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Academic literature on the topic 'IMR'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 March 2023

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Journal articles on the topic "IMR"

1

Murai, Tadashi, Tetsumin Lee, Yoshihisa Kanaji, Junji Matsuda, Eisuke Usui, Makoto Araki, Takayuki Niida, et al. "The influence of elective percutaneous coronary intervention on microvascular resistance: a serial assessment using the index of microcirculatory resistance." American Journal of Physiology-Heart and Circulatory Physiology 311, no. 3 (September 1, 2016): H520—H531. http://dx.doi.org/10.1152/ajpheart.00837.2015.

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This study investigates whether hyperemic microvascular resistance (MR) is influenced by elective percutaneous coronary intervention (PCI) by using the index of microcirculatory resistance (IMR). Seventy-one consecutive patients with stable angina pectoris undergoing elective PCI were prospectively studied. The IMR was measured before and after PCI and at the 10-mo follow-up. The IMR significantly decreased until follow-up; the pre-PCI, post-PCI, and follow-up IMRs had a median of 19.8 (interquartile range, 14.6–28.9), 16.2 (11.8–22.1), and 14.8 (11.8–18.7), respectively ( P < 0.001). The pre-PCI IMR was significantly correlated with the change in IMR between pre- and post-PCI ( r = 0.84, P < 0.001) and between pre-PCI and follow-up ( r = 0.93, P < 0.001). Pre-PCI IMR values were significantly higher in territories with decreases in IMR than in those with increases in IMR [pre-PCI IMR: 25.4 (18.4–35.5) vs. 12.5 (9.4–16.8), P < 0.001]. At follow-up, IMR values in territories showing decreases in IMR were significantly lower than those with increases in IMR [IMR at follow-up: 13.9 (10.9–17.6) vs. 16.6 (14.0–21.4), P = 0.013]. The IMR decrease was significantly associated with a greater shortening of mean transit time, indicating increases in coronary flow ( P < 0.001). The optimal cut-off values of pre-PCI IMR to predict a decrease in IMR after PCI and at follow-up were 16.8 and 17.0, respectively. In conclusion, elective PCI affected hyperemic MR and its change was associated with pre-PCI MR, resulting in showing a wide distribution. Overall hyperemic MR significantly decreased until follow-up. The modified hyperemic MR introduced by PCI may affect post-PCI coronary flow.

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Jang, Ji-Hun, Man-Jong Lee, Kyu-Yong Ko, Jin-Hee Park, Yong-Soo Baek, Kwon Sung-Woo, Sung-Hee Shin, et al. "Mechanical and Pharmacological Revascularization Strategies for Prevention of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction: Analysis from Index of Microcirculatory Resistance Registry Data." Journal of Interventional Cardiology 2020 (July 9, 2020): 1–12. http://dx.doi.org/10.1155/2020/5036396.

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Objectives. We aimed to identify mechanical and pharmacological revascularization strategies correlated with the index of microcirculatory resistance (IMR) in ST-elevation myocardial infarction (STEMI) patients. Background. Microvascular dysfunction (MVD) after STEMI is correlated with infarct size and poor long-term prognosis, and the IMR is a useful analytical method for the quantitative assessment of MVD. However, therapeutic strategies that can reliably reduce MVD remain uncertain. Methods. Patients with STEMI who underwent primary percutaneous coronary intervention (PCI) were enrolled. The IMR was measured with a pressure sensor/thermistor-tipped guidewire immediately after primary PCI. High IMR was defined as values ≥66th percentile of IMR in enrolled patients (IMR > 30.9 IU). Results. A total of 160 STEMI patients were analyzed (high IMR = 54 patients). Clinical factors for Killip class P=0.006, delayed hospitalization from symptom onset P=0.004, peak troponin-I level P=0.042, and multivessel disease P=0.003 were associated with high IMR. Achieving final thrombolysis in myocardial infarction myocardial perfusion grade 3 tended to be associated with low IMR P=0.119, whereas the presence of distal embolization was significantly associated with high IMR P=0.034. In terms of therapeutic strategies that involved adjusting clinical and angiographic factors associated with IMR, preloading of third-generation P2Y12 inhibitors correlated with reducing IMR value (β = −10.30, P<0.001). Mechanical therapeutic strategies including stent diameter/length, preballoon dilatation, direct stenting, and thrombectomy were not associated with low IMR value (all P>0.05), and postballoon dilatation was associated with high IMR (β = 8.30, P=0.020). Conclusions. In our study, mechanical strategies were suboptimal in achieving myocardial salvage. Preloading of third-generation P2Y12 inhibitors revealed decreased IMR value, indicative of MVD prevention.

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Owens-Young, Jessica, and Caryn N. Bell. "Structural Racial Inequities in Socioeconomic Status, Urban-Rural Classification, and Infant Mortality in US Counties." Ethnicity & Disease 30, no. 3 (July 8, 2020): 389–98. http://dx.doi.org/10.18865/ed.30.3.389.

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Objectives: Despite improvements in infant mortality rates (IMR) in the United States, racial gaps in IMR remain and may be driven by both structural racism and place. This study assesses the relationship between structural racism and race-specific IMR and the role of urban-rural classification on race-specific IMR and Black/White racial gaps in IMR.Methods: We conducted an analysis of variance tests using 2019 County Health Rankings Data to determine differences in structural racism indicators, IMR and other co-variates by urban-rural classification. We used linear regressions to determine the associations between measures of structural racism and county-level health outcomes.Results: Study results suggest that racial inequities in education, work, and homeownership negatively impact Black IMR, especially in large fringe, medium, and small metro counties, and positively impact White IMR. Structural racism is also associated with Black-White gaps in IMR.Conclusions: Factors related to structural racism may not be homogenous or have the same impacts on overall IMR, race-specific IMR, and racial differences in IMR across places. Understanding these differential impacts can help public health professionals and policymakers improve Black infant health and eliminate racial inequities in IMR. Ethn Dis. 2020;30(3):389-398; doi:10.18865/ed.30.3.389

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Berry, Stephanie E. "Democracy and the Preservation of Minority Identity: Fragmentation within the European Human Rights Framework." International Journal on Minority and Group Rights 24, no. 3 (August 8, 2017): 205–28. http://dx.doi.org/10.1163/15718115-02403005.

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The international human rights (ihr) and international minority rights (imr) regimes have very different origins. However, the two regimes converged in the 20th century, and imr are now understood to be a sub-regime of ihr. This article argues that the different historical origins of the two regimes impact how actors within each regime interpret their mission, and have resulted in institutional fragmentation within the Council of Europe. The mission of the European Court of Human Rights is the promotion and protection of democracy, whereas the Advisory Committee to the Framework Convention for the Protection of National Minority’s mission is the preservation of minority identity. In practice, this has led to conflicting interpretations of multi-sourced equivalent norms. It is suggested that inter-institutional dialogue provides an avenue through which these conflicting interpretations can be mediated.

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5

Castillero, Estibaliz, Daniel P. Howsmon, Bruno V. Rego, Samuel J. Keeney, Kathryn H. Driesbaugh, Takayuki Kawashima, Yingfei Xue, et al. "Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 6 (June 2021): 2049–62. http://dx.doi.org/10.1161/atvbaha.121.316111.

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Objective: Ischemic mitral regurgitation (IMR) often develops after an ischemic event, which results in distortion of the valvulo-ventricular complex and incomplete mitral valve (MV) leaflet coaptation. After left ventricular ischemic events, only some patients develop IMR. The susceptibility of the MV to remodel may influence whether IMR develops. We hypothesized that impaired signaling response in MV cells may contribute to IMR development by inducing maladaptive tissue remodeling. Approach and Results: Sheep (n=14) were subjected to ligation of the circumflex coronary artery to induce myocardial infarction. IMR was reported by echocardiography. MV leaflets and MV interstitial cells (MVICs) were collected at baseline (control, n=10), 4 and 8 weeks post-myocardial infarction. RNA sequencing highlighted differences in TGFβ (transforming growth factor beta) signaling between MV with/without IMR. SMAD6/7 and ID2 (inhibitor of DNA binding 2) were the highest increased TGFβ-signaling genes associated with IMR. MVICs from myocardial infarction sheep were less responsive to BMP (bone morphogenic protein) 4 pro-osteogenic stimulation (ID2, OPN [osteopontin], and OC [osteocalcin] mRNA) than control. MVICs from IMR sheep had a diminished COL (collagen) 1A1 mRNA response to TGFβ1 and enhanced prochondrogenic RUNX2 (runt-related transcription factor 2) and SOX9 mRNA response to BMP4 versus non-IMR MVICs. Baseline CD45 (cluster of differentiation) expression was detectable only in IMR MVICs. Upon TGFβ1 stimulation, CD45 expression was detected in all groups. Immunostaining confirmed increased presence of CD45+ cells in IMR MV interstitium. Conclusions: MVs from sheep with IMR had an altered TGFβ/BMP response, associated with increased CD45+ cell presence within the tissue interstitium. Pharmacological strategies aimed to modulate TGFβ/BMP signaling after myocardial infarction may protect from pathological MV remodeling leading to IMR.

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Hickethier, Tilman, Bettina Baeßler, Jan Robert Kroeger, Dirk Müller, David Maintz, Guido Michels, and Alexander C. Bunck. "Knowledge-based iterative reconstructions for imaging of coronary artery stents: first in-vitro experience and comparison of different radiation dose levels and kernel settings." Acta Radiologica 60, no. 2 (May 28, 2018): 160–67. http://dx.doi.org/10.1177/0284185118778875.

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Background Advanced knowledge-based iterative model reconstructions (IMR) became recently available for routine computed tomography (CT). Using more realistic physical models it promises improved image quality and potential radiation dose reductions, both possibly beneficial for non-invasive assessment of coronary stents. Purpose To evaluate the influence of different IMR settings at different radiation doses on stent lumen visualization in comparison to filtered back projection (FBP) and first-generation (hybrid) iterative reconstruction (HIR). Material and Methods Ten coronary stents in a coronary phantom were examined at four different dose settings (120 kV/125 mAs, 120 kV/75 mAs, 100 kV/125 mAs, 100 kV/75 mAs). Images were reconstructed with stent-specific FBP and HIR kernels and with IMR using CardiacRoutine (CR) and CardiacSharp (CS) settings at three different iteration levels. Image quality was evaluated using established parameters: image noise; in-stent attenuation difference; and visible lumen diameter. Results Image noise was significantly lower in IMR than in corresponding HIR and FBP images. At lower radiation doses, image noise increased significantly except with IMR CR3 and IMR CS3. Visible lumen diameters were significantly larger with IMR CS than with FBP, HIR, and IMR CR. IMR CR showed the smallest attenuation difference, while attenuation was artificially decreased extensively with IMR CS. FBP and HIR showed moderately increased in-stent attenuations. No relevant influence of used radiation doses on visible lumen diameters or attenuation differences was found. Conclusion IMR CR reduces image noise significantly while offering comparable stent-specific image quality in comparison to FBP and HIR and therefore potentially facilitates stent lumen delineation. Utilization of IMR CS for stent evaluation seems unfavorable due to artificial image alterations.

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Kodeboina, Monika, Sakura Nagumo, Daniel Munhoz, Jeroen Sonck, Niya Mileva, Emanuele Gallinoro, Alessandro Candreva, et al. "Simplified Assessment of the Index of Microvascular Resistance." Journal of Interventional Cardiology 2021 (June 2, 2021): 1–7. http://dx.doi.org/10.1155/2021/9971874.

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Background. To validate a simplified invasive method for the calculation of the index of microvascular resistance (IMR). Methods. This is a prospective, single-center study of patients with chronic coronary syndromes presenting with nonobstructive coronary artery disease. IMR was obtained using both intravenous (IV) adenosine and intracoronary (IC) papaverine. Each IMR measurement was obtained in duplicate. The primary objective was the agreement between IMR acquired using adenosine and papaverine. Secondary objectives include reproducibility of IMR and time required for the IMR measurement. Results. One hundred and sixteen IMR measurements were performed in 29 patients. The mean age was 68.8 ± 7.24 years, and 27.6% was diabetics. IMR values were similar between papaverine and adenosine (17.7 ± 7.26 and 20.1 ± 8.6, p = 0.25 ; Passing-Bablok coefficient A 0.58, 95% CI −2.42 to 3.53; coefficient B 0.90, 95% CI −0.74 to 1.07). The reproducibility of IMR was excellent with both adenosine and papaverine (ICC 0.78, 95% CI 0.63 to 0.88 and ICC 0.93, 95% CI 0.87 to 0.97). The time needed for microvascular assessment was significantly shortened by the use of IC papaverine (3.23 (2.84, 3.78) mins vs. 5.48 (4.94, 7.09) mins, p < 0.0001 ). Conclusion. IMR can be reliably measured using IC papaverine with similar results compared to intravenous infusion of adenosine with increased reproducibility and reduced procedural time. This approach simplifies the invasive assessment of the coronary microcirculation in the catheterization laboratory.

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Pineda, Víctor, Jaume Figueras, Sergio Moral, Jordi Bañeras, José Rodríguez-Palomares, Artur Evangelista, and David García-Dorado. "Comparison of distinctive clinical and cardiac magnetic resonance features between ST elevation myocardial infarction patients with incomplete myocardial rupture and those with moderate to severe pericardial effusion." European Heart Journal: Acute Cardiovascular Care 8, no. 5 (July 21, 2017): 457–66. http://dx.doi.org/10.1177/2048872617719650.

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Background: Whether patients with incomplete myocardial rupture (IMR) present distinctive clinical and cardiac magnetic resonance features from those with moderate–severe pericardial effusion (⩾10 mm (PE)) remains unknown Methods: We compared the clinical, angiographic and cardiac magnetic resonance characteristics of nine patients with IMR (diagnosed angiographically and/or by cardiac magnetic resonance) with 29 with PE, and also with 38 without IMR or PE with evidence of transmural necrosis (reference group) matched for age, gender and year of admission. Results: Patients with IMR were younger than those with PE ( p<0.001) but the two groups shared a higher rate of admission delay (78% and 41%) than those without IMR/PE (5%, p<0.001) and lower frequency of reperfusion therapy (44%, 55% and 100%, respectively, p<0.001). Thirteen patients with PE (45%) but only one IMR (11%) presented recurrent chest pain. IMR patients tended to present smaller infarct size at cardiac magnetic resonance ( p=0.153 and 0.036) and number of segments with ⩾75% necrosis than PE patients and those without IMR/PE ( p=0.098 and 0.029, respectively). Ten PE patients presented cardiac tamponade (35%). A control 2D-echocardiogram performed within two years in 71 patients (93%) documented a pseudoaneurysm in one PE and in one IMR patient. Conclusions: IMR is generally silent and occurs in younger patients with smaller infarct size than those with PE although both present late and are often untreated with reperfusion therapy. These findings may warrant imaging assessment in ST elevation myocardial infarction patients with delayed admission, particularly in absence of reperfusion, to rule out an IMR.

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Adamyan, K. G., A. L. Chilingaryan, N. G. Mkrtchyan, and L. G. Tunyan. "Mechanisms and predictors of ischemic mitral regurgitation at rest and on exertion in patients at early stage of myocardial infarction." Russian Journal of Cardiology 25, no. 2 (March 11, 2020): 52–59. http://dx.doi.org/10.15829/1560-4071-2020-2-3098.

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Aim. Determination of the mechanisms and predictors of ischemic mitral regurgitation (IMR) at rest and on exertion in patients at early stage of myocardial infarction (MI).Material and methods. Seventy-seven patients with inferoposterior MI and 79 patients with anteroseptal apical MI were examined on the 7th day at rest and after exertion. We determined the degree of IMR (according to the PISA method), posteromedial and anterolateral papillary muscle (PM) displacement, closure height of the mitral valve (MV), systolic and diastolic mitral valve orifice area, volume of the left ventricle (LV), LV contractility index, deformation of the infarction regions, general LV deformation, deformation and systolic dyssinchrony of the PM.Results. IMR was more common in inferior MI (42% vs 28%). LV volumes in cases with anteroseptal apical MI and IMR were greater and LV deformation was less than in patients without IMR. In inferoposterior MI and IMR, differences were observed in the index of local contractility and function of the posteromedial PM. The differences in MI of both localizations and IMR compared with MI without IMR were the areas of the mitral orifice and dyssinchrony of the PM. The degree of IMR after exertion did not depend on the degree of IMR at rest. Predictors of IMR at rest in MI of both localizations were the apical displacement of MV closure and the area of the mitral orifice. In inferoposterior, posteromedial PM displacement, deformation of the infarcted areas, PM dyssinchrony were also predictors. In anteroseptal apical MI, the area of the mitral orifice was the predictor of IMR. Predictors of anteroseptal apical MI after physical exertion after inferior MI were mitral orifice areas, contractility index, displacement and deformation of the posteromedial PM. In anteroseptal apical MI, the IMR predictors were MV closure height and systolic area of mitral orifice.Conclusion. The study confirms the significance of changing the spatial orientation of the MV structures in MI of both localizations, impaired regional contractility in inferoposterior MI and LV volume in anteroseptal apical MI at early stage of the disease.

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Khan, Kamran, Naveedullah Khan, Faisal Qadir, Muhammad Tariq Farman, Khalid Iqbal Bhatti, and Parveen Akhtar. "FREQUENCY OF ISCHEMIC MITRAL REGURGITATION AFTER ACUTE ST- ELEVATION MYOCARDIAL INFARCTION AT A TERTIARY CARE CARDIAC CENTER." Pakistan Heart Journal 55, no. 4 (December 31, 2022): 375–79. http://dx.doi.org/10.47144/phj.v55i4.2367.

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Objectives: Among the common complications of coronary artery disease (CAD) is the ischemic mitral regurgitation (IMR). Identifying IMR and assessing its severity is pertinent owing to its significance in post- myocardial infarction (MI) risk stratification. It is associated with a higher risk of heart failure and mortality. This study aimed to determine the frequency of IMR after the first acute ST-elevation MI (STEMI) in the Pakistani population. Methodology: A cross-sectional observational study was conducted at NICVD, Karachi between January and July 2021. One hundred and ninety-five consecutive participants of first acute ST elevation MI who fulfilled the diagnostic criteria of IMR were included in the study. Demographic and clinical profile was recorded. All patients underwent echocardiography to grade the severity of IMR. Data was entered and analyzed using SPSS version 20. Results: Of 195 patients, 141 (72.3%) were males. 77 (39.5%) were diabetic, 92 (47.2%) were hypertensive, 18 (9.2%) had dyslipidemia and 58 (29.7%) used tobacco. IMR was observed in 74 (37.9%) with mild in 50 (67.6%), moderate in 18 (24.3%), and severe in 6 (8.1%) patients. IMR was statistically significantly associated with duration of symptoms, type of MI, diabetes mellitus, hypertension, and tobacco use. Conclusion: IMR was prevalent in more than one-third of patients presenting with acute ST elevation MI. Severity of IMR was moderate to severe in about one-third of the patients. IMR was found to be associated with duration of symptoms, type of MI, diabetes mellitus, hypertension, and tobacco use. Considering its prognostic role, assessment of IMR and its severity is necessary for appropriate management of patients.

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Dissertations / Theses on the topic "IMR"

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Kathiravan, Vanisree. "Morphological and spectroscopic study of human neuroblastoma IMR-32 cell differentiation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/MQ48157.pdf.

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Makri, Aikaterini, Karolos-Konstantinos Papadas, and Bodo B. Schlegelmilch. "Global-local consumer identities as drivers of global digital brand usage." Emerald Publishing Limited, 2018. http://dx.doi.org/10.1108/IMR-03-2018-0104.

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Purpose: The purpose of this paper is to represent the first empirical attempt to explore global-local consumer identities as drivers of global digital brand usage. Specifically, this study considers a unique category of digital products, social networking sites (SNS), and develops a set of hypotheses to assess the mechanism through which location-based identities influence the actual usage of global SNS (Facebook and Instagram). Moreover, cross-country variations are investigated under the lens of developed vs developing countries. Design/methodology/Approach: Cross-country surveys in a developed (Austria) and a developing country (Thailand) were conducted. Data collected from 425 young adults were analyzed using SEM techniques in order to test a set of hypotheses. Findings: Results show that in Thailand, users with a global identity enjoy participating in global SNS more than their counterparts in Austria. In addition, consumers with a local identity in Thailand demonstrate less pleasure when participating in global SNS than their counterparts in Austria, and consequently are less inclined to use global SNS. Practical implications: Findings provide digital marketers with useful insights into important strategic decisions regarding the selection and potential adaptation of global digital brands according to the country context. Originality/value: This research is the first to extend the location-based identity research in the context of global digital brands, explain how global-local identities predict SNS usage through an engagement mechanism and investigate cross-country variations of this mechanism.

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Wang, Haikou Physical Environmental &amp Mathematical Sciences Australian Defence Force Academy UNSW. "Evaluation of insect monitoring radar technology for monitoring locust migrations in inland Eastern Australia." Awarded by:University of New South Wales - Australian Defence Force Academy, 2008. http://handle.unsw.edu.au/1959.4/38923.

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To evaluate the utility of insect monitoring radar (IMR) technology for long-term monitoring of insect migration, a mini-network of two IMR units in Bourke, NSW, and Thargomindah, Qld, and a base-station server in Canberra, ACT, was set up in eastern Australia. The IMR operated automatically every night under the control of a personal computer that also conducted data acquisition and processing. Digitisation of radar signals, their analysis (delimitation of echoes from background noise and adjoining echoes, followed by extraction of estimates for each target's speed, displacement direction, body alignment, radar cross-section, and wingbeat frequency and modulation pattern), and generation of observation summaries were implemented as a fully automated procedure. Wingbeat frequency was found to be retrievable from the IMR's rotary-beam signals, and this allowed each individual target to be characterised by its wingbeat as well as its size and shape. By drawing on ancillary information from the Australian Plague Locust Commission's database of field survey and light trap records, the echo characters indicative of Australian plague locust, Chortoicetes terminifera (Walker), were identified. Using these, about 140 nights with detectable plague locust migrations were identified for the Bourke IMR site during 1998 - 2001 and 31 nights for Thargomindah during 1999 - 2000. Analysis of these nights confirmed that C. terminifera migrates in association with disturbed weather, especially tropical troughs, in eastern Australia. Trajectory simulation based on IMR-derived displacement directions and flight speeds allowed the identification of population movements likely to reach favourable habitats and thus to develop rapidly and possibly cause a plague. The outbreak during 1999 - 2001 most likely originated from the southeastern agricultural belt after migrations and multiplications over several generations. The IMR observations demonstrated that C. terminifera migrates over long distances with the wind at night and indicated that it may have an orientation behaviour that prevents it from being taken too far into the arid inland, a trait that could be highly adaptive in this environment. The two IMRs were operational for more than 85% of scheduled time during the study period and provided a wealth of information of potential value for locust management and migration research

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Baqader, N. O. A. "Characterization of mild oxidative stress response in human IMR-90 fibroblasts by subcellular quantitative proteomics." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1469041/.

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Oxidative stress is a biological state that occurs due to imbalance between reactive oxygen species (ROS) and the antioxidant system leading to subcellular disturbance. The purpose of this thesis was to determine changes in protein abundance/distribution between nuclear and cytoplasmic cell compartments in the normal human IMR90 fibroblasts subjected to mild oxidative stress. The experimental design was to exert tert- butyl hydrogen peroxide upon the IMR90 cell lines to induce mild oxidative stress followed by fractionation of the cells into nucleus and cytoplasm. Cellular response was measured by the use of subcellular spatial razor approach based on quantitative shotgun LC-MS/MS-based proteomics with SILAC isotope labeling. It has been found that, in response to the treatment, proteins were redistributed between nucleus and cytoplasm including numerous proteins that were not previously known to associate with oxidative stress. We found 121 most significant proteins with known function at unexpected subcellular location. These proteins were known to contribute to different cellular processes such as, transcription, iron/haem metabolism, TCA cycle, glycolysis, autophagy, signal transduction and ATP synthesis, and are consistent with functional networks that are spatially distributed across the cell. Specific metabolic pathways of NRF2 and proline regulatory axis were found to play an important part on the cellular response to mild oxidative stress. Iron metabolism with iron/haem as a cofactor and mitochondrial proteins were prominent into the response as well. By initial comparison of the oxidative stress fibroblasts with Cdc7 depleted fibroblasts after induction of origin activation checkpoint, it was found that both responses affect proteins related to glycolysis, TCA cycle and proline regulatory axis. Evidence suggested nuclear import/export of proteins induced by the treatment. Subcellular spatial razor results for response of fibroblasts to oxidative stress clearly suggested that, to obtain comprehensive pictures of cellular function, measurements of global changes in total protein abundance need to be combined with measurement of the dynamic subcellular spatial redistribution of proteins.

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Färdig, Rickard. "Illness Management and Recovery : Implementation and evaluation of a psychosocial program for schizophrenia and schizoaffective disorder." Doctoral thesis, Uppsala universitet, Psykiatri, Ulleråker, Akademiska sjukhuset, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175241.

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The aim of the present thesis was to examine the effectiveness of the Illness Management and Recovery (IMR) program for teaching clients with schizophrenia or schizoaffective disorder to better manage their illness and to promote recovery. This was accomplished through an examination of the program’s effects on psychosocial functioning and psychopathology, the evaluation of general and specific impact of neurocognition on learning the fundamentals of illness self-management, and the impact of symptom severity on outcome of the IMR program. The utility of the illness management and recovery scale to evaluate illness self-management of clients with schizophrenia and schizoaffective disorder was also investigated. The effects of the IMR program were evaluated in a randomized controlled trial that compared participants in the program to participants receiving treatment as usual. 41 participants were recruited at six psychiatric outpatient rehabilitation centers in Uppsala, Sweden, and were randomly assigned to IMR groups for approximately 40 sessions or to a treatment as usual control condition. The IMR program participants demonstrated greater improvement compared to participants in treatment as usual in illness self-management, reduced psychiatric symptoms, improved coping skills, and decreases in suicidal ideation. The findings suggest that the IMR program is effective in improving the ability of individuals with schizophrenia and schizoaffective disorder to better manage their illness. Possible association between neurocognitive functioning and the acquisition of illness self-management skills was investigated in a total of 53 participants who completed the IMR program. Speed of processing was related to client reported illness self-management skills acquisition, before and after controlling for psychiatric symptoms and medication, but neurocognitive functioning did not predict improvement in clinician ratings of client illness self-management skills. The findings suggest that compromised neurocognitive functioning does not reduce response to training in illness self-management. The impact of symptom severity on outcome of the IMR program was explored in 52 participants who completed the program. The results suggest that significantly more participants met the severity criterion of remission at post-treatment, and it appears that participants not reaching the severity criterion at post-treatment, also benefited from the IMR program, as indicated by the similar effect sizes of the two subgroups (meeting versus not meeting the severity criterion at post-treatment). The psychometric properties of the Illness Management and Recovery Scale (IMRS) were evaluated in 107 participants with a diagnosis of schizophrenia or schizoaffective disorder. And an item-by-item investigation was conducted in order to establish their utility in monitoring the clients' progress in the IMR program. Both the client and clinician version of the IMRS demonstrated satisfactory internal consistency, large test-retest reliability, and convergent validity with conceptually related measures of psychiatric symptoms, quality of life, and perception of recovery. The findings support the utility of the IMRS as a measure of illness self-management and recovery in clients with schizophrenia and schizoaffective disorder. The general findings of this thesis support the IMR program to be effective in improving the ability of the participants to manage their disorder. The impact of neurocognitive dysfunction on the participants’ ability to learn the fundamentals of illness self-management seems to be limited, and symptom severity did not limit the benefits of the IMR program. Support for the utility of the IMRS to monitor the participants’ progress in the program was also found, providing a brief and economical method for assessing outcome of the IMR program.
Syftet med föreliggande avhandlingsarbete var att undersöka Illness Management and Recovery (IMR) programmets effekter av att lära klienter att bättre hantera negativa konsekvenser av schizofreni eller schizoaffektiv sjukdom och att främja återhämtning. Detta åstadkoms genom en utvärdering av IMR programmets inverkan på psykosocial funktion och psykopatologi, en undersökning av specifik och generell påverkan av neurokognition avseende deltagarnas möjligheter att lära in grundläggande sjukdomshanteringsfärdigheter (illness self-management), samt en undersökning av huruvida schizofrenisymtomens svårighetsgrad inverkar på programutfallet. Vidare undersöktes Illness Management and Recovery Skalans (IMRS) användbarhet för att utvärdera sjukdomshantering och återhämtning (illness self-management and recovery) hos personer med schizofreni eller schizoaffektiv sjukdom. IMR programmets effekter utvärderades genom en randomiserad kontrollerad studie i vilken 41 programdeltagare jämfördes med deltagare i kontrollgrupp vilka fick enbart sedvanlig psykiatrisk behandling. Deltagarna rekryterades vid sex subspecialiserade psykiatriska öppenvårdsmottagningar och slumpades till att antingen delta i IMR programmet eller kontrollgrupp. IMR programmets deltagare uppvisade i jämförelse med kontrollgruppen förbättring i sjukdomshantering, minskade psykiatriska symtom, förbättrade coping-färdigheter samt minskade självmordsbeteenden. Resultaten stöder antagandet att IMR programmet är effektivt vad gäller att förbättra deltagarnas förmåga att hantera negativa effekter av schizofreni och schizoaffektiv sjukdom. Möjliga associationer mellan neurokognitiv funktion och förmågan att tillägna sig färdigheter för sjukdomshantering undersöktes hos 53 deltagare som genomförde IMR programmet. Resultaten pekar på att neurokognitiva svårigheter inte inverkar på deltagarnas möjligheter att lära sig sjukdomshantering enligt IMR modellen. Processhastighet var relaterad till klientrapporterad sjukdomshantering men inte till klinikerrapporterad sjukdomshantering. Processhastighet tycks vara relevant för klientens upplevelse av hur väl han eller hon tillägnat sig programmets strategier och färdigheter, snarare än sjukdomshantering per se. Huruvida schizofrenisymtomens svårighetsgrad inverkar på utfallet av IMR programmet undersöktes hos 52 deltagare som genomförde IMR programmet. Resultaten pekar på att signifikant fler deltagare uppfyllde svårighetsgradskriteriet för remission av schizofrenisymtom efter genomfört IMR program. Även deltagare som inte uppfyllde svårighetsgradskriteriet har nytta av IMR programmet något som indikeras av de båda gruppernas (uppfyllde jämfört med uppfyllde inte svårighetsgradskriteriet) likartade effektstorlekar. Illness Management and Recovery Skalans (IMRS) psykometriska egenskaper undersöktes för 107 deltagare med en schizofreni eller schizoaffektiv diagnos. Skalans enskilda frågor analyserades för att undersöka skalans användbarhet för att utvärdera deltagares progress och utfall i IMR programmet. Både klient och kliniker versionen av skalan uppvisade tillfredsställande intern konsistens, stor test-retest reliabilitet och konvergent validitet med konceptuellt relaterade instrument för psykiatriska symtom, livskvalité och återhämtning. Resultaten stöder antagandet att IMRS är ett användbart instrument för att utvärdera sjukdomskontroll och återhämtning för personer med schizofreni eller schizoaffektiv sjukdom. Avhandlingsarbetets resultat stöder antagandet att IMR programmet är effektivt vad gäller att förbättra deltagarnas förmåga att hantera de negativa konsekvenserna av schizofreni och schizoaffektiv sjukdom. Neurokognitiva svårigheter inverkar i begränsad utsträckning på deltagarnas möjligheter att lära sig sjukdomshantering och schizofrenisymtom tycks ha begränsad inverkan på programutfallet. Resultaten stöder även antagandet att IMRS är ett användbart instrument för att utvärdera sjukdomskontroll och återhämtning för personer med schizofreni eller schizoaffektiv sjukdom, vilket erbjuder en kortfattad och ekonomisk metod att utvärdera effekterna av IMR.

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Leporq, Benjamin. "Hépatopathies chroniques : méthodes de quantification en IRM à 1,5 T et 3,0 T pour le diagnostic et le suivi." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10279.

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La fibrose hépatique est la complication de toutes les hépatopathies chroniques et la cirrhose, correspondant à son stade évolué, est responsable d'une importante morbi-mortalité. En lien avec l'augmentation de l'incidence du diabète de type 2, des syndromes métaboliques et de l'obésité l'incidence de la stéatose hépatique non-alcoolique a considérablement augmentée au cours de ces 10 dernières années pour devenir la première cause d'hépatopathies chroniques dans les pays industrialisés. Face à une méthode de référence invasive pour le diagnostic et exposée à une importante variabilité inter et intra-observateur, aux erreurs d'échantillonnage ainsi qu'à un coût élevé, il existe un besoin clinique pour concevoir des méthodes non-invasives pour le diagnostic et le suivi des hépatopathies chroniques. Ainsi, l'objectif de ces travaux de thèse, était de proposer une méthodologie complète permettant la quantification de la graisse intra-hépatique et la quantification de la fibrose par IRM à 1,5 et 3,0 T. Pour la quantification de la fibrose, une méthode permettant la réalisation de cartographies des paramètres hémodynamiques hépatiques en imagerie de perfusion a été développée à 1,5 T. Ensuite, dans l'idée d'utiliser une approche multiparamétrique, nous avons optimisé un protocole permettant l'imagerie du mouvement incohérent intra-voxel (IVIM) sur le foie afin de l'associer à l'imagerie de perfusion à 3,0 T. Concernant la quantification de la graisse intra-hépatique, une méthode incluant une correction des effets des temps de relaxation par estimation séparée des valeurs de T1 et T2* des protons de l'eau et des lipides, une prise en compte des 5 composantes spectrales principales des lipides, ainsi qu'une procédure permettant la levée de l'ambigüité des composantes dominantes a été développée et évaluée à 1,5 et 3,0 T. Les paramètres hémodynamiques hépatiques quantifiés, en particulier le débit portal et l'index de perfusion hépatique, permettent d'établir la distinction entre l'absence de fibrose, une fibrose débutante, une fibrose avancée et une cirrhose. Pour la quantification de la graisse, la fraction volumique de graisse (FVG) donnée par notre méthode permet de quantifier de manière précise la quantité de graisse intra-hépatique en s'affranchissant des différents facteurs pouvant biaiser l’estimation. Par ailleurs, la FVG permet la distinction entre les différents stades histologiques de stéatose avec une excellente sensibilité/spécificité. L'association de l'imagerie de perfusion avec l'imagerie du mouvement incohérent intra-voxel est en cours d'évaluation à travers l'étude HEPATOMAP qui combine toute la méthodologie développée. Les résultats préliminaires de cette étude ont déjà permis de montrer que l'association entre l'IVIM et la méthode de quantification de la graisse permet de distinguer entre la stéatose pure et la stéato-hépatite
Liver fibrosis is the main complication of chronic liver diseases, and cirrhosis, corresponding to the end-stage of fibrosis, is an important cause of morbi-mortality. The incidence increase of diabetes, metabolism disorders and obesity involve an increase of NAFLD which became the first cause of chronic liver disease in western countries. Since liver biopsy is the gold standard for the diagnosis of chronic liver diseases, inherent risks, intra- and inter-observer variability associated to an important cost motivate a clinical need to develop non-invasive methods for chronic liver disease assessment. Thus, the aim of this PhD thesis was to develop a method allowing the quantification of fat liver content and liver fibrosis using MRI at 1.5 and 3.0 T. For liver fibrosis quantification a method allowing liver perfusion parameters mapping using a MR dynamic contrast enhanced method was developed at 1.5 T. Then, in order to use a multi-parametric approach, a protocol allowing intra-voxel incoherent motion imaging (IVIM) was optimized at 3.0T. The aim was to combine liver perfusion imaging and IVIM. Regarding liver fat content quantification, a method including a correction of relaxation time effects using a disjointed estimation of T1 and T2* relaxation times of fat and water, accounting for the NMR spectrum of fat and resolving the dominant component ambiguity problem was developed. Liver perfusion parameters, in particularly portal perfusion and hepatic perfusion index were found relevant to make the distinction between no fibrosis, non-advanced fibrosis, advanced fibrosis and cirrhosis. About liver fat content quantification, fat volume fraction (FVF) given by our method allowed to quantify liver fat content accurately without cofounding factor-related bias. Moreover, FVF allowed diagnosing histological grade of steatosis with an excellent sensitivity/specificity. Combination of liver perfusion imaging and IVIM is actually under evaluation through the HEPATOMAP study using all the methodology developed through this PhD thesis. Preliminary results of this study have shown that the combination of information acquired with both the fat quantification and IVIM methods could allow distinction between NAFLD and NASH

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Rossi, Alessandro. "Caratterizzazione di resine epossidiche per materiali compositi realizzati in infusione ad alta pressione." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016.

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I materiali compositi, grazie alla combinazione delle proprietà dei singoli componenti di cui sono costituiti, in particolare la coesistenza di elevate caratteristiche meccaniche e pesi ridotti, rivestono da tempo un ruolo fondamentale nell’industria aeronautica e nel settore delle competizioni automobilistiche e motociclistiche. La possibilità di progettare i materiali in funzione della loro applicazione, unita alla riduzione dei costi di produzione, permette una crescente diffusione del loro utilizzo e l’ampliamento delle applicazioni a moltissimi altri settori, sia per componenti di tipo strutturale, sia di tipo estetico. L’obiettivo della presente tesi è analizzare, attraverso una campagna sperimentale, il comportamento di diversi materiali realizzati con la tecnica di produzione HP-RTM, tramite prove di taglio interlaminare e flessione, al fine di verificare l’applicabilità di tale processo a prodotti strutturali, in modo da velocizzare i tempi di produzione e quindi di abbassare i costi, mantenendo al tempo stesso elevate proprietà meccaniche. Lo scopo di questa campagna quindi è fornire, attraverso lo studio di 30 serie di provini, il materiale migliore in termini di resistenza a flessione e taglio interlaminare; inoltre per ogni tipologia di materiale vengono descritte le diverse distribuzioni dei valori di rottura riscontrati, in modo da lasciare al progettista più libertà possibile nella scelta del materiale in base alle specifiche richieste per una determinata applicazione. Questo studio permette di analizzare l’influenza di ogni singolo componente (tipo di fibra, tipo di binder, presenza o assenza di IMR), all’interno della stessa resina.

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Dean, Timothy J. Physical Environmental &amp Mathematical Sciences Australian Defence Force Academy UNSW. "Development and evaluation of automated radar systems for monitoring and characterising echoes from insect targets." Awarded by:University of New South Wales - Australian Defence Force Academy. School of Physical, Environmental and Mathematical Sciences, 2007. http://handle.unsw.edu.au/1959.4/38667.

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This thesis describes the construction of a mobile Insect Monitoring Radars (IMR) and investigations of: the reliability of IMRs for observing insect migration in inland Australia; possible biases in IMR migration estimates; the relation between an insect???s size and its radar properties; radar discrimination between insect species; the effect of weather on the migrations of Australian plague locusts and of moths; the scale of these migrations; and here IMRs are best located. The principles of entomological radar design, and the main features of insect migration in inland Australia, are reviewed. The main procedures used in the study are: calculation of radar performance and of insect radar cross sections (RCSs); reanalysis of a laboratory RCS dataset; statistical analysis of a fouryear dataset of IMR and weather observations; and a field campaign using both two existing fixed IMRs and the new mobile unit. Statistical techniques used include correlation, multiple regression, discriminant analysis, and principal components analysis. The original results of this work include design details of the mobile IMR, extension of radar performance calculations to IMRs and evaluation of flight speed biases, a holistic approach to IMR design, the relation of insect RCS magnitudes and polarization patterns to morphological variables, an estimate of the accuracy of the retrieved parameters, evaluations of three approaches (oneparameter, theory-based, and a novel two-stage method) to target identification, and verification of inferred target identities using results from nearby light traps. Possible sites for future IMRs are identified. The major conclusions are that: a mobile IMR can be built with a performance equal to that of a fixed IMR but at half the cost; significant biases in the signal processing results arise from insect speed; locusts and moths can be distinguished if all RCS parameters are used; IMRs can be designed to match particular requirements; weather has a significant effect on insect migration, the best single predictor of insect numbers being temperature; moonlight has no effect; the spatial correlation of migration properties falls to 50% at a separation of 300 km; and migrating insects can be carried by the wind for 500 km in a single night

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Capelli, Laurent. "Etude des dimuons de la région des masses intermédiaires produits dans les collisions d'ions lourds auprès du SPS du CERN." Phd thesis, Université Claude Bernard - Lyon I, 2001. http://tel.archives-ouvertes.fr/tel-00000703.

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Dans cette thèse, nous étudions la production des dimuons dans une région de masse entre les résonances Phi et J/Psi (Région des Masses Intermédiaires, IMR) dans les collisions proton-noyau et noyau-noyau de haute énergie.

L'expérience NA50, installée auprès de l'accélérateur SPS du CERN, détecte les paires de muons émises dans ces interactions au moyen d'un spectromètre spécifique. La mesure de la centralité des collisions repose sur trois détecteurs indépendants : un calorimètre électromagnétique, un détecteur de multiplicité et un calorimètre à zéro degré.

Les résultats des analyses proton-noyau fournissent une valeur de référence pour l'étude des interactions noyau-noyau. Les distributions expérimentales, corrigées de l'acceptance et de la résolution par une méthode quadri-dimensionnelle, des dimuons IMR sont correctement reproduites par la superposition des processus conventionnels DY et DDbar (désintégration des mésons charmés). L'extrapolation linéaire avec le nombre de masse des noyaux des résultats p-A aux collisions S-U et Pb-Pb, sous-estime systématiquement les spectres mesurés dans la région des masses intermédiaires.

Cet excès de dimuons IMR augmente avec la centralité des collisions. Plusieurs modèles théoriques sont présentés et comparés aux données noyau-noyau. Nous montrons qu'un modèle basé sur la diffusion des mésons D et Dbar dans l'état final ne reproduit pas les distributions expérimentales. Finalement, cette étude permet de proposer deux explications possibles de l'excès observé. Les spectres noyau-noyau peuvent être reproduits soit par une augmentation de la production de charme soit par la présence de dimuons thermiques émis par un milieu dense et chaud.

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Butscheidt, Sebastian Karl [Verfasser], and Marc [Akademischer Betreuer] Regier. "Einfluss des neuen iterativen Rekonstruktionsverfahrens „Iterative Model Reconstruction“ (IMR) auf die Abgrenzbarkeit normaler und pathologischer Lungenstrukturen in der Niedrigdosis- Thorax-CT im Vergleich zu iDose4TM und der herkömmlichen gefilterten Rückprojektion (FBP) / Sebastian Karl Butscheidt ; Betreuer: Marc Regier." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1121207154/34.

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Books on the topic "IMR"

1

Pengembangan, Riau (Indonesia :. Province) Badan Penelitian dan. Study/survey MMR-IMR dan indikator-indikator derajad kesehatan tahun 2007. Pekanbaru]: Badan Penelitian dan Pengembangan, Provinsi Riau, 2008.

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R, Walker James. IMR sourcebook: A comprehensive guide to the world of metal repair, preservation, and conservation ... Escondido, CA: Institute of Metal Repair, 1989.

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Rodney, Phillips, and UNICEF, eds. A reduction in IMR from 162 to 24 (per thousand) in 45 years: The Mauritius story. Port Louis, Mauritius: Unicef, 1986.

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Wong, Reginald. A reduction in IMR from 162 to 24 (per thousand) in 45 years: The Mauritius story. Port Louis, Mauritius: UNICEF, 1986.

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Mahapatra, Prasanta. District Family Health Survey (DFHS), 2000: A pilot study in three districts of Andhra Pradesh to estimate IMR, fertility, and maternal mortality. Hyderabad: Institute of Health Systems, 2001.

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Ḳalṿarisḳi-Herman, Rami. Ima odṿagah: (imi ha-amitsah). Loḥame ha-Geṭaʼot: Bet Loḥame ha-Geṭaʼot, Hotsaʼah le-or Be-yaḥad, 2009.

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International Workshop on Application of Submillimeter Wave Electron Spin Resonance for Novel Magnetic Systems (2002 Tohoku University). Proceedings of the International Workshop on Application of Submillimeter Wave Electron Spin Resonance for Novel Magnetic Systems: June 13-14, 2002, IMR, Tohoku University, Sendai, Japan. Edited by Ohta Hitoshi, Nojiri Hiroyuki, Motokawa M, and Tōhoku Daigaku. Kinzoku Zairyō Kenkyūjo. Tokyo, Japan: Physical Society of Japan, 2003.

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Jiyū to kokka: Ima "kenpō" no motsu imi. Tōkyō: Iwanami Shoten, 1989.

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Shimizu, Shūji. Genpatsu to wa kekkyoku nan datta no ka: Ima Fukushima de ikiru imi. Tōkyō: Tōkyō Shinbun, 2012.

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Ima fa Ima. Nairobi: Jomo Kenyatta Foundation, 2007.

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Book chapters on the topic "IMR"

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Gudmundsson, Larus S., Olafur B. Einarsson, and Magnus Johannsson. "Icelandic Medicines Registry (IMR)." In Databases for Pharmacoepidemiological Research, 205–11. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51455-6_17.

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Qin, Fengxiang, Zhenhua Dan, Wei Zhang, Soyalatu, Mitsuo Niinomi, Takeyuki Nakamoto, Takahiro Kimura, and Takashi Nakajima. "Functional Materials Developed in IMR." In Novel Structured Metallic and Inorganic Materials, 89–103. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-7611-5_5.

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Al Sharkawy, Mohamed H., Veysel Demir, and Atef Z. Elsherbeni. "Combined Multigrid Technique and IMR Algorithm." In Electromagnetic Scattering Using the Iterative Multiregion Technique, 75–85. Cham: Springer International Publishing, 2007. http://dx.doi.org/10.1007/978-3-031-01702-5_7.

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Warnholtz, Ascan, and Tommaso Gori. "Threshold FFR, Impaired CFR, and IMR: Macrovascular or Microvascular Disease?" In Atlas of FFR-Guided Percutaneous Coronary Interventions, 179–82. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-47116-7_34.

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Al Sharkawy, Mohamed H., Veysel Demir, and Atef Z. Elsherbeni. "IMR Technique for Large-Scale Electromagnetic Scattering Problems:2D Case." In Electromagnetic Scattering Using the Iterative Multiregion Technique, 39–53. Cham: Springer International Publishing, 2007. http://dx.doi.org/10.1007/978-3-031-01702-5_4.

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Al Sharkawy, Mohamed H., Veysel Demir, and Atef Z. Elsherbeni. "The IMR Algorithm Using a Hybrid FDFD and Method of Moments Techniques." In Electromagnetic Scattering Using the Iterative Multiregion Technique, 55–64. Cham: Springer International Publishing, 2007. http://dx.doi.org/10.1007/978-3-031-01702-5_5.

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Choi, Moonsuk, Seongho Ju, Yonghun Lim, and Jong-mock Baek. "Design and Performance Analysis of Automatic Wireless Routing Mechanism for the Effective Formation of IMR (Integrated Meter Reading) Network." In Communication and Networking, 493–500. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-10844-0_57.

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Krishnamoorthy, P., and D. Kalaiselvan. "Apoptosis Activity of 1,2,-Benzene Dicarboxylic Acid Isolated from Andrographis paniculata on KB, SiHa and IMR Cancer Cell Line." In Drug Development for Cancer and Diabetes, 129–39. Includes bibliographical references and index.: Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429330490-11.

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Götze, Karl Heinz. "Nochmals über die Liebe von Madame Bovary." In »Madame Bovary, c'est nous!« - Lektüren eines Jahrhundertromans, 45–54. Bielefeld, Germany: transcript Verlag, 2021. http://dx.doi.org/10.14361/9783839452844-004.

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Götze untersucht in diesem Beitrag folgende Fragen: Erstens: Warum macht der Liebesroman der Emma Bovary bis heute soviel Unbehagen? Zweitens: Was eigentlich sucht Emma in der Liebe, warum ist sie ihr so wichtig, dass sie ihr erst ihr bürgerliches und schließlich ihr nacktes Leben preisgibt? Drittens: Warum scheitert Emmas Liebesleben und damit am Ende ihr Leben eigentlich überhaupt? Am Ende die Frage danach, welche Liebesgeschichte Emma Rouaud, verheiratete Bovary, wohl heute erleben würde. Liebte sie wohl besser heute? Ginge ihre Geschichte besser aus? Wo sind Fortschritte der Freiheit zu lieben zu konstatieren - und wo Verluste?

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Fischer, R. X., and W. H. Baur. "IMF." In Zeolite-Type Crystal Structures and their Chemistry. 41 New Framework Type Codes, 180–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41452-7_15.

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Conference papers on the topic "IMR"

1

Hurley, Michael F. "Structural RIM IMR." In International Congress & Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1990. http://dx.doi.org/10.4271/900305.

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Tito, Nicolas, and Eric Rambaldi. "SWIMMER: Innovative IMR AUV." In Offshore Technology Conference. Offshore Technology Conference, 2009. http://dx.doi.org/10.4043/19930-ms.

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Itagaki, Y., A. Suzuki, and K. Higashio. "TISSUE PLASMINOGEN ACTIVATOR (T-PA) PRODUCTION BY HUMAN EMBRYONIC FIBROBLASTS, IMR-90, STIMULATED BY PROTEOSE PEPTONE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644392.

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In order to study the mechanisms by which t-PA production by IMR-90 cells are induced, lactalbumin hydrolysates, yeast extracts, and peptones were tested for their ability to induce t-PA production by IMR-90 cells. IMR-90 cells were grown to confluency in Dulbecco's modified Eagle's medium(DMEM) supplemented with 10% fetal calf serum at 37°C in 5% CO2 in air. And the cells were maintained in serum free medium containing 1% of each additive. The plasminogen activator activity was determined by fibrin plate method, using urokinase or t-PA from WHO as a standard. It was found that proteose peptone (Difco) and neopeptone (Difco) strongly induced the t-PA production by IMR-90 cells. The t-PA production in DMEM containing 1% proteose peptone reached approx. 200IU/ml after incubation at 37°C for 6 days and was from twenty to fifty times higher than that in DMEM only (control medium). The t-PA production by IMR-90 cells stimulated by proteose peptone was strongly inhibited by RNA synthesis inhibitor(actinomycin D) or prorein synthesis inhibitor (cycloheximide). Hence, t-PA production by IMR-90 cells stimulated by proteose peptone was mediated by de novo synthesis. Chelating reagent (EGTA), Ca2+ entry blocker (verapamil), inhibitor of phospholipase A2 (quinacrine) and inhibitor of lipoxygenase (NDGA) strongly inhibited the t-PA production by IMR-90 cells stimulated by proteose peptone. Inhibitor of cyclooxygenase (indomethacin) was inert. On the contrary, activators of phospholipase A2(Ca2+,melittin) and hydroxy-unsaturated fatty acid (5-HETE) derived from arachidonic acid by lipoxygenase strongly enhanced t-PA production by IMR-90 cells stimulated by proteose peptone. These results suggest that the t-PA production by IMR-90 cells stimulated by proteose peptone is mediated by arachidonate cascade involving the following pathway; (1) proteose peptone stimulates the membrane of IMR-90, (2) this stimulus causes Ca2+ influx, (3) Ca2+ ion activates phopholipase A2, (4) activated phospholipase A2 liberates arachidonic acid from phospholipids in ceil membrane and (5) lipoxygenase converts arachidonic acid into the hydroxy-unsaturated fatty acid.

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Hong, Chin-Yih, Shieh-Yueh Yang, K. W. Huang, Herng-Er Horng, and Hong-Chang Yang. "In-Vitro Diagnosis of Colon Cancer Using Bio-Functionalized Magnetic Nanoparticles." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-47178.

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The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development.

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Kanagawa, Takashi, Masashi Goto, Shuji Usui, Tadahiko Suzuta, Akimi Serizawa, Tomoaki Kunugi, Tetsuo Matsumura, Toyoaki Yamauchi, and Gen Itoh. "The Design Features of Integrated Modular Water Reactor (IMR)." In 12th International Conference on Nuclear Engineering. ASMEDC, 2004. http://dx.doi.org/10.1115/icone12-49528.

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Small-to-medium-sized (300–600MWe) reactors are required for the electric power market in the near future (2010–2030). The main theme in the development of small-to-medium-sized reactor is how to realize competitive cost against other energy sources. As measures to this disadvantage, greatly simplified and downsized design is needed. From such point of view, Integrated Modular Water Reactor (IMR), which electric output power is 350 MWe, adopts integrated and high temperature two-phase natural circulation system for the primary system. In this design, main coolant pipes, a pressurizer, and reactor coolant pumps are not needed, and the sizes of a reactor vessel and steam generators are minimized. Additionally, to enhance the economy of the whole plant, fluid system, and Instrumentation & Control system of IMR have also been reviewed to make them simplest and smallest taking the advantage of the IMR concept and the state of the art technologies. For example, the integrated primary system and the stand-alone direct heat removal system make the safety system very simple, i.e., no injection, no containment spray, no emergency AC power, etc. The chemical and volume control system is also simplified by eliminating the boron control system and the seal water system of reactor coolant pumps. In this paper, the status of the IMR development and the outline of the IMR design efforts to achieve the simplest and smallest plant are presented.

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Rausch, Manuel K., Frederick A. Tibayan, D. Craig Miller, and Ellen Kuhl. "Chronic Mitral Valve Leaflet Growth Following Myocardial Infarction." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80308.

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One of the primary failure modes of the mitral valve is mitral regurgitation (MR). MR often follows myocardial infarction, in which case it is referred to as ischemic mitral regurgitation (IMR). IMR is a result of alterations to the annular and subvalvular apparatus secondary to left ventricular remodeling [1]. Recent studies showed that the mitral valve can adapt to IMR by increasing leaflet size to reduce the degree of regurgitation. Understanding the exact biomechanical and biochemical mechanisms behind mitral valve adaptation may open new treatment strategies for patients with mitral regurgitation [2]. In this study [3], we investigated the phenomenon of mitral valve leaflet “growth” in an ovine model to define the mechanisms that drive the “growth” process. We further quantified regional and directional variations in “growth” across the anterior mitral valve leaflet (AMVL).

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Hong, Chin-Yih, Shieh-Yueh Yang, Herng-Er Horng, Jen-Jie Chieh, and Hong-Chang Yang. "Universal Behavior for Characteristic Curve of Immunomagnetic Reduction Assay With Aid of Biofunctionalized Magnetic Nanoparticles." In ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/detc2009-86436.

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By biofunctionalizing magnetic nanoparticles with bioprobes, magnetic nanoparticles are able to specifically label bio-molecules. With the association between magnetic nanoparticles and bio-molecules, the mixed-frequency AC magnetic susceptibility generated with the physical rotation of individual magnetic nanoparticles under external AC magnetic fields is reduced. This detection technology is so-called immunomagnetic reduction (IMR) assay. In the experiment, several kinds of proteins and small-molecule chemicals were detected via IMR. The characteristic curves, i.e. the reduction versus the concentration of protein/chemical, for these proteins or chemicals can be scaled to one universal curve.

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Tan, Qingxiong, Mang Ye, Grace Lai-Hung Wong, and PongChi Yuen. "Cooperative Joint Attentive Network for Patient Outcome Prediction on Irregular Multi-Rate Multivariate Health Data." In Thirtieth International Joint Conference on Artificial Intelligence {IJCAI-21}. California: International Joint Conferences on Artificial Intelligence Organization, 2021. http://dx.doi.org/10.24963/ijcai.2021/219.

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Due to the dynamic health status of patients and discrepant stability of physiological variables, health data often presents as irregular multi-rate multivariate time series (IMR-MTS) with significantly varying sampling rates. Existing methods mainly study changes of IMR-MTS values in the time domain, without considering their different dominant frequencies and varying data quality. Hence, we propose a novel Cooperative Joint Attentive Network (CJANet) to analyze IMR-MTS in frequency domain, which adaptively handling discrepant dominant frequencies while tackling diverse data qualities caused by irregular sampling. In particular, novel dual-channel joint attention is designed to jointly identify important magnitude and phase signals while detecting their dominant frequencies, automatically enlarging the positive influence of key variables and frequencies. Furthermore, a new cooperative learning module is introduced to enhance information exchange between magnitude and phase channels, effectively integrating global signals to optimize the network. A frequency-aware fusion strategy is finally designed to aggregate the learned features. Extensive experimental results on real-world medical datasets indicate that CJANet significantly outperforms existing methods and provides highly interpretable results.

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Bahloul, Neila, M. A. Balti, M. S. Guellouze, and Nabil Kechaou. "Coupling of microwave radiations to convective drying for improving fruit quality." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7794.

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The present study aims to find the best drying method to minimize the duration of the operation while respecting the nutritional value of the product. Experiments of convective drying and microwave radiation were respectively carried out with a convective dryer (heat temperature: 65 °C and air velocity: 1.3 m/s) and a microwave oven (power level: 100 W and frequency: 2450 MHz). Six coupling tests between the convective drying and microwave radiation were conducted. The only variable condition is the time output of tomatoes from the convective dryer or the microwave oven corresponding to an intermediate mass ratio (IMR) 0.5, 0.4 and 0.3. The microwave drying removes the bound water faster than convective drying. This explains the observed time savings due to convection-microwave and microwave-convection combined drying. The combination of convection drying and microwave drying to an IMR 0.5 preserved better the red color and the antioxidants of the tomato. Thus, the convection–microwave combined drying (IMR 0.5) proved most suitable for preserving the quality of tomatoes. Keywords: convective drying; microwave; coupled drying; color.

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Liljeback, Pal, and Richard Mills. "Eelume: A flexible and subsea resident IMR vehicle." In OCEANS 2017 - Aberdeen. IEEE, 2017. http://dx.doi.org/10.1109/oceanse.2017.8084826.

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Reports on the topic "IMR"

1

Deng, S. ASPECTS OF THE MECHNANICAL BEHAVIOR OF STITCHED T300 MAT/URETHANE 420 IMR COMPOSITE. Office of Scientific and Technical Information (OSTI), November 2002. http://dx.doi.org/10.2172/814477.

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Deng, S. MECHANICAL RESPONSE OF STITCHED T300 MAT/URETHANE 420 IMR COMPOSITE LAMINATES: PROPERTY/ORIENTATION DEPENDENCE AND DAMAGE EVOLUTION. Office of Scientific and Technical Information (OSTI), May 2000. http://dx.doi.org/10.2172/885636.

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Deng, S., and Y. J. Weitsman. Mechanical Response of Stitched T300 Mat/Urethane 420 IMR Composite Laminates: Property/Orientation Dependence and Damage Evolution. Office of Scientific and Technical Information (OSTI), March 2000. http://dx.doi.org/10.2172/768802.

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Moores, Lee, Alan Kennedy, Lauren May, Shinita Jordan, Anthony Bednar, Stacy Jones, David Henderson, Luke Gurtowski, and Kurt Gust. Identifying degradation products responsible for increased toxicity of UV-degraded insensitive munitions. Engineer Research and Development Center (U.S.), September 2021. http://dx.doi.org/10.21079/11681/42020.

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Degradation of insensitive munitions (IMs) by ultraviolet (UV) light has become a concern following observations that some UV-degradation products have increased toxicity relative to parent compounds in aquatic organisms. This investigation focused on the Army's IM formulation, IMX-101, composed of three IM constituents: 2,4-dinitroanisole (DNAN), 3-nitro-1,2,4-triazol-5-one (NTO), and nitroguanidine (NQ). The IM constituents and IMX-101 were irradiated in a UV photo-reactor and then administered to Daphnia pulex in acute (48 h) exposures comparing toxicities relative to the parent materials. UV-degradation of DNAN had little effect on mortality whereas mortality for UV-degraded NTO and NQ increased by factors of 40.3 and 1240, making UV-degraded NQ the principle driver of toxicity when IMX-101 is UV-degraded. Toxicity investigations for specific products formed during UV-degradation of NQ, confirmed greater toxicity than the parent NQ for degradation products. Summation of the individual toxic units for the complete set of individually measured UV-degradation products identified for NQ only accounted for 25% of the overall toxicity measured in the exposures to the UV-degraded NQ product mixture. Given the underestimation of toxicity using the sum toxic units for the individually measured UV-degradation products of NQ, we conclude that: (1) other unidentified NQ degradation products contributed principally to toxicity and/or (2) synergistic toxicological interactions occurred among the NQ degradation product mixture that exacerbated toxicity.

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Briffa, Norman. IMA Harvesting. Touch Surgery Simulations, February 2015. http://dx.doi.org/10.18556/touchsurgery/2015.s0039.

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McGrath, Christian, Beth Porter, Jonathon Brame, Mark Chappell, and Amber Russell. Dissolution kinetics of IMX-101 and IMX 104 : Operating Procedure series : characterization of IMX dissolution. Environmental Laboratory (U.S.), July 2016. http://dx.doi.org/10.21079/11681/22177.

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Morse, Rachel M. ISR All Hands. Office of Scientific and Technical Information (OSTI), July 2017. http://dx.doi.org/10.2172/1373511.

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RODACY, PHILIP J., STEPHEN D. REBER, ROBERT J. SIMONSON, and BRADLEY G. HANCE. IMS applications analysis. Office of Scientific and Technical Information (OSTI), March 2000. http://dx.doi.org/10.2172/752625.

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Ahrens, Toby, and Leslie Van der Meulen. Mixo-IBR BP1A Report. Office of Scientific and Technical Information (OSTI), February 2016. http://dx.doi.org/10.2172/1398771.

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Gentile, N. Smoothed Emission for IMC. Office of Scientific and Technical Information (OSTI), January 2011. http://dx.doi.org/10.2172/1018761.

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