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Dissertations / Theses on the topic 'Immunomodulatory and anti-inflammatory activity'

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Published: 4 June 2025
Last updated: 1 August 2025

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1

Fonteh, Pascaline Nanga. "Gold compounds with anti-HIV and immunomodulatory activity." Thesis, University of Pretoria, 2011. http://hdl.handle.net/2263/24951.

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The human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) that subsequently develops remain major health concerns even after three decades since the first cases were reported. Successful therapeutic measures to address HIV/AIDS consist mostly of combinations of drugs targeting viral enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) as well as entry steps of the viral life cycle. The remarkable benefits (e.g. improved quality of life) derived from the use of these agents are unfortunately limited by toxicity to the host and the developmen
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2

Paes, Jéssica Andrade. "Caracterização funcional e imunológica da sinal-peptidase I de Mycoplasma hyopneumoniae." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/117916.

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A bactéria Mycoplasma hyopneumoniae é um patógeno suíno economicamente significante, que se adere às células do epitélio respiratório causando a pneumonia enzoótica suína (PES). A adesão celular e outros processos importantes para infecção dependem de proteínas de membrana, cuja maioria é transportada pela via de exportação Sec-dependente. A sinal-peptidase tipo I (SPase I) é uma protease de membrana que atua na liberação de proteínas translocadas através da via Sec-dependente. Neste contexto, a SPase I possui participação crítica na exportação de proteínas que podem atuar nas relações patógen
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3

Hengartner, Nina-Emily [Verfasser]. "Immunomodulatory effects and migratory activity of multipotent mesenchymal stromal cells in the posttraumatic inflammatory response / Nina-Emily Hengartner." Ulm : Universität Ulm. Medizinische Fakultät, 2015. http://d-nb.info/1078957568/34.

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4

Clark, Amanda. "Melaleuca Alternifolia Concentrate (MAC): A Plant-Derived Anticancer Agent." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367678.

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Natural products historically represent a source of clinically approved drugs that have contributed significantly to anticancer drug development. In particular, essential oils represent a group of advantageous anticancer candidates as not only can they be produced in large quantities in a cost-effect manner but they also exhibit minimal toxicity. Melaleuca alternifolia Concentrate (MAC) is an extract prepared from the native Australian plant M. alternifolia (also a common source of Tea Tree Oil). Melaleuca oils are commonly used products, primarily utilised and investigated for their antimicro
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5

Zhai, Zili. "Immunomodulatory, anti-inflammatory and wound healing properties of Echinacea species." [Ames, Iowa : Iowa State University], 2008.

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6

Yu, Xiaojie. "Immunomodulatory properties of IgG glycosylation and the anti-inflammatory mechanism of intravenous immunoglobulin." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:140048b3-7cf4-4a30-932b-59c3e1d20272.

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The IgG Fc domain mediates a range of antibody effector functions, including antibody dependent cell-mediated cytotoxicity (ADCC), complement activation, phagocytosis, and the recently emerged general anti-inflammatory effect of immunoglobulin therapy (IVIg). The conserved N-glycan attached to Fc N297 maintains the Fc structural integrity for the effector functions, while its glycoform is known to modulate the affinity for the Fc γ-receptors (FcγRs), complement, and the C-type lectin DC-SIGN. IgG Fc exhibits protein-directed glycosylation characterized by a series of biantennary complex type g
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7

Mazumder, Tamal. "Characterization of anti-inflammatory and immunomodulatory properties of the extract from the leaves of eupatorium adeuphorum." Thesis, University of North Bengal, 2010. http://hdl.handle.net/123456789/1147.

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8

Gregg, Catherine Nicola. "Structure-activity studies in non-steroidal anti-inflammatory drugs." Thesis, Liverpool John Moores University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238686.

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9

SILVESTRINI, ANDREA. "Anti-inflammatory and anti-adipogenic activity of olive leaf extract and its bioactive compounds." Doctoral thesis, Università Politecnica delle Marche, 2022. https://hdl.handle.net/11566/299341.

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Le foglie d’olivo sono un materiale di scarto dell’industria dell’olio di oliva, uno degli alimenti alla base della dieta mediterranea. Negli ultimi anni la ricerca scientifica si è soffermata sulla possibilità di un riutilizzo di questo materiale data la sua ricchezza di composti bioattivi potenzialmente applicabili in ambito biomedico. Lo scopo di questo studio è stato quello di caratterizzare e valutare l’effetto anti-infiammatorio e anti- adipogenico di un estratto acquoso di foglie di olivo (OLE). L’estratto, prodotto nel nostro laboratorio a partire da foglie essiccate raccolte da
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10

Kamonpatana, Kom. "Metabolism and Anti-inflammatory Activity of Anthocyanins in Human Oral Cavity." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354655642.

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11

Hammer, Kimberly Dawn Petry. "Elucidation of anti-inflammatory constituents in Hypericum perforatum extracts and delineation of mechanisms of anti-inflammatory activity in RAW 264.7 mouse macrophages." [Ames, Iowa : Iowa State University], 2008.

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12

García, Piñeres Alfonso J. "Contribution to the elucidation of the anti-inflammatory activity of sesquiterpene lactones." [S.l.] : [s.n.], 2003. http://www.freidok.uni-freiburg.de/volltexte/698.

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13

Poelstra, Klaas. "Glomerular adenine nucleotidases a study into the anti-thrombotic and anti-inflammatory activity of the rat kidney /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1992. http://irs.ub.rug.nl/ppn/291022685.

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14

Lobb, Ian Thomas. "The role of nucleolar stress in the anti-tumour activity of non-steroidal anti-inflammatory drugs (NSAIDs)." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17878.

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Overwhelming evidence indicates that aspirin (ASA) and related non-steroidal anti-inflammatory drugs (NSAIDs) have anti-tumour activity against colorectal cancer (CRC). Although the underlying mechanisms have yet to be fully elucidated, the host laboratory have shown that nucleolar sequestration of the NF-κB component RelA is critical. In the course of these studies, it was noted that alongside effects on the NF- κB pathway, ASA has a profound effect on nucleoli, including a dramatic increase in nucleolar size. These data were particularly interesting as, in addition to its role in ribosome bi
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15

Klimuk, Sandra K. "Liposome encapsulation enhances the anti-inflammatory activity of an ICAM-1 antisense oligonucleotide." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ46365.pdf.

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16

Dixon, Natalie Claire. "Anti-inflammatory and immunoprotective effects of regular physical activity and/or caloric restriction." Thesis, University of Bath, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521013.

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17

Alleyne, Jerusalem. "Investigation into the anti-inflammatory activity of PXR and the minor isoform PXR3." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.662201.

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The Pregnane X receptor (PXR) , is a nuclear receptor (NR) which heterodimerizes with RXRa (Retinoid X Receptor alpha) to regulate xenobiotic metabolism. The NR1I2 gene produces three isoforms, PXR1, PXR2 and PXR3. However, only the function of the major isoform PXRl is known. Moreover, PXR has been shown to have an anti-inflammatory function. This is interesting, since the processes of xenobiotic metabolism and inflammation antagonize each other. The mechanism by which PXR performs this anti-inflammatory function remains unclear. However, other nuclear receptors such as PPARa and PPARy repres
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18

Darweesh, Ruba. "IN VITRO LUNG EPITHELIAL CELL TRANSPORT AND ANTI-INFLAMMATORY ACTIVITY FOR LIPOSOMAL CIPROFLOXACIN." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/577.

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Liposomal ciprofloxacin (Lipo-CPFX) is being developed for inhalation, with a goal of sustaining the therapeutic activity, compared to unformulated ciprofloxacin (CPFX). However, the kinetics and mechanism of its sustained local lung retention and pharmacological activity are yet to be fully characterized. This project hypothesized that Lipo-CPFX enables slower and sustained lung epithelial transport and uptake, compared to CPFX, thereby producing prolonged local pharmacological actions. The human bronchial epithelial Calu-3 cells were used as monolayers to characterize the kinetics and mechan
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19

Wisman, Kimberly N. "I. Cytotoxicity and anti-inflammatory activity of polyphenolics. II. Polyphenolics in natural soils." Oxford, Ohio : Miami University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1217016926.

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20

Bruno, Ferdinando. "Design, synthesis and biological evaluation of new small molecules with anti-inflammatory activity." Doctoral thesis, Universita degli studi di Salerno, 2015. http://hdl.handle.net/10556/1851.

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Per lipossigenasi (nota più comunemente con l'abbreviazione di LOX o LO) si intende una famiglia eterogenea di enzimi in grado di perossidare i lipidi e di causare l'ossigenazione di acidi grassi polinsaturi trasformandoli, così, nei corrispettivi derivati idroperossidici. Nello specifico, la 5-LO rappresenta l'enzima chiave nell'ossidazione dell'acido arachidonico (AA) in LTA4, intermedio indispensabile per la sintesi dei leucotrieni, potenti mediatori flogistici coinvolti in una serie di differenti processi patologici. Va da sé che l'inibizione, dell'attività di tale enzima, induce la dirett
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21

Ganzetti, G. S. "USE OF GENETICALLY MODIFIED MICE TO STUDY THE ANTI-INFLAMMATORY AND IMMUNOMODULATORY ROLE OF HIGH-DENSITY LIPOPROTEINS DURING ATHEROSCLEROSIS DEVELOPMENT." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/482886.

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Introduction: High-density lipoproteins (HDLs) have several anti-atherosclerotic/anti-inflammatory properties and the apolipoprotein A-I (apoA-I), the main protein component of HDL, plays a major role. The aim of the present project was to investigate the impact of apoA-I on atherosclerosis development, phenotype and inflammation, through the use of genetically modified mice. Methods: This study was performed in C57Bl/6 wild-type mice, resistant to atherosclerosis development, and in three athero-prone mouse lines: apoEKO, apoEKO with the additional deletion of murine apoA-I (dKO) and dKO ove
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22

Potenza, Marianna. "Computational chemistry techniques for the design and the synthesis of molecules with anti-inflammatory and anti-tumor activity." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4270.

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2017 - 2018<br>In the last few years, computational chemistry has played an important role in disclosing novel compounds with relevant biological activity. Inflammation and cancer processes have been recently linked, and the identification of new molecular entities able to interfere with biological targets involved in these pathologies is strongly needed. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding modes” are the starting points in the design and the identification of new and more powerful drugs. Also, in silico Virtual Screening campaigns of large
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23

Popov, Cláudia Sofia de Freitas Correia. "Caracterização estrutural e funcional de peptídeos isolados da derme de Hypsiboas raniceps (Anura)." Universidade Católica de Brasília, 2018. https://bdtd.ucb.br:8443/jspui/handle/tede/2497.

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Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-11-16T19:33:03Z No. of bitstreams: 1 ClaudiaSofiadeFreitasCorreiaPopovTeseParcial2017.pdf: 709320 bytes, checksum: 74c3fb3e34fa9828bc490124e9d19b7b (MD5)<br>Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-11-16T19:33:23Z (GMT) No. of bitstreams: 1 ClaudiaSofiadeFreitasCorreiaPopovTeseParcial2017.pdf: 709320 bytes, checksum: 74c3fb3e34fa9828bc490124e9d19b7b (MD5)<br>Made available in DSpace on 2018-11-16T19:33:23Z (GMT). No. of bitstreams: 1 ClaudiaSofiadeFreitasCorreiaPopovTeseParcial2017.pdf: 709320 bytes, c
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24

Ordway, Gregory A., W. D. Gill, J. B. Coleman, Hui Wang-Heaton, and Russell W. Brown. "Anti-Inflammatory PARP Inhibitor Demonstrates Antidepressant Activity in Animal Model of Treatment Resistant Depression." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/8643.

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Background: Major depressive disorder is associated with elevated levels of DNA oxidation, DNA damage, and gene expression of DNA repair enzymes including poly (ADP-ribose) polymerase-1 (PARP1). Elevated PARP1 activity is directly linked to neuroinflammation and PARP inhibitors are anti-inflammatory and neuroprotective. We previously showed that PARP inhibitors produce antidepressant-like effects equivalent to fluoxetine in rodent models. Here, we examined whether the PARP inhibitor 3-aminobenzamide (3AB) is effective in a rat model of treatment-resistant depression. Methods: Treatment-resis
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25

Gaspar, Diana Maria Diez. "A biophysical approach to Phospholipase A2 activity and inhibition by non-steroidal anti-inflammatory drugs." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/63806.

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26

Guo, Hui. "A study on the anti-inflammatory activity and mechanism of action of herba siegesbeckiae (Xixiancao)." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/533.

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To determine whether the three Siegesbeckia plants can all serve as the origins of HS, we compared their fingerprint chromatograms and inhibitory effects on inflammatory mediators. Chemical analyses showed that the three species have different profiles, although they have common peaks in their fingerprint chromatograms. Hierarchical cluster analysis (HCA) and principal component analysis (PCA) of the common peaks demonstrated that all samples of the three species tend to be species-dependently grouped and separated. Ten components contributing to the species discrimination were identified, of
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27

Man, Francis Alexandre Wei Ming. "Investigating the anti-inflammatory activity of a fragment of Chaperonin 60.1 derived from Mycobacterium tuberculosis." Thesis, King's College London (University of London), 2016. http://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-antiinammatory-activity-of-a-fragment-of-chaperonin-601-derived-from-mycobacterium-tuberculosis(0877ad17-bfb2-4223-a0a4-904589c39bf9).html.

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Chaperonin 60.1 (Cpn60.1) from Mycobacterium tuberculosis is a protein that has evolved from the traditional role of chaperone in protein folding to a role in extracellular signalling. While non-essential to the growth and survival of the bacteria, Cpn60.1 is essential to the formation of granuloma in tuberculosis [150]. Cpn60.1 has been shown to induce cytokine production in human monocytes [201], but also to prevent leukocyte migration in murine models of allergic lung inflammation [300]. Peptide 4, a fragment of Cpn60.1, has been shown to be responsible for the cytokineinducing activity of
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28

Gaspar, Diana Maria Diez. "A biophysical approach to Phospholipase A2 activity and inhibition by non-steroidal anti-inflammatory drugs." Tese, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/63806.

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29

Grando, Rogério 1985. "Pterodon pubescens Benth. : avaliação da atividade anti-inflamatória e antinociceptiva do extrato aquoso e atividade anti-artrite reumatoide do extrato diclorometano em modelos animais." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317633.

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Orientador: Mary Ann Foglio<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T12:01:31Z (GMT). No. of bitstreams: 1 Grando_Rogerio_M.pdf: 3627366 bytes, checksum: 922ac0cfe7471065c3f3722c5e2b97bf (MD5) Previous issue date: 2013<br>Resumo: O uso de plantas medicinais é uma prática comum na medicina popular, entretanto, seu uso indiscriminado pode trazer sérios danos à saúde. Portanto é de fundamental importância estudos que comprovem a eficácia, segurança e qualidade de uma espécie vegetal. Estudos conduzidos pelo no
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30

Fang, Yi-Ting, and 方怡婷. "Isolation conditions immunomodulatory and anti-inflammatory activites of rice bran feruloylated oligosaccharides." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/78511314853398292418.

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碩士<br>中華醫事科技大學<br>生物科技研究所<br>96<br>This study was to investigate the optimization conditions of feruloylated oligosaccharides preparation from rice bran by acid hydrolysis and to evaluate the immunomodulatory function of feruloylated oligosaccharides. To obtain the optimization conditions of feruloylated oligosaccharides preparation, response surface methodology (RSM) was introduced in this study. The optimal condition of 193 mM of TFA and 1.36 h of hydrolysis time was derived from canonical analysis. 2.2% of feruloylated oligosaccharides recovery was verified from predicted optimal condition
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31

Cooper, William. "Immunomodulatory effects of lactic acid bacteria on human intestinal epithelial cells and macrophages in the context of a pro-inflammatory challenge." Thesis, 2009. http://hdl.handle.net/10155/69.

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Immunomodulatory effects of lactic acid bacteria vary with strain and may vary with growth phase and medium. The ability of different lactobacilli strains (Lactobacillus helveticus R0052, L. rhamnosus R0011, L. rhamnosus GG) at different growth phases to modulate macrophage and intestinal epithelial cell cytokine production following a pro-inflammatory challenge was examined. Modulation of cytokine production by human macrophage cell lines (U-937) and intestinal epithelial cells (HT-29) induced by Tumor Necrosis Factor α was assayed by ELISA for interleukin-8 (IL-8). Granulocyte-macrophage col
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32

Tsao, Yao-Ｗei, and 曹耀巍. "A Novel Fungal Immunomodulatory Protein (GFP) from Grifola frondosa Enhances Th1 Immune Response and Anti-Tumor Activity in Mice." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/15471109601825679090.

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碩士<br>國立臺灣大學<br>園藝學研究所<br>100<br>Grifola frondosa is a Japanese traditional medicine and is phylogenetically close to a Chinese traditional medicine, Grifola umbellate. A novel immunomodulatory protein (G. frondosa protein, GFP) was purified form the fruiting bodies of G. frondosa. Size-exclusion chromatography and SDS-PAGE electrophoresis results indicated that the native GFP (83 kDa) was a dimer consisted of 41.1 kDa subunits and was not a glycoprotein. By the analysis of N-terminal amino acid sequence, we discovered that the subunits of GFP were different proteins. Therefore, we conclude
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33

Fernando, Susil Francis. "Investigation into two Australian medicinal plants Viola odorata and Euphorbia peplus for anticancer agents." Thesis, 2002. https://vuir.vu.edu.au/30249/.

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In the absence of a clear understanding of the aetiology of diseases and measurable parameters for the attributes of drugs described in the traditional systems of medicine, an approach encompassing a broad spectrum of biological activities on the whole body that may be ascribable to the attributes of the drugs and aetiology of a disease described in the traditional medical systems such as Ayurveda, taken to investigate putative anticancer plants, is presented. Extracts of the putative anticancer plants, Euphorbia peplus L. (petty spurge) and Viola odorata L. (sweet violet), which grow i
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34

Lin, Chia-Ying, and 林佳瑩. "Immunomodulatory and anti-inflammatory effects of camellia oil." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/46330194402748150904.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>105<br>The beneficial effects of Camellia oil (Camellia oleifera Abel.) on gastrointestinal tract have been recognized; however, the effect of camellia oil on immunomodulatory has not been studied. Therefore, the aim of this study was to evaluate the immunomodulatory effects of camellia oil using an in vitro and in vivo models. In vitro, the results showed that RAW 264.7 macrophage treated with camellia oil (more than 25 µg/mL) significantly increased the phagocytosis activity, and reduced the productions of inflammatory cytokines, including NO, IFN-γ and IL-6.
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35

Wen-Hsien and 王文賢. "Anti-inflammatory and Stability of Fungal Immunomodulatory Protein." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/37136678341685782221.

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碩士<br>中山醫學大學<br>醫學分子毒理學研究所<br>93<br>Two fungal immunomodulatory proteins (FIPs) have been isolated, purified from the edible mushroom Ganoderma tsugae and Flammulina velutipes and designated FIP-gts and FIP-fve, respectively. They have immunomodulatory activities and 60% identical amino acid sequence. Using FIP-gts conjugated with FITC to trace the influence of FIP-gts in human peripheral blood mononuclear cells (HPBMCs), we found that most fluorescence located on cytoplasm in lymphocytes. Analyzing the cytokines induced by FIP-gts or FIP-fve in HPBMCs, pre-treatment of EDTA was inhibited the
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Lin, Chin-chun, and 林錦均. "Immunomodulatory and Anti-inflammatory effects of Agaricus blazei Polysaccharides." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/82108764091277796751.

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碩士<br>中臺科技大學<br>醫學生物科技研究所<br>100<br>Agaricusl blazei Murill has been traditionally used as a health food source in Brazil for the prevention of cancer, diabetes, hyperlipidaemia, arteriosclerosis and chronic hepatitis. In this study, BALB/c mice were fed with A. blazei polysaccharides at different time points to investigate the anti-inflammatory action and the immunomodulatory effect. When mice were administrated A. blazei polysaccharides for a period of time and then injected LPS into mice, The Trem-1HI expression on macrophages is inhibited. The expressions of CD40HI and CD8αHI markers on DC
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37

Huang, An-Cheng, and 黃安正. "Synthesis and anti-inflammatory activity of acrophyllidine." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/43375352432682700091.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>81<br>In order to examine the biologic activities of Furo[2,3-b]- quinolin-4-one derivatives , a synthesic approach to the structure reported for Acrophyllidine by F. N. Lahey and M. Mc.Camish was carried out . The spectral data of the syntheic product were identical with those described previouly for Acrophyllidine,thus, the original structure of this natural alkaloid should be correct. The synthetic compounds were evaluated its activity by mast
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38

Zhang, Jingwen, Anaïs Pitto-Barry, Lijun Shang, and Nicolas P. E. Barry. "Anti-inflammatory activity of electron-deficient organometallics." 2017. http://hdl.handle.net/10454/13760.

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Yes<br>We report an evaluation of the cytotoxicity of a series of electron-deficient (16-electron) half-sandwich precious metal complexes of ruthenium, osmium and iridium ([Os/Ru(η6-pcymene)( 1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1/2), [Ir(η5-pentamethylcyclopentadiene)(1,2-dicarba-closo-dodecarborane- 1,2-dithiolato)] (3), [Os/Ru(η6-p-cymene)(benzene-1, 2-dithiolato)] (4/5) and [Ir(η5-pentamethylcyclopentadiene) (benzene-1,2-dithiolato)] (6)) towards RAW 264.7 murine macrophages and MRC-5 fibroblast cells. Complexes 3 and 6 were found to be non-cytotoxic. The anti-inflamm
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39

Yu, Kun-Lung, and 游昆龍. "Synthesis and Anti-inflammatory Activity of Chalcone Derivatives." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/08179229109419278859.

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碩士<br>高雄醫學大學<br>藥學研究所<br>88<br>For a continued study of structure-activity relationship of various chalcone derivatives designed as anti-inflammatory agents, we have synthesized a series of new chalcone derivatives and related compounds, 1-11, and studied on their anti-inflammatory effects. All the chalcones and related compounds were prepared by Claisen- Schmidt Condensation of appropriate acetophenones with appropriate aromatic aldehydes. Alkoxylchalcones were prepared by appropriate dihydroxylchalcones and alkyl iodides. One flavone was synthesized by appropriate acetophenone wit
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Cheng, Shyh-Bin, and 鄭世斌. "Synthesis and anti-inflammatory activity of leflunomide analogs." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/36997375275766386658.

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碩士<br>國防醫學院<br>藥學研究所<br>91<br>Leflunomide is one of the promising disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis. It is considered the best lead for further optimization due to the hepatic toxicity. Two series of leflunomide analogs, N-(Substituted phenyl)-4-carboxamidyl-5-methylpyrazoles ( 4a∼4r ) and 2-amino-3-nitrilo-4,6-(substituted diaryl)-pyrans ( 11a∼11r ), were evaluated in vivo and in vitro bioactivities. The target compounds were subjected to the preliminary screenings of inhibiting LPS-induced inflammation and assay of cell viability on ma
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Pillay, Candice Claudia Natasha. "Anti-inflammatory and anti-bacterial activity of South African Erythrina species." Thesis, 2000. http://hdl.handle.net/10413/10248.

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An investigation was undertaken to determine whether Erythrina species indigenous to South Africa contained the same type of compounds as Erythrina species not found in South Africa and to determine whether they displayed any anti-inflammatory and antibacterial activity. Phytochemical analysis was conducted using thin layer chromatography. A great similarity was found in the leaf profiles of the species being studied. The leaf and bark extracts of E. caffra and E. lysistemon appear to have similar profiles when viewed under normal light and ultraviolet light, (254 and 366 nm). These two specie
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Morais, Adriano José Sousa. "Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity." Master's thesis, 2020. http://hdl.handle.net/10348/9937.

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Dissertação de Mestrado em Engenharia Biomédica<br>This study is focused on three main flavonoids compounds: Kaempferol, which is isolated from several natural plants, it is a polyphenol belonging to the subgroup of flavonoids, it exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities; Quercetin which is a polyphenolic flavonoid with potential chemopreventive activity, ubiquitous in plant food sources and a major bioflavonoid in the human diet, it also produces anti-inflammatory and anti-allergy effects mediated through t
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Tang, Ching-Yin, and 唐菁吟. "Screening flavonoid-rich vegetables and fruits to evaluate their immunomodulatory and anti-inflammatory functions." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/77935667205514534952.

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碩士<br>國立中興大學<br>食品科學系<br>92<br>Abstract The purpose of this study was to screen flavonoid-rich vegetables and fruits to evaluate their immunomodulatory and anti-inflammatory functions. In the first part of this study, crude juices of thirteen kinds of commonly used vegetables and fruits, including sweet peppers ( varieties of green, red and yellow colors), ceylon spinach, onions ( common and purple color І and П), strawberry, oriental plum, mulberry, loquat, bitter melon and beet were obtained to determine their flavonoid content and to investigate their immunomodu
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庄司, 徹., and Toru SHOJI. "Biotechnological Research on Anti-inflammatory Activity of Siglec-9." Thesis, 2014. http://hdl.handle.net/2237/20268.

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Lin, Cheng-Hsiu, and 林正修. "Anti-inflammatory Activity of Peroxyauraptenol Extracted from Cnidium monnieri." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/79124925394166460957.

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碩士<br>國立宜蘭大學<br>生物技術與動物科學系生物技術碩士班<br>101<br>Cnidium monnieri Cuss. is not only a traditional Chinese herb, but also an economically important agricultural product via artificial planting. Five compounds were isolated from the ethanol extract of seeds of C.monnieri including osthole, imperatorin, xanthotoxin, isopimpinellin, and peroxyauraptenol. The structure between osthole and peroxyauraptenol are similar, and osthole has been reported to exhibit various biological activities, but the function of peroxyauraptenol has not been reported, and hence, in this study we investigated the effect of p
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Lai, Hsin-Yuan, and 賴欣沅. "Study on the Anti-inflammatory Activity of Euphorbia neriifolia." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/19291942724680255403.

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碩士<br>國立宜蘭大學<br>生物資源學院碩士在職專班<br>101<br>Euphorbia neriifolia is a shrubby, erect, branched, fleshy, cactus-like plant, has a wide range of pharmacological effects, including anti-inflammation and antioxidant activity; however, the mechanism is unclear yet. In this study we examined the potential anti-inflammatory mechanism of extracts of Euphorbia neriifolia in murine macrophages cell lines RAW 264.7. The n-Hexane extracts of Euphorbia neriifolia reduced lipopolysaccharide-induced increase in tumor necrosis factor α and interleukin-6 secretion and also significantly reduced inducible nitric oxi
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Nadworny, Patricia L. "Biological activity of nanostructured silver." Phd thesis, 2010. http://hdl.handle.net/10048/910.

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Thesis (Ph.D.)--University of Alberta, 2010.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Chemical and Materials Engineering, Medical Sciences - Biomedical Engineering. Title from pdf file main screen (viewed on January 30, 2010). Includes bibliographical references.
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Shale, Thato Lucy. "Anti-bacterial and anti-inflammatory activity of medicinal plants used traditionally in Lesotho." Thesis, 2003. http://hdl.handle.net/10413/10191.

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A significant potion of the population in Lesotho relies on traditional medicine to meet its health care requirements. Traditional healers and herbalists were interviewed from Qacha's Nek (Highlands) and Mohale's Hoek (Lowlands) districts in Lesotho on plants used by the Basotho in traditional remedies. Fifteen plants were reported to be used for bacterial infections while thirteen plants were used for diseases associated with inflammation . Plant roots were most often used to make water extracts. Mainly high altitude plants are used with lowland healers obtaining most of their plant material
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Chang, Wen-Ya, and 張文雅. "The evaluation of anti- Pityrosporum ovale and anti-inflammatory activity of essential oils." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/68646353290165316236.

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碩士<br>嘉南藥理科技大學<br>化妝品科技研究所<br>95<br>Dandruff is mainly due to speedy skin turnover which results in epidermal cells hyper proliferation and flaking off. When excessively sebum secrets, the number of Pityrosporum ovale, P. ovale, which resides in sebaceous glands, increases a lot. Dandruff can be controlled by antibiotics at present, but it may easily result in antibiotic drug resistance and skin inflammation. The objective of this study is to investigate the feasibility of essential oils added in anti-dandruff products. In the first part of this study, the antimicrobial activity of P. ovale wa
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Wang, Han Hsiang, and 王翰翔. "The Structure-Activity Relationships Study of Anti-inflammatory Anthranilate Derivatives." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/72250686191916459831.

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碩士<br>長庚大學<br>中醫學系天然藥物<br>98<br>In present study, fifty-four anthranilate derivatives were synthesized and evaluated their inhibitory effects on neutrophils elastase release and superoxide anion generation induced by FMLP. Among them, WHH 34 is more potent than the lead compounds (DXM-RX78 and DSM-RX116) with IC50 value of 0.06 μM. Compounds WHH 50, 51 and 52 shown selectively inhibitory effects on neutrophils elastase release with IC50 values of 0.046, 0.049 and 0.038 μM respectively. The analysis of structure-activity relationships revealed that extending the carbon chain (methyl to butyl) o
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