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Journal articles on the topic 'Impaired glomerular filtration rate'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Fan, Letao, Wenjun Gao, Bond V. Nguyen, et al. "Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury." American Journal of Physiology-Renal Physiology 319, no. 4 (2020): F624—F635. http://dx.doi.org/10.1152/ajprenal.00239.2020.

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Recently, we reported a mutation in γ-adducin (ADD3) was associated with an impaired myogenic response of the afferent arteriole and hypertension-induced chronic kidney disease (CKD) in fawn hooded hypertensive (FHH) rats. However, the mechanisms by which altered renal blood flow (RBF) autoregulation promotes hypertension-induced renal injury remain to be determined. The present study compared the time course of changes in renal hemodynamics and the progression of CKD during the development of DOCA-salt hypertension in FHH 1BN congenic rats [wild-type (WT)] with an intact myogenic response ver

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2

Stahl, R. A., F. Thaiss, G. Oberle, et al. "The platelet activating factor receptor antagonist WEB 2170 improves glomerular hemodynamics and morphology in a proliferative model of mesangial cell injury." Journal of the American Society of Nephrology 2, no. 1 (1991): 37–44. http://dx.doi.org/10.1681/asn.v2137.

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Rats were treated with the platelet activating factor receptor antagonist WEB 2170 (15 mg/kg/day) in three different protocols to evaluate a possible role of platelet activating factor in an experimental proliferative model of glomerular disease. The glomerular immune injury was initiated by the i.v. administration of a rabbit anti-rat thymocyte antiserum. Anti-rat thymocyte antiserum induces a proliferative glomerulonephritis with reduction of glomerular filtration rate (614 +/- 94) compared with controls (1,120 +/- 192 microL/min/100 g body wt) when studied at day 7. Treatment of rats with W

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3

Vania Ilmi Basri, Husni та Desiekawati. "Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia". Bioscientia Medicina : Journal of Biomedicine and Translational Research 8, № 8 (2024): 4813–19. http://dx.doi.org/10.37275/bsm.v8i8.1057.

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Background: Patients with β-thalassemia major can experience impaired kidney function. Impaired kidney function can occur without symptoms and before serious manifestations appear, so early markers are needed to detect kidney damage. Estimated glomerular filtration rate (eGFR) is a calculation to detect early impairment of kidney function and is widely accepted as an indicator in determining overall kidney function. This study aims to determine the estimated glomerular filtration rate in pediatric patients with β-thalassemia major. Methods: This research is a descriptive research. Data was tak

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Filler, G., F. Priem, I. Vollmer, J. Gellermann, and K. Jung. "Diagnostic sensitivity of serum cystatin for impaired glomerular filtration rate." Pediatric Nephrology 13, no. 6 (1999): 501–5. http://dx.doi.org/10.1007/s004670050646.

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5

Laksmidewi, Anak Agung Ayu Putri, Cok Istri Gangga Dewi Dewi, and Yennny Kandarini. "Correlation Between Cognitive Function Impairment and Chronic Kidney Disease With a Low Glomerular Filtration Rate at Sanglah Hospital Denpasar." Open Access Macedonian Journal of Medical Sciences 8, B (2020): 752–56. http://dx.doi.org/10.3889/oamjms.2020.4691.

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BACKGROUND: Chronic kidney disease is a condition of chronic kidney damage with abnormal structure and function of the kidneys that lasts more than 3 months, accompanied or not by a decrease in glomerular filtration rate. Organic kidney disease leaves accumulated organic waste that cannot be removed by the kidneys. Furthermore, several biochemical and metabolic mechanisms such as chronic inflammation and oxidative stress can cause executive disorders. AIM: The aim of the study was to find out an increased risk of impaired cognitive function in patients with chronic kidney disease with a

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6

Laterza, Omar F., Christopher P. Price, and Mitchell G. Scott. "Cystatin C: An Improved Estimator of Glomerular Filtration Rate?" Clinical Chemistry 48, no. 5 (2002): 699–707. http://dx.doi.org/10.1093/clinchem/48.5.699.

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Abstract Background: Glomerular filtration rate (GFR) is routinely assessed by measuring the concentrations of endogenous serum markers such as blood urea nitrogen and serum creatinine (SCr). Although widely used, these endogenous markers are not ideal and do not perform optimally in certain clinical settings. The purpose of this review is to critically review the potential utility of cystatin C (CysC), especially in patient populations in which CysC may have an advantage over routinely used endogenous markers of GFR. Approach: In a narrative approach, we extensively review publications, prima

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Jančič, Sonja Golob, Mirjam Močnik, and Nataša Marčun Varda. "Glomerular Filtration Rate Assessment in Children." Children 9, no. 12 (2022): 1995. http://dx.doi.org/10.3390/children9121995.

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Glomerular filtration rate (GFR) measurement is a key tool for determining the degree of chronic kidney disease. The assessment of GFR is even more challenging in children than in adults with more variables in the equation than race and sex. Monitoring the progress of the kidney disease can therefore be difficult as in the initial stages of a decline in kidney function, there are no clinical signs. Due to children’s growth and development, changes in muscle mass and growth impair GFR estimation based solely on serum creatinine values. More invasive methods of GFR measurement are more reliable,

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8

Christensen, Per K., Eva E. Hommel, Peter Clausen, Bo Feldt-Rasmussen, and Hans Henrik Parving. "Impaired autoregulation of the glomerular filtration rate in patients with nondiabetic nephropathies." Kidney International 56, no. 4 (1999): 1517–23. http://dx.doi.org/10.1046/j.1523-1755.1999.00676.x.

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9

Guasch, A., H. Hashimoto, R. K. Sibley, W. M. Deen, and B. D. Myers. "Glomerular dysfunction in nephrotic humans with minimal changes or focal glomerulosclerosis." American Journal of Physiology-Renal Physiology 260, no. 5 (1991): F728—F737. http://dx.doi.org/10.1152/ajprenal.1991.260.5.f728.

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Fractional clearances (theta) of uncharged dextrans (radii 28-60 A) were used to characterize glomerular dysfunction in 34 nephrotic humans with either minimal-change nephropathy (MCN) or focal, segmental glomerulosclerosis (FSGS). A theoretical analysis of theta of dextran with a heteroporous membrane model revealed a similar alteration, more marked in FSGS than MCN. The number of restrictive pores perforating the major membrane component was reduced in parallel with the prevailing glomerular filtration rate (GFR). Parallel shuntlike pores in the remaining membrane component were more promine

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10

Kramer, Herbert J., Kriemhild Schwarting, and Angela Bäcker. "Impaired Renal Function in Obstructive Jaundice: Enhanced Glomerular Thromboxane Synthesis and Effects of Thromboxane Receptor Blockade in Bile Duct-Ligated Rats." Clinical Science 88, no. 1 (1995): 39–45. http://dx.doi.org/10.1042/cs0880039.

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1. Patients with obstructive jaundice are especially susceptible to acute renal failure. We have previously observed that in rats with bile duct ligation impaired renal function is associated with increased urinary thromboxane excretion. 2. In the present study we therefore investigated, in rats with bile duct ligation, renal function, urinary thromboxane excretion and thromboxane B2 synthesis by isolated glomeruli as well as the effects of the thromboxane A2/prostaglandin H2 receptor antagonist Daltroban on renal function in rats with bile duct ligation as compared with sham-operated rats. 3.

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Pyatchenkov, Mikhail O., Evgeniy V. Sherbakov, Alexandra E. Trandina, Aleksandra S. Buntovskaia, and Ruslan I. Glushakov. "Serum and fecal zonulin as a biomarker of increased intestinal epithelial permeability in patients with renal insufficiency." Russian Military Medical Academy Reports 42, no. 3 (2023): 237–46. http://dx.doi.org/10.17816/rmmar456495.

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BACKGROUND: Determination of zonulin level in body fluids is one of the widely used clinical methods for diagnosing the leaky gut syndrome. Meanwhile, a decrease in the glomerular filtration rate can potentially affect the content of zonulin in patients with impaired renal function. AIM: to evaluate the content of serum and fecal zonulin in subjects at different stages of chronic kidney disease. MATERIALS AND METHODS: The cross-sectional study included 3 groups of patients: 1) 155 patients with end-stage renal disease receiving hemodialysis treatment; 2) 30 patients with chronic ki

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Lavrishcheva, Y. V., A. A. Yakovenko, and A. N. Belskykh. "Criteria for assessing renal allograft dysfunction." Bulletin of the Russian Military Medical Academy 22, no. 2 (2020): 16–18. http://dx.doi.org/10.17816/brmma50038.

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The significance of the glomerular filtration rate calculated by the Cockcroft - Gault formula as one of the highly sensitive criteria for assessing renal allograft dysfunction is substantiated. The study demonstrated that in the group of patients with an increased level of daily proteinuria there is a significantly lower level of serum creatine in comparison with the group of patients with a normal level of daily proteinuria. Moreover, in patients with a normal level of daily proteinuria, there are significantly higher values of glomerular filtration rate calculated by the Cockcroft - Gault f

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13

Yoshioka, T., A. Yared, V. Kon, and I. Ichikawa. "Impaired preservation of GFR during hypotension in preexistent renal hypoperfusion." American Journal of Physiology-Renal Physiology 256, no. 2 (1989): F314—F320. http://dx.doi.org/10.1152/ajprenal.1989.256.2.f314.

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Autoregulation of renal blood flow and filtration rate was studied using micropuncture technique in Munich-Wistar rats with acute water deprivation (AWD) or congestive heart failure (CHF). In the first set of experiments, reduction of renal perfusion pressure to approximately to 70% of its initial value resulted in uncoupling of glomerular plasma flow rate and single-nephron glomerular filtration rate (GFR) (i.e., disproportionally profound fall in the latter) in AWD and CHF rats, whereas both indices changed little in normal control (NC) rats. The profound decrease in single-nephron GFR in AW

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14

Xue, Jun Lai, Meng Chao Zhang, Mao Hua Zhang, Dong Tong, and Wu Qiang. "Study of Multi-b-Value Diffusion-Weighted Imaging at 3.0 T for Measuring Renal Function of Patients with Chronic Renal Failure." Advanced Materials Research 998-999 (July 2014): 320–24. http://dx.doi.org/10.4028/www.scientific.net/amr.998-999.320.

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To investigate the relationship between apparent diffusion coefficient (ADC) values measured by diffusion-weighted imaging (DWI) on a 3.0T MR unit and glomerular filtration rate (GFR) determined by renal imaging using Nuclear Medicine 99 Tcm-DTPA. 3.0T MRI DWI and 99 Tcm-DTPA renal imaging were simultaneously performed in 30 patients with chronic renal failure. The b values set for DWI imaging were 0, 200, 400, 600, 800 and 1000 s/mm2 and the ADC values of renal cortex were measured. 60 kidneys from the patients were classified into three groups according to the measurements of GFR: mildly imp

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15

Rigalleau, V., C. Lasseur, C. Raffaitin, et al. "Prediction of glomerular filtration rate decline in diabetic subjects with impaired renal function." Nephrology Dialysis Transplantation 22, no. 3 (2007): 959–60. http://dx.doi.org/10.1093/ndt/gfl723.

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16

Moriya, Tatsumi, Shiro Tanaka, Hirohito Sone, et al. "Patients with type 2 diabetes having higher glomerular filtration rate showed rapid renal function decline followed by impaired glomerular filtration rate: Japan Diabetes Complications Study." Journal of Diabetes and its Complications 31, no. 2 (2017): 473–78. http://dx.doi.org/10.1016/j.jdiacomp.2016.06.020.

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17

López-Novoa, José M., and Inmaculada Montañés. "Effects of the enantiomers of a new dihydropyridine derivative, S12968 and S12967, on renal functions in rats." Canadian Journal of Physiology and Pharmacology 71, no. 10-11 (1993): 848–53. http://dx.doi.org/10.1139/y93-127.

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The aim of this study was to evaluate the effects of the two enantiomers of a new dihydropyridine, S12967 and S12968, on rat renal function. Male Wistar rats were injected intravenously with saline, S12967, or S12968 (0.1, 0.3, or 1 mg/kg body weight). Urinary flow, glomerular filtration rate, renal plasma flow, urinary sodium, potassium, and calcium excretions, mean arterial pressure, and renal vascular resistance were determined before and every 30 min up to 180 min after administration of the tested substance. The levogyre enantiomer S12968, at a dose of 0.3 mg/kg, induced a 4-fold increase

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18

Oshchepkova, E. V., Iu A. Dolgusheva, Iu V. Zhernakova, et al. "The prevalence of renal dysfunction in arterial hypertension (in the framework of the ESSE-RF study)." Systemic Hypertension 12, no. 3 (2015): 19–24. http://dx.doi.org/10.26442/sg29093.

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Objective. To study the prevalence of renal dysfunction, its relation with arterial hypertension and metabolic risk factors.Materials and methods. Data from the ESSE-RF study from 10 regions of the Russian Federation are presented. Renal dysfunction was assessed on the basis of the calculation of glomerular filtration rate (GFR). GFR calculation was conducted on the Chronic Kidney Disease Epidemiology Collaboration (GFR-EPI).Results. The study reveals a high prevalence of GFR decline in the population studied (76.8% in women and 23.2% in men). More unfavorable situation was found among the pat

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19

Lippi, Giuseppe, Gian Luca Salvagno, Martina Montagnana, Giovanni Targher, Massimo Franchini, and Gian Cesare Guidi. "No Correlation Between Lipoprotein(a) and Biochemical Markers of Renal Function in the General Population." Archives of Pathology & Laboratory Medicine 132, no. 9 (2008): 1436–38. http://dx.doi.org/10.5858/2008-132-1436-ncblab.

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Abstract Context.—Lipoprotein(a) (Lp(a)) is receiving major emphasis as an independent risk factor for cardiovascular disease. Results of studies on Lp(a) in patients with impaired renal function are contradictory, and no information is available on the association between Lp(a) and estimated glomerular filtration rate and cystatin C. Objective.—To evaluate the potential relationships among the biochemical markers creatinine, estimated glomerular filtration rate, and cystatin C and their association with Lp(a) in patients with impaired renal function. Design.—We performed a retrospective analy

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Meijers, Bjorn, and Jerome Lowenstein. "The Evolving View of Uremic Toxicity." Toxins 14, no. 4 (2022): 274. http://dx.doi.org/10.3390/toxins14040274.

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Indoxyl sulfate, closely related to indigo, a dye valued for it binding to cloth, has been recognized as a protein-bound solute bound to albumin, present in increased concentration in the serum of patients with impaired glomerular filtration (13). The early studies of Niwa identified indoxyl sulfate as a toxin capable of accelerating the rate of renal damage in subtotal nephrectomized rats (18). Over the past decade other protein-bound solutes have been identified in the plasma of patients with impaired glomerular filtration. Although the early studies, focused on the kidney, identified indoxy

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Serpa Neto, Ary, Felipe Martin Bianco Rossi, Rodrigo Dal Moro Amarante, and Marçal Rossi. "Predictive performance of 12 equations for estimating glomerular filtration rate in severely obese patients." Einstein (São Paulo) 9, no. 3 (2011): 294–301. http://dx.doi.org/10.1590/s1679-45082011ao1922.

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ABSTRACT Objective: Considering that the Cockcroft-Gault formula and the equation of diet modification in renal disease are amply used in clinical practice to estimate the glomerular filtration rate, although they seem to have low accuracy in obese patients, the present study intends to evaluate the predictive performance of 12 equations used to estimate the glomerular filtration rate in obese patients. Methods: This is a cross-sectional retrospective study, conducted between 2007 and 2008 and carried out at a university, of 140 patients with severe obesity (mean body mass index 44 ± 4.4 kg/m2

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Kurashina, Toshiaki, Kent A. Kirchner, Joey P. Granger, and Ami R. Patel. "Chronic Sodium-Potassium-ATPase Inhibition with Ouabain Impairs Renal Haemodynamics and Pressure Natriuresis in the Rat." Clinical Science 91, no. 4 (1996): 497–502. http://dx.doi.org/10.1042/cs0910497.

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1. Chronic Na+,K+-ATPase inhibition with ouabain induces hypertension in the rat. To examine the role of the kidney in this process, the effect of changes in renal perfusion pressure on glomerular filtration rate, renal blood flow and urinary sodium excretion were determined in rats treated intraperitoneally with ouabain (27.8 μg day−1 kg−1 body weight) or vehicle for 6 weeks. 2. After ouabain administration, baseline mean arterial pressure was significantly higher (P < 0.05) in ouabain-treated rats (151 ± 2 mmHg; n = 9) than in control rats (116 ± 4 mmHg; n = 8). 3. At equivalent renal per

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Nata, Naowanit, Ram Rangsin, Ouppatham Supasyndh, and Bancha Satirapoj. "Impaired Glomerular Filtration Rate in Type 2 Diabetes Mellitus Subjects: A Nationwide Cross-Sectional Study in Thailand." Journal of Diabetes Research 2020 (August 13, 2020): 1–9. http://dx.doi.org/10.1155/2020/6353949.

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Background. Type 2 diabetic mellitus (T2DM) patients with impaired renal function have a higher risk of mortality, and often progress to end-stage renal disease. The study aims to determine the prevalence of kidney disease and investigate the relationship between various factors and impaired renal function in a large population of patients with T2DM. Methods. We conducted a cross-sectional study among 30,377 patients from a nationwide diabetes study involving 602 Thai hospitals. Impaired glomerular filtration rate (GFR) was defined as <60 mL/min per 1.73 m2. Multivariate logistic regression

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Boisvert, Naomi C., Chet E. Holterman, Jean-François Thibodeau, et al. "Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice." Clinical Science 132, no. 13 (2018): 1453–70. http://dx.doi.org/10.1042/cs20180085.

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Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. Uchl1 deletion in mice leads to progressive axonal degeneration, affecting the dorsal root ganglion that harbors axons emanating to the kidney. Innervation is a crucial regulator of renal hemodynamics, though the contribution of neuronal UCHL1 to this is unclear. Immunofluorescence revealed significant neuronal UCHL1 expression in mouse kidney, including periglomerular axons. Glomerular filtration rate trended higher in 6-week-old Uchl1-/-

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Johansson, B. L., U. Berg, A. B. Bohlin, A. K. Lefvert, and U. Freyschuss. "Exercise-induced changes in renal function and their relation to plasma noradrenaline in insulin-dependent diabetic children and adolescents." Clinical Science 72, no. 5 (1987): 611–20. http://dx.doi.org/10.1042/cs0720611.

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1. Exercise-induced changes in renal haemodynamics, water homoeostasis, urinary albumin excretion and their possible relation to plasma noradrenaline were studied in seven insulin-dependent diabetic children and adolescents without signs of autonomic or somatic neuropathy. Six age-matched clinically healthy patients in remission from the minimal change nephrotic syndrome served as controls. 2. The diabetic patients had a higher glomerular filtration rate and effective renal plasma flow and a lower venous plasma noradrenaline level in the basal state. They also had a higher systolic blood press

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Lankadeva, Yugeesh R., Reetu R. Singh, Lucinda M. Hilliard, Karen M. Moritz, and Kate M. Denton. "Impaired ability to modulate glomerular filtration rate in aged female sheep following fetal uninephrectomy." Physiological Reports 2, no. 1 (2014): e00208. http://dx.doi.org/10.1002/phy2.208.

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Dinesch, Violeta, Mihail Dinesch, Cosmin Macarie, Ileana Voichita Sirbu, and Mircea Buruian. "Risk of Contrast-Induced Nephropathy after Repeated Contrast Medium Administration." Acta Medica Marisiensis 64, no. 3 (2018): 108–10. http://dx.doi.org/10.2478/amma-2018-0017.

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AbstractObjective: Non-invasive coronary computed tomography angiography is frequently used to exclude coronary artery disease in patients with low-to-intermediate pre-test probability because of the high negative predictive value. The strategy of coronary computed tomography angiography and subsequent invasive coronary angiography in case of positive findings has risks owing to repeated contrast medium administration and the possibility of contrast-induced nephropathy. Methods: We retrospectively evaluated the changes in the serum creatinine level and estimated glomerular filtration rate (at

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van de Velde, Mirjam E., Emil den Bakker, Hester N. Blufpand, et al. "Carboplatin Dosing in Children Using Estimated Glomerular Filtration Rate: Equation Matters." Cancers 13, no. 23 (2021): 5963. http://dx.doi.org/10.3390/cancers13235963.

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Renal function-based carboplatin dosing using measured glomerular filtration rate (GFR) results in more consistent drug exposure than anthropometric dosing. We aimed to validate the Newell dosing equation using estimated GFR (eGFR) and study which equation most accurately predicts carboplatin clearance in children with retinoblastoma. In 13 children with retinoblastoma 38 carboplatin clearance values were obtained from individual fits using MWPharm++. Carboplatin exposure (AUC) was calculated from administered dose and observed carboplatin clearance and compared to predicted AUC calculated wit

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Freundlich, Michael, Jacques J. Bourgoignie, Gaston Zilleruelo, Allan I. Jacob, Janet M. Canterbury, and Jose Strauss. "Bone Modulating Factors in Nephrotic Children with Normal Glomerular Filtration Rate." Pediatrics 76, no. 2 (1985): 280–85. http://dx.doi.org/10.1542/peds.76.2.280.

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Factors influencing bone and mineral metabolism were evaluated in 16 children with active nephrotic syndrome and normal glomerular filtration rate. All patients were proteinuric and/or hypoalbuminemic and had elevated serum triglyceride and cholesterol levels. Seven patients had never received or had discontinued glucocorticoid treatment at least 6 months before the study; six patients were receiving prednisone at the time of study. Although all patients were hypocalcemic (serum total or ionized calcium), none was hypomagnesemic. Despite the low serum calcium levels, circulating immunoreactive

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Vargas, Félix, Noemí M. Atucha, J. Mario Sabio, Tomás Quesada, and Joaquín García-Estañ. "Pressure-Diuresis-Natriuresis Response in Hyperthyroid and Hypothyroid Rats." Clinical Science 87, no. 3 (1994): 323–28. http://dx.doi.org/10.1042/cs0870323.

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1. Renal responses to changes in renal perfusion pressure were studied in anaesthetized hyperthyroid (thyroxine, 300 μg day−1 kg−1) and hypothyroid (methimazole, 0.03% via drinking water) rats to determine whether an abnormality in the pressure-diuresis-natriuresis phenomenon is involved in the resetting of kidney function in these disorders. 2. There were no significant differences between control and hypothyroid rats with respect to the relationships between renal perfusion pressure and absolute or fractional water and sodium excretion. However, in hyperthyroid rats the pressure-diuresis-nat

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Rosenthal, Raul J., David R. Funes, David G. Blanco, Emanuele Lo Menzo, and Samuel Szomstein. "Laparoscopic Sleeve Gastrectomy Improves Glomerular Filtration Rate in Morbidly Obese Patients with Impaired Kidney Function." Journal of the American College of Surgeons 225, no. 4 (2017): e3. http://dx.doi.org/10.1016/j.jamcollsurg.2017.07.529.

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German, Polina, Hui C. Liu, Javier Szwarcberg, et al. "Effect of Cobicistat on Glomerular Filtration Rate in Subjects With Normal and Impaired Renal Function." JAIDS Journal of Acquired Immune Deficiency Syndromes 61, no. 1 (2012): 32–40. http://dx.doi.org/10.1097/qai.0b013e3182645648.

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Risch, Lorenz, and Andreas R. Huber. "Assessing the diagnostic accuracy of cystatin C as a marker of impaired glomerular filtration rate." American Journal of Kidney Diseases 39, no. 3 (2002): 661. http://dx.doi.org/10.1053/ajkd.2002.32162.

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Eisen, Alon, Moshe Hoshen, Ran D. Balicer, et al. "Estimated Glomerular Filtration Rate Within the Normal or Mildly Impaired Range and Incident Cardiovascular Disease." American Journal of Medicine 128, no. 9 (2015): 1015–22. http://dx.doi.org/10.1016/j.amjmed.2015.03.024.

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Davidson, Michael B., John K. Hix, Donald G. Vidt, and Daniel J. Brotman. "Association of Impaired Diurnal Blood Pressure Variation With a Subsequent Decline in Glomerular Filtration Rate." Archives of Internal Medicine 166, no. 8 (2006): 846. http://dx.doi.org/10.1001/archinte.166.8.846.

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King, A. J., B. M. Brenner, and S. Anderson. "Endothelin: a potent renal and systemic vasoconstrictor peptide." American Journal of Physiology-Renal Physiology 256, no. 6 (1989): F1051—F1058. http://dx.doi.org/10.1152/ajprenal.1989.256.6.f1051.

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Endothelin is an endothelial cell-derived peptide recently shown to possess potent vasoconstrictor properties. Bolus intravenous injections of endothelin (5-450 pmol) into anesthetized Munich-Wistar rats induced a marked pressor effect, the magnitude and duration of which were dose dependent. Maximal systemic and renal responses occurred within 20 min and persisted for greater than 90 min in the higher dose range. In response to bolus dosages of 25 pmol or greater, renal plasma flow fell proportionately more than glomerular filtration rate, resulting in an increase in filtration fraction. In m

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Apurba Kumar Rabha, Swaroop Kumar Baruah, and Manjuri Sharma. "A hospital-based investigation into the relationship between serum uric acid levels and estimated glomerular filtration rate in patients with chronic kidney disease." World Journal of Biology Pharmacy and Health Sciences 22, no. 3 (2025): 519–23. https://doi.org/10.30574/wjbphs.2025.22.3.0630.

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Background: Chronic kidney disease (CKD) includes a range of pathophysiological processes linked to impaired kidney function and a gradual reduction in glomerular filtration rate. CKD has emerged as a global public health concern, associated with heightened risks of cardiovascular complications and decreased quality of life. Elevated serum uric acid levels are frequently observed in CKD, and this study aimed to investigate the relationship between serum uric acid levels and estimated glomerular filtration rate (eGFR) in patients with CKD. Methods: Uric acid and creatinine serum levels were ass

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Keevil, Brian G., Eric S. Kilpatrick, Simon P. Nichols, and Paul W. Maylor. "Biological variation of cystatin C: implications for the assessment of glomerular filtration rate." Clinical Chemistry 44, no. 7 (1998): 1535–39. http://dx.doi.org/10.1093/clinchem/44.7.1535.

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Abstract To assess the inherent potential for detecting mild to moderate reductions in glomerular filtration rate, this study determined the biological variability of serum cystatin C and creatinine in 12 healthy subjects. After accounting for analytical variation, interindividual variance accounted for 93% and intraindividual variance accounted for 7% of serum creatinine biological variation. As such, to lie outside the assay reference interval, some subjects must exceed 13 SD from their usual mean value, whereas in others, a change of only 2 SD would be sufficient. For cystatin C, interindiv

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Sällström, Johan, Christiane Peuckert, Xiang Gao, et al. "Impaired EphA4 signaling leads to congenital hydronephrosis, renal injury, and hypertension." American Journal of Physiology-Renal Physiology 305, no. 1 (2013): F71—F79. http://dx.doi.org/10.1152/ajprenal.00694.2012.

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Experimental hydronephrosis induced by partial ureteral obstruction at 3 wk of age causes hypertension and renal impairment in adult rats and mice. Signaling by Ephrin receptors (Eph) and their ligands (ephrins) importantly regulates embryonic development. Genetically modified mice, where the cytoplasmic domain of the EphA4 receptor has been substituted by enhanced green fluorescent protein ( EphA4 gf/gf), develop spontaneous hydronephrosis and provide a model for further studies of the disorder. The present study aimed to determine if animals with congenital hydronephrosis develop hypertensio

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Weidling, H., H. P. Breuel, H. J. Biersack, and M. J. Reinhardt. "Detection of impaired renal function." Nuklearmedizin 43, no. 06 (2004): 203–9. http://dx.doi.org/10.1055/s-0038-1623917.

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Summary Aim: Renal function is usually determined by means of creatinine-clearance, and of serum Cystatin C, the latter with increasing frequency. The present study analyses, whether the diagnostic accuracy of 99mTc-MAG3 clearance is comparable to that of these modern serologic methods. Patienten, Methods: 71 consecutive adult Caucasian patients (42 female, 29 male; age 50 ± 16 yrs., range 20 – 83) who were referred to a nuclear medicine department for determination of bilateral renal function with 99mTc-MAG3 were included. Following sufficient hydration, 10 ml of blood were taken for determin

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Franco, Martha, Rocío Bautista-Pérez, Agustina Cano-Martínez, et al. "Physiopathological implications of P2X1and P2X7receptors in regulation of glomerular hemodynamics in angiotensin II-induced hypertension." American Journal of Physiology-Renal Physiology 313, no. 1 (2017): F9—F19. http://dx.doi.org/10.1152/ajprenal.00663.2016.

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Deleterious effects of purinergic P2X1and P2X7receptors (P2XRs) in ANG II-dependent hypertension include increased renal vascular resistance, and impaired autoregulation and pressure natriuresis. However, their specific effects on the determinants of glomerular hemodynamics remain incompletely delineated. To investigate the P2XR contributions to altered glomerular hemodynamics in hypertension, the effects of acute blockade of P2X1R, P2X7R, and P2X4R with NF449, A438079, and PSB12054, respectively, were evaluated in ANG II-infused rats (435 ng·kg−1·min−1). P2X1R or P2X7R blockade reduced affere

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Klačar, Marija, Marija Zarić, and Jagoda Popović. "The relationship between body mass index and estimated glomerular filtration rate." Timocki medicinski glasnik 45, no. 4 (2020): 133–39. http://dx.doi.org/10.5937/tmg2004133k.

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INTRODUCTION: The increasing prevalence of chronic kidney disease (CKD) is a major health problem. The prevalence of obesity has also been rapidly increasing worldwide. Few studies have examined the relationship between excess body weight and CKD risk. Aim: To evaluate the possible contribution of increased body mass index (BMI) to impaired renal function in the general population sample. METHODS: The study involved 500 participants older than 30 years (228 men, 272 women, age 57.58±13.68) who visited their general practitioner in Health Center "Dr Simo Milošević". Blood samples, blood pressur

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Takayama, Tatsuya, Taro Kubo, Masahiro Yamazaki, et al. "Sunitinib versus sorafenib for patients with advanced renal cell carcinoma with renal impairment before the immune-oncology therapy era." Japanese Journal of Clinical Oncology 49, no. 12 (2019): 1164–71. http://dx.doi.org/10.1093/jjco/hyz127.

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Abstract Objectives The efficacy and safety of sunitinib versus sorafenib in patients with advanced renal cell carcinoma with renal impairment remains poorly documented. Patients and methods We assessed the efficacy and safety of sunitinib and sorafenib in patients with advanced renal cell carcinoma with an estimated glomerular filtration rate of 15–60 mL/min/1.73 m2 by reviewing the medical records of patients treated at Jichi Medical University Hospital, Japan, between May 2008 and August 2016. Results Twenty-seven patients were treated with sunitinib and 14 with sorafenib. Median progressio

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Brueckner, D., and M. M. Brueckner. "Renal impairment resulting from hypothyroidism--or impaired estimated glomerular filtration rate in a patient with hypothyroidsm." Clinical Kidney Journal 2, no. 3 (2009): 262–63. http://dx.doi.org/10.1093/ndtplus/sfp021.

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Joshi, SK, T. Murari, AS Narula, KV Baliga, and VD Charan. "How Robust are our Methods of Detecting Impaired Glomerular Filtration Rate in the Intensive Care Unit?" Medical Journal Armed Forces India 64, no. 2 (2008): 111–14. http://dx.doi.org/10.1016/s0377-1237(08)80049-4.

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Brueckner, D., and M. Brueckner. "Impaired estimated glomerular filtration rate associated with hypothyroidism. Does it really mean an acute renal failure?" Case Reports 2009, apr01 2 (2009): bcr0920080848. http://dx.doi.org/10.1136/bcr.09.2008.0848.

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Nazarova, V. V., O. N. Antropova, I. V. Osipova, A. N. Zhuravleva, and M. I. Semenova. "Masked uncontrolled hypertension in patients with impaired carbohydrate metabolism." Russian Journal of Cardiology 29, no. 5 (2024): 5862. http://dx.doi.org/10.15829/1560-4071-2024-5862.

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Aim. To establish the prevalence of masked uncontrolled hypertension (HTN) (MUH) in patients with diabetes or impaired glucose tolerance (IGT) and determine its clinical and hemodynamic characteristics.Material and methods. The study involved 87 patients who received regular antihypertensive therapy for hypertension and had established diabetes or IGT. The mean age of patients was 62,6±9,9 years, of which 51,7% were women, 48,3% — men. Type 2 diabetes was revealed in 77,7%, IGT — 22,8% of patients. For 24-hour blood pressure monitoring, BpLAB system (OOO Petr Telegin) was used; blood pressure

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Guler, Hans-Peter, Kai-U. Eckardt, Jürgen Zapf, Christian Bauer, and E. Rudolf Froesch. "Insulin-like growth factor I increases glomerular filtration rate and renal plasma flow in man." Acta Endocrinologica 121, no. 1 (1989): 101–6. http://dx.doi.org/10.1530/acta.0.1210101.

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Abstract. Recombinant IGF-I was infused sc at a dose of 20 μg · kg−1 · h−1 to 2 healthy subjects during a total of 79 h. Serum levels of IGF-I rose from 93 and 177 to 502 and 616 μg/l, respectively. Fasting blood glucose remained normal. During the infusion, glomerular filtration rate increased by 31% in subject No. 1 and by 32% in subject No.2. Concomitantly, renal plasma flow increased by 26% and 22%, respectively. Proximal and distal tubular reabsorption of fluid and sodium as determined by lithium clearance was elevated to a similar extent. When determined again one week after the end of t

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Westbrook, Adrianna, Ruiyuan Zhang, Mengyao Shi, et al. "Association Between Baseline Buccal Telomere Length and Progression of Kidney Function: The Health and Retirement Study." Journals of Gerontology: Series A 77, no. 3 (2022): 471–76. http://dx.doi.org/10.1093/gerona/glac004.

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Abstract We aimed to evaluate associations of baseline telomere length with overall and annual change in estimated glomerular filtration rate (eGFR) and trajectory of kidney function during an 8-year follow-up. A total of 3 964 participants of the Health and Retirement Study were included. We identified 3 trajectory groups of kidney function: consistently normal (n = 1 163 or 29.3%), normal to impaired (n = 2 306 or 58.2%), and consistently impaired groups (n = 495 or 12.5%). After controlling for age, sex, race, education, smoking, drinking, diabetes, heart disease, blood pressure, body mass

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Philip, Prijo, and Chinthu Sara Jacob. "Proximal renal tubular acidosis with primary Fanconi syndrome." International Journal of Contemporary Pediatrics 5, no. 3 (2018): 1131. http://dx.doi.org/10.18203/2349-3291.ijcp20181556.

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Renal tubular acidosis (RTA) is associated with normal or near normal glomerular filtration rate. Proximal RTA is associated with impaired bicarbonate reabsorption. This is manifested as bicarbonate wastage in the urine, and this reflects the defect in proximal tubular transport. Osteopenia or full-blown rickets may develop. Type 2 RTA is rare and occurs in association with conditions such as Fanconi syndrome. This is manifested as glycosuria, aminoaciduria, phosphate wasting and mild proteinuria. The basis of therapy is the continuous administration of appropriate amounts of alkali in the for

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