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Kathiravan, Vanisree. "Morphological and spectroscopic study of human neuroblastoma IMR-32 cell differentiation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/MQ48157.pdf.
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Makri, Aikaterini, Karolos-Konstantinos Papadas, and Bodo B. Schlegelmilch. "Global-local consumer identities as drivers of global digital brand usage." Emerald Publishing Limited, 2018. http://dx.doi.org/10.1108/IMR-03-2018-0104.
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Purpose: The purpose of this paper is to represent the first empirical attempt to explore global-local consumer
identities as drivers of global digital brand usage. Specifically, this study considers a unique category of digital
products, social networking sites (SNS), and develops a set of hypotheses to assess the mechanism through
which location-based identities influence the actual usage of global SNS (Facebook and Instagram).
Moreover, cross-country variations are investigated under the lens of developed vs developing countries.
Design/methodology/Approach: Cross-country surveys in a developed (Austria) and a developing
country (Thailand) were conducted. Data collected from 425 young adults were analyzed using SEM
techniques in order to test a set of hypotheses.
Findings: Results show that in Thailand, users with a global identity enjoy participating in global SNS
more than their counterparts in Austria. In addition, consumers with a local identity in Thailand demonstrate
less pleasure when participating in global SNS than their counterparts in Austria, and consequently are less
inclined to use global SNS.
Practical implications: Findings provide digital marketers with useful insights into important strategic
decisions regarding the selection and potential adaptation of global digital brands according to the country context.
Originality/value: This research is the first to extend the location-based identity research in the context of
global digital brands, explain how global-local identities predict SNS usage through an engagement
mechanism and investigate cross-country variations of this mechanism.
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Wang, Haikou Physical Environmental & Mathematical Sciences Australian Defence Force Academy UNSW. "Evaluation of insect monitoring radar technology for monitoring locust migrations in inland Eastern Australia." Awarded by:University of New South Wales - Australian Defence Force Academy, 2008. http://handle.unsw.edu.au/1959.4/38923.
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To evaluate the utility of insect monitoring radar (IMR) technology for long-term monitoring of insect migration, a mini-network of two IMR units in Bourke, NSW, and Thargomindah, Qld, and a base-station server in Canberra, ACT, was set up in eastern Australia. The IMR operated automatically every night under the control of a personal computer that also conducted data acquisition and processing. Digitisation of radar signals, their analysis (delimitation of echoes from background noise and adjoining echoes, followed by extraction of estimates for each target's speed, displacement direction, body alignment, radar cross-section, and wingbeat frequency and modulation pattern), and generation of observation summaries were implemented as a fully automated procedure. Wingbeat frequency was found to be retrievable from the IMR's rotary-beam signals, and this allowed each individual target to be characterised by its wingbeat as well as its size and shape. By drawing on ancillary information from the Australian Plague Locust Commission's database of field survey and light trap records, the echo characters indicative of Australian plague locust, Chortoicetes terminifera (Walker), were identified. Using these, about 140 nights with detectable plague locust migrations were identified for the Bourke IMR site during 1998 - 2001 and 31 nights for Thargomindah during 1999 - 2000. Analysis of these nights confirmed that C. terminifera migrates in association with disturbed weather, especially tropical troughs, in eastern Australia. Trajectory simulation based on IMR-derived displacement directions and flight speeds allowed the identification of population movements likely to reach favourable habitats and thus to develop rapidly and possibly cause a plague. The outbreak during 1999 - 2001 most likely originated from the southeastern agricultural belt after migrations and multiplications over several generations. The IMR observations demonstrated that C. terminifera migrates over long distances with the wind at night and indicated that it may have an orientation behaviour that prevents it from being taken too far into the arid inland, a trait that could be highly adaptive in this environment. The two IMRs were operational for more than 85% of scheduled time during the study period and provided a wealth of information of potential value for locust management and migration research
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Baqader, N. O. A. "Characterization of mild oxidative stress response in human IMR-90 fibroblasts by subcellular quantitative proteomics." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1469041/.
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Oxidative stress is a biological state that occurs due to imbalance between reactive oxygen species (ROS) and the antioxidant system leading to subcellular disturbance. The purpose of this thesis was to determine changes in protein abundance/distribution between nuclear and cytoplasmic cell compartments in the normal human IMR90 fibroblasts subjected to mild oxidative stress. The experimental design was to exert tert- butyl hydrogen peroxide upon the IMR90 cell lines to induce mild oxidative stress followed by fractionation of the cells into nucleus and cytoplasm. Cellular response was measured by the use of subcellular spatial razor approach based on quantitative shotgun LC-MS/MS-based proteomics with SILAC isotope labeling. It has been found that, in response to the treatment, proteins were redistributed between nucleus and cytoplasm including numerous proteins that were not previously known to associate with oxidative stress. We found 121 most significant proteins with known function at unexpected subcellular location. These proteins were known to contribute to different cellular processes such as, transcription, iron/haem metabolism, TCA cycle, glycolysis, autophagy, signal transduction and ATP synthesis, and are consistent with functional networks that are spatially distributed across the cell. Specific metabolic pathways of NRF2 and proline regulatory axis were found to play an important part on the cellular response to mild oxidative stress. Iron metabolism with iron/haem as a cofactor and mitochondrial proteins were prominent into the response as well. By initial comparison of the oxidative stress fibroblasts with Cdc7 depleted fibroblasts after induction of origin activation checkpoint, it was found that both responses affect proteins related to glycolysis, TCA cycle and proline regulatory axis. Evidence suggested nuclear import/export of proteins induced by the treatment. Subcellular spatial razor results for response of fibroblasts to oxidative stress clearly suggested that, to obtain comprehensive pictures of cellular function, measurements of global changes in total protein abundance need to be combined with measurement of the dynamic subcellular spatial redistribution of proteins.
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Färdig, Rickard. "Illness Management and Recovery : Implementation and evaluation of a psychosocial program for schizophrenia and schizoaffective disorder." Doctoral thesis, Uppsala universitet, Psykiatri, Ulleråker, Akademiska sjukhuset, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175241.
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The aim of the present thesis was to examine the effectiveness of the Illness Management and Recovery (IMR) program for teaching clients with schizophrenia or schizoaffective disorder to better manage their illness and to promote recovery. This was accomplished through an examination of the program’s effects on psychosocial functioning and psychopathology, the evaluation of general and specific impact of neurocognition on learning the fundamentals of illness self-management, and the impact of symptom severity on outcome of the IMR program. The utility of the illness management and recovery scale to evaluate illness self-management of clients with schizophrenia and schizoaffective disorder was also investigated. The effects of the IMR program were evaluated in a randomized controlled trial that compared participants in the program to participants receiving treatment as usual. 41 participants were recruited at six psychiatric outpatient rehabilitation centers in Uppsala, Sweden, and were randomly assigned to IMR groups for approximately 40 sessions or to a treatment as usual control condition. The IMR program participants demonstrated greater improvement compared to participants in treatment as usual in illness self-management, reduced psychiatric symptoms, improved coping skills, and decreases in suicidal ideation. The findings suggest that the IMR program is effective in improving the ability of individuals with schizophrenia and schizoaffective disorder to better manage their illness. Possible association between neurocognitive functioning and the acquisition of illness self-management skills was investigated in a total of 53 participants who completed the IMR program. Speed of processing was related to client reported illness self-management skills acquisition, before and after controlling for psychiatric symptoms and medication, but neurocognitive functioning did not predict improvement in clinician ratings of client illness self-management skills. The findings suggest that compromised neurocognitive functioning does not reduce response to training in illness self-management. The impact of symptom severity on outcome of the IMR program was explored in 52 participants who completed the program. The results suggest that significantly more participants met the severity criterion of remission at post-treatment, and it appears that participants not reaching the severity criterion at post-treatment, also benefited from the IMR program, as indicated by the similar effect sizes of the two subgroups (meeting versus not meeting the severity criterion at post-treatment). The psychometric properties of the Illness Management and Recovery Scale (IMRS) were evaluated in 107 participants with a diagnosis of schizophrenia or schizoaffective disorder. And an item-by-item investigation was conducted in order to establish their utility in monitoring the clients' progress in the IMR program. Both the client and clinician version of the IMRS demonstrated satisfactory internal consistency, large test-retest reliability, and convergent validity with conceptually related measures of psychiatric symptoms, quality of life, and perception of recovery. The findings support the utility of the IMRS as a measure of illness self-management and recovery in clients with schizophrenia and schizoaffective disorder. The general findings of this thesis support the IMR program to be effective in improving the ability of the participants to manage their disorder. The impact of neurocognitive dysfunction on the participants’ ability to learn the fundamentals of illness self-management seems to be limited, and symptom severity did not limit the benefits of the IMR program. Support for the utility of the IMRS to monitor the participants’ progress in the program was also found, providing a brief and economical method for assessing outcome of the IMR program.Syftet med föreliggande avhandlingsarbete var att undersöka Illness Management and Recovery (IMR) programmets effekter av att lära klienter att bättre hantera negativa konsekvenser av schizofreni eller schizoaffektiv sjukdom och att främja återhämtning. Detta åstadkoms genom en utvärdering av IMR programmets inverkan på psykosocial funktion och psykopatologi, en undersökning av specifik och generell påverkan av neurokognition avseende deltagarnas möjligheter att lära in grundläggande sjukdomshanteringsfärdigheter (illness self-management), samt en undersökning av huruvida schizofrenisymtomens svårighetsgrad inverkar på programutfallet. Vidare undersöktes Illness Management and Recovery Skalans (IMRS) användbarhet för att utvärdera sjukdomshantering och återhämtning (illness self-management and recovery) hos personer med schizofreni eller schizoaffektiv sjukdom. IMR programmets effekter utvärderades genom en randomiserad kontrollerad studie i vilken 41 programdeltagare jämfördes med deltagare i kontrollgrupp vilka fick enbart sedvanlig psykiatrisk behandling. Deltagarna rekryterades vid sex subspecialiserade psykiatriska öppenvårdsmottagningar och slumpades till att antingen delta i IMR programmet eller kontrollgrupp. IMR programmets deltagare uppvisade i jämförelse med kontrollgruppen förbättring i sjukdomshantering, minskade psykiatriska symtom, förbättrade coping-färdigheter samt minskade självmordsbeteenden. Resultaten stöder antagandet att IMR programmet är effektivt vad gäller att förbättra deltagarnas förmåga att hantera negativa effekter av schizofreni och schizoaffektiv sjukdom. Möjliga associationer mellan neurokognitiv funktion och förmågan att tillägna sig färdigheter för sjukdomshantering undersöktes hos 53 deltagare som genomförde IMR programmet. Resultaten pekar på att neurokognitiva svårigheter inte inverkar på deltagarnas möjligheter att lära sig sjukdomshantering enligt IMR modellen. Processhastighet var relaterad till klientrapporterad sjukdomshantering men inte till klinikerrapporterad sjukdomshantering. Processhastighet tycks vara relevant för klientens upplevelse av hur väl han eller hon tillägnat sig programmets strategier och färdigheter, snarare än sjukdomshantering per se. Huruvida schizofrenisymtomens svårighetsgrad inverkar på utfallet av IMR programmet undersöktes hos 52 deltagare som genomförde IMR programmet. Resultaten pekar på att signifikant fler deltagare uppfyllde svårighetsgradskriteriet för remission av schizofrenisymtom efter genomfört IMR program. Även deltagare som inte uppfyllde svårighetsgradskriteriet har nytta av IMR programmet något som indikeras av de båda gruppernas (uppfyllde jämfört med uppfyllde inte svårighetsgradskriteriet) likartade effektstorlekar. Illness Management and Recovery Skalans (IMRS) psykometriska egenskaper undersöktes för 107 deltagare med en schizofreni eller schizoaffektiv diagnos. Skalans enskilda frågor analyserades för att undersöka skalans användbarhet för att utvärdera deltagares progress och utfall i IMR programmet. Både klient och kliniker versionen av skalan uppvisade tillfredsställande intern konsistens, stor test-retest reliabilitet och konvergent validitet med konceptuellt relaterade instrument för psykiatriska symtom, livskvalité och återhämtning. Resultaten stöder antagandet att IMRS är ett användbart instrument för att utvärdera sjukdomskontroll och återhämtning för personer med schizofreni eller schizoaffektiv sjukdom. Avhandlingsarbetets resultat stöder antagandet att IMR programmet är effektivt vad gäller att förbättra deltagarnas förmåga att hantera de negativa konsekvenserna av schizofreni och schizoaffektiv sjukdom. Neurokognitiva svårigheter inverkar i begränsad utsträckning på deltagarnas möjligheter att lära sig sjukdomshantering och schizofrenisymtom tycks ha begränsad inverkan på programutfallet. Resultaten stöder även antagandet att IMRS är ett användbart instrument för att utvärdera sjukdomskontroll och återhämtning för personer med schizofreni eller schizoaffektiv sjukdom, vilket erbjuder en kortfattad och ekonomisk metod att utvärdera effekterna av IMR.
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Leporq, Benjamin. "Hépatopathies chroniques : méthodes de quantification en IRM à 1,5 T et 3,0 T pour le diagnostic et le suivi." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10279.
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La fibrose hépatique est la complication de toutes les hépatopathies chroniques et la cirrhose, correspondant à son stade évolué, est responsable d'une importante morbi-mortalité. En lien avec l'augmentation de l'incidence du diabète de type 2, des syndromes métaboliques et de l'obésité l'incidence de la stéatose hépatique non-alcoolique a considérablement augmentée au cours de ces 10 dernières années pour devenir la première cause d'hépatopathies chroniques dans les pays industrialisés. Face à une méthode de référence invasive pour le diagnostic et exposée à une importante variabilité inter et intra-observateur, aux erreurs d'échantillonnage ainsi qu'à un coût élevé, il existe un besoin clinique pour concevoir des méthodes non-invasives pour le diagnostic et le suivi des hépatopathies chroniques. Ainsi, l'objectif de ces travaux de thèse, était de proposer une méthodologie complète permettant la quantification de la graisse intra-hépatique et la quantification de la fibrose par IRM à 1,5 et 3,0 T. Pour la quantification de la fibrose, une méthode permettant la réalisation de cartographies des paramètres hémodynamiques hépatiques en imagerie de perfusion a été développée à 1,5 T. Ensuite, dans l'idée d'utiliser une approche multiparamétrique, nous avons optimisé un protocole permettant l'imagerie du mouvement incohérent intra-voxel (IVIM) sur le foie afin de l'associer à l'imagerie de perfusion à 3,0 T. Concernant la quantification de la graisse intra-hépatique, une méthode incluant une correction des effets des temps de relaxation par estimation séparée des valeurs de T1 et T2* des protons de l'eau et des lipides, une prise en compte des 5 composantes spectrales principales des lipides, ainsi qu'une procédure permettant la levée de l'ambigüité des composantes dominantes a été développée et évaluée à 1,5 et 3,0 T. Les paramètres hémodynamiques hépatiques quantifiés, en particulier le débit portal et l'index de perfusion hépatique, permettent d'établir la distinction entre l'absence de fibrose, une fibrose débutante, une fibrose avancée et une cirrhose. Pour la quantification de la graisse, la fraction volumique de graisse (FVG) donnée par notre méthode permet de quantifier de manière précise la quantité de graisse intra-hépatique en s'affranchissant des différents facteurs pouvant biaiser l’estimation. Par ailleurs, la FVG permet la distinction entre les différents stades histologiques de stéatose avec une excellente sensibilité/spécificité. L'association de l'imagerie de perfusion avec l'imagerie du mouvement incohérent intra-voxel est en cours d'évaluation à travers l'étude HEPATOMAP qui combine toute la méthodologie développée. Les résultats préliminaires de cette étude ont déjà permis de montrer que l'association entre l'IVIM et la méthode de quantification de la graisse permet de distinguer entre la stéatose pure et la stéato-hépatiteLiver fibrosis is the main complication of chronic liver diseases, and cirrhosis, corresponding to the end-stage of fibrosis, is an important cause of morbi-mortality. The incidence increase of diabetes, metabolism disorders and obesity involve an increase of NAFLD which became the first cause of chronic liver disease in western countries. Since liver biopsy is the gold standard for the diagnosis of chronic liver diseases, inherent risks, intra- and inter-observer variability associated to an important cost motivate a clinical need to develop non-invasive methods for chronic liver disease assessment. Thus, the aim of this PhD thesis was to develop a method allowing the quantification of fat liver content and liver fibrosis using MRI at 1.5 and 3.0 T. For liver fibrosis quantification a method allowing liver perfusion parameters mapping using a MR dynamic contrast enhanced method was developed at 1.5 T. Then, in order to use a multi-parametric approach, a protocol allowing intra-voxel incoherent motion imaging (IVIM) was optimized at 3.0T. The aim was to combine liver perfusion imaging and IVIM. Regarding liver fat content quantification, a method including a correction of relaxation time effects using a disjointed estimation of T1 and T2* relaxation times of fat and water, accounting for the NMR spectrum of fat and resolving the dominant component ambiguity problem was developed. Liver perfusion parameters, in particularly portal perfusion and hepatic perfusion index were found relevant to make the distinction between no fibrosis, non-advanced fibrosis, advanced fibrosis and cirrhosis. About liver fat content quantification, fat volume fraction (FVF) given by our method allowed to quantify liver fat content accurately without cofounding factor-related bias. Moreover, FVF allowed diagnosing histological grade of steatosis with an excellent sensitivity/specificity. Combination of liver perfusion imaging and IVIM is actually under evaluation through the HEPATOMAP study using all the methodology developed through this PhD thesis. Preliminary results of this study have shown that the combination of information acquired with both the fat quantification and IVIM methods could allow distinction between NAFLD and NASH
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Rossi, Alessandro. "Caratterizzazione di resine epossidiche per materiali compositi realizzati in infusione ad alta pressione." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016.
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I materiali compositi, grazie alla combinazione delle proprietà dei singoli componenti di cui sono costituiti, in particolare la coesistenza di elevate caratteristiche meccaniche e pesi ridotti, rivestono da tempo un ruolo fondamentale nell’industria aeronautica e nel settore delle competizioni automobilistiche e motociclistiche. La possibilità di progettare i materiali in funzione della loro applicazione, unita alla riduzione dei costi di produzione, permette una crescente diffusione del loro utilizzo e l’ampliamento delle applicazioni a moltissimi altri settori, sia per componenti di tipo strutturale, sia di tipo estetico. L’obiettivo della presente tesi è analizzare, attraverso una campagna sperimentale, il comportamento di diversi materiali realizzati con la tecnica di produzione HP-RTM, tramite prove di taglio interlaminare e flessione, al fine di verificare l’applicabilità di tale processo a prodotti strutturali, in modo da velocizzare i tempi di produzione e quindi di abbassare i costi, mantenendo al tempo stesso elevate proprietà meccaniche. Lo scopo di questa campagna quindi è fornire, attraverso lo studio di 30 serie di provini, il materiale migliore in termini di resistenza a flessione e taglio interlaminare; inoltre per ogni tipologia di materiale vengono descritte le diverse distribuzioni dei valori di rottura riscontrati, in modo da lasciare al progettista più libertà possibile nella scelta del materiale in base alle specifiche richieste per una determinata applicazione. Questo studio permette di analizzare l’influenza di ogni singolo componente (tipo di fibra, tipo di binder, presenza o assenza di IMR), all’interno della stessa resina.
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Dean, Timothy J. Physical Environmental & Mathematical Sciences Australian Defence Force Academy UNSW. "Development and evaluation of automated radar systems for monitoring and characterising echoes from insect targets." Awarded by:University of New South Wales - Australian Defence Force Academy. School of Physical, Environmental and Mathematical Sciences, 2007. http://handle.unsw.edu.au/1959.4/38667.
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This thesis describes the construction of a mobile Insect Monitoring Radars (IMR) and investigations of: the reliability of IMRs for observing insect migration in inland Australia; possible biases in IMR migration estimates; the relation between an insect???s size and its radar properties; radar discrimination between insect species; the effect of weather on the migrations of Australian plague locusts and of moths; the scale of these migrations; and here IMRs are best located. The principles of entomological radar design, and the main features of insect migration in inland Australia, are reviewed. The main procedures used in the study are: calculation of radar performance and of insect radar cross sections (RCSs); reanalysis of a laboratory RCS dataset; statistical analysis of a fouryear dataset of IMR and weather observations; and a field campaign using both two existing fixed IMRs and the new mobile unit. Statistical techniques used include correlation, multiple regression, discriminant analysis, and principal components analysis. The original results of this work include design details of the mobile IMR, extension of radar performance calculations to IMRs and evaluation of flight speed biases, a holistic approach to IMR design, the relation of insect RCS magnitudes and polarization patterns to morphological variables, an estimate of the accuracy of the retrieved parameters, evaluations of three approaches (oneparameter, theory-based, and a novel two-stage method) to target identification, and verification of inferred target identities using results from nearby light traps. Possible sites for future IMRs are identified. The major conclusions are that: a mobile IMR can be built with a performance equal to that of a fixed IMR but at half the cost; significant biases in the signal processing results arise from insect speed; locusts and moths can be distinguished if all RCS parameters are used; IMRs can be designed to match particular requirements; weather has a significant effect on insect migration, the best single predictor of insect numbers being temperature; moonlight has no effect; the spatial correlation of migration properties falls to 50% at a separation of 300 km; and migrating insects can be carried by the wind for 500 km in a single night
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Capelli, Laurent. "Etude des dimuons de la région des masses intermédiaires produits dans les collisions d'ions lourds auprès du SPS du CERN." Phd thesis, Université Claude Bernard - Lyon I, 2001. http://tel.archives-ouvertes.fr/tel-00000703.
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Dans cette thèse, nous étudions la production des dimuons dans une région de masse entre les résonances Phi et J/Psi (Région des Masses Intermédiaires, IMR) dans les collisions proton-noyau et noyau-noyau de haute énergie.L'expérience NA50, installée auprès de l'accélérateur SPS du CERN, détecte les paires de muons émises dans ces interactions au moyen d'un spectromètre spécifique. La mesure de la centralité des collisions repose sur trois détecteurs indépendants : un calorimètre électromagnétique, un détecteur de multiplicité et un calorimètre à zéro degré.
Les résultats des analyses proton-noyau fournissent une valeur de référence pour l'étude des interactions noyau-noyau. Les distributions expérimentales, corrigées de l'acceptance et de la résolution par une méthode quadri-dimensionnelle, des dimuons IMR sont correctement reproduites par la superposition des processus conventionnels DY et DDbar (désintégration des mésons charmés). L'extrapolation linéaire avec le nombre de masse des noyaux des résultats p-A aux collisions S-U et Pb-Pb, sous-estime systématiquement les spectres mesurés dans la région des masses intermédiaires.
Cet excès de dimuons IMR augmente avec la centralité des collisions. Plusieurs modèles théoriques sont présentés et comparés aux données noyau-noyau. Nous montrons qu'un modèle basé sur la diffusion des mésons D et Dbar dans l'état final ne reproduit pas les distributions expérimentales. Finalement, cette étude permet de proposer deux explications possibles de l'excès observé. Les spectres noyau-noyau peuvent être reproduits soit par une augmentation de la production de charme soit par la présence de dimuons thermiques émis par un milieu dense et chaud.
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Butscheidt, Sebastian Karl [Verfasser], and Marc [Akademischer Betreuer] Regier. "Einfluss des neuen iterativen Rekonstruktionsverfahrens „Iterative Model Reconstruction“ (IMR) auf die Abgrenzbarkeit normaler und pathologischer Lungenstrukturen in der Niedrigdosis- Thorax-CT im Vergleich zu iDose4TM und der herkömmlichen gefilterten Rückprojektion (FBP) / Sebastian Karl Butscheidt ; Betreuer: Marc Regier." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1121207154/34.
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Butscheidt, Sebastian Karl Verfasser], and Marc-Ulrich [Akademischer Betreuer] [Regier. "Einfluss des neuen iterativen Rekonstruktionsverfahrens „Iterative Model Reconstruction“ (IMR) auf die Abgrenzbarkeit normaler und pathologischer Lungenstrukturen in der Niedrigdosis- Thorax-CT im Vergleich zu iDose4TM und der herkömmlichen gefilterten Rückprojektion (FBP) / Sebastian Karl Butscheidt ; Betreuer: Marc Regier." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://nbn-resolving.de/urn:nbn:de:gbv:18-82296.
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Morton, Victoria Lyndsey. "Investigating the breadth of the transition state ensemble in Im7 and Im9." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434588.
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Le, Duff Cecile S. "Probing fold and function of immunity proteins Im7 and Im8 using NMR spectroscopy." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365164.
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Duarte, Daniel Fernandes. "Structural characterization of the urea-unfolded state of Colicin Immunity Protein Im7 and Im9." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10387.
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Dissertação para obtenção do Grau de Mestre em
Bioquímica Estrutural e FuncionalMost single domain proteins have the ability to fold spontaneously into a precise, functional three-dimensional structure in seconds or less. Understanding how this transition occurs will not only help to uncover the way in which an amino acid sequence encodes the corresponding structure but is also likely to provide insight into the folding/unfolding transitions that many proteins undergo as part of their normal functioning. The characterization of these states is particularly important because they often play crucial roles in folding and misfolding processes, responsible for many human neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. In this work, two well characterized proteins, Colicin immunity proteins Im7 and Im9, where used as model for a structural study involving two different approaches to promote their denaturation/unfolding. Im7 and Im9 share a high sequence and structural homology, but despite that fact they fold with different kinetic mechanism in vitro. By using 1H-15N HSQC spectra as a main tool, we have undertaken a comparative study to identify the residues more affected during the denaturation process of Im7 and Im9 promoted by a physical effect, temperature increase, and by a chemical agent, urea. Our aim was to detect possible similarities that could give insight into the aspects that govern folding/unfolding transitions. The results from the temperature study show that the residues most perturbed with increasing temperature are mostly located in loop regions between helices, while urea targets preferably residues that are accessible and solvent exposed. Our study, points out that the ends of well-structured helices can concertedly unfold without entering the mid region residues in the same unfolding process. There seems to be a correlation between dynamic residues (most affected by temperature) and the residues in the regions most perturbed by urea. The results shown that entire loop regions on both proteins may act as concerted units during the unfolding process, and contribute for favorable interactions that delimit and stabilize native-like structural features on the urea-unfolded state, allowing buried regions to be less solvent exposed.
Fundação para a Ciência e a Tecnologia - PEst-C/EQB/LA0006/2011 and Project no. PTDC/QUI-QUI/098892/2008
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Lemasson, Benjamin. "Evaluation de l'IRM multiparamétrique comme indicateur de l'effet de thérapies anti-angiogéniques sur des modèles de gliomes implantés chez le rat." Phd thesis, Université de Grenoble, 2010. http://tel.archives-ouvertes.fr/tel-00908915.
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L'IRM joue un rôle extrêmement important dans l'évaluation de nouvelles thérapies anti-tumorale vis-à-vis des gliomes tant en préclinique, qu'en clinique. L'objectif de cette thèse est de déterminer si un ou plusieurs paramètres IRM peuvent être utilisés comme indicateur d'effet thérapeutique sur des modèles de gliomes chez le rat. Nous avons évalué différents paramètres IRM (ADC : coefficient de diffusion apparent de l'eau, BVf : volume sanguin et VSI : index de taille des vaisseaux) sur 6 modèles de gliomes étudiés pour le même volume tumorale, puis au cours d'un suivi longitudinal de 2. Ces 2 études ont permis de valider ces paramètres IRM (robustesse des techniques, validation biologique). Dans une 3ème étude, nous avons suivi l'évolution de ces paramètres en y ajoutant la mesure de la perméabilité des vaisseaux à un agent de contraste, et ce lors du suivi de 2 thérapies (chimiothérapie et anti-angiogénique). Dans une dernière étude nous avons complété ce protocole par la perméabilité quantitative à deux agents de contraste de taille différente ainsi que la mesure de la saturation sanguine en oxygène (lSO2) lors du suivi de l'effet de 2 thérapies (anti-angiogénique et radiothérapie par rayonnement synchrotron) appliquées seules ou en combinaison sur un modèle de gliome. L'IRM multiparamétrique telle que présentée dans les différentes études, apparaît comme une modalité d'imagerie ayant un fort potentiel pour l'évaluation en préclinique de nouveaux médicaments sur les tumeurs cérébrales. Le transfert clinique des nouvelles techniques IRM utilisées durant cette thèse (VSI, perméabilité à 2 agents de contraste, lSO2) peut maintenant être envisagé dans un futur proche.
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Ježek, Jiří. "Open Source implementace IMS." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413075.
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The diploma thesis deals with open source implementations of IMS technology. The theoretical part describes the functioning of IMS and its architecture, including the protocols used, the process of registration and connection establishment, as well as potential security threats to IMS systems. Two open source IMS projects were selected, Open IMS Core and Project Clearwater, on which the work is focused. In its next part, the diploma thesis deals with the description of selected open source IMS projects, this part also includes a description of the implemented security of both projects and a detailed procedure of system installation with any necessary configuration. In its practical part, the diploma thesis focused on performance testing of selected projects using the Abacus 5000 hardware tester. First, initialization tests were performed, which verified the possibility of communication between the tester and the tested projects. Subsequently, it was possible to perform performance testing of selected projects. In performance testing, emphasis is placed on system stability, performance in the area of call set-up speed and response time of SIP messages and speed of user registration in the network, at different load levels. The systems have been tested for both call set-up and user registration. Part of the testing is also the implementation of the flood DoS inviteflood attack and the system's response to the increasing intensity of the attack. The last chapter is devoted to the comparison of selected IMS projects, where the test results are clearly presented. This chapter is partly based on publicly available information, such as the technical documentation of individual projects and possibly publicly available mailing lists. Part of the diploma thesis is also a laboratory task in which the student tries to work with Open IMS Core. The laboratory task focuses on the process of creating a user and his registration in the IMS network, establishing a call between individual users and internal routing in IMS networks. The task focuses mainly on signaling processes within the implemented tasks.
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Gerevich-Kopteff, Éva. "Madách Az ember tragédiája és finn fordításai a nemzeti recepció és a fordításelemzés tükrében /." Helsinki : [Suomalais-ugrilainen seura], 2003. http://catalogue.bnf.fr/ark:/12148/cb39215569q.
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Texte remanié de: Väitöskirja--Suomalais-ugrilainen laitos--Helsingin yliopisto, 2003.Condensé en anglais, résumé en finnois. Titre finnois de la Tragédie de l'Homme en haut de la couverture. Bibliogr.363-380.
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Kauther, Ralf. "Hegels Dialektik : ihr Anfang, ihre Methode, ihr Ziel /." Köln : R. Kauther, 1998. http://catalogue.bnf.fr/ark:/12148/cb39174227s.
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Kalaglarski, Boris Iv, and Geronimo Emilio Di. "IMS Interworking." Thesis, KTH, Kommunikationssystem, CoS, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-91992.
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The goal of this project was to analyze the IP Multimedia Subsystem (IMS) with respect to the interworking functionality between two or more IMS domains belonging to different operators. The thesis presents an overview of IMS, its purpose, the circumstances and the environment in which it has evolved, and a look into some of the challenges that lie ahead. Through careful examination of the history of the mobile communications and of IMS itself, the thesis attempts to give the reader a full and comprehendible understanding of what IMS is, what its purpose is, and why it came into existence. The thesis considers the different models of IMS interworking, as they are currently envisioned by the standardisation bodies and the telecom industry. This analysis aims to identify some of the problematic aspects of the IMS Interworking and to suggest concrete areas for further investigation, which will contribute to the future successful IMS development and deployment. The report looks into such aspects of IMS interworking as the DNS, different models for ENUM DNS resolution; security issues and technical challenges of security with respect to the network as a whole and some of the IMS network elements in particular, such as the DNS. This thesis also presents the findings of the authors, regarding the challenges of interworking between networks built to support different versions of the IP protocol. The thesis focuses on the areas of interest, mentioned above, as these have been identified as being of particular significance in connection with the further development of the IMS architecture.Målet med denna uppsats var att analysera IP Multimedia Subsystem (IMS) med fokus på samverkan mellan två eller flera IMS domäner som tillhör olika operatörer. Examensjobbet beskriver en övergripande bild av IMS, dess målsättning, förhållanderna och miljön som den har utvecklats i och några utav utmaningarna som ligger framöver. Uppsatsen försöker med hjälp av bakgrundsfakta om mobiltelefonins historia ge läsarna förståelse om vad IMS är, syftet med det och varför det existerar. Uppsatsen beskriver olika samverkningsmodeller av IMS som grundar sig i modeller från de olika standardiseringsorganen samt från telecomindustrin. Målet med denna analys är att identifiera några problemaspekter samt presentera konkreta områden att fortsätta arbeta på gällande IMS och dess gällande samverkan mellan olika operatörer. Detta kan bidra till fortsatt framgång med utvecklingen samt utspridningen av IMS. Uppsatsen tar upp samverkningsproblem med IMS så som DNS, olika uppslagsmetoder av ENUM DNS, säkerhetsfrågor och säkerhetstekniska utmaningar med fokus på nätverket samt några IMS nätverkselement som DNS:en. Uppsatsen lägger också fram författarnas slutsatser gällande samverkan av de olika nätverken med olika versioner av IP protokollet. Examensjobbet fokuserar på de olika områderna som är ovan nämnda, då de har blivit identiferade med speciell betydelse för att kunna fortsätta att framgångsrikt utveckla IMS arkitekturen.
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Matsushima, Luciana Cardoso. "Determinação das curvas de isodose e confirmação do planejamento em Radioterapia de Intensidade Modulada - IMRT convencional empregando as técnicas de termoluminescência, luminescência opticamente estimulada e detectores semicondutores." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-24042015-095037/.
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A radioterapia é uma das três principais modalidades utilizadas no tratamento de doenças malignas como o câncer; as outras duas são a quimioterapia e a radiocirurgia. Em contraste com outras especialidades médicas que necessitam principalmente do conhecimento clínico e da experiência de especialistas, a radioterapia, com a utilização da radiação ionizante no tratamento do câncer, depende do investimento pesado em tecnologias modernas e dos esforços colaborativos de diversos profissionais, cuja equipe coordenada influencia, sobremaneira, o resultado do tratamento. A Radioterapia de intensidade modulada (IMRT) com o uso de colimadores multilâminas (multileaf collimators MLCs) tem o potencial para alcançar um alto grau de conformidade da dose no alvo (tumor a ser tratado) e ainda promover a proteção de tecidos normais do que a maioria de outras técnicas de tratamento, especialmente para volumes-alvo ou órgãos de risco com formatos complexos. Entretanto, estudos recentes mostraram que baixas doses de radiação podem causar tumores secundários. Esse trabalho tem como objetivo a determinação da distribuição de dose de radiação absorvida em diversas simulações de tratamentos radioterápicos com o uso de dosímetros compostos de LiF:Mg,Ti; CaSO4:Dy e Al2O3:C, utilizando um objeto simulador de polimetilmetacrilato (PMMA) empregando as seguintes técnicas dosimétricas: termoluminescência (TL), luminescência opticamente estimulada (OSL) e detectores semicondutores (diodos).Radiotherapy is one of three principal treatment modalities used in the treatment of malignant diseases such as cancer; the other two are chemotherapy and radiosurgery. In contrast to other medical specialties that rely mainly on the clinical knowledge and experience of medical specialists, radiotherapy, with its use of ionizing radiation in treatment of cancer, relies heavily on modern technology and the collaborative efforts of several professionals whose coordinated team approach greatly influences the outcome of the treatment. Intensity modulated radiation therapy (IMRT) with the use of multileaf collimators (MLCs) has the potential to achieve a much higher degree of target conformity and normal tissue sparing than most other treatment techniques, especially for target volumes or organs at risk with complex shapes. However, recent studies show that low doses of radiation can cause secondary cancers. This work aims to determine the radiation dose distribution in several radiation therapy treatment simulations with use of LiF:Mg,Ti; CaSO4:Dy and Al2O3:C dosimeters using a PMMA phantom for the following dosimetry techniques: thermoluminescence, optically stimulated luminescence (OSL) and semiconductor detectors.
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Rönntorp, Catrin, and Marie Aronsson. "När det individuellt rationella blir kollektivt slöseri : Bör fstighetsbolagen i Karlstad införa individuell mätning av vatten och värme?" Thesis, Karlstad University, Karlstad University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-5929.
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Baechel, Nicholas J. "RELIEF AGENCY, HEGEMON, OR FAILURE? AN EVALUATION OF THE IMF AS CRISIS MANAGER." University of Akron / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1163097350.
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Krüger, Hartmut. "Frauen im Pietismus : ihr Dienst, ihre Verantwortung, ihr Einfluss." Marburg an der Lahn Francke, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2668119&prov=M&dokv̲ar=1&doke̲xt=htm.
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Bergöö, Martin. "IDR "Interaktionsdesignad rädsla"." Thesis, Malmö högskola, Institutionen för konst, kultur och kommunikation (K3), 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23137.
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This essay focuses on the possibilities and problems that come with having teleportation mixed with horror and fear and not having monsters in fear games. How it is to play a horror game without enemies and just being able as an Interactiondesigner to relay on the psychological feeling within the player, if the feeling is more than enough if the player him self get to fantasies and let their deepest fright feelings take over. Is there no difference if there are monsters/enemies or not. Is fright and fear already there before you encountering the enemies? These questions are answered as the paper also presents a game in the shape of a course that has been paralleled worked with. The world with the complete and finished game have bin done in the Hammer editor which the game HalfLife2 (VU games/Valve Software, 2004) is built on. The finished game is a result of several user tests from the prototype game and user questionnaires. Fear games are mainly built on humans’ psychological feelings, the imaginations and how one feel. Through strong usage and building upon these main factors to create fear I have worked from that perspective and investigated how I by best possible means, should do to create fear to fright players by not using enemies as main frightening objects. Focus has been on the narrative of both visual and auditive narration. I have also given an account of the advantage and disadvantages with working with the tool I have chosen, how it has affected my work and my result. The Result turned out to be even better than I had in mind and a positive attitude towards my game from all the test persons. They thought it was a good example that a horror game is not bound to have monsters in order to fright the player. I got a loot of good feedback, response and ideas of what I could improve and what was already good. Some wanted more light effects on the first part and others less sound in the last part. By listening to the test persons I started to create and shape the final version of the game. Everyone became scared and felt more or less frightened through all four parts of the game. I also got positive feedback on my theory from the test persons, that teleportation mixed with horror and fear is something that they could consider using more in games and that this was a good start in the right direction.
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Sartori, Viviane. "InHab-Read - IHR." reponame:Repositório Institucional da UFSC, 2017. https://repositorio.ufsc.br/xmlui/handle/123456789/180897.
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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia e Gestão do Conhecimento, Florianópolis, 2017.Made available in DSpace on 2017-11-14T03:21:56Z (GMT). No. of bitstreams: 1 348490.pdf: 9532825 bytes, checksum: bb189e301b30950fbc2c9049745f5d62 (MD5) Previous issue date: 2017
Os habitats de inovação são empreendimentos organizados sistematicamente para promover a inovação, propiciando a interação e a integração de diferentes atores. São fenômenos contemporâneos de grande relevância para o desenvolvimento de uma região ou de um país, pois operam com ativos de conhecimento. A implantação de um habitat de inovação implica, diretamente, no desenvolvimento socioeconômico e cultural da comunidade de seu entorno. Estes oferecem condições diferenciadas para desenvolver produtos e processos inovadores, com o propósito de fomentar as dinâmicas econômicas e sociais, locais e regionais, uma vez que tem a capacidade de reunir pessoas, tecnologias, recursos financeiros e conhecimento. A problemática levantada para esta pesquisa trata de como analisar as comunidades do entorno dos habitats de inovação em relação às suas necessidades, potencialidades e expectativas. O lastro teórico para esta tese está construído na intersecção entre os conceitos de habitats de inovação, parques tecnológicos, inovação, inovação social, tríplice e quádrupla hélice. O objetivo é elaborar uma metodologia para leitura e análise identificando, necessidades, potencialidades e expectativas das comunidades do entorno dos habitats de inovação. Esta pesquisa caracteriza-se como exploratória descritiva. Desenvolve-se a partir de uma revisão sistemática para levantar os conceitos básicos e um benchmarking para identificar práticas de leitura de entorno. Com estes elementos propõe-se uma metodologia de leitura de entorno desenvolvida em três fases: elaboração, prototipagem e aplicação. A elaboração constituiu-se em um instrumento online, que foi prototipada no entorno do Orion Parque, na cidade de Lages. A aplicação da metodologia para sua conformação foi feita no entorno do Sapiens Parque, em Florianópolis. Os atores envolvidos nesse processo foram gestores de 8 parques tecnológicos visitados, 10 gestores de organizações internas do Sapiens Parque, 201 gestores de organizações externas e 622 famílias situadas no entorno do Sapiens Parque. O resultado alcançado com este estudo foi a conformação de uma proposta metodológica adaptável para diferentes tipos de habitats de inovação, que possibilita realizar a leitura e a análisedo entorno desses empreendimentos, gerando informações que caracterizam o perfil da população local em relação às suas necessidades, potencialidades e expectativas. Com a aplicação da InHab-Read ? IHR ? Metodologia de leitura de entorno para habitats de inovação é possível orientar políticas e ações conjuntas entre a população do entorno e as organizações internas dos habitats, potencializando a interação entre todos os atores, e ampliando as dimensões dos processos de inovação tecnológica e econômica para a inovação social.
Abstract : Innovation habitats are systematically organized enterprises to promote innovation and provide the interaction and integration of different actors. They are contemporary phenomena of high relevance for the development of a region or a country because they operate with knowledge assets. The implementation of an innovation habitat directly implies the socioeconomic and cultural development of the surrounding community. These provide differentiated conditions for developing innovative processes and products to foster economic, social, local and regional dynamics as it can bring together people, technologies, financial resources, and knowledge. The issue regarding this research analyzes the communities surrounding the innovation habitats about their needs, potentialities, and expectations. The theoretical background for this thesis is built on the intersection between concepts of innovation habitats, technology parks, changes, social innovation, triple and quadruple propeller. The aim is to develop a methodology for reading and analysis, identifying needs, potentialities, and expectations of communities surrounding the innovation habitats. The study is characterized as descriptive and exploratory. It develops from a systematic review to obtain basic concepts and a benchmarking to identify surrounding reading practices. With such elements, it is proposed a methodology of environment interpretation developed in three phases: elaboration, prototyping, and application. The elaboration was constituted by an online instrument that was prototyped in the Orion Park?s surrounding, in the city of Lages. The methodology application for its configuration was developed in the Sapiens Park?s surrounding, in Florianópolis. The actors involved in the process were eight managers of the technological parks visited, ten managers of internal organizations of the Sapiens Parque, 201 managers of external companies and 622 families located around the Sapiens Parque. The result obtained with the study relates to an adaptive methodological proposal for different types of innovation habitats, which makes it possible to read and analyze the enterprises? surroundings, generating information that characterizes thelocal population profile regarding their needs, potentialities, and expectations. With the application of InHab-Read - IHR - Environment Reading Methodology for innovation habitats, it is possible to propose common policies and actions between the surrounding population and habits internal organizations, enhancing the interaction among all the actors, and broadening dimensions of technological and economic innovation processes for social change.
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Nagy, Ľuboš. "Tvorba IMS aplikací." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-218175.
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This thesis describes basic principles of IP Multimedia Subsystem, known as the IMS, and shows the possibility for design applications using IMS. Firstly, a generic architecture IMS as layer model divided into four logic layer with definition the interfaces and the main entities is described. The IMS is based on SIP and IP protocols. Then is the architecture of SIP with the main entities explained. Structure of packet, request and response method in the part of SIP is also described. After that, three network services, namely presence services, instant messaging services and push over cellular services are presented. For each services the figuration of their architecture and the basic definition of their main entities are shown. Moreover, the graphical diagrams of SIP signalization are depicted for these services. In the next chapter, the self implementation of services was designed, namely presence services and services for speech transmission with next secondary function as sending email with registration information of user. The project was designed as client - server application in the development studio SDS Ericsson 4.1. The client application was simulated as java application and also as an application for Symbian emulator. The process of client registration was performed with the help of ICP platform. Finally, the diagram of analysis communication client - server is displayed with the captured packets explanation by the help of network analyzer WireShark. The video files, which were specially created for this thesis showing presentations for presence services and sending email. The most important results are summarized in the end of this article.
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Kalström, Lovisa, and Elin Lindblad. "Energy Visualization out of the Developer's perspective : A qualitative study of Stockholm developers' willingness to pay." Thesis, KTH, Tillämpad termodynamik och kylteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-153777.
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Residential energy visualization has increased in popularity during the past years, due to both legislation and an increased focus on the environmental impact of buildings. Meanwhile, the European energy efficiency directive has raised a debate on legislation on individual metering and charging (IMC), in which many negative voices among property owners and developers are being raised. The controversies bring interesting aspects to the analysis of energy visualization and its prerequisite IMC. This thesis will analyze the possibilities and barriers to implement residential energy visualization in new buildings in Stockholm, and the focus will be on local developers' perspective. The purpose of the thesis is to establish Stockholm developers' willingness to pay (WTP) for an IMC and energy visualization solution. The thesis defines perceived utility as the driving force for WTP, and accordingly the developer WTP is analyzed by evaluation of the developers' perceived utility of different technical aspects of an energy visualization solution. The solution has been modularized into three modules; IMC of hot water, IMC of heating and residential visualization. The hypothesis is that utility of the solution modules is perceived differently depending on developer ownership and developer business model; if the developer builds for property management or to sell. The empirical data has been collected through twelve in-depth interviews with developers in Stockholm. The developers were of different size, ownership and with different business models. When looking at the developers from an overall perspective, the analysis shows that there is some willingness to pay for IMC of hot water but none for IMC of heating. It can also be seen that residential visualization is something that the developers have some interest in although the overall WTP is considered low. Although environmental and fairness aspects are often mentioned by the developers in the context of IMC and energy visualization, operational and financial utility seem to be more influential in driving willingness to pay and as these utilities are not perceived, the overall WTP is low or non-existent for IMC and energy visualization. The hypothesis that developers would perceive utility differently depending on ownership or business model, if they build for property management of for sales, could not be proven. There are possibly tendencies for such differences but in this study such patterns were not clear enough to state the hypothesis as true. Additional to the WTP and developer groups, insights and takeaways are presented. The insights and takeaways are based on opportunities and risks that developers perceive with IMC and visualization, as well as requirements they have on the systems.
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Flosi, Adriana Aparecida. "Desenvolvimento de cálculo de unidades monitoras para IMRT." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-03042012-092734/.
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A verificação de forma independente do cálculo de dose e de unidades monitoras num plano de tratamento de IMRT é um passo importante nos procedimentos de garantia de qualidade da técnica em questão. Atualmente este verificação é baseada apenas em medidas experimentais demoradas e trabalhosas. Neste trabalho foi desenvolvido uma metodologia de cálculo de unidades monitoras de forma independente como uma nova ferramenta para garantir a qualidade e exatidão dos tratamentos de IMRT. Os valores encontrados se aproximam bastante dos valores calculados pelo sistema de planejamento utilizado, de forma que o algoritmo de cálculo desenvolvido apresentou uma concordância dentro de ± 1,8 % para uma geometria simples. Após diversos testes e com os níveis de ação devidamente estabelecidos, a verificação independente da unidade monitora para planos de tratamento de IMRT se tornará uma ferramenta efetiva e eficiente no controle de qualidade que ajuda a identificar e reduzir possíveis erros de tratamento em radioterapia. Como contribuição original deste trabalho, assegura-se aos serviços de Radioterapia a utilização da metodologia desenvolvida como ferramenta de controle de qualidade em tratamentos com IMRT. Em especial aos serviços que não dispõem de recursos econômicos para adquirirem softwares comercialmente disponíveis para o cálculo independente da unidade monitora.Independent verification of dose calculations and monitor units settings of IMRT treatment plans is an important step in the quality assurance procedure for IMRT technique. At present, the verification is mainly based on experimental measurements, which are time consuming and laborious. In this work an independent methodology of monitor units calculation was developed as a new tool for IMRT treatments quality and precision assurance. The values found are near those calculated by the treatment planning system used, in a manner that the calculation algorithm demonstrated ± 1,8 % concordance in a simple geometry with the system. After several tests and the levels of action well established, the independent monitor units verification for IMRT treatment plans will become an effective and efficient tool in quality assurance, helping identification and the reduction of possible mistakes in radiotherapy treatments. To radiotherapy services is assured the use of the developed methodology as a tool of quality control in IMRT treatments as an original contribution of this work, specially those that do not dispose financial resources to acquire commercially available independent monitor unit calculus software.
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Sheta, Amal. "IMRT and Rotational IMRT (mARC) Using Flat and Unflat Photon Beams." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-208212.
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For more than 50 years
attening filters have been inserted into the beam path oflinacs to produce a uniform energy fluence distribution of the photon beam and make it suitable for clinical use. Recently, linacs without flattening fifilter (Flattening FilterFree - FFF) are increasingly used in radiotherapy because of its benefifits, e.g. high dose rate (2000 MU/min), reduced scattered and leakage radiation. Hypofractionated radiotherapy is interested in the high dose rate of FFF beams to shorten the treatment delivery time (TDT) especially the FFF beams have acceptable flatness at small fifieldsizes. Radiotherapy techniques that deliver intensity-modulated beams (IMBs), e.g.Tomotherapy, intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT), deal with the non-uniformity of the FFF beam profifile and produce homogeneous dose to the target as FF beams do. Siemens modified the Artiste linac in order to enable photon beam delivery with and without a flattening fifilter. The VMAT version developed by Siemens for Artiste linacs as a novel radiation technique is a modulated arc therapy (mARC). mARC technique is available with single, double and multiple complete or partial arcs.
The aims of the current study were the determination of the main characteristics of 7 MV and 11 MV FFF photon beams in comparison with their corresponding 6 MV and 10 MV FF photon beams from Artiste digital linacs. Furthermore, IMRT planning comparisons using FF and FFF photon beams were performed using an Oncentra planning system. The performance of various mARC techniques were estimated and compared with Step and Shoot (S&S) IMRT by using a RayStation planning system. The mARC plans created by FF and FFF beams were evaluated to know which technique is the best. All the treatment plans were created for simple and complex shaped target volumes. The treatment plans are compared using two parameters - plan quality and treatment effi ciency. In addition to the planning study, the plan quality assurance of IMRT and mARC plans were performed using two difffferent volumetric quality assurance devices, Delta4 and Octavius 4D.
Removal of the flattening fifilter causes changes in the dosimetric features of photon beams. IMRT plans with and without flattening fifilter were clinically acceptable where both plans have similar quality. In comparison with IMRT-FF, IMRT-FFF plansrequire more MUs and for some clinical cases require longer TDT. mARC technique can deliver dose distributions that are comparable to S&S-IMRT and could be an alternative with a potential to improve the effi ciency of the IMRT treatment delivery.
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Kuhlmann, Dörte. "Metamorphosen des Organizismus zur Formensprache der Lebendigen Architektur von Imre Makovecz /." [S.l. : s.n.], 1998. http://deposit.ddb.de/cgi-bin/dokserv?idn=970619812.
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Karpíšek, Filip. "Monitorování a účtování spojení v sítích IMS." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2015. http://www.nusl.cz/ntk/nusl-234960.
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This thesis describes protocols used in IP Multimedia Subsystem (IMS) networks. Freely available implementations of IMS system are described. The main goal is to describe design and implementation of a tool for analyzing communication between users and IMS system. The tool seeks and decodes signaling messages. These messages are analyzed for information about sessions which are necessary for session monitoring and accounting. Final gathered information are exported in a form of extended NetFlow/IPFIX records. We used open-source Open IMS Core implementation for building IMS network and creating test data. As endpoints we used another open-source application for Android OS called IMSDroid.
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Sanz, Teresa, and Maria Högberg. "Personalpolitiken inom IMO AB." Thesis, Södertörn University College, School of Business Studies, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-394.
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CUNHA, FERNANDO BRANDAO LOBATO. "ADAPTATION ALGORITHM OF IIR." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 1991. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=9838@1.
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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOA partir da forma geral do algoritmo de adaptação, é proposto o uso de mais uma variável de projeto, denominada janela. Esta janela tem por objetivo melhorar as características de convergência de algoritmos, cujos parâmetros são partes de estruturas IIR. A introdução das janelas é justificada heuristicamente e seu desempenho é avaliado por meio de diversas simulações de identificação de sistemas. Os resultados obtidos indicam aumentos significativos na velocidade de convergência (cerca de uma ordem de grandeza mais rápido do que os algoritmos atualmente mais usados), na precisão das estimativas dos parâmetros do problema e na robustez dos novos algoritmos (menor número de pólos instáveis durante a adaptação). Estes resultados foram observados em ambientes estacionários e não estacionários, com e sem ruído de medida e com ordem de identificação suficiente ou não.
From the adaptation algorithm general form it is proposed the usage of another design variable, called Window. The goal of this Window is to improve the convergence characteristics of algorithms whose parameters are parts of IIR Structures. The introduction of the Window is heuristically justified and its performance is eventuated by several system identification simulations. The results achieved suggest significant increase in the convergence speed (about one order of magnitude faster than the currently most used algorithms), in the parameter estimation precision and in the new algorithm robusteness (fewer unstable poles during adaptation). These results were observed in sationary and non-stationary environments, with and without measurement noise and with sufficient identification order or not.
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Shockley, Keith J. "Intelligent Maintenance Aid (IMA)." Thesis, Monterey, California. Naval Postgraduate School, 2006. http://hdl.handle.net/10945/2719.
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Technological complexities of current ground combat systems require advanced maintenance methods to keep the fleet in a state of operational readiness. Currently, maintenance personnel use paper Technical Manuals (TM) that are cumbersome and not easily transportable or updated in the field. This thesis proposes using the latest technology to support maintainers in the field or depot by integrating the TMs with the onboard diagnostics Built-In-Test (BIT) and Fault Isolation Test (FIT) of the vehicle, to provide the maintainer with an improved diagnostics tool to expedite troubleshooting analysis. This will be accomplished by connecting the vehicle, using the vehicle's 1553 multiplex bus, with the Graphical User Interface (GUI) of an Intelligent Maintenance Aid (IMA). The IMA will use Troubleshooting Procedure (TP) codes generated during BIT and FIT testing. Using the information provided by these TP codes, through the IMA GUI, information from the technical manuals will be displayed to aid the maintainers in their diagnostic work. The results of this thesis will serve as a baseline for further research and will be presented to the program management office for combat systems (PM-CS) for further consideration and development.US Army RDECOM-TACOM author (civilian).
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Sterk, Sabine. "Wunderheilmittel - und ihr Kommunikationsverhalten." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11612072.
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Neumann-Hartmann, Arlette. "Epinikien und ihr Aufführungsrahmen." Hildesheim Weidmann, 2007. http://d-nb.info/99416906X/04.
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Pierre, de Langtoft Thiolier Jean-Claude. "Le Règne d'Édouard Ier." Créteil : CÉLIMA [Centre d'études littéraires et iconographiques du Moyen âge], Université de Paris XII, 1989. http://catalogue.bnf.fr/ark:/12148/cb350356774.
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Texte remanié de: Th.--Histoire--Paris IV, 1978.Contient la trad. en vers français, due à Pierre de Langtoft, de la bulle adressée par Boniface VIII à Édouard Ier le 27 juin 1299, de la réponse des barons anglais réunis en Parlement à Lincoln (12 février 1301) et de celle d'Édouard Ier (17 mai 1301).
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Dohnálek, Václav. "Multimediální služby v IMS." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217854.
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This master thesis refers to a new technology in a mobil services IP multimedia subsystem. First, the theoreticl part, refers to the architectury of this technology and elementary protocols. Although it is real-time services, is nesessary to refer about the Quality of Services, that it ensures the condent transmition of data. The second, practisy part refers to a the development background SDS 4.0 FD1 from Ericsson ltd., that it is used develop aplications for IMS technology. It will be to develop the aplication , that it used to the IMS and it refers to the elementary function and comunication.
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Porubský, Tomáš. "Řešení bezpečnosti v IMS." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-218174.
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In the first part of my master's thesis the network architecture of IMS (IP Multimedia Subsystem) is presented. The database of subscribers HSS (Home Subscriber Server) and SLF (Subscription Locator Function), as well as a SIP CSCF servers (Call Session Control Functions) process a SIP signalization and an AS application server performing services, etc. I focus on the registration of subscribers in the IMS network with a list of transmitted messages and description of each interface that is used in this network. The most important interfaces, which I described here, are Gm, Mw, Cx, Dx and Sh. Then I focused on security in IMS problems, which are divided into categories of access security and network security. After that is the implementation of IMS network in an open source Open IMS Core System considered under the Linux operating system. Here is the problem description from the actual system installation, through the configuration of all necessary elements of the network to the communication party itself. The communication analysis in the initial registration process and in subsequent communications is described. Finally I created laboratory exercises with a focus on the Open IMS Core System, where students learn about architecture and principle of networks based on IMS technology operation, with individual elements necessary for the operation of the network and their configuration. Students also test simple captured traffic analysis.
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Amadori, Manuel. "Studio e sviluppo di applicazioni di "motion control" su piattaforma Siemens-Simotion D." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016.
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Questa tesi si propone di studiare il "motion control", come viene attualmente realizzato sulle macchine di IMA Life e come invece verrebbe realizzato con l'architettura proposta da Siemens. Vengono fatte le adeguate valutazioni sui due sistemi, per poi proporre un sistema di "motion control" innovativo applicabile sulle macchine IMA Life che sia in grado di aggiungere funzionalità a quello attuale.
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Rubin, Marcus, and Albin Rundqvist. "Administratör eller sjöbefäl? : En studie om befälens arbetssituation i dag." Thesis, Linnéuniversitetet, Sjöfartshögskolan, SJÖ, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-18885.
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Arbetet har svarat mot frågan om hur ett befäls arbetssituation ser ut i dag på bryggan och hur den mängd regler och riktlinjer som finns för vaktgående befäl påverkar hans förmåga att framföra fartyget på ett säkert sätt. För att studera detta har en litteraturstudie utförts där vi studerat transportstyrelsens utgivna haverirapporter samt forskning inom områdena om mänskliga faktorn, fartygsorganisation och sjösäkerhet. Det som framkommit under arbetets gång är att manskapet ombord de senaste åren allt mer har fått ge vika till förmån för teknik men då reglerna inte följt med i tempot kan det vara så att fartyg i dag inte uppfyller kraven för minimibesättning. Även om vi kan påvisa att befälen har en hög arbetsbelastning går det inte att se varför de handlat som de gjort vid olyckstillfällena. Vidare har konstaterats att det finns utrymme för framtida forskning i ämnet där man exempelvis kan se över hur haverirapporterna är utformade.This work answered the question about how the situation is today on the bridge for the nautical officers and how the amount of rules and guidelines that exists affects his ability to manoeuvre the ship in a safe way. To study this we have performed a literature study where we studied the Swedish Transport Agency’s published accident investigation reports as well as research in the fields of human error, shipping organization and safety at sea. Our findings show that the crew on board has been reduced due to technical advancement. However, the rules have not followed the same pace and therefore today’s ships may not fulfil the requirements of minimum manning on board. Although we can tell that the officers have an increased workload we cannot see why they have acted as they did at the time of the accidents. It can also be shown that there is a need for future research where, for example, studies on how the accident investigation reports are designed.
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Nena, Tomović. "Prilog istraživanju uticaja modela integrisanog sistema menadžmenta na performanse transportnih organizacija." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101379&source=NDLTD&language=en.
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Naučni cilj istraživanja u okviru doktorske disertacije je kompleksnog karaktera, koji se manifestuje:identifikacijom performansi transportne organizacije, koje se mogu smatrati značajnim za uspešno upravljanje organizacijom i prevođenje iz postojećeg u željeno stanjeidentifikacijom SMS, kojom su posmatrane transportne organizacije implementirale i koje su postale sastavni delovi menadžment sistema organizacijeistraživanjem načina na koje je moguće meriti uticaj primene SMS, odnosno IMS na performanse organizacije, sa ciljem da se istovremeno ukaže na slabosti i mogućnosti razvoja organizacije.Polazeći od formulisanih ciljeva, definisana je orginalna metodologija, postupak kojim se dokazuje opravdanost uspostavljenih osnovnih hipoteza disertacije, čija suština je da modeli integrisanih sistema menadžmenta imaju uticaja na performanse transportnih organizacija.Scientific aim of this research is complex and it is manifested by following: Identification of transport organization performances which can be considered as important for succesful organization management and shift from existing to favorable condition; Identification of SMS which transport organizations implemented and which became parts of organization management system; Research of ways on which is possible to measure effect of SMS application or IMS to organization performances with aim to emphasize defeciencies and possibilities for organization development.According to formulated aims, original methodology is defined. Is is practice which justifies main hypotheses of disertation. Their purpose is to make integrated management system models effective for performances of transport organizations.
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Borges, Leandro Federiche. "Validação da metodologia de controle da qualidade in vivo com auxílio de filme radiocrômico, aplicados à teleterapia." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17159/tde-04012017-155803/.
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A aferição da dose por técnica de dosimetria in vivo garante que a dose calculada pelo sistema de planejamento seja àquela entregue pelo acelerador linear (AL) durante a radioterapia, garantindo assim os processos de controle de qualidade. O objetivo deste trabalho foi validar a técnica de controle de qualidade em IMRT utilizando filme radiocrômico. Foram analisados 47 planejamentos de IMRT de três regiões: próstata, cabeça e pescoço e crânio. Para cada planejamento utilizouse um filme radiocrômico EBT2 acoplado ao cabeçote do acelerador linear através de uma bandeja preparada para o filme. A leitura e posterior análise da dose pontual e distribuição de dose após 24 horas, foi realizada em sofware desenvolvido em MatLab. O índice de aprovação foi de 92%. Quatro planos foram reprovados em pelo menos 1 critério, sendo 3 de cabeça e pescoço e 1 de crânio. Os resultados da dosimetria in vivo com filme radiocrômico foi validada, podendo ser considerada uma técnica confiável e prática na aferição da dose em radioterapia.The measurement of dose, using the in vivo technique dosimetry, ensures that the dose calculated by the planning system is exactly the same as the dose delivered in linear accelerator, this ensures quality assurance in radiotherapy. The objective of this study was to evaluate the quality control techinique of IMRT treatments using radiochromic film. We analyzed 47 IMRT plans, which divided into three regions: Prostate, head and neck, and skull. For each plan, we used a radiochromic film coupled in linear accelerator head by a tray prepared to film placement. The film was stored for 24 hours after irradiation. Reading and analysis of point dose and 2D dose distribution were performed after this period. ll plans analyzed, the approval rating was 92%, and the others were flunked at least one criterion. Based on the results obtained in vivo dosimetry with radiochromic film was validated. This technique is reliable and practical to measure the dose delivered by linear accelerator.
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Basetse, HR, G. Lecatsas, and JSJ Odendaal. "Rapid identification and typing of enterovirus isolates." Journal of Medical Technology SA, 2004. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000941.
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The use of the neutralisation assay in the serotyping of unknown enterovirus isolates has been successfully applied for years since
its description by Lim and Benyesh-Melnick1. However, the procedure is labour-intensive and time consuming. In addition, the continuous
depletion of the Benyesh-Melnick sera makes it prohibitive for most diagnostic laboratories to continue using the assay.
Owing to these factors, a majority of laboratories only type for the polioviruses and report any other enterovirus isolate as “a nonpolio
enterovirus”. With this approach, however, important findings such as the isolation of a new enterovirus or association of a
known enterovirus with a new clinical syndrome will remain unidentified.
In this study, a multiple-serum-pools approach similar to that described by Lim and Benyesh-Melnick1 (LBM) for the neutralisation
test, was applied in an immunofluorescence (IMF) test for the rapid serotyping of enteroviruses. This test was able to type any
unknown enterovirus isolate belonging to the different enterovirus serotypes tested in this study, in about three hours as compared to
the eight days currently taken by the LBM neutralisation test1.
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Reyes, Vidal Dylan, and Moreno José Juan Velasco. "Influencia de la parasitosis intestinal en el Índice de masa corporal y rendimiento escolar en alumnos de primero y segundo grado (Ciclo 2017-2018) de la primaria “Prof. Isaías Q. Domínguez”, Temoaya, México." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2019. http://hdl.handle.net/20.500.11799/104784.
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La parasitosis intestinal es de importancia para la salud pública por su alta prevalencia, su distribución prácticamente mundial y sus efectos.
La prevalencia mundial es de 270 millones de niños en edad prescolar y más de 600 millones en edad escolar que viven en zonas con intensa transmisión de parasitos. En México, la frecuencia de la enfermedad se encuentra entre las primeras 20 patologías en preescolares y escolares.
Estas afecciones por parásitos intestinales afectan el desarrollo físico y mental de los niños, aunado a las condiciones precarias de vivienda e higiene, se estima que el 18.9% de la población escolar se encuentra infectada por parásitos, muchos no son diagnosticados, reportados, ni estudiados, variando la estadística de forma considerable en diferentes zonas del país.
Por otro lado, las estadísticas nacionales de nutrición muestran, en el 2017 entre la edad de 5 a 9 años, una tasa por cada 100,000 habitantes de: 115.27 para desnutrición leve, 15.18 para moderada y 4.67 grave, 198.94 en obesidad, (no distingue grados). Por la edad, la secretaria de salud utiliza Índice masa corporal como principal método de evaluación y diagnóstico, motivo por el cual se utilizará en este trabajo. Esto no proporciona una evaluación completa, pero si rápida para iniciar con un diagnóstico y tratamiento oportuno. (6; 28)
Los estudios publicados que mencionan la relación entre parasitosis y desnutrición suelen ser significativa a nivel micronutriente, pero antropométricamente no se ha fijado una postura ya que la variabilidad de los factores de la población estudiada es mucha, aun así, los realizados en zona rural, en su mayoría, encuentran una relación. (7)
A su vez, los niños escolares pasan la mayor parte de su tiempo en labores escolares y, en México, las estadísticas mundiales de rendimiento académico son muy bajas, los factores que contribuyen a esto son múltiples, pero nos enfocaremos al estado de nutrición y el padecimiento de parásitos intestinales para comprobar si, por su prevalencia alta, puedan ser significativos. Solo existe un estudio donde no se encontró relación, en México, los estudios no relacionan las 3 variables, pero si existe la relación de desnutrición y bajo rendimiento escolar. (29; 30)
Este estudio se efectuó para dar a conocer como la incidencia de parasitosis en niños escolares está relacionada con la desnutrición que, a su vez, puede disminuir el rendimiento académico, afectando al niño respecto a su edad.
Esto pretende ser útil al sistema de salud, fortalecer la prevención, mejorar las medidas higienico-dieteticas y mejorar la capacidad de aprendizaje en escolares, lo que aumentaría el nivel académico.
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Garcia, Aaron Nicholas. "Comparative Investigation of Dosimetric Tools in IMRT." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1187369612.
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Miles, Danielle. "The Wanderers." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2280.
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My work focuses on moments that convey a wide range of human emotion. Through examination of these private moments, I investigate contemporary issues of isolation, alienation, and anguish. In my artwork, unrecognizable landscapes and unidentifiable solitary figures grace panoramic canvases devoid of color and fine detail yielding scenes that, while rooted in reality, lend themselves to the surreal. The compositions are designed to evoke feelings of unease, as the viewer is confronted with figures experiencing raw emotion.
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Darby, Heather. "Cycles of Nature." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2348.
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My work focuses on my physical connection to the earth. I translate what I see and visualize in nature into graphic shapes and patterns using textiles, fibers, and paints. Further, I interweave these materials through a variety of techniques, and I incorporate sewn lines to create compositions highlighting natural elements that depict the course of life. I employ a hands-on, low technology approach. This tactic contrasts my work as a professional graphic designer. While my professional efforts generally lack a physical connection with nature, due to digital simulations of real objects, my personal artwork allows me to step away from the insipid technology tools commonly used in today’s society.
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Haddock, Michelle. "Inductive Monitoring Systems: A CubeSat Ground-Based Prototype." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1515.
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Inductive Monitoring Systems (IMS) are the newest form of health monitoring available to the aerospace industry. IMS is a program that builds a knowledge base of nominal state vectors from a nominal data set using data mining techniques. The nominal knowledge base is then used to monitor new data vectors for off-nominal conditions within the system. IMS is designed to replace the current health monitoring process, referred to as model-based reasoning, by automating the process of classifying healthy states and anomaly detection. An IMS prototype was designed and implemented in MATLAB. A verification analysis then determined if the IMS program could connect to a CubeSat in a testing environment and could successfully monitor all sensors on board the CubeSat before in-flight use. This program consisted of two main algorithms, one for learning and one for monitoring. The learning algorithm creates the nominal knowledge bases and was developed using three data mining algorithms: the gap statistic method to find the optimal number of clusters, the K-means++ algorithm to initialize the centroids, and the K-means algorithm to partition the data vectors into the appropriate clusters. The monitoring algorithm employed the nearest neighbor searching algorithm to find the closest cluster and compared the new data vector with the closest cluster. The clusters found were used to establish the knowledge bases. Any data vector within the boundaries of the clusters was deemed nominal and any data vector outside the boundaries was deemed off-nominal. The learning and monitoring algorithms were then adapted to handle the data format used on a CubeSat and to monitor the data in real time. The developed algorithms were then integrated into a MATLAB GUI for ease of use. The learning and monitoring algorithms were verified with a 2-dimensional data set to ensure that they performed as expected. The final IMS CubeSat prototype was verified using 56-dimensional emulated data packages. Both verification methods confirmed that the IMS ground- based prototype was able to successfully identify all off-nominal conditions induced into the system.
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GRECCHI, ILARIA. "“Dietoterapia prescrittiva vs intervento educazionale di gruppo in soggetti sovrappeso/obesi al primo episodio di infarto del miocardio acuto: individuazione di nuovi marcatori periferici in prevenzione secondaria”." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1215977.
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La prevalenza dell’obesità sta crescendo in modo sostanziale sia nei Paesi sviluppati sia in quelli in via di sviluppo. Negli ultimi anni si è sviluppato un vasto consenso sul fatto che una perdita di peso corporeo del 10% sia in grado di ridurre significativamente le complicanze mediche (quali le patologie cardiovascolari) e i fattori di rischio associati all’eccesso ponderale. Tuttavia, la progressiva diffusione di sovrappeso e obesità e l’assenza di una strategia di trattamento efficace costituiscono un terreno fertile per il proliferare di differenti modelli interventistici. Ad oggi, il programma di intervento più diffuso rimane la “dietoterapia prescrittiva”. La terapia di gruppo (cognitivo-comportamentale) si è dimostrata negli ultimi anni più efficace nel trattamento dell’obesità rispetto all’intervento prescrittivo. Lo studio vuole valutare l'efficacia di un intervento educazionale di gruppo (trattamento B) in un campione di soggetti con diagnosi di sovrappeso e obesità (BMI > 24,9 kg/m2) che sono incorsi in un primo episodio di infarto miocardico acuto (sia STEMI sia NSTEMI), confrontato con l'approccio dietoterapico prescrittivo classico (trattamento A).
L’outcome primario dello studio è la riduzione del 5-10% del peso corporeo a 6-12 mesi dall’inizio del trattamento. Gli outcome secondari invece sono i seguenti: l’identificazione in prevenzione secondaria di nuovi biomarcatori periferici con significato prognostico-predittivo, da utilizzare in prevenzione primaria; l’identificazione di un marcatore periferico per il grasso epicardico che correli con lo spessore di EAT. Da Novembre 2013 a Settembre 2015 sono stati arruolati 90 pazienti. I pazienti che avevano dato il loro consenso scritto e che soddisfacevano le caratteristiche di inclusione sono stati randomizzati ad uno dei due trattamenti. Il trattamento educazionale di gruppo si è dimostrato essere più efficace della dietoterapia prescrittiva classica in termini di perdita di peso (in A, Δpeso T1-T6: -2,83%; in B, Δpeso T1-T6: -4,89%; in A, Δpeso T1-T12: +3,50%; in B, Δpeso T1-T12: -6,45%) e di miglioramento della composizione corporea sia nel breve che nel lungo termine. Tale intervento nutrizionale necessità tuttavia di essere perfezionato ulteriormente sulla base del costrutto della CBT, da adeguare alla condizione di cardiopatia ischemica. I risultati relativi allo spessore di EAT mostrano una riduzione dello stesso sia a sei che a 12 mesi per entrambi i trattamenti, con una percentuale di efficacia pressoché raddoppiata per i pazienti sottoposti ad intervento educazionale di gruppo (in A, ΔEAT-TS T1-T6: -5,00%; in B, ΔEAT-TS T1-T6: -18,84%; in A, ΔEAT-TS T1-T12: -11,67%; in B, ΔEAT-TS T1-T6: -30,43%), suggerendo la necessità di approfondire il ruolo del grasso epicardico nell’insorgenza della cardiomiopatia ischemica e del suo potenziale diagnostico e prognostico-predittivo utile in prevenzione primaria. Inoltre, la Serglicina si è dimostrata essere un buon marcatore di correlazione con lo spessore del grasso epicardico (p value T6 = 0,023; p value T12 = 0,002; p value andamento temporale = 0,003), da proporre eventualmente nella routine diagnostica con significato prognostico/predittivo di rischio cardiovascolare obesità viscerale-correlato. I dati ottenuti in merito ai livelli di espressione plasmatica di Chemerina e Greline suggeriscono altresì un ruolo attivo di queste molecole nei processi pro-infiammatori e cardiorigenerativi, rispettivamente. Sarebbe pertanto interessante approfondire il grado di correlazione esistente tra Chemerina e danno tissutale, nonché tra le Greline e il loro potere cardiorigenerativo, al fine di inserire i loro dosaggi nella pratica clinica con significato prognostico/predittivo di rischio cardiovascolare.