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Relevant bibliographies by topics / Improved Systemic Bioavailability

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Academic literature on the topic 'Improved Systemic Bioavailability'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Improved Systemic Bioavailability"

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Tan, Sui Ling Janet, and Nashiru Billa. "Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles." Pharmaceutics 13, no. 11 (2021): 1817. http://dx.doi.org/10.3390/pharmaceutics13111817.

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Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve maximal bioavailability. Drug delivery systems made from nanoparticle carriers and especially, lipid carriers, have the potential to traverse gastrointestinal barriers and deploy in the lymphatic pathway, which aptly, is free from first pass via the liver. Several poorly soluble drugs have presented improved systemic bioavailability when couriered in lipid nanoparticle carriers.

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Hossain, Khondker Rufaka, Amani Alghalayini, and Stella M. Valenzuela. "Current Challenges and Opportunities for Improved Cannabidiol Solubility." International Journal of Molecular Sciences 24, no. 19 (2023): 14514. http://dx.doi.org/10.3390/ijms241914514.

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Cannabidiol (CBD), derived from the cannabis plant, has gained significant attention due to its potential therapeutic benefits. However, one of the challenges associated with CBD administration is its low bioavailability, which refers to the fraction of an administered dose that reaches systemic circulation. This limitation necessitates the exploration of various approaches to enhance the bioavailability of CBD, thus helping to maximize its therapeutic potential. A variety of approaches are now emerging, including nanoemulsion-based systems, lipid-based formulations, prodrugs, nanocarriers, an

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Het, Patel*, Patel Jaini, Ghanshyam Patel Dr., Yadav Priyanka, and Divykant Patel Dr. "REVIEW-SUBLINGUAL ROUTE FOR SYSTEMIC DRUG DELIVERY." World Journal of Pharmaceutical Science and Research 2, no. 2 (2023): 45–57. https://doi.org/10.5281/zenodo.10894235.

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Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Sublingual technology is convenient for dosing in ger

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Kim, Hyeongmin, Jong Hyuk Lee, Jee Eun Kim, et al. "Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability." Journal of Ginseng Research 42, no. 3 (2018): 361–69. http://dx.doi.org/10.1016/j.jgr.2017.12.003.

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Pawar, Poonam P., Hemant S. Ghorpade, and Bhavana A. Kokane. "Sublingual route for systemic drug delivery." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 340–43. http://dx.doi.org/10.22270/jddt.v8i6-s.2097.

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Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Sublingual technology is convenient for dosing in geriatric, pedi

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Rashid, Mamunur, Mohd Yaseen Malik, Sandeep K. Singh, Swati Chaturvedi, Jiaur R. Gayen, and Muhammad Wahajuddin. "Bioavailability Enhancement of Poorly Soluble Drugs: The Holy Grail in Pharma Industry." Current Pharmaceutical Design 25, no. 9 (2019): 987–1020. http://dx.doi.org/10.2174/1381612825666190130110653.

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Background: Bioavailability, one of the prime pharmacokinetic properties of a drug, is defined as the fraction of an administered dose of unchanged drug that reaches the systemic circulation and is used to describe the systemic availability of a drug. Bioavailability assessment is imperative in order to demonstrate whether the drug attains the desirable systemic exposure for effective therapy. In recent years, bioavailability has become the subject of importance in drug discovery and development studies. Methods: A systematic literature review in the field of bioavailability and the approaches

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Nilwani, Krutika S., Hemalata Wadkar, Aishwarya R. Ghanwat, and Shital P. Narwade. "A Review on In-Situ Nasal Gel." International Journal of Research and Review 12, no. 1 (2025): 603–11. https://doi.org/10.52403/ijrr.20250168.

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In situ gelling drug delivery techniques have garnered a lot of interest in the last ten years. When exposed to a range of endogenous stimuli, such as temperature increases, pH shifts, and the presence of ions, they can gel from their sol-state prior to injection. Systems can be given in a number of ways to facilitate the injection of a local or systemic treatment. They can also be used as efficient carriers for drug-carrying nanoparticles and microparticles. either natural, synthetic, or combined with a semi-artificial polymer that exhibits in situ gelling activity. In order to extend the tim

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Dubashynskaya, Natallia V., and Yury A. Skorik. "Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives." International Journal of Molecular Sciences 23, no. 21 (2022): 12980. http://dx.doi.org/10.3390/ijms232112980.

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Mucoadhesive polymer patches are a promising alternative for prolonged and controlled delivery of topical corticosteroids (CS) to improve their biopharmaceutical properties (mainly increasing local bioavailability and reducing systemic toxicity). The main biopharmaceutical advantages of patches compared to traditional oral dosage forms are their excellent bioadhesive properties and their increased drug residence time, modified and unidirectional drug release, improved local bioavailability and safety profile, additional pain receptor protection, and patient friendliness. This review describes

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Rachamalla, Hari Krishnareddy, Santanu Bhattacharya, Ajaz Ahmad, et al. "Enriched pharmacokinetic behavior and antitumor efficacy of thymoquinone by liposomal delivery." Nanomedicine 16, no. 8 (2021): 641–56. http://dx.doi.org/10.2217/nnm-2020-0470.

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Background: Thymoquinone (TQ) has potential anti-inflammatory, immunomodulatory and anticancer effects but its clinical use is limited by its low solubility, poor bioavailability and rapid clearance. Aim: To enhance systemic bioavailability and tumor-specific toxicity of TQ. Materials & methods: Cationic liposomal formulation of TQ (D1T) was prepared via ethanol injection method and their physicochemical properties, anticancer effects in orthotopic xenograft pancreatic tumor model and pharmacokinetic behavior of D1T relative to TQ were evaluated. Results: D1T showed prominent inhibition of

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Sharma, Ankit, Avinash Kumar Gupta, Manish Kumar Gupta, and Vijay Sharma. "A Review: Formulation and Characterization of Fast Dissolving Tablet of Carvidilol." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 749–52. http://dx.doi.org/10.22270/jddt.v9i3.2738.

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Carvedilol a poorly water soluble drug undergoes extensive first pass metabolism, which reduces its bioavailability to 25-30%. Fast dissolving tablets of Carvedilol were prepared with the purpose of delivering the drug directly into the systemic circulation and bypassing the hepatic first pass metabolism with a concomitant increase in bioavailability. The solubility of Carvedilol was improved by forming inclusion complex with cyclodextrin which was then further used for the formulation of Fast dissolving tablet. Keywords: Carvedilol, Superdisintegrats, Fast dissolving Tablets and FDTs.

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Book chapters on the topic "Improved Systemic Bioavailability"

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Garti, Nissim, Eli Pinthus, Abraham Aserin, and Aviram Spernath. "Improved Solubilization and Bioavailability of Nutraceuticals in Nanosized Self-Assembled Liquid Vehicles." In Encapsulation and Controlled Release Technologies in Food Systems. Blackwell Publishing, 2007. http://dx.doi.org/10.1002/9780470277881.ch2.

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Garti, Nissim, Eli Pinthus, Abraham Aserin, and Aviram Spernath. "Improved solubilization and bioavailability of nutraceuticals in nanosized self-assembled liquid vehicles." In Encapsulation and Controlled Release Technologies in Food Systems. John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118946893.ch7.

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Sailor, Girish U. "Self-Nanoemulsifying Drug Delivery Systems (SNEDDS): An Innovative Approach to Improve Oral Bioavailability." In Nanocarriers: Drug Delivery System. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4497-6_10.

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Kocaman, Suheyla. "Recent Trends in Smart Medicine and Nanotechnology for Diabetes: a Novel Strategy." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.14.

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Recent advancements in smart medicine and nanotechnology have introduced transformative approaches to managing diabetes mellitus, focusing on enhancing monitoring, diagnosis, and therapeutic interventions. Smart medicine leverages wearable devices, biosensors, and mobile health applications to enable continuous glucose monitoring (CGM) systems that provide real-time insights into glucose levels and metabolic trends. These systems not only improve patient compliance but also empower individuals with diabetes and their healthcare providers to make informed decisions regarding insulin dosing and

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Das, Dr Ratna Jyoti, Ms Purabi Das, Dr Kalyani Pathak, and Mrs Parimita Kalita. "NANO-DRUG DELIVERY SYSTEMS FOR THE ENHANCEMENT OF BIOAVAILABILITY AND BIOACTIVITY." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 3. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn3ch18.

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Bioavailability refers to the fraction of administered drug that reaches the systemic circulation in an unchanged form and is available to exert its therapeutic effects. It is the rate and extent to which a drug is absorbed from its dosage form and becomes available at the site of action. Bioavailability and bioactivity both the concepts are related to the effectiveness of drugs. The term pharmacological response is directly related to our body's blood plasma levels. Thus, bioavailability is defined as the rate and extent (amount) of absorption of an unchanged drug from its dosage form. An ide

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Maheshwari, Shubhrat, Ajeet Kumar, Shubham Sharma, Sayantan Dutta, Jagat Pal Yadav, and Sonia Pandey. "MUCOADHESIVE OCULAR NANOFORMULATIONS: ADVANCEMENTS IN DRUG DELIVERY FOR IMPROVED OCULAR THERAPY." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 9. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn9ch18.

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Ocular drug delivery poses a significant challenge due to the intricate structure and protective barriers present in the eye. Traditional techniques, including systemic administration and topical eye drops, often have limited therapeutic efficacy and poor bioavailability. However, the emergence of mucoadhesive ocular nanoparticles has the potential to revolutionize ocular drug delivery by overcoming these challenges. Eye drops remain a popular non-invasive method of treating ocular ailments. Nevertheless, conventional eye drop formulations are associated with several limitations, such as rapid

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Sabra, Rayan, and Nashiru Billa. "Gastrointestinal Delivery of APIs from Chitosan Nanoparticles." In Chitin and Chitosan - Physicochemical Properties and Industrial Applications [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.95363.

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Successful clinical treatment outcomes rely on achieving optimal systemic delivery of therapeutics. The oral route of administering Active Pharmaceutical Ingredients (API) remains formidable because of ease to the patient and convenience. Yet, the gastrointestinal tract (GIT) poses several barriers that need to be surmounted prior to systemic availability, especially for Class IV type drugs. Drug delivery systems in the form of nanoparticles (NP), can be appropriately formulated to alter the physicochemical properties of APIs, thereby addressing constraints related to absorption from the GIT.

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Jaiswal, Sandhya, Ghanshyam Das Gupta, Anjoo Kamboj, Kiran Yadav, and Nisha Yadav. "INTRODUCTION TO DOSAGE FORMS." In Futuristic Trends in Pharmacy & Nursing Volume 2 Book 24. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2023. http://dx.doi.org/10.58532/v2bs24ch12.

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Dosage form design is a multidiverse field which involves pathways from selection of drug and excipients to designing the formulation, manufacturing procedures, and quality assurance for the drug product. Prior to the development of any dosage form, it is important to understand the physical description of both the drug and excipients individually and in blend. Compatibility studies will results into stable dosage form throughout the shelf life. Thus before formulating a dosage form, a pharmacist should create the framework for product development by keeping in mind various factors like diseas

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Gidwani, Bina, Varsha Sahu, Priya Namdeo, et al. "Nanocarriers For Drug Targeting." In Nanoparticles and Nanocarriers-Based Pharmaceutical Formulations. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815049787122010006.

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Drug targeting specific cells/tissues of the body without their becoming a part of the systemic circulation is a prominent area of research in drug delivery, with the main emphasis on improvement in formulation and development. Drug-targeting can improve the viability, lower/minimize the adverse/side effects, and can become cost-effective. Certain limitations like short circulating half-life, bioavailability issues, rapid metabolism and degradation, poor tissue distribution and penetration in the blood-brain barrier, intestinal absorption barriers, etc., are associated with the delivery of var

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Ilhan, Miray, and Maide Ozturk. "Traditional Medicine and Modern Drug Delivery Systems: Promising Roles of PhytoNanotechnology in Rheumatoid Arthritis Treatment." In Herbal Medicine for Autoimmune Diseases. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815305005124010008.

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Phyto-nanotechnology presents a promising avenue for revolutionizing rheumatoid arthritis (RA) treatment. By integrating plant-derived compounds with nanotechnology, this approach addresses the limitations of conventional RA therapies. Nanoformulations of phytochemicals, such as curcumin, resveratrol, and quercetin, enable targeted drug delivery to inflamed joints, optimizing therapeutic efficacy while minimizing systemic side effects. Enhanced bioavailability, attributed to the encapsulation of phytochemicals within nanoparticles, facilitates improved pharmacokinetics and delivery across biol

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Conference papers on the topic "Improved Systemic Bioavailability"

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Ammari, WG, R. Tayyem, M. Abu Fara, and M. Sanders. "M35 Relative lung and systemic bioavailability and oropharyngeal deposition of salbutamol inhaled through pMDI alone and with an improved able spacer." In British Thoracic Society Winter Meeting 2018, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 5 to 7 December 2018, Programme and Abstracts. BMJ Publishing Group Ltd and British Thoracic Society, 2018. http://dx.doi.org/10.1136/thorax-2018-212555.455.

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Simion, Demetra, Carmen Gaidau, Mariana Daniela Berechet, Maria Stanca, and Rodica Roxana Constantinescu. "Modeling the Encapsulation of Turmeric in Nanoemulsions." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.i.9.

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The interaction of turmeric powder with five surfactants (isopropyl oleate, diester of sucrose, polymethylene-α, ω-bis (N, N-dialkyl-N-deoxy-d-glucitolammonium iodides, bis [2-butyl (sodium bis-thioacetate) sodium dicarboxylate 1,10 decanediyl] ester, demecarium bromide) and obtaining nanoemulsions, has been investigated by spectroscopy, dynamic light scattering, optical microscopy and microbiological tests. The modeling encapsulation of turmeric powder in nanoemulsions was carried out taking into account the following parameters: the concentration and type of surfactants, the ratio between tu

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Shafahi, Maryam, and Parham Piroozan. "Model of Drug Delivery to the Eye." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-39438.

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Ocular diseases cause vision deficiency and blindness in a substantial number of people in the world every day. Therefore, a controlled and sustained system of drug delivery to a specific spot within the eye is of interest for the ophthalmology community. The unique and complicated anatomy, physiology, and biochemistry of the eye make this organ highly resistant to drug delivery systems. The major challenge is to improve the efficiency of each treatment method along with avoiding the invasive techniques which damage the eye’s protective barrier tissues. In this work we make a computer model fo

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Rackov, Sanja, Aleksandra Nešić, Milan Vraneš, and Branka Pilić. "DEVELOPMENT OF ELECTROSPUN POLY(VINYLPYRROLIDONE) (PVP) NANOFIBER MATS LOADED BY CALENDULA OFFICINALIS EXTRACT AND COENZYME Q10." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.169r.

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Electrospun systems can be applied to various areas, particularly in biomedicine for skin treatment. The fabricated nanofibers represent an interconnected three-dimensional network with a high surface area to volume ratio providing structural and morphological similarities with the extracellular matrix. Hence, facilitate the removal of exudates, promote gaseous exchange, conform to the contour of the treated area and in the case of drug-loaded nanofibers resulting in improved bioavailability. Polyvinylpyrrolidone was selected as a polymer carrier due to its biocompatible, hydrophilic nature wi

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Neves, Marcos A., Isao Kobayashi, and Mitsutoshi Nakajima. "Scaling-Up Microchannel Emulsification Foreseeing Novel Bioactives Delivery Systems." In ASME 2013 11th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icnmm2013-73116.

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In the recent years, emulsification technologies that generate droplets individually have attracted a great deal attention in various fields, e.g., for chemicals, cosmetics, foods, and pharmaceuticals. Such drop-by-drop emulsification technologies include membrane emulsification using microporous membranes and microchannel (MC) emulsification, among others. The authors developed MC emulsification chips, consisting of parallel microgrooves or compactly arranged straight through-holes. Using this MC emulsification technique, the authors have evaluated the formulation a two-phase system consistin

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Reports on the topic "Improved Systemic Bioavailability"

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Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and

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