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Journal articles on the topic 'Implantable microelectrode arrays'

Author: Grafiati

Published: 6 September 2023

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1

Wei, Wen Jing, Yi Lin Song, Wen Tao Shi, Chun Xiu Liu, Ting Jun Jiang, and Xin Xia Cai. "A Novel Microelectrode Array Probe Integrated with Electrophysiology Reference Electrode for Neural Recording." Key Engineering Materials 562-565 (July 2013): 67–73. http://dx.doi.org/10.4028/www.scientific.net/kem.562-565.67.

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Nowadays, the study of brain function is advanced by implantable microelectrode arrays for they can simultaneously record signals from different groups of neurons regarding complex neural processes. This article presents the fabrication, characterization and use in vivo neural recording of an implantable microelectrode array probe which integrated with electrophysiology reference electrode. The probe was implemented on Silicon-On-Insulator (SOI) wafer using Micro-Electro-Mechanical-Systems (MEMS) methods, so the recording-site configurations and high-density electrode placement could be precis

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2

Hetke, J. F., J. L. Lund, K. Najafi, K. D. Wise, and D. J. Anderson. "Silicon ribbon cables for chronically implantable microelectrode arrays." IEEE Transactions on Biomedical Engineering 41, no. 4 (1994): 314–21. http://dx.doi.org/10.1109/10.284959.

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3

Zarifi, Mohammad Hossein, Javad Frounchi, Mohammad Ali Tinati, and Jack W. Judy. "PLATINUM-BASED CONE MICROELECTRODES FOR IMPLANTABLE NEURAL RECORDING APPLICATIONS." Biomedical Engineering: Applications, Basis and Communications 22, no. 03 (2010): 249–54. http://dx.doi.org/10.4015/s1016237210001992.

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There have been significant advances in fabrication of high-density microelectrode arrays using silicon micromachining technology in neural signal recording systems. The interface between microelectrodes and chemical environment is of great interest to researchers, working on extracellular stimulation. This interface is quite complex and must be modeled carefully to match experimental results. Computer simulation is a method to increase the knowledge about these arrays and to this end the finite element method (FEM) provides a strong environment for investigation of relative changes of the ele

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4

Johnson, Matthew D., Robert K. Franklin, Matthew D. Gibson, Richard B. Brown, and Daryl R. Kipke. "Implantable microelectrode arrays for simultaneous electrophysiological and neurochemical recordings." Journal of Neuroscience Methods 174, no. 1 (2008): 62–70. http://dx.doi.org/10.1016/j.jneumeth.2008.06.036.

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5

Green, Rylie A., Juan S. Ordonez, Martin Schuettler, Laura A. Poole-Warren, Nigel H. Lovell, and Gregg J. Suaning. "Cytotoxicity of implantable microelectrode arrays produced by laser micromachining." Biomaterials 31, no. 5 (2010): 886–93. http://dx.doi.org/10.1016/j.biomaterials.2009.09.099.

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6

Seymour, John P., Nick B. Langhals, David J. Anderson, and Daryl R. Kipke. "Novel multi-sided, microelectrode arrays for implantable neural applications." Biomedical Microdevices 13, no. 3 (2011): 441–51. http://dx.doi.org/10.1007/s10544-011-9512-z.

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7

Ghane-Motlagh, Bahareh, and Mohamad Sawan. "High-Density Implantable Microelectrode Arrays for Brain-Machine Interface Applications." Advances in Science and Technology 96 (October 2014): 95–101. http://dx.doi.org/10.4028/www.scientific.net/ast.96.95.

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Microelectrode arrays (MEAs) act as an interface between electronic circuits and neural tissues of implantable devices. Biological response to chronic implantation of MEAs is an essential factor in determining a successful electrode design. Finding appropriate coating materials which are biocompatible and improve electrical properties of MEAs are among the main challenges. In this paper, we propose a novel, three-dimensional (3D), high-density, silicon-based MEAs for both neural recording and stimulation. Electrodes were fabricated using micromachining techniques. Geometrical features of these

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Ji, J., and K. D. Wise. "An implantable CMOS circuit interface for multiplexed microelectrode recording arrays." IEEE Journal of Solid-State Circuits 27, no. 3 (1992): 433–43. http://dx.doi.org/10.1109/4.121568.

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9

de Haro, C., R. Mas, G. Abadal, J. Muñoz, F. Perez-Murano, and C. Domı́nguez. "Electrochemical platinum coatings for improving performance of implantable microelectrode arrays." Biomaterials 23, no. 23 (2002): 4515–21. http://dx.doi.org/10.1016/s0142-9612(02)00195-3.

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10

Black, Bryan J., Aswini Kanneganti, Alexandra Joshi-Imre, et al. "Chronic recording and electrochemical performance of Utah microelectrode arrays implanted in rat motor cortex." Journal of Neurophysiology 120, no. 4 (2018): 2083–90. http://dx.doi.org/10.1152/jn.00181.2018.

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Multisite implantable electrode arrays serve as a tool to understand cortical network connectivity and plasticity. Furthermore, they enable electrical stimulation to drive plasticity, study motor/sensory mapping, or provide network input for controlling brain-computer interfaces. Neurobehavioral rodent models are prevalent in studies of motor cortex injury and recovery as well as restoration of auditory/visual cues due to their relatively low cost and ease of training. Therefore, it is important to understand the chronic performance of relevant electrode arrays in rodent models. In this report

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11

Du, Jiangang, Ingmar H. Riedel-Kruse, Janna C. Nawroth, Michael L. Roukes, Gilles Laurent, and Sotiris C. Masmanidis. "High-Resolution Three-Dimensional Extracellular Recording of Neuronal Activity With Microfabricated Electrode Arrays." Journal of Neurophysiology 101, no. 3 (2009): 1671–78. http://dx.doi.org/10.1152/jn.90992.2008.

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Microelectrode array recordings of neuronal activity present significant opportunities for studying the brain with single-cell and spike-time precision. However, challenges in device manufacturing constrain dense multisite recordings to two spatial dimensions, whereas access to the three-dimensional (3D) structure of many brain regions appears to remain a challenge. To overcome this limitation, we present two novel recording modalities of silicon-based devices aimed at establishing 3D functionality. First, we fabricated a dual-side electrode array by patterning recording sites on both the fron

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Schuettler, M., S. Stiess, B. V. King, and G. J. Suaning. "Fabrication of implantable microelectrode arrays by laser cutting of silicone rubber and platinum foil." Journal of Neural Engineering 2, no. 1 (2005): S121—S128. http://dx.doi.org/10.1088/1741-2560/2/1/013.

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13

Negi, S., R. Bhandari, L. Rieth, and F. Solzbacher. "In vitro comparison of sputtered iridium oxide and platinum-coated neural implantable microelectrode arrays." Biomedical Materials 5, no. 1 (2010): 015007. http://dx.doi.org/10.1088/1748-6041/5/1/015007.

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14

Zeng, Qi, Saisai Zhao, Hangao Yang, Yi Zhang, and Tianzhun Wu. "Micro/Nano Technologies for High-Density Retinal Implant." Micromachines 10, no. 6 (2019): 419. http://dx.doi.org/10.3390/mi10060419.

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During the past decades, there have been leaps in the development of micro/nano retinal implant technologies, which is one of the emerging applications in neural interfaces to restore vision. However, higher feedthroughs within a limited space are needed for more complex electronic systems and precise neural modulations. Active implantable medical electronics are required to have good electrical and mechanical properties, such as being small, light, and biocompatible, and with low power consumption and minimal immunological reactions during long-term implantation. For this purpose, high-densit

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15

Jang, Jae-Won, Yoo Na Kang, Hee Won Seo, et al. "Long-term in-vivo recording performance of flexible penetrating microelectrode arrays." Journal of Neural Engineering 18, no. 6 (2021): 066018. http://dx.doi.org/10.1088/1741-2552/ac3656.

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Abstract Objective. Neural interfaces are an essential tool to enable the human body to directly communicate with machines such as computers or prosthetic robotic arms. Since invasive electrodes can be located closer to target neurons, they have advantages such as precision in stimulation and high signal-to-noise ratio (SNR) in recording, while they often exhibit unstable performance in long-term in-vivo implantation because of the tissue damage caused by the electrodes insertion. In the present study, we investigated the electrical functionality of flexible penetrating microelectrode arrays (

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Chakraborty, Bitan. "Electrochemical Properties of Sputtered Ruthenium Oxide Neural Stimulation and Recording Electrodes." Electrochem 4, no. 3 (2023): 350–64. http://dx.doi.org/10.3390/electrochem4030023.

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A chronically stable electrode material with a low impedance for recording neural activity, and a high charge-injection capacity for functional electro-stimulation is desirable for the fabrication of implantable microelectrode arrays that aim to restore impaired or lost neurological functions in humans. For this purpose, we have investigated the electrochemical properties of sputtered ruthenium oxide (RuOx) electrode coatings deposited on planar microelectrode arrays, using an inorganic model of interstitial fluid (model-ISF) at 37 °C as the electrolyte. Through a combination of cyclic voltamm

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Rui, Yuefeng, Jingquan Liu, Yajun Wang, and Chunsheng Yang. "Parylene-based implantable Pt-black coated flexible 3-D hemispherical microelectrode arrays for improved neural interfaces." Microsystem Technologies 17, no. 3 (2011): 437–42. http://dx.doi.org/10.1007/s00542-011-1279-x.

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18

Xiao, Guihua, Yilin Song, Yu Zhang, et al. "Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease." Biosensors 10, no. 10 (2020): 136. http://dx.doi.org/10.3390/bios10100136.

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(1) Background: Deep brain stimulation (DBS) is considered as an efficient treatment method for alleviating motor symptoms in Parkinson’s disease (PD), while different stimulation frequency effects on the specific neuron patterns at the cellular level remain unknown. (2) Methods: In this work, nanocomposites-modified implantable microelectrode arrays (MEAs) were fabricated to synchronously record changes of dopamine (DA) concentration and striatal neuron firing in the striatum during subthalamic nucleus DBS, and different responses of medium spiny projecting neurons (MSNs) and fast spiking int

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19

Saggese, Gerardo, and Antonio Giuseppe Maria Strollo. "A Low Power 1024-Channels Spike Detector Using Latch-Based RAM for Real-Time Brain Silicon Interfaces." Electronics 10, no. 24 (2021): 3068. http://dx.doi.org/10.3390/electronics10243068.

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High-density microelectrode arrays allow the neuroscientist to study a wider neurons population, however, this causes an increase of communication bandwidth. Given the limited resources available for an implantable silicon interface, an on-fly data reduction is mandatory to stay within the power/area constraints. This can be accomplished by implementing a spike detector aiming at sending only the useful information about spikes. We show that the novel non-linear energy operator called ASO in combination with a simple but robust noise estimate, achieves a good trade-off between performance and

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20

Amini, Shahram. "O021 / #592 HIERARCHICAL SURFACE RESTRUCTURING: A NOVEL TECHNOLOGY FOR NEXT GENERATION IMPLANTABLE NEURAL INTERFACING ELECTRODES AND MICROELECTRODE ARRAYS." Neuromodulation: Technology at the Neural Interface 25, no. 7 (2022): S50—S51. http://dx.doi.org/10.1016/j.neurom.2022.08.058.

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21

Yi, Wenwen, Chaoyang Chen, Zhaoying Feng, et al. "A flexible and implantable microelectrode arrays using high-temperature grown vertical carbon nanotubes and a biocompatible polymer substrate." Nanotechnology 26, no. 12 (2015): 125301. http://dx.doi.org/10.1088/0957-4484/26/12/125301.

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22

Jeakle, Eleanor N., Justin R. Abbott, Joshua O. Usoro, et al. "Chronic Stability of Local Field Potentials Using Amorphous Silicon Carbide Microelectrode Arrays Implanted in the Rat Motor Cortex." Micromachines 14, no. 3 (2023): 680. http://dx.doi.org/10.3390/mi14030680.

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Implantable microelectrode arrays (MEAs) enable the recording of electrical activity of cortical neurons, allowing the development of brain-machine interfaces. However, MEAs show reduced recording capabilities under chronic conditions, prompting the development of novel MEAs that can improve long-term performance. Conventional planar, silicon-based devices and ultra-thin amorphous silicon carbide (a-SiC) MEAs were implanted in the motor cortex of female Sprague–Dawley rats, and weekly anesthetized recordings were made for 16 weeks after implantation. The spectral density and bandpower between

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23

Lu, Botao, Penghui Fan, Yiding Wang, et al. "Neuronal Electrophysiological Activities Detection of Defense Behaviors Using an Implantable Microelectrode Array in the Dorsal Periaqueductal Gray." Biosensors 12, no. 4 (2022): 193. http://dx.doi.org/10.3390/bios12040193.

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Defense is the basic survival mechanism of animals when facing dangers. Previous studies have shown that the midbrain periaqueduct gray (PAG) was essential for the production of defense responses. However, the correlation between the endogenous neuronal activities of the dorsal PAG (dPAG) and different defense behaviors was still unclear. In this article, we designed and manufactured microelectrode arrays (MEAs) whose detection sites were arranged to match the shape and position of dPAG in rats, and modified it with platinum-black nanoparticles to improve the detection performance. Subsequentl

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24

Caldwell, Ryan, Himadri Mandal, Rohit Sharma, Florian Solzbacher, Prashant Tathireddy, and Loren Rieth. "Analysis of Al2O3—parylene C bilayer coatings and impact of microelectrode topography on long term stability of implantable neural arrays." Journal of Neural Engineering 14, no. 4 (2017): 046011. http://dx.doi.org/10.1088/1741-2552/aa69d3.

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25

Wu, Bingchen, Elisa Castagnola, and Xinyan Tracy Cui. "Zwitterionic Polymer Coated and Aptamer Functionalized Flexible Micro-Electrode Arrays for In Vivo Cocaine Sensing and Electrophysiology." Micromachines 14, no. 2 (2023): 323. http://dx.doi.org/10.3390/mi14020323.

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The number of people aged 12 years and older using illicit drugs reached 59.3 million in 2020, among which 5.2 million are cocaine users based on the national data. In order to fully understand cocaine addiction and develop effective therapies, a tool is needed to reliably measure real-time cocaine concentration and neural activity in different regions of the brain with high spatial and temporal resolution. Integrated biochemical sensing devices based upon flexible microelectrode arrays (MEA) have emerged as a powerful tool for such purposes; however, MEAs suffer from undesired biofouling and

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26

Narayana, V. Lakshman, and A. Peda Gopi. "Enterotoxigenic Escherichia Coli Detection Using the Design of a Biosensor." Journal of New Materials for Electrochemical Systems 23, no. 3 (2020): 164–66. http://dx.doi.org/10.14447/jnmes.v23i3.a02.

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The food industry and clinical analysis, among other sectors, require the development of techniques and devices that detect pathogens, while the development of implantable devices needs biocompatible materials with low degradation in biological environment to increase the lifetime of the device. Throughout this work, hydrogenated amorphous silicon-carbon alloy is proposed, obtained, characterized and incorporated into the development of a proposed interdigitated microelectrode array (PIMA) to capture the bacteria of enterotoxigenic Escherichia coli (E. coli, ETEC). a-SixC1-x:H is obtained by t

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Guan, S., J. Wang, X. Gu, et al. "Elastocapillary self-assembled neurotassels for stable neural activity recordings." Science Advances 5, no. 3 (2019): eaav2842. http://dx.doi.org/10.1126/sciadv.aav2842.

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Implantable neural probes that are mechanically compliant with brain tissue offer important opportunities for stable neural interfaces in both basic neuroscience and clinical applications. Here, we developed a Neurotassel consisting of an array of flexible and high–aspect ratio microelectrode filaments. A Neurotassel can spontaneously assemble into a thin and implantable fiber through elastocapillary interactions when withdrawn from a molten, tissue-dissolvable polymer. Chronically implanted Neurotassels elicited minimal neuronal cell loss in the brain and enabled stable activity recordings of

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28

Ferrea, E., L. Suriya-Arunroj, D. Hoehl, U. Thomas, and A. Gail. "Implantable computer-controlled adaptive multielectrode positioning system." Journal of Neurophysiology 119, no. 4 (2018): 1471–84. http://dx.doi.org/10.1152/jn.00504.2017.

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Acute neuronal recordings performed with metal microelectrodes in nonhuman primates allow investigating the neural substrate of complex cognitive behaviors. Yet the daily reinsertion and positioning of the electrodes prevents recording from many neurons simultaneously, limiting the suitability of these types of recordings for brain-computer interface applications or for large-scale population statistical methods on a trial-by-trial basis. In contrast, chronically implanted multielectrode arrays offer the opportunity to record from many neurons simultaneously, but immovable electrodes prevent o

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Sui, Xiao Hong, Fei Tan, and Qiu Shi Ren. "Electrical Characteristics of a Stimulating Microelectrode-Electrolyte Interface." Key Engineering Materials 483 (June 2011): 690–93. http://dx.doi.org/10.4028/www.scientific.net/kem.483.690.

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The electrochemical stability of the implantable microelectrode array is one of the most important considerations for effective neural stimulation. Electrical characteristics of a polyimide-based platinum microelectrode-electrolyte interface were presented in this paper, which could help determine some stimulus parameters in neural restoration applications. The novel 16-channel Φ-200 μm polyimide-based platinum thin-film flexible microelectrode array was micro-fabricated and an appropriate circuit model of the electrode-electrolyte interface was adopted with three different components of serie

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Li, Szu-Ying, Hsin-Yi Tseng, Bo-Wei Chen, et al. "Proof of Concept for Sustainable Manufacturing of Neural Electrode Array for In Vivo Recording." Biosensors 13, no. 2 (2023): 280. http://dx.doi.org/10.3390/bios13020280.

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Increasing requirements for neural implantation are helping to expand our understanding of nervous systems and generate new developmental approaches. It is thanks to advanced semiconductor technologies that we can achieve the high-density complementary metal-oxide-semiconductor electrode array for the improvement of the quantity and quality of neural recordings. Although the microfabricated neural implantable device holds much promise in the biosensing field, there are some significant technological challenges. The most advanced neural implantable device relies on complex semiconductor manufac

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31

Beygi, Mohammad, John T. Bentley, Christopher L. Frewin, et al. "Fabrication of a Monolithic Implantable Neural Interface from Cubic Silicon Carbide." Micromachines 10, no. 7 (2019): 430. http://dx.doi.org/10.3390/mi10070430.

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One of the main issues with micron-sized intracortical neural interfaces (INIs) is their long-term reliability, with one major factor stemming from the material failure caused by the heterogeneous integration of multiple materials used to realize the implant. Single crystalline cubic silicon carbide (3C-SiC) is a semiconductor material that has been long recognized for its mechanical robustness and chemical inertness. It has the benefit of demonstrated biocompatibility, which makes it a promising candidate for chronically-stable, implantable INIs. Here, we report on the fabrication and initial

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Swadlow, Harvey A., Yulia Bereshpolova, Tatiana Bezdudnaya, Monica Cano, and Carl R. Stoelzel. "A Multi-Channel, Implantable Microdrive System for Use With Sharp, Ultra-Fine “Reitboeck” Microelectrodes." Journal of Neurophysiology 93, no. 5 (2005): 2959–65. http://dx.doi.org/10.1152/jn.01141.2004.

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Arrays of closely spaced quartz-insulated, platinum-tungsten microelectrodes are widely used to obtain acute recordings from chronically prepared subjects. These electrodes have excellent recording characteristics and can be fabricated to a wide variety of tip specifications. Typically, in such experiments, electrodes are introduced into, and removed from, the brain on a daily basis and, over many months of study, hundreds of penetrations may be made through an intact dura. This procedure has benefits as well as problems and risks. For some experimental aims, it might be desirable to leave the

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Huang, Ting, Zhonghai Wang, Lina Wei, et al. "Microelectrode Array-evaluation of Neurotoxic Effects of Magnesium as an Implantable Biomaterial." Journal of Materials Science & Technology 32, no. 1 (2016): 89–96. http://dx.doi.org/10.1016/j.jmst.2015.08.009.

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34

Kim, Yong-Ho, Chungkeun Lee, Kang-Min Ahn, Myoungho Lee, and Yong-Jun Kim. "Robust and real-time monitoring of nerve regeneration using implantable flexible microelectrode array." Biosensors and Bioelectronics 24, no. 7 (2009): 1883–87. http://dx.doi.org/10.1016/j.bios.2008.09.034.

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35

Yoon, E., B. Koo, J. Wong, et al. "An implantable microelectrode array for chronic in vivo epiretinal stimulation of the rat retina." Journal of Micromechanics and Microengineering 30, no. 12 (2020): 124001. http://dx.doi.org/10.1088/1361-6439/abbb7d.

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36

Trada, Hiren V., Venkat Vendra, Joseph P. Tinney, et al. "Implantable thin-film porous microelectrode array (P-MEA) for electrical stimulation of engineered cardiac tissues." BioChip Journal 9, no. 2 (2015): 85–94. http://dx.doi.org/10.1007/s13206-015-9201-8.

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37

Guo, Rui, and Jing Liu. "Implantable liquid metal-based flexible neural microelectrode array and its application in recovering animal locomotion functions." Journal of Micromechanics and Microengineering 27, no. 10 (2017): 104002. http://dx.doi.org/10.1088/1361-6439/aa891c.

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38

Shan, Jin, Yilin Song, Yiding Wang, et al. "Highly Activated Neuronal Firings Monitored by Implantable Microelectrode Array in the Paraventricular Thalamus of Insomnia Rats." Sensors 23, no. 10 (2023): 4629. http://dx.doi.org/10.3390/s23104629.

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Insomnia is a common sleep disorder around the world, which is harmful to people’s health, daily life, and work. The paraventricular thalamus (PVT) plays an essential role in the sleep–wake transition. However, high temporal-spatial resolution microdevice technology is lacking for accurate detection and regulation of deep brain nuclei. The means for analyzing sleep–wake mechanisms and treating sleep disorders are limited. To detect the relationship between the PVT and insomnia, we designed and fabricated a special microelectrode array (MEA) to record electrophysiological signals of the PVT for

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Nazari, Hossein, Paulo Falabella, Lan Yue, James Weiland, and Mark S. Humayun. "Retinal Prostheses." Journal of VitreoRetinal Diseases 1, no. 3 (2017): 204–13. http://dx.doi.org/10.1177/2474126417702067.

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Artificial vision is restoring sight by electrical stimulation of the visual system at the level of retina, optic nerve, lateral geniculate body, or occipital cortex. The development of artificial vision began with occipital cortex prosthesis; however, retinal prosthesis has advanced faster in recent years. Currently, multiple efforts are focused on finding the optimal approach for restoring vision through an implantable retinal microelectrode array system. Retinal prostheses function by stimulating the inner retinal neurons that survive retinal degeneration. In these devices, the visual infor

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Broche, Lionel M., Karla D. Bustamante, and Michael Pycraft Hughes. "An Algorithm for Tracking the Position and Velocity of Multiple Neuronal Signals Using Implantable Microelectrodes In Vivo." Micromachines 12, no. 11 (2021): 1346. http://dx.doi.org/10.3390/mi12111346.

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Increasingly complex multi-electrode arrays for the study of neurons both in vitro and in vivo have been developed with the aim of tracking the conduction of neural action potentials across a complex interconnected network. This is usually performed through the use of electrodes to record from single or small groups of microelectrodes, and using only one electrode to monitor an action potential at any given time. More complex high-density electrode structures (with thousands of electrodes or more) capable of tracking action potential propagation have been developed but are not widely available

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Marland, Jamie, Mark Gray, David Argyle, Ian Underwood, Alan Murray, and Mark Potter. "Post-Operative Monitoring of Intestinal Tissue Oxygenation Using an Implantable Microfabricated Oxygen Sensor." Micromachines 12, no. 7 (2021): 810. http://dx.doi.org/10.3390/mi12070810.

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Anastomotic leakage (AL) is a common and dangerous post-operative complication following intestinal resection, causing substantial morbidity and mortality. Ischaemia in the tissue surrounding the anastomosis is a major risk-factor for AL development. Continuous tissue oxygenation monitoring during the post-operative recovery period would provide early and accurate early identification of AL risk. We describe the construction and testing of a miniature implantable electrochemical oxygen sensor that addresses this need. It consisted of an array of platinum microelectrodes, microfabricated on a s

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42

Atta, Raghied Mohammed. "Increasing contact area of microelectrodes in implantable microchannel array system for peripheral nerve regenerative using metal deposited nanospheres." International Journal of Nano and Biomaterials 2, no. 1/2/3/4/5 (2009): 313. http://dx.doi.org/10.1504/ijnbm.2009.027727.

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Zhang, Song, Yilin Song, Mixia Wang, et al. "A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain." Biosensors and Bioelectronics 85 (November 2016): 53–61. http://dx.doi.org/10.1016/j.bios.2016.04.087.

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44

Wei, Wenjing, Yilin Song, Xinyi Fan, et al. "Simultaneous recording of brain extracellular glucose, spike and local field potential in real time using an implantable microelectrode array with nano-materials." Nanotechnology 27, no. 11 (2016): 114001. http://dx.doi.org/10.1088/0957-4484/27/11/114001.

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45

Stutzki, Henrike, Florian Helmhold, Max Eickenscheidt, and Günther Zeck. "Subretinal electrical stimulation reveals intact network activity in the blind mouse retina." Journal of Neurophysiology 116, no. 4 (2016): 1684–93. http://dx.doi.org/10.1152/jn.01095.2015.

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Retinal degeneration ( rd) leads to progressive photoreceptor cell death, resulting in vision loss. Stimulation of the inner-retinal neurons by neuroprosthetic implants is one of the clinically approved vision-restoration strategies, providing basic visual percepts to blind patients. However, little is understood as to what degree the degenerating retinal circuitry and the resulting aberrant hyperactivity may prevent the stimulation of physiological electrical activity. Therefore, we electrically stimulated ex vivo retinas from wild-type ( wt; C57BL/6J) and blind ( rd10 and rd1) mice using an

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46

Kim, Kangil, Seung-Ju Han, Chang-Hee Kim, and Sangmin Lee. "Implantable nanostructured microelectrode array with biphasic current stimulator for retinal prostheses." Technology and Health Care, February 23, 2023, 1–15. http://dx.doi.org/10.3233/thc-235001.

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BACKGROUND: In retinal prosthetic systems on multi-channel microelectrodes to effectively stimulate retinal neurons, the electrode-electrolyte interface impedance of a microelectrode should be minimized to drive sufficiently large current at a given supply voltage. OBJECTIVE: This paper presents the fabrication of the nanostructured microelectrode array with simplified fabrication and its characteristic evaluation using biphasic current stimulator. METHODS: The nanostructured microelectrodes with the base diameter of 25 μm, 50 μm, 75 μm are fabricated, and the maximum allowable current injecti

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Corbett, Scott, Joe Ketterl, and Tim Johnson. "Polymer-Based Microelectrode Arrays." MRS Proceedings 926 (2006). http://dx.doi.org/10.1557/proc-0926-cc06-02.

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ABSTRACTWe have developed flexible, polymer-based electrodes for potential medical applications including neural recording and stimulation. Using various combinations of liquid crystal polymer (LCP) substrates, implantable grade silicone and polyimide, we have developed and tested several prototype multi-layer polymer electrodes. We report here on two specific electrodes. In the first case, a multilayer electrode consisting of high-melt temperature liquid crystal polymer (LCP) material with patterned electrodes of sputter deposited and plated gold, laminated together with a lower-melt temperat

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Lowe, Alexa, Safaa Hussain, Grace Xia, Ahsan Habib, and Ali Yanik. "Brain Computer Interfaces: Wireless Recording of Brain Signals with Electro-Plasmonic Nanoantenna." Journal of Student Research 11, no. 1 (2022). http://dx.doi.org/10.47611/jsrhs.v11i1.2421.

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Brain-computer interfaces (BCIs) recording brain signals via implantable sensors aims to substitute, restore, improve, add, or enhance human functions. However, wiring requirements for power transfer and signal transmission, acute immune response to implanted electrodes, and the limited scalability of the ever-popular microelectrode arrays prevent wide adaptation of BCIs. Here, we show that electro-plasmonic nanoparticles, plasmonic nanoparticles loaded with an electrochromic polymer, can overcome the limitations of the conventional implantable microelectrode arrays as BCI probes. Much like ra

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Hejazi, Maryam, Wei Tong, Michael R. Ibbotson, Steven Prawer, and David J. Garrett. "Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing." Frontiers in Neuroscience 15 (April 12, 2021). http://dx.doi.org/10.3389/fnins.2021.658703.

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Neural interfacing devices using penetrating microelectrode arrays have emerged as an important tool in both neuroscience research and medical applications. These implantable microelectrode arrays enable communication between man-made devices and the nervous system by detecting and/or evoking neuronal activities. Recent years have seen rapid development of electrodes fabricated using flexible, ultrathin carbon-based microfibers. Compared to electrodes fabricated using rigid materials and larger cross-sections, these microfiber electrodes have been shown to reduce foreign body responses after i

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Sun, Yimin, Xulin Dong, Hu He, et al. "2D carbon network arranged into high-order 3D nanotube arrays on a flexible microelectrode: integration into electrochemical microbiosensor devices for cancer detection." NPG Asia Materials 15, no. 1 (2023). http://dx.doi.org/10.1038/s41427-022-00458-5.

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AbstractIn this work, we develop a new type of mesoporous 2D N, B, and P codoped carbon network (NBP-CNW) arranged into high-order 3D nanotube arrays (NTAs), which are wrapped onto a flexible carbon fiber microelectrode, and this microelectrode is employed as a high-performance carbon-based nanocatalyst for electrochemical biosensing. The NBP-CNW-NTAs synthesized by a facile, controllable, ecofriendly and sustainable template strategy using ionic liquids as precursors possess a high structural stability, large surface area, abundant active sites, and effective charge transport pathways, which

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