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Dissertations / Theses on the topic 'Immunomodulatory activity'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Magawa, Chandi T. "Anticancer immunomodulatory activity of Melaleuca." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/390028.

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The immune system plays a critical role in disease prevention via collaboration between the adaptive and innate immune responses. Due to a variety of immune cell subpopulations with different functions including opposing roles, the tumour microenvironment provides opportunities as a therapeutic target for anticancer drug development. Recently the essential oils and their extracts from plants have been gaining attention in cancer research, due to their antioxidant and anti-inflammatory activities making them good candidates as sources of novel anticancer compounds. The essential oil of Melaleuc

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2

Fonteh, Pascaline Nanga. "Gold compounds with anti-HIV and immunomodulatory activity." Thesis, University of Pretoria, 2011. http://hdl.handle.net/2263/24951.

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The human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) that subsequently develops remain major health concerns even after three decades since the first cases were reported. Successful therapeutic measures to address HIV/AIDS consist mostly of combinations of drugs targeting viral enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) as well as entry steps of the viral life cycle. The remarkable benefits (e.g. improved quality of life) derived from the use of these agents are unfortunately limited by toxicity to the host and the developmen

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3

Li, Min. "Immunomodulatory activity of polysaccharides from garlic and Chinese yam." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690874.

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4

Lang, Allison K. "A study of human aminotic fluid and its immunomodulatory activity." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386960.

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5

Pearson, Helen. "Investigation of contaminants with immunomodulatory activity in coagulation factor concentrates." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21459.

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The results demonstrate that all conventional and ion-exchange chromatographically purified coagulation factor concentrates inhibit lymphocyte proliferation <I>in vitro. </I>These concentrates also contain measurable amounts of active TGF-β. In contrast, immunoaffinity purified and recombinant coagulation factor concentrates do not inhibit lymphocyte proliferation and contain very little active TGF-β. The levels of TGF-β detected in coagulation factor concentrates correlated with the degree of inhibition of lymphocyte proliferation. However, the amount of TGF-β present in the concentrates coul

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6

Calla-Magariños, Jacqueline. "Bioactive leishmanicidal alkaloid molecules from Galipea longiflora Krause with immunomodulatory activity." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-81439.

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According to WHO, leishmaniasis is endemic in 98 countries, and has been placed ninth in a global analysis of infectious diseases. Treatment of leishmaniasis is based on pentavalent antimonials but toxicity and developing resistance have been reported. Traditional medicine and scientific studies have shown that the extract of Galipea longiflora Krause (Evanta) exhibits antileishmanial activity. We hypothesized that the healing observed when using this plant might not only be due to the direct action on the parasite, but possibly to a parallel effect on the host immune response. We found that a

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7

Amarakoon, A. M. T. "Studies on the antioxidant activity and immunomodulatory properties of black tea." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241795.

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8

Regazzo, Daniela. "Bioactive peptides from milk proteins: focusing on peptides displaying immunomodulatory activity." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3427346.

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Milk-derived peptides are milk components able to influence specific physiologicalfunctions, finally acting on body health condition. At present, the bioactivitiesdescribed for milk-derived peptides include opiate, antithrombotic, antihypertensive, immunomodulating, antioxidative, antimicrobial, anticancer, mineral-carrying andgrowth-promoting activities. In this thesis, special attention has been given to bioactive peptides with ACE-inhibitory and immunomodulatory activities. In the Experiment 1 Enterococcus faecalis TH563 (E. faecalis TH563) and Lactobacillus delbrueckii subsp. bulgaricus

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9

Zhang, Zhengxiao. "Extraction optimization, structure modification and immunomodulatory activity in vitro for arabinoxylans from cereals." Thesis, Manchester Metropolitan University, 2015. http://e-space.mmu.ac.uk/595927/.

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BACKGROUD: The industrial cereal brans produced as by-products of milling have been confirmed to be rich sources of arabinoxylans (AXs). The immunomodulatory properties of the extracted AXs from cereals have been reported, which potentially lead to corresponding health benefit in immune enhancement. However, this requires a clearer understanding of the relationship between the molecular structures of AXs and their immune-modulating activities (the structure-activity relationship). It is also considered essential to gain an understanding of the mechanisms of the immune-modulating properties of

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10

Lins, KÃzia Oliveira Abrantes de Lacerda. "Estudo das atividades antitumoral e inflamatÃria do alginato isolado da alga Sargassum Vulgare C. Agardh." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7855.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>O cÃncer Ã uma doenÃa que afeta cada vez mais um nÃmero maior de pessoas em todo o mundo. As terapias atuais utilizadas para o tratamento do cÃncer sÃo ainda insatisfatÃrias. Produtos naturais tÃm sido avaliados para seleÃÃo de compostos ativos, capazes de reduzir os tumores malignos de uma forma mais eficiente e com menos efeitos indesejÃveis. O alginato extraÃdo da alga Sargassum vulgare C. AGARDH (SVHV) foi testado para avaliaÃÃo do seu potencial antitumoral e imunoestimulante. AlÃm disso, foram feitos testes de toxicidade do

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11

Hengartner, Nina-Emily [Verfasser]. "Immunomodulatory effects and migratory activity of multipotent mesenchymal stromal cells in the posttraumatic inflammatory response / Nina-Emily Hengartner." Ulm : Universität Ulm. Medizinische Fakultät, 2015. http://d-nb.info/1078957568/34.

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12

Kotzerke, Kristina [Verfasser], Michael P. [Akademischer Betreuer] Schön, Holger [Akademischer Betreuer] Reichardt, and Peter [Akademischer Betreuer] Schu. "Immunomodulatory activity of murine keratinocyte-derived exosomes / Kristina Kotzerke. Gutachter: Holger Reichardt ; Peter Schu. Betreuer: Michael P. Schön." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1065881932/34.

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13

Lins, KÃzia Oliveira Abrantes de Lacerda. "Estudo das atividades antitumoral e imunoestimulante do polissacarÃdeo sulfatado isolado de Champia feldmannii Diaz-Pifferer (1977)." Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1832.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>O cÃncer Ã uma doenÃa que afeta cada vez mais um nÃmero maior de pessoas em todo o mundo. As terapias atuais utilizadas para o tratamento do cÃncer sÃo ainda insatisfatÃrias. Produtos naturais tÃm sido avaliados para seleÃÃo de compostos ativos, capazes de reduzir os tumores malignos de uma forma mais eficiente e com menos efeitos indesejÃveis. O polissacarÃdeo sulfatado extraÃdo da alga Champia feldmannii (Cf-PLS) foi testado para avaliaÃÃo do seu potencial antitumoral e imunoestimulante. AlÃm disso, foram feitos testes de toxic

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14

Clark, Amanda. "Melaleuca Alternifolia Concentrate (MAC): A Plant-Derived Anticancer Agent." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367678.

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Natural products historically represent a source of clinically approved drugs that have contributed significantly to anticancer drug development. In particular, essential oils represent a group of advantageous anticancer candidates as not only can they be produced in large quantities in a cost-effect manner but they also exhibit minimal toxicity. Melaleuca alternifolia Concentrate (MAC) is an extract prepared from the native Australian plant M. alternifolia (also a common source of Tea Tree Oil). Melaleuca oils are commonly used products, primarily utilised and investigated for their antimicro

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15

Iyer, Chandra. "Studies on co-encapsulation of probiotics and prebiotics and its efficacy in survival, delivery, release and immunomodulatory activity in the host intestine." Thesis, View thesis, 2005. http://handle.uws.edu.au:8081/1959.7/39088.

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Oral administration of live probiotics such as Lactobacillus and Bifidobacterium spp. possess numerous beneficial effects. However, delivering viable probiotics to the host intestine has been a challenge due to poor survival of these bacteria during the gastric transit. An improved oral delivery system (modified alginate microcapsules) was developed in this study for targeted release of viable probiotics to the host intestine. Effect of various encapsulation parameters such as capsule size, alginate concentration, calcium chloride concentration, gelling/hardening time of microcapsules, additio

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Iyer, Chandra. "Studies on co-encapsulation of probiotics and prebiotics and its efficacy in survival, delivery, release and immunomodulatory activity in the host intestine." View thesis, 2005. http://handle.uws.edu.au:8081/1959.7/39088.

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Thesis (Ph.D.)--University of Western Sydney, 2005.<br>A thesis submitted to the University of Western Sydney, College of Health and Science, Centre for Plant and Food Science, in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliographies.

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17

Paes, Jéssica Andrade. "Caracterização funcional e imunológica da sinal-peptidase I de Mycoplasma hyopneumoniae." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/117916.

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A bactéria Mycoplasma hyopneumoniae é um patógeno suíno economicamente significante, que se adere às células do epitélio respiratório causando a pneumonia enzoótica suína (PES). A adesão celular e outros processos importantes para infecção dependem de proteínas de membrana, cuja maioria é transportada pela via de exportação Sec-dependente. A sinal-peptidase tipo I (SPase I) é uma protease de membrana que atua na liberação de proteínas translocadas através da via Sec-dependente. Neste contexto, a SPase I possui participação crítica na exportação de proteínas que podem atuar nas relações patógen

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18

Barreiros, André Luís Bacelar Silva. "Constituintes químicos bioativos de dioclea violacea." Programa de Pós-Graduação em Química da UFBA, 2005. http://www.repositorio.ufba.br/ri/handle/ri/9952.

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Sansone, Ana Claudia Miranda Brito. "Ocorrência e distribuição de BanLec em cultivares de banana e avaliação da sua atividade imunomoduladora in vivo." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-27052015-120249/.

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Lectinas são proteínas cuja principal característica é a de se ligar específica e reversivelmente a carboidratos. BanLec é a lectina presente na polpa de bananas, que se liga especificamente a manose e glicose, e é capaz de induzir a proliferação de células T, podendo estimular a resposta imune. Existem indícios de que o teor de BanLec pode variar dependendo do estádio de amadurecimento e do tipo de cultivar, o que pode afetar a quantidade de BanLec existente na fruta quando consumida in natura e a possível resposta imune frente ao consumo de banana. Por este motivo, um dos objetivos desse tra

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20

Santos, Rogerio Alexandre Nunes dos. "Avaliação da Atividade Antileishmania da Spiranthera odoratissima ST. Hil (Rutaceae) in vitro, in vivo e in silico." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/6837.

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Made available in DSpace on 2015-05-14T13:00:09Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1776418 bytes, checksum: 744ac3ac5030bc552fceb05b70d06ca5 (MD5) Previous issue date: 2015-03-02<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Leishmaniasis is one of the neglected diseases. High cost, systemic toxicity, and diminished efficacy due to development of resistance by the parasites has a negative impact on the current treatment options. Thus, the search for a new, effective and safer antileishmanial drug becomes of paramount importance. Compounds derived fro

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21

Becker, Veit, Volker Heeschen, Katrin Schuh, Heinke Schieb, and Tjalf Ziemssen. "Patient satisfaction and healthcare services in specialized multiple sclerosis centres in Germany." Sage, 2018. https://tud.qucosa.de/id/qucosa%3A35542.

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Background: As patients with multiple sclerosis (MS) require lifelong treatment, optimization of therapy with respect to efficacy and safety is needed to limit long-term disease progression. Patients with MS also need a range of health-related services. Satisfaction with these as well as treatment is clinically relevant because satisfied patients are more likely to adhere to therapy. The aim of this study was to determine the status of patient satisfaction and of healthcare services in 70 specialized MS centres in Germany. Methods: In 2011, patients with MS responded to a questionnaire, which

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22

PEREIRA, Flávia de Castro. "Avaliação do Potencial Citotóxico, Genotóxico e Antitumoral do Ditionato de cis-Tetraamino(oxalato)rutênio(III) em Diferentes Linhagens Celulares." Universidade Federal de Goiás, 2010. http://repositorio.bc.ufg.br/tede/handle/tde/1288.

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Made available in DSpace on 2014-07-29T15:16:36Z (GMT). No. of bitstreams: 1 Dissertacao Flavia de Castro Pereira UFG 2010 - part 1.pdf: 495954 bytes, checksum: 284a68ffbde993ede09791444dec1865 (MD5) Previous issue date: 2010-01-22<br>Despite the resounding success of cisplatin and closely related platinum antitumor agents, the movement of other transition-metal antitumor agents toward the clinic has been exceptionally slow. Non-Platinum chemotherapeutic metallopharmaceuticals hold much promise for the future, and needs to be actively explored in a large variety of tumor types in combination

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23

Ilboudo, P. D. "IN VITRO THERAPEUTIC VALUE OF PLANT EXTRACTS USED IN BURKINA FASO TO TREAT MALARIA AND IN VITRO PHARMACODYNAMIC STUDIES OF ANTIMALARIAL DRUGS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/171918.

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My PhD project has developed in two main research areas, both related to antimalarial drug discovery. The first part was focused on the study of the antimalarial and anti-inflammatory activity of medicinal plants used in Burkina Faso to treat malaria; the second part was dedicated to the development of new tools to measure in vitro the pharmacodynamic characteristics of current or new drugs to predict early on their clinical behavior. The work was conducted in the Laboratory of Parasitology, Department of Public Health- Microbiology -Virology of the University of Milan and at the Liverpool Sch

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24

Mendis, Mihiri Marini. "Structurally Diverse Arabinoxylan Hydrolyzates: Their Activity as Immunomodulators and their Effect on Growth of Bacteroidetes." Diss., North Dakota State University, 2015. https://hdl.handle.net/10365/27413.

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Arabinoxylan (AX) is a plant polysaccharide which consists of a xylan backbone on which arabinose is substituted. Thirty structurally different wheat arabinoxylan hydrolyzates (AXH) were prepared by means of different combinations of xylanase (Cellvibrio japonicas xylanase (CJX) and Aspergillus niger xylanase (ANX)) and arabinofuranosidase (Bifidobacterium adolescentis arabinofuranosidase (BAF) and Clostridium thermocellum arabinofuranosidase (CAF)). The AXH were analyzed using GC-FID, GC-MS, 1H-NMR and SEC-MALS techniques. In general, the AXH had high proportion of unsubstituted xylose and le

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25

Ben, Rhouma-Martin Ghada. "Oligomérisation enzymatique de flavonoïdes et évaluation des activités biologiques des oligomères synthétisés." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0017/document.

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L'oligomérisation enzymatique de la rutine et esculine a donné lieu à cinq fractions d'oligomères de masse moléculaire moyenne entre 2127,42 et 8331,85 g/mol pour la rutine et 688,12 et 6973 g/mol pour l'esculine. L'analyse de ces fractions par FTIR montre que les fractions d'oligorutines sont obtenues à travers des liaisons C-C, C-O et C=O. Les fractions d'oligoesculines sont obtenues à travers des liaisons C-C. Une meilleure solubilité des oligorutines et des oligoesculines dans l'eau et une plus faible solubilité de ces oligomères dans l'éthanol comparé à leurs monomères a été mis en éviden

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26

VIDAUD, LIONEL. "Structure et conformation de cyclophosphazenes porteurs de polyamines en configurations naturelles ou exotiques." Toulouse 3, 1987. http://www.theses.fr/1987TOU30234.

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27

Rouger, Caroline. "Activité pharmacologique de dérivés polyphénoliques isolés de Clusiaceae et de Calophyllaceae malaisiennes : effets régulateurs sur des marqueurs endothéliaux de l’inflammation et de l’immunité." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0066/document.

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Afin d’identifier de nouveaux composés prévenant la dysfonction et l’immunogénicité des cellules endothéliales qui sont impliquées dans la survenue des rejets de greffe,nous nous sommes intéressés aux métabolites secondaires de différentes espèces de Clusiaceae et de Calophyllaceae. Tout d’abord, 4 extraits DCM de Calophyllaceae malaisiennes ont été sélectionnés sur la base d’une étude déréplicative et d’un criblage biologique anti-inflammatoire. Puis, l’étude phytochimique de l’extrait de fruits de Mesua lepidota a permis d’isoler 9 coumarines de type mammea, dont 7 constituent 2 nouvelles sé

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28

Hietter, Hélène. "Activites biologiques des hydroxysterols : cytotoxicite selective et immunomodulation." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13323.

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29

Telvi, Louise. "Effets des immunomodulateurs sur certaines fonctions lymphocytaires T." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37610262p.

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30

Derrien, Danièle. "Modulateur de la réponse immune : ciblage par des polymères glycosyles reconnus par les lectines membranaires des macrophages murins." Orléans, 1988. http://www.theses.fr/1988ORLE2037.

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Realisation d'un vecteur reconnu par les lectrines membranaires des macrophages et destine a transporter le n-acetylmuramyl dipeptide vers ces cellules. L'efficacite de ce vecteur est etudiee in vitro et in vivo sur des modeles murins. L'activation du macrophages a ete evaluee par la cytostase exercee vis-a-vis des cellules tumorales et par la secretion d'interleukine 1 et de facteur de necrose tumorale

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31

Florentin, Irène. "Caracterisation fonctionnelle comparative de substances immunomodulatrices." Paris 6, 1987. http://www.theses.fr/1987PA066374.

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32

Othmane, Omar. "Mecanisme d'action d'un immunomodulateur, le lf 1695 : effets in vitro et in vivo sur les lymphocytes t et sur l'autoimmunite." Limoges, 1986. http://www.theses.fr/1986LIMO0027.

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33

Che-Jung and 胡哲榮. "Immunomodulatory activity of Fungal Immunomodulatory Proteins." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/64967293150057571500.

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碩士<br>中山醫學大學<br>醫學分子毒理學研究所<br>94<br>Two fungal immunomodulatory proteins (FIPs) have been isolated, purified from the edible mushroom Ganoderma tsugae and Flammulina velutipes and designated FIP-gts and FIP-fve, respectively. They have immunomodulatory activities. Using six different carbohydrate to trace which is the FIP-gts and FIP-fve binding receptor on human peripheral blood mononuclear cells (HPBMCs) plasma membrane by competition assay for receptor strategy. We could not find that which receptor involved in endocytosis for FIP-gts and FIP-fve. Analyzing the IFN-gamma induced by FIP-gts

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Liao, Yu-Ting, and 廖昱婷. "Immunomodulatory activity of lactic acid bacteria." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/93209189109951850150.

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碩士<br>國立中興大學<br>食品科學系<br>92<br>The stimulatory effect of eight strains of lactic acid bacteria including L. acidophilus 4356, L. acidophilus LA-1, L. bulgaricus 448, L. bulgaricus 449, B. longum B6, B. longum 15708, S. thermophilus MC and S. thermophilus 573 on murine macrophage J774A.1 cell line were examined. The fractions of lactic acid bacteria including viable bacteria, heat-killed bacteria, intracellular extract, extracellular extract, crude cell wall, chromosome DNA, and whey of fermented milk were used for this study. The testing items include proliferation, the secretion of TNF-α and

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Kotzerke, Kristina. "Immunomodulatory activity of murine keratinocyte-derived exosomes." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0023-9979-C.

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Dixit, Akanksha. "Immunomodulatory Activity of Glycodelin : Implications in Allograft Rejection." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/3715.

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Glycodelin, a homodimeric glycoprotein belonging to the lipocalin superfamily, is synthesised predominantly by the cells of the reproductive system of certain primates including humans. Of the four different known glycoforms of the molecule, glycodelin A (GdA), secreted by the glandular epithelial cells of the endometrium in response to progesterone, is involved in the immunosuppression of the maternal immune response to the semi-allograft fetus. GdA secretion onsets few days after ovulation. In the absence of fertilization, GdA levels drop, but subsequent to a successful fertilization, the co

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Dixit, Akanksha. "Immunomodulatory Activity of Glycodelin : Implications in Allograft Rejection." Thesis, 2017. http://etd.iisc.ernet.in/2005/3715.

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Glycodelin, a homodimeric glycoprotein belonging to the lipocalin superfamily, is synthesised predominantly by the cells of the reproductive system of certain primates including humans. Of the four different known glycoforms of the molecule, glycodelin A (GdA), secreted by the glandular epithelial cells of the endometrium in response to progesterone, is involved in the immunosuppression of the maternal immune response to the semi-allograft fetus. GdA secretion onsets few days after ovulation. In the absence of fertilization, GdA levels drop, but subsequent to a successful fertilization, the co

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Chen, Yu-Han, and 陳郁涵. "Immunomodulatory activity of Lactobacillus sp.YM0547 in an allergic mouse model." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/97940828704468106979.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>101<br>It has been reported that some lactic acid bacteria strains or traditional Chinese medicine could ameliorate symptoms of allergic diseases. This study aimed to investigate immunomodulatory effects of Lactobacillus sp. YM0547 on human peripheral blood mononuclear cells (hPBMC) and ovalbumin (OVA)-sensitized mice, further to explore effects of YM0547 combined with Astragalus membranaceous (AM) aqueous extracts on a mouse model of allergic asthma. Our results showed that YM0547 increased the production of interferon-γ (IFN-γ), a Th1 cytokine, by hPBMC. Oral ad

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邱文瑩. "Evaluation of Function of Immunomodulatory Activity for Lactic Acid Bacteria." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/79688403796693621111.

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碩士<br>國立屏東科技大學<br>食品科學系所<br>96<br>Atopic disease is showing a steadily increasing prevalence in highly industrialized countries. Recent reports have indicated that decreased exposure to microbial stimuli has been proposed to be involved in the increased prevalence of atopic disease. However, modification of the intestinal flora early in life by administration of probiotic bacteria may be a potential approach to prevent atopic disease. Probiotic bacteria as lactic acid bacteria (LAB) present in fermented foods or belonging to the natural intestinal microflora were shown to exert beneficial effe

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Yang, Feng-Hsu, and 楊豐旭. "Studies on the Expression of Fungal Immunomodulatory Protein from Flammulina velutipes in Lactic Acid Bacteria and its Immunomodulatory Activity." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/95184283139497281817.

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碩士<br>國立臺灣大學<br>園藝學研究所<br>95<br>The objectives of this study were to construct a heteroprotein expression system of lactic acid bacteria (LAB), to express an immunomodulatory protein from Flammulina velutipes (fve) in recombinant LAB strain, and to study the immunoregulatory activity of fve-expressing LAB strains in vivo. In this study, the LAB expression vector pLP-LT1 was constructed based on shuttle vector pLP3537 as a backbone with a plac promoter from Lactobacillus casei ATCC 393 and a lamda terminator from E.coli vector pQE30. The genes encoding hisfve and fve were cloned to generate th

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Cheng, Shu-Yun, and 鄭淑云. "Studies of Submerged Culture and Immunomodulatory Activity of Grifola frondosa TSRI01." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/71908240152850899639.

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碩士<br>嘉南藥理科技大學<br>生物科技系暨研究所<br>94<br>Polysaccharides isolated from maitake (Grifola frondosa) fruiting bodyhave been used as dietary supplements due to their antitumor and immunomodulatory properties. The objective of this research was to optimize the conditions to produce the maximum amount of mycelia biomass by Grifola frondosa TSRI01 in submerged culture. This research was to produce and characterize the immunomodulatury functional polysaccharides of G. frondosa TSRI01.The optimal fermentation in a 5 L jar fermenter for 7days.The final biomass yield was 10.37g/L. G. frondosa was cultivated

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Shiu, Fu-Shiang, and 許富翔. "Immunomodulatory and Antioxidative Activity of Lactic Acid Fermented Defatted Sesame Meal." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/98861679044628945657.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>97<br>Sesame meal obtained from oil extraction of sesame. The main composition is protein and was commonly used as feed ingredients or compost for domestic animals. Sesame meal contains lignan compounds which have been proven to exert many biological activties. Studies indicated that sesaminol triglucoside in sesame seeds are the major lignans that display biological activities. The antioxidative activities of sesaminol triglucoside were weak in vitro, but they have been reported to suppress oxidative stress after being metabolized or hydrolized in vivo. Lactic acid

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Hsu, Shao-Kang, and 許劭康. "Immunomodulatory Activity of Extracts of Mycelium and Fruiting Body from Xylaria nigripes." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/65419288078494715191.

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碩士<br>大葉大學<br>生物產業科技學系<br>102<br>Xylaria nigripes (XN) is called Wu-Ling-Sheng (WLS) in Chinese and belongs to Xylariaceae family. X. nigripes is a medicinal fungus with highly economic value. It grows in soil-dwelling termites abandoned nest underground. Its biological functions include using as a diuretic, enhancing immunity, improving sleep and other effects. Researchers have shown that XN can do DPPH scavenging, and has functions such as sedative hypnotic, anxiolytic, antidepressant, anti-prostate hyperplasia and enhance immunity and so on. Inflammation is a protective physiological re

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Shih, Pin-Tsen, and 施品岑. "Immunomodulatory activity of polysaccharides isolated from Chenopodium formosanum Koidz in macrophage model." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/26938815205821165798.

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碩士<br>國立屏東科技大學<br>食品科學系所<br>100<br>Macrophages are phagocytic cells widely distributed throughout the body, and play an essential role in innate immunity and inflammatory responses. Many polysaccharides isolated from plants are considered to be biological response modifiers and have been shown to enhance various immune responses in vivo and in vitro. In the present study, Djulis polysaccharide was isolated from Chenopodium formosanum seeds. It’s immune activity in mouse microphage model was investigated. We found that Djulis polysaccharide induced morphological changes of macrophages. Various

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Chien, Yu-Chin, and 簡佑家. "Effects of ball milled Dang-Gui and Jiaogulan extracts on antitumor and immunomodulatory activity." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/75244249319586720855.

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碩士<br>輔仁大學<br>食品科學系<br>97<br>Jiaogulan (Gynostemma pentaphyllum (thunb.) Makino) is a species of Cucurbitaceae, it is noted for its functions to treat hepatitis and cardiovascular diseases in Asia. Dang-Gui (Angelica sinensis (Oliv.) Diels) is a species of Umbelliferae, it is one of the most important Chinese medicinal herbs used mainly for the treatment of diseases such as gynecopathy and liver disorders. Ball-milling pulverizes the structure of Chinese herbs and reduces the particle size, and it also raises the efficiency of absorption to increase as the surface. The objective of this study

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Alizadehsadrdaneshpour, Mohammadali. "YEAST PRODUCTS AS POTENTIAL SOURCES OF IMMUNOMODULATORY AND GROWTH PROMOTING ACTIVITY FOR BROILER CHICKENS." 2015. http://hdl.handle.net/1993/30785.

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The use of antibiotic growth promoters has been limited all around the world because of the concerns about antibiotic resistant bacteria and the presence of antibiotic residues in poultry products. Yeast-derived products are rich sources of ß1,3-1,6-glucan, mannan polysaccharides, and nucleotides and are considered as possible antibiotic alternatives due to their potential intestinal health benefits, growth promotion, and immune system stimulation. The objectives of the current research were: (1) to the evaluate effect of yeast products derived from yeast Saccharomyces cerevisiae on growth per

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Amorim, Jéssica Ferreira. "Immunomodulatory and antimicrobial activity of SAAP-148 in solution and released from PLGA coatings." Master's thesis, 2020. https://hdl.handle.net/10216/130375.

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Amorim, Jéssica Ferreira. "Immunomodulatory and antimicrobial activity of SAAP-148 in solution and released from PLGA coatings." Dissertação, 2020. https://hdl.handle.net/10216/130375.

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Su, Heng-Kuan, and 蘇恒寬. "Immunomodulatory Activity of Fermented Milk Containing Lactobacillus casei Strain Shirota in BALB/c Mice." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/85994575131231008370.

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碩士<br>臺灣大學<br>食品科技研究所<br>95<br>The physiological functions of lactic acid bacteria (LAB) include improving intestinal tract health, reducing symptoms of lactose intolerance, decreasing blood serum cholesterol and enhancing the immune system. The aim of this study is to evaluate the immunomodulatory effects of fermented milk with Lactobacillus casei strain Shirota (LcS) in BALB/c mice. The animal models were used to evaluate for non-specific and specific immune responses on the basis of the regulations of “Health-Promoting Food” of FDA, Taiwan. In this experiment, 60 BALB/c mice were divided in

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Tsai, Tzu-Wen, and 蔡慈雯. "Study of the relationship between antiproliferation activity and fungal immunomodulatory protein structure of Ganoderma tsugae." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/64571219615192981134.

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碩士<br>國立高雄海洋科技大學<br>海洋生物技術研究所<br>101<br>The fungal immunomodulatory protein (FIP), a small molecular-weight protein, is purified from Ganoderma tsugae mycelia. It have been shown that FIP have immunomodulatory and anti-cancer effects. Our previous study also showed that FIP could inhibit growth of HL-60 and Jurkat leukemia cell lines. However, the molecular mechanism is unclear. In this study, we focused on the relationship between antiproliferation activity and FIP structure. Our results showed that FIP N-terminal 13 amino acids could induce cell aggregation, the others FIP residues (FIPΔN13)

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