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Journal articles on the topic 'Impact de plaques'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2025

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1

Barrett, Hilary E., Kim Van der Heiden, Eric Farrell, Frank J. H. Gijsen, and Ali C. Akyildiz. "Calcifications in atherosclerotic plaques and impact on plaque biomechanics." Journal of Biomechanics 87 (April 2019): 1–12. http://dx.doi.org/10.1016/j.jbiomech.2019.03.005.

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Wendorff, Carina, Heiko Wendorff, Andreas Kuehnl, et al. "Impact of sex and age on carotid plaque instability in asymptomatic patients-results from the Munich Vascular Biobank." Vasa 45, no. 5 (2016): 411–16. http://dx.doi.org/10.1024/0301-1526/a000557.

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Abstract. Background: It is still a controversial issue whether carotid endarterectomy (CEA) for asymptomatic carotid stenosis is superior to best medical treatment. The aim of this study was therefore to analyze the impact of sex and age on carotid plaque instability in asymptomatic patients undergoing CEA. Patients and methods: Atherosclerotic plaques from 465 asymptomatic patients with high-grade carotid artery stenosis (2004 - 2013) at the Munich Vascular Biobank were analyzed. Ascertainment of lesion stability/instability was performed on formalin-fixed paraffin-embedded tissue samples us

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3

Hirata, Yoko, Noriyuki Sakata, Tooru Inoue, Kotaro Yasumori, Masahiro Yasaka, and Yasushi Okada. "Histopathological features with angiographic correlates of internal carotid artery pseudo-occlusion: impact of plaque compositions." Journal of Neurosurgery 115, no. 2 (2011): 350–58. http://dx.doi.org/10.3171/2011.3.jns101434.

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Object This study describes clinicopathological characteristics of pseudo-occlusion of the internal carotid artery with regard to its possible mechanisms. Methods The authors retrospectively reviewed 17 patients with pseudo-occlusion and 23 with high-grade stenosis (North American Symptomatic Carotid Endarterectomy Trial criteria ≥ 90%, but no collapsed distal internal carotid artery) who underwent carotid endarterectomy. Atherosclerotic risk factors, clinical presentation, angiographic findings, and histological features of plaque obtained from the carotid endarterectomy were investigated and

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Puylaert, Pauline, Isabelle Coornaert, Cédric H. G. Neutel, et al. "The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach." Biomedicines 10, no. 5 (2022): 1016. http://dx.doi.org/10.3390/biomedicines10051016.

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RIPK1 (receptor-interacting serine/threonine-protein kinase 1) enzymatic activity drives both apoptosis and necroptosis, a regulated form of necrosis. Because necroptosis is involved in necrotic core development in atherosclerotic plaques, we investigated the effects of a RIPK1S25D/S25D mutation, which prevents activation of RIPK1 kinase, on atherogenesis in ApoE−/− mice. After 16 weeks of western-type diet (WD), atherosclerotic plaques from ApoE−/− RIPK1S25D/S25D mice were significantly larger compared to ApoE−/− RIPK1+/+ mice (167 ± 34 vs. 78 ± 18 × 103 µm2, p = 0.01). Cell numbers (350 ± 34

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Wang, Bo, Xitan Hou, Yaning Sun, et al. "Interleukin-17A influences the vulnerability rather than the size of established atherosclerotic plaques in apolipoprotein E-deficient mice." Open Life Sciences 17, no. 1 (2022): 1104–15. http://dx.doi.org/10.1515/biol-2022-0072.

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Abstract Interleukin (IL)-17A plays a role in the development of atherosclerotic plaques; however, the mechanism remains unclear. In this study, apolipoprotein E-deficient (ApoE–/–) mice were fed a high-fat diet to induce atherosclerosis, followed by the treatment with exogenous recombinant IL-17A or the neutralizing antibody to confirm the impact of IL-17A on the established atherosclerotic plaques. We found that both the stimulation of IL-17A and blockage of endogenous IL-17 via antibody did not affect the size of the established plaques. However, IL-17A significantly increased the vulnerabi

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Peiu, Sorin Nicolae, Diana Gabriela Iosep, Mihai Danciu, Veronica Scripcaru, Victor Ianole, and Veronica Mocanu. "Ghrelin Expression in Atherosclerotic Plaques and Perivascular Adipose Tissue: Implications for Vascular Inflammation in Peripheral Artery Disease." Journal of Clinical Medicine 13, no. 13 (2024): 3737. http://dx.doi.org/10.3390/jcm13133737.

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Atherosclerosis, a leading cause of peripheral artery disease (PAD), is driven by lipid accumulation and chronic inflammation within arterial walls. Objectives: This study investigates the expression of ghrelin, an anti-inflammatory peptide hormone, in plaque morphology and inflammation in patients with PAD, highlighting its potential role in age-related vascular diseases and metabolic syndrome. Methods: The analysis specifically focused on the immunohistochemical expression of ghrelin in atherosclerotic plaques and perivascular adipose tissue (PVAT) from 28 PAD patients. Detailed immunohistoc

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Mouzakis, Dionysios E., Tapio Harmia, and József Karger-Kocsis. "Fracture Behaviour of Discontinuous Long Glass Fibre Reinforced Injection Moulded Polypropylene." Polymers and Polymer Composites 8, no. 3 (2000): 167–75. http://dx.doi.org/10.1177/0967391120000803167.

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The in- and out-of-plane fracture behaviour of injection-moulded discontinuous long glass fibre reinforced (DLGF) polypropylene composites (PP) as stu.died. The DLGF content (0-11 wt%) and thickness of the molded plaques were vaned. The m-plane fracture toughness, as assessed by the essential work of fracture (EWF) method, showed a clear anisotropy. This was explained by the effects of the DLGF orientation and distribution. confirmed by fractography. The out-of-plane instrumented falling weight impact (IFWI) toughness ofthe 4 mm thick plaques was higher than that of the 2 mm thick ones. This w

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8

Seime, Till, Max van Wanrooij, Eva Karlöf, et al. "Biomechanical Assessment of Macro-Calcification in Human Carotid Atherosclerosis and Its Impact on Smooth Muscle Cell Phenotype." Cells 11, no. 20 (2022): 3279. http://dx.doi.org/10.3390/cells11203279.

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Intimal calcification and vascular stiffening are predominant features of end-stage atherosclerosis. However, their role in atherosclerotic plaque instability and how the extent and spatial distribution of calcification influence plaque biology remain unclear. We recently showed that extensive macro calcification can be a stabilizing feature of late-stage human lesions, associated with a reacquisition of more differentiated properties of plaque smooth muscle cells (SMCs) and extracellular matrix (ECM) remodeling. Here, we hypothesized that biomechanical forces related to macro-calcification wi

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9

Ulrich, Jason D., Tyler K. Ulland, Thomas E. Mahan, et al. "ApoE facilitates the microglial response to amyloid plaque pathology." Journal of Experimental Medicine 215, no. 4 (2018): 1047–58. http://dx.doi.org/10.1084/jem.20171265.

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One of the hallmarks of Alzheimer’s disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-β (Aβ) peptide. Apolipoprotein E (ApoE) influences the deposition of amyloid pathology through affecting the clearance and aggregation of monomeric Aβ in the brain. In addition to influencing Aβ metabolism, increasing evidence suggests that apoE influences microglial function in neurodegenerative diseases. Here, we characterize the impact that apoE has on amyloid pathology and the innate immune response in APPPS1ΔE9 and APPPS1-21 transgenic mice. We

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Grootaert, Mandy O. J., Dorien M. Schrijvers, Marthe Hermans, Viviane O. Van Hoof, Guido R. Y. De Meyer, and Wim Martinet. "Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3087469.

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Apoptosis of macrophages and vascular smooth muscle cells (VSMCs) in advanced atherosclerotic plaques contributes to plaque progression and instability. Caspase-3, a key executioner protease in the apoptotic pathway, has been identified in human and mouse atherosclerotic plaques but its role in atherogenesis is not fully explored. We therefore investigated the impact of caspase-3 deletion on atherosclerosis by crossbreeding caspase-3 knockout (Casp3−/−) mice with apolipoprotein E knockout (ApoE−/−) mice. Bone marrow-derived macrophages and VSMCs isolated from Casp3−/−ApoE−/−mice were resistant

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Hirayama, Kenshi, Hideki Ishii, Ryosuke Kikuchi, et al. "Clinical Impact of Circulating Irisin on Classified Coronary Plaque Characteristics." Journal of Applied Laboratory Medicine 3, no. 1 (2018): 79–88. http://dx.doi.org/10.1373/jalm.2017.025296.

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Abstract Background Myokines are hormones secreted by skeletal muscles during physical activity. Low myokine levels may contribute to metabolic dysfunction and cardiovascular disorders. Irisin, a newly identified myokine, has been the focus of recent research. The aim of the present study was to analyze the association between circulating irisin levels and tissue characteristics of nonculprit left main coronary artery (LMCA) plaques with the use of integrated backscatter (IB) intravascular ultrasound (IVUS). Methods This observational study enrolled 55 Japanese patients following successful pe

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Lamberti, Giuseppe, Francesco Gelsomino, Stefano Brocchi, et al. "New disappearance of complicated atheromatous plaques on rechallenge with PD-1/PD-L1 axis blockade in non-small cell lung cancer patient: follow up of an unexpected event." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592091380. http://dx.doi.org/10.1177/1758835920913801.

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Atherosclerosis is considered an irreversible process, with crucial contribution of inflammation and immune cells. Impact of cancer immunotherapy on a partly immune-driven disease, such as atherosclerosis, is poorly understood, but preclinical models suggest its worsening on programmed death/ligand-1 (PD-1/PD-L1) inhibitors. In a previously reported cohort of 11 patients with non-small cell lung cancer (NSCLC) treated with nivolumab and pre-existing complicated atheromatous plaques, 3 patients had a dramatic radiologic reduction of aortic plaques while on nivolumab; of these 3, 2 died receivin

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Wang, Qingyu, Dalin Tang, Gador Canton, et al. "Impact of Patient-Specific In Vivo Vessel Material Properties on Carotid Atherosclerotic Plaque Stress/Strain Calculations." International Journal of Computational Methods 16, no. 03 (2019): 1842002. http://dx.doi.org/10.1142/s0219876218420021.

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Patient-specific vessel material properties are in general lacking in image-based computational models. Carotid plaque stress and strain conditions with in vivo material and old material models were investigated (8 patients, 16 plaques). Plaque models using patient-specific in vivo vessel material properties showed significant differences from models using old material properties from the literature on stress and strain calculations. These differences demonstrated that models using in vivo material properties could improve the accuracy of stress and strain calculations which could potentially

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Maroto-Morales, Daniel, Trinidad Montero-Vilchez, and Salvador Arias-Santiago. "Study of Skin Barrier Function in Psoriasis: The Impact of Emollients." Life 11, no. 7 (2021): 651. http://dx.doi.org/10.3390/life11070651.

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Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier. Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective of this study is to evaluate the effect of Vaseline jelly and a water-based formula on epidermal barrier function in psoriatic patients. Thirty-one patients with plaque-type psoriasis and thirty-one gender and age-matched healthy controls were enrolled in the study. Temperature, transepidermal water loss

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15

Chu, Tak-Ho, Karen Cummins, and Peter K. Stys. "Traumatic Injury Reduces Amyloid Plaque Burden in the Transgenic 5xFAD Alzheimer’s Mouse Spinal Cord." Journal of Alzheimer's Disease 77, no. 3 (2020): 1315–30. http://dx.doi.org/10.3233/jad-200387.

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Background: Axonal injury has been implicated in the development of amyloid-β in experimental brain injuries and clinical cases. The anatomy of the spinal cord provides a tractable model for examining the effects of trauma on amyloid deposition. Objective: Our goal was to examine the effects of axonal injury on plaque formation and clearance using wild type and 5xFAD transgenic Alzheimer’s disease mice. Methods: We contused the spinal cord at the T12 spinal level at 10 weeks, an age at which no amyloid plaques spontaneously accumulate in 5xFAD mice. We then explored plaque clearance by impacti

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Kłosowicz, Maksymilian, Dawid Leksa, Dorota Bartusik-Aebisher, Angelika Myśliwiec, Klaudia Dynarowicz, and David Aebisher. "Biomarkers That Seem to Have the Greatest Impact on Promoting the Formation of Atherosclerotic Plaque in Current Scientific Research." Current Issues in Molecular Biology 46, no. 9 (2024): 9503–22. http://dx.doi.org/10.3390/cimb46090564.

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Atherosclerosis is a chronic inflammatory disease that causes degenerative and productive changes in the arteries. The resulting atherosclerotic plaques restrict the vessel lumen, causing blood flow disturbances. Plaques are formed mainly in large- and medium-sized arteries, usually at bends and forks where there is turbulence in blood flow. Depending on their location, they can lead to various disease states such as myocardial infarction, stroke, renal failure, peripheral vascular diseases, or sudden cardiac death. In this work, we reviewed the literature on the early detection of atheroscler

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Zheng, Fei, Shanshan Xing, Zushun Gong, Wei Mu, and Qichong Xing. "Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice." Mediators of Inflammation 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/507208.

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Objectives. The role of the NLRP3 inflammasome in atherosclerosis remains controversial. The aim of this study was to determine whether inhibition of NLRP3 signaling by lentivirus-mediated RNA interference could reduce atherosclerosis and stabilizes plaques. We also tried to explore the mechanisms of the impact of NLRP3 inflammasome on atherosclerosis.Methods. Apolipoprotein E-deficient mice aged 8 weeks were fed a high-fat diet and were injected with NLRP3 interfering or mock viral suspension after 4 weeks. Lentivirus transfer was repeated in 2 weeks. Four weeks after the first lentivirus inj

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Brinjikji, Waleed, Alejandro A. Rabinstein, Giuseppe Lanzino, et al. "Ultrasound Characteristics of Symptomatic Carotid Plaques: A Systematic Review and Meta-Analysis." Cerebrovascular Diseases 40, no. 3-4 (2015): 165–74. http://dx.doi.org/10.1159/000437339.

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Background: Ultrasound is the most commonly used imaging modality for assessing carotid artery stenosis. A number of studies have demonstrated that surface irregularities, heterogeneous echotexture and hypoechoic plaques are risk factors for acute ischemic stroke. We performed a systematic review and meta-analysis of the literature to better define the risk of stroke based on the sonographic characteristics of carotid plaques. Materials and Methods: We performed a comprehensive search for studies reporting imaging findings of symptomatic and asymptomatic carotid plaques on ultrasound using MED

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Drysdale, Amelia, Amanda J. Unsworth, Stephen J. White, and Sarah Jones. "The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications." International Journal of Molecular Sciences 24, no. 14 (2023): 11854. http://dx.doi.org/10.3390/ijms241411854.

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The vascular extracellular matrix (ECM) produced by endothelial and smooth muscle cells is composed of collagens and glycoproteins and plays an integral role in regulating the structure and function of the vascular wall. Alteration in the expression of these proteins is associated with endothelial dysfunction and has been implicated in the development and progression of atherosclerosis. The ECM composition of atherosclerotic plaques varies depending on plaque phenotype and vulnerability, with distinct differences observed between ruptured and erodes plaques. Moreover, the thrombi on the expose

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Liu, J., J. J. Chen, X. N. Zhao, and H. Z. Zhang. "SPATIAL DIFFERENTIATION CHARACTERISTICS OF ALPINE GRASSLAND PATCHES IN THE SOURCE REGION OF THE YELLOW RIVER AND ITS ECOLOGICAL SIGNIFICANCE." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-3/W10 (February 8, 2020): 755–62. http://dx.doi.org/10.5194/isprs-archives-xlii-3-w10-755-2020.

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Abstract. The source region of the Yellow River is an important source of water conservation in the Qinghai-Tibet Plateau. It is also an animal husbandry base that has a major impact on China. Its ecological environment changes will have a major impact on the safe and sustainable development of water use in Asia. The alpine grassland is an important part of the ecosystem of the Yellow River source area, and the spatial differentiation characteristics of the plaque have important indication significance for the ecological environment succession. In this paper, the alpine grassland in the source

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MacAskill, Mark G., David E. Newby, and Adriana A. S. Tavares. "Frontiers in positron emission tomography imaging of the vulnerable atherosclerotic plaque." Cardiovascular Research 115, no. 14 (2019): 1952–62. http://dx.doi.org/10.1093/cvr/cvz162.

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AbstractRupture of vulnerable atherosclerotic plaques leading to an atherothrombotic event is the primary driver of myocardial infarction and stroke. The ability to detect non-invasively the presence and evolution of vulnerable plaques could have a huge impact on the future identification and management of atherosclerotic cardiovascular disease. Positron emission tomography (PET) imaging with an appropriate radiotracer has the potential to achieve this goal. This review will discuss the biological hallmarks of plaque vulnerability before going on to evaluate and to present PET imaging approach

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Espinosa, Ch, and F. Collombet. "Impact de plaques composites : caractérisation et modèles." Journal de Physique III 1, no. 12 (1991): 1953–68. http://dx.doi.org/10.1051/jp3:1991242.

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Mukherjee, Pronoy, Aloke Saha, Tanmay Sanyal, and Koushik Sen. "Inhibition of secretase: A promising technique for Alzheimer’s disease patients." International Journal of Advanced Research Trends in Science 2, no. 1 (2023): 31–35. http://dx.doi.org/10.70035/ijarts.2023.2131-35.

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Alzheimer’s is a globally known neurodegenerative disease. Aβ is a cleavage product of the 695-770 amino acid, single mem-brane-spanning protein known as the Aβ-precursor protein (APP), which is highly expressed in the nervous system. The most abundantly produced isoform of A by neurons is A40, while A42 has two C-terminal hydrophobic residues that increase its propensity to self-assemble into amyloid. As a consequence, despite differences in the relative numbers of plaques stained for A40 and A42, more plaques are immunoreactive for A42 than for A40. In addition to plaques and amyloid angiopa

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Mátyás, Botond Barna, Imre Benedek, Nóra Raț, et al. "Assessing the Impact of Long-Term High-Dose Statin Treatment on Pericoronary Inflammation and Plaque Distribution—A Comprehensive Coronary CTA Follow-Up Study." International Journal of Molecular Sciences 25, no. 3 (2024): 1700. http://dx.doi.org/10.3390/ijms25031700.

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Computed tomography angiography (CTA) has validated the use of pericoronary adipose tissue (PCAT) attenuation as a credible indicator of coronary inflammation, playing a crucial role in coronary artery disease (CAD). This study aimed to evaluate the long-term effects of high-dose statins on PCAT attenuation at coronary lesion sites and changes in plaque distribution. Our prospective observational study included 52 patients (mean age 60.43) with chest pain, a low-to-intermediate likelihood of CAD, who had documented atheromatous plaque through CTA, performed approximately 1 year and 3 years aft

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Vesa, Stefan Cristian, Sonia Irina Vlaicu, Vitalie Vacaras, et al. "CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation." Genes 11, no. 7 (2020): 822. http://dx.doi.org/10.3390/genes11070822.

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Introduction: Atherosclerosis represents the process by which fibrous plaques are formed in the arterial wall, increasing its rigidity with a subsequent decrease in blood flow which can lead to several cardiovascular events. Seeing as vitamin K antagonists are involved in the pathogenesis of atherosclerosis, we decided to investigate whether polymorphisms in genes that influence vitamin K metabolism might have an impact in modulating the risk of plaque formation. Patients and Methods: In the current study we included adult patients admitted in the Clinical Municipal Hospital of Cluj-Napoca wit

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Shrestha, Elina, Maud Voisin, Tessa J. Barrett, et al. "2290." Journal of Clinical and Translational Science 1, S1 (2017): 5. http://dx.doi.org/10.1017/cts.2017.34.

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OBJECTIVES/SPECIFIC AIMS: Accumulation of cholesterol-laden macrophages in arterial walls leads to atherosclerosis. LXRs induce expression of genes that are atheroprotective in macrophages including CCR7, a chemokine receptor that promotes their emigration from the plaque. CCR7 expression has been shown to be negatively regulated by phosphorylation of LXRα at S198 and is reduced in diabetic mice that show impaired plaque regression. I hypothesized that LXRα phosphorylation at S198 diminishes macrophage emigration from atherosclerotic plaque and contributes to impaired regression in diabetes. M

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Dempsey, Robert J., Raghu Vemuganti, Tomy Varghese, and Bruce P. Hermann. "A Review of Carotid Atherosclerosis and Vascular Cognitive Decline." Neurosurgery 67, no. 2 (2010): 484–94. http://dx.doi.org/10.1227/01.neu.0000371730.11404.36.

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Abstract This review encourages the reader to consider cerebral vascular disease beyond the traditional clinical end points of major motor and speech strokes and to consider the possible impact of embolic cerebral vascular disease on vascular cognitive decline. This article examines the issue of “silent” strokes in the relationship between the structural stability of atherosclerotic carotid plaque and the development of nonmotor symptomatology, including cognitive decline. It addresses the question of the role of carotid emboli in silent stroke and their cognitive sequelae. In a study of endar

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Bode, C., and C. von zur Mühlen. "MRI, the technology for imaging of thrombi and inflammation." Hämostaseologie 35, no. 03 (2015): 252–62. http://dx.doi.org/10.5482/hamo-14-11-0061.

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SummaryAtherosclerosis and its sequelae have a major impact on morbidity and mortality. The rupture of an inflamed atherosclerotic plaque is a crucial event, since it can result in acute thrombotic closure of an arterial vessel, resulting e. g. in myocardial infarction or stroke. Not only detection of early plaque rupture with imminent closure is therefore of clinical interest, but also timely detection of vascular inflammation and atherosclerotic plaque progression. However, plaque inflammation or even plaque rupture without vessel occlusion is not reliably detectable by current imaging techn

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Karpouzas, G., S. Ormseth, E. Hernandez, and M. Budoff. "POS0216 GREATER HIGH-DENSITY LIPOPROTEIN LEVELS OVER TIME ARE LINKED TO DECREASED CORONARY PLAQUE FORMATION AND REGRESSION AND STABILIZATION OF HIGH-RISK LESIONS IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 325.2–326. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3383.

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Background:The relationship between serum lipoproteins and cardiovascular disease risk in rheumatoid arthritis (RA) is complex1. Their levels and function may vary based on disease activity and medication use. Beneficial effects on high-density lipoprotein (HDL-C) levels, structure and behavior, in response to treatment have been described. However, the impact of HDL-C levels over time on coronary atherosclerosis progression in RA is unknown.Objectives:We here evaluated the influence of HDL-C levels over time on long-term coronary plaque formation and progression in patients with RA.Methods:On

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Karpouzas, G., B. Papotti, S. Ormseth, et al. "AB0294 INFLAMMATION AND IMMUNOMODULATORY THERAPIES INFLUENCE THE RELATIONSHIP BETWEEN ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-MEDIATED CHOLESTEROL EFFLUX AND CORONARY ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1329. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2070.

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BackgroundCholesterol efflux capacity (CEC) measures the ability of high-density lipoprotein (HDL) to remove cholesterol from atherosclerotic plaques. It is mediated by various membrane transporters exporting cholesterol to HDL particles based on their maturation. It is unclear whether CEC associates with coronary atherosclerosis independently of HDL-C levels in RA or whether CEC itself or its impact on atherogenesis are influenced by inflammation or RA-specific therapies. Conventional and biologic DMARDs are atheroprotective while corticosteroids are proatherogenic. ATP-binding-cassette membr

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Munteanu, Constantin, Anca Irina Galaction, Mădălina Poștaru, Mariana Rotariu, Marius Turnea, and Corneliu Dan Blendea. "Hydrogen Sulfide Modulation of Matrix Metalloproteinases and CD147/EMMPRIN: Mechanistic Pathways and Impact on Atherosclerosis Progression." Biomedicines 12, no. 9 (2024): 1951. http://dx.doi.org/10.3390/biomedicines12091951.

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Atherosclerosis is a chronic inflammatory condition marked by endothelial dysfunction, lipid accumulation, inflammatory cell infiltration, and extracellular matrix (ECM) remodeling within arterial walls, leading to plaque formation and potential cardiovascular events. Key players in ECM remodeling and inflammation are matrix metalloproteinases (MMPs) and CD147/EMMPRIN, a cell surface glycoprotein expressed on endothelial cells, vascular smooth muscle cells (VSMCs), and immune cells, that regulates MMP activity. Hydrogen sulfide (H₂S), a gaseous signaling molecule, has emerged as a significant

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Prokop, Stefan, Kelly R. Miller, Natalia Drost та ін. "Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice". Journal of Experimental Medicine 212, № 11 (2015): 1811–18. http://dx.doi.org/10.1084/jem.20150479.

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Although central nervous system–resident microglia are believed to be ineffective at phagocytosing and clearing amyloid-β (Aβ), a major pathological hallmark of Alzheimer’s disease (AD), it has been suggested that peripheral myeloid cells constitute a heterogeneous cell population with greater Aβ-clearing capabilities. Here, we demonstrate that the conditional ablation of resident microglia in CD11b-HSVTK (TK) mice is followed by a rapid repopulation of the brain by peripherally derived myeloid cells. We used this system to directly assess the ability of peripheral macrophages to reduce Aβ pla

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Karpouzas, George Athanasios, Bianca Papotti, Sarah R. Ormseth, et al. "Changes in serum cholesterol loading capacity are linked to coronary atherosclerosis progression in rheumatoid arthritis." RMD Open 10, no. 4 (2024): e004991. https://doi.org/10.1136/rmdopen-2024-004991.

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ObjectiveExcess cholesterol loading on arterial macrophages is linked to foam cell formation, atherosclerosis and cardiovascular risk in rheumatoid arthritis (RA). However, the effect of changes in cholesterol loading on coronary plaque trajectory and the impact of RA therapies on this relationship are unknown. We investigated the association between variations in cholesterol loading capacity (CLC) over time and atherosclerosis progression.MethodsIn a prospective observational cohort study, coronary CT angiography evaluated atherosclerosis (non-calcified, partially calcified or fully calcified

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Drysdale, Amelia, Maria Blanco-Lopez, Stephen J. White, Amanda J. Unsworth, and Sarah Jones. "Differential Proteoglycan Expression in Atherosclerosis Alters Platelet Adhesion and Activation." International Journal of Molecular Sciences 25, no. 2 (2024): 950. http://dx.doi.org/10.3390/ijms25020950.

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Proteoglycans are differentially expressed in different atherosclerotic plaque phenotypes, with biglycan and decorin characteristic of ruptured plaques and versican and hyaluronan more prominent in eroded plaques. Following plaque disruption, the exposure of extracellular matrix (ECM) proteins triggers platelet adhesion and thrombus formation. In this study, the impact of differential plaque composition on platelet function and thrombus formation was investigated. Platelet adhesion, activation and thrombus formation under different shear stress conditions were assessed in response to individua

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Ferreira, Joana, Pedro Cunha, Alexandre Carneiro, et al. "Is Obesity a Risk Factor for Carotid Atherosclerotic Disease?—Opportunistic Review." Journal of Cardiovascular Development and Disease 9, no. 5 (2022): 162. http://dx.doi.org/10.3390/jcdd9050162.

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Obesity is a risk factor for coronary atherosclerosis. However, the influence of adipose tissue in carotid atherosclerosis is not completely understood. No systematic review/meta-analysis was previously performed to understand if obesity is a risk factor for carotid atherosclerosis. This paper aims to provide an opportunistic review of the association between obesity and carotid atherosclerosis and define the role of the different adipose tissue depots in the characteristics of carotid stenosis. The databases PubMed and Cochrane Library were searched on 15–27 April and 19 May 2021. A total of

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Roach, Dwayne R., David R. Sjaarda, Alan J. Castle, and Antonet M. Svircev. "Host Exopolysaccharide Quantity and Composition Impact Erwinia amylovora Bacteriophage Pathogenesis." Applied and Environmental Microbiology 79, no. 10 (2013): 3249–56. http://dx.doi.org/10.1128/aem.00067-13.

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ABSTRACTErwinia amylovorabacteriophages (phages) belonging to theMyoviridaeandPodoviridaefamilies demonstrated a preference for either high-exopolysaccharide-producing (HEP) or low-exopolysaccharide-producing (LEP) bacterial hosts when grown on artificial medium without or with sugar supplementation.Myoviridaephages produced clear plaques on LEP hosts and turbid plaques on HEP hosts. The reverse preference was demonstrated by mostPodoviridaephages, where clear plaques were seen on HEP hosts. Efficiency of plating (EOP) was determined by comparing phage growth on the original isolation host to

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Wang, Yaming, Tyler K. Ulland, Jason D. Ulrich, et al. "TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques." Journal of Experimental Medicine 213, no. 5 (2016): 667–75. http://dx.doi.org/10.1084/jem.20151948.

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Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor that recognizes changes in the lipid microenvironment, which may occur during amyloid β (Aβ) accumulation and neuronal degeneration in Alzheimer’s disease (AD). Rare TREM2 variants that affect TREM2 function lead to an increased risk of developing AD. In murine models of AD, TREM2 deficiency prevents microglial clustering around Aβ deposits. However, the origin of myeloid cells surrounding amyloid and the impact of TREM2 on Aβ accumulation are a matter of debate. Using parabiosis, we found that amyloid-associated

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Weathered, Catherine, Sophia Bardehle, Choya Yoon, et al. "Microglial Roles in Alzheimer's Disease: An Agent‐Based Model to Elucidate Microglial Spatiotemporal Response to Beta‐Amyloid." CPT: Pharmacometrics & Systems Pharmacology, December 11, 2023. http://dx.doi.org/10.1002/psp4.13095.

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AbstractAlzheimer's Disease (AD) is characterized by beta‐amyloid (Aβ) plaques in the brain and widespread neuronal damage. Due to high drug attrition rates in AD, there is increased interest in characterizing neuroimmune responses to Aβ plaques. In response to AD pathology, microglia are innate phagocytotic immune cells which transition into a neuroprotective state and form barriers around plaques. We seek to understand the role of microglia in modifying Aβ dynamics and barrier formation. To quantify the influence of individual microglia behaviors (activation, chemotaxis, phagocytosis, and pr

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Ricchiuto, Alfredo, Samuela Zella, Marco Lombardi, et al. "417 CLINICAL IMPACT OF HEALED CORONARY PLAQUES: AN OPTICAL COHERENCE TOMOGRAPHY STUDY." European Heart Journal Supplements 24, Supplement_K (2022). http://dx.doi.org/10.1093/eurheartjsupp/suac121.363.

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Abstract Introduction Pathological studies have shown that many atherosclerotic plaques destabilize without resulting in a clinical manifestation. Recent in vivo studies showed that healed plaques are more common in patients with chronic coronary syndrome (CCS) than in those with acute coronary syndrome (ACS), suggesting that they might be a marker of clinical stability. The aim of the present study was to evaluate the clinical impact of healed coronary plaques detected by optical coherence tomography (OCT) imaging. Methods A total of 208 patients with CCS or ACS who underwent OCT imaging of n

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Kojima, Keisuke, Yudai Tanaka, Saki Mizobuchi, et al. "Abstract 4141274: Impact of Oxidative Stress on Aortic Vulnerable Plaques Detected by Non-obstructive General Angioscopy." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4141274.

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Background: Atherosclerosis is the most common cause of cardiovascular death. Oxidative stress is related to the initiation and progression of atherosclerosis. However, how oxidative stress affects the progression of atherosclerosis in vivo has not yet been fully investigated. Non-obstructive general angioscopy (NOGA) can meticulously visualize directly aortic atherosclerosis in vivo. The purpose of this study was to evaluate the relationships between oxidative stress and NOGA-derived aortic plaques. Methods: We investigated 120 consecutive cases with coronary artery disease evaluated for the

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Koyama, Yutaka, Keisuke Kojima, Kurara Takahashi, et al. "Abstract 10040: Impact of Periaortic Adipose Tissue Detected by Computed Tomography on Aortic Vulnerable Plaques Identified by Non-Obstructive General Angioscopy." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.10040.

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Introduction: Periaortic adipose tissue (PAAT) is related to the development of cardiovascular disease. However, the relationship between periaortic adipose tissue (PAAT) and aortic plaque instability has not been elucidated. Hypothesis: We hypothesized that PAAT would be associated with aortic vulnerable plaques derived non-obstructive general angioscopy (NOGA) in patients with cardiovascular disease. Methods: We investigated 117 patients who underwent NOGA of the aorta and CT. PAAT volume was measured using the volume-rendering method by extracting the area from -30 to -190 HU within the tho

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Izumi, Chisato, Shuichi Takahashi, Sumiyo Hashiwada, et al. "Abstract 5772: The Impact of Aortic Plaque Morphology on Survival Rate and the Incidence of Subsequent Embolic Event: Very Long-Term Follow-Up Data." Circulation 118, suppl_18 (2008). http://dx.doi.org/10.1161/circ.118.suppl_18.s_999-b.

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Atheromatous plaques of the aorta have been regarded as a potential source of emboli, but there are few reports about the frequency and prognosis of patients with thoracic aortic plaques and about the relationship between plaque morphology and prognosis, especially long-term follow-up data. The purpose of this study is to clarify the impact of aortic atheromatous plaque morphology on survival rate and the incidence of subsequent embolic event. We retrospectively investigated 1570 consecutive patients who underwent transesophageal echocardiography between 1991 and 2003. The presence of severe p

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Tenekecioglu, E., R. Torii, Y. Katagiri, et al. "P5631The impact of plaque type on strut embedment/protrusion and shear stress distribution in bioresorbable scaffold." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz746.0575.

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Abstract Background and aim Scaffold design and plaque characteristics influence implantation outcomes and local flow dynamics in treated coronary segments. Our aim is to assess the impact of strut embedment/protrusion of bioresorbable scaffold on local shear stress distribution in different atherosclerotic plaque types. Method Fifteen Absorb everolimus-eluting Bioresorbable Vascular Scaffolds were implanted in human epicardial coronary arteries. Optical coherence tomography (OCT) was performed post-scaffold implantation and strut embedment/protrusion were analyzed using a dedicated software.

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Dahl, Jonathan Nørtoft, Marie B. Nielsen, Laust D. Rasmussen, et al. "Coronary Plaque Characteristics in Patients With Chronic Kidney Failure: Impact on Cardiovascular Events and Mortality." Circulation: Cardiovascular Imaging, September 30, 2024. http://dx.doi.org/10.1161/circimaging.124.017066.

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BACKGROUND: In patients with coronary artery disease, coronary plaques with high-risk features and low-attenuation plaque burden are independent measures associated with major adverse cardiovascular events (MACEs). Patients with chronic kidney failure may have different coronary artery disease characteristics. The aim was to assess the association of coronary plaque characteristics and coronary artery disease extent with MACE and all-cause mortality in patients with chronic kidney failure. METHODS: Potential kidney transplant candidates who underwent coronary computed tomography angiography as

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Broedl, Uli C., Corinna Lebherz, Michael Lehrke, et al. "Abstract 4223: Low Adiponectin Levels Are an Independent Predictor of Mixed and Non-Calcified Coronary Atherosclerotic Plaques." Circulation 118, suppl_18 (2008). http://dx.doi.org/10.1161/circ.118.suppl_18.s_847-b.

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We sought to examine the relationship of adiponectin with coronary atherosclerotic plaque morphology in patients with stable typical or atypical chest pain. There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels are associated with coronary artery disease and future incidence of acute coronary syndrome. The impact of adiponectin on lesion composition still remains to be determined. Serum adiponectin levels were determined in 303 patients with stable typical or atypical chest pain, who

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Rezvani Sharif, Alireza, Avinash Ashok, Anna Watson, et al. "Abstract 4139715: The impact of CSL112 and atorvastatin on lipid core stiffness in murine atherosclerotic plaques." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4139715.

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Background: Plaque structural stress (PSS) is the stress within the body of atherosclerotic plaques, resulting from the dilation and stretching of vessels due to arterial pressure. Plaque rupture often occurs at sites of elevated PSS, especially when the stress level exceeds the mechanical strength of the plaque. Notably, a significant difference in stiffness between the softer lipid core and the stiffer fibrous cap significantly increases PSS. By increasing the elastic modulus (a measure of material stiffness) of lipid cores and thus reducing the stiffness disparity between plaque components,

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Xi, Yan, Yi Xu, and Zheng Shu. "Impact of hypertension on coronary artery plaques and FFR-CT in type 2 diabetes mellitus patients: evaluation utilizing artificial intelligence processed coronary computed tomography angiography." Frontiers in Artificial Intelligence 7 (October 23, 2024). http://dx.doi.org/10.3389/frai.2024.1446640.

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ObjectiveThis study utilized artificial intelligence (AI) to quantify coronary computed tomography angiography (CCTA) images, aiming to compare plaque characteristics and CT-derived fractional flow reserve (FFR-CT) in type 2 diabetes mellitus (T2DM) patients with or without hypertension (HTN).MethodsA retrospective analysis was conducted on 1,151 patients with suspected coronary artery disease who underwent CCTA at a single center. Patients were grouped into T2DM (n = 133), HTN (n = 442), T2DM (HTN+) (n = 256), and control (n = 320). AI assessed various CCTA parameters, including plaque compon

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Fossdal, K., A. Joergensen, J. M. Letnes, R. Wiseth, and H. Dalen. "Prediction of the burden and characteristics of coronary plaques by cardiorespiratory fitness." European Heart Journal 45, Supplement_1 (2024). http://dx.doi.org/10.1093/eurheartj/ehae666.2766.

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Abstract Background Cardiorespiratory fitness (CRF) and coronary plaque burden are both important predictors of mortality. Although mortality of coronary heart disease (CHD) is reduced, prevalence remains high and there is a need to improve early detection and preventive measures. How CRF relates to coronary plaque burden and composition in the general population is largely unknown. Purpose The aim was to study the relationship between CRF and the total coronary plaque burden, including subgroups of coronary plaques, in subjects without known CHD. Methods A random sample of participants from a

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Görich, Hanna Maria, Sebastian J. Buss, Mostafa Emami, et al. "Short-Time Changes in Coronary Artery Plaques Assessed by Follow-Up Coronary CT Angiography—Characteristics and Impact on Patient Management." Frontiers in Cardiovascular Medicine 8 (August 9, 2021). http://dx.doi.org/10.3389/fcvm.2021.691665.

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Background: Coronary artery disease (CAD) shows a chronic but heterogeneous clinical course. Coronary CT angiography (CTA) allows for the visualization of the entire coronary tree and the detection of early stages of CAD. The aim of this study was to assess short-time changes in non-calcified and mixed plaques and their clinical impact using coronary CTA in a real-world setting.Methods: Between 11/2014 and 07/2019, 6,701 patients had a coronary CTA with a third-generation dual-source CT, of whom 77 patients (57 males, 63.8 ± 10.8 years) with a chronic CAD received clinically indicated follow-u

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Ahmed, Mona E., Diaa Hakim, and Peter H. Stone. "The plaque hypothesis: understanding mechanisms of plaque progression and destabilization, and implications for clinical management." Current Opinion in Cardiology, September 29, 2023. http://dx.doi.org/10.1097/hco.0000000000001077.

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Purpose of review Major adverse cardiac events (MACE) typically arise from nonflow-limiting coronary artery disease and not from flow-limiting obstructions that cause ischemia. This review elaborates the current understanding of the mechanism(s) for plaque development, progression, and destabilization and how identification of these high-risk features can optimally inform clinical management. Recent findings Advanced invasive and noninvasive coronary imaging and computational postprocessing enhance an understanding of pathobiologic/pathophysiologic features of coronary artery plaques prone to

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