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Journal articles on the topic 'Impaired PTT'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Israelsson, Kjell-Erik, Renata Bogo, and Erik Berninger. "Reliability in Hearing Threshold Prediction in Normal-Hearing and Hearing-Impaired Participants Using Mixed Multiple ASSR." Journal of the American Academy of Audiology 26, no. 03 (2015): 299–310. http://dx.doi.org/10.3766/jaaa.26.3.9.

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Background and Purpose: The rapidly evolving field of hearing aid fitting in infants requires rapid, objective, and highly reliable methods for diagnosing hearing impairment. The aim was to determine test-retest reliability in hearing thresholds predicted by multiple auditory steady-state response (ASSRthr) among normal-hearing (NH) and hearing-impaired (HI) adults, and to study differences between ASSRthr and pure-tone threshold (PTT) as a function of frequency in each participant. ASSR amplitude versus stimulus level was analyzed to study ASSR growth rate in NH and HI participants, especiall

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Qian, Hai, Lucas Matt, Mingxu Zhang та ін. "β2-Adrenergic receptor supports prolonged theta tetanus-induced LTP". Journal of Neurophysiology 107, № 10 (2012): 2703–12. http://dx.doi.org/10.1152/jn.00374.2011.

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The widespread noradrenergic innervation in the brain promotes arousal and learning by molecular mechanisms that remain largely undefined. Recent work shows that the β2-adrenergic receptor (β2AR) is linked to the AMPA-type glutamate receptor subunit GluA1 via stargazin and PSD-95 (Joiner ML, Lise MF, Yuen EY, Kam AY, Zhang M, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW. EMBO J 29: 482–495, 2010). We now demonstrate that the β2AR plays a prominent role in long-term potentiation (LTP) induced by a train of 900 stimuli at 5 Hz (prol

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Sanjay, Nath Jha, Kumar Jha Rajesh, and Jha Vinayanand. "Clinical Study on Evaluation of Protein Tolerance Test as Marker for Early Renal Dysfunction in Type 2 Diabetes Mellitus." International Journal of Pharmaceutical and Clinical Research 15, no. 5 (2023): 847–52. https://doi.org/10.5281/zenodo.12582575.

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<strong>Background:</strong> A protein tolerance test can be highly helpful in selecting individuals who are most likely to benefit from an aggressive intervention by detecting incipient renal failure in those with normal GFR and serum creatinine values. This is crucial when assessing high-risk individuals including diabetics, people who have just undergone a kidney transplant, and people with polycystic kidney disease. PTT can be used to accurately predict the prognosis of a progressing renal disease and to evaluate the borderline renal donor. To demonstrate the value of the tubular stre

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Osokin, Roman, Ekaterina Komarova, Igor Aboyan, et al. "Intrarenal renin-angiotensin system in hypertensive patients with localized kidney cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e17069-e17069. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e17069.

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e17069 Background: In the last decade, the relationship between arterial hypertension and the risk of developing kidney cancer has been pointed out. Some studies have shown that the metabolic imbalance of the components of the renal renin-angiotensin system (RAS) is associated with the development and progression of kidney cancer. Aim: To study the state of RAS in tumor and peritumoral tissues in hypertensive patients with kidney cancer. Methods: In patients with localized kidney cancer T1N0M0 and grade I-II arterial hypertension without special treatment (n = 40; KC + AH) in the samples of tu

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Federici, Marco Orsini, Evangelia Mourvaki, Piero Ferolla, et al. "Impaired endothelial antithrombotic activity following short-term interruption of continuous subcutaneous insulin infusion in type1 diabetic patients." Thrombosis and Haemostasis 98, no. 09 (2007): 635–41. http://dx.doi.org/10.1160/th07-03-0201.

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SummaryReview of literature has shown an increased rate of thrombotic complications in diabetic patients with frequent episodes of hyperketonemia. However, the mechanisms by which ketosis promotes vascular disease in diabetic patients are unclear.It was the aim of this study to investigate early changes in haemostatic parameters and oxidative stress markers during the hyperketonemic status which follows the interruption of continuous subcutaneous insulin infusion (CSII) in type I diabetic patients. Eight CSII-treated type I diabetic patients underwent a 4-hour pump arrest. Blood glucose, insul

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Jabber, Halla A., Jaffar N. Alsaidissa, and Haithem A. Al-Rubaie. "The relationship between obesity and plasma level of factor V and fibrinogen." Journal of the Faculty of Medicine Baghdad 59, no. 1 (2017): 53–59. http://dx.doi.org/10.32007/jfacmedbagdad.591162.

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Background: Obesity is a medical condition in which excess body fat has accumulated to the extent that it has an adverse effect on health. . It measured by BMI (body mass index), obesity is considered when the BMI is ≥ 30 kg/m2. It increases the risk of coronary heart disease, Diabetes Mellitus and Cancer. Chronic inflammation and impaired fibrinolysis in obesity may induce thrombosis. Aim of study: assess the effect of BMI (body mass index) on plasma level of Factor V and fibrinogen in obese and normal weight subjects. Methods: This study was started on December 2015 and completed

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Zangari, Maurizio, Jose Guerrero, Federica Cavallo, et al. "Coagulation-Related Effect of Bortezomib Treatment in Patients with Relapsed or Refractory Multiple Myeloma." Blood 110, no. 11 (2007): 2733. http://dx.doi.org/10.1182/blood.v110.11.2733.2733.

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Abstract Proteasomes inhibitors have been recently identified as potential agents, which can influence processes leading to thrombosis. We have previously reported a reduced incidence of deep vein thrombosis (DVT) in 69 patients enrolled in Total Therapy III and treated with (B), dexamethasone, thalidomide, cisplatin and doxorubicin with prophylactic anticoagulation. Patients with relapse MM, not previously exposed to B with normal baseline coagulation parameters (PT, PTT fibrinogen and platelet count) were eligible for the study. Except for the two PCR-based genotyping assays Factor V Leiden

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Rezazadeh, Arash, Sandra C. Hollensead, Damian A. Laber, and Goetz H. Kloecker. "Intracranial Hemorrhage in a Patient with Osteogenesis Imperfecta Due to Inherited and Acquired Platelet Dysfunction." Blood 108, no. 11 (2006): 3960. http://dx.doi.org/10.1182/blood.v108.11.3960.3960.

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Abstract A 42 year-old man with Osteogenesis Imperfecta (OI) had three episodes of spontaneous Subdural Hematoma (SH) after binge drinking. There is no remote history of abnormal bleeding or easy bruising despite multiple fractures. Medications included Aspirin (ASA). The first and second SH occurred within the preceding year and were treated conservatively. The third SH occurred while on ASA and drinking more than 500cc liquor/day. The Platelet Function Assay (PFA-100) was significantly abnormal (see table). After platelet transfusions the SH was surgically evacuated without complications. An

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Holden, Maureen K., Kathleen M. Gill, and Marie R. Magliozzi. "Gait Assessment for Neurologically Impaired Patients." Physical Therapy 66, no. 10 (1986): 1530–39. http://dx.doi.org/10.1093/ptj/66.10.1530.

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Savvas, Steven M., and Stephen J. Gibson. "Treating pain in patients with impaired cognition." Pain Management 4, no. 5 (2014): 335–38. http://dx.doi.org/10.2217/pmt.14.27.

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Ballmann, Christopher G., Anna C. Covington, Rachel A. Miller, and Rebecca R. Rogers. "Protective Football Headgear and Peripheral Visuomotor Ability in NCAA Football Athletes: The Role of Facemasks and Visors." Journal of Functional Morphology and Kinesiology 6, no. 2 (2021): 34. http://dx.doi.org/10.3390/jfmk6020034.

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The purpose of this investigation was to determine the effects of varying facemask reinforcement and visor tint on peripheral visuomotor abilities in collegiate football players. Division I NCAA football players (n = 14) completed two peripheral visuomotor experiments: (1) Varying facemask reinforcement, (2) Varying visor tinting. In experiment 1, participants were tested under the following conditions: baseline (no helmet; BL), helmet + light (HL), helmet + medium (HM), helmet + heavy (HH), and helmet + extra heavy (HXH) reinforced facemasks. In experiment 2, participants were tested under th

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Siegel, Janet Collins, Maria Marchetti, and Jan Stephen Tecklin. "Age-Related Balance Changes in Hearing-Impaired Children." Physical Therapy 71, no. 3 (1991): 183–89. http://dx.doi.org/10.1093/ptj/71.3.183.

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13

Lobo, Michele A., Elena Kokkoni, Andrea Baraldi Cunha, and James Cole Galloway. "Infants Born Preterm Demonstrate Impaired Object Exploration Behaviors Throughout Infancy and Toddlerhood." Physical Therapy 95, no. 1 (2015): 51–64. http://dx.doi.org/10.2522/ptj.20130584.

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BackgroundObject exploration behaviors form the foundation for future global development, but little is known about how these behaviors are exhibited by infants born preterm.ObjectiveThe study objective was to longitudinally compare a comprehensive set of object exploration behaviors in infants born preterm and infants born full-term from infancy into toddlerhood.DesignTwenty-two infants born full-term and 28 infants born preterm were monitored as they interacted with objects throughout their first 2 years.MethodsInfants were provided up to 30 seconds to interact with each of 7 objects across

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Lin, Jiu-jenq, William P. Hanten, Sharon L. Olson, et al. "Shoulder Dysfunction Assessment: Self-report and Impaired Scapular Movements." Physical Therapy 86, no. 8 (2006): 1065–74. http://dx.doi.org/10.1093/ptj/86.8.1065.

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Abstract Background and Purpose. Shoulder dysfunction is common in various patient populations. This investigation was performed to assess shoulder dysfunction with self-report and performance-based functional measures. Subjects. Fifty men (25 with shoulder dysfunction and 25 without shoulder dysfunction) participated in this study. Methods. Self-report functional disabilities were assessed with the Flexilevel Scale of Shoulder Function (FLEX-SF), and electromagnetic tracking sensors were used to monitor 3-dimensional scapular movements during 4 functional tasks. Results. Relative to the contr

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Jack, Clifford R., Heather J. Wiste, Stephen D. Weigand, et al. "Predicting future rates of tau accumulation on PET." Brain 143, no. 10 (2020): 3136–50. http://dx.doi.org/10.1093/brain/awaa248.

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Abstract Clinical trials with anti-tau drugs will need to target individuals at risk of accumulating tau. Our objective was to identify variables available in a research setting that predict future rates of tau PET accumulation separately among individuals who were either cognitively unimpaired or cognitively impaired. All 337 participants had: a baseline study visit with MRI, amyloid PET, and tau PET exams, at least one follow-up tau PET exam; and met clinical criteria for membership in one of two clinical diagnostic groups: cognitively unimpaired (n = 203); or cognitively impaired (n = 134,

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Diab, Yaser A., Adia Thomas, Naomi L. C. Luban, et al. "Development of Impaired Cytochrome C Oxidase Activity In Apheresis Platelets During Storage." Blood 116, no. 21 (2010): 3347. http://dx.doi.org/10.1182/blood.v116.21.3347.3347.

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Abstract Abstract 3347 Background: With current storage requirements, the shelf life of platelet (PLT) products is largely limited by the development of deleterious in vitro changes associated with overall reduction in therapeutic efficacy collectively known as the “Platelet Storage Lesion” (PSL). PSL is characterized by a number of biochemical changes including lactate accumulation, bicarbonate depletion and a fall in pH. We hypothesize that these changes reflect a state of impaired oxidative phosphorylation associated with increased reliance on anaerobic glycolysis that evolves during PLT st

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ELSINGER, CATHERINE L., STEPHEN M. RAO, JANICE L. ZIMBELMAN, NORMAN C. REYNOLDS, KAREN A. BLINDAUER, and RAYMOND G. HOFFMANN. "Neural basis for impaired time reproduction in Parkinson's disease: An fMRI study." Journal of the International Neuropsychological Society 9, no. 7 (2003): 1088–98. http://dx.doi.org/10.1017/s1355617703970123.

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Studies involving brain-lesioned subjects have used the paced finger tapping (PFT) task to investigate the neural systems that govern motor timing. Patients with Parkinson's disease (PD), for example, demonstrate abnormal performance on the PFT, characterized by decreased accuracy and variability changes, suggesting that the basal ganglia may play a critical role in motor timing. Consistent with this hypothesis, an fMRI study of healthy participants demonstrated that the medial frontostriatal circuit (dorsal putamen, ventrolateral thalamus, SMA) correlated with explicit time-dependent componen

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Chen, B., F. Mahmud, J. Mangel, O. Vujovic, M. Rieder, and S. Zelcer. "Impaired endothelial function in Hodgkin lymphoma survivors receiving mediastinal radiation." Journal of Clinical Oncology 27, no. 15_suppl (2009): e19526-e19526. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e19526.

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e19526 Background: Mediastinal radiation (RT) is a cause of premature coronary artery disease (CAD) in Hodgkin lymphoma survivors (HLS). Early detection of atherosclerosis may allow for improved health outcomes. Peripheral arterial tonometry (PAT) is a non-invasive technique that measures endothelial function (EF), as a surrogate marker of sub-clinical atherosclerosis. The objective of our study was to evaluate EF in HLS and age-matched controls using PAT and to determine the association of mediastinal RT. Methods: Cross sectional evaluation of 26 HLS age 12–30 years and within a minimum of tw

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Van der Kraan, Y., D. Paap, H. Timmerman, et al. "POS0365 SEX DIFFERENCES CONCERNING EXPERIENCED PAIN IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 434.1–434. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4323.

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BackgroundResearch shows that there are significant sex differences in experienced pain. Contributing factors are neuroanatomical, hormonal, neuroimmunological, psychological, social, cultural, and comorbidities. Women have more and different expression of nociceptors, and a stronger proinflammatory response to tissue damage than men. Women also use different coping styles regarding to pain and tend to engage more in pain catastrophizing. Therefore, women may experiencing more severe pain than men. Also in axial spondyloarthritis (axSpA), higher pain scores are observed in women compared to me

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Kinjo, Nao, Hirofumi Kawanaka, Tomohiko Akahoshi, et al. "Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications." American Journal of Physiology-Gastrointestinal and Liver Physiology 295, no. 5 (2008): G1016—G1024. http://dx.doi.org/10.1152/ajpgi.90329.2008.

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Portal hypertensive (PHT) gastric mucosa increases susceptibility to injury and delayed mucosal healing. It is possible that nitration of ERK by peroxynitrite might alter MAPK (ERK) signaling in PHT gastric mucosa, leading to delayed mucosal healing, since excessive nitric oxide production is implicated in PHT gastric mucosa and MAPK (ERK) signaling induces cell proliferation and leads to gastric mucosal healing in response to injury. Portal hypertension was produced by staged portal vein ligation, and sham-operation (SO) rats served as controls. Lipid peroxide (LPO) and nitrotyrosine increase

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Inness, Elizabeth L., Avril Mansfield, Bimal Lakhani, Mark Bayley, and William E. McIlroy. "Impaired Reactive Stepping Among Patients Ready for Discharge From Inpatient Stroke Rehabilitation." Physical Therapy 94, no. 12 (2014): 1755–64. http://dx.doi.org/10.2522/ptj.20130603.

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Background Individuals with stroke are at increased risk for falls soon after hospital discharge. The ability to react to a balance perturbation, specifically with a rapid step, is critical to maintain balance and prevent falls. Objective The purpose of the study was to determine the prevalence of impaired reactive stepping responses in an ambulatory group of patients with stroke who were preparing for discharge from inpatient rehabilitation and the relationship to patient performance on commonly used clinical measures of balance, mobility, and lower limb impairment. Design This study was a re

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van Vliet, Paulette, and Alan M. Wing. "A New Challenge—Robotics in the Rehabilitation of the Neurologically Motor Impaired." Physical Therapy 71, no. 1 (1991): 39–47. http://dx.doi.org/10.1093/ptj/71.1.39.

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Forkan, Rebecca, Breeanna Pumper, Nicole Smyth, Hilary Wirkkala, Marcia A. Ciol, and Anne Shumway-Cook. "Exercise Adherence Following Physical Therapy Intervention in Older Adults With Impaired Balance." Physical Therapy 86, no. 3 (2006): 401–10. http://dx.doi.org/10.1093/ptj/86.3.401.

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Abstract Background and Purpose. This study looked at adherence, and factors affecting adherence, to a prescribed home exercise program (HEP) in older adults with impaired balance following discharge from physical therapy. Subjects. The subjects were 556 older adults (≥65 years of age) who were discharged from physical therapy during the period 2000 to 2003. Methods. A survey was developed to determine participation in a HEP. Univariate logistic regressions identified specific barriers and motivators that were associated with exercise participation following discharge from physical therapy. Re

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Brown, Jeremy S., Sarah M. Gilliland, Javier Ruiz-Albert, and David W. Holden. "Characterization of Pit, a Streptococcus pneumoniae Iron Uptake ABC Transporter." Infection and Immunity 70, no. 8 (2002): 4389–98. http://dx.doi.org/10.1128/iai.70.8.4389-4398.2002.

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ABSTRACT Bacteria frequently have multiple mechanisms for acquiring iron, an essential micronutrient, from the environment. We have identified a four-gene Streptococcus pneumoniae operon, named pit, encoding proteins with similarity to components of a putative Brachyspira hyodysenteriae iron uptake ABC transporter, Bit. An S. pneumoniae strain containing a defined mutation in pit has impaired growth in medium containing the iron chelator ethylenediamine di-o-hydroxyphenylacetic acid, reduced sensitivity to the iron-dependent antibiotic streptonigrin, and impaired virulence in a mouse model of

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Archer, Kristin R., Renan C. Castillo, Ellen J. MacKenzie, and Michael J. Bosse. "Gait Symmetry and Walking Speed Analysis Following Lower-Extremity Trauma." Physical Therapy 86, no. 12 (2006): 1630–40. http://dx.doi.org/10.2522/ptj.20060035.

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Abstract Background and PurposeGait has been shown to be a major determining factor of function following limb-salvage surgery. However, little is known regarding the measures associated with gait recovery for this patient population. The purpose of this study was to identify clinical measures associated with impaired walking speed and gait asymmetry in patients with lower-extremity reconstruction. Subjects. Study subjects were 381 patients from the Lower Extremity Assessment Project (LEAP) who had undergone reconstruction following severe lower-extremity trauma. Methods. The LEAP study was a

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Singh, Harpreet, Dinkar Bhasin, Vinisha Gunasekaran, Ujjwal Subedi, and Bhagwant Rai Mittal. "Potential Role of 13N-NH3 Cardiac PET in Monitoring Treatment Response in Patients with Microvascular Angina." Indian Journal of Nuclear Medicine 40, no. 2 (2025): 103–5. https://doi.org/10.4103/ijnm.ijnm_16_25.

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Ischemia with nonobstructive coronary artery disease (INOCA) refers to patients who present with signs and symptoms of myocardial ischemia despite the absence of obstructive coronary artery disease. Coronary microvascular dysfunction (CMD) is one of the underlying causes of INOCA and is associated with an increased risk of major adverse cardiac events. CMD is often detected as impaired coronary flow reserve (CFR) during invasive coronary angiography. We hereby report a patient with microvascular angina (MVA), having impaired myocardial flow reserve and perfusion defects at cardiac positron emi

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Prieto, Iván, Cristina Armas, and Francisco I. Pugnaire. "Hydraulic lift promotes selective root foraging in nutrient-rich soil patches." Functional Plant Biology 39, no. 9 (2012): 804. http://dx.doi.org/10.1071/fp12070.

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Hydraulic lift (HL) – the passive movement of water through plant roots from deep wet to shallow drier soil layers – can improve root survival in dry soils by providing a source of moisture to shallow roots. It may also enhance plant nutrient capture, though empirical evidence for this is scarce and whether HL promotes the selective placement of roots in nutrient-rich soil enhancing nutrient capture in dry soils remains unknown. We tested this with a split-pot design in which we separated the root system of Retama sphaerocarpa (L.) Boiss shrubs into two pot compartments: a lower, well-watered

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Mongillo, Paolo, Joseph A. Araujo, Elisa Pitteri, et al. "Spatial reversal learning is impaired by age in pet dogs." AGE 35, no. 6 (2013): 2273–82. http://dx.doi.org/10.1007/s11357-013-9524-0.

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Roig, M., J. J. Eng, D. L. MacIntyre, J. D. Road, and W. D. Reid. "Postural Control Is Impaired in People with COPD: An Observational Study." Physiotherapy Canada 63, no. 4 (2011): 423–31. http://dx.doi.org/10.3138/ptc.2010-32.

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Bowman, Caitlin, and Elizabeth W. Covington. "Determination of the Optimal Procalcitonin Threshold for Infection in Patients With Impaired Renal Function at a Community Hospital." Journal of Pharmacy Technology 36, no. 4 (2020): 157–63. http://dx.doi.org/10.1177/8755122520924803.

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Background: Procalcitonin (PCT) is a biomarker that can help identify bacterial infections but can be difficult to interpret in the presence of renal dysfunction, which can elevate PCT even in the absence of infection. Objective: To determine the optimal PCT threshold to identify infection in patients with renal dysfunction and pneumonia or sepsis. Methods: A retrospective analysis was performed for inpatients with creatinine clearance of ≤60 mL/min and PCT level from 2018 to 2019. A pharmacist blinded to study outcomes classified patients as infected or noninfected based on predetermined crit

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Stanton, Tasha R., Hayley B. Leake, K. Jane Chalmers, and G. Lorimer Moseley. "Evidence of Impaired Proprioception in Chronic, Idiopathic Neck Pain: Systematic Review and Meta-Analysis." Physical Therapy 96, no. 6 (2016): 876–87. http://dx.doi.org/10.2522/ptj.20150241.

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Background Despite common use of proprioceptive retraining interventions in people with chronic, idiopathic neck pain, evidence that proprioceptive dysfunction exists in this population is lacking. Determining whether proprioceptive dysfunction exists in people with chronic neck pain has clear implications for treatment prescription. Purpose The aim of this study was to synthesize and critically appraise all evidence evaluating proprioceptive dysfunction in people with chronic, idiopathic neck pain by completing a systematic review and meta-analysis. Data Sources MEDLINE, CINAHL, PubMed, Allie

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Liao, Fang-Yin, Chien-Lin Lin, Sui-Foon Lo, Chun-Ching Chang, Wen-Yen Liao, and Li-Wei Chou. "Efficacy of Acupoints Dual-Frequency Low-Level Laser Therapy on Knee Osteoarthritis." Evidence-Based Complementary and Alternative Medicine 2020 (September 24, 2020): 1–7. http://dx.doi.org/10.1155/2020/6979105.

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Background. Knee osteoarthritis (OA) presented with knee pain and limitation of mobility is common, and it may become a chronic problem resulting in major loss of function, with related impaired activity of daily living. Current traditional therapy for knee OA includes pharmacological treatment and physiotherapy, but the efficacies are limited. An alternative noninvasive treatment low-level laser therapy (LLLT) applied to acupoints is still contradictory and the efficacy needs to be assessed. Methods and Materials. We conduct the randomized double-blind control study to investigate the efficac

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Boyd, Lara A., Eric D. Vidoni, and Catherine F. Siengsukon. "Multidimensional Motor Sequence Learning Is Impaired in Older But Not Younger or Middle-Aged Adults." Physical Therapy 88, no. 3 (2008): 351–62. http://dx.doi.org/10.2522/ptj.20070131.

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Background and Purpose The purpose of this study was to identify which characteristics of a multidimensional sequence containing motor, spatial, and temporal elements would be most salient for motor sequence learning and whether age might differentially affect this learning. Subjects Younger (n=11, mean age=26.0 years), middle-aged (n=13, mean age=50.7 years), and older (n=11, mean age=77.5 years) adults who were neurologically intact participated in the study. Methods Participants practiced a sequencing task with repeated motor, spatial, and temporal dimensions for 2 days; on a separate third

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Kushner, David S., and Christina Amidei. "Rehabilitation of motor dysfunction in primary brain tumor patients†." Neuro-Oncology Practice 2, no. 4 (2015): 185–91. http://dx.doi.org/10.1093/nop/npv019.

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Abstract In 2010 it was estimated that >688 000 Americans were living with a primary brain tumor (PBT) corresponding to a U.S. prevalence rate of approximately 221.8 per 100 000 people. Five-year survival is 96.1% in nonmalignant PBTs, 34% in malignant PBTs for all ages, and 71% in children [1985–2005]. Case fatality rates have decreased in the U.S. since the 1970's for nonmalignant PBTs and for medulloblastoma, oligodendroglioma, and astrocytoma. Statistics of increasing survival highlight the importance of rehabilitation interventions to improve function and quality of life in survivors.

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Adams, Rick A., Daniel Bush, Fanfan Zheng, et al. "Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia." Brain 143, no. 4 (2020): 1261–77. http://dx.doi.org/10.1093/brain/awaa035.

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Abstract Frontotemporal dysconnectivity is a key pathology in schizophrenia. The specific nature of this dysconnectivity is unknown, but animal models imply dysfunctional theta phase coupling between hippocampus and medial prefrontal cortex (mPFC). We tested this hypothesis by examining neural dynamics in 18 participants with a schizophrenia diagnosis, both medicated and unmedicated; and 26 age, sex and IQ matched control subjects. All participants completed two tasks known to elicit hippocampal-prefrontal theta coupling: a spatial memory task (during magnetoencephalography) and a memory integ

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Piech, A., P. E. Massart, C. Dessy, et al. "Decreased expression of myocardial eNOS and caveolin in dogs with hypertrophic cardiomyopathy." American Journal of Physiology-Heart and Circulatory Physiology 282, no. 1 (2002): H219—H231. http://dx.doi.org/10.1152/ajpheart.2002.282.1.h219.

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Because nitric oxide (NO) regulates cardiac and vessel contraction, we compared the expression and activity of the endothelial NO synthase (eNOS) and caveolin, which tonically inhibits eNOS in normal and hypertrophic cardiomyopathic hearts. NOS activity (l-[3H]citrulline formation), eNOS immunostaining, and caveolin abundance were measured in heart tissue of 23 mongrel dogs before and at 3 and 7 wk of perinephritic hypertension (PHT). Hemodynamic parameters in vivo and endothelial NO-dependent relaxation of macro- and coronary microvessels in vitro were assessed in the same animals. eNOS immun

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Cade, W. Todd. "Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting." Physical Therapy 88, no. 11 (2008): 1322–35. http://dx.doi.org/10.2522/ptj.20080008.

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Physical therapists commonly treat people with diabetes for a wide variety of diabetes-associated impairments, including those from diabetes-related vascular disease. Diabetes is associated with both microvascular and macrovascular diseases affecting several organs, including muscle, skin, heart, brain, and kidneys. A common etiology links the different types of diabetes-associated vascular disease. Common risk factors for vascular disease in people with diabetes, specifically type 2 diabetes, include hyperglycemia, insulin resistance, dyslipidemia, hypertension, tobacco use, and obesity. Mech

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Suteerawattananon, Monthaporn, Betty MacNeill, and Elizabeth J. Protas. "Supported Treadmill Training for Gait and Balance in a Patient With Progressive Supranuclear Palsy." Physical Therapy 82, no. 5 (2002): 485–95. http://dx.doi.org/10.1093/ptj/82.5.485.

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Abstract Background and Purpose. Impaired balance, gait disturbances, and frequent falls are common problems in people with progressive supranuclear palsy (PSP). This case report describes the use of a modified body weight support treadmill training program to reduce falls and improve the balance and gait of a patient with PSP. Case Description. The patient was a 62-year-old man diagnosed with PSP. His major problems were impaired balance and frequent, abrupt falls. Methods. Physical therapy included walk training, balance perturbation, and step training using body weight support with a treadm

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Mansori, Mohammad Hani, Yousof Moghadas Tabrizi, and Mohammad Karimizadeh Ardakani. "Effects of a Four-Week Vestibular Exercise Program on Postural Control, Risk of Falling, and Quality of Life in Visually-impaired Individuals." Physical Treatments - Specific Physical Therapy 10, no. 1 (2020): 23–32. http://dx.doi.org/10.32598/ptj.10.1.429.1.

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Purpose: Visually-impaired individuals encounter difficulties in balance control and quality of life, and experience more instability, compared to healthy people. Thus, the present study aimed to evaluate the effects of vestibular exercises training program on postural control, risk of falling, and quality of life in individuals with visual impairment. Methods: This was a quasi-experimental study with a pretest-posttest and a control group design. In total, 24 men with visual impairment were randomly divided into the control and experimental groups. The experimental group performed a 4-week ve

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Yoshida, Koji, Kuniaki Ogasawara, Hiroaki Saura, et al. "Post-carotid endarterectomy changes in cerebral glucose metabolism on 18F-fluorodeoxyglucose positron emission tomography associated with postoperative improvement or impairment in cognitive function." Journal of Neurosurgery 123, no. 6 (2015): 1546–54. http://dx.doi.org/10.3171/2014.12.jns142339.

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OBJECT Cognitive function is often improved or impaired after carotid endarterectomy (CEA) for patients with cerebral hemodynamic impairment. Cerebral glucose metabolism measured using positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) correlates with cognitive function in patients with neurodegenerative diseases. The present study aimed to determine whether postoperative changes in cerebral glucose metabolism are associated with cognitive changes after CEA. METHODS In patients who were scheduled to undergo CEA for ipsilateral internal carotid artery (ICA) stenosis (≥ 70% nar

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Göttler, Jens, Christine Preibisch, Isabelle Riederer, et al. "Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer’s disease." Journal of Cerebral Blood Flow & Metabolism 39, no. 7 (2018): 1314–25. http://dx.doi.org/10.1177/0271678x18759182.

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Functional connectivity of blood oxygenation level dependent signal fluctuations (BOLD-FC) is decreased in Alzheimer’s disease (AD), and suggested to reflect reduced coherence in neural population activity; however, as both neuronal and vascular-hemodynamic processes underlie BOLD signals, impaired perfusion might also contribute to reduced BOLD-FC; 42 AD patients and 27 controls underwent simultaneous PET/MR imaging. Resting-state functional MRI assessed BOLD co-activity to quantify BOLD-FC, pulsed arterial spin labeling (pASL) assessed cerebral blood flow (CBF) as proxy for vascular hemodyna

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Jani, Chinmay, Kushboo Jain, Arpita Joshi, D. V. Bala, Harshal Jadav, and Divyesh Jetpariya. "Assessment of pulmonary function of industrial workers in four different industries of Gujarat." International Journal Of Community Medicine And Public Health 6, no. 8 (2019): 3234. http://dx.doi.org/10.18203/2394-6040.ijcmph20193088.

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Background: Industrial workers working in various industries have exposure to different kind of pollutants. Exposure to various types of dust causes pneumoconiosis, a rising cause of impairment in factory workers. This study sought to analyze the effect of quantity and quality of dust variety and the duration of exposure on the pulmonary function test of the workers.Methods: Pulmonary function testing (PFT) was done using PC based spirometer in 4 different industries of Ahmedabad and Gandhinagar cities. The PFT values obtained were compared with normal values and the number of workers with imp

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Silverman, Daniel H. S., and Abass Alavi. "PET imaging in the assessment of normal and impaired cognitive function." Radiologic Clinics of North America 43, no. 1 (2005): 67–77. http://dx.doi.org/10.1016/j.rcl.2004.09.012.

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JAIN, H., A. DRIESMAN, S. ZARICH, et al. "24.05: Impaired contractile reserve in obese subjects: A rubidium pet study." Journal of Nuclear Cardiology 15, no. 4 (2008): S26. http://dx.doi.org/10.1016/j.nuclcard.2008.06.147.

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Marra, F., P. Failli, G. Laffi, A. Gloiti, and P. Gentilini. "Impaired cytosolic metabolism in platelets (PLT) from cirrhotics with defective aggregation." Journal of Hepatology 11 (January 1990): S44. http://dx.doi.org/10.1016/0168-8278(90)91510-4.

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Laureys, S., S. Goldman, C. Phillips, et al. "Impaired Effective Cortical Connectivity in Vegetative State: Preliminary Investigation Using PET." NeuroImage 9, no. 4 (1999): 377–82. http://dx.doi.org/10.1006/nimg.1998.0414.

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Segeroth, Martin, David Jean Winkel, Beat A. Kaufmann, et al. "Noninvasive Assessment of Cardiopulmonary Hemodynamics Using Cardiovascular Magnetic Resonance Pulmonary Transit Time." International Journal of Biomedical Imaging 2024, no. 1 (2024). http://dx.doi.org/10.1155/2024/5691909.

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Introduction: Pulmonary transit time (PTT) is the time it takes blood to pass from the right ventricle to the left ventricle via the pulmonary circulation, making it a potentially useful marker for heart failure. We assessed the association of PTT with diastolic dysfunction (DD) and mitral valve regurgitation (MVR).Methods: We evaluated routine stress perfusion cardiovascular magnetic resonance (CMR) scans in 83 patients including assessment of PTT with simultaneously available echocardiographic assessment. Relevant DD and MVR were defined as exceeding Grade I (impaired relaxation and mild reg

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Haaf, P., M. Segeroth, D. J. Winkel, et al. "Multi-modality non-invasive assessment of cardiopulmonary haemodynamics using cardiovascular magnetic resonance pulmonary transit time and echocardiography." European Heart Journal - Cardiovascular Imaging 26, Supplement_1 (2025). https://doi.org/10.1093/ehjci/jeae333.446.

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Abstract Introduction Pulmonary transit time (PTT) is the time it takes blood to pass from the right ventricle to the left ventricle via the pulmonary circulation, making it a potentially useful marker for heart failure. We assessed the association of PTT with diastolic dysfunction and mitral valve regurgitation. Methods We evaluated routine stress perfusion cardiovascular magnetic resonance (CMR) scans in 83 patients including assessment of PTT with simultaneously available echocardiographic assessment. Relevant diastolic dysfunction (DD) and mitral valve regurgitation (MVR) were defined as e

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Zhou, Zaigang, Ning Jiang, Jiashe Chen, et al. "Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy." Journal of Nanobiotechnology 19, no. 1 (2021). http://dx.doi.org/10.1186/s12951-021-01124-8.

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Abstract Background Mild-temperature photothermal therapy (mild-PTT) has emerged as a highly promising antitumor strategy by triggering immunogenic cell death (ICD) to elicit both innate and adaptive immune responses for tumor control. However, mild-PTT still leads to the risk of tumor recurrence or metastasis because it could hardly completely eradicate tumors due to its impaired immunological efficacy owing to the enhanced PD-L1 expression in tumor cells after treatment. Results In this study, we described a hydrogen peroxide (H2O2) responsive manganese dioxide mineralized albumin nanocompos

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Vandi, Stefano, Sara Rodolfi, Fabio Pizza, et al. "Cardiovascular autonomic dysfunction, altered sleep architecture, and muscle overactivity during nocturnal sleep in pediatric patients with narcolepsy type 1." Sleep 42, no. 12 (2019). http://dx.doi.org/10.1093/sleep/zsz169.

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Abstract Study Objectives Arterial blood pressure (ABP) decreases during sleep compared with wakefulness and this change is blunted in mouse models of and adult patients with narcolepsy type 1 (NT1). We tested whether: (1) pediatric patients with NT1 have similar cardiovascular autonomic abnormalities during nocturnal sleep; and (2) these abnormalities can be linked to hypocretin-1 cerebrospinal fluid concentration (CSF HCRT-1), sleep architecture, or muscle activity. Methods Laboratory polysomnographic studies were performed in 27 consecutive drug-naïve NT1 children or adolescents and in 19 m

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