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Journal articles on the topic 'In vitro biological evaluation'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

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1

Morais, Shabna Roupal, R. Ram Narayanan, K. P. Sushmitha, N. Suchithra, Shruti Shankar, and M. Sugumar. "In vitro Biological Evaluation of Acanthophora spicifera." Research Journal of Pharmacy and Technology 13, no. 10 (2020): 4777. http://dx.doi.org/10.5958/0974-360x.2020.00840.9.

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Sheema, Sheema, Salman Zafar Salman Zafar, Nazif Ullah Nazif Ullah, Ishaq khan Ishaq khan, and and Ghias ud din and Ghias ud din. "Phytochemical and In Vitro Biological Evaluation of Roots of Malvastrum coromandelianum (L.) Garcke." Journal of the chemical society of pakistan 45, no. 6 (2023): 568. http://dx.doi.org/10.52568/001399/jcsp/45.06.2023.

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Malvastrum coromandelianum (L.) Garcke is a medicinal plant, employed traditionally for the treatment of different human illnesses. This study has been planned to study the chemical and biological aspects of the roots of the plant, using chemical and instrumental analytical techniques. Standard reported protocols were used for phytochemical screening of the crude extract, indicating the presence of terpenoids, steroids, flavonoids, and alkaloids classes of compounds. The extract was analyzed through Gas Chromatography-Mass Spectrometry (GC-MS) to confirm the presence of specific phytochemicals

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3

Yusuf, Abdullah, Jiang-Yu Zhao, Paruke Aibibula, Ju-Bao Zhang, Guo-Zheng Huang, and Haji Akber Aisa. "Synthesis and in vitro Biological Evaluation of Cananodine." HETEROCYCLES 102, no. 3 (2021): 506. http://dx.doi.org/10.3987/com-20-14394.

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4

Halik, Paweł K., Przemysław Koźmiński, Joanna Matalińska, Piotr F. J. Lipiński, Aleksandra Misicka, and Ewa Gniazdowska. "In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates." Pharmaceutics 14, no. 3 (2022): 607. http://dx.doi.org/10.3390/pharmaceutics14030607.

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Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed. Following this trend, we continued our evaluation of aprepitant-based 177Lu-radioconjugates in terms of future oncological applications. For this purpose, three novel aprepitant homologues were synthesized to broaden the previously obtained derivative portfolio, functionalized with the DOTA chelator and labeled with 68Ga and 177Lu. The newly evaluated radioconjugates showed the intended significant increase in lip

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Yi, Jiling, Zheng Zhao, Shipu Li, Yixia Yin, and Xinyu Wang. "In vitro biological evaluation of graphene on neuronal cells." Journal of Wuhan University of Technology-Mater. Sci. Ed. 31, no. 4 (2016): 925–30. http://dx.doi.org/10.1007/s11595-016-1469-6.

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Rafaat, Mahmood Sherzad, Arzu Karatepe, Serhat Keser, Şule İnci, and Semih Dalkılıc. "In vitro Biological Evaluation of 1,2,4-triazole Mannich Base." BioMed Target Journal 1, no. 2 (2023): 22–30. http://dx.doi.org/10.59786/bmtj.123.

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Biological evaluation of a 1,2,4-triazole mannich base that has been synthesized for interesting behavior in medicinal chemistry, so it’s interesting to synthesize triazole derivatives and investigate their biological properties to evaluate their capacity in medicine. The aim of this study evaluate the antimicrobial, anticancer, and antioxidant activities of a 1,2,4-triazole Mannich base derivative and its power in the treatment of diseases. For antimicrobial activity four bacterial strains and one fungal strain based on the agar disc diffusion. While used two cancer cell lines for anticancer

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7

Ourhzif, El-Mahdi, Caroline Decombat, Isabelle Abrunhosa-Thomas, et al. "Synthesis and Biological Evaluation of New Naphthoquinones Derivatives." Current Organic Synthesis 17, no. 3 (2020): 224–29. http://dx.doi.org/10.2174/1570179417666200212111956.

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: New substituted 1,4-naphthoquinones have been prepared in good overall yields through the naphthol route. The cytotoxicity of these compounds was tested in vitro on MCF-7 breast tumor cells. The most active compound 14 displayed an IC50 of 15μM. Objective: To investigate the cytotoxicity of new naphthoquinones derivatives on MCF-7 cells. Methods: Synthesis of new naphtoquinones derivatives and in vitro evaluation of their cytotoxicity on MCF-7 cells (rezasurin cell-based assay). Results: Starting from Ethyl 4-hydroxy-6,7-dimethoxy-2-naphthoate, four naphthoquinones were prepared and exhibite

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Venkateshwarlu, R., B. Chinnababu, U. Ramulu, et al. "Synthesis and biological evaluation of (−)-kunstleramide and its derivatives." MedChemComm 8, no. 2 (2017): 394–404. http://dx.doi.org/10.1039/c6md00606j.

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9

Vaesken, Antoine, Christian Pidancier, Nabil Chakfe, and Frederic Heim. "Hybrid textile heart valve prosthesis: preliminary in vitro evaluation." Biomedical Engineering / Biomedizinische Technik 63, no. 3 (2018): 333–39. http://dx.doi.org/10.1515/bmt-2016-0083.

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Abstract Transcatheter aortic valve implantation (TAVI) is nowadays a popular alternative technique to surgical valve replacement for critical patients. Biological valve tissue has been used in these devices for over a decade now with over 100,000 implantations. However, material degradations due to crimping for catheter insertion purpose have been reported, and with only 6-year follow-up, no information is available about the long-term durability of biological tissue. Moreover, expensive biological tissue harvesting and chemical treatment procedures tend to promote the development of syntheti

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10

Abdul-Rida, Nabeel A., and Kawther M. Talib. "NEW CHALCONE DERIVATIVES AS ANTICANCER AND ANTIOXIDANT AGENTS: SYNTHESIS, MOLECULAR DOCKING STUDY AND BIOLOGICAL EVALUATION." Chemical Problems 22, no. 2 (2024): 177–86. http://dx.doi.org/10.32737/2221-8688-2024-2-177-186.

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In this approach, a series of new chalcone derivatives bearing baclofen drug were synthesized via Claisen-Schmidt condensation and evaluated in vitro as anticancer and antioxidant agents. The newly synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra, and elemental analysis. All products were screened in vitro against both cell lines HdFn and MCF-7. The cytotoxicity assay results revealed that derivatives 5a and 5d exhibited good inhibition for cell lines MCF-7 with IC50 values 32.5 and 37.6 µM, respectively while 5a and 5c exhibited acceptable inhibition for HdFn with IC

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11

Niesyto, Katarzyna, Wiktoria Łyżniak, Magdalena Skonieczna, and Dorota Neugebauer. "Biological In Vitro Evaluation of PIL Graft Conjugates: Cytotoxicity Characteristics." International Journal of Molecular Sciences 22, no. 14 (2021): 7741. http://dx.doi.org/10.3390/ijms22147741.

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In vitro cytotoxicity of polymer-carriers, which in the side chains contain the cholinum ionic liquid units with chloride (Cl) or pharmaceutical anions dedicated for antituberculosis therapy, i.e., p-aminosalicylate (PAS) and clavulanate (CLV), was investigated. The carriers and drug conjugates were examined, in the concentration range of 3.125–100 μg/mL, against human bronchial epithelial cells (BEAS-2B) and adenocarcinomic human alveolar basal epithelial cells (A549) as an experimental model cancer cell line possibly coexisting in tuberculosis. The cytotoxicity was evaluated by MTT test and

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12

Hashimoto, Akiko, Takeji Takamura‐Enya, and Yoshimitsu Oda. "Synthesis and In Vitro Biological Evaluation of Psoralen‐Linked Fullerenes." Photochemistry and Photobiology 95, no. 6 (2019): 1403–11. http://dx.doi.org/10.1111/php.13138.

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13

Alam, Fiaz, and Qazi Najam us Saqib. "Evaluation of Zanthoxylum armatum Roxb for in vitro biological activities." Journal of Traditional and Complementary Medicine 7, no. 4 (2017): 515–18. http://dx.doi.org/10.1016/j.jtcme.2017.01.006.

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14

Zhang, Yaling, Ying Zhang, Juan Liu, et al. "Synthesis and in vitro biological evaluation of novel quinazoline derivatives." Bioorganic & Medicinal Chemistry Letters 27, no. 7 (2017): 1584–87. http://dx.doi.org/10.1016/j.bmcl.2017.02.027.

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15

Soni, Love Kumar, Tamanna Narsinghani, and Anand Sethi. "Anti-microbial benzimidazole derivatives: synthesis and in vitro biological evaluation." Medicinal Chemistry Research 21, no. 12 (2012): 4330–34. http://dx.doi.org/10.1007/s00044-012-9976-2.

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16

Kainthan, Rajesh Kumar, Samuel R. Hester, Elena Levin, Dana V. Devine, and Donald Elliott Brooks. "In vitro biological evaluation of high molecular weight hyperbranched polyglycerols." Biomaterials 28, no. 31 (2007): 4581–90. http://dx.doi.org/10.1016/j.biomaterials.2007.07.011.

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17

Ventura, Cinzia Anna, Carmela Cannavà, Rosanna Stancanelli, et al. "Gemcitabine-loaded chitosan microspheres. Characterization and biological in vitro evaluation." Biomedical Microdevices 13, no. 5 (2011): 799–807. http://dx.doi.org/10.1007/s10544-011-9550-6.

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18

Baranyai, Zsuzsa, Martin Krátký, Rudolf Vosátka, et al. "In vitro biological evaluation of new antimycobacterial salicylanilide-tuftsin conjugates." European Journal of Medicinal Chemistry 133 (June 2017): 152–73. http://dx.doi.org/10.1016/j.ejmech.2017.03.047.

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19

Smit, Frans J., Riëtte A. van Biljon, Lyn-Marie Birkholtz, and David D. N'Da. "Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters." European Journal of Medicinal Chemistry 90 (January 2015): 33–44. http://dx.doi.org/10.1016/j.ejmech.2014.11.016.

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20

Mankhi, Rusul Naeim, and Nabeel A. Abdul-Rida. "NEW FENOFIBRATE DERIVATIVES AS ANTICANCER AND ANTIOXIDANT AGENTS: SYNTHESIS, IN SILICO STUDY AND BIOLOGICAL EVALUATION." Chemical Problems 23, no. 2 (2025): 286–93. https://doi.org/10.32737/2221-8688-2025-2-286-293.

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Fenofibrate is a medication derived from fibric acid that is used to treat severe cases of high triglyceride levels and a combination of abnormal lipid levels in individuals who have not shown improvement with nonpharmacological treatments. As part of this research, novel classes of Fenofibrate derivatives were synthesized and evaluated in vitro as anticancer and antioxidant agents. Spectroscopic techniques, including infrared, NMR and elemental analysis, were used to validate their structures conclusively. all products were screened in vitro against cell lines MDA-MB-231. The cytotoxicity ass

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21

Mishra, Shweta, Debashree Das, Adarsh Sahu, Shailendra Patil, Ram Kishore Agrawal, and Asmita Gajbhiye. "Phosphonate Derivatives of 3,5-bis(arylidene)-4-piperidone: Synthesis and Biological Evaluation." Anti-Infective Agents 18, no. 3 (2020): 245–54. http://dx.doi.org/10.2174/2211352517666190820143735.

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Background: 3,5-Bis(arylidene)-4-piperidinones (BAP) belong to a wide class of cross conjugated dienones. The 1,5-diaryl-3-oxo-1,4-pentadienyl fragment of the BAP moiety is responsible for the molecule's anti-tumor, antioxidant, antimicrobial and anti-inflammatory manifestations. In the present study, we present combinations of phosphonate and 3,5-bis(arylidene)-4- piperidone pharmacophores. The anti-inflammatory, anti-oxidant potential, anti-proliferative, cytotoxic potential and antimicrobial of the title compounds were evaluated in in-vitro bioassay paradigms. Methods: A novel class of phos

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22

Aditi, Rajendra Late* Kadam Vaibhav N. Dr. Rahane Rahulkumar D. "Synthesis and in vitro Evaluation of Novel Thiophene Derivatives." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3541–46. https://doi.org/10.5281/zenodo.15478486.

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sulfur-containing heterocycles used to create a wide variety of sophisticated compounds with a wide range of biological functions, they are valuable analogs for medicinal chemists. Synthesis novel thiophene derivative by Schiff base were validated by FTIR, MS and 1H-NMR. The produced compounds were additionally assessed for their in vitro biological potentials, specifically antimicrobial activity against chosen microbial species utilizing tube dilution method. Antimicrobial screening outcomes revealed that compound S1 emerged as the most effective antibacterial agent against Staphylococcus aur

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23

Lohe, Radhika G., Vijay Mahajan, and Deepali M. Jagdale. "SYNTHESIS, MOLECULAR DOCKING AND BIOLOGICAL EVALUATION OF STEROIDAL CYTOTOXIC AGENTS." INDIAN DRUGS 62, no. 01 (2025): 18–27. https://doi.org/10.53879/id.62.01.14996.

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Steroidal chalcones, hybrid molecules possessing characteristics of both, a steroid and a chalcone, have drawn the interest of researchers exhibiting potential biological activities and pharmacological properties. In continuation, of our previous research wherein steroidal derivatives were synthesized and evaluated, 20 steroidal chalcones were designed and screened for inhibition of HhSP targeting the Smoothened receptor (PDB ID: 4JKV) by preliminary molecular docking analysis using AutoDock tools with Cygwin 64 terminal software. Out of these, 9 steroidal chalcones showing the best dock score

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24

Kumar Baba, N. H., D. Ashok, Boddu Ananda Rao, Sarasija Madderla, and N. Y. S. Murthy. "Microwave-assisted synthesis and biological evaluation of thiazole-substituted dibenzofurans." Heterocyclic Communications 24, no. 3 (2018): 171–76. http://dx.doi.org/10.1515/hc-2017-0247.

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AbstractNew thiazole-substituted dibenzofurans 7a–j were synthesized from dibenzofuran derivatives 5a–b and substituted thiosemicarbazones 6a–h under conventional and microwave irradiation conditions. The structures of all products were established on the basis of analytical and spectral data. The synthesized compounds were evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative strains. Compounds 7b, 7d and 7h are active against Bacillus subtilis (+ve), and compound 7i displays good activity against Pseudomonas aeruginosa (-ve) strain. Compounds 7a–j were a

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25

Liu, Gai-Zhi, Yan-Bin Guan, Ya Wu та Hong-Min Liu. "Synthesis and Biological Evaluation of Novelγ-Alkylidene Butenolides". Journal of Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/926723.

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Three new series of 4-substituted-5-alkylidene-2,5-dihydrofuran-2-ones were synthesized. The in vitro activity test results showed that some of them exhibited good antibacterial and cytotoxic activities. Among them compound5cshowed the most potent antibacterial activity againstEscherichia coliwith the MIC value of 20.00 μg/mL. Compound9cshowed good cytotoxic activity against Ec9706 cells withIC50value of 19.39 μM, better than that of the reference compound fluorouracil (IC50=37.74 μM).

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26

M. Hassan, M. Hassan, Zafar Iqbal Zafar Iqbal, Fazli Nasir Fazli Nasir, et al. "Simultaneous Determination of Etoposide and Paclitaxel in Biological and Pharmaceutical Samples by RP-HPLC; Method Development." Journal of the chemical society of pakistan 41, no. 5 (2019): 874. http://dx.doi.org/10.52568/000790/jcsp/41.05.2019.

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A simple, rapid and sensitive RP-HPLC-UV method was developed for quantification of paclitaxel (PTX) and etoposide (ETO) in biological and pharmaceutical samples. Optimization of experimental conditions were performed and standard guidelines were used for the validation of the method. Analytes were separated on Pruospher® Star RP- 18e (250mm × 4.6mm, 5µm) column using ACN and TFA (0.025%) as mobile phase in the ratio of (60:40V/V) with a flow rate of 1 mL/min and detector set at 235 nm. Protein precipitation method was applied for the extraction of analytes from biological samples. The method

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27

Ju liu, Ju liu, Jun Li Jun Li, Jian tao Shi Jian tao Shi, et al. "Synthesis and Biological Evaluation of Novel 4-Phenylaminobenzofuro[2,3-d]pyrimidine Derivatives." Journal of the chemical society of pakistan 42, no. 4 (2020): 564. http://dx.doi.org/10.52568/000659.

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A series of novel 4-phenylaminobenzofuro[2,3-d]pyrimidine derivatives had been prepared and assessed for their in vitro antiproliferative activities against three lung cancer cell lines (A549, H460 and H1975). The bioassay results showed most of the designed compounds exhibited potential antiproliferation activities. Among them, compound 8f exhibited remarkable inhibitory activity against A549 and H460 cell lines with IC50 value of 2.54 μM and 2.68 μM, respectively, which was comparable to that of the positive control sorafenib (IC50 = 2.69 μM for A549 and 3.71 μM for H460). AO/EB staining sug

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Ju liu, Ju liu, Jun Li Jun Li, Jian tao Shi Jian tao Shi, et al. "Synthesis and Biological Evaluation of Novel 4-Phenylaminobenzofuro[2,3-d]pyrimidine Derivatives." Journal of the chemical society of pakistan 42, no. 4 (2020): 564. http://dx.doi.org/10.52568/000659/jcsp/42.04.2020.

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A series of novel 4-phenylaminobenzofuro[2,3-d]pyrimidine derivatives had been prepared and assessed for their in vitro antiproliferative activities against three lung cancer cell lines (A549, H460 and H1975). The bioassay results showed most of the designed compounds exhibited potential antiproliferation activities. Among them, compound 8f exhibited remarkable inhibitory activity against A549 and H460 cell lines with IC50 value of 2.54 μM and 2.68 μM, respectively, which was comparable to that of the positive control sorafenib (IC50 = 2.69 μM for A549 and 3.71 μM for H460). AO/EB staining sug

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29

TURCOV, DELIA, ANIȘOARA CĂTĂLINA PEPTU, ANCA ZBRANCA, and DANIELA ȘUTEU. "In Vitro Evaluation of the Dermatocosmetic Emulsions Based on Saffron (Crocus sativus) Alchoolic Extracts." Buletinul Institutului Politehnic din Iași, Secția Chimie și Inginerie Chimică 69, no. 2 (2023): 39–46. https://doi.org/10.5281/zenodo.8162661.

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The dermatocosmetic emulsion at the centre of this work simultaneously responds to the multiple needs of patients, related to the protective effects provided by the ingredients, but also to the comfort and pleasure in using the product. At the same time, the biologically active ingredients have a unique source, by capitalizing on the floral residues of saffron rich in biological compounds with significant antioxidant activity. The aim of this article is to test in vitro the behavior of some emulsions based on Saffron (<em>Crocus sativus</em>) plant extract. The results of the in vitro tests co

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30

Ribeiro, Carlos J. A., Joana D. Amaral, Cecília M. P. Rodrigues, Rui Moreira, and Maria M. M. Santos. "Spirooxadiazoline oxindoles with promising in vitro antitumor activities." MedChemComm 7, no. 3 (2016): 420–25. http://dx.doi.org/10.1039/c5md00450k.

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31

Marionnet, Claire, and Françoise Bernerd. "In Vitro Skin Models for the Evaluation of Sunscreen-Based Skin Photoprotection: Molecular Methodologies and Opportunities." Current Medicinal Chemistry 26, no. 10 (2019): 1874–90. http://dx.doi.org/10.2174/0929867324666170303124247.

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Identifying and understanding the biological events that occur following ultraviolet (UV) exposure are mandatory to elucidate the biological and clinical consequences of sun exposure, and to provide efficient and adequate photoprotection strategies. The main UVinduced biological features (markers related to sunburn, cancer, photoaging immunosuppression, pigmentation), characterized in human skin in vivo, could be reproduced in adapted models of reconstructed skin in vitro, attesting their high relevance in the field of photobiology. In turn, 3D skin models were useful to discover precise biolo

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32

Godwin, Lisa A., Divya Sukumar, Sarah Moreno, et al. "Biological Evaluation of a Native Amniotic Membrane Allograft." Foot & Ankle Orthopaedics 7, no. 4 (2022): 2473011421S0067. http://dx.doi.org/10.1177/2473011421s00672.

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Category: Basic Sciences/Biologics; Other Introduction/Purpose: Placental tissue allografts have long been used as effective wound dressings for hard to heal wounds and are demonstrating increasing utility in the field of foot and ankle surgeries. Previous observations of the PURION-processed dehydrated amnion/chorion membrane (dHACM) demonstrated retention of regulatory proteins inherent to amniotic tissues and preservation of the bioactivity to stimulate cellular activities. Novel and patent-pending processing techniques have been developed to introduce a thicker and more robust allograft, a

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33

Woźnica, Iwona, Wioletta Szeszel-Fedorowicz, Grzegorz Rosińskiand, and Danuta Konopińska. "Biological evaluation of analogues of an insect neuropeptide proctolin." Acta Biochimica Polonica 51, no. 1 (2004): 115–19. http://dx.doi.org/10.18388/abp.2004_3602.

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Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.

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Reddy, Janardan K., M. Sambasiva Rao, and Anjana V. Yeldandi. "Peroxisome Proliferation: A Biological Marker for Toxicological Evaluation." Journal of the American College of Toxicology 11, no. 3 (1992): 349–52. http://dx.doi.org/10.3109/10915819209141874.

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Peroxisome proliferators constitute an important group of xenobiotics with therapeutic, societal, and agricultural importance. Because these agents induce liver tumors in rodents, but fail to exert the genotoxic or mutagenic effects directly in short-term in vitro test systems, they are considered a paradigm to investigate the mechanisms of nongenotoxic hepatocarcinogenesis. A concerted cell biological, biochemical, and molecular biological approach is essential to understand the relationship of xenobiotic-induced peroxisome proliferation to the eventual development of liver tumors. It is our

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Marcinčáková, D., N. Červeňáková, and M. Miłek. "In vitro Evaluation of Biological Effects of Dandelion (Taraxacum officinale) Extracts." Folia Veterinaria 62, no. 3 (2018): 36–40. http://dx.doi.org/10.2478/fv-2018-0025.

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Abstract Dandelion (Taraxacum officinale) of the Asteraceae family is known for its pharmacological effects and has been used in therapy for centuries. Currently extracts of all parts of this plant are used — root, leaves and flowers. The extracts are prepared using various extraction agents that may significantly affect the effectiveness and therapeutic spectrum of the extracts. The aim of this study was to use three different solvents for the preparation of the extracts from dandelion (Taraxacum officinale) leaves and flowers, namely triton X-100 (2 %), nonidet P-40 (2 %) and acetone (30 %).

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Ceyhan Güvensen, Nur, Mehlika Alper, and Aylin Taşkaya. "Evaluation of Biological Activities of Exopolysaccharide from Rhodococcus pyridinivorans In vitro." European Journal of Research and Development 2, no. 2 (2022): 491–504. http://dx.doi.org/10.56038/ejrnd.v2i2.46.

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Microbial exopolysaccharides (EPSs) are biopolymers in the form of carbohydrates produced by many microorganisms and secreted into the external environment. EPS protects the microorganism from drying, phagocytosis, and phage effects, and acts as a barrier in stress environments such as heat, light and sound. EPSs produced for industrial purposes are generally used in areas such as food, cosmetics, petroleum and chemistry. This study was aimed to investigate in addition to basic physical and chemical properties of R. pyridinovorans EPS, in vitro its biological activities such as antioxidant pro

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Pacholak, P., J. Krajewska, P. Wińska, et al. "Development of structurally extended benzosiloxaboroles – synthesis and in vitro biological evaluation." RSC Advances 11, no. 41 (2021): 25104–21. http://dx.doi.org/10.1039/d1ra04127d.

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이인철, Kim Dae Yong, 문지영, 박병권, and 김정미. "In Vitro Evaluation of Biological Activities of Jeju Island Plants Mixture." Journal of Investigative Cosmetology 14, no. 1 (2018): 39–45. http://dx.doi.org/10.15810/jic.2018.14.1.005.

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39

Fonseca, Fernando L. A., Taiana C. Caetano, Carolina Z. P. Mecca, et al. "In vitro Evaluation of Biological Effects of Metallic Compounds with Quinolines." Current Enzyme Inhibition 14, no. 1 (2018): 18–25. http://dx.doi.org/10.2174/1573408013666170213152751.

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40

Erhabor, J. O., A. G. Omokhua, and L. J. McGaw. "In vitro biological activities and safety evaluation of Raphia hookeri (Arecaceae)." South African Journal of Botany 115 (March 2018): 284–85. http://dx.doi.org/10.1016/j.sajb.2018.02.036.

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41

Bettio, F., M. Canevari, C. Marzano, et al. "Synthesis and Biological In Vitro Evaluation of Novel PEG−Psoralen Conjugates." Biomacromolecules 7, no. 12 (2006): 3534–41. http://dx.doi.org/10.1021/bm060760n.

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42

Hassan, Sadaf ul, Murtaza Hasan, Attia Firdous, and Muhammad Asim Farid. "Preparation, Characterization and In Vitro Biological Evaluation of Nano-Tubular Polyoxometalate." Journal of Nanoscience and Nanotechnology 17, no. 7 (2017): 4882–87. http://dx.doi.org/10.1166/jnn.2017.13459.

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Bodiga, Vijaya Lakshmi, Sasidhar Reddy Eda, Saishashank Chavali, et al. "In vitro biological evaluation of glyburide as potential inhibitor of collagenases." International Journal of Biological Macromolecules 70 (September 2014): 187–92. http://dx.doi.org/10.1016/j.ijbiomac.2014.06.054.

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Napimoga, Marcelo Henrique, Ana Paula Dias Demasi, Christian Rado Jarry, Mauricio Cardoso Ortega, Vera Cavalcanti de Araújo, and Elizabeth Ferreira Martinez. "In vitro evaluation of the biological effect of SOFAT on osteoblasts." International Immunopharmacology 26, no. 2 (2015): 378–83. http://dx.doi.org/10.1016/j.intimp.2015.04.033.

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Xu, Yuanting, Li Li, Hao Wang, et al. "In vitro cytocompatibility evaluation of alginate dialdehyde for biological tissue fixation." Carbohydrate Polymers 92, no. 1 (2013): 448–54. http://dx.doi.org/10.1016/j.carbpol.2012.09.096.

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Perdomo, F., R. Ech�vez-Badel, M. Alameda, and E. C. Schr�der. "In vitro evaluation of bacteria for the biological control ofMacrophomina phaseolina." World Journal of Microbiology & Biotechnology 11, no. 2 (1995): 183–85. http://dx.doi.org/10.1007/bf00704645.

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Tran, UyenPhuong, and Kelvin L. Billingsley. "Biological evaluation of indolactams for in vitro bryostatin 1-like activity." Bioorganic & Medicinal Chemistry Letters 97 (December 2023): 129570. http://dx.doi.org/10.1016/j.bmcl.2023.129570.

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Dmytrenko, Oleksandra, Maryna Arkhypova, Darya Starosyla, Svitlana Rybalko, Michael Gevorkyan, and Alexander Galkin. "Biological Evaluation of Medical Devices in the Form of Suppositories for Rectal and Vaginal Use." Innovative Biosystems and Bioengineering 5, no. 4 (2021): 228–37. http://dx.doi.org/10.20535/ibb.2021.5.4.249082.

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Abstract:

Background. Programs of preclinical safety studies of the health care products depend on the regulatory status of the investigated products. The classification of such products, in particular suppositories for rectal and vaginal use, is a critical step of developing tactics for their biological evaluation. Adaptation of biological evaluation methods for the medical devices based on the combination of biologically active substances, as well as evaluation of the results of such studies is urgent task of biomedicine. Objective. To substantiate the regulatory status and to carry out a biological e

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Lad, Chaitali, Ishan Panchal, Ashish Patel, et al. "In silico analysis, synthesis and biological evaluation of DHFR inhibitors." Folia Medica 63, no. 5 (2021): 745–59. http://dx.doi.org/10.3897/folmed.63.e56786.

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Introduction: Malaria is one of the varieties of fatal diseases caused by a protozoan parasite that is now considered to be the greatest global health challenge. A parasite of Plasmodium species triggers it transmitting the disease to humans by the bites of female Anopheles mosquitoes. Aim: To screen out designed molecules by molecular docking analysis and assess their pharmacokinetic properties using SwissADME. To synthesize the designed compounds. To characterize the synthesized compounds by TLC, melting point, IR spectroscopy, mass spectrometry, 1H NMR, and 13C NMR. To evaluate the synthesi

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Świątek, Piotr, Katarzyna Gębczak, Tomasz Gębarowski, and Rafal Urniaz. "Biological Evaluation and Molecular Docking Studies of Dimethylpyridine Derivatives." Molecules 24, no. 6 (2019): 1093. http://dx.doi.org/10.3390/molecules24061093.

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Cyclooxygenase inhibitors as anti-inflammatory agents can be used in chemoprevention. Many in vitro and in vivo studies on human and animal models have explained the mechanisms of the chemopreventive effect of COX inhibitors such as: induction of apoptosis, inhibition of neoplasia, angiogenesis suppression, induction of cell cycle inhibition and inhibition of the expression of peroxisome proliferator-activated receptors. Here, biological evaluation of twelve different Schiff base derivatives of N-(2-hydrazine-2-oxoethyl)-4,6-dimethyl-2-sulfanylpyridine- 3-carboxamide are presented. Their in vi

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