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Journal articles on the topic 'Immunotoxicity'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Nakamura, Kazuichi. "Immunotoxicity study." Folia Pharmacologica Japonica 131, no. 3 (2008): 215–19. http://dx.doi.org/10.1254/fpj.131.215.

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2

Collinge, Mark. "Developmental immunotoxicity." Drug Metabolism and Pharmacokinetics 34, no. 1 (2019): S4. http://dx.doi.org/10.1016/j.dmpk.2018.09.019.

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3

Cunningham, Morven, Marco Iafolla, Yada Kanjanapan, et al. "Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy." PLOS ONE 16, no. 6 (2021): e0253070. http://dx.doi.org/10.1371/journal.pone.0253070.

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Background and aims Immune checkpoint inhibitors (ICI) are increasingly used in cancer therapy. Elevated liver enzymes frequently occur in patients treated with ICI but evaluation is poorly described. We sought to better understand causes of liver enzyme elevation, investigation and management. Methods Patients treated with anti-PD-1, PDL-1 or CTLA-4 therapy in Phase I/II clinical trials between August 2012 and December 2018 were included. Clinical records of patients with significant liver enzyme elevations were retrospectively reviewed. Results Of 470 ICI-treated patients, liver enzyme eleva

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4

Wang, Xinge, Na Li, Mei Ma, Yingnan Han, and Kaifeng Rao. "Immunotoxicity in Vitro Assays for Environmental Pollutants under Paradigm Shift in Toxicity Tests." International Journal of Environmental Research and Public Health 20, no. 1 (2022): 273. http://dx.doi.org/10.3390/ijerph20010273.

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With the outbreak of COVID-19, increasingly more attention has been paid to the effects of environmental factors on the immune system of organisms, because environmental pollutants may act in synergy with viruses by affecting the immunity of organisms. The immune system is a developing defense system formed by all metazoans in the course of struggling with various internal and external factors, whose damage may lead to increased susceptibility to pathogens and diseases. Due to a greater vulnerability of the immune system, immunotoxicity has the potential to be the early event of other toxic ef

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5

Sharma, R. P. "Evaluation of Pesticide Immunotoxicity." Toxicology and Industrial Health 4, no. 3 (1988): 373–80. http://dx.doi.org/10.1177/074823378800400309.

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Immunotoxicologic effects have been reported for a number of pesticides. Since pesticides represent a large range of chemical classes, different types of chemicals may affect the complex immune system by a variety of mechanisms. A preliminary evaluation of pesticides for immunotoxicologic potential can best be incorporated in general subacute and chronic toxicity testing, with additional groups assigned for initial host-sensitivity assays. For chemicals that are possible candidates for immunotoxicity in preliminary assays, a comprehensive immunotoxicity screening has been suggested. Finally, e

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6

Chiappelli, Francesco, Michelle A. Kung, Pablo Villanueva, Patricia Lee, Patrick Frost, and Nerissa Prieto. "Immunotoxicity of Cocaethylene." Immunopharmacology and Immunotoxicology 17, no. 2 (1995): 399–417. http://dx.doi.org/10.3109/08923979509019759.

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7

SAKAGUCHI, Takehiro, Sanae SAKAGUCHI, and Yoshiro KUDO. "Immunotoxicity of Beryllium." Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 52, no. 4 (1998): 611–17. http://dx.doi.org/10.1265/jjh.52.611.

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8

Putman, E., J. W. Laan, and H. Loveren. "Assessing immunotoxicity: guidelines." Fundamental and Clinical Pharmacology 17, no. 5 (2003): 615–26. http://dx.doi.org/10.1046/j.1472-8206.2003.00181.x.

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9

Laan, Jan Willem, and Henk Loveren. "Assessing immunotoxicity: guidelines." Fundamental and Clinical Pharmacology 19, no. 3 (2005): 329–30. http://dx.doi.org/10.1111/j.1472-8206.2005.00339.x.

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10

Pfau, Jean C. "Immunotoxicity of asbestos." Current Opinion in Toxicology 10 (August 2018): 1–7. http://dx.doi.org/10.1016/j.cotox.2017.11.005.

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11

Sharma, Raghubir P. "Immunotoxicity of Mycotoxins." Journal of Dairy Science 76, no. 3 (1993): 892–97. http://dx.doi.org/10.3168/jds.s0022-0302(93)77415-9.

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12

Bernier, J., M. Rola-Pleszczynski, K. Krzystyniak, and M. Fournier. "Immunotoxicity of aminocarb." International Journal of Immunopharmacology 10 (January 1988): 144. http://dx.doi.org/10.1016/0192-0561(88)90521-8.

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13

Fournier, M., K. Krzystyniak, D. Nadeau, B. Trottier, and G. Chevalier. "Immunotoxicity of dieldrin." International Journal of Immunopharmacology 10 (January 1988): 144. http://dx.doi.org/10.1016/0192-0561(88)90522-x.

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14

Takahiko Yoshida, Tadakatsu Shimamura, and Sadayoshi Shigeta. "Immunotoxicity of arsenic." International Journal of Immunopharmacology 13, no. 6 (1991): 772. http://dx.doi.org/10.1016/0192-0561(91)90312-u.

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15

Dansette, P. M., E. Bonierbale, C. Minoletti, P. H. Beaune, D. Pessayre, and D. Mansuy. "Drug-induced immunotoxicity." European Journal of Drug Metabolism and Pharmacokinetics 23, no. 4 (1998): 443–51. http://dx.doi.org/10.1007/bf03189993.

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16

Kenna, J. G. "Towards predicting immunotoxicity." Trends in Pharmacological Sciences 11, no. 2 (1990): 88. http://dx.doi.org/10.1016/0165-6147(90)90325-3.

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17

Bernier, Jacques, Michel Fournier, Yves Blais, Pierre Lombardi, Gaston Chevalier, and Krzysztof Krzystyniak. "Immunotoxicity of aminocarb." Pesticide Biochemistry and Physiology 30, no. 3 (1988): 238–50. http://dx.doi.org/10.1016/0048-3575(88)90038-7.

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18

Bernier, Jacques, Marek Rola-Pleszczynski, Denis Flipo, Krzysztof Krzystyniak, and Michel Fournier. "Immunotoxicity of aminocarb." Pesticide Biochemistry and Physiology 36, no. 1 (1990): 35–45. http://dx.doi.org/10.1016/0048-3575(90)90018-w.

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19

Zhu, Yanzhu, Yanfei Li, Liguang Miao, et al. "Immunotoxicity of aluminum." Chemosphere 104 (June 2014): 1–6. http://dx.doi.org/10.1016/j.chemosphere.2013.10.052.

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20

., Raju S., Kavimani S. ., Uma Maheshwara rao V. ., and Sriramulu Reddy K. . "Immunotoxicants, Immunotoxicity and Immunotoxicity testing: An outline of in-vitro alternatives." Journal of Current Pharma Research 1, no. 4 (2011): 341–50. http://dx.doi.org/10.33786/jcpr.2011.v01i04.008.

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21

Vial, T., B. Nicolas, and J. Descotes. "CLINICAL IMMUNOTOXICITY OF PESTICIDES." Journal of Toxicology and Environmental Health 48, no. 3 (1996): 215–29. http://dx.doi.org/10.1080/009841096161294.

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22

Toyoshima, Satoshi. "Immunotoxicity of environmental materials." Japan journal of water pollution research 10, no. 9 (1987): 528–31. http://dx.doi.org/10.2965/jswe1978.10.528.

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23

Dobrovolskaia, Marina A., Dori R. Germolec, and James L. Weaver. "Evaluation of nanoparticle immunotoxicity." Nature Nanotechnology 4, no. 7 (2009): 411–14. http://dx.doi.org/10.1038/nnano.2009.175.

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24

Wehner, Nancy G., Carolyn Gasper, George Shopp, et al. "Immunotoxicity profile of natalizumab." Journal of Immunotoxicology 6, no. 2 (2009): 115–29. http://dx.doi.org/10.1080/15476910902977381.

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25

Harris, David T., Debbie Sakiestewa, Dominic Titone, Raymond F. Robledo, R. Scott Young, and Mark Witten. "Jet fuel-induced immunotoxicity." Toxicology and Industrial Health 16, no. 7-8 (2000): 261–65. http://dx.doi.org/10.1177/074823370001600702.

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26

RODGERS, KATHLEEN, PAAL KLYKKEN, JOSHUA JACOBS, CARMELITA FRONDOZA, VESNA TOMAZIC, and JUDITH ZELIKOFF. "Immunotoxicity of Medical Devices." Toxicological Sciences 36, no. 1 (1997): 1–3. http://dx.doi.org/10.1093/toxsci/36.1.1.

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27

Van Loveren, H., J. Garssen, W. Slob, R. J. Vandebriel, W. H. deJong, and J. G. Vos. "Risk assessment and immunotoxicity." Toxicology Letters 95 (July 1998): 12–13. http://dx.doi.org/10.1016/s0378-4274(98)80048-9.

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28

Hernández, M., R. Inocencio, C. Padilla, M. Macia, and F. F. del Campo. "Immunotoxicity of peptidic cyanotoxins." Toxicology Letters 95 (July 1998): 177. http://dx.doi.org/10.1016/s0378-4274(98)80705-4.

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29

Lee, Dong. "On-target related immunotoxicity." Drug Metabolism and Pharmacokinetics 34, no. 1 (2019): S4. http://dx.doi.org/10.1016/j.dmpk.2018.09.020.

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30

Wheeler, Jennifer. "Nonclinical immunotoxicity testing assessment." Drug Metabolism and Pharmacokinetics 34, no. 1 (2019): S4—S5. http://dx.doi.org/10.1016/j.dmpk.2018.09.022.

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31

Johnson, Arthur G., and Jean Regal. "Immunotoxicity of immunotherapeutic agents." Springer Seminars in Immunopathology 8, no. 4 (1985): 347–59. http://dx.doi.org/10.1007/bf01857389.

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32

Esa, Ahmed H., Glenn A. Warr, and David S. Newcombe. "Immunotoxicity of organophosphorus compounds." Clinical Immunology and Immunopathology 49, no. 1 (1988): 41–52. http://dx.doi.org/10.1016/0090-1229(88)90093-1.

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33

Elsabahy, Mahmoud, and Karen L. Wooley. "Reassessment of nanomaterials immunotoxicity." Nano Today 20 (June 2018): 10–12. http://dx.doi.org/10.1016/j.nantod.2018.01.002.

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34

Descotes, Jacques. "Immunotoxicity of monoclonal antibodies." mAbs 1, no. 2 (2009): 104–11. http://dx.doi.org/10.4161/mabs.1.2.7909.

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35

van Loveren, Henk, Johan Garssen, Cees de Heer, and Joseph G. Vos. "Risk Assessment and Immunotoxicity." Drug Information Journal 31, no. 4 (1997): 1363–67. http://dx.doi.org/10.1177/009286159703100439.

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36

Descotes, Jacques. "Methods of evaluating immunotoxicity." Expert Opinion on Drug Metabolism & Toxicology 2, no. 2 (2006): 249–59. http://dx.doi.org/10.1517/17425255.2.2.249.

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37

Lísková, A. "Immunotoxicity Study of Atrazine." Toxicology Letters 78 (August 1995): 53. http://dx.doi.org/10.1016/03784-2749(59)48296-.

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38

RODGERS, K., P. KLYKKEN, J. JACOBS, C. FRONDOZA, V. TOMAZIC, and J. ZELIKOFF. "Immunotoxicity of Medical Devices☆☆☆." Fundamental and Applied Toxicology 36, no. 1 (1997): 1–14. http://dx.doi.org/10.1006/faat.1996.2279.

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39

Descotes, J., B. Nicolas, and T. Vial. "Assessment of immunotoxic effects in humans." Clinical Chemistry 41, no. 12 (1995): 1870–73. http://dx.doi.org/10.1093/clinchem/41.12.1870.

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Abstract The immunotoxic effects of chemicals are varied and markedly different depending on the underlying pathogenesis, namely, direct immunotoxicity (including immunosuppression, immunodepression, and immunostimulation), hypersensitivity, and autoimmunity. A large number of immunological endpoints and functional assays have been proposed for use as biomarkers of immunotoxicity, but they often lack sensitivity or are poorly standardized, so that their relevance in assessing immunotoxic effects in humans is at best ill established. Examining sentinel immunopathological events in individuals w

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40

Langezaal, Ingrid, Sebastian Hoffmann, Thomas Hartung, and Sandra Coecke. "Evaluation and Prevalidation of an Immunotoxicity Test Based on Human Whole-blood Cytokine Release." Alternatives to Laboratory Animals 30, no. 6 (2002): 581–95. http://dx.doi.org/10.1177/026119290203000605.

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Immunotoxicology is a relatively new field in toxicology, and is one of emerging importance, because immunotoxicity appears to contribute to the development of cancer, autoimmune disorders, allergies and other diseases. At present, there is a lack of human cell-based immunotoxicity assays for predicting the toxicity of xenobiotics toward the immune system in a simple, fast, economical and reliable way. Existing immunotoxicity tests are mainly performed in animals, although species differences favour human-based testing. Whole-blood cytokine release models have attracted increasing interest, an

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41

Lian, Huan, Yu Liu, Linnan Ke, and Qianqian Han. "Deciphering Immunotoxicity in Animal-Derived Biomaterials: A Genomic and Bioinformatics Approach." International Journal of Molecular Sciences 25, no. 20 (2024): 10963. http://dx.doi.org/10.3390/ijms252010963.

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Immunotoxicity evaluation has been crucial in preclinical testing for implantable animal-derived biomaterials due to their prolonged contact with the human body, which requires stringent safety assessments. By creating experimental models with varying levels of immunotoxicity, this study reveals the decisive role of decellularization treatment in diminishing the immunogenicity of materials, thus ensuring clinical safety. Employing cutting-edge differential gene expression analysis, the research not only accurately quantifies gene expression alterations in immune responses but also, through pat

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42

Holladay, S. D., and B. L. Blaylock. "The mouse as a model for developmental immunotoxicology." Human & Experimental Toxicology 21, no. 9-10 (2002): 525–31. http://dx.doi.org/10.1191/0960327102ht292oa.

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The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure. Assays utilized have historically been those developed for adult mice. Clear gaps in the available database exist, however, regarding the predictive strength of adult mouse immune screens for detecting either transient or long-lasting postnatal immune suppression. Limited information is also available regarding postnatal ages when various immune assays can be first employed to detect developmental immunotoxicity in mice. Furthermore, diff

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43

Lin, Wang, Tien-Chieh Hung, Tomofumi Kurobe, Yi Wang, and Pinhong Yang. "Microcystin-Induced Immunotoxicity in Fishes: A Scoping Review." Toxins 13, no. 11 (2021): 765. http://dx.doi.org/10.3390/toxins13110765.

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Cyanobacteria (blue-green algae) have been present on Earth for over 2 billion years, and can produce a variety of bioactive molecules, such as cyanotoxins. Microcystins (MCs), the most frequently detected cyanotoxins, pose a threat to the aquatic environment and to human health. The classic toxic mechanism of MCs is the inhibition of the protein phosphatases 1 and 2A (PP1 and PP2A). Immunity is known as one of the most important physiological functions in the neuroendocrine-immune network to prevent infections and maintain internal homoeostasis in fish. The present review aimed to summarize e

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44

Schamber, R. A., E. L. Belden, and M. F. Raisbeck. "Immunotoxicity of Chronic Selenium Exposure." Journal American Society of Mining and Reclamation 195, no. 1 (1995): 384–394393. http://dx.doi.org/10.21000/jasmr95010384.

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45

Stefanidou, Maria, Ariadni C. Loutsidou, Christos T. Chasapis, and Chara A. Spiliopoulou. "Immunotoxicity of Cocaine and Crack." Current Drug Abuse Reviewse 4, no. 2 (2011): 95–97. http://dx.doi.org/10.2174/1874473711104020095.

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46

Corsini, E. "Evaluating cytokines in immunotoxicity testing." Toxicology Letters 350 (September 2021): S8. http://dx.doi.org/10.1016/s0378-4274(21)00251-4.

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47

Wesley, Sarah F., Aya Haggiagi, Kiran T. Thakur, and Philip L. De Jager. "Neurological Immunotoxicity from Cancer Treatment." International Journal of Molecular Sciences 22, no. 13 (2021): 6716. http://dx.doi.org/10.3390/ijms22136716.

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The emergence of immune-based treatments for cancer has led to a growing field dedicated to understanding and managing iatrogenic immunotoxicities that arise from these agents. Immune-related adverse events (irAEs) can develop as isolated events or as toxicities affecting multiple body systems. In particular, this review details the neurological irAEs from immune checkpoint inhibitors (ICI) and chimeric antigen receptor (CAR) T cell immunotherapies. The recognition and treatment of neurological irAEs has variable success, depending on the severity and nature of the neurological involvement. Un

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48

Descotes, Jacques, Brigitte Nicolas, Thierry Vial, and Jean-François Nicolas. "Biomarkers of immunotoxicity in man." Biomarkers 1, no. 2 (1996): 77–80. http://dx.doi.org/10.3109/13547509609088673.

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49

Assumaidaee, Ajwad A. M. "Zearalenone Mycotoxicosis: Pathophysiology and Immunotoxicity." Iraqi Journal of Veterinary Medicine 44, no. 1 (2020): 29–38. http://dx.doi.org/10.30539/ijvm.v44i1.932.

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Mycotoxicosis refers to the deleterious pathological effects of different types toxins produced by some worldwide distributing fungi. Mycotoxins, as secondary metabolites are affecting different organs and systems both in animal and human beings. Zeralenone (ZEA), the well-known estrogenic mycotoxins, is an immunotoxic agent. This macrocyclic beta-resorcyclic acid lactone, is mycotoxin procreated as a secondary metabolic byproduct by several types of Fusarium, encompassing F. roseum,F. culmorum, F. graminearum and different other types. Attributing to its potent estrogenic activity, ZEA has be

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50

Karol, Meryl H., and Ruzhi Jin. "Mechanisms of immunotoxicity to isocyanates." Chemical Research in Toxicology 4, no. 5 (1991): 503–9. http://dx.doi.org/10.1021/tx00023a001.

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