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Journal articles on the topic 'In-situ patient monitoring'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Ko, Kathryn, and Scott Segan. "In Situ Hinge Craniectomy." Operative Neurosurgery 60, suppl_4 (2007): ONS—255—ONS—259. http://dx.doi.org/10.1227/01.neu.0000255380.64969.81.

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Abstract Objective: To describe an optional method for performing decompressive craniectomy using in situ hinge craniectomy technique in patients with traumatic brain injury and stroke. Methods: Sixteen patients underwent surgery for treatment of presenting pathology followed by the placement of hinge craniectomy. The technique is detailed. Results: Six patients with traumatic head injury and 10 with stroke underwent treatment of their primary pathologies with subsequent hinge craniectomy. Of these patients, more than half underwent refixation of the hinge in a minor procedure after recovery.

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Burkholder, Bryn M., and Irene C. Kuo. "Peripheral Ulcerative Keratitis following Laser in situ Keratomileusis." Case Reports in Ophthalmology 7, no. 1 (2016): 9–15. http://dx.doi.org/10.1159/000443324.

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Purpose: We report a case of a patient with a history of glomerulonephropathy, not disclosed prior to laser in situ keratomileusis (LASIK), who developed severe postoperative peripheral ulcerative keratitis (PUK) soon after surgery. Method: Case report. Results: Within a week of surgery, the patient, who had no blepharitis or ocular surface disease, also developed diffuse lamellar keratitis (DLK) that was not contiguous with the PUK. Microbiologic evaluation of the flap interface disclosed no organisms, and no epithelial ingrowth was found. Both PUK and DLK resolved with topical and oral stero

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Seong, DC, HM Kantarjian, JY Ro, et al. "Hypermetaphase fluorescence in situ hybridization for quantitative monitoring of Philadelphia chromosome-positive cells in patients with chronic myelogenous leukemia during treatment." Blood 86, no. 6 (1995): 2343–49. http://dx.doi.org/10.1182/blood.v86.6.2343.bloodjournal8662343.

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Using Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) as a model, our aim has been to develop a molecular cytogenetic method of high resolution analysis for monitoring the frequency of cells with nonrandom chromosome rearrangements in the bone marrow of patients receiving treatment for hematologic malignancies. Long-term exposure (24 hours) of bone marrow cultures to colcemid (0.1 microgram/mL) maximized a high frequency of metaphase collection. Such preparations were subjected to fluorescence in situ hybridization (FISH) using a 5 Mb probe that overlapped the region

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Qiu, Huiying, Yongquan Xue, Jinlan Jin, and De Pei Wu. "Fluorescence In Situ Hybridization Detected MRD and Chimerism in Patients with Hematologic Malignancies after allo-HSCT." Blood 106, no. 11 (2005): 5214. http://dx.doi.org/10.1182/blood.v106.11.5214.5214.

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Abstract Objective Monitoring of minimal residual disease (MRD) and cellular chimerism in patients with hematopoietic malignancies after allogeneic hematopoietic stem cell transplantation(allo-HSCT). Methods From May 2001 to June 2005, seventy four patients were received allo-HSCT. Including 50 Males and 24 females. 41 patients received sibling HLA-matched BMT, 7 patients received un-related BMT, 9 patients received Nonmyeloablative stem cell transplantation (NST), 14 patients received related haploidentical transplantation and 3 patients received allo-PBSCT. Among them, 45 patients were diagn

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Becker, Lucas, Felix Fischer, Julia L. Fleck, et al. "Data-Driven Identification of Biomarkers for In Situ Monitoring of Drug Treatment in Bladder Cancer Organoids." International Journal of Molecular Sciences 23, no. 13 (2022): 6956. http://dx.doi.org/10.3390/ijms23136956.

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Three-dimensional (3D) organoid culture recapitulating patient-specific histopathological and molecular diversity offers great promise for precision medicine in cancer. In this study, we established label-free imaging procedures, including Raman microspectroscopy (RMS) and fluorescence lifetime imaging microscopy (FLIM), for in situ cellular analysis and metabolic monitoring of drug treatment efficacy. Primary tumor and urine specimens were utilized to generate bladder cancer organoids, which were further treated with various concentrations of pharmaceutical agents relevant for the treatment o

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Uma, Hariharan, Sonowal Swaraj, and Kaur Mohandeep. "Pacemaker and Geriatric Anaesthesia: A special report." International Journal of Medical Reviews and Case Reports 3, no. 6 (2018): 331–33. https://doi.org/10.5455/IJMRCR.pacemaker-geriatric-anaesthesia.

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Geriatric medicine is a full-fledged speciality nowadays. Anaesthesia for geriatric patients is quite challenging. Elderly patients with serious cardiac problems are presenting for various surgeries, warranting the anaesthesiologist to formulate tailor-made peri-operative plan of management. We hereby present a case of an elderly male patient, posted for bilateral inguinal hernioplasty having a permanent pacemaker in situ in DDDR (dual-chamber rate-modulated) mode. The patient, on preoperative examination, was found to have a complete atrioventricular (AV) block on electrocardiogram (ECG) and

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Romero, Rodolfo, Lore Biliauws, Joel Roussel, and Jean-Marc Catheline. "Complications resulting from an intragastric balloon in a patient without follow-up and monitoring." BMJ Case Reports 17, no. 9 (2024): e258434. http://dx.doi.org/10.1136/bcr-2023-258434.

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The intragastric balloon (IGB) is recognised as a minimally invasive intervention for the treatment of obesity. Here, we detail a rare and life-threatening complication stemming from this procedure. A female patient in her 40s, who had an IGB in situ for 14 months, presented at the emergency department with septic shock characterised by abdominal guarding and emesis. These symptoms were a direct result of IGB-induced bowel obstruction. We emphasise that the patient missed the recommended 6-month removal window, which in our opinion is the decisive cause leading to deflated balloon migration an

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Shin, C. S., C. Y. Liu, and S. C. Hsu. "In Situ Fatigue Crack Initiation Monitoring in NiTi Rotary Endodontic Instruments." Advanced Materials Research 647 (January 2013): 3–8. http://dx.doi.org/10.4028/www.scientific.net/amr.647.3.

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During clinical operation in root canals, NiTi endodontic rotary instruments are subjected to alternating tension and compression and are prone to accidental fracture without prior warning. Once broken, extracting the fractured part from the canal is difficult and is annoying to both the patient and the dentist. Warning of an imminent fracture during clinical use will be a great help to avoid medical and legal complications. To this end, a monitoring technique that involves the picking up and analysis of the stress wave signals due to the cutting and rubbing at the canal wall-instrument blade

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Becker, Lucas, Nicole Janssen, Shannon L. Layland, et al. "Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring." Cancers 13, no. 22 (2021): 5682. http://dx.doi.org/10.3390/cancers13225682.

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Hurdles for effective tumor therapy are delayed detection and limited effectiveness of systemic drug therapies by patient-specific multidrug resistance. Non-invasive bioimaging tools such as fluorescence lifetime imaging microscopy (FLIM) and Raman-microspectroscopy have evolved over the last decade, providing the potential to be translated into clinics for early-stage disease detection, in vitro drug screening, and drug efficacy studies in personalized medicine. Accessing tissue- and cell-specific spectral signatures, Raman microspectroscopy has emerged as a diagnostic tool to identify precan

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Akram, Ahsan R., Sunay V. Chankeshwara, Emma Scholefield, et al. "In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A." Science Translational Medicine 10, no. 464 (2018): eaal0033. http://dx.doi.org/10.1126/scitranslmed.aal0033.

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Respiratory infections in mechanically ventilated patients caused by Gram-negative bacteria are a major cause of morbidity. Rapid and unequivocal determination of the presence, localization, and abundance of bacteria is critical for positive resolution of the infections and could be used for patient stratification and for monitoring treatment efficacy. Here, we developed an in situ approach to visualize Gram-negative bacterial species and cellular infiltrates in distal human lungs in real time. We used optical endomicroscopy to visualize a water-soluble optical imaging probe based on the antim

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Lynch, Thomas, Elizabeth S. Frank, Deborah E. Collyar, et al. "Comparing an operation to monitoring, with or without endocrine therapy (COMET), for low-risk ductal carcinoma in situ (DCIS)." Journal of Clinical Oncology 40, no. 16_suppl (2022): TPS616. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.tps616.

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TPS616 Background: Approximately 50,000 women in the U.S. are diagnosed with ductal carcinoma in situ (DCIS) each year. Without treatment, it is estimated that only 20-30% of DCIS will lead to invasive breast cancer (IBC). However, over 97% of women are currently treated with surgery +/- radiation. An alternative to surgery is active monitoring (AM), a management approach in which mammograms/physical exams are used to monitor breast changes and determine when, or if, surgery is needed. The COMET Study will compare risks and benefits of AM versus surgery for low-risk DCIS in the setting of a Ph

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Thakral, Ajay Kumar, Atul Aggarwal, Aamir Farooq, and Anklesh Sinha. "Successful laparoscopic cholecystectomy in a patient with ventriculoperitoneal shunt: a case report." International Surgery Journal 10, no. 8 (2023): 1406–8. http://dx.doi.org/10.18203/2349-2902.isj20232342.

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With advances in medical care there is a significant increase in life expectancy of patients with hydrocephalus. Many patients survive and live a meaningful life even after a decade of ventriculoperitoneal (VP) shunt placement. In this scenario, there are all the chances that these patients may need abdominal surgeries for pathologies unrelated to VP shunt. Laparoscopic cholecystectomy is one of the most common abdominal surgeries being performed. In patients with VP shunt in situ, before performing laparoscopic cholecystectomy factors such as type of shunt, shunt function, presence of shunt i

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Gu, Xinyi, Tao Yu, Tingting Guo, and Jian Kong. "A qPCR-based method for rapid quantification of six intestinal homeostasis-relevant bacterial genera in feces." Future Microbiology 16, no. 12 (2021): 895–906. http://dx.doi.org/10.2217/fmb-2020-0269.

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Aim: Developing efficient methods for monitoring the complex microbial community to rapidly assess the health status. Materials & methods: The qPCR-based method was developed, verified and in situ applied in fecal samples. Results: Six primer pairs with high specificity were designed to perform qPCR assays under a unified reaction condition within 2.5 h. The limits of detection, amplification efficiency and feasibility of the qPCR-based method established here were verified. In situ application of 18 fecal samples showed that the amounts of Bacteroides, Streptococcus and Bifidobacterium in

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Lynch, Thomas. "Abstract IA021: Challenges of conducting active surveillance for ductal carcinoma in situ (DCIS)." Cancer Prevention Research 15, no. 12_Supplement_1 (2022): IA021. http://dx.doi.org/10.1158/1940-6215.dcis22-ia021.

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Abstract The COMET (Comparing an Operation to Monitoring, with or without Endocrine Therapy) multicenter Phase III prospective trial randomizes women with low-risk DCIS to either standard of care (surgery +/- radiation therapy) or active surveillance (AS), a management approach in which mammograms and physical exams are used to monitor breast changes and determine when, or if, surgery is needed. It is currently open at 85 Alliance for Clinical Trials in Oncology sites and has accrued 905 patients as of 08/01/22. Initial recruitment challenges related to standardizing pathology eligibility crit

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Segall, Noa, Ron’Nisha Franklin, and Melanie C. Wright. "Cardiac Arrhythmia Simulations for Comparing Remote Telemetry Monitoring Systems." Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care 7, no. 1 (2018): 129–31. http://dx.doi.org/10.1177/2327857918071033.

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To increase the potential for timely detection of cardiac events, hospitalized patients who are at risk for critical arrhythmias are put on telemetry to continuously monitor their heart rhythm. However, telemetry monitoring systems vary widely between hospitals, there are few guidelines for decisions regarding optimal practices, and few studies have compared the efficiency of different monitoring systems. Our goal was to determine the impact of different monitoring systems on the time to detect and respond to critical cardiac events. To this end, we compared the process of communicating a crit

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Kałużewski, Tadeusz, Grzegorz K. Przybylski, Michał Bednarek, et al. "The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, RB1 and ERBB2 Somatic Mutations." Journal of Personalized Medicine 11, no. 5 (2021): 362. http://dx.doi.org/10.3390/jpm11050362.

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Bladder cancer is one of the most common cancers in global statistics. One of the issues associated with this disease is the high incidence of cases with delayed diagnosis and what factors correlate with worse treatment outcomes. A possible reason for this may be the rather limited availability of non-invasive diagnostic tools. This short communication presents a case of a 68 year old male patient after an ineffective therapy, carried on for several years with symptoms commonly associated with prostate overgrowth that masked a carcinoma in situ of the urinary bladder. Implementation of several

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Du, Xuan, Qifa Liu, Leshi Zhang, et al. "Identification of Acute Lymphocytic Leukemia Extramedullary Relapse and PTLD after Allo-HSCT by FISH Monitoring Sex Chromosome Chimeric Status." Blood 112, no. 11 (2008): 4311. http://dx.doi.org/10.1182/blood.v112.11.4311.4311.

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Abstract Objectives : To explore the role of fluorescence in situ hybridization (FISH) monitoring sex chromosome chimeric status in the identification of leukemic extramedullary relapse and post-transplant lymphoproliferative disease (PTLD) in acute lymphocytic leukemia (ALL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: Six ALL patients who received sex-mismatched allo-HSCT manifested extravisceral lymphadenectasis or local lump were investigated. The sex chromosome chimeric status in tumor tissues and bone marrow (BM) were monitored by FISH, and EBV-RNA in th

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Knapp, Karen M., Ann V. Rowlands, Joanne R. Welsman, and Kenneth M. MacLeod. "Prolonged Unilateral Disuse Osteopenia 14 Years Post External Fixator Removal: A Case History and Critical Review." Case Reports in Medicine 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/629020.

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Disuse osteopenia is a complication of immobilisation, with reversal generally noted upon remobilisation. This case report focuses on a patient who was seen 18 years following a road traffic collision when multiple fractures were sustained. The patient had an external fixator fitted for a tibia and fibula fracture, which remained in situ for a period of 4 years. Following removal, the patient was mobilised but, still required a single crutch to aid walking. Fourteen years post removal of the fixator, the patient had a DXA scan which, demonstrated a T-score 2.5 SD lower on the affected hip. Thi

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Kumari, Vanita, Devanshi Chowdhary, Bikash Ranjan Ray, and Poonam Joshi. "Mucormycosis an avoidable complication of COVID-19: a case report." International Journal Of Community Medicine And Public Health 8, no. 8 (2021): 4051. http://dx.doi.org/10.18203/2394-6040.ijcmph20213044.

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Mucormycosis is caused by the fungi belonging to the order Mucorales. There has been an increasing trend of rising fungal infection during the second wave of COVID in India, seen among patients recovering from COVID-19. A 37-years-old middle-aged adult, with the diagnosis of left paranasal sinus mucormycosis, left side pneumothorax (intercostal drainage tube in-situ) with COVID pneumonia reported to the emergency department (ED) during the COVID-19 pandemic in our hospital in India. The patient presented in the ED on oxygen support via a non-rebreathing mask at rate of 10 l/min with a history

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Ryser, Marc D., Samantha M. Thomas, Yan Li, et al. "Cancer outcomes in women without upfront surgery for ductal carcinoma in situ: observational cohort study." BMJ 390 (July 8, 2025): e083542. https://doi.org/10.1136/bmj-2024-083542.

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Abstract Objective To determine the risk of subsequent ipsilateral invasive breast cancer in women who do not receive upfront surgery on diagnosis of ductal carcinoma in situ (DCIS). Design Observational cohort study using data abstracted directly from patients’ medical records and from a national cancer registry in patients with primary DCIS diagnosed between 2008 and 2015. Setting Commission on Cancer accredited facilities (n=1330) in the US. Participants 1780 women with diagnosis of primary DCIS on needle biopsy who were alive and free of invasive breast cancer at 6 months after diagnosis.

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Mavrina, Elena S., Elena Parovichnikova, Vadim Surin, Julia R. Davidyan, and Valeri G. Savchenko. "Phenomenon of Oligoclonality in Adult Patients with Acute Lymphoblastic Leukemia." Blood 118, no. 21 (2011): 4895. http://dx.doi.org/10.1182/blood.v118.21.4895.4895.

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Abstract Abstract 4895 Introduction: Minimal residual disease (MRD) in adult patients with acute lymphoblastic leukemia (ALL) can be analyzed by flow cytometry, fluorescent in situ hybridization (FISH) if there are chromosomal abnormalities, polymerase chain reaction (PCR) for chimerical transcripts and immunoglobulin heavy chain (IgH) and T-cell receptor gamma (TCRG) genes rearrangements. IgH and TCRG rearrangements are the for monitoring of MRD, because it is possible to find specific clonal tumor marker in 80–90% patients. According to the data of different research groups phenomenon of oli

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Rajeev, P. B., M. Jyothiprasanth, C. R. Jithin, Mathew Abraham, S. C. Sarath, and Sijo Sebastian. "Metallosis and Severe Osteolysis Following Open Reduction and Internal Fixation Humerus Shaft Fracture: A Case Report and Literature Review." Journal of Orthopaedic Association of South Indian States 21, no. 2 (2024): 48–52. https://doi.org/10.4103/joasis.joasis_9_24.

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Abstract A 49-year-old male presented with right arm pain and was diagnosed with nonunion of the right humerus shaft, with a loosened implant in situ, 2 years and 3 months postoperatively. The patient had undergone open reduction and internal fixation with an eight-hole narrow dynamic compression plate made of titanium and two interfragmentary lag screws made of stainless steel following a road traffic accident. Subsequent investigations revealed severe osteolysis and metallosis, leading to the removal of the implant and wound debridement. After confirming the absence of infection, the patient

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Wang, Kui-Rong, Min Gao, Xiao-Hong Wen, and Hai-Ying Kong. "Anaesthetic management in endovascular total aortic arch repair via needle-based in situ fenestration: a case series of 14 patients." Journal of International Medical Research 48, no. 4 (2019): 030006051989351. http://dx.doi.org/10.1177/0300060519893517.

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Objective Endovascular total aortic arch repair (ETAAR) via needle-based in situ fenestration (ISF) is a major challenge for anaesthesiologists because of haemodynamic instability and the risk of cerebral hypoxia. We herein summarise our experience with anaesthetic management of patients who underwent this procedure. Methods Fourteen patients who underwent ETAAR via ISF for arch pathologies involving the major supra-arch branches were included. Regional cerebral oxygen saturation was measured to monitor cerebral perfusion. Partial extracorporeal circulation (EC) support from the right common f

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S P, Puneeth. "Review Paper on E-Smart Watch for Early Detection of Covid-19." International Journal for Research in Applied Science and Engineering Technology 9, no. VIII (2021): 363–66. http://dx.doi.org/10.22214/ijraset.2021.37335.

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Smart watches have the potential to support health in everyday living by: enabling self-monitoring of personal activity; obtaining feedback based on activity measures; allowing for in-situ surveys to identify patterns of behavior; and supporting bi-directional communication with health care providers and family members. However, smart watches are an emerging technology and research with these devices is at a nascent stage. Seventy-three studies were returned in the search. Seventeen studies published were included. Included studies were published from 2014 to 2016, with the exception of one pu

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Bromley, H. L., T. E. Roberts, D. Petrie, B. G. Mann, D. Rea, and C. Nickson. "Overcoming Overdiagnosis: Women´s Preferences for Improving Breast Cancer Screening." Journal of Global Oncology 4, Supplement 2 (2018): 38s. http://dx.doi.org/10.1200/jgo.18.50800.

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Background: Breast cancer screening is effective in reducing breast cancer mortality, but there is increasing concern that it may also lead to overdiagnosis; the detection and treatment of a cancer that would never have presented symptomatically during the woman's lifetime. Conservative management of low-risk breast cancer may reduce the harm of overdiagnosis resulting from mammographic screening programs, yet little is known about how such strategies might impact upon quality of life. Aim: To quantify women's preferences for managing low risk breast cancers identified by breast cancer screeni

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Jayachandran, Vijaya, and Nagaraja Puranik. "Study On the Levels of Inflammatory Markers in Venous Blood From Varicose Vein in-situ and from Peripheral Vein in Patients with Varicose Veins." Asian Journal of Medical Research & Health Sciences (A-JMRHS) 1, no. 1 (2025): 15. https://doi.org/10.5455/ajmrhs.20250504.

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Background/objectives: To evaluate the role, variations and correlate the inflammatory markers such as C-reactive Protein (CRP), Neutrophil to Lymphocyte ratio (NLR) and Erythrocyte Sedimentation Rate (ESR) as well as to analyze the changes in hematological parameters at the site of varicose veins (in-situ). Materials and methods: The study enrolled Thirty adult patients (both male and female, aged 18-64 years) with varicose veins. The study groups were divided into patients with varicose veins and a control group. Blood samples were collected from the antecubital vein of the control group and

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Curtis, Helen J., Peter Inglesby, Caroline E. Morton, et al. "Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY." British Journal of General Practice 72, no. 714 (2021): e51-e62. http://dx.doi.org/10.3399/bjgp.2021.0376.

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BackgroundOn 8 December 2020 NHS England administered the first COVID-19 vaccination.AimTo describe trends and variation in vaccine coverage in different clinical and demographic groups in the first 100 days of the vaccine rollout.Design and settingWith the approval of NHS England, a cohort study was conducted of 57.9 million patient records in general practice in England, in situ and within the infrastructure of the electronic health record software vendors EMIS and TPP using OpenSAFELY.MethodVaccine coverage across various subgroups of Joint Committee on Vaccination and Immunisation (JCVI) p

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Zheng, Hanjia, Amin GhavamiNejad, Peyman GhavamiNejad, Sarah Odinotski, and Mahla Poudineh. "(Invited) Micro-Enabled Technologies for Next-Generation Health Monitoring." ECS Meeting Abstracts MA2022-02, no. 61 (2022): 2221. http://dx.doi.org/10.1149/ma2022-02612221mtgabs.

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To enable personalized and precision medicine, it is crucial to monitor patient health status and bring information on disease-related agents and therapeutic drug molecules into the clinic. This requires new technologies to interrogate different body fluids that are rich sources of biomarkers, such as whole blood and interstitial fluid (ISF). Such technologies enable rapid, sensitive and - ultimately - real-time and continuous analysis of the clinically important biomarkers. Biophysics, materials chemistry and polymer and molecular engineering, as well as micro and nanofabrication, are crucial

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Szu, Harold, Charles Hsu, Gyu Moon, Joseph Landa, Hiroshi Nakajima, and Yutaka Hata. "Smartphone Homecare Monitoring of Hearts." Applied Computational Intelligence and Soft Computing 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/983515.

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Homecare monitoring blood pressures and heartbeats are commercially available using dedicated devices, for example, wrist watch, pulse oximetry. With the advent of Smartphone and compressive sensing technology, we wish to monitor precisely the electrical waveforms of heartbeats called the electrocardiography (ECG) for an aging global villager biomedical wellness homecare system. Our design separates into 3 innovative modules within the size-weight and power-cost bandwidth (Swap-CB) limitation. We develop each separately but in concert with one another: (i) Smart Electrode (adopting a low-power

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Sun, Xuemei, Junhao Chen, Pengjun Jiang, and Xuejun Zhu. "Phosphotyrosine Levels by Flow Cytometric Assay for Therapeutic evaluation in Chronic Myelogenous Leukemias." Blood 112, no. 11 (2008): 4246. http://dx.doi.org/10.1182/blood.v112.11.4246.4246.

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Abstract Assay of phosphotyrosine levels using flow cytometry has been used to identify patients with chronic myelogenous leukemia (CML) positive for the Bcr-Abl fusion gene. We hypothesized that clinical monitoring could identify treatment response through reductions in intra-granulocyte phosphotyrosine. Initially, we studied cell lines FDC-P1 and HL60 (Bcr-Abl–negative) and FDrv210 and K562 (Bcr-Abl–positive) with our technique. A fluorescein isothiocyanate-conjugated monoclonal antibody was used along with fluorescence-conjugated microspheres for reference (ratio of sample fluorescence: bea

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Adams, Elizabeth, Swati Kulkarni, Veronica Zheng, et al. "At-risk patient and healthcare provider perspectives on clinical trial participation for ductal carcinoma in situ." Journal of Clinical Oncology 40, no. 16_suppl (2022): 10539. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.10539.

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10539 Background: Significant challenges exist in recruiting newly diagnosed ductal carcinoma in situ (DCIS) patients to participate in presurgical intervention trials. Perceived motivators and barriers to participation have not been formally studied from the patient or healthcare provider (HCP) perspective. Based on our experience in the Promise Study (NCT02694809), we hypothesized that delaying surgery and concern for side effects are barriers to trial participation and that access to new treatments and financial benefits are motivators. To improve recruitment, we conducted focus groups to b

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Adams, Elizabeth, Swati Kulkarni, Veronica Zheng, et al. "At-risk patient and healthcare provider perspectives on clinical trial participation for ductal carcinoma in situ." Journal of Clinical Oncology 40, no. 16_suppl (2022): 10539. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.10539.

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10539 Background: Significant challenges exist in recruiting newly diagnosed ductal carcinoma in situ (DCIS) patients to participate in presurgical intervention trials. Perceived motivators and barriers to participation have not been formally studied from the patient or healthcare provider (HCP) perspective. Based on our experience in the Promise Study (NCT02694809), we hypothesized that delaying surgery and concern for side effects are barriers to trial participation and that access to new treatments and financial benefits are motivators. To improve recruitment, we conducted focus groups to b

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Pasche, Stéphanie, Silvia Angeloni, Réal Ischer, Martha Liley, Jean Luprano, and Guy Voirin. "Wearable Biosensors for Monitoring Wound Healing." Advances in Science and Technology 57 (September 2008): 80–87. http://dx.doi.org/10.4028/www.scientific.net/ast.57.80.

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Continuous health monitoring often requires hospitalization, which can become an expensive and inconvenient choice for the patient. In this perspective, wearable sensors that allow in situ biosensing constitute a very promising technology. This work aims to develop immunosensors for continuous monitoring of the wound healing process, based on pH changes, as well as on the concentrations of inflammatory proteins such as the C-reactive protein (CRP). Sensing principles include the use of responsive hydrogels that swell in response to changes in the surroundings, and the use of functional surface

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Chopra, Saurav, Timothy Dunham, Benjamin Darbro, and Carol J. Holman. "Utility of Flow Cytometry and Fluorescence in Situ Hybridization in Follow-up Monitoring of Multiple Myeloma." Blood 134, Supplement_1 (2019): 1880. http://dx.doi.org/10.1182/blood-2019-124411.

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Introduction Diagnosis and follow-up monitoring of Multiple Myeloma (MM) requires documentation of (clonal) plasma cells using morphological bone marrow assessment and other ancillary studies including CD138 immunohistochemistry (IHC), flow cytometry (FC), and myeloma-specific fluorescence in situ hybridization (FISH). While IHC and FC have traditionally been shown to be the more sensitive methods for the assessment of residual disease, the detection rates of FISH have markedly increased with the recent use of magnetic cell sorting for CD138 cell enrichment. We, therefore, aimed to revisit the

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Özen, Aydin, Stephan J. Linke, and Martin S. Spitzer. "An Enigmatic Fluid Accumulation Following Descemet Membrane Endothelial Keratoplasty After Prior Laser In Situ Keratomileusis." Cornea Open 3, no. 2 (2024): e0039. http://dx.doi.org/10.1097/coa.0000000000000039.

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Purpose: To report a case of interface fluid syndrome (IFS) following Descemet membrane endothelial keratoplasty (DMEK) 13 years after laser in situ keratomileusis (LASIK). Methods: A 79-year-old patient with bullous keratopathy underwent uneventful DMEK. Thirteen years prior, he had undergone LASIK. After DMEK, he developed an IFS, which was confirmed by a fluid accumulation in the flap interface, visible in the anterior segment optical coherence tomography (AS-OCT). In this case, IFS is presumed to have been triggered by the corticosteroid eye drops administered postoperatively. Measurements

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Gerstl, J. V. E., C. A. G. von Grothusen, J. L. Kilgallon, R. Lindberg, J. Onnela, and T. R. Smith. "P13.08.A JAKOB V. E. GERSTL, MBBS." Neuro-Oncology 25, Supplement_2 (2023): ii102. http://dx.doi.org/10.1093/neuonc/noad137.342.

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Abstract BACKGROUND Pituitary adenomas are benign neoplasms which can have a profound impact on quality of life. In-situ assessments of patient quality of life with pituitary adenomas and recovery from surgery are limited; existing patient reported outcome measures are, moreover, biased by patient recollection. Smartphone-based digital phenotyping may provide a means of monitoring patient recovery and quality of life at a more granular and accurate level. MATERIALS AND METHODS Patients with pituitary adenomas were enrolled during preoperative clinic visits. Included patients installed the Beiw

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Williams, Ryan M., Pooja Vinod Gaikwad, Amelia K. Ryan, et al. "(Invited) Near-Infrared Photoluminescent Nanosensors for In Vivo Pharmacology and Inflammation Monitoring." ECS Meeting Abstracts MA2023-01, no. 9 (2023): 1122. http://dx.doi.org/10.1149/ma2023-0191122mtgabs.

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Rapid, minimally-invasive in situ detection of analytes in vivo remains a goal to study inflammatory signaling molecules and pharmacology of therapeutics. Towards this end, we are using the near-infrared photoluminescent properties of single-walled carbon nanotubes (SWCNT) to design sensors for use in live mice. The photostable, environmental-responsive, tissue-transparent emission of SWCNT is ideal for this application. Therefore, we are working toward in vivo analyte monitoring through a simple injection of hydrogel-encapsulated SWCNT sensors to localize signal to specific sites in the body.

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Gandhi, Sirin, Justin R. Mascitelli, Claudio Cavallo, Ali Tayebi Meybodi, and Michael T. Lawton. "Far Lateral Craniotomy and Occlusion In Situ of a Lateral Medullary Arteriovenous Malformation: 2-Dimensional Operative Video." Operative Neurosurgery 19, no. 4 (2020): E423. http://dx.doi.org/10.1093/ons/opaa092.

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Abstract Lateral medullary arteriovenous malformations (AVMs) are located in the pia on the lateral medullary surface.1 They are supplied by arterial feeders from the V4 segment of the vertebral artery or posterior inferior cerebellar artery. A 64-yr-old man presented with leg spasms and progressively worsening gait. Angiography demonstrated a lateral medullary AVM. Patient consent was obtained for the surgical treatment of this lesion. Owing to its eloquent location, an occlusion in situ was performed without resection.1,2 This technique relies on the interruption of the arterial blood supply

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Li, Yi Hong, Yen-Chuan Ou, Min Che Tung, et al. "Gender disparities in bladder cancer: A population-based study on life expectancy and health spending in Asia." PLOS One 20, no. 6 (2025): e0323803. https://doi.org/10.1371/journal.pone.0323803.

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Background The aim of this study was to elucidate the disparities in life expectancy, loss-of-life expectancy, and lifetime medical expenditure between sexes in patients with bladder cancer. Methods In this retrospective study, we used three Taiwanese databases to analyze the data of patients diagnosed with bladder cancer between 2008 and 2019. Patients aged <30 years or >90 years were excluded. Survival and lifetime costs were estimated using the Kaplan–Meier and semiparametric methods. Subgroup analyses were performed to examine the effects of cancer stage, age, and factors such as hem

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Bunea, Alina-Cristina, Violeta Dediu, Edwin Alexandru Laszlo, et al. "E-Skin: The Dawn of a New Era of On-Body Monitoring Systems." Micromachines 12, no. 9 (2021): 1091. http://dx.doi.org/10.3390/mi12091091.

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Real-time “on-body” monitoring of human physiological signals through wearable systems developed on flexible substrates (e-skin) is the next target in human health control and prevention, while an alternative to bulky diagnostic devices routinely used in clinics. The present work summarizes the recent trends in the development of e-skin systems. Firstly, we revised the material development for e-skin systems. Secondly, aspects related to fabrication techniques were presented. Next, the main applications of e-skin systems in monitoring, such as temperature, pulse, and other bio-electric signals

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Seong, Chy-Myong, Sergio Giralt, Hagop Kantarjian, et al. "Early Detection of Relapse by Hypermetaphase Fluorescence In Situ Hybridization After Allogeneic Bone Marrow Transplantation for Chronic Myeloid Leukemia." Journal of Clinical Oncology 18, no. 9 (2000): 1831–36. http://dx.doi.org/10.1200/jco.2000.18.9.1831.

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PURPOSE: Standard G-band cytogenetic analysis (CG) provides information on approximately 25 metaphases for monitoring the presence of Philadelphia chromosome positive (Ph+) cells in chronic myelogenous leukemia (CML) patients, making the detection of a low frequency of Ph+ cells problematic. The purpose of this study was to improve the detection of a low frequency of Ph+ cells. PATIENTS AND METHODS: We combined fluorescence in situ hybridization (FISH) with long-term colcemid exposure, capturing several hundred metaphases in bone marrow cultures (hypermetaphase FISH [HMF]). Using probes that i

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Poudineh, Mahla. "(Invited) Next-Generation Enabling Technologies for Disease Diagnosis and Therapeutic Monitoring." ECS Meeting Abstracts MA2023-01, no. 53 (2023): 2646. http://dx.doi.org/10.1149/ma2023-01532646mtgabs.

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To enable personalized and precision medicine, it is crucial to monitor patient health status and bring information on disease-related agents and therapeutic drug molecules into the clinic. This requires new technologies to interrogate different body fluids that are rich sources of biomarkers, such as whole blood and interstitial fluid (ISF). Such technologies enable rapid, sensitive and - ultimately - real-time and continuous analysis of the clinically important biomarkers. Micro and nanofabrication and nanomaterials as well as materials chemistry and polymer and molecular engineering are cru

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Mishra, Deepak Kumar, Indranil Dey, Rakesh Demde, Sushant Vinarkar, and Mayur Parihar. "Disease Response Assessment Modalities in Chronic Myeloid Leukemia: Past, Present, and Future." Indian Journal of Medical and Paediatric Oncology 44, no. 06 (2023): 592–601. http://dx.doi.org/10.1055/s-0043-1771186.

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AbstractChronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by the BCR::ABL1 fusion gene, which results from a reciprocal translocation between chromosome 9 and 22 t(9;22)(q34;q11). The use of tyrosine kinase inhibitor (TKI) against the chimeric BCR::ABL1 fusion protein has led to a paradigm shift in CML patient outcomes. Despite generational advancements in TKI, a fraction of patients harbor residual disease or exhibit resistance to TKI. The importance of disease monitoring and detection of resistance mechanisms has gained prominence with increasing knowledge about disease

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Fischer, Julie, and Luis Rohena. "Novel Phenotype in Unbalanced 7;9 Translocation with Critical Incidental Finding." Case Reports in Genetics 2022 (May 17, 2022): 1–5. http://dx.doi.org/10.1155/2022/7510079.

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This case discusses a now 13-year-old boy who underwent chromosome analysis and fluorescence in situ hybridization (FISH) for subtelomeric rearrangements due to dysmorphic features at birth. This testing revealed a diagnosis of an unbalanced 7;9 translocation resulting in monosomy for 7q34-qter and trisomy for 9pter-p21, which resulted in a very complex medical course. At the age of 12, due to persistent complex neurodevelopmental concerns, the patient was referred by neurology for whole-exome sequencing. This testing revealed an incidental pathogenic heterozygous KCNH2 deletion, which is asso

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Nagy, Dea, Eric Tucker, Samatha Rajkovich, et al. "Multiplexed protein and gene profiling of circulating tumor cells (CTCs) in metastatic castration-resistant prostate cancer (mCRPC) using automated immunofluorescence and fluorescence in situ hybridization." Journal of Clinical Oncology 31, no. 6_suppl (2013): 158. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.158.

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158 Background: Clinically, CTCs are used primarily in longitudinal monitoring of metastatic disease progression. However, the analysis of specific CTC biomarkers has the potential to optimize patient management by identifying those likely to respond to specific targeted agents. Often, mCRPC is driven by dysregulation of the androgen receptor (AR) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) oncogenic pathways such that blockade of one pathway stimulates the other. These functional deficits in the AR and PI3K/AKT pathways are associated with fusion of the TMPRSS2 and ERG genes

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Mukherjee, Tanushri, Soma Mukherjee, and Rajat Dutta. "Molecular diagnosis of pediatric tumors." International Journal of Molecular and Immuno Oncology 2, no. 2 (2017): 33. http://dx.doi.org/10.18203/issn.2456-3994.intjmolimmunooncol20172638.

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<p>Pediatric tumors are challenging in the context of best diagnosis, treatment, and prognosis. For tumors which have a genetic association or a cancer predisposition syndrome, the prognosis depends on accurate diagnosis. The application of molecular genetics to pediatric tumors has resulted in better diagnostic and prognostic factors for patient management. Molecular diagnostic techniques, such as reverse transcription polymerase chain reaction and fluorescence in situ hybridization (FISH), have become important tests for childhood tumors. Targeted therapies are aimed at specific transl

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Wark, Landon, Harvey Quon, Aldrich Ong, Darrel Drachenberg, Aline Rangel-Pozzo, and Sabine Mai. "Long-Term Dynamics of Three Dimensional Telomere Profiles in Circulating Tumor Cells in High-Risk Prostate Cancer Patients Undergoing Androgen-Deprivation and Radiation Therapy." Cancers 11, no. 8 (2019): 1165. http://dx.doi.org/10.3390/cancers11081165.

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Patient-specific assessment, disease monitoring, and the development of an accurate early surrogate of the therapeutic efficacy of locally advanced prostate cancer still remain a clinical challenge. Contrary to prostate biopsies, circulating tumor cell (CTC) collection from blood is a less-invasive method and has potential as a real-time liquid biopsy and as a surrogate marker for treatment efficacy. In this study, we used size-based filtration to isolate CTCs from the blood of 100 prostate cancer patients with high-risk localized disease. CTCs from five time points: +0, +2, +6, +12 and +24 mo

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Mac Grory, Brian, Sean R. Landman, Paul D. Ziegler, et al. "Detection of Atrial Fibrillation After Central Retinal Artery Occlusion." Stroke 52, no. 9 (2021): 2773–81. http://dx.doi.org/10.1161/strokeaha.120.033934.

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Background: Central retinal artery occlusion (CRAO) causes sudden, irreversible blindness and is a form of acute ischemic stroke. In this study, we sought to determine the proportion of patients in whom atrial fibrillation (AF) is detected by extended cardiac monitoring after CRAO. Methods: We performed a retrospective, observational cohort study using data from the Optum deidentified electronic health record of 30.8 million people cross-referenced with the Medtronic CareLink database of 2.7 million people with cardiac monitoring devices in situ. We enrolled patients in 3 groups: (1) CRAO, (2)

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Kim, Miyoung, Song-yee Kim, Cha Ja She, et al. "Circulating Malignant Clonal Cells in Peripheral Blood of Patients with Myelodysplastic Syndrome: Verification by Interphase Fluorescent in Situ Hybridization Study and Its Correlation with Bone Marrow Clonal Cells." Blood 114, no. 22 (2009): 4840. http://dx.doi.org/10.1182/blood.v114.22.4840.4840.

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Abstract Abstract 4840 Introduction Bone marrow (BM) cells are believed as the source neoplastic cells in patients with myelodysplastic syndrome (MDS). We examined whether the clonal proliferating pattern in peripheral blood truly reflects clonal haemopoiesis in the bone marrow. Materials and Methods We performed interphase fluorescence in situ hybridization (iFISH) with peripheral blood mononuclear cells in MDS patients with clonal abnormalities detected using iFISH and conventional G-banding. Nine patients were included in the study: 3 at initial diagnosis (patient 4, 6 and 9), 2 at follow u

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Anderson, K., R. Wilkinson, and M. H. Grant. "Assessment of Liver Function in Primary Cultures of Hepatocytes Using Diethoxy (5,6) Chloromethylfluorescein and Confocal Laser Scanning Microscopy." International Journal of Artificial Organs 21, no. 6 (1998): 360–64. http://dx.doi.org/10.1177/039139889802100602.

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A method is presented which can be used to assess the function of hepatocytes in complex culture configurations without disrupting the integrity of the cell environment. It utilises a fluorescent probe for cytochrome P450 dependent mixed function oxidase (MFO) activity, diethoxy (5,6) chloromethylfluorescein, and confocal laser scanning microscopy. The MFO activity of individual cells in primary cultures of intact hepatocytes can be detected in situ, and quantified by image analysis. This may be a valuable means of monitoring the effect of culture conditions on the function of bioartificial li

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