inhibitor Marizomib and IMiD® Immunomodulatory Drug Pomalidomide." Blood 124, no. 21 (2014): 2099. http://dx.doi.org/10.1182/blood.v124.21.2099.2099.

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Abstract Background and Rationale: Proteasome inhibitor bortezomib is an effective therapy for the treatment of relapsed and refractory multiple myeloma (RRMM); however, prolonged treatment can be associated with toxicity, peripheral neuropathy and drug resistance. Our earlier studies showed that a novel proteasome inhibitor marizomib is distinct from bortezomib in its chemical structure, mechanisms of action, and effects on proteasomal activities (Chauhan et al., Cancer Cell 2005, 8:407-419). We also showed that marizomib triggers synergistic anti-MM activity in combination with lenalidomide

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Schade, Andrew E., Gary L. Schieven, Robert Townsend, et al. "Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation." Blood 111, no. 3 (2008): 1366–77. http://dx.doi.org/10.1182/blood-2007-04-084814.

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Abstract Dasatinib is an oral small molecule inhibitor of Abl and Src family tyrosine kinases (SFK), including p56Lck (Lck). Given the central importance of Lck in transmitting signals from the T-cell receptor (TCR) signaling complex and the potent ability of dasatinib to inhibit Lck activity, we hypothesized this agent could provide a novel route of immunomodulation via targeted inhibition of antigen-induced signaling. Herein, we show that dasatinib inhibits TCR-mediated signal transduction, cellular proliferation, cytokine production, and in vivo T-cell responses. However, dasatinib-mediated

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Xu, Zi-hang, Yang-zhuangzhuang Zhu, Lin Su, et al. "Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer." Mediators of Inflammation 2021 (April 1, 2021): 1–20. http://dx.doi.org/10.1155/2021/8856326.

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Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment

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Hussen, Jamal, Mahmoud Kandeel, Turke Shawaf, Abdullah I. A. Al-Mubarak, Naser A. Al-Humam, and Faisal Almathen. "Immunomodulatory Effects of the Cyclooxygenase Inhibitor Lornoxicam on Phenotype and Function of Camel Blood Leukocytes." Animals 11, no. 7 (2021): 2023. http://dx.doi.org/10.3390/ani11072023.

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(1) Background: Lornoxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antiphlogistic and antipyretic effects. The improved tolerance of lornoxicam due to the relatively shorter elimination half-life in comparison to other members of the oxicams may favor its application in the management of pain and inflammation in race dromedary camels. There are no studies conducted yet on the immunomodulatory or immunotoxilogic effect of lornoxicam in camels. Therefore, the current study aimed to evaluate the immunomodulatory effects of the cyclooxygenase inhibitor lornoxicam on some p

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Ratner, Lee, Leon Bernal-Mizrachi, Daniel Rauch, John Harding, Shimon Gross та David Piwnica-Worms. "Bioluminescence Imaging of Spontaneous Lymphomas and Contribution of Distinct NFκB Pathways." Blood 108, № 11 (2006): 2377. http://dx.doi.org/10.1182/blood.v108.11.2377.2377.

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Abstract The nuclear factor κB (NFκB) pathways have been implicated in tumorigenesis in several lymphoid malignancies, but the responsible mechanisms remain to be fully defined. EBV and HTLV-1 immortalized lymphoma cell lines with constitutively active NFκB were found to be resistant to inducers of the extrinsic and intrinsic apoptosis pathways. Several NFκB-target genes were over-expressed in these cell lines, including Bcl-xL, Fas-associated death domain-like IL-1β converting enzyme inhibitor protein (FLIP), and inhibitors of apoptosis (CIAP, XIAP, and survivin). Inhibition of the canonical

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Su, Vincent Yi-Fong, Chi-Shiuan Lin, Shih-Chieh Hung та Kuang-Yao Yang. "Mesenchymal Stem Cell-Conditioned Medium Induces Neutrophil Apoptosis Associated with Inhibition of the NF-κB Pathway in Endotoxin-Induced Acute Lung Injury". International Journal of Molecular Sciences 20, № 9 (2019): 2208. http://dx.doi.org/10.3390/ijms20092208.

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The immunomodulatory effects of mesenchymal stem cells (MSCs) are established. However, the effects of MSCs on neutrophil survival in acute lung injury (ALI) remain unclear. The goal of this study was to investigate the effect of an MSC-conditioned medium (MSC-CM) on neutrophil apoptosis in endotoxin-induced ALI. In this study, an MSC-CM was delivered via tail vein injection to wild-type male C57BL/6 mice 4 h after an intratracheal injection of lipopolysaccharide (LPS). Twenty-four hours later, bronchoalveolar lavage fluid (BALF) and lung tissue were collected to perform histology, immunohisto

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Widelski, Jarosław, Wirginia Kukula-Koch, Tomasz Baj, et al. "Rare Coumarins Induce Apoptosis, G1 Cell Block and Reduce RNA Content in HL60 Cells." Open Chemistry 15, no. 1 (2017): 1–6. http://dx.doi.org/10.1515/chem-2017-0001.

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AbstractThe rare coumarins stenocarpin, stenocarpin isobutyrate, oficinalin, oficinalin isobutyrate, 8-methoxypeucedanin and the known xanthotoxin, isoimperatorin, bergapten, peucedanin and 8–methoxyisoimperatorin were isolated from Peucedanum luxurians Tamamsch. (Apiaceae) and identified by means of spectral data (1D and 2D NMR). Their immunomodulating activity was evaluated by flow cytometry and their influence on HL60 cells as well as on PHA-stimulated PBLs was tested. All tested coumarins induce apoptosis (maximal in the 48 h culture) and decrease cell proliferation in a time- and dose-dep

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