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Dissertations / Theses on the topic 'Immunosuppressants such as corticosteroids'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Cattaneo, Dario. "Therapeutic drug monitoring of novel immunosuppressants." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424822.

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Therapeutic drug monitoring is primarily undertaken for narrow therapeutic inde:drugs, such as immunosuppressants. These drugs have reduced the incidence of acute rejection and improved allograft survival. However, due to their narrow therapeutic index, small variations in blood levels may result in inadequate levels of immunosuppression or toxic drug concentrations. To overcome these problems individual dose regimen based-on phannacokinetic monitoring has been proposed in the past years. Indeed, several studies have previously documented a significant association between cyclosporine whole bl

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2

Choice, Edward G. "Liposomal immunosuppressants for the management of organ transplantation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0032/NQ27119.pdf.

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3

陳錦源 and Kam-yuen Chan. "Design and synthesis of bucillamine analogs as immunosuppressants." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31213893.

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4

Chan, Kam-yuen. "Design and synthesis of bucillamine analogs as immunosuppressants /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18597919.

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5

Smith, Kevin J. "Studies directed towards the synthesis of FK-506." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239606.

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6

French, Martin Thomas. "Fluorescence immunoassay for cyclosporin A." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/33279.

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Monodansylcadavarine (MDC) was used to synthesise a fluorescent derivative of cyclosporin A and the product of the reaction was isolated by preparative thin layer chromatography (TLC) and purified by high performance liquid chromatography (HPLC). The fluorescent derivative was shown to bind with a polyclonal antibody to cyclosporin A by submitting the derivative for analysis by cyclosporin radioimmunoassay (RIA). However this derivative did not bind with a monoclonal antibody used in a RIA specific for the parent compound. To achieve this fluorescent derivatives were synthesised using cyclospo

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7

Norman, Joanne. "Synthetic studies on the C10-C17 fragment of rapamycin." Thesis, University of Cambridge, 1994. https://www.repository.cam.ac.uk/handle/1810/272766.

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8

Cairns, Jasmin. "Immunosuppressants and the renal transplant recipient : factors affecting adherence." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/immunosuppressants-and-the-renal-transplant-recipient-factors-affecting-adherence(c9be2ef8-6b8c-45ee-9061-057c93cbab49).html.

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In renal transplantation, immunosuppressants are prescribed to patients to prevent graft loss. Although the extent of adherence required for such treatment to prevent graft loss has not been determined, it is thought to be high. Despite this, research suggests adherence rates for renal transplant recipients to be only between 50% and 95%. Considering the impact of graft loss on the renal patient, the national healthcare budget and on the limited resource of donor organs, it is important to identify and understand factors that contribute to nonadherence, and thereafter to address those that are

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9

Lundin, Anders. "Corticosteroids in Lumbar Disc Surgery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6126.

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10

Notari, Lorella. "Exogenous corticosteroids and dog behaviour." Thesis, University of Lincoln, 2016. http://eprints.lincoln.ac.uk/23697/.

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Arousal and distress are considered important factors when dogs show problematic behaviours and the crucial role of hormones and neurotransmitters involved in stress responses is widely recognized. Corticosteroids are important players in stress responses and, along with other hormones and neurotransmitters, contribute to the onset of both physiological and behavioural changes that can be either normal and adaptive or excessive and maladaptive depending on several factors. A literature review revealed that exogenous corticosteroids have been reported to change behaviour in human beings and lab

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11

Gill, Diana J. "The effect of immunosuppressants in a mouse model of glomerulonephritis." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU070843.

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This study compared the effect of various immunosuppressive therapies on the development of lupus nephritis using a murine model of SLE, the MRL lpr/lpr mouse. The agents investigated were cyclosporin A (CsA), FK506, rapamycin and mycophenolate mofetil (MM). Female MRL lpr/lpr mice at 12 weeks old were treated with CsA (40mg/kg/day p.o.), FK506 (2.5mg/kg/3 times/week or/day s.c.), rapamycin (1.5mg/kg.day s.c.), MM (50mg/kg/2 times daily p.o.) or vehicle controls. These groups were compared with untreated MRL lpr/lpr and also untreated MRL +/+ mice which do not develop this autoimmune disease.

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12

Ren, Aaron G. "Immunosuppressants used in the conditioning regimens for hematopoietic stem cell transplantation /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/7957.

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13

Stagg, Deborah J. "The targeting of corticosteroids to inflamed tissues." Thesis, Aston University, 1994. http://publications.aston.ac.uk/11049/.

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This project, following the line of investigation started by other workers, was designed to study the use of microspheres to deliver corticosteroids to inflamed tissues by both the oral and intravenous routes. Hydrocortisone (HC)-loaded albumin microspheres were prepared by three different methods, by direct incorporation of HC within the particles, by indirect incorporation of HC by the enzymatic conversion of hydrocortisone-21-phosphate (H-21-P) to HC within the particles, and by the adsorption of HC onto the surface. HC was also loaded with PLA microspheres. The level of corticosteriod load

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14

Wang, Xin. "Probing the molecular events in T cell activation and proliferation with immunosuppressants." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0007/NQ42295.pdf.

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15

Ellis, Jonathan. "Examining a role for histone deacetylase inhibitors as immunosuppressants in organ transplantation." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6987/.

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Current transplant immunosuppression regimens have numerous limitations. Recent evidence suggests histone deacetylase inhibitors (HDACis) may represent a class of drug with immunosuppressive properties. This study initially assessed a panel of experimental and established HDACis, identifying a novel HDAC6-specific inhibitor (KA1010) to compare with cyclosporin and the pan-HDACi suberoylanilide hydroxamic acid in models of alloreactivity. Proliferation and MLR-based assays were used to determine the immunosuppressive effect of compounds, and a murine model of allogeneic skin transplantation was

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16

Butler, Janet Ann. "Prevalence and psychosocial correlates of non-adherence to immunosuppressants in renal transplant recipients." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273830.

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17

Bassiri, Gharb Bahar. "Effectiveness of Topical Immunosuppressants in Prevention and Treatment of Rejection in Face Allotransplantation." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3425271.

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Background- The use of topical immunosuppressants has been anecdotally reported for the treatment of rejection in Vascularized Composite Allotransplantation (VCA). The aim of the present study was to evaluate the effectiveness of topical Tacrolimus and Clobetasol in the prevention and treatment of rejection. Methods- Seventy-six hemiface allotransplants were performed, between ACI (RT1a) donors and LEW (RT1l) recipients. The animals were divided in 11 groups. With the exception of isografts (group 1) and allografts (group 2), the animals received systemic induction with Cyclosporine A and ant

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18

Sauvage, Magdalena. "Corticosteroids and cognitive function : behavioural and neuroanatomical studies." Thesis, Open University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247040.

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19

Ullrich, René, Martin Hofrichter, Marzena Poraj-Kobielska, et al. "Side chain removal from corticosteroids by unspecific peroxygenase." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-235595.

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Two unspecific peroxygenases (UPO, EC 1.11.2.1) from the basidiomycetous fungi Marasmius rotula and Marasmius wettsteinii oxidized steroids with hydroxyacetyl and hydroxyl functionalities at C17 - such as cortisone, Reichstein's substance S and prednisone - via stepwise oxygenation and final fission of the side chain. The sequential oxidation started with the hydroxylation of the terminal carbon (C21) leading to a stable geminal alcohol (e.g. cortisone 21-gem-diol) and proceeded via a second oxygenation resulting in the corresponding α-ketocarboxylic acid (e.g. cortisone 21-oic acid). The lat

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20

Deeks, Josephine R. "The contribution of corticosteroids to the obese (obob) syndrome." Thesis, University of Ottawa (Canada), 1986. http://hdl.handle.net/10393/22461.

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21

Rauz, Saaeha. "Corticosteroids, 11Î²-hydroxysteroid dehydrogenase isozymes and the human eye." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269882.

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22

Llaudó, Vallmajor Inés. "P-Glycoprotein functional activity in peripheral blood lymphocytes. Role of immunosuppressants, pharmacogenomics and alloimmune response." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/134502.

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Both immunological and non immunological factors are involved in chronic allograft nephropathy such as donor specific alloreactivity, chronic inflammation and nephrotoxicity induced by anticalcineurinics. Different degrees of nephrotoxicity are related to immunosuppression and to the level of inhibition of the different transporter proteins such as MDR1, MRP1 and MRP2. Those proteins could be subjected to genetic inter-individual variability thus modifying pharmacokinetics parameters. Furthermore, optimal immunosuppressive dose could be predicted by genotype characterization of MDR1, MRP1 or M

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23

Wulff, Brian Charles. "Effects of Therapeutic Immunosuppressants on UVB Induced Inflammation and Skin Carcinogenesis in a Murine Model." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1227116356.

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24

Roberts, Caroline Jane. "Development and application of enzyme-linked immunosorbent assays for the detection of drugs in the equine." Thesis, University of Sunderland, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338354.

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25

Aghajafari, Fariba. "Multiple vs. single courses of antenatal corticosteroids for preterm birth." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58847.pdf.

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26

Edmonds, Marcia. "Inhaled corticosteroids in the emergency department treatment of acute asthma." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60425.pdf.

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27

Lundström, Staffan. "Corticosteroids in advanced cancer : epidemiology, symptom relief and patient experiences /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-131-9/.

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28

Turner, Roy Maxwell. "Cyclodextrins for oral liquid paediatric drug delivery : application to corticosteroids." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509400.

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29

Zollner, Ekkehard Werner Arthur. "Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on corticosteroids." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/95468.

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Thesis (PhD)-- Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Although the effect of inhaled corticosteroids (ICS) on the hypothalamic- pituitary-adrenal axis (HPA) has been regarded as a “benign physiological response”, a survey published in 2002 suggested that adrenal crisis is more common in asthmatic children on ICS than previously thought. Relying on clinical features to detect chronic adrenal insufficiency secondary to corticosteroids may not be wise, as these are non-specific and can therefore easily be missed. Accurate biochemical assessment of the whole axis to detect subcli

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30

Trahan, Richard Angellas. "Effects of Three Corticosteroids on Equine Articular Cocultures In Vitro." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/83501.

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The objective was to compare the effects of three corticosteroids at various equimolar concentrations on equine articular explant co-cultures in an inflammatory environment. Synovial and osteochondral explant co-cultures from 6 equine cadavers were exposed to IL-1β (10 ng/mL) and various concentrations (10-4, 10-7, or 10-10 M) of MPA, TA, IPA. Concentrations of PGE2, MMP-13, LDH, and GAG in media were determined at 48 and 96 hours. Results indicated wells with low concentrations of MPA (10-7 and 10-10 M at 48 and 96 hours), TA (10-7 M at 48 hours and 10-7 and 10-10 M at 48 and 96 hours), and I

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31

Banz, Kelly. "Calming the ocular storm : the effect of corticosteroids in inflammatory oedema." University of Western Australia. Faculty of Life and Physical Sciences, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0093.

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The primary aim of this research is to test the therapeutic potential of certain new generation corticosteroid drugs in order to develop safe and effective treatment for eye diseases that result in oedema, or swelling. The rising incidence of diabetes and the ageing population of developed countries mean that the prevalence of uveitis, diabetic retinopathy and age related macular degeneration will rise. Often, oedema is one of the reasons for vision loss. Corticosteroids are often used to reduce inflammation. Inflammation is one of several sources of oedema. Glucocorticoids, a class of cortic

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32

Chi, Ching-Chi. "Evidence-based assessment of the safety of topical corticosteroids in pregnancy." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504309.

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33

Mortimer, Kevin. "Adverse systemic effects of inhaled corticosteroids : a study of risk factors." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430646.

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34

Zvidzayi, Kudzayi Michael. "Investigation of the potency of topical corticosteroids using the vasoconstrictor assay." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/65279.

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35

Maung, Zor T. "A study of in vitro drug resistance ofleukaemic cells from patients with acute lymphoblastic leukaemia." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320828.

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36

Elderfield, Amber-Jayne. "Lipocortins in the central nervous system in multiple sclerosis and experimental allergic encephalomyelitis." Thesis, University of Bath, 1994. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385288.

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37

BERRETTONI, CHIARA. "Design, implementation and characterization of an optoelectronic platform for the detection of immunosuppressants in transplanted patients by means of a microfluidic optical chip." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1007099.

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The past few years have seen great interest and advances in scientific research on fluorescence-based microfluidic optical sensors for clinical/medical applications. In particular, the growing demand for point-of-care-testing (POCT) devices to be applied near the patient’s bed, has driven the development of simple to use, reliable and low cost microfluidic optical platforms. The main objective of the research project presented in this thesis is the development of a novel fluorescence-based microfluidic optical chip for the simultaneous analysis of different analytes and its integration into

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38

Feltis, Bryce Nathan 1975. "Eosinophils and eosinophilic chemokines in asthma and the effect of inhaled corticosteroids." Monash University, Dept. of Medicine, 2003. http://arrow.monash.edu.au/hdl/1959.1/5676.

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39

Qin, Yongjun. "Gene expression in identified rat hippocampal neurons modulation by corticosteroids and stress /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/73991.

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40

Erkut, Zeynel Abidin. "The stress-axis in multiple sclerosis effects of sepsis, morphine and corticosteroids /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/76821.

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41

Nunes, de Melo Magda. "Inhaled corticosteroids and the risk of exacerbations in chronic obstructive pulmonary disease." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79058.

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In this thesis, composed of two separate articles, we studied the frequency of COPD exacerbations and assessed the effectiveness of inhaled corticosteroids in preventing a first exacerbation of COPD. We used an inception cohort of COPD patients, formed from the computerised databases of Saskatchewan.<br>The rate of COPD exacerbations was 11.5 per 100 person-years. It increased with age and was 50% higher in men than women. Use of inhaled corticosteroids in the year prior to the index date and current use were associated with a small increase in the risk of a first exacerbation (adjusted

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42

Wang, Jiahua. "The role of airway epithelium in airway inflammation and effect of corticosteroids." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300175.

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43

Vathenen, Arumugam Santhire. "The effect of beta agonists and corticosteroids on bronchial reactivity in asthma." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278555.

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44

Bake, Miriam Angela Cannon. "Variability of the Aerodynamic Measures of Leporine Larynges Exposed to Inhaled Corticosteroids." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/9124.

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This thesis examined the effects of combination inhaled corticosteroids (ICs) on the stability of six aerodynamic measures of phonation utilizing a traditional benchtop model with leporine larynges. The motivation for this study was based on the increase of voice disorders associated with IC use in recent years. The aerodynamic measures examined were phonation threshold pressure (PTP), phonation threshold flow (PTF), onset resistance, sustained pressure, sustained flow, and sustained resistance. Leporine larynges were selected as the model for this study due to histological similarities betwee

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45

Maruoka, Ryutaro. "Splenectomy Prolongs the Effects of Corticosteroids in Mouse Models of Autoimmune Hepatitis." Kyoto University, 2014. http://hdl.handle.net/2433/188683.

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46

Kanemitsu, Yoshihiro. "Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids." Kyoto University, 2015. http://hdl.handle.net/2433/199161.

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47

Brar, J. S., and N. K. Bogutska. "Anxiety, alexithymia and attitude to the disease in children with severe bronchial asthma." Thesis, “BIMCO Journal” Abstract book, 2018. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/14303.

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The study of psychological characteristics of the children with bronchial asthma (BA) is extremely relevant in determining the severity of the course of the disease. The purpose of the study was to examine associations between BA severity and personal psychological characteristics. Levels of state (SA), trait (TA) and school anxiety (ScA) with self-reported State Trait Anxiety Inventory (Spielberger and Hanin), School Anxiety Inventory (Phillips) were examined, a Bekhterev institute personality questionnaire (LOBI) was used in order to diagnose the types of attitudes to BA, an adapted To

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48

ANDO, YUICHI, AKIHIRO NAWA, MASAKI SAWADA, et al. "EXTRAVASATION OF PEGYLATED-LIPOSOMAL DOXORUBICIN: FAVORABLE OUTCOME AFTER IMMEDIATE SUBCUTANEOUS ADMINISTRATION OF CORTICOSTEROIDS." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16037.

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49

Rodela, Tamara. "The Role of Corticosteroids in Nitrogen Excretion of the Gulf Toadfish (Opsanus beta)." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19929.

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In contrast to most teleost fish that are ammoniotelic, the gulf toadfish (Opsanus beta) is both facultatively ureogenic and ureotelic. In vivo pharmacological manipulations were used to show that lowering circulating cortisol levels or blocking glucocorticoid receptors (GR) enhanced both urea excretion and urea pulse size. These findings demonstrated that changes in pulsatile urea excretion in the toadfish are mediated by the permissive action of cortisol through GRs. Measurement of urea transport across isolated basolateral gill membranes revealed a cortisol-sensitive carrier mechanism. Cort

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50

Bengtsson, Py, and Klara Carlsson. "Treatment Results after Intra-articular Injection of Corticosteroids in Patients with TMJ Arthritis." Thesis, Umeå universitet, Tandläkarutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97854.

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Arthritis is a common disease affecting the temporomandibular joint. The inflammation causes local pain and decreased function of the masticatory system. Temporomandibular joint arthritis can result from mechanical overloading, general autoimmune disease or individual susceptibility. The aim of this study was to investigate objective and subjective treatment results after intra-articular injection of corticosteroids in patients with temporomandibular joint arthritis. The hypothesis was that treatment with intra-articular injection of corticosteroids relieves clinical signs and subjective sympt

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