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Dissertations / Theses on the topic 'In vitro biological evaluation'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

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1

Anissian, H. Lucas. "In vitro evaluation of hip prostheses /." Stockholm, 2001. http://diss.kib.ki.se/2001/20010420anis/.

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2

Ørskov, Christensen Janne. "Evaluation of an in vitro lipid digestion model : testing poorly soluble drug substances and lipid-based formulations /." [Cph.] : Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/jannechristensen.htm.

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3

Poggialini, Federica. "Investigation of in vitro and in vivo pharmacokinetics and biological evaluation of pharmacologically active compounds." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1202964.

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The first part of this thesis deals with the evaluation of in vitro and in vivo pharmacokinetics of novel broad-spectrum antiviral compounds active against enveloped viruses. The design and synthesis of new series of antiviral compounds with 1H-pyrrol-methylene thioxodihydropyrimidine structure, has been realized by Professor Maurizio Botta's research group, at the University of Siena. Compounds’ antiviral activity has been evaluated on several enveloped viruses, such as ZIKAV, DENV-2 and five influenza strains including the pandemic strain H7N9. The selectivity against enveloped viruses, time

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4

Machado, Michel Mansur. "Perfil fitoquímico e avaliação dos principais efeitos biológicos e imunológicos In Vitro da Euphorbia tirucalli L." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/5893.

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Today we can easily find the most diverse kind of information about a particular medicinal plant, but without scientific basis, making their use a potential risk to health. Overall, the findings on the safety and efficacy are based on precarious evaluations and popular use. There is a need for qualified professionals to access, critical analyze and assign such information in a way that it could be easily understood, not only by health professionals, but also by the users of these products. One example of these plants used in popular medicine, but without scientific evidence, is Euphorbia tiruc

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5

Bwalya, A. G. "Evaluation of the in vitro biological activities and phytochemical profiling of eight Ficus species collected in Zambia." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1457111/.

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Infectious diseases are responsible for an overwhelming number of deaths and morbidity worldwide. In tropical regions of the world, in particular, developing countries like Zambia, poor health is prevalent and diseases such as malaria, meningitis, pneumonia, tuberculosis and gastrointestinal infections strongly persist. Folkloric medicines are still actively used against some of these infections as primary care before seeking conventional treatment at hospitals. Members of the genus Ficus (Moraceae) are traditionally used in Zambia against many diseases caused by bacterial, fungal and protozoa

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6

PRENCIPE, Filippo. "Synthesis and biological evaluation in vitro and in vivo of novel potent anticancer agents affecting tubulin polymerization." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2487939.

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L’attività di ricerca svolta durante i tre anni di dottorato ha avuto come obiettivo la progettazione, la sintesi e l’ottimizzazione di nuovi potenziali agenti antitumorali dotati di attività antiproliferativa e antivascolare che hanno come target biologico i microtubuli, strutture dinamiche cellulari generate dalla polimerizzazione di eterodimeri di α,β tubulina. Il sistema di microtubuli è essenziale per la divisione cellulare, essendo coinvolto nella formazione del fuso mitotico, ed è importante per diversi processi cellulari quali la regolazione della motilità, segnalazione cellulare, secr

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7

Galgano, Camillo. "Evaluation des propriétés biologiques et de scellement de 4 matériaux endodontiques = [In vitro evaluation of the biological and sealing properties of four endodontic sealers] /." Genève : [s.n.], 2005. http://www.unige.ch/cyberdocuments/theses2005/GalganoC/these.pdf.

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8

Hollywood, Jane Constance. "Biological control of late blight of potatoes : in vivo and in vitro evaluation of microbial antagonists against tuber blight." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446592/.

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The cost of losses and control measures attributed to late blight of potatoes caused by Phytophthora infestans, are estimated to exceed $5 billion annually. Breeding for resistance is difficult owing to the tetraploid genotype of potato and current strains of the pathogen have developed resistance to chemical control. Consequently the search for biological control has assumed greater importance. In this investigation an in vivo bioassay was used to select soils antagonistic to late blight of potatoes, caused by Phytophthora infestans. Four out of eight samples demonstrated reproducible antagon

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9

Blanco, Carcache Peter Josephin. "Chemical Characterization and Biological Evaluation of Secondary Metabolites Isolated from Glycosmis ovoidea." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1580383951030389.

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10

Lolato, A. "FROM BENCH TO CHAIRSIDE: EVALUATION OF BIOLOGICAL EFFECTS OF PLATELET CONCENTRATES THROUGH AN IN-VITRO STUDY AND A RANDOMIZED CLINICAL TRIAL." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/474332.

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Autologous platelet concentrates are widely used in a variety of medical application with the aim of enhancing the regeneration of hard and soft tissue. The rationale of this clinical use lies in their enriched content of growth factors and other key molecules involved in promoting tissue healing. This thesis is composed of two different studies having as a common objective the evaluation of the biological properties of a platelet concentrate, Pure-Platelet Rich Plasma. The first part of the thesis was a pre-clinical in vitro study focused on evaluating the stimulating activity of P-PRP on

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11

Bossy, Emmanuel. "Evaluation ultrasonore de l'os cortical par transmission axiale : modélisation et expérimentation in vitro et in vivo." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2003. http://tel.archives-ouvertes.fr/tel-00003220.

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La technique dite de transmission axiale permet une évaluation ultrasonore de l'os cortical, à partir d'une mesure de vitesse. Cette technique est étudiée dans la présente thèse d'une part en modélisant par simulation numérique les phénomènes de propagation mis en jeu, d'autre part à travers une approche expérimentale. Un code de simulation de la propagation tridimensionnelle dans les milieux élastiques anisotropes et hétérogènes, reposant sur un schéma aux différences finies, a été implémenté pour répondre aux contraintes spécifiques de la propagation dans l'os cortical. A l'aide d'un tel cod

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12

Moret, Francesca. "Nanovehicles for medical use: an in vitro evaluation of cytotoxicity and drug delivery efficiency." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423637.

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The recent progresses offered by nanotechnology in the manipulation of matter lead to the development of several nanoparticles (NPs) and nanodevices for medical applications. In oncology, nanosized objects are particularly attractive as drug delivery systems since it is expected that engineered nanovehicles of appropriate size and functionalised with specific ligands/antibodies will improve the efficacy and selectivity of cancer therapies by exploiting both the passive and active mechanism of tumour targeting. The use of delivery systems is particularly appealing in those therapies in which th

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13

Schoutteten, Laetitia. "Photophysique et photochimie du calcium green in vitro et ex vivo." Cachan, Ecole normale supérieure, 1997. http://www.theses.fr/1997DENS0022.

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LLa photophysique du calcium green a été étudiée grâce au montage de fluorescence résolue en temps sous microscope. Cette sonde est caractérisée par des durées de vie différentes selon l'état de complexation au calcium. Elle n'est pas sensible a la viscosité et peu sensible a la polarité, mais sensible a l'hydrolyse, a l'adsorption et au ph. La molécule sonde le milieu dans son état fondamental. Il existe deux conformations stables de la sonde, caractérisées par leurs durées de vie. La durée de vie courte est due au transfert de charges intramoléculaire. Des études ex vivo sur des cellules ont

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14

Moniot, Aurélie. "Etude des effets anti-inflammatoires et anti-cancéreux de nouvelles molécules agrosourcées à motif pyridazinone Synthesis and biological evaluation of pyridazinone derivatives as potential antiinflammatory agents Osteoinductive Material to Fine-Tune Paracrine Crosstalk of Mesenchymal Stem Cells With Endothelial Cells and Osteoblasts." Thesis, Reims, 2020. http://www.theses.fr/2020REIMS022.

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L’ostéosarcome est un cancer primitif rare de l’os dont les approches thérapeutiques actuelles sont encore malheureusement insuffisantes pour espérer une totale guérison, et pour lequel la recherche de nouvelles molécules efficaces est constante. De plus, après exérèse de la tumeur, le défaut généré peut nécessiter de recourir à des matériaux aidant la reconstruction osseuse. Or le potentiel inflammatoire de ces matériaux est bien documenté. Les inhibiteurs de phosphodiestérase de type 4, parmi lesquels des molécules à motif pyridazinone, ont d’ores et déjà fait leurs preuves en tant qu’agents

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15

Maurer, Christine Katharina [Verfasser], and Rolf W. [Akademischer Betreuer] Hartmann. "From in vitro to in vivo : establishment of a test system for the biological evaluation of novel quorum sensing inhibitors as anti-infectives against Pseudomonas aeruginosa / Christine Katharina Maurer. Betreuer: Rolf W. Hartmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/107519038X/34.

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16

Vasanthi, Bathrinarayanan Pranav. "Evaluating the biological effects of electronic cigarettes using a novel in-house designed aerosol delivery system and an in-vitro co-culture model of the human airways." Thesis, Aston University, 2018. http://publications.aston.ac.uk/37691/.

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Although electronic cigarettes (ECs) have been widely promoted as safer alternatives to tobacco cigarettes, limited scientific data is currently available on their possible health effects. The current study aims to investigate the potential effects of ECs using a novel in-house designed cigarette/EC aerosol delivery system and physiologically relevant 2D and 3D in-vitro human airway models. Submerged cultures of BEAS 2B and CALU 3 bronchial epithelial cells were used to investigate the effects of nicotine and its oxidative metabolite cotinine. Results demonstrated that neither nicotine nor cot

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17

Andrade, Lilian Cristina Morais de. "Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/5874.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-09T12:17:35Z No. of bitstreams: 2 Dissertação - Lilian Cristina Morais de Andrade - 2013.pdf: 1070622 bytes, checksum: c44e7d6decc4c88ffa0d3bbacd190bc6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-09T12:19:51Z (GMT) No. of bitstreams: 2 Dissertação - Lilian Cristina Morais de Andrade - 2013.pdf: 1070622 bytes, checksum: c44e7d6decc4c88ffa0d3bbacd190bc6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ec

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18

M'Bengue, Marie-Stella. "Conception et évaluation d'une endoprothèse vasculaire par impression 3D pour le traitement des anévrismes complexes de l'aorte abdominale." Electronic Thesis or Diss., Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILS057.

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La réparation endovasculaire (EVAR) d'un anévrisme de l'aorte abdominale (AAA) consiste en la mise en place d'une endoprothèse (EDP) par chirurgie mini-invasive au sein de l'anévrisme. Cet acte permet de prévenir la rupture des tissus endommagés impliqués dans un AAA, défini comme la dilatation localisée du diamètre de l'aorte. Lorsque l'amont de l'anévrisme englobe les artères périphériques rénales et/ou viscérales, l'AAA est qualifié de complexe. Dans ce cas, l'EDP déployée est dite « fenêtrée », en d'autres termes, perforée à l'emplacement des jonctions vers les artères périphériques. La pr

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19

MORENO, CAROLINA dos S. "Avaliação dos efeitos da radiação ionizante e do Resveratrol na cultura de células tumorais de pulmão." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26829.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-11-11T17:21:57Z No. of bitstreams: 0<br>Made available in DSpace on 2016-11-11T17:21:57Z (GMT). No. of bitstreams: 0<br>O carcinoma mucoepidermóide de pulmão, um tipo histológico que deriva das glândulas mucosas traqueobrônquicas, manifesta-se com sintomas obstrutivos e tende a comprometer a traqueia. Com finalidade curativa ou paliativa da doença, atualmente há uma forte tendência na oncologia em desenvolver estratégias terapêuticas que visam à administração de compostos com elevado potencial de otimizar o efeito do tratamento com

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20

Sansook, Supojjanee. "Biological evaluation of ferrocene derivatives." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/68599/.

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Organometallic complexes containing transition metals, such as Ru(II), Os(II), Ir(III), have been moderately and recently used in medicinal chemistry as anticancer, antimalarial, antimicrobial or diagnostic agents. Current trends have led researchers to explore and define new synthetic methods in the quest for the design of new drugs and reduce the inherit associated toxic side-effects by using metal based compounds. Ferrocene based derivatives have been subjected to study for their biological and medicinal applications. Examples include ferrocenophane polyphenol, ferrocenyl quinone methides,

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21

Abel, Stuart Michael. "Cortisol metabolism in vitro : biological and structural determinants." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357368.

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22

Loh, Vincent M. "Aminophosphinic acids : construction and biological evaluation." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243474.

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23

Mulqueen, Gerard C. "Siderphores : design, synthesis, and biological evaluation." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358061.

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24

Holmes, Jan L. "Development of functional in vitro toxicity tests." Thesis, Aston University, 1998. http://publications.aston.ac.uk/10976/.

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In vitro toxicity tests which detect evidence of the formation of reactive metabolites have previously relied upon cell death as a toxicity end point. Therefore these tests determine cytotoxicity in terms of quantitative changes in specified cell functions. In the studies involving the CaCO-2 cell model, there was no significant change in the transport of [3H] l-proJine by the cell after co-incubation with either dapsone or cyclophosphamide (50!!M) and rat liver microsomal metabolite generating system. The pre incubation of the cells with N-ethylmalemide to inhibit Phase II sulphotransferase a

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25

Samiullah, Ph D. "Synthesis, functionalisation and biological evaluation of tetrahydroxanthones." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/47038/.

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This thesis describes the development of new methods for the synthesis of mono-, diand trihydroxylated tetrahydroxanthones which are structural elements of a range of important natural products including the anti-cancer agents known as the kigamicins. In Chapter One, work on the isolation, biological significance and chemical synthesis of xanthones, dihydroxanthones, and tetrahydroxanthones is reviewed, with special focus on the polycyclic tetrahydroxanthone natural products. Chapter Two describes the development of methods for the synthesis of tetrahydroxanthones mimicking the ABC rings of ki

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26

Rached, Ouannassa. "Biological evaluation of aziridine-based SAM analogues." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546288.

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27

Lim, Ze-Yi. "Synthesis and biological evaluation of phosphoinositide analogues." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620205.

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28

Baloglu, Erkan. "Synthesis and Biological Evaluation of Paclitaxel Analogs." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/27853.

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The complex natural product paclitaxel (TaxolÂ®), first isolated from Taxus brevifolia, is a member of a large family of taxane diterpenoids. Paclitaxel is extensively used for the treatment of solid tumors, particularly those of the breasts and ovaries. In order to obtain additional information about the mechanism of action of paclitaxel and the environment of the paclitaxel-binding site, several fluorescent analogs of paclitaxel were synthesized, and their biological activities have been evaluated. For the investigation of possible synergistic effects, concurrent modifications on sele

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29

Barney, Rocky James. "Synthesis and biological evaluation of novel phosphonates." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/778.

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Phosphonates represent an important class of organophosphorus compounds. Their use as reagents in organic synthesis is prevalent, and there is a plethora of examples of biologically active compounds possessing the phosphonate moiety. To further our exploration of phosphonates as both reagents and biologically active compounds we have developed a one-flask protocol for the direct synthesis of phosphonates from benzylic and allylic alcohols. This transformation is unprecedented and is applicable to a range of substrates. Both electron rich and electron deficient benzylic alcohols react under the

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30

Garside, John R. "Differential phase confocal microscopy of live biological samples in-vitro." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362893.

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31

Guermazi, Mahdi. "In-Vitro Biological Tissue State Monitoring based on Impedance Spectroscopy." Doctoral thesis, Universitätsverlag der Technischen Universität Chemnitz, 2016. https://monarch.qucosa.de/id/qucosa%3A20484.

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The relationship between post-mortem state and changes of biological tissue impedance has been investigated to serve as a basis for developing an in-vitro measurement method for monitoring the freshness of meat. The main challenges thereby are the reproducible measurement of the impedance of biological tissues and the classification method of their type and state. In order to realize reproducible tissue bio-impedance measurements, a suitable sensor taking into account the anisotropy of the biological tissue has been developed. It consists of cylindrical penetrating multi electrodes realizing

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Guermazi, Mahdi. "In-Vitro Biological Tissue State Monitoring based on Impedance Spectroscopy." Doctoral thesis, Universitätsbibliothek Chemnitz, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-206710.

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The relationship between post-mortem state and changes of biological tissue impedance has been investigated to serve as a basis for developing an in-vitro measurement method for monitoring the freshness of meat. The main challenges thereby are the reproducible measurement of the impedance of biological tissues and the classification method of their type and state. In order to realize reproducible tissue bio-impedance measurements, a suitable sensor taking into account the anisotropy of the biological tissue has been developed. It consists of cylindrical penetrating multi electrodes realizing g

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33

Purdon, Carryn Hamilton. "In vitro passage of ibuprofen through synthetic and biological membranes." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1003264.

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Ibuprofen is a non-steroidal anti-inflammatory drug with three major types of effect: anti-inflammatory, analgesic and antipyretic. Ibuprofen may be administered in a number of different forms via the oral as well as the topical route. Published evidence suggests that topical, unlike oral, non-steroidal anti-inflammatory drugs are associated with few systemic side effects as plasma concentrations are low compared to oral therapy. In some countries it is particularly difficult to obtain human skin for in vitro experimentation and it is therefore important to have alternate biological or synthet

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34

MOSCHINI, ELISA. "Nanoparticles: biological effects on in vitro and in vivo systems." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/29889.

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The advent of nanotechnology and the commercialization of several nanoparticle-containing products call to a serious assessment of the environmental and human risks derived from the exposure to these new materials. The emerging properties, the increasing world market and the several exposure scenarios are some of the main criticisms related to distribution of these products. Among nanomaterials metal oxides nanoparticles are considered at the same time an interesting and critical group; in particular titanium dioxide, zinc oxide and cupric oxide (nTiO2, nZnO, nCuO) have received particular at

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35

Hills, Daniel Richard. "In vitro characterisation of biological activity of novel nitric oxide donor compounds." Thesis, Kingston University, 2017. http://eprints.kingston.ac.uk/40673/.

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Nitric oxide (NO), being a free radical, has a unique biological chemistry that, since its elucidation as a signaling molecule in the cardiovascular system, has been implicated in a range of diverse biological functions. Both cardiovascular disease, exacerbated by hypertension, and antibiotic-resistant bacterial infections are major yet unavoidable public health concerns. Atypical NO synthesis may be a factor these pathologies and exogenous NO may provide an alternative therapeutic strategy when endogenous NO synthesis is atypically low. Furoxans are an old, yet largely untapped resource of ni

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36

Patel, Ramila. "Delivery and stability of antisense oligonucleotide conjugates in vitro." Thesis, Aston University, 1998. http://publications.aston.ac.uk/10983/.

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The aim of this project was to study the delivery of ODNs to macrophages and to assess the stability of two ODN conjugates, in vitro. The first conjugate aimed to improve uptake of ODNs via mannose receptor mediated delivery, the second investigated the improved delivery of ODN conjugates via non-specific lipophilic interaction with the cell membrane. A mono-mannose phosphoramidite derivative was designed and synthesised and a mono-mannose ODN conjugate synthesised by standard phosphoramidite chemistry. Delivery of this conjugate was enhanced to RAW264.7 and J774 macrophage cell lines via a me

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Wu, Lianpao. "Synthesis and Biological Evaluation of New Tetrahydrobenzothiophene Derivatives." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60470.

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38

Kashiwazaki, Gengo. "Design and Biological Evaluation of PI Polyamide Conjugates." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157796.

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Mendoza, Sánchez Rodrigo. "Design, synthesis, and biological evaluation of novel antiestrogens." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117025.

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Breast cancer is the most common form of cancer in women in the Western world and the second most fatal after lung cancer. Estrogens play a crucial role in normal breast development, but also contribute to mammary tumorigenesis. Estrogen signaling is mediated by intracellular estrogen receptors (ERα and ERβ), with ERα being a common target in breast cancer therapeutics. Two classes of competitive estrogen inhibitors have been investigated and proved to be useful for breast cancer treatment: full antiestrogens (FAE's) and selective estrogen receptor modulators (SERM's). A novel platform, FORECA

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40

Stewart, Lee Robert. "The synthesis and biological evaluation of 4-azafluorenones." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366936.

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41

MENES, ALEJANDRO MUSTELIER. "QUALITY EVALUATION FOR FRAGMENTS ASSEMBLY OF BIOLOGICAL SEQUENCES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2017. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=33967@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>PROGRAMA DE EXCELENCIA ACADEMICA<br>Nos últimos anos surgiram novas tecnologias de sequenciamento de DNA conhecidas como NGS - Next-Generation Sequencing. Estas são responsáveis por tornar o processo de sequenciamento mais rápido e menos custoso, mas também trazem como resultado fragmentos de DNA muito pequenos, conhecidos como reads. A montagem do genoma a partir destes fragmentos é considerada um problema complexo devido à sua natureza combinatória e ao grande volume de reads

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42

Baashen, Mohammed Abdulwahhab M. "Synthesis, analysis and biological evaluation of heterocyclic drugs." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/45267/.

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Chapter 1: Chapter One provides an overview on the Bohlmann-Rahtz pyridine synthesis. New procedures, implementing metal based Lewis acids, Brønsted acids and metal-free Lewis acid catalysts have been used in this process. Also, new one-pot two- and three-component methodologies have been developed for the synthesis of various natural products containing the pyridine motif and these have been compared and contrasted. This chapter also discusses signalling pathways in Werner syndrome cells. The inhibitor SB203580 has been shown to prevent the phosphorylation of the p38α kinase in a ATP competit

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Griffiths, Natalie Jane. "Design, synthesis and biological evaluation of narciclasine analogues." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687347.

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Whilst the cultivation of the Amaryllidaceae genus has primarily been for their ornamental properties, their use in traditional medicine is also well documented. Although over 100 alkaloids from this genus have been isolated, the phenanthridinone analogues narciclasine and pancratistatin isolated from the daffodil bulb, are particularly interesting due to their cytostatic and cytotoxic properties. They have potent and selective anticancer activity which is seemingly unique when compared to currently available chemotherapeutic agents. However, they have yet to be fully exploited as therapeutic

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44

Aguiar, Gisele Rocha. "Chemical and biological evaluation of propolis of Alagoas." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15888.

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The red propolis originally from the state of Alagoas has a chemical composition rich in isoflavones and has been used as traditional popular medicine presented as an antioxidant and antiviral properties. Its relevance to this study is mainly due to the same present several biological properties, among them: antimicrobial, anti-cancer, cytotoxic and anti-tumor. In this work it was performed the study of the fixed compounds present in hexane fraction of propolis, which presented three esters: the methyl hexadecanoate (15,20%), the methyl tetracosanoate (10,40%) and the methyl octadecanoate (2,3

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45

Zheng, Changping. "Synthesis and biological evaluation of ganglioside GM3 analogues." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS432.

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Dans la présente étude, une série d’analogues du ganglioside GM3 avec des sialosides α-2, 6 contenant des sucres différents, y compris le galactose, le mannose, le lactose et la glucosamine, ont été entièrement synthétisés sur la base d’un protocole concis provenant de substrats et de réactifs disponibles dans le commerce. Et les blocs de construction de sucre avec un 6-OH libre ont été préparés par hydrolyse enzymatique, qui peut éviter de multiples procédures chimiques. En particulier, nous avons développé une nouvelle méthode chimioenzymatique pour synthétiser les dérivés glucosamine sialyl

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Fedorka, Sara R. "Synthesis and Biological Evaluation of Open-Chain Epothilones." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1342626312.

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Alqahtani, Abdulateef Alqarni. "Synthesis and Biological Evaluation of New HDAC Inhibitors." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525448898248748.

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Martins, Carla Sofia Barros. "Chemical characterization and biological evaluation of Salicornia ramosissima." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22783.

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Mestrado em Biotecnologia - Biotecnologia Alimentar<br>Atualmente, existe um elevado interesse na valorização de recursos naturais como fontes de compostos bioativos com potenciais efeitos benéficos para a saúde. A salicórnia é uma planta halófita que tem sido usada na alimentação e na medicina tradicional e mais recentemente no desenvolvimento de novos produtos alimentares, ilustrando o interesse da sua caracterização e avaliação. Esta planta encontra-se dispersa mundialmente, estando presente em algumas regiões em Portugal, nomeadamente na Ria de Aveiro e na Ria da Formosa, no Algarve. Esta

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Silva, Carlos Fábio Magalhães da. "Synthesis and biological evaluation of new 2-benzylchromones." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/21243.

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Mestrado em Bioquímica<br>Esta dissertação aborda a síntese de compostos do tipo cromona (4H-cromen-4-ona), em particular 2-benzilcromonas, com distintos padrões de substituição e também a avaliação da sua actividade anti-inflamatória e inibidora da acetilcolinesterase. As cromonas apresentam-se como sendo uma vasta classe de compostos naturais heterocíclicos contendo oxigénio e que representam o fragmento principal de diversos grupos de flavonoides amplamente distribuídos pela Natureza. Este tipo de compostos apresenta uma ampla gama de actividades biológicas e este esqueleto de cromona tem

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Arno, Maria Chiara. "Design, synthesis and biological evaluation of hepcidin analogues." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/design-synthesis-and-biological-evaluation-of-hepcidin-analogues(58e746c7-dbd9-4cbe-904c-0e5abe5b24b7).html.

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Hepcidin is a peptide hormone involved in the control of iron homeostasis. It has 25 amino acids with an antiparallel beta-sheet structure stabilized by four disulfide bonds. Hepcidin binds to the sole known iron exporter, ferroportin, leading to its internalization and degradation by a mechanism not fully understood. Hepcidin has an important role in iron metabolism disorders, such as hemochromatosis and anaemia. However, hepcidin analogues are currently not available for clinical use. The aims of this project are twofold: - to design and synthesise a fluorescent hepcidin analogue that can be

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