Relevant bibliographies by topics / Immunophilins / Dissertations / Theses
To see the other types of publications on this topic, follow the link: Immunophilins.

Dissertations / Theses on the topic 'Immunophilins'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 27 dissertations / theses for your research on the topic 'Immunophilins.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Dornan, Jacqueline. "Immunophilins : an investigation into function and structure." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/22159.

Full text
Abstract:
The work described in this thesis focused on the over-expression, purification, biochemical characterisation, crystallisation and 3-D structure determination of three members of the immunophilin family. The overall goal of the project was to use biochemical and structural information derived from these studies to assist in the elucidation of the various roles played by these proteins in diverse systems. Cycophilin 3. Cloning and expression of eleven cyclophilin homologues from the free-living nematode <i>Caenorhabditis elegans </i>(<i>C. elegans</i>) has recently been reported. Cyclophilin 3 (
APA, Harvard, Vancouver, ISO, and other styles
2

Morgan, Gloria Yvonne. "The expression of immunophilins in cells and organelles." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282145.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

McKenzie, Neil Iain. "The immunophilins as drug targets : development of novel fluorescence assays." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17961.

Full text
Abstract:
The immunophilins are a superfamily of proteins comprising the cyclophilins, the FKBPs and the parvulin sub-families. Members are present ubiquitously in plant and animal cells, acting as both prolyl-isomerases and signalling proteins. Some also have chaperone activity. The prolyl isomerase function of the immunophilins has been identified as being central to progression of a large number of diseases, making them tempting drug targets. Whilst there are several assays which can be used to identify inhibitors of the prolyl isomerase function, they are hampered by one or more problems: multistep
APA, Harvard, Vancouver, ISO, and other styles
4

McCann, Fiona Elizabeth. "Studies on novel immunophilins and the effects of immunosuppressant drugs on neurons." Thesis, University of Kent, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246593.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Davies, Todd Howard. "Regulation of glucocorticoid receptor function by associated TPR-domain proteins." Connect to full-text via OhioLINK ETD Center, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1098292002.

Full text
Abstract:
Thesis (Ph. D.)--Medical College of Ohio, 2003.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences." Major advisor: Edwin Sanchez. Includes abstract. Document formatted into pages: iv, 126 p. Title from title page of PDF document. Includes bibliographical references (p. 100-124).
APA, Harvard, Vancouver, ISO, and other styles
6

Davies, Todd Howard. "Regulation of Glucocorticoid Receptor Function by TPR-domain Proteins." University of Toledo Health Science Campus / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=mco1098292002.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Cluning, Carmel. "Steroid receptor-associated immunophilins : influence of targeted knockdown and altered expression on receptor signalling." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0215.

Full text
Abstract:
[Truncated abstract] Steroid receptors belong to the superfamily of nuclear receptors, and include the androgen receptor (AR), estrogen receptors (ER[alpha] and ER[beta], glucocorticoid receptor (GR), mineralocorticoid receptor (MR), and the progesterone receptors (PRA and PRB). Before binding ligand, the receptor undergoes biochemical and structural modifications through a series of interactions with molecular chaperones and cochaperones all within a receptor heterocomplex. The mature receptor complexes with the major chaperone Hsp90, the stabilising cochaperone p23, and one member of a group
APA, Harvard, Vancouver, ISO, and other styles
8

Warrier, Manya. "Role of FKBP51 and FKBP52 in Glucocorticoid Receptor Regulated Metabolism." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1223923687.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Sandhu, Khushwant Singh. "Identification and molecular characterization of the putative immunophilins (IMMs) in the oilseed rape pathogens Leptosphaeria maculans, Leptosphaeria biglobosa, and Plasmodiophora brassicae." Doctoral thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-259691.

Full text
Abstract:
Oilseed rape is largely infected by several phytopathogens and two most economical important diseases are blackleg caused by fungus species complex Leptosphaeria maculans and L. biglobosa and clubroot caused by protist P. brassicae. The sequenced genomes of these phytopathogens provide opportunity to uncover various aspects related to disease infection, host pathogen interactions, plant disease resistance, and evolution of pathogens. Considering these we focused on one of the most conserved family called immunophilins (IMMs) in these genomes. IMMs are comprised of three structurally unrelated
APA, Harvard, Vancouver, ISO, and other styles
10

Somarelli, Jason Andrew. "The Role of Splicing Factors and Small Nuclear RNAS in Spliceosomal Formation." FIU Digital Commons, 2009. http://digitalcommons.fiu.edu/etd/83.

Full text
Abstract:
Protein coding genes are comprised of protein-coding exons and non-protein-coding introns. The process of splicing involves removal of the introns and joining of the exons to form a mature messenger RNA, which subsequently undergoes translation into polypeptide. The spliceosome is a large, RNA/protein assembly of five small nuclear RNAs as well as over 300 proteins, which catalyzes intron removal and exon ligation. The selection of specific exons for inclusion in the mature messenger RNA is spatio-temporally regulated and results in production of an enormous diversity of polypeptides from a si
APA, Harvard, Vancouver, ISO, and other styles
11

Kontopidis, George A. "Immunophilin ligand design." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/22386.

Full text
Abstract:
The general aim of the project is predict and select small molecule ligands which may bind to 3D protein templates. Proteins from the Immunophilin family were used. The putative ligands were selected by two different methods, by structure similarity and using the docking program LIDAEUS, which was developed in house by Dr. P. Taylor. Twenty nine small molecules were selected from a small molecule database and were tested with a fluorescence assay, a PPIase assay and x-ray crystallography for binding activity. Six new ligands have been discovered which bind to Cyp-A. In this work the IC<sub>50<
APA, Harvard, Vancouver, ISO, and other styles
12

Yuande, Y. "Structural studies of immunophilin-ligand complexes." Thesis, University of Edinburgh, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664185.

Full text
Abstract:
The work described in this thesis used crystallographic and biochemical methods to study the complex of immunophins (humans Cyclophilin A (hCypA) and FK506 binding protein (FKBP)) with a series of chemically synthesised ligands. HCypA is the cytosolic receptor of the immunosuppressant Cyclosporin A (CsA), and FKBP is the receptor for the immunosuppressant FK506. Both hCypA and FKBP possess peptidyl-prolyl isomerization (PPIase) enzymatic activity. In this project hCypA was produced and characterised in house. SDS page electrophoresis, mass spectrometry and PPIase enzymatic assays were used to
APA, Harvard, Vancouver, ISO, and other styles
13

Patterson, Alan F. "Biophysical and crystallographic studies of immunophilin-ligand complexes." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/15599.

Full text
Abstract:
The work in this thesis describes the cloning, expression purification and characterisation of human CypA and FKBP12 proteins. Various biophysical techniques were used to study and characterise the interactions of different ligands with these target proteins. Vectors containing the genes encoding each of these, for expression of both wild-type protein and protein with a hexa-histidine tag, have been cloned for both hCypA and hFKBP12. Crystals of hCypA have been grown, and the structures, in complex with a range of small molecules including dipeptides, and dimedone derived ligands, have been so
APA, Harvard, Vancouver, ISO, and other styles
14

Lane-Guermonprez, Lydie. "Stress nitro-oxydatif et immunophilines dans le contrôle du métabolisme cholinergique." Paris 11, 2002. http://www.theses.fr/2002PA112112.

Full text
Abstract:
Le monoxyde d'azote est un modulateur physiologique de l'activité nerveuse qui peut se combiner avec l'ion superoxyde pour former du peroxynitrite, un radical oxydant et nitrant. La calcineurine est la seule phosphatase enrichie dans les neurones, modulée par le calcium et perturbée par certains stress oxydatifs. Elle est impliquée dans les phénomènes de plasticité synaptique et de régénération axonale. Les principaux inhibiteurs de cette phosphatase sont des immunosuppresseurs, le FK506 et la cyclosporine (CsA). Ces agents ont des effets paradoxaux in vivo, puisqu'ils sont à la fois neurotoxi
APA, Harvard, Vancouver, ISO, and other styles
15

Guimiot, Fabien. "Etude fonctionnelle de deux immunophilines, Fkbp25 et Fkbp36 dans le développement neuronal." Paris 7, 2003. http://www.theses.fr/2003PA077217.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Chopard, Christophe. "Régulations de la sécrétion et de l’activité biologique de la protéine Tat du VIH-1 : rôles de la palmitoylation et de Gag." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20089/document.

Full text
Abstract:
La protéine du VIH-1 est une protéine essentielle à la transcription et à la réplication du virus. Elle a donc un rôle crucial dans la cellule infectée. On sait qu'une partie de la Tat cellulaire peut être sécrétée, malgré l'absence de séquence signal. En effet, les 2/3 de la Tat cellulaire sont exportés par la cellule T-primaire infectée. Le mécanisme de sécrétion de Tat est non conventionnel et se produit directement à travers la membrane plasmique où Tat est recrutée grâce à sa très forte affinité pour le phosphatidylinositol(4,5)-biphosphate ou PI(4,5)P2 qui est exclusivement localisé à ce
APA, Harvard, Vancouver, ISO, and other styles
17

Rivière, Sylvie. "Caracterisations biochimiques et fonctionnelles d'une immunophiline, la fkbp25, et d'une cytokine, le mif." Paris 11, 1995. http://www.theses.fr/1995PA112133.

Full text
Abstract:
Cette these est consacree a l'etude des fonctions de deux proteines: la fkbp25, qui est une immunophiline, et le mif, une cytokine. Les immunophilines sont les proteines acceptrices, intracellulaires pour la plupart d'entre elles, des immunosuppresseurs que sont la cyclosporine a, le fk506 et la rapamycine. Ces derniers empechent l'activation du lymphocyte t, consecutive au contact avec un immunogene, et bloquent ainsi la reponse immunitaire. Nous avons, dans un premier temps, purifie la fkbp25 bovine a partir d'organes et obtenu un antiserum de lapin. Nous avons ainsi montre apres analyse par
APA, Harvard, Vancouver, ISO, and other styles
18

Le, Bihan Stéphane. "Role des immunophilines dans le mecanisme d'action des recepteurs des glucocorticosteroides et des progestagenes." Paris 11, 1996. http://www.theses.fr/1996PA11T025.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

Guimiot-Maloum, Ismahane. "Analyse fonctionnelle de deux gènes nouveaux, C61 et FKbp25, identifiés par comparaison de transcriptomes : leur implications dans le développement cortical." Paris 6, 2005. http://www.theses.fr/2005PA066309.

Full text
APA, Harvard, Vancouver, ISO, and other styles
20

Kamah, Amina. "Identification et caractérisation des modifications post-traductionnelles de la protéine TAU : implication dans le processus d'agrégation." Thesis, Lille 1, 2015. http://www.theses.fr/2015LIL10049.

Full text
Abstract:
Les démences séniles sont caractérisées, au niveau moléculaire, par l’agrégation de quelquesprotéines-clés. On peut donner comme exemple l’α-synucléine, dans la maladie de Parkinson,ou le peptide β-amyloïde et la protéine Tau, dans la maladie d’Alzheimer. Le mauvaisrepliement de ces protéines est souvent évoqué, même si elles n’adoptent pas une structurestable lorsqu’elles sont isolées en solution. La protéine Tau est une protéine neuronaleappartenant à la famille des protéines MAP (protéines associées aux microtubules). Saprincipale fonction est de stimuler la polymérisation de la tubuline en
APA, Harvard, Vancouver, ISO, and other styles
21

Blackburn, Elizabeth Anne. "Biophysical studies of protein-ligand interactions and the discovery of FKBP12 inhibitors." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/6504.

Full text
Abstract:
The principal aim of this study was to discover, through virtual screening, new nonimmunosuppressive inhibitors for the human immunophilin FKBP12, a target of the immunosuppressant drugs rapamycin and FK506. The enzyme acts as peptidyl-prolyl isomerase catalysing protein folding in the cell. Structurally similar isomerase domains are important for molecular recognition in multi-domain chaperone proteins. FKBP inhibitors have been shown to have protective effects against nerve damage and are therefore interesting targets for the treatment of neurodegenerative diseases. Virtual screening has bee
APA, Harvard, Vancouver, ISO, and other styles
22

Moore, Stephen. "Characterisation of a novel immunophilin-like gene, repressed by low doses of ionising radiation; identification of interacting proteins." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272344.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Strunz, Patrick-Pascal Holger [Verfasser], Petra [Gutachter] Eder-Negrin, Erhard [Gutachter] Wischmeyer, and Brenda [Gutachter] Gerull. "Interaktion von TRPC-Ionenkanälen mit dem Immunophilin FKBP52 / Patrick-Pascal Holger Strunz ; Gutachter: Petra Eder-Negrin, Erhard Wischmeyer, Brenda Gerull." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1210862336/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Edvardsson, Anna. "Peptidyl-prolyl cis-trans Isomerases in the Chloroplast Thylakoid Lumen." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med983s.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Strunz, Patrick-Pascal Holger. "Interaktion von TRPC-Ionenkanälen mit dem Immunophilin FKBP52." Doctoral thesis, 2020. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-204298.

Full text
Abstract:
Einleitung: TRPC-Kanäle spielen eine wichtige Rolle in der Pathologie der Herzinsuffizienz und kardialen Hypertrophie. Diese Effekte werden unter anderem über den Calcineurin-NFAT-Signalweg vermittelt. Ein wichtiger Interaktionspartner und Regulator von TRPC-Kanälen ist das Protein FKBP52. Mittels eines Yeast Two-Hybrid Systems wurde in einer kardialen cDNA library eine Interaktion zwischen einem C-terminalen Fragment von TRPC3 (AS 742-848), welches außerhalb der bekannten FKBP-Bindungsdomäne (AS 703-714) liegt, und FKBP52 beobachtet. Da dies eine weitere Bindungsstelle in FKBP52 vermuten ließ
APA, Harvard, Vancouver, ISO, and other styles
26

Germain, Marie-Anne. "Découverte de nouvelles interactions entre le virus de l'Hépatite C et l'hôte par une approche combinée de Spectrométrie de Masse et de Génomique Fonctionnelle." Thèse, 2012. http://hdl.handle.net/1866/10026.

Full text
Abstract:
La réplication et l’assemblage du virus de l’hépatite C (VHC) sont régulés finement dans le temps et l’espace par les interactions protéiques entre le virus avec l’hôte. La compréhension de la biologie du virus ainsi que sa pathogénicité passe par les connaissances relatives aux interactions virus/hôte. Afin d’identifier ces interactions, nous avons exploité une approche d’immunoprécipitation (IP) couplée à une détection par spectrométrie de masse (MS), pour ensuite évaluer le rôle des protéines identifiées dans le cycle viral par une technique de silençage génique. Les p
APA, Harvard, Vancouver, ISO, and other styles
27

Hui, Kelvin Kai-Wan. "Analysis of Mitochondrial Signaling in the Regulation of Programmed Cell Death." Thesis, 2011. http://hdl.handle.net/1807/29750.

Full text
Abstract:
The involvement of mitochondrial signaling in mammalian PCD regulation has been examined extensively via biochemical analyses and cellular studies in vitro. However there still exist considerable gaps in our knowledge regarding its contribution in specific tissues and cell types during mammalian development in vivo. In addition, given the numerous pathologic conditions associated with aberrant PCD, modulation of this signaling process represents an attractive target for therapeutic intervention. In this thesis I have therefore examined the regulation of mitochondrion-mediated PCD signaling as
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Immunophilins' for other source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography