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Journal articles on the topic 'Imp3p'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Lee, Sarah J., and Susan J. Baserga. "Imp3p and Imp4p, Two Specific Components of the U3 Small Nucleolar Ribonucleoprotein That Are Essential for Pre-18S rRNA Processing." Molecular and Cellular Biology 19, no. 8 (August 1, 1999): 5441–52. http://dx.doi.org/10.1128/mcb.19.8.5441.

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ABSTRACT The function of the U3 small nucleolar ribonucleoprotein (snoRNP) is central to the events surrounding pre-rRNA processing, as evidenced by the severe defects in cleavage of pre-18S rRNA precursors observed upon depletion of the U3 RNA and its unique protein components. Although the precise function of each component remains unclear, since U3 snoRNA levels remain unchanged upon genetic depletion of these proteins, it is likely that the proteins themselves have significant roles in the cleavage reactions. Here we report the identification of two previously undescribed protein components of the U3 snoRNP, representing the first snoRNP components identified by using the two-hybrid methodology. By screening for proteins that physically associate with the U3 snoRNP-specific protein, Mpp10p, we have identified Imp3p (22 kDa) and Imp4p (34 kDa) (named for interacting with Mpp10p). The genes encoding both proteins are essential in yeast. Genetic depletion reveals that both proteins are critical for U3 snoRNP function in pre-18S rRNA processing at the A0, A1, and A2 sites in the pre-rRNA. Both Imp proteins associate with Mpp10p in vivo, and both are complexed only with the U3 snoRNA. Conservation of RNA binding domains between Imp3p and the S4 family of ribosomal proteins suggests that it might associate with RNA directly. However, as with other U3 snoRNP-specific proteins, neither Imp3p nor Imp4p is required for maintenance of U3 snoRNA integrity. Imp3p and Imp4p are therefore novel protein components specific to the U3 snoRNP with critical roles in pre-rRNA cleavage events.

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2

Wehner, Karen A., Jennifer E. G. Gallagher, and Susan J. Baserga. "Components of an Interdependent Unit within the SSU Processome Regulate and Mediate Its Activity." Molecular and Cellular Biology 22, no. 20 (October 15, 2002): 7258–67. http://dx.doi.org/10.1128/mcb.22.20.7258-7267.2002.

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ABSTRACT The SSU processome is required for production of the small ribosomal subunit RNA, the 18S rRNA. Specifically, the U3 small nucleolar RNA (snoRNA) component of the SSU processome is essential for the formation of the conserved central pseudoknot and for cleavages of the pre-rRNA, both of which are required for 18S maturation. To further elucidate how these events are mediated, we examined the regulatory and mechanistic roles of the U3 specific proteins: Imp3p, Imp4p, and Mpp10p. We found that these proteins demonstrated an interdependence with respect to their stability and to their association with the U3 snoRNA. Because mutations in the U3 snoRNA that disrupt pre-rRNA processing confer similar defects on growth and pre-rRNA processing as do carboxy-terminal truncations of Mpp10p, we hypothesized that Mpp10p may be involved in maintaining U3 snoRNA-pre-rRNA base pairing. However, combining the two mutations resulted in a more pronounced cleavage defect at site A2, suggesting that Mpp10p is also required at an additional mechanistic step. Furthermore, heterologous complementation experiments demonstrate that the last 95 amino acids of yeast Mpp10p are specifically required for growth and pre-rRNA processing at low temperatures.

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Gerczei, T., and C. C. Correll. "Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA." Proceedings of the National Academy of Sciences 101, no. 43 (October 15, 2004): 15301–6. http://dx.doi.org/10.1073/pnas.0406819101.

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4

Hsieh, Yi-Ching, Pei-Jung Tu, Ying-Yuan Lee, Chun-Chen Kuo, Yi-Chien Lin, Chi-Fang Wu, and Jing-Jer Lin. "The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein." Biochemical Journal 408, no. 3 (November 28, 2007): 387–93. http://dx.doi.org/10.1042/bj20070968.

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Imp4p is a component of U3 snoRNP (small nucleolar ribonucleoprotein) involved in the maturation of 18S rRNA. We have shown that Imp4p interacts with Cdc13p, a single-stranded telomere-binding protein involved in telomere maintenance. To understand the role of Imp4p in telomeres, we purified recombinant Imp4p protein and tested its binding activity towards telomeric DNA using electrophoretic mobility-shift assays. Our results showed that Imp4p bound specifically to single-stranded telomeric DNA in vitro. The interaction of Imp4p to telomeres in vivo was also demonstrated by chromatin immunoprecipitation experiments. Significantly, the binding of Imp4p to telomeres was not limited to yeast proteins, since the hImp4 (human Imp4) also bound to vertebrate single-stranded telomeric DNA. Thus we conclude that Imp4p is a novel telomeric DNA-binding protein that, in addition to its role in rRNA processing, might participate in telomere function.

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Feng, Wei, Zhongren Zhou, Jeffrey H. Peters, Thaer Khoury, Qihui Zhai, Qiying Wei, Camtu D. Truong, Sonya Wei Song, and Dongfeng Tan. "Expression of Insulin-Like Growth Factor II mRNA-Binding Protein 3 in Human Esophageal Adenocarcinoma and Its Precursor Lesions." Archives of Pathology & Laboratory Medicine 135, no. 8 (August 1, 2011): 1024–31. http://dx.doi.org/10.5858/2009-0617-oar2.

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Context.—Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but only rarely within adult benign tissues. The expression of IMP3 in esophageal adenocarcinoma (EAC) and its precursor lesions including distinctive type Barrett mucosa (BM, intestinal metaplasia) and esophageal columnar dysplasia (ECD) is largely unknown. Objective.—To characterize the patterns of IMP3 expression in EAC and its precursor lesions. Design.—Samples from 132 cases of EAC, 28 cases of ECD (16 high-grade dysplasia and 12 low-grade dysplasia cases), 28 cases of BM without dysplasia, and 138 cases of nonneoplastic esophageal mucosa without dysplasia or BM within formalin-fixed, paraffin-embedded tissue microarray blocks were examined. Tissues were stained with mouse monoclonal anti-IMP3 antibody. The intensity (1–3+) and percent (0%–100%) of positive cytoplasmic and/or membranous IMP3 staining cells were determined. Results.—Most of EAC cases (93 of 132; 70%) showed cytoplasmic and membranous IMP3 staining. Poorly and moderately differentiated EAC showed statistically significant higher IMP3 expression compared with well-differentiated EAC (P < .001). A subset of ECD cases (7 of 28; 25%) was positive for IMP3, including 3 low-grade dysplasia cases (focal 1+ IMP3 staining) and 4 high-grade dysplasia cases (more diffuse 1–2+ IMP3 staining). No IMP3 staining was observed in any nonneoplastic esophageal mucosa and BM tissues without dysplasia. Conclusions.—This study suggests that IMP3 may play a role in the carcinogenesis of EAC and has diagnostic utility in differentiating neoplastic and nonneoplastic lesions of the esophagus.

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6

Hao, Suyang, Thomas W. Smith, Peigou G. Chu, Qin Liu, Chi Young Ok, Bruce A. Woda, Di Lu, et al. "The Oncofetal Protein IMP3: A Novel Molecular Marker to Predict Aggressive Meningioma." Archives of Pathology & Laboratory Medicine 135, no. 8 (August 1, 2011): 1032–36. http://dx.doi.org/10.5858/2009-0652-oar2.

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Context.—One of the major clinical challenges is to predict recurrence of meningioma. Recently, we have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors. Objective.—To investigate whether IMP3 can be used as a new biomarker to predict the recurrence and overall survival of patients with meningiomas. Design.—One hundred seven patients with primary meningiomas were investigated for expression of IMP3 by immunohistochemistry and whether expression of this molecule correlated with tumor recurrence and overall survival. Results.—Tumor recurrence was found in 13 of 107 patients with primary meningioma. Seven of 107 patients (6.5%) with primary meningiomas expressed IMP3. Kaplan-Meier plots and log-rank tests showed that patients with IMP3-positive tumors had a much higher recurrence rate (P = .004) and a poorer overall survival (P < .001) than did patients with IMP3-negative tumors. The 5-year recurrence-free and overall survival rates were 0% and 36% in IMP3-positive patients versus 89% and 94% in IMP3-negative patients, respectively. Multivariable analysis of IMP3 status (positive versus negative) in primary tumors showed a hazard ratio of 17.89 for recurrence (P = .01), which was much higher than hazard ratios associated with all other known risk factors including higher tumor grades and Ki-67 labeling index. Conclusions.—IMP3 is a potential independent prognostic biomarker that can be used at the time of initial diagnosis of meningioma to identify patients who have a high risk of developing a recurrence.

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Plum, Patrick, Dita Ulase, Seung-Hun Chon, Felix Berlth, Thomas Zander, Hakan Alakus, Elfriede Bollschweiler, et al. "PS02.197: UPREGULATION OF IMP3 HAS A NEGATIVE PROGNOSTIC IMPACT IN EARLY INVASIVE ESOPHAGEAL ADENOCARCINOMA." Diseases of the Esophagus 31, Supplement_1 (September 1, 2018): 178. http://dx.doi.org/10.1093/dote/doy089.ps02.197.

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Abstract Background Despite improvements in perioperative treatments, the overall survival of patients with esophageal adenocarcinoma (EAC) remains low. In early invasive tumors (pT1) there is striking risk discrepancy for tumors with vascular invasion (L1/V1). As this tumor stage is potentially locally resectable, there is an urgent need for reliable pretherapeutical evaluation. High expression of IMP3 correlates with worse prognosis in colon and gastric cancer. In a small series of 30 patients with EAC, IMP3 is significantly associated with lymphovascular invasion. In our large cohort of EAC, we analyzed the immunohistochemical expression of IMP3 in correlation to clinical data. Methods 371 patients who underwent esophagectomy due to EAC at the Department of General, Visceral and Cancer Surgery, University of Cologne between 1999 and 2012 were included. Tissue Microarrays (TMA) were retrospectively established from the formalin-fixed, paraffin embedded material of the resected specimens and immunohistochemically stained using the primary antibody specific for IMP3. The IMP3 staining intensity was scored manually according to a 3-tier-scoring system (negative, weak and strong). Results TMAs from 371 patients were interpretable for further analysis. 109 patients (29.3%) had superficial EAC (pT1a/pT1b) while 262 (70.7%) showed locally advanced tumors (pT2 or pT3). 67 (26.7%) patients with advanced tumors and all pT1 EAC patients did not receive neoadjuvant therapy (chemotherapy or chemo-radiotherapy) prior to surgery. 259 of the 371 EAC revealed positive immunostaining for IMP3 including 167 strongly and 92 weakly positive. For patients without neoadjuvant therapy, there was a significant trend for higher IMP3 expression in early invasive tumors (pT1a/pT1b) showing significantly higher rates of IMP3 positive tumors compared to locally advanced pT3-tumors without neoadjuvant therapy (P = 0.0015). There was no difference of IMP3 expression according to neoadjuvant therapy in patients with pretreated EAC. There is a statistically significant association between IMP3 protein expression and shortened survival in early invasive pT1-esophageal carcinomas (P = 0.045). Conclusion IMP3 is a feasible marker in early invasive EAC (pT1a and pT1b) and is significantly associated with worse outcome. IMP3 indicates lymph node metastases, advanced infiltration depth and higher tumor grade. Thus IMP3 might be useful for therapeutic decisions in early invasive EAC. Disclosure All authors have declared no conflicts of interest.

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Wei, Ping, Dawei Li, Ye Xu, Sanjun Cai, and Xiang Du. "Effect of IMP3 on epithelial-to-mesenchymal transition and the function of colon cancer stem cells." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): 631. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.631.

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631 Background: EMT could promote the acquisition of stem-like properties in cancer cells and cancer stem cell (CSC) has EMT properties. However, the underlying mechanism of the interaction between EMT and CSC still remain unclear. We previously identified Insulin-like growth factor-II mRNA-binding protein 3 (IMP3) plays a vital role in colon cancer carcinogenesis. Here, we aimed to identify the gene function between EMT and CSC in colon cancer. Methods: The expression of IMP3 was analyzed in human tumor tissues. Colonospheres were isolated from colon cancer cell lines and the biological features of IMP3 were investigated in the process of EMT and colonoshpere cells. Results: Increased IMP3 levels were significantly correlated with higher clinical stage, T classification, LNM, presence of distant metastasis. Patients with IMP3-positive localized tumors had lower 5-year disease-free survival (DFS) and overall survival (OS) than those with IMP3-negative tumors. Multivariate survival analysis showed that IMP3 was an independent prognostic marker for DFS and OS. Expanded colonospheres contained cells that expressed high levels of CD133 and had the ability to promote migration and activate the epithelial-mesenchymal transition. Down regulation of IMP3 in HCT116 cells inhibited the invasion, migration ability and epithelial-mesenchymal transition and the properties of colonospheres. Conclusions: These findings suggest that IMP3 plays an important role in colon cancer tumorigenesis and metastasis through transactivation of colon CSC with EMT property, which is helpful to identify critical marker and therapeutic target.

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Del Gobbo, Alessandro, Emanuela Bonoldi, Fulvia Milena Cribiù, Ilaria Franceschetti, Caterina Matinato, Stefano Fiori, Umberto Gianelli, and Silvano Bosari. "Insulin-like growth factor II mRNA binding protein 3 (IMP3) expression in cervical intraepithelial neoplasia and its relationship with HIV-infection status." Sexual Health 12, no. 1 (2015): 22. http://dx.doi.org/10.1071/sh13144.

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Background Cervical cancer is preventable through screening, and HIV treatment guidelines recommend that all HIV-infected women receive cervical cancer twice during the year after HIV diagnosis and annually thereafter. Different immunohistochemical markers have been studied to highlight cervical intraepithelial lesions of low and high grade, the most widely used being p16. Recent studies have shown that insulin-like growth factor mRNA binding protein 3 (IMP3) plays a role in the development of invasive squamous cell carcinoma from cervical dysplasia, both in histology and in liquid-based cytology. Methods: We evaluated the clinical significance of the immunohistochemical expression of IMP3 and p16 in histological samples of cervical intraepithelial neoplasia from 56 samples of HIV-positive and 30 samples of HIV-negative patients. Results: A significant difference was found in IMP3 and p16 protein expression between HIV-positive and HIV-negative specimens. All cases of HIV-positive low grade squamous intraepithelial neoplasia (L-SIL) with IMP3 expression progressed in high grade (H)-SIL. However, the HIV-positive patients with IMP3-negative L-SIL remained stable or had a negative follow up. The L-SIL of HIV-negative patients with IMP3 protein expression had an uneventful follow up. IMP3-positive H-SIL recurred with low- or high-grade dysplasia during follow up after conisation in both populations. All IMP3-negative L-SIL and H-SIL had negative pap tests at follow up. Conclusions: In HIV-positive cases, IMP3 showed a higher sensitivity than p16 in identifying patients at risk of progression and recurrence.

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Bucelli, Robert C., and Alan Pestronk. "Immune myopathies with perimysial pathology." Neurology - Neuroimmunology Neuroinflammation 5, no. 2 (January 18, 2018): e434. http://dx.doi.org/10.1212/nxi.0000000000000434.

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ObjectiveImmune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium. We studied the clinical and laboratory correlates of patients with pathologically defined IMPP.MethodsThis is a retrospective chart and pathology review of 57 consecutive patients with IMPP myopathology and, for comparison, 20 patients with dermatomyositis with vascular pathology (DM-VP).ResultsCompared with DM-VP, IMPP patients more commonly had interstitial lung disease (ILD) (p < 0.01), Raynaud phenomenon (p < 0.05), mechanic's hands (p < 0.05), arthralgias (p < 0.001), and a sustained response to immunomodulatory therapy (p < 0.05), and less frequently had a concurrent malignancy (p < 0.01). IMPP patients had higher serum creatine kinase values (p < 0.05), more frequent serum Jo-1 (p < 0.03) or SSA/SSA52 autoantibodies (p < 0.05), and less frequent antinuclear antibodies (p < 0.01). IMPP patients with serum Jo-1/antisynthetase antibodies were more likely to have ILD (p < 0.05) and inflammatory arthritis (p < 0.05) than IMPP patients without these antibodies.ConclusionsIMPP myopathology is associated with an increased risk of ILD, Raynaud phenomenon, mechanic's hands, and inflammatory arthritis when compared with another immune myopathy (DM-VP). IMPP patients require regular screening for ILD, particularly those with antisynthetase antibodies. The absence of myositis-specific autoantibodies in a large percentage of IMPP patients emphasizes the important role for myopathology in identifying patients at higher risk of severe comorbid conditions such as ILD.

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Del Gobbo, Alessandro, Valentina Vaira, Lucia Ferrari, Carlo Patriarca, Andrea Di Cristofori, Dario Ricca, Manuela Caroli, Paolo Rampini, Silvano Bosari, and Stefano Ferrero. "The Oncofetal Protein IMP3: A Novel Grading Tool and Predictor of Poor Clinical Outcome in Human Gliomas." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/413897.

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Morphologic criteria illustrated in WHO guidelines are the most significant prognostic factor in human gliomas, but novel biomarkers are needed to identify patients with a poorer outcome. The present study examined the expression of the oncofetal protein IMP3 in a series of 135 patients affected by high-grade (grade III and IV) gliomas, correlating the results with proliferative activity, molecular parameters, and clinical and follow-up data. Overall, IMP3 expression was higher in glioblastomas (68%) than in grade III tumors (20%,P<0.0001), and IMP3-positive high-grade gliomas showed a shorter overall and disease-free survival than negative ones (P=0.0002andP=0.006, resp.). IMP3 expression was significantly associated with the absence of mutations of IDH1 gene (P=0.0001) and with the unmethylated phenotype of MGMT in high-grade gliomas (P=0.004). High Ki67 levels were correlated with better prognosis in glioblastomas but IMP3 expression was not correlated with the proliferation index. These findings confirm the role of IMP3 as a marker of poor outcome, also in consideration of its association with IDH1 wild-type phenotype and MGMT unmethylated status. The data suggest that IMP3 staining could identify a subgroup of patients with poor prognosis and at risk of recurrence in high-grade gliomas.

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Hakim, Sarah A., Nermine M. Abd Raboh, and Lobna S. Shash. "IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma." Analytical Cellular Pathology 2021 (February 16, 2021): 1–10. http://dx.doi.org/10.1155/2021/6639834.

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Sinonasal inverted papilloma (IP) has a propensity for malignant transformation. Although the IP-associated squamous cell carcinoma (SCC) is rare, it has a poor prognosis. To the best of our knowledge, this is the first study to assess IMP3 immunohistochemical (IHC) expression in sinonasal tumors and to compare it to the Ki-67 IHC expression and to other established clinicopathological parameters. A retrospective study was conducted on three groups which consisted of 72 cases of sinonasal IP, 20 age-matched samples of normal respiratory epithelium, and 15 cases of sinonasal SCC associated with IP, which were obtained from the archives of the Pathology Lab of Ain Shams University Specialized and Ain Shams University Hospitals during the period from January 2012 to December 2019. An IHC study was performed to evaluate IMP3 and Ki-67 expression in the three groups, with correlation of IMP3 expression to established clinicopathological parameters of sinonasal SCC on top of IP. Both IMP3 and Ki-67 showed a sharp rise in expression in the sinonasal SCC group. In addition, there were statistically significant differences in expression values between the 3 groups ( P = 0.001 ). Receiver Operating Characteristic (ROC) analysis revealed that IMP3 and Ki-67 could be used to discriminate sinonasal SCC from control and IP lesions, with sensitivity and specificity of 100% and 81.5% for IMP3, respectively, and 100% and 62.5% for Ki-67, respectively. Spearman’s rho revealed that both IMP3 and Ki-67 were significantly related to the lymph node and tumor stages but not to the tumor grade. ROC analysis was performed to select cut-off scores for progression and survival for IMP3, and accordingly, Kaplan-Meier analysis showed correlation between IMP3 and overall survival, local recurrence-free survival, and metastasis-free survival in sinonasal SCC cases at the selected cut-off values. Based on our results, IMP3 could serve as a promising diagnostic, prognostic, and therapeutic marker for IP-associated sinonasal SCC.

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Hammer, Niels A., Thomas v. O. Hansen, Anne Grete Byskov, Eva Rajpert-De Meyts, Marie Louise Grøndahl, Helle E. Bredkjær, Ulla M. Wewer, Jan Christiansen, and Finn C. Nielsen. "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer." Reproduction 130, no. 2 (August 2005): 203–12. http://dx.doi.org/10.1530/rep.1.00664.

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Insulin-like growth factor-II mRNA-binding proteins 1, 2 and 3 (IMP1, IMP2 and IMP3) belong to a family of RNA-binding proteins implicated in mRNA localization, turnover and translational control. We examined their expression pattern during development of murine and human testis and ovaries. In the mouse, IMPs were expressed in male and female gonadal cells at embryonic day 12.5 (E12.5). From E16.5, IMP1 and IMP3 became restricted to the developing germ cells, whereas IMP2 expression persisted in the interstitial cells. In mature mouse and human ovaries, IMP1, IMP2 and IMP3 were detected in resting and growing oocytes and in the granulosa cells. In testis, IMP1 and IMP3 were found mainly in the spermatogonia, whereas IMP2 was expressed in the immature Leydig cells. Moreover, all three IMPs were detected in human semen. The developmental expression pattern of IMP1 and IMP3 in the human testis prompted us to examine their possible involvement in testicular neoplasia. IMPs were detected primarily in germ-cell neoplasms, including preinvasive testicular carcinoma in situ, classical and spermatocytic seminoma, and nonseminomas, with particularly high expression in undifferentiated embryonal carcinoma. The relative expression of IMP1, IMP2 and IMP3 varied among tumor types and only IMP1 was detected in all carcinoma in situ cells. Thus IMPs, and in particular IMP1, may be useful auxiliary markers of testicular neoplasia.

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Zheng, Sanduo, and Keqiong Ye. "Purification, crystallization and preliminary X-ray diffraction analysis of Imp3 in complex with an Mpp10 peptide involved in yeast ribosome biogenesis." Acta Crystallographica Section F Structural Biology Communications 70, no. 7 (June 18, 2014): 918–21. http://dx.doi.org/10.1107/s2053230x14010905.

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Eukaryotic ribosome synthesis requires a vast number of transiently associated factors. Mpp10, Imp3 and Imp4 form a protein complex in the 90S pre-ribosomal particle that conducts early processing of 18S rRNA. Here, a short fragment of Mpp10 was identified to associate with and increase the solubility of Imp3. An Imp3–Mpp10 complex was co-expressed, co-purified and co-crystallized. Preliminary X-ray diffraction analysis revealed that the crystal diffracted to 2.1 Å resolution and belonged to space groupP212121, with unit-cell parametersa= 51.6,b= 86.9,c= 88.7 Å.

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Liu, Junhui, Xindu Chen, Zeqin Lin, and Shipu Diao. "Multiobjective Optimization of Injection Molding Process Parameters for the Precision Manufacturing of Plastic Optical Lens." Mathematical Problems in Engineering 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/2834013.

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Injection molding process parameters (IMPP) have a significant effect on the optical performance and surface waviness of precision plastic optical lens. This paper presents a set of procedures for the optimization of IMPP, with haze ratio (HR) reflecting the optical performance and peak-to-valley 20 (PV20) reflecting the surface waviness as the optimization objectives. First, the orthogonal experiment was carried out with the Taguchi method, and the results were analyzed by ANOVA to screen out the IMPP having a significant effect on the objectives. Then, the 34 full-factor experiment was conducted on the key IMPP, and the experimental results were used as the training and testing samples. The BPNN algorithm and the M-SVR algorithm were applied to establish the mapping relationships between the IMPP and objectives. Finally, the multiple-objective optimization was performed by applying the nondominated sorting genetic algorithm (NSGA-II), with the built M-SVR models as the fitness function of the objectives, to obtain a Pareto-optimal set, which improved the quality of plastic optical lens comprehensively. Through the experimental verification on the optimization results, the mean prediction error (MPE) of HR and PV20 is 7.16% and 9.78%, respectively, indicating that the optimization method has high accuracy.

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Pot, Isabelle, Vivien Measday, Brian Snydsman, Gerard Cagney, Stanley Fields, Trisha N. Davis, Eric G. D. Muller, and Philip Hieter. "Chl4p and Iml3p Are Two New Members of the Budding Yeast Outer Kinetochore." Molecular Biology of the Cell 14, no. 2 (February 2003): 460–76. http://dx.doi.org/10.1091/mbc.e02-08-0517.

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Kinetochore proteins contribute to the fidelity of chromosome transmission by mediating the attachment of a specialized chromosomal region, the centromere, to the mitotic spindle during mitosis. In budding yeast, a subset of kinetochore proteins, referred to as the outer kinetochore, provides a link between centromere DNA-binding proteins of the inner kinetochore and microtubule-binding proteins. Using a combination of chromatin immunoprecipitation, in vivo localization, and protein coimmunoprecipitation, we have established that yeast Chl4p and Iml3p are outer kinetochore proteins that localize to the kinetochore in a Ctf19p-dependent manner. Chl4p interacts with the outer kinetochore proteins Ctf19p and Ctf3p, and Iml3p interacts with Chl4p and Ctf19p. In addition, Chl4p is required for the Ctf19p-Ctf3p and Ctf19p-Iml3p interactions, indicating that Chl4p is an important structural component of the outer kinetochore. These physical interaction dependencies provide insights into the molecular architecture and centromere DNA loading requirements of the outer kinetochore complex.

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Yousaf, Malik Muhammad, Muhammad Majeed, Mumtaz Hussain, Muhammad Jahangir Shah, Bashir Ahmad, Hafiz Muhammad Zia Ullah Ghazali, and Rao Wali Muhammad. "Calcium alginate entrapment of Aspergillus nidulans IMPP-0785 laccase for enhanced enzyme catalytic ability, thermost ability and dye-decolorization." Bangladesh Journal of Botany 47, no. 4 (December 31, 2018): 903–9. http://dx.doi.org/10.3329/bjb.v47i4.47380.

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Production of laccase using a solid-state culture of Aspergillus nidulans IMPP-0785 was optimized using barley bran. Aspergillus nidulans IMPP-0785 laccase optimum activity was observed with filtrate (29.15 U/g) as compared to supernatant and unfiltered. Free laccase and supernatant gave best results at 30.24 and 25.95 U/g, respectively for 20 min incubation time. The entrapped spores of A. nidulans IMPP-0785 showed maximal activity (16.12 U/g) at incubation time for 60 min. Immobilized laccase resulted optimal activity (29.24 U/g) for 25 min of incubation. Enzyme showed higher thermo stability of 34.28 U/g when incubated for 35 min.

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Masson, Jean-Yves, and Dindial Ramotar. "The Transcriptional Activator Imp2p Maintains Ion Homeostasis in Saccharomyces cerevisiae." Genetics 149, no. 2 (June 1, 1998): 893–901. http://dx.doi.org/10.1093/genetics/149.2.893.

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Abstract Yeast cells deficient in the transcriptional activator Imp2p are viable, but display marked hypersensitivity to a variety of oxidative agents. We now report that imp2 null mutants are also extremely sensitive to elevated levels of the monovalent ions, Na+ and Li+, as well as to the divalent ions Ca2+, Mn2+, Zn2+, and Cu2+, but not to Cd2+, Mg2+, Co2+, Ni2+, and Fe2+, as compared to the parent strain. We next searched for multicopy suppressor genes that would allow the imp2Δ mutant to grow under high salt conditions. Two genes that independently restored normal salt-resistance to the imp2Δ mutant, ENA1 and HAL3, were isolated. ENA1 encodes a P-type ion pump involved in monovalent ion efflux from the cell, while HAL3 encodes a protein required for activating the expression of Ena1p. Neither ENA1 nor HAL3 gene expression was positively regulated by Imp2p. Moreover, the imp2 ena1 double mutant was exquisitely sensitive to Na+/Li+ cations, as compared to either single mutant, implying that Imp2p mediates Na+/Li+ cation homeostasis independently of Ena1p.

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Burnett, Atuhani S., Dare Ajibade, Stephen Peters, Sushil Ahlawat, Omar Mahmoud, and Ravi Chokshi. "A sensitive biomarker panel to distinguish pancreaticobiliary malignancies from benign disease." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 238. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.238.

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238 Background: Biliary strictures present a diagnostic challenge to differentiate benign disease from hepatopancreaticobiliary (HPB) malignancies. Cytology from Endoscopic retrograde cholangiopancreatography (ERCP) or Endoscopic ultrasound with fine needle aspiration (EUS-FNA) have both been plagued by poor sensitivity and high false negative rates. In a review of over 80 adjunct molecular biology tests that have been attempted on ERCP and EUS-FNA samples, four immunohistochemistry biomarkers with sensitivities ranging 74-80% were identified; von Hippel Lindau loss of expression (VHL), over-expression of insulin-like growth factor 2 mRNA-binding Protein 3 (IMP3), and EF-hand Calcium 2+ binding S100 subfamily members A4 (S100A4) and P (S100P). We sought to determine if these results could be validated in a tumor explant model and furthermore if combining these tests into a biomarker panel could boost overall diagnostic sensitivity to 100%. Methods: Tumor tissue and normal surrounding pancreas from 27 pancreaticoduodenectomy specimens were selected by an experienced pathologist, subjected to immunohistochemistry staining with VHL, IMP3, S100A4, S100P, and the intensity and percent of cells staining was graded. Using ROC curve analysis, threshold criteria were chosen for each biomarker to differentiate between tumor and normal pancreas. Biomarkers were then evaluated as a panel for their ability to discriminate malignant from benign specimens. Results: Individual sensitivity of VHL, IMP3, S100A4, and S100P were found to be 75.0%, 79.2%, 45.8%, and 0%. When VHL, IMP3, and S100A4 were grouped into a panel, they were able to distinguish cancer from normal tissue with a sensitivity of 100% and a specificity of 96%. S100P was dispensable in our assay and only VHL, IMP3, and S100A4 staining were required to achieve 100% sensitivity. Conclusions: A panel of three biomarkers, VHL, IMP3, and S100A4, were able to distinguish pancreatic cancer from surrounding normal tissue with 100% sensitivity in our tumor explant model. Prospective studies on patient biopsy specimens are required to further validate the clinical use of this biomarker panel.

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Jiang, Zhong, Christine M. Lohse, Peigou G. Chu, Chin-Lee Wu, Bruce A. Woda, Kenneth L. Rock, and Eugene D. Kwon. "Oncofetal protein IMP3." Cancer 112, no. 12 (June 15, 2008): 2676–82. http://dx.doi.org/10.1002/cncr.23484.

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Kellaris, K. V., S. Bowen, and R. Gilmore. "ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein." Journal of Cell Biology 114, no. 1 (July 1, 1991): 21–33. http://dx.doi.org/10.1083/jcb.114.1.21.

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We have used the homobifunctional cross-linking reagent disuccinimidyl suberate (DSS) to identify proteins that are adjacent to nascent polypeptides undergoing translocations across mammalian rough ER. Translocation intermediates were assembled by supplementing cell free translations of truncated mRNAs with the signal recognition particle (SRP) and microsomal membrane vesicles. Two prominent cross-linked products of 45 and 64 kD were detected. The 64-kD product was obtained when the cell free translation contained SRP, while formation of the 45-kD product required both SRP and translocation competent microsomal membrane vesicles. In agreement with previous investigators, we suggest that the 64-kD product arises by cross-linking of the nascent polypeptide to the 54-kD subunit of SRP. The 45-kD product resists alkaline extraction from the membrane, so we conclude that the 11-kD nascent polypeptide has been crosslinked to an integral membrane protein of approximately 34 kD (imp34). The cross-linked product does not bind to ConA Sepharose, nor is it sensitive to endoglycosidase H digestion; hence imp34 is not identical to the alpha or beta subunits of the signal sequence receptor (SSR). We propose that imp34 functions in concert with SSR to form a translocation site through which nascent polypeptides pass in traversing the membrane bilayer of the rough endoplasmic reticulum.

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Landsman, Miriam J., Kathy Thompson, and Gail Barber. "Using Mediation to Achieve Permanency for Children and Families." Families in Society: The Journal of Contemporary Social Services 84, no. 2 (April 2003): 229–39. http://dx.doi.org/10.1606/1044-3894.100.

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The Iowa Mediation for Permanency Project (IMPP), a nonadversarial mediation-based approach founded on the principles of attachment and empowerment, is a promising way to achieve permanency for children, a national priority in child welfare established by The Adoption and Safe Families Act of 1997. The IMPP broadens the concept of permanency to include reunification and guardianship. The authors discuss its implementation, including qualifications and requirements of mediators, examine an independent evaluation of the results, and present two case histories.

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Lu, Di, Poonam Vohra, Peigou G. Chu, Bruce Woda, Kenneth L. Rock, and Zhong Jiang. "An Oncofetal Protein IMP3." American Journal of Surgical Pathology 33, no. 4 (April 2009): 521–25. http://dx.doi.org/10.1097/pas.0b013e31818aada9.

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Zheng, Wenxin, Xiaofang Yi, Oluwole Fadare, Sharon X. Liang, Maritza Martel, Peter E. Schwartz, and Zhong Jiang. "The Oncofetal Protein IMP3." American Journal of Surgical Pathology 32, no. 2 (February 2008): 304–15. http://dx.doi.org/10.1097/pas.0b013e3181483ff8.

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Tira, Hendry Sakke, Abdul Natsir, and Muhamad Saiful Anwar. "Studi Eksperimental pada Emulator Surya Berdasarkan Intensitas Matahari Terhadap Unjuk Kerja Sel Surya 10 Wp Tipe Polycristalline." ROTASI 19, no. 4 (November 3, 2017): 237. http://dx.doi.org/10.14710/rotasi.19.4.237-242.

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Energi merupakan salah satu kebutuhan utama dalam kehidupan manusia. Peningkatan kebutuhan energi dapat merupakan indikator peningkatan kemakmuran, namun bersamaan dengan itu juga menimbulkan masalah dalam usaha penyediaannya, karena manusia hanya mengandalkan energi fosil yang tentunya persediaannya masih sangat terbatas dan semakin menipis. Indonesia terletak di daerah khatulistiwa sehingga memiliki intensitas penyinaran matahari yang baik sepanjang tahun. Kondisi penyinaran ini potensial untuk digunakan dalam pembangkitan listrik tenaga surya (PLTS). PLTS merupakan teknologi ramah lingkungan yang memanfaatkan energi sel surya fotovoltaik dengan cara mengkonversi energi cahaya yang dipancarkan oleh matahari menjadi energi listrik. Tujuan dari penelitian ini adalah mengetahui pengaruh intensitas cahaya lampu terhadap arus titik daya maksimum (Impp), tegangan titik daya maksimum (Vmpp), daya maksimum power point (Pmpp), dan efisiensi dari panel surya 10 WP tipe polycristalline pada alat solar emulator. Penelitian ini dilakukan dengan merubah intensitas cahaya lampu pada alat solar emulator berdasarkan intensitas cahaya matahari tanggal 17-25 Maret 2016. Berdasarkan penelitian yang telah dilakukan, menunjukkan bahwa intensitas cahaya lampu mempunyai pengaruh terhadap Impp, Vmpp, Pmpp, dan Efisiensi dari panel surya 10 WP tipe polycristalline. Semakin tinggi intensitas cahaya lampu maka semakin tinggi pula nilai Impp, Vmpp, Pmpp, dan efisiensi yang diperoleh. Efisiensi panel surya tertinggi diperoleh pukul 12:00-12:40 WITA pada tanggal 22 Maret 2016 sebesar 4,14 %.

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Tantravahi, Srinivas K., Daniel Albertson, Archana M. Agarwal, Sowmya Ravulapati, Austin Poole, Shiven B. Patel, Jamil S. Hawatmeh, et al. "Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma." Journal of Oncology 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/181926.

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Metastatic renal cell carcinoma with sarcomatoid histology (SmRCC) is associated with poor survival. No data is available from randomized trials on the efficacy of vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) inhibitors in SmRCC. We identified SmRCC patients from a single institutional database. To identify predictive and prognostic biomarkers, immunohistochemistry (IHC) analysis was performed on the tumor samples for downstream targets of VEGF and mTOR pathways. Survival outcomes were stratified by IHC analysis, extent of sarcomatoid component, Memorial Sloan-Kettering Cancer Center (MSKCC), and Heng risk criteria. Twenty-seven patients with SmRCC were included. First line therapy included targeted therapy (n=19), immunotherapy (n=4), cytotoxic chemotherapy (n=1), and no treatment (n=3). Median OS was 8.2 months (95% CI 3.8–14.2 months). Median survival in months, based on MSKCC and Heng risk groups, was favorable 89.3 versus 84.5, intermediate 9.5 versus 12.7, and poor 3.9 versus 5.1. None of the IHC markers predicted outcomes of treatment with VEGF or mTOR inhibitors. Only tumor IMP3 expression was associated with inferior OS, although not statistically significant (IMP3 negative 14.2 versus IMP3 positive 4.9 months; HR 0.46, 95% CI 0.16–1.21;P=0.12). The study was limited by small sample size.

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Aulakh, Kanwaijit S., Cary D. Chisholm, Daniel A. Smith, and V. O. Speights. "TTF-1 and Napsin A Do Not Differentiate Metastatic Lung Adenocarcinomas From Primary Esophageal Adenocarcinomas: Proposal of a Novel Staining Panel." Archives of Pathology & Laboratory Medicine 137, no. 8 (August 1, 2013): 1094–98. http://dx.doi.org/10.5858/arpa.2012-0305-oa.

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Context.—When adenocarcinomas arise within the esophagus, particularly when located away from the gastroesophageal junction, it may be important in some patients to differentiate between a primary esophageal adenocarcinoma and metastasis from another site. Lung adenocarcinoma is one tumor that has been reported to frequently metastasize to the esophagus. Objectives.—To create a panel of immunohistochemical markers that can reliably distinguish between an esophageal and pulmonary primary; within the gastrointestinal pathology literature, including published articles and textbooks, common lung immunohistochemical markers, such as TTF-1, are assumed to be negative in esophageal adenocarcinoma, yet, to our knowledge, no study has yet investigated the veracity of that presumption. Design.—In this study, 24 cases each of pulmonary and esophageal adenocarcinomas were stained with TTF-1, napsin A, CDX2, 34βE12, N-cadherin, and IMP3 in an attempt to define an optimal panel for differentiation. Esophageal adenocarcinomas occurring at the gastroesophageal junction were excluded in this study because a gastric primary tumor cannot be excluded in those cases. Results.—Surprisingly, TTF-1 and napsin A were positive in similar proportions of tumors from both sites. Those markers that differentiated statistically between esophageal and pulmonary adenocarcinoma were IMP3, CDX2, and N-cadherin. Conclusions.—When differentiating the origin of a tumor as either esophageal or pulmonary, an immunohistochemical panel consisting of IMP3, CDX2, and N-cadherin is superior to either TTF-1 or napsin A.

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Harthimmer, Mads Rohde, Uffe Stolborg, Per Pfeiffer, Michael Bau Mortensen, Claus Fristrup, and Sönke Detlefsen. "Mutational profiling and immunohistochemical analysis of a surgical series of ampullary carcinomas." Journal of Clinical Pathology 72, no. 11 (June 29, 2019): 762–70. http://dx.doi.org/10.1136/jclinpath-2019-205912.

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AimsKnowledge regarding the genetic features of ampullary carcinoma (AC) in European patients is limited. The utility of tumour markers for the establishment of a malignant diagnosis in biopsies from the ampullary region has not been fully elucidated. We aimed to describe the clinical, pathological, immunohistochemical (IHC) and genetic features of a Danish series of surgically resected ACs.MethodsSurgically resected ACs (n=59) were examined regarding (1) clinicopathological features, (2) histological subtypes, (3) expression of IMP3, maspin, MUC5AC and S100P and (4) next-generation sequencing using a hybrid capture-based platform (Illumina HiSeq2500), including 315 cancer-related genes plus introns from 28 genes often rearranged or altered in cancer. Tumour mutational burden (TMB) and microsatellite instability (MSI) were also evaluated.ResultsPancreatobiliary adenocarcinomas (PB-AC), intestinal adenocarcinomas (INT-AC), other ampullary tumours and mixed adenocarcinomas represented 45.8%, 23.7%, 16.9% and 13.6%. The proportion of IHC-positive ACs (score ≥2) was: Maspin (94.9%), IMP3 (67.8%), S100P (39.0%) and MUC5AC (18.6%). Most frequently altered genes were TP53 (59.3%), KRAS (40.7%), APC (27.8%), SMAD4 (20.4%), CDKN2A (16.7%) and ARID2/PIK3CA (each 11.1%). MUC5AC and S100P were frequently expressed in PB-AC, APC alterations frequent in INT-AC, SOX9 alterations were exclusive in INT-AC and MDM2 and FRS2 alterations in PB-AC. Four of 49 ACs (8.2%) were TMB-high/MSI-high and showed loss of MLH1 and PMS2.ConclusionsPB-AC was the most frequent histological subtype of AC. Maspin and IMP3 were the IHC tumour markers with the highest sensitivity. Adenocarcinoma subtypes differed regarding several genetic alterations, whose predictive value remains to be evaluated.

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An, Ming-Xin, Si Li, Han-Bing Yao, Chao Li, Jia-Mei Wang, Jia Sun, Xin-Yu Li, Xiao-Na Meng, and Hua-Qin Wang. "BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells." Journal of Cell Biology 216, no. 12 (November 7, 2017): 4091–105. http://dx.doi.org/10.1083/jcb.201701064.

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Aerobic glycolysis, a phenomenon known historically as the Warburg effect, is one of the hallmarks of cancer cells. In this study, we characterized the role of BAG3 in aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) and its molecular mechanisms. Our data show that aberrant expression of BAG3 significantly contributes to the reprogramming of glucose metabolism in PDAC cells. Mechanistically, BAG3 increased Hexokinase 2 (HK2) expression, the first key enzyme involved in glycolysis, at the posttranscriptional level. BAG3 interacted with HK2 mRNA, and the degree of BAG3 expression altered recruitment of the RNA-binding proteins Roquin and IMP3 to the HK2 mRNA. BAG3 knockdown destabilized HK2 mRNA via promotion of Roquin recruitment, whereas BAG3 overexpression stabilized HK2 mRNA via promotion of IMP3 recruitment. Collectively, our results show that BAG3 promotes reprogramming of glucose metabolism via interaction with HK2 mRNA in PDAC cells, suggesting that BAG3 may be a potential target in the aerobic glycolysis pathway for developing novel anticancer agents.

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Yildirim, Hulya Tosun, and Nilay Senturk. "Analysis of imp3 expression in prostate adenocarcinomas." Turkish Journal of Pathology 28, no. 2 (2012): 128. http://dx.doi.org/10.5146/tjpath.2012.01111.

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Gong, Yuna, Bruce A. Woda, and Zhong Jiang. "Oncofetal Protein IMP3, a New Cancer Biomarker." Advances In Anatomic Pathology 21, no. 3 (May 2014): 191–200. http://dx.doi.org/10.1097/pap.0000000000000021.

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Kessler, Jonathan M., Anthony Kovacs, Huawen Lin, Susan Dutcher, and Yan Mei Wang. "Intraflagellar Transport Inhomogeneity in Chlamydomonas IMP3 Mutant." Biophysical Journal 106, no. 2 (January 2014): 362a. http://dx.doi.org/10.1016/j.bpj.2013.11.2055.

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Sidoni, Angelo, and Fabio Cartaginese. "IMP3 expression in triple-negative breast carcinoma." Human Pathology 41, no. 9 (September 2010): 1355–56. http://dx.doi.org/10.1016/j.humpath.2010.05.004.

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Shamachurn, Heman, and Thomas Betts. "Experimental Study of the Degradation of Silicon Photovoltaic Devices under Ultraviolet Radiation Exposure." Journal of Solar Energy 2016 (July 31, 2016): 1–9. http://dx.doi.org/10.1155/2016/2473245.

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This paper presents an analysis of the effects of ultraviolet (UV) exposure on amorphous silicon (a-Si), bare crystalline silicon (c-Si), and epoxy resin encapsulated c-Si devices. The long-term reliability of photovoltaic (PV) modules is crucial in ensuring the viability of PV as a successful source of energy. Accelerated UV ageing methods are required to quickly evaluate the UV durability of module materials. A UV exposure unit was designed and constructed and provided an average of 45.7 W/m2 of UV irradiance over the exposure area with a nonuniformity of 14.9%. The a-Si devices lost up to 44% of maximum power (Pmax) at Standard Test Conditions over 500 hours of exposure to UV, with maximum losses of 11% in short-circuit current (Isc), 11% in open-circuit voltage (Voc), 23% in voltage at Pmax (Vmpp), and 29% in current at Pmax (Impp). The epoxy resin encapsulated samples lost up to 6.4% in Pmax, 6% in Isc, and 7% in Impp with the changes in Voc and Vmpp being random. The bare cells showed relatively little degradation. UV radiation thus accelerates the degradation of a-Si devices, deteriorates polymeric encapsulates of modules, and possibly affects the antireflective coatings applied on solar cells.

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EL-BALAT, AHMED, NICOLE SÄNGER, THOMAS KARN, SVEN BECKER, UWE HOLTRICH, ZELAL MUALLEM, and RUZA ARSENIC. "IMP3 Expression in Borderline Tumors of the Ovary." Anticancer Research 37, no. 2 (February 10, 2017): 583–88. http://dx.doi.org/10.21873/anticanres.11351.

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Chennapragada, Srilakshmi, Mahtab Farzin, and Anthony J. Gill. "An analysis of IMP3 expression in lung cancer." Pathology 44 (2012): S72—S73. http://dx.doi.org/10.1016/s0031-3025(16)32791-x.

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Jia, Min, Heinz Gut, and Jeffrey A. Chao. "Structural basis of IMP3 RRM12 recognition of RNA." RNA 24, no. 12 (August 22, 2018): 1659–66. http://dx.doi.org/10.1261/rna.065649.118.

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Jin, Long, Amber R. Seys, Shuya Zhang, Michele R. Erickson-Johnson, Christopher W. Roth, Barbara R. Evers, Andre M. Oliveira, and Ricardo V. Lloyd. "Diagnostic Utility of IMP3 Expression in Thyroid Neoplasms." Diagnostic Molecular Pathology 19, no. 2 (June 2010): 63–69. http://dx.doi.org/10.1097/pdm.0b013e3181b6a528.

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Beljan Perak, Renata, Merica Durdov, Vesna Capkun, Veljka Ivcevic, Antonia Pavlovic, Violeta Soljic, and Mari Peric. "IMP3 can predict aggressive behaviour of lung adenocarcinoma." Diagnostic Pathology 7, no. 1 (2012): 165. http://dx.doi.org/10.1186/1746-1596-7-165.

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Yeap, Isobel, Jessica Mills, Lucinda Mylchreest, Aditi Raut, and Anthony J. Gill. "18. IMP3 expression in triple-negative breast cancer." Pathology 47 (2015): S106. http://dx.doi.org/10.1097/01.pat.0000461627.59299.f5.

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Chisté, Marcela, John Alexis, and Monica Recine. "IMP3 Expression in Serous Tumors of the Ovary." Applied Immunohistochemistry & Molecular Morphology 22, no. 9 (October 2014): 658–62. http://dx.doi.org/10.1097/pai.0000000000000021.

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42

Bellezza, Guido, Antonio Cavaliere, and Angelo Sidoni. "IMP3 expression in non–small cell lung cancer." Human Pathology 40, no. 8 (August 2009): 1205–6. http://dx.doi.org/10.1016/j.humpath.2009.03.019.

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Khan, Ashraf, and Otto Walter. "IMP3 expression in triple-negative breast carcinoma - Reply." Human Pathology 41, no. 9 (September 2010): 1356–57. http://dx.doi.org/10.1016/j.humpath.2010.05.005.

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Kumara H, C. M. Shantha, Otavia L. Caballero, Su Tao, Aqeel Ahmed, Vesna Cekic, Sacha Gnjatic, Andrew J. Simpson, Carlos Cordon-Cardo, and Richard L. Whelan. "T1635 Expression of the Cancer Testis Antigen IGF2BP3 (IMP3) in Colorectal Cancers; IMP3 Holds Promise as a Specific Immunotherapy Target." Gastroenterology 138, no. 5 (May 2010): S—883—S—884. http://dx.doi.org/10.1016/s0016-5085(10)64082-6.

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Ikeda, Katsuhide, Genshu Tate, Takao Suzuki, Takashi Kitamura, and Toshiyuki Mitsuya. "IMP3/L523S, a novel immunocytochemical marker that distinguishes benign and malignant cells: the expression profiles of IMP3/L523S in effusion cytology." Human Pathology 41, no. 5 (May 2010): 745–50. http://dx.doi.org/10.1016/j.humpath.2009.04.030.

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46

Burnett, Atuhani S., Joanelle Bailey, Joseph B. Oliver, Sushil Ahalawat, and Ravi J. Chokshi. "Sensitivity of cytology and immunohistochemistry for diagnosis of pancreaticobiliary cancer." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): TPS490. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.tps490.

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TPS490 Background: Biliary strictures present a diagnostic challenge to differentiate benign disease from hepatopancreaticobiliary (HPB) malignancies. ERCP cytology is commonly performed in these patients; however, its sensitivity for diagnosis of HPB malignancy is poor (41.6%). Many adjunctive tests have been investigated to improve the sensitivity of HPB biopsies. In a recent meta-analysis by our group the best immunohistochemical (IHC) stains were a combination of IMP3, S100A4, and standard cytology. IHC stains for S100P and pVHL negativity were also helpful. Based on this meta-analysis we have designed a retrospective analysis of old cell block specimens to demonstrate the sensitivity and specificity of a combination IHC staining panel in detecting HPB maliganancies. Methods: Retrospective IHC staining will be carried out on old cell blocks from ERCP brushings and EUS-FNA. Expression of IMP3, S100A4, S100P, and pVHL will be determined. Using this panel as a combination we will determine its sensitivity and specificity on 200 patient samples. We will further determine how many stains are necessary to achieve maximum sensitivity by subtraction of data from one or more IHC stains followed by repeating sensitivity calculations. Finally, we will calculate the cost of conducting these tests and determine the cost-benefit ratio of employing these tests in the wider clinical setting. Conclusions: Overall we feel these studies will advance the precision with which clinicians can determine the presence of HPB malignancy in patients undergoing biopsy. This will ultimately lead to fewer patients with benign disease undergoing resection unnecessarily.

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Xu, Haodong. "IMP3: a diagnostic and prognostic biomarker in malignant melanoma." Expert Review of Molecular Diagnostics 8, no. 5 (September 2008): 557–58. http://dx.doi.org/10.1586/14737159.8.5.557.

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Ozdemir, Nihal Ozkalay, Nilay Sen Turk, and Ender Duzcan. "Imp3 expression in urothelial carcinomas of the urinary bladder." Turkish Journal of Pathology 27, no. 1 (2011): 31. http://dx.doi.org/10.5146/tjpath.2010.01044.

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Maržić, Diana, Miran Čoklo, Blažen Marijić, Ita Hadžisejdić, Andrea Dekanić, Mira Krstulja, Tatjana Šepić, Manuela Avirović, and Tamara Braut. "The expression of ribonuclear protein IMP3 in laryngeal carcinogenesis." Pathology - Research and Practice 216, no. 6 (June 2020): 152974. http://dx.doi.org/10.1016/j.prp.2020.152974.

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Post, M. D. "Oncofetal protein IMP3: a useful diagnostic biomarker for leiomyosarcoma." Yearbook of Pathology and Laboratory Medicine 2013 (January 2013): 169–71. http://dx.doi.org/10.1016/j.ypat.2012.11.086.

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