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Journal articles on the topic 'In situ gelling'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Vyas, Urvashi, Narendra Gehalot, Vikas Jain, and S. C. Mahajan. "Formulation and Evaluation of Norfloxacin Ocular In-situ Gel." Journal of Drug Delivery and Therapeutics 12, no. 5-S (2022): 123–26. http://dx.doi.org/10.22270/jddt.v12i5-s.5644.

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The study aims to prepare and evaluate the in situ Norfloxacin gel for the treatment of Conjunctivitis. The pronounced fluctuations and repeated administration of conventional eye drops are the main disadvantages of ophthalmic drug delivery. The ocular in situ gelling system is designed to achieve a prolonged therapeutic effect by improving residence time at the application site. Infrared spectroscopy studies of Norfloxacin, Sodium alginate, Gellan gum, and HPMC K4M alone and their physical mixture revealed that Norfloxacin is compatible with all the polymers used. The Ophthalmic in situ gelli

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2

Abhishek, Saini, Pawar Rajat, and Dubey P.K. "A REVIEW ON OCULAR IN SITU GEL." International Journal of Pharmaceutical Sciences and Medicine 7, no. 4 (2022): 18–30. http://dx.doi.org/10.47760/ijpsm.2022.v07i04.002.

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Ophthalmic drug delivery presents major challenges for pharmaceutical and medicinal sciences. New ocular drug delivery forms are various; they included in situ gelling systems, liposome’s, nanoparticles, noisome, nanoemulsions and microemulsions. They are suitable for hydrophilic or lipophilic drugs, have the capacity of targeting a specific site and can be administrated in different routes. With the appropriate excipients, in situ gelling systems are able to increase the precorneal residence time and decrease the loss of drug due to the tear. In situ gelling system is a formulation that is in

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3

Sarada, K., S. Firoz, and K. Padmini. "In-Situ Gelling System: A Review." International Journal of Current Pharmaceutical Review and Research 5, no. 4 (2014): 76–90. https://doi.org/10.5281/zenodo.12688847.

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Current review on in-situ gelling system explains about gels which are defined as intermediatestate of matter consists of liquid and solid components. Hydrogels are also briefly discussed inthe review that is defined as three dimensional structures which has capacity to retain bulkamount of water and also biological fluids to swell. In-situ gels are type of hydrogels that aresolution in form and undergo gelation in contact with body fluids or change in pH. Some of thepolymers that are used in in-situ gelling system are guar gum, gellan gum, xanthan gum,carrageenan, xyloglucan, pectin, chitosan

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4

Liow, Sing Shy, Qingqing Dou, Dan Kai, et al. "Thermogels: In Situ Gelling Biomaterial." ACS Biomaterials Science & Engineering 2, no. 3 (2016): 295–316. http://dx.doi.org/10.1021/acsbiomaterials.5b00515.

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5

Khairnar, Ms Rajeshwari G. "Comprehensive Review on Polymers Used in Insitu Gelling System." International Journal for Research in Applied Science and Engineering Technology 12, no. 5 (2024): 1659–63. http://dx.doi.org/10.22214/ijraset.2024.61900.

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Abstract: In situ gelling formulations are drug delivery systems which typically exist in a liquid form at room temperature and change into gel state after application to the body in response to various stimuli such as changes in temperature, pH and ionic composition.[1] In situ gels have become one of the most prominent and accessible systems. These systems have several advantages like simple manufacturing, easy to use, improved adherence, and patient comfort by minimizing drug administration frequency by its unique characteristic features of sol to gel transition. In the 'sol-gel' method, th

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Apriliyani, Bella Khofila, Sani Ega Priani, and Aulia Fikri Hidayat. "Rancangan Pengembangan Sediaan Nanospraygel in situ Mengandung Minyak Kulit Batang Kayu Manis (Cinnamomum burmannii (Nees & T. Nees) Blume) untuk Pengobatan Kandidiasis Oral." Jurnal Riset Farmasi 1, no. 1 (2021): 64–72. http://dx.doi.org/10.29313/jrf.v1i1.187.

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Abstract. Cinnamon bark oil is known to have antifungal activity so it can be used for oral candidiasis treatment. Thick and impenetrable oral mucosa needs to be treated with modification. Development of in situ nanospraygel can increase the effectiveness and reduce the risk of contamination of the preparation. This study tries to investigate the antifungal activity of cinnamon bark oil, determine suitable formula for the cinnamon bark oil nanoemulsion, and determine the type of gelling agent that can be used to develop in situ nanospraygel. The design of in situ nanospraygel formula containin

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Enin, Amal S. M. Abu El. "Formulation and Evaluation of In-situ Gelling Tenoxicam Liquid Suppositories." Journal of Life Medicine 01, no. 02 (2013): 23–32. http://dx.doi.org/10.14511/jlm.2013.010202.

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8

Vigani, Barbara, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni, Carla M. Caramella, and Franca Ferrari. "Recent Advances in the Development of In Situ Gelling Drug Delivery Systems for Non-Parenteral Administration Routes." Pharmaceutics 12, no. 9 (2020): 859. http://dx.doi.org/10.3390/pharmaceutics12090859.

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In situ gelling drug delivery systems have gained enormous attention over the last decade. They are in a sol-state before administration, and they are capable of forming gels in response to different endogenous stimuli, such as temperature increase, pH change and the presence of ions. Such systems can be administered through different routes, to achieve local or systemic drug delivery and can also be successfully used as vehicles for drug-loaded nano- and microparticles. Natural, synthetic and/or semi-synthetic polymers with in situ gelling behavior can be used alone, or in combination, for th

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9

Lee, Bae Hoon, and Brent Vernon. "In Situ-Gelling, ErodibleN-Isopropylacrylamide Copolymers." Macromolecular Bioscience 5, no. 7 (2005): 629–35. http://dx.doi.org/10.1002/mabi.200500029.

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10

Miyazaki, Shozo, Hirotatsu Aoyama, Naoko Kawasaki, Wataru Kubo, and David Attwood. "In situ-gelling gellan formulations as vehicles for oral drug delivery." Journal of Controlled Release 60, no. 2-3 (1999): 287–95. http://dx.doi.org/10.1016/s0168-3659(99)00084-x.

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11

Shaikh, Bilal Jilani, Indrayani D. Raut, Manojkumar M. Nitalikar, Shrinivas K. Mohite, and Chandrakant S. Magdum. "An Overview on In-Situ Gel: A Novel Drug Delivery System." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 5 (2022): 6180–89. http://dx.doi.org/10.37285/ijpsn.2022.15.5.10.

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Controlled and sustained drug delivery has recently become the industry standard, and extensive research has been conducted in order to improve drug product effectiveness, reliability, and safety. The ‘in-situ gel' system has emerged as one of the best innovative drug delivery systems; its unique feature of ‘Sol to Gel' transition aids in the sustained and controlled release of drugs. A formulation that is in solution form before entering the body, but changes to gel form under certain physiological conditions, is known as an in-situ gelling system. The advantages of in-situ forming polymeric

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12

Mahajan, Hitendra, Hannan Shaikh, Surendra Gattani, and Pankaj Nerkar. "In-Situ Gelling System based on Thiolated Gellan Gum as New Carrier for Nasal Administration of Dimenhydrinate." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 2 (2009): 544–50. http://dx.doi.org/10.37285/ijpsn.2009.2.2.8.

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The purpose of the present study was to develop intranasal delivery system of dimenhydrinate using thiolated gellan gum and formulations were modulated so as to have gelation at physiological ion content after intranasal administration. Gelation was determined by physical appearance. The mucoadhesive force in terms of detachment stress, determined using sheep nasal mucosa, increased with increasing concentration of thiolated polymer. The results of in vitro drug permeation studies across sheep nasal mucosa indicate that effective permeation could be significantly increased by using in situ gel

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13

Deshmukh, Mr Vikram Tanaji, and Dr Jagdish Chandra Pati. "Development and Evaluation of In-Situ Floating Gel In treatment of Gastroesophageal Reflux Disease (Gerd)." Journal of Drug Discovery and Therapeutics 11, no. 2 (2023): 70–92. http://dx.doi.org/10.32553/jddt.v11i2.466.

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Gastroretentive drug delivery systems can deliver narrow-window drugs to the upper stomach at a controlled rate. The raft forming process is better than floating structures, liquid dosing mediums, and in situ gelation for sustained drug release in the upper GI tract. According to statistics, lafutidine is exactly put in the parietal cells of the stomach mucosa, where the upper gastro-intestinal tract absorbs it. Lafutidine capsules had 65–70% bioavailability compared to intravenous infusion. Stability and absorption are acceptable between 1 and 4. The colon and lower gastrointestinal tract deg

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14

Destruel, Pierre-Louis, Ni Zeng, Françoise Brignole-Baudouin, et al. "In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics." Pharmaceutics 12, no. 4 (2020): 360. http://dx.doi.org/10.3390/pharmaceutics12040360.

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Mydriasis is required prior to many eye examinations and ophthalmic surgeries. Nowadays, phenylephrine hydrochloride (PHE) and tropicamide (TPC) are extensively used to induce mydriasis. Several pharmaceutic dosage forms of these two active ingredients have been described. However, no optimal therapeutic strategy has reached the market. The present work focuses on the formulation and evaluation of a mucoadhesive ion-activated in situ gelling delivery system based on gellan gum and hydroxyethylcellulose (HEC) for the delivery of phenylephrine and tropicamide. First, in vitro drug release was st

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15

Siripruekpong, Worrawee, Rachanida Praparatana, Ousanee Issarachot, and Ruedeekorn Wiwattanapatapee. "Simultaneous Delivery of Curcumin and Resveratrol via In Situ Gelling, Raft-Forming, Gastroretentive Formulations." Pharmaceutics 16, no. 5 (2024): 641. http://dx.doi.org/10.3390/pharmaceutics16050641.

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Curcumin and resveratrol are polyphenolic compounds that have been shown to exhibit synergistic therapeutic properties including anti-inflammatory, anticancer, and antiulcer activities, which may be exploited for the treatment of gastric diseases. However, both compounds have poor aqueous solubility and rapid metabolism, resulting in a low oral bioavailability. In situ gelling, liquid formulations were developed to produce a gastroretentive, raft-forming delivery vehicle to improve bioavailability. Solid dispersions containing a mixture of curcumin and resveratrol with Eudragit® EPO (Cur/Res-S

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16

S.Yousif, Hala, and Yehia I. Khalil. "In Situ Gelling Formulation of Naproxen for Oral Sustained Delivery System." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, no. 1 (2017): 13–20. http://dx.doi.org/10.31351/vol18iss1pp13-20.

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Naproxen is non-steroidal anti-inflammatory drug, which has antipyretic and anti-inflammatory effect. It is extensively bound to plasma albumin, and exhibits gastric toxicity, so it may be more efficient to deliver the drug in its sustained release dosage form and adequate blood level is achieved. Three liquid formulations with in situ gelling properties have been assessed for their potential for the oral sustained delivery of naproxen . The formulations were dilute solutions of: (a) pectin; (b) gellan gum and; (c) sodium alginate, all containing complexed calcium ion that form gels when these

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17

Akash, Muktiram Shendge* Vikas B. Wamane Jayshree R. Shejul. "A Review on In Situ Gelling System." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 448–62. https://doi.org/10.5281/zenodo.12679670.

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Controlled and sustained drug delivery has become a novelty in recent years Modern drug design standards and in-depth research Steps have been taken to achieve significantly better drug efficacy. Reliability and security. In situ gel systems have become one of the most innovative systems in recent years. New drug delivery systems have Advantages such as prolonged drug effect and patient improvement Comparing compliance and reducing dosing frequency Traditional drug delivery systems (DDS). In this system This preparation is in the form of a solution and after contact with It condenses into a ge

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18

Maheswaran, A., J. Padmavathy, V. Nandhini, D. Saravanan, and P. Angel. "FORMULATION AND EVALUATION OF FLOATING ORAL IN SITU GEL OF DILTIAZEM HYDROCHLORIDE." International Journal of Applied Pharmaceutics 9, no. 1 (2016): 50. http://dx.doi.org/10.22159/ijap.2017v9i1.15914.

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Objective: The objective of the present study was to formulate and evaluate the floating in-situ gelling system of diltiazem hydrochloride.Methods: Sodium alginate based diltiazem hydrochloride floating in situ gelling systems were prepared by dissolving hydroxyl propyl methyl cellulose (HPMC) in 25% of water, to which calcium carbonate and diltiazem hydrochloride were added with stirring to form, a proper and a homogenous dispersion of diltiazem hydrochloride. Meanwhile, 30% of water was heated to 60 ˚C on a hot plate to dissolve sodium alginate and cooled to 40 ˚C. The resulting solution was

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19

Kurniawansyah, Insan Sunan, Taofik Rusdiana, Iyan Sopyan, Insi Farisa Desy Arya, Habibah A. Wahab, and Dela Nurzanah. "Comparative Study of In Situ Gel Formulation Based on the Physico-Chemical Aspect: Systematic Review." Gels 9, no. 8 (2023): 645. http://dx.doi.org/10.3390/gels9080645.

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In recent years, in situ gel delivery systems have received a great deal of attention among pharmacists. The in situ gelation mechanism has several advantages over ointments, the most notable being the ability to provide regular and continuous drug delivery with no impact on visual clarity. Bioavailability, penetration, duration, and maximum medication efficacy are all improved by this mechanism. Our review systematically synthesizes and discusses comparisons between three types of in situ gelling system according to their phase change performance based on the physicochemical aspect from publi

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S., G. Patil* S. R. Shahi J. J. Dandale R. M. Savakhande. "In-Situ Gel: A Gastro-retentive Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 258–73. https://doi.org/10.5281/zenodo.14603429.

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Conventional oral dosage forms have low bioavailability due to their rapid gastric transition from the stomach, especially for drugs that are less soluble at the alkaline pH of the intestine. Similar to this, medications that have a local effect in the stomach are quickly evacuated and do not have enough time to remain there. To avoid this problem, numerous attempts have been made to prolong the retention duration of the drug delivery method. We will talk about the several methods used to create gastro-retention in drug delivery systems with a focus on the floating in-situ gel system for stoma

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21

M, Sindhoor S., Sneh Priya, and Amala Maxwell. "FORMULATION AND EVALUATION OF NOVEL IN SITU GEL OF LAFUTIDINE FOR GASTRO RETENTIVE DRUG DELIVERY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 88. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.25582.

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Objective: The aim of the present study was to formulate and evaluate the novel in situ gel of lafutidine for gastroretentive drug deliveryMethods: A gastroretentive in situ gel of lafutidine was formulated by pH-triggered ionic gelation method using different concentrations of gelling polymer such as sodium alginate, gellan gum, and xanthum gum. Prepared formulations were evaluated for viscosity, density, buoyancy lag time and buoyancy duration, and drug content. In vitro drug release studies of all formulations were also performed. In vivo fluorescence imaging study was conducted for optimiz

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22

Patel, Dasharath M., Divyesh K. Patel, and Chhagan N. Patel. "Formulation and Evaluation of Floating Oral In Situ Gelling System of Amoxicillin." ISRN Pharmaceutics 2011 (July 28, 2011): 1–8. http://dx.doi.org/10.5402/2011/276250.

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Purpose. Effective Helicobacter pylori eradication requires delivery of the antibiotic locally in the stomach. High dose of amoxicillin (750 to 1000 mg) is difficult to incorporate in floating tablets but can easily be given in liquid dosage form. Keeping the above facts in mind, we made an attempt to develop a new floating in situ gelling system of amoxicillin with increased residence time using sodium alginate as gelling polymer to eradicate H. pylori. Methods. Floating in situ gelling formulations were prepared using sodium alginate, calcium chloride, sodium citrate, hydroxypropyl methyl ce

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Tejas, Pawar* Dr. Anil Pawar Dr. V. K. Deshmukh. "A Review on Thermoresponsive In-Situ Gel." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 406–14. https://doi.org/10.5281/zenodo.15582636.

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Thermoresponsive gels, also known as thermogels or thermo-sensitive hydrogels, are materials that undergo a sol-to-gel or gel-to-sol transition in response to temperature changes [1] Thermoresponsive gelling materials constructed from natural and synthetic polymers can be used to provide triggered action and therefore customized products such as drug delivery and regenerative medicine types as well as for other industries. In situ gelling formulations are drug delivery systems which typically exist in a liquid form at room temperature and change into gel state after application to the body in

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Ashutosh, Pareek, Jain Vivek, Ratan Yashumati, and Singh Ashawat Mahendra. "A New Validated UV Spectrophotometric Method for Quantitative Determination of Pefloxacin Mesylate in Bulk Form and Developed In-Situ Gelling Ocular Formulations." Pharmaceutical and Chemical Journal 2, no. 2 (2015): 52–59. https://doi.org/10.5281/zenodo.13695076.

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The present study was conducted to develop a new simple, rapid, precise, sensitive, eco-friendly <em>UV-</em>spectroscopic method for the quantitative determination of Pefloxacin Mesylate in bulk form and prepared <em>in-situ</em> gelling ocular formulations. Method was successfully developed in simulated tear fluid pH 7.4 and further validated in accordance with International Conference on Harmonization (ICH) Q2B guidelines. In line to this, it was tested for linearity, accuracy, precision, detection limit, quantification limit, stability testing, Sandell’s sensitivity and molar absorpt

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Eram, Fatima, and ,. Vivek. "In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery." Journal of Drug Delivery and Therapeutics 10, no. 5-s (2020): 32–39. http://dx.doi.org/10.22270/jddt.v10i5-s.4421.

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Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug.

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Damagundam, Srilakshmi, Pooja Jupally, and D. Prasanthi. "Intranasal In-Situ Gelling Systems: An Approach for Enhanced CNS Delivery of Drugs." International Journal of Pharmaceutical and Clinical Research 15, no. 4 (2023): 484–97. https://doi.org/10.5281/zenodo.12667625.

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The oral route is the one that is most frequently used for drug administration. Unfortunately, this oral route is not the best for the delivery of several medications because of gastrointestinal breakdown and substantial hepatic first-pass metabolism. As an alternative, the nasal route can be chosen to deliver drugs via the olfactory and trigeminal neurons directly to the brain bypassing the blood-brain barrier (BBB). The advantages of the nasal route are its non-invasiveness, and self-medication. The main drawback of this route is the quick mucociliary clearance, which leads to low absorption

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El-Kamel, Amal, and Mona El-Khatib. "Thermally Reversible In Situ Gelling Carbamazepine Liquid Suppository." Drug Delivery 13, no. 2 (2006): 143–48. http://dx.doi.org/10.1080/10717540500316003.

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Guo, Qiongyu, Ahmed Aly, Oliver Schein, Morgana M. Trexler, and Jennifer H. Elisseeff. "Moxifloxacin in situ gelling microparticles–bioadhesive delivery system." Results in Pharma Sciences 2 (2012): 66–71. http://dx.doi.org/10.1016/j.rinphs.2012.09.002.

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Haglund, Bert O., Rajashree Joshi, and Kenneth J. Himmelstein. "An in situ gelling system for parenteral delivery." Journal of Controlled Release 41, no. 3 (1996): 229–35. http://dx.doi.org/10.1016/0168-3659(96)01333-8.

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Ahmed, Bakr, Srishty Jaiswal, Srishti Naryal, Rohan M. Shah, Raid G. Alany, and Indu Pal Kaur. "In situ gelling systems for ocular drug delivery." Journal of Controlled Release 371 (July 2024): 67–84. http://dx.doi.org/10.1016/j.jconrel.2024.05.031.

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31

Pashikanti, Shailaja, and Jyothsna B. "FORMULATION AND EVALUATION OF FLOATING IN SITU GEL OF CIPROFLOXACIN." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 198. http://dx.doi.org/10.22159/ijap.2019v11i1.28603.

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Objective: The objective of the study was to develop floating in situ gel formulations of Ciprofloxacin that has a narrow absorption window and mainly absorbed in the proximal areas of GIT. These formulations increases the targeted action on bacteria for a longer time that can be used in the treatment of Helicobacter pylori (H. pylori) infections and urinary tract infections.Methods: In situ gel formulations were prepared by varying concentrations of sodium alginate as in situ gel forming bio-degradable polymer and calcium carbonate as a cross-linking agent. The formulations were evaluated for

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Shirodker, A., S. Bhangle, and R. Gude. "FORMULATION DEVELOPMENT AND EVALUATION OF AN IN SITU OPHTHALMIC GELLING SYSTEM OF BRIMONIDINE TARTRATE AND TIMOLOL MALEATE FOR THE TREATMENT OF GLAUCOMA." INDIAN DRUGS 54, no. 02 (2017): 76–78. http://dx.doi.org/10.53879/id.54.02.10854.

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The present study involved formulation of an in situ gelling system of brimonidine tartrate and timolol maleate for the treatment of glaucoma. Carbopol® 980 NF, xanthum gum and hydroxypropyl methylcellulose K4 M were used as polymers. The prepared in situ gelling systems were evaluated for clarity, appearance, texture analysis, pH, viscosity, rheological properties, in vitro gelation, isotonicity, drug content uniformity, in vitro release studies, microbiological evaluation, ex vivo release studies and stability testing. The results of the attenuated total reflectance spectroscopy and differen

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Mardikasari, Sandra Aulia, Mária Budai-Szűcs, László Orosz, Katalin Burián, Ildikó Csóka, and Gábor Katona. "Development of Thermoresponsive-Gel-Matrix-Embedded Amoxicillin Trihydrate-Loaded Bovine Serum Albumin Nanoparticles for Local Intranasal Therapy." Gels 8, no. 11 (2022): 750. http://dx.doi.org/10.3390/gels8110750.

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A high dose of amoxicillin is recommended as the first-line therapy for acute bacterial rhinosinusitis (ABR). However, oral administration of amoxicillin is connected to many adverse reactions coupled with moderate bioavailability (~60%). Therefore, this study aimed to develop a topical nasal preparation of amoxicillin, employing a thermoresponsive nanogel system to increase nasal residence time and prolong drug release. Rheological investigations revealed that formulations containing 21–23% w/w Poloxamer 407 (P407) were in accordance with the requirement of nasal administration (gelling tempe

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Malviya, Vedanshu, Mukund Tawar, Prashant Burange, and Ritu Bairagi. "Preparation and Characterization of Gastroreten-tive Sustained Release In-situ Gel of Lafutidine." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 6 (2022): 6216–28. http://dx.doi.org/10.37285/ijpsn.2022.15.6.4.

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Background: The in-situ solutions, which float in the gastrointestinal region after gelation, is suited for long-term drug release. In this study, natural and synthetic polymers were used to try to build a Gastro-Retentive controlled release in-situ gel. To modulate the rate of drug distribution and increase bioavailability and stability, gastro-retentive controlled release in-situ gels were prepared.  Materials and Methods: For this project, 32 factorial designs were chosen. The two independent variables were sodium alginate (X1) and the ratio of HPMC K100M: Gellan Gum (X2) was preserve

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Abhishek, Soni 1. *. Dr. Amit Chaudhary 1. Dr. Shivali Singla 2. Dr. Sachin Goyal 2. "REVIEW ON: NOVEL APPROACH IN PHARMACEUTICAL GEL." Journal of Pharma Research 8, no. 6 (2019): 429–35. https://doi.org/10.5281/zenodo.3265342.

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<strong><em>ABSTRACT</em></strong> <strong><em>R</em></strong><em>eview on novel approach in pharmaceutical gel explains about gels and its novel development as hydrogel. Gel which is defined as intermediate state of matter consists of liquid and solid components. Hydrogels are also briefly discussed in the review that is defined as three dimensional structures which has capacity to retain bulk amount of water and also biological fluids to swell. In novel approach in pharmaceutical gel is In-Situ gels. In-situ gels are type of hydrogels that are solution in form and undergo gelation in contact

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Brahmavale, Maithili. "From Liquid to Solid: Unravelling the Magic of In-Situ Gels." International Journal for Research in Applied Science and Engineering Technology 12, no. 5 (2024): 3829–37. http://dx.doi.org/10.22214/ijraset.2024.62471.

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Abstract: In situ gelling formulations are liquid at room temperature and transform into gels upon application to the body in response to various stimuli (e.g., pH, temperature, ionic composition). Incorporating drug nanoparticles into these systems enhances their biomedical utility by prolonging drug release, reducing dosing frequency, and improving patient outcomes. These formulations, particularly those with mucoadhesive polymers, offer promising potential for targeted drug delivery and prolonged drug retention at specific sites. A review of clinical properties of in situ gelling systems in

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TABASSUM, SAMIA, HAFIZ SHOAIB SARWAR, MUHAMMAD SAFRAZ, et al. "THERMOSENSITIVE SOL-GEL SYSTEM CONTAINING VANCOMYCIN-LOADED THIOMERIC NANOPARTICLES FOR ENHANCED PERMEATION ACROSS NASAL MEMBRANE." Cellulose Chemistry and Technology 58, no. 9-10 (2024): 1065–74. https://doi.org/10.35812/cellulosechemtechnol.2024.58.91.

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During oral delivery, vancomycin (VAN) is prone to enzymatic degradation and therefore, an intra-nasal highly mucoadhesive system, having enhanced nasal residence time, is considered in this study as an alternative way for vancomycin delivery. It was aimed to develop highly mucoadhesive in-situ gelling nanoparticles (NPs) by combining two mucoadhesive technologies: i.e. thiolation and thermosetters for nasal delivery of vancomycin. For this purpose, thiolated chitosan was synthesized, and the degree of thiolation was determined via Ellman’s test. In the next step, vancomycin-loaded nanoparticl

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Dorwal, Dhawal, and Ravikant Gupta. "Formulation and Characterization of Novel Floating Raft Forming In-situ Gel for Delivery of BCS Class II Drugs." Journal of Neonatal Surgery 14, no. 4S (2025): 1133–50. https://doi.org/10.52783/jns.v14.1924.

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The main objective of the research was to formulate an oral raft-forming in situ gelling system of Albendazole (ABZ) to improve gastric retention and drug release in a controlled manner and remain floating in the stomach for a prolonged time. In this study in situ gelling system was developed and optimized by a two-factor at three-level (32) factorial design. It was analyzed to study the impact of two independent variables vizGellan gum [A] and Carbapol 934 P [B] on the responses, such as floating lag time, percentage (%) water uptake at 2 h, and % drug release at 6 h and 12 h. An in vitro gel

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Sanjeevani Shekhar Deshkar, Rutuja Prakash Bokare, and Suhas Ashok Todmal. "Formulation and Evaluation of Microemulsion Based in Situ Gel of Acyclovir for Vaginal Delivery." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6336–46. http://dx.doi.org/10.26452/ijrps.v11i4.3389.

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The purpose of the present study was to formulate and evaluate microemulsion based in situ gel of Acyclovir (ACV) for the vaginal delivery. The solubility of ACV in oils and surfactants and co-surfactant was evaluated to identify the components of the microemulsion. Microemulsion region was determined by using the pseudo-ternary phase diagrams for different formulations. Microemulsion formulation was prepared using Labrafil M1994C as oil phase, Cremophor RH40 as surfactant and Polyethylene glycol 400 and Transcutol P as co-surfactant and water. Microemulsion formulations were evaluated for pH,

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Dubey, A., P. Prabhu, N. Nair, K. Beladiya, and V. Ghate. "DEVELOPMENT AND INVESTIGATION OF TIMOLOL MALEATE AND TRAVOPROST COMBINATION NIOSOMAL IN SITU GELLING SYSTEM FOR THE TREATMENT OF GLAUCOMA." INDIAN DRUGS 52, no. 07 (2015): 33–35. http://dx.doi.org/10.53879/id.52.07.10193.

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The aim of the present investigation was to develop a combination of timolol maleate and travoprost niosomal in situ gelling system for the treatment of glaucoma. Niosomes were prepared by thin film hydration technique using rotary flash evaporator. A 32 factorial design was utilized to study the effect of the molar ratio of Span 60 (X1) and cholesterol (X2) on vesicle size, drug entrapment efficiency and in vitro release study. On the basis of vesicle size, maximum entrapment efficiency and in vitro release of drug, best formulations were selected for the preparation of niosomal in situ gel (

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Zhou, Shuwen, Xinmeng Zheng, Ke Yi, et al. "Temperature-Ion-pH Triple Responsive Gellan Gum as In Situ Hydrogel for Long-Acting Cancer Treatment." Gels 8, no. 8 (2022): 508. http://dx.doi.org/10.3390/gels8080508.

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Background: Promising cancer chemotherapy requires the development of suitable drug delivery systems (DDSs). Previous research has indicated that a hydrogel is a powerful DDS for tumor therapy and holds great potential to offer a feasible method for cancer management. Methods: In this study, glutathione-gellan gum conjugate (GSH-GG) was synthesized through chemical reaction. Doxorubicin hydrochloride (DOX) was loaded into GSH-GG to accomplish DOX-loaded GSH-GG. The properties, injectability, drug release, and in vitro and in vivo anticancer effects of DOX-loaded GSH-GG were tested. Results: DO

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Kubo, W. "Oral sustained delivery of paracetamol from in situ-gelling gellan and sodium alginate formulations." International Journal of Pharmaceutics 258, no. 1-2 (2003): 55–64. http://dx.doi.org/10.1016/s0378-5173(03)00163-7.

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Jelkmann, Max, Christina Leichner, Sergey Zaichik, Flavia Laffleur, and Andreas Bernkop-Schnürch. "A gellan gum derivative as in-situ gelling cationic polymer for nasal drug delivery." International Journal of Biological Macromolecules 158 (September 2020): 1037–46. http://dx.doi.org/10.1016/j.ijbiomac.2020.04.114.

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Rohith, Ganapati, Bhimagoni Sridhar, and Anegundha Srinatha. "Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation." Acta Pharmaceutica 59, no. 3 (2009): 345–54. http://dx.doi.org/10.2478/v10007-009-0021-z.

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Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation In the present work, a gastroretentive in situ gelling liquid formulation for controlled delivery of ranitidine was formulated using sodium alginate (low, medium and high viscosity grades), calcium carbonate (source of cations) and ranitidine. Prepared formulations were evaluated for viscosity, buoyancy lag time and buoyancy duration, drug content and in vitro drug release. Formulation variables such as concentration of sodium alginate, calcium carbonate and drug significantly affe

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Yuan, Le, Lijun Ren, Xingtao Tian, et al. "Investigation on polyvinyl-alcohol-based rapidly gelling hydrogels for containment of hazardous chemicals." RSC Advances 6, no. 75 (2016): 71425–30. http://dx.doi.org/10.1039/c6ra14032g.

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Ashish, Gorle, Yadav Rahul, Rathod Mukesh, and Mali Prakash. "FORMULATION AND EVALUATION OF IN-SITU GEL CONTAINING CIPROFLOXACIN HYDROCHLORIDE IN THE TREATMENT OF PERIODONTITIS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 6 (2017): 154. http://dx.doi.org/10.22159/ajpcr.2017.v10i6.17558.

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Objective: The present study describes the use of in-situ gel in periodontal drug delivery systems which contains gellan gum (0.4–0.6% w/v), pluronic F127 (14, 15 and 16% w/v), and drug Ciprofloxacin HCl (0.1% w/v). Number of peoples around the world suffered from dental problem and ultimate fear is tooth loss hence in-situ gelling system was designed for the treatment of periodontal diseases. The therapeutic efficacy of drug can be greatly improved by prolonging its contact time.Methods: Formulations were developed by simple solution method. Each formulation was characterized in terms of in g

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Kurniawansyah, Insan Sunan, Insi Farisa Desy Arya, Arif Budiman, and And Zubaidah. "A Comparative Study on The Therapeutic Effect of pH, Temperature Triggered, and Ion Activated In Situ Gelling System For Ocular Delivery." Indonesian Journal of Pharmaceutics 6, no. 2 (2025): 119–27. https://doi.org/10.24198/idjp.v6i2.52695.

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One of the most popular pharmaceutical preparations for the eyes today is in situ gel. The in situ gel system is a system that is liquid at room temperature but will form a gel when it comes into contact with the body or undergoes a change in pH. The form of the drug delivery system is in-situ is a type of mucoadhesive drug delivery system. Gel formation depends on several factors such as temperature modulation, pH changes, the presence of ions, ultra-violet irradiation, electrical sensitivity, and the enzyme by which the active substance is released. The purpose of this study is to compare th

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Gourav, Babriwal1* Rahul Meena2 Rashmi Mishra3 Radheshyam Vishvakarma4 Aarti Nandwana5 Rajat Pawar6. "Formulation And Evaluation of Ophthalmic in Situ Gel for Treatment of Fungal Keratitis." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 292–303. https://doi.org/10.5281/zenodo.15126830.

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The objective of this research was to formulate and evaluate the latent use of the in situ gel preparations for ocular delivery of posaconazole for the treatment of fungal keratitis. An in situ gelling system was used to rise the residence time and thus the bioavailability of posaconazole in ocular mucosa. In situ gel preparations were formulated by cold method using polymers like poloxamer 407, poloxamer 188 and sodium alginate. Finally, concentration of posaconazole in formulations was 0.2% (w/w). These formulations were evaluated for pH, solution-gel transition temperature, gelling capacity

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Bertram, Ulrike, Marie-Clotilde Bernard, Jean Haensler, Philippe Maincent, and Roland Bodmeier. "In situ gelling nasal inserts for influenza vaccine delivery." Drug Development and Industrial Pharmacy 36, no. 5 (2009): 581–93. http://dx.doi.org/10.3109/03639040903382673.

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Kao, Huei-Jen, Yu-Li Lo, Wen-Jong Vong, Yiu-Jiuan Lin, and Hong-Ru Lin. "Treating allergic conjunctivitis using in situ polyelectrolyte gelling systems." Journal of Biomaterials Science, Polymer Edition 17, no. 10 (2006): 1191–205. http://dx.doi.org/10.1163/156856206778530740.

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