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Journal articles on the topic 'IMRT'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Youssef, Irini, Jennifer Yoon, Nader Mohamed, et al. "Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Oropharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy." JAMA Network Open 5, no. 11 (2022): e2241538. http://dx.doi.org/10.1001/jamanetworkopen.2022.41538.

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ImportancePatients with oropharyngeal carcinoma (OPC) treated with radiotherapy often experience substantial toxic effects, even with modern techniques such as intensity-modulated radiation therapy (IMRT). Intensity-modulated proton therapy (IMPT) has a potential advantage over IMRT due to reduced dose to the surrounding organs at risk; however, data are scarce given the limited availability and use of IMPT.ObjectiveTo compare toxic effects and oncologic outcomes among patients with newly diagnosed nonmetastatic OPC treated with IMPT vs IMRT with or without chemotherapy.Design, Setting, and Pa

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Thaker, Nikhil G., David Boyce-Fappiano, Matthew S. Ning, et al. "Activity-Based Costing of Intensity-Modulated Proton versus Photon Therapy for Oropharyngeal Cancer." International Journal of Particle Therapy 8, no. 1 (2021): 374–82. http://dx.doi.org/10.14338/ijpt-20-00042.1.

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Abstract Purpose In value-based health care delivery, radiation oncologists need to compare empiric costs of care delivery with advanced technologies, such as intensity-modulated proton therapy (IMPT) and intensity-modulated radiation therapy (IMRT). We used time-driven activity-based costing (TDABC) to compare the costs of delivering IMPT and IMRT in a case-matched pilot study of patients with newly diagnosed oropharyngeal (OPC) cancer. Materials and Methods We used clinicopathologic factors to match 25 patients with OPC who received IMPT in 2011-12 with 25 patients with OPC treated with IMRT

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Yoon, Han Gyul, Yong Chan Ahn, Dongryul Oh, et al. "Early Clinical Outcomes of Intensity Modulated Radiation Therapy/Intensity Modulated Proton Therapy Combination in Comparison with Intensity Modulated Radiation Therapy Alone in Oropharynx Cancer Patients." Cancers 13, no. 7 (2021): 1549. http://dx.doi.org/10.3390/cancers13071549.

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Purpose: To report the early clinical outcomes of combining intensity-modulated radiation therapy (IMRT) and intensity-modulated proton therapy (IMPT) in comparison with IMRT alone in treating oropharynx cancer (OPC) patients. Materials and Methods: The medical records of 148 OPC patients who underwent definitive radiotherapy (RT) with concurrent systemic therapy, from January 2016 till December 2019 at Samsung Medical Center, were retrospectively reviewed. During the 5.5 weeks’ RT course, the initial 16 (or 18) fractions were delivered by IMRT in all patients, and the subsequent 12 (or 10) fr

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Nenoff, Lena, Atchar Sudhyadhom, Jackson Lau, Gregory C. Sharp, Harald Paganetti, and Jennifer Pursley. "Comparing Predicted Toxicities between Hypofractionated Proton and Photon Radiotherapy of Liver Cancer Patients with Different Adaptive Schemes." Cancers 15, no. 18 (2023): 4592. http://dx.doi.org/10.3390/cancers15184592.

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With the availability of MRI linacs, online adaptive intensity modulated radiotherapy (IMRT) has become a treatment option for liver cancer patients, often combined with hypofractionation. Intensity modulated proton therapy (IMPT) has the potential to reduce the dose to healthy tissue, but it is particularly sensitive to changes in the beam path and might therefore benefit from online adaptation. This study compares the normal tissue complication probabilities (NTCPs) for liver and duodenal toxicity for adaptive and non-adaptive IMRT and IMPT treatments of liver cancer patients. Adaptive and n

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Cunningham, Lisa, Scott Penfold, Eileen Giles, Hien Le, and Michala Short. "Impact of Breast Size on Dosimetric Indices in Proton Versus X-ray Radiotherapy for Breast Cancer." Journal of Personalized Medicine 11, no. 4 (2021): 282. http://dx.doi.org/10.3390/jpm11040282.

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Deep inspiration breath hold (DIBH) radiotherapy is a technique used to manage early stage left-sided breast cancer. This study compared dosimetric indices of patient-specific X-ray versus proton therapy DIBH plans to explore differences in target coverage, radiation doses to organs at risk, and the impact of breast size. Radiotherapy plans of sixteen breast cancer patients previously treated with DIBH radiotherapy were re-planned with hybrid inverse-planned intensity modulated X-ray radiotherapy (h-IMRT) and intensity modulated proton therapy (IMPT). The total prescribed dose was 40.05 Gy in

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Gergelis, Kimberly R., Miao Bai, Jiasen Ma, et al. "Long-Term Patient-Reported Bowel and Urinary Quality of Life in Patients Treated with Intensity-Modulated Radiotherapy Versus Intensity-Modulated Proton Therapy for Localized Prostate Cancer." Current Oncology 32, no. 4 (2025): 212. https://doi.org/10.3390/curroncol32040212.

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Purpose: This study aimed to compare long-term patient-reported outcomes in bowel and urinary domains between intensity-modulated radiotherapy (IMRT) and intensity-modulated proton therapy (IMPT) for localized prostate cancer. Methods and Materials: Patients with clinical T1–T2 prostate cancer receiving IMRT or IMPT at a tertiary cancer center from 2015–2018 were analyzed to determine the changes in the prospectively collected bowel function (BF), urinary irritative/obstructive symptoms (UO), and urinary incontinence (UI) domains of EPIC-26. The mean changes in EPIC-26 scores were evaluated fr

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Lescut, Nicolas, Etienne Martin, Philippe Maingon, et al. "Dependence of intrafraction prostate motion within the pelvis on fraction duration during whole pelvic intensity modulated arctherapy (IMAT) versus dynamic IMRT." Journal of Clinical Oncology 31, no. 6_suppl (2013): 190. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.190.

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190 Background: To compare the 3-dimensional intra-fraction variations of prostate position within the pelvis with whole-pelvic fixed-field intensity-modulated radiation therapy (IMRT) vs. intensity-modulated arc therapy (IMAT) in high-risk prostate cancer. Methods: Fifteen PCa patients underwent whole pelvic radiotherapy using either dynamic IMRT with a sliding window technique (n= 8) or IMAT (n= 7). All the patients had a kV cone-beam computed tomography (CBCT) before and immediately after each fraction of IMRT or IMAT. Intra-fraction motions of the prostate were determined using a 2-step pr

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Jain, Varsha, Peyton Irmen, Shannon O'Reilly, Jennifer H. Vogel, Liyong Lin, and Alexander Lin. "Predicted Secondary Malignancies following Proton versus Photon Radiation for Oropharyngeal Cancers." International Journal of Particle Therapy 6, no. 4 (2020): 1–10. http://dx.doi.org/10.14338/ijpt-19-00076.1.

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Abstract Purpose There has been a recent epidemic of human papillomavirus (HPV)–positive oropharyngeal cancer, accounting for 70% to 80% of diagnosed cases. These patients have an overall favorable prognosis and are typically treated with a combination of surgery, chemotherapy, and radiation. Because these patients live longer, they are at risk of secondary malignant neoplasms (SMNs) associated with radiation therapy. Therefore, we assessed the predicted risk of SMNs after adjuvant radiation therapy with intensity-modulated proton therapy (IMPT) compared with intensity modulated photon radiati

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Patrice Aka, Fleman, Roger Taylor, Richard Hugtenburg, Jamil Lambert, and James Powell. "Hippocampal sparing radiotherapy in adults with primary brain tumours: a comparative planning and dosimetric study using IMPT, IMRT and 3DCRT." Neuro-Oncology 21, Supplement_4 (2019): iv2—iv3. http://dx.doi.org/10.1093/neuonc/noz167.008.

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Abstract Introduction We assessed the feasibility of hippocampal sparing in adults with primary brain tumours using Intensity Modulated Proton Therapy (IMPT) and compared this with Intensity Modulated Radiotherapy (IMRT) and 3D-Conformal Radiotherapy (3DCRT). Methods and Materials 20 patients were identified, and each patient underwent a radiotherapy planning CT scan and 2 MRI scans. A pre-operative diagnostic MRI scan was fused with the planning CT and used for target delineation and a dedicated 3T MRI scan at the time of planning was fused with the CT for hippocampus delineation. 3 hippocamp

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Wong, Ru Xin, Jacqueline Faught, Melissa Gargone, et al. "Cardiac-Sparing and Breast-Sparing Whole Lung Irradiation Using Intensity-Modulated Proton Therapy." International Journal of Particle Therapy 7, no. 4 (2021): 65–73. http://dx.doi.org/10.14338/ijpt-20-00079.1.

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Abstract Purpose Whole lung irradiation (WLI) is indicated for certain pediatric patients with lung metastases. This study investigated whether WLI delivered as intensity-modulated proton therapy (IMPT) could significantly spare the heart and breasts when compared with conventional WLI delivered with anteroposterior/posteroanterior photon fields and with intensity-modulated photon therapy (IMRT) WLI. Materials and Methods Conventional, IMRT, and IMPT plans were generated for 5 patients (aged 5-22 years). The prescription dose was 16.5 GyRBE in 1.5-GyRBE fractions. Conventional plans used 6-MV

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Vernanda, V., A. Azzi, and S. A. Pawiro. "Dose Planning Evaluation of Intensity-Modulated Proton Therapy (IMPT) Technique Based on In-House Dynamic Thorax Phantom." Atom Indonesia 1, no. 1 (2023): 7–11. http://dx.doi.org/10.55981/aij.2023.1196.

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One of the drawbacks of the Intensity Modulated Radiation Therapy (IMRT) technique is that the absorbed dose in healthy tissue is relatively high. Proton beam has characteristics that can compensate for these drawbacks. The Bragg peak characteristic of a proton beam allows the administration of high radiation doses to the target organ only. Non-Small Cell Lung Cancer (NSCLC) cases are located in the vicinity of many vital organs, so radiation doses that exceed a certain limit will have a significant impact on these organs. Proton is a heavy particle that exhibits interaction patterns with tiss

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Park, Seung Gyu, Yong Chan Ahn, Dongryul Oh, et al. "Salivary Gland Volume Changes and Dry Mouth Symptom Following Definitive Radiation Therapy in Oropharyngeal Cancer Patients—A Comparison of Two Different Approaches: Intensity-Modulated Radiation Therapy Versus Intensity-Modulated Radiation Therapy/Intensity-Modulated Proton Therapy Combination." Cancers 17, no. 3 (2025): 554. https://doi.org/10.3390/cancers17030554.

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Abstract: Background/Objectives: We aimed to compare the salivary gland volume changes following intensity-modulated radiation therapy (IMRT) alone versus IMRT/intensity-modulated proton therapy (IMPT) combination in oropharyngeal cancer (OPC). Methods: We retrospectively reviewed 78 OPC patients who underwent definitive RT with ipsilateral neck irradiation. RT techniques were either IMRT alone or IMRT/IMPT combination. Salivary gland volumes over time in relation to dry mouth symptom were evaluated. Results: Patients’ characteristics were well balanced between groups. The mean dose to the ips

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Gogineni, Emile, Hao Chen, Alexandra C. Istl, Fabian M. Johnston, Amol Narang, and Curtiland Deville. "Comparative In Silico Analysis of Ultra-Hypofractionated Intensity-Modulated Photon Radiotherapy (IMRT) Versus Intensity-Modulated Proton Therapy (IMPT) in the Pre-Operative Treatment of Retroperitoneal Sarcoma." Cancers 15, no. 13 (2023): 3482. http://dx.doi.org/10.3390/cancers15133482.

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Background: While pre-operative radiation did not improve abdominal recurrence-free survival for retroperitoneal sarcoma (RPS) in the randomized STRASS trial, it did reduce rates of local recurrence. However, the risk of toxicity was substantial and the time to surgery was prolonged. A combination of hypofractionation and proton therapy may reduce delays from the initiation of radiation to surgery and limit the dose to surrounding organs at risk (OARs). We conducted a dosimetric comparison of the pre-operative ultra-hypofractionated intensity-modulated photon (IMRT) and proton radiotherapy (IM

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Smith, Grace L., Shuangshuang Fu, Matthew S. Ning, et al. "Work Outcomes after Intensity-Modulated Proton Therapy (IMPT) versus Intensity-Modulated Photon Therapy (IMRT) for Oropharyngeal Cancer." International Journal of Particle Therapy 8, no. 1 (2021): 319–27. http://dx.doi.org/10.14338/ijpt-20-00067.1.

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Abstract Purpose We compared work outcomes in patients with oropharyngeal cancer (OPC), randomized to intensity-modulated proton (IMPT) versus intensity-modulated photon therapy (IMRT) for chemoradiation therapy (CRT). Patients and Methods In 147 patients with stage II-IVB squamous cell OPC participating in patient-reported outcomes assessments, a prespecified secondary aim of a randomized phase II/III trial of IMPT (n = 69) versus IMRT (n = 78), we compared absenteeism, presenteeism (i.e., the extent to which an employee is not fully functional at work), and work productivity losses. We used

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Lin, Ruihe, Jie Shan, Taize Yuan, and Chaonan Qian. "Dosimetric comparison of intensity-modulated proton radiotherapy versus intensity-modulated photon-based radiotherapy for breast cancer." Visualized Cancer Medicine 2 (2021): 5. http://dx.doi.org/10.1051/vcm/2021002.

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Purpose: This study aims to compare the dosimetric differences in intensity-modulated proton therapy (IMPT) using pencil beam scanning technology and intensity-modulated photon-based radiotherapy (IMRT) in hypofractionated whole-breast irradiation (HF-WBI) and find out the more beneficial technique. Methods and Materials: Eight breast cancer (BC) patients with pathological stage T1 ~ 2N0M0 were immobilized and underwent 4D-CT scanning used deep inspiration breath-hold (DIBH) technology. The IMPT and IMRT plans were designed for each patient. The IMPT plans used two en-face beam angles. IMRT pl

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Frank, Steven J., Paul Busse, David Ira Rosenthal, et al. "Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for the treatment of head and neck oropharyngeal carcinoma (OPC)." Journal of Clinical Oncology 42, no. 16_suppl (2024): 6006. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.6006.

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6006 Background: IMPT has unique biologic and physical properties compared with IMRT, limits radiation dose beyond the targeted tumor volumes, and is a novel de-intensification strategy for the management of head and neck tumors. This study was designed to compare the outcomes for patients with OPC after chemoradiation therapy (CRT) with IMRT vs IMPT. Methods: This is a multi-center, randomized, phase III non-inferiority OPC trial Stage III/IV (AJCC 7th) squamous cell carcinoma stratified patients by human papillomavirus status, smoking status, and receipt of induction chemotherapy (IC). The p

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Corbeau, Anouk, Remi A. Nout, Jan Willem M. Mens, et al. "PROTECT: Prospective Phase-II-Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System." Cancers 13, no. 20 (2021): 5179. http://dx.doi.org/10.3390/cancers13205179.

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External beam radiation therapy (EBRT) with concurrent chemotherapy followed by brachytherapy is a very effective treatment for locally advanced cervical cancer (LACC). However, treatment-related toxicity is common and reduces the patient’s quality of life (QoL) and ability to complete treatment or undergo adjuvant therapies. Intensity modulated proton therapy (IMPT) enables a significant dose reduction in organs at risk (OAR), when compared to that of standard intensity-modulated radiation therapy (IMRT) or volumetric-modulated arc therapy (VMAT). However, clinical studies evaluating whether

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Wilkens, J. "THE IMRT/IMPT OPTIMIZATION PROBLEM." Radiotherapy and Oncology 92 (August 2009): S10. http://dx.doi.org/10.1016/s0167-8140(12)72609-9.

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Nguyen, Tu Thi Cam, Nhon Van Mai, and Binh Thai Nguyen. "Comparison of intensity modulated photon therapy and intensity modulated proton therapy plans for prostate cancer." Science and Technology Development Journal 18, no. 3 (2015): 93–100. http://dx.doi.org/10.32508/stdj.v18i3.825.

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Nowadays, traditional radiation therapy using x-rays is still the most common type of external exposure in curing cancer. However, the persisting problem is that significant dose delivered to normal tissues because of the characteristics of interaction of photons with matter even with the most advanced delivery techniques such as IMRT, IGRT, etc. Proton therapy is not only the technique producing better conformity to target but also better sparing to organs at risk. In this work, intensity modulated proton therapy (IMPT) and intensity modulated photon therapy (IMRT) plans are generated for a p

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De Felice, Francesca, Alessandro Vai, Anna Maria Camarda, Nicola Alessandro Iacovelli, and Ester Orlandi. "Lower-Neck Sparing Using Proton Therapy in Patients with Uninvolved Neck Nasopharyngeal Carcinoma: Is It Safe?" Journal of Clinical Medicine 11, no. 12 (2022): 3297. http://dx.doi.org/10.3390/jcm11123297.

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Undifferentiated carcinoma of the nasopharynx (NPC) is a rare disease, which usually occurs in the Asian population. Due to its anatomic location, it is characterised by rich lymph node drainage and has a high incidence of cervical node metastasis. However, cervical nodal metastasis commonly involves retropharyngeal nodes and level II nodes, followed by level III nodes. In recent years, innovations in terms of systemic treatments and radiotherapy techniques have improved oncological outcome and treatment-related toxicities. Therefore, there is a growing interest in de-intensification strategie

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Taparra, Kekoa, Scott C. Lester, W. Scott Harmsen, et al. "Reducing Heart Dose with Protons and Cardiac Substructure Sparing for Mediastinal Lymphoma Treatment." International Journal of Particle Therapy 7, no. 1 (2020): 1–12. http://dx.doi.org/10.14338/ijpt-20-00010.1.

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Abstract Purpose Electrocardiogram-gated computed tomography with coronary angiography can be used for cardiac substructure sparing (CSS) optimization, which identifies and improves avoidance of cardiac substructures when treating with intensity modulated radiotherapy (IMRT). We investigated whether intensity modulated proton therapy (IMPT) would further reduce dose to cardiac substructures for patients with mediastinal lymphoma. Patients and Methods Twenty-one patients with mediastinal lymphoma were enrolled and underwent electrocardiogram-gated computed tomography angiography during or short

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Agazaryan, Nzhde, Wolfgang Ullrich, Steve P. Lee, and Timothy D. Solberg. "A methodology for verification of radiotherapy dose calculation." Journal of Neurosurgery 101, Supplement3 (2004): 356–61. http://dx.doi.org/10.3171/sup.2004.101.supplement3.0356.

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Object. A methodology for dosimetric verification of radiation therapy plans was developed and implemented. Dosimetric accuracy of clinically active intensity-modulated radiotherapy (IMRT) and intensity-modulated radiosurgery (IMRS) programs was assessed using this methodology. Methods. The methodology included several dosimetric tasks that were performed to assess the dosimetric accuracy of a treatment plan. Absolute dosimetry of the composite plan was performed using an ionization chamber. Film dosimetry was performed for each individual field and for the multifield composite plan. Calculate

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Oelfke, U., and T. Bortfeld. "Optimization of Physical Dose Distributions with Hadron Beams: Comparing Photon IMRT with IMPT." Technology in Cancer Research & Treatment 2, no. 5 (2003): 401–12. http://dx.doi.org/10.1177/153303460300200505.

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Intensity modulated radiotherapy with high enengy photons (IMRT) and with charged particles (IMPT) refer to the most advanced development in conformal radiation therapy. Their general aim is to increase local tumor control rates while keeping the radiation induced complications below desired thresholds. IMRT is currently widely introduced in clinical practice. However, the more complicated IMPT is still under development. Especially, spot-scanning techniques integrated in rotating gantries that can deliver proton or light ion-beams to a radiation target from any direction will be available in

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Dell’Oro, Mikaela, Michala Short, Puthenparampil Wilson, et al. "Influence of Target Location, Size, and Patient Age on Normal Tissue Sparing- Proton and Photon Therapy in Paediatric Brain Tumour Patient-Specific Approach." Cancers 12, no. 9 (2020): 2578. http://dx.doi.org/10.3390/cancers12092578.

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Background: Proton radiotherapy produces superior dose distributions compared to photon radiotherapy, reducing side effects. Differences between the two modalities are not fully quantified in paediatric patients for various intracranial tumour sites or age. Understanding these differences may help clinicians estimate the benefit and improve referral across available centres. Our aim was to compare intensity-modulated proton therapy (IMPT) and intensity-modulated photon radiotherapy (IMRT) radiation doses for select paediatric intracranial tumours. Methods: IMPT and IMRT dose distributions for

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Allen, Aaron M., Luciant Wolfsberger, Roy B. Tishler, and Laurence E. Court. "Options for Combining Altered Fractionation with IMRT." Technology in Cancer Research & Treatment 7, no. 6 (2008): 457–61. http://dx.doi.org/10.1177/153303460800700607.

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We set out to investigate IMRT-based concomitant boost. Eight patients with stage III/IV squamous cell carcinoma of the head and neck treated with once daily with chemoradiotherapy at the Dana-Farber/Brigham and Women's Hospital had their treatment plans reviewed with IRB approval. Each case was replanned for treatment with a a concomitant boost regimen. Plans delivered 1.9 Gy in 30 fractions to 57 Gy with a boost of 1.5 Gy in 10 fractions for a total dose of 72 Gy. The boost was planned with both IMRT and 3-D conformal, to compare the two techniques. For each patient, both plans (IMRT-IMRT an

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Vydia, Gautam Vedagiri, Arulpandiyan Ranganathan, Ramanaiah Kaluvoya, et al. "A Dosimetric Evaluation of Thyroid Sparing and Thyroid Optimised Radiotherapy in Locally Advanced Head and Neck Cancer." Asian Pacific Journal of Cancer Care 10, no. 1 (2025): 3–6. https://doi.org/10.31557/apjcc.2025.10.1.3-6.

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Background: Radiation-induced hypothyroidism is a frequent complication of radiotherapy for head and neck cancers due to the thyroid’s proximity to treatment areas. Advances in radiation therapy, such as Intensity Modulated Radiation Therapy (IMRT), have made it possible to reduce radiation exposure to the thyroid while maintaining effective tumor coverage. This study evaluates the dosimetric outcomes of thyroid-optimized (TO-IMRT) and thyroid-sparing (TS-IMRT) techniques in reducing thyroid radiation dose without compromising treatment efficacy. Methods: A retrospective analysis was conducted

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Ahmad, Irfan, Kundan Singh Chufal, Chandi Prasad Bhatt, et al. "Plan quality assessment of modern radiotherapy delivery techniques in left-sided breast cancer: an analysis stratified by target delineation guidelines." BJR|Open 2, no. 1 (2020): 20200007. http://dx.doi.org/10.1259/bjro.20200007.

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Objective: This study compares planning techniques stratified by consensus delineation guidelines in patients undergoing whole-breast radiotherapy based on an objective plan quality assessment scale. Methods: 10 patients with left-sided breast cancer were randomly selected, and target delineation for intact breast was performed using Tangent (RTOG 0413), ESTRO, and RTOG guidelines. Consensus Plan Quality Metric (PQM) scoring was defined and communicated to the physicist before commencing treatment planning. Field-in-field IMRT (FiF), inverse IMRT (IMRT) and volumetric modulated arc therapy (VM

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Zhao, Nan, Ruijie Yang, Yuliang Jiang, Suqing Tian, Fuxin Guo, and Junjie Wang. "A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/940102.

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Hybrid IMRT/VMAT technique which combined intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) was developed for the treatment of nasopharyngeal cancer (NPC). Two-full-arc VMAT (2ARC-VMAT), 9-field IMRT (9F-IMRT), and Hybrid IMRT/VMAT plans for NPC were compared in terms of the dosimetric quality, sparing of organs at risk (OARs), and delivery efficiency. The Hybrid IMRT/VMAT technique can improve the target dose homogeneity and conformity compared with 9F-IMRT and 2ARC-VMAT. It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified ti

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Chen, Shang-Wen, Ji-An Liang, Lian-Shung Yeh, Wei-Chun Chang, Wu-Chou Lin, and Chun-Ru Chien. "Does initial 45Gy of pelvic intensity-modulated radiotherapy reduce late complications in patients with locally advanced cervical cancer? A cohort control study using definitive chemoradiotherapy with high-dose rate brachytherapy." Radiology and Oncology 47, no. 2 (2013): 176–84. http://dx.doi.org/10.2478/raon-2013-0011.

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Background. Comparing initial 45 Gy of pelvic intensity-modulated radiation therapy (IMRT) and non-IMRT in terms of the late toxicities associated with advanced cervical cancer that has also been treated with definitive concurrent chemoradiotherapy and high-dose rate intracavitary brachytherapy (HDRICB). Patients and methods. This retrospective study included 320 stage IB2-IIIB cervical cancer patients treated with CCRT (83 IMRT and 237 non-IMRT). The two groups had similar stage and HDRICB ratings. Following 45 Gy to the pelvis, HDRICB of 24 Gy in four courses was prescribed. Late toxicities,

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Nutting, Christopher, Keith Rooney, Bernadette Foran, et al. "Results of a randomized phase III study of dysphagia-optimized intensity modulated radiotherapy (Do-IMRT) versus standard IMRT (S-IMRT) in head and neck cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): 6508. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.6508.

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6508 Background: Most newly diagnosed oro- & hypopharngeal cancers (OPC, HPC) are treated with (chemo)RT with curative intent but at the consequence of adverse effects on quality of life. CRUK/14/014 investigated if using Do-IMRT to reduce RT dose to the dysphagia/aspiration related structures (DARS) improved swallowing function compared to S-IMRT. Methods: Patients with T1-4, N0-3, M0 OPC/HPC were randomised 1:1 to S-IMRT (65 Gray (Gy)/30 fractions (f) to primary & nodal tumour; 54Gy/30f to remaining pharyngeal subsite & nodal areas at risk of microscopic disease) or Do-IMRT. The

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Eziokwu, Akaolisa Samuel, Shlomo A. Koyfman, Chandana A. Reddy, et al. "Incidence of severe late toxicities of head and neck squamous cell cancer (HNSCC) treatment in the era of intensity modulated radiotherapy (IMRT)." Journal of Clinical Oncology 37, no. 15_suppl (2019): e17570-e17570. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17570.

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e17570 Background: IMRT for HNSCC limits exposure to critical nearby structures thereby reducing toxicities. Real world data on toxicities after long term follow-up post IMRT for HNSCC are lacking. This study assessed the incidence of late toxicities in patients with HNSCC within 5 years post-treatment with definitive IMRT (d-IMRT). Methods: This is a retrospective, IRB approved, single-institution review of patients (pts) with stage I-IVB HNSCC treated with d-IMRT +/- chemotherapy between 2009 and 2013. The primary outcomes were incidence of severe late toxicities (dysphagia requiring esophag

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Rikitake, Ryoko, Yoichiro Tsukada, Mizuo Ando, et al. "Use of intensity-modulated radiation therapy for nasopharyngeal cancer in Japan: analysis using a national database." Japanese Journal of Clinical Oncology 49, no. 7 (2019): 639–45. http://dx.doi.org/10.1093/jjco/hyz042.

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Abstract Background Intensity-modulated radiation therapy (IMRT) yields better outcomes and fewer toxicities for radiation therapy (RT) of head and neck cancers (HNCs), including nasopharyngeal cancer (NPC). IMRT is the standard RT treatment and has been widely adopted in Western countries to treat HNCs. However, its uptake in clinical practice among NPC patients has never been studied. Methods We investigated the use of IMRT for NPC using data from a nationwide cancer registry to describe the use of IMRT among NPC patients in Japan. We analyzed the data of patients with HNC, including NPC, wh

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Pinnaduwage, Dilini S., Martina Descovich, Michael W. Lometti, Badri Varad, Mack Roach, and Alexander R. Gottschalk. "An Evaluation of Robotic and Conventional IMRT for Prostate Cancer: Potential for Dose Escalation." Technology in Cancer Research & Treatment 16, no. 3 (2016): 267–75. http://dx.doi.org/10.1177/1533034616639729.

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This study compares conventional and robotic intensity modulated radiation therapy (IMRT) plans for prostate boost treatments and provides clinical insight into the strengths and weaknesses of each. The potential for dose escalation with robotic IMRT is further investigated using the “critical volume tolerance” method proposed by Roach et al. Three clinically acceptable treatment plans were generated for 10 prostate boost patients: (1) a robotic IMRT plan using fixed cones, (2) a robotic IMRT plan using the Iris variable aperture collimator, and (3) a conventional linac based IMRT (c-IMRT) pla

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Daly, M. E., Y. Lieskovsky, T. Pawlicki, et al. "Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinomas." Journal of Clinical Oncology 24, no. 18_suppl (2006): 5536. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5536.

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5536 Background: Conventional RT (CRT) for head and neck squamous cell carcinoma (HNSCC) is associated with severe late side effects which can worsen quality of life of surviving patients. Intensity-modulated radiotherapy (IMRT) allows the delivery of tumoricidal doses to the target volume while maintaining tolerable doses to critical organs. Several previous studies have demonstrated promising results for tumor control and disease free survival for HNSCC treated with IMRT. In this study, we correlated patterns of failure with target volume delineations in HNSCC treated with IMRT at our instit

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Sakthivel, Vasanthan, Ganesh Kadirampatti Mani, Sunil Mani, and Raghavendiran Boopathy. "Radiation-induced second cancer risk from stereotactic ablative radiotherapy (SABR) for lung cancer: a review of planning studies." Journal of Radiotherapy in Practice 17, no. 2 (2017): 194–204. http://dx.doi.org/10.1017/s1460396917000528.

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AbstractPurposeThe aim of the current study was to (i) to calculate organ equivalent dose (OED) and (ii) to estimate excess absolute risks (EARs), lifetime attributable risks (LARs) and relative risks (RRs) from stereotactic ablative radiotherapy (SABR) for lung cancer to in-field, close to field, and out of field structures.MethodsA total of five patients with T1, T2 (≤4 cm), N0, M0 medically inoperable non-small cell lung cancer were selected for treatment planning. Patient selection criteria were based on RTOG 0236. Five treatment deliveries were investigated: (i) three-dimensional conforma

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Ibrahim, Mohamed S., Ehab M. Attalla, Mostafa El Naggar, and Wael M. Elshemey. "Dosimetric comparison between three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) in the treatment of different stages of nasopharyngeal carcinoma." Journal of Radiotherapy in Practice 18, no. 1 (2018): 46–51. http://dx.doi.org/10.1017/s1460396918000377.

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AbstractBackgroundThis work aims to compare the dosimetric performance of three-dimensional conformal radiotherapy (3D-CRT), a relatively available technique in developing countries, to intensity-modulated radiotherapy (IMRT) in the treatment of different stages of nasopharyngeal carcinoma (NPC).Materials and MethodsAccording to the diagnostic stages, 40 NPC patients were divided into two equal groups. Three planning techniques such as 3D-CRT, seven-field IMRT (7F-IMRT) and nine-field IMRT (9F-IMRT) were compared. Dose prescriptions of 70 and 66 Gy were delivered in 35 fractions to gross plann

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Marić, Slavica, Pavle Banović, Danijela Trokić, et al. "The importance of sophisticated techniques IMRT/VMAT: Impact on pulmonary toxicity reduction in radiotherapy of locally advanced lung cancer." Respiratio 15, no. 1-2 (2025): 116–26. https://doi.org/10.5937/respira2502116m.

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Aim-Implementation of sophisticated techniques IMRT/VMAT give possibility to escalate radiation dose and reduce pulmonary toxicity. 3D conformal radiotherapy was standard technique in lung cancer radiotherapy treatment. Aim of this study is dose volume parameters evaluation for organ of risk lungs between IMRT, VMAT, 3DCRT technique and evaluation of acute and late side effects for IMRT and VMAT technique. Patients and methods-This study included 70 patients with diagnosis lung carcinoma-study group A (VMAT technique) and study group B (IMRT ) treated with radical intent. 3D conformal plan was

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Azelie, Caroline, Mélanie Gauthier, Céline Mirjolet-Didelot, et al. "Exclusive image-guided IMRT versus radical prostatectomy followed by postoperative IMRT for localized prostate cancer: A matched-pair analysis based on risk groups." Journal of Clinical Oncology 30, no. 5_suppl (2012): 135. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.135.

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135 Background: To investigate whether patients treated for a localized prostate cancer require prior radical prostatectomy followed by postoperative radiotherapy or exclusive radiotherapy, in the modern era of image-guided IMRT. Methods: One hundred and seventy-eight patients with localized prostate cancer were referred for daily on-line exclusive image-guided IMRT (IG-IMRT), while 69 patients were referred for postoperative IMRT without image guidance after radical prostatectomy (RP+IMRT). The patients were matched in a 1:1 ratio according to their baseline risk group before any treatment. L

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Srivastava, Anoop Kumar, Atul Mishra, Sumanta Manna, Neha Yadav, Kailash Kumar Mittal, and Surendra Prasad Mishra. "Evaluation of tumor control probability and normal tissue complication probability in IMRT and VMAT: A comparative study for assessment of efficacy of radiotherapy plans in tumors of the thorax." Journal of Cancer Research and Therapeutics 21, no. 1 (2025): 131–36. https://doi.org/10.4103/jcrt.jcrt_1015_24.

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ABSTRACT Objective: The primary aim of radiation therapy planning is to achieve optimal tumor control probability (TCP) while minimizing the risk of normal tissue complications (NTCPs). Traditionally, the dose–volume histogram has been a reliable tool for evaluating volumetric dose distribution in treatment plans. This study aims to assess the radiobiological efficacy of volumetric modulated arc therapy (VMAT), step-and-shoot intensity-modulated radiation therapy (ss-IMRT), and dynamic IMRT (d-IMRT) in the treatment of thoracic tumors. Materials and Methods: This study involved 13 patients dia

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Zhao, Nan, Ruijie Yang, Junjie Wang, Xile Zhang, and Jinna Li. "An IMRT/VMAT Technique for Nonsmall Cell Lung Cancer." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/613060.

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The study is to investigate a Hybrid IMRT/VMAT technique which combines intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) for the treatment of nonsmall cell lung cancer (NSCLC). Two partial arcs VMAT, 5-field IMRT, and hybrid plans were created for 15 patients with NSCLC. The hybrid plans were combination of 2 partial arcs VMAT and 5-field IMRT. The dose distribution of planning target volume (PTV) and organs at risk (OARs) for hybrid technique was compared with IMRT and VMAT. The monitor units (MUs) and treatment delivery time were also evaluated. Hybrid

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Marshall, Deborah C., Zahra Ghiassi-Nejad, Allison Powers, et al. "A first radiotherapy application of functional bulboclitoris anatomy, a novel female sexual organ-at-risk, and organ-sparing feasibility study." British Journal of Radiology 94, no. 1124 (2021): 20201139. http://dx.doi.org/10.1259/bjr.20201139.

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Objective: The bulboclitoris (clitoris and vestibular bulbs) is the primary organ responsible for female sexual arousal and orgasm. Effects of radiotherapy on the bulboclitoris are unknown, as its structure/function has yet to be described in radiotherapy, and it overlaps only partially with the external genitalia structure. Our aim was to: describe bulboclitoris structure, function and delineation; compare volume of and dose delivered to the bulboclitoris vs external genitalia; and, compare bulboclitoris-sparing IMRT (BCS-IMRT) to standard IMRT (S-IMRT) to determine reoptimization feasibility

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Malik, Renuka, Julia L. Oh, John C. Roeske, and Arno J. Mundt. "Survey of Resident Education in Intensity-Modulated Radiation Therapy." Technology in Cancer Research & Treatment 4, no. 3 (2005): 303–9. http://dx.doi.org/10.1177/153303460500400310.

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Intensity-modulated radiation therapy (IMRT) has been gaining increasing popularity among practicing physicians in the U.S., but the extent to which radiation oncology residents are taught the principles of this technology and are trained to use IMRT remains unknown. In this paper, we assessed the current level of resident education in IMRT in the United States. Chief residents at all 77 accredited radiation oncology programs were sent a 13-question survey addressing formal didactics and hands-on experience in IMRT. The survey assessed the frequency, subject, and format of IMRT didactics. Ques

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Erraoudi, M., M. A. Youssoufi, F. Bentayeb, and M. R. Malisan. "A planning study to optimise a simultaneously integrated boost treatment of larynx cancer with seven intensity-modulated radiation therapy (IMRT) beams." Journal of Radiotherapy in Practice 17, no. 4 (2018): 447–54. http://dx.doi.org/10.1017/s1460396918000201.

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AbstractBackgroundIntensity-modulated radiation therapy (IMRT) is one of the most reported techniques for head and neck cancer treatment, as it allows a good coverage of the planning target volume (PTV) while sparing the surrounding organs at risk (OAR) better than conventional conformal radiotherapy. The objective of this work is to optimise an IMRT technique for the simultaneously integrated boost (SIB) treatment of larynx cancer delivering a total dose of 69·96 Gy to the boost volume and 54·45 Gy to the elective volume in 33 fractions.MethodsThree IMRT techniques, each using seven equally s

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Ding, Shouliang, Yongbao Li, Hongdong Liu, et al. "Comparison of Intensity Modulated Radiotherapy Treatment Plans Between 1.5T MR-Linac and Conventional Linac." Technology in Cancer Research & Treatment 20 (January 1, 2021): 153303382098587. http://dx.doi.org/10.1177/1533033820985871.

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In this study, we assess the dosimetric qualities and usability of planning for 1.5 T MR-Linac based intensity modulated radiotherapy (MRL-IMRT) for various clinical sites in comparison with IMRT plans using a conventional linac. In total of 30 patients with disease sites in the brain, esophagus, lung, rectum and vertebra were re-planned retrospectively for simulated MRL-IMRT using the Elekta Unity dedicated treatment planning system (TPS) Monaco (v5.40.01). Currently, the step-and-shoot (ss) is the only delivery technique for IMRT available on Unity. All patients were treated on an Elekta Ver

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Harris, Richard, Rollo Sheldon, Jane McNulty, and Scott Cherry. "Improving the safety of rapid tranquilisation in older people." BJPsych Open 7, S1 (2021): S28. http://dx.doi.org/10.1192/bjo.2021.129.

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AimsTo identify intramuscular rapid tranquilisation (IMRT) events in all >65 years inpatients in Sussex Partnership NHS Foundation Trust (SPFT) and to establish whether accompanying documentation meets SPFT guidelines. This is a re-audit, initial data were collected in 2016. Multimodal intervention has been implemented since initial data collection. In psychiatric inpatients IMRT should be administered as a last resort to calm acutely disturbed patients after verbal de-escalation and an offer of oral medication has failed. IMRT can cause physical health complications and impact therapeutic

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Welgemoed, Camarie, Simon Coughlan, Patti McNaught, Dorothy Gujral, and Pippa Riddle. "A dosimetric study to improve the quality of nodal radiotherapy in breast cancer." BJR|Open 3, no. 1 (2021): 20210013. http://dx.doi.org/10.1259/bjro.20210013.

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Objectives: Field-based planning for regional nodal breast radiotherapy (RT) used to be standard practice. This study evaluated a field-based posterior axillary boost (PAB) and two forward-planned intensity-modulated RT (IMRT) techniques, aiming to replace the first. Methods: Supraclavicular and axillary nodes, humeral head, brachial plexus, thyroid, and oesophagus were retrospectively delineated on 12 CT scans. Three plans, prescribed to 40.05 Gy, were produced for each patient. Breast plans consisted of field-in-field IMRT tangential fields in all three techniques. Nodal plans consisted of a

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Prayongrat, Anussara, Chakkapong Chakkabat, Danita Kannarunimit, Pokrath Hansasuta, and Chawalit Lertbutsayanukul. "Prevalence and significance of plasma Epstein-Barr Virus DNA level in nasopharyngeal carcinoma." Journal of Radiation Research 58, no. 4 (2017): 509–16. http://dx.doi.org/10.1093/jrr/rrw128.

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Abstract Epstein-Barr virus (EBV) DNA has been recognized as a promising tumor marker for nasopharyngeal carcinoma (NPC). This study aims to demonstrate the prevalence of plasma EBV DNA and its temporal correlation with treatment outcomes in the modern era. A total of 204 patients with Stage I–IVB NPC treated with intensity-modulated radiotherapy (IMRT) were enrolled. Quantitative plasma EBV DNA measurement was performed before treatment (pre-IMRT), on the fifth week of radiation (mid-IMRT), at 3 months after radiation (post-IMRT), then every 6 months until disease relapse. Progression-free su

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Balermpas, Panagiotis, Janita E. van Timmeren, David J. Knierim, Matthias Guckenberger, and Ilja F. Ciernik. "Dental extraction, intensity-modulated radiotherapy of head and neck cancer, and osteoradionecrosis." Strahlentherapie und Onkologie 198, no. 3 (2022): 219–28. http://dx.doi.org/10.1007/s00066-021-01896-w.

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Abstract Objective To seek evidence for osteoradionecrosis (ORN) after dental extractions before or after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC). Methods Medline/PubMed, Embase, and Cochrane Library were searched from 2000 until 2020. Articles on HNC patients treated with IMRT and dental extractions were analyzed by two independent reviewers. The risk ratios (RR) and odds ratios (OR) for ORN related to extractions were calculated using Fisher’s exact test. A one-sample proportion test was used to assess the proportion of pre- versus post-IMRT extractions. Forest

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Hsieh, Chen-Hsi, Pei-Wei Shueng, Li-Ying Wang, et al. "Single-Institute Clinical Experiences Using Whole-Field Simultaneous Integrated Boost (SIB) Intensity-Modulated Radiotherapy (IMRT) and Sequential IMRT in Postoperative Patients With Oral Cavity Cancer (OCC)." Cancer Control 27, no. 1 (2020): 107327482090470. http://dx.doi.org/10.1177/1073274820904702.

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This study aimed to review clinical experiences using whole-field simultaneous integrated boost (SIB) intensity-modulated radiotherapy (IMRT) and sequential IMRT in postoperative patients with oral cavity cancer (OCC). From November 2006 to December 2014, a total of 182 postoperative patients with OCC who underwent either SIB-IMRT (n = 63) or sequential IMRT (n = 119) were enrolled retrospectively and matched randomly according to multiple risk factors by a computer. The differences were well balanced after patient matching ( P = .38). The median follow-up time was 65 months. For patients trea

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Raturi, Vijay P., Atsushi Motegi, Sadamoto Zenda, et al. "Comparison of a Hybrid IMRT/VMAT technique with non-coplanar VMAT and non-coplanar IMRT for unresectable olfactory neuroblastoma using the RayStation treatment planning system—EUD, NTCP and planning study." Journal of Radiation Research 62, no. 3 (2021): 540–48. http://dx.doi.org/10.1093/jrr/rrab010.

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Abstract The purpose of this study was to compare hybrid intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (Hybrid IMRT/VMAT), with non-coplanar (nc) IMRT and nc-VMAT treatment plans for unresectable olfactory neuroblastoma (ONB). Hybrid IMRT/VMAT, nc-IMRT and nc-VMAT plans were optimized for 12 patients with modified Kadish C stage ONB. Dose prescription was 65 Gy in 26 fractions. Dose–volume histogram parameters, conformation number (CN), homogeneity index (HI), integral dose and monitor units (MUs) delivered per fraction were assessed. Equivalent uniform dose (EUD

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