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Dissertations / Theses on the topic 'In vitro cultured'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Cookson, Mark R. "Studies of activation and toxicity in cultured astrocytes." Thesis, University of Salford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308094.

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2

Lawrence, J. N. "Cryopreservation and toxicity studies with cultured rat and human hepatocytes." Thesis, University of Surrey, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233123.

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3

Gough, Julie. "Apoptosis of human osteoblasts cultured on polymeric biomaterials in vitro." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298960.

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4

Gibson, Bethany Gale. "Improving the development of bovine in vitro produced embryos cultured individually." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/49694.

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Previous research in bovine embryology has found that embryos cultured individually have limited ability to develop compared to their counterparts cultured in a group of other embryos. This investigation aimed to find if any of three different interventions over two experiments would increase development of individually cultured embryos to that of group cultured embryos. In the first experiment both the addition of serum/serum replacer and a co-culture with bovine granulosa cells were applied to individually cultured embryos in a 3x2 design. None of the interventions was found to be signifi

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5

Pijut, Paula M. "Effects of culture filtrates of Ceratocystis ulmi on growth and ultrastructure of in vitro cultured Ulmus Americana /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu148759742413622.

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6

Kawarsky, Sheldon Jerald. "Effects of elevated temperature on bovine oocytes and embryos cultured in vitro." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0001/NQ40376.pdf.

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7

Bedi, Seema. "Environmental stress and the response of pinus caribaea Morelet cultured in vitro." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335043.

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8

Turgut, Emine. "Characterisation and detection of Renibacterium salmoninarum cultured in vivo and in vitro." Thesis, University of Stirling, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250258.

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9

Van, Tonder Jacob John. "Development of an in vitro mechanistic toxicity screening model using cultured hepatocytes." Thesis, University of Pretoria, 2011. http://hdl.handle.net/2263/24162.

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In vitro testing includes both cell-based and cell-free systems that can be used to detect toxicity induced by xenobiotics. In vitro methods are especially useful in rapidly gathering intelligence regarding the toxicity of compounds for which none is available such as new chemical entities developed in the pharmaceutical industry. In addition to this, in vitro investigations are invaluable in providing information concerning mechanisms of toxicity of xenobiotics. This type of toxicity testing has gained popularity among the research and development community because of a number of advantages s

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10

Koeman, Jennifer. "Developmental competence of prepubertal and adult goat oocytes cultured in semi-defined media." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33417.

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In vitro production of embryos from oocytes recovered by laparoscopic oocyte pick-up (LOPU) offers great potential for the propagation of genetically valuable animals. In turn, the application of these techniques to prepubertal animals presents added benefits in that prepubertal animals may supply a greater number of oocytes than adult animals. The aim of the present study was to evaluate the developmental competence of prepubertal and adult goat oocytes cultured in semi-defined media. The follicular response and recovery of oocytes via LOPU from hormonally stimulated prepubertal and adult goa

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11

Munif, Farina. "Expression of Mitochondrial Stress Protein (Cpn60) in in vitro Cultured Neonatal Porcine Islet Cells." The University of Waikato, 2006. http://hdl.handle.net/10289/2510.

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Xenotransplantation of neonatal porcine islets have been demonstrated to be a viable alternative to exogenous insulin therapy for diabetes mellitus. The use of liberase has gained much success in islet isolation but factors such as batch-to-batch variation and deterioration of a batch with storage time have hampered the quality and reproducibility of tissue dissociation. Islet culture aims to optimise islet survival and insulin release in response to glucose challenge. However, it is difficult to recover and preserve islets in vitro. Mitochondria play a key role in the secretion of insulin fr

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12

Sessions, John W. "In Vitro Molecular Modification of Human Cultured and Primary Cells Using Lance Array Nanoinjection." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5859.

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Fundamentally altering cellular function at a genetic level is a major area of interest in the biologic sciences and the medical community. By engineering transfectable constructs that can be inserted to dysfunctional cellular systems, scientists can mitigate aberrant genetic behavior to produce proper molecular function. While viral vectors have been a mainstay in the past, there are many limitations, particularly related to safety, that have changed the focus of genome editing to incorporate alternative methods for gene delivery. Lance Array Nanoinjection (LAN), a second-generation microfabr

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13

Do, Dang Giap, Thi Kim Thuy Dang, Thi Huyen Trang Nguyen, Thi Duoc Nguyen, Trong Tuan Tran, and Duc Hieu Duong. "Effects of nano silver on the growth of banana (Musa spp.) cultured in vitro." Technische Universität Dresden, 2018. https://tud.qucosa.de/id/qucosa%3A33343.

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Nano silver has positive effects on the growth and development of in vitro plants. In this study, shoots of in vitro banana with 1 cm in length were cut off the tip which was cultured in Murashige and Skoog (MS) medium supplemented with 30 g.L-1 sucrose, 15% coconut water (v/v), 5 mg. L-1 6-Benzyladenine (BA), 8 g.L-1 agar and nano silver (1, 3, 5, 7 ppm). After twenty days cultured, shoots in the medium supplemented with 1 ppm nano silver have grown well with 8.4 times multiplication and total chlorophyll content (2.05 mg.g-1), three-fold higher than in the control experiment. All new shoot s

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14

Nugroho, Laurentius Hartanto. "Hyperhydricity of in vitro cultured Sturt's desert pea (Swainsona formosa) and techniques for its minimisation." Title page, contents and summary only, 1995. http://web4.library.adelaide.edu.au/theses/09A/09an968.pdf.

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Bibliography: leaves 74-80. This study shows techniques for reducing hyperhydricity in the micropropagation of Sturt's desert pea. The effects of support matrix, tube closure and cytokinin regime are examined and the anatomy of hyperhydric shoots is investigated.

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15

Hehenberger, Karin M. "In vitro studies of the diabetic condition using cultured fibroblasts with focus on wound healing /." Stockholm, 1997. http://diss.kib.ki.se/1997/19971219hehe.

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16

Hogwood, Caterine Elizabeth. "Responses of in vitro cultured human cells to cisplatin with respect to p53 expression levels." Thesis, University of Kent, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523636.

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17

Aye, Felicia Yeboaa Okraku. "Cultural and environmental effects on lipid accumulation during embryogenesis of zygotic and somatic embryos of Theobroma cacao L. cultured in vitro." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269743.

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18

Leclerc, Yves. "Acclimatization, field performance and microtuberization of tissue cultured potato (Solanum tubererosum L.) cv. Russet Burbank." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61861.

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19

Corradini, Daniele. "Statistical characterization of cultured neural networks activity recorded via MEA." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20380/.

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In questa tesi si sono analizzate le attività di neuroni in coltura accoppiati con un Multi-Electrode Array (MEA) a 60 canali. Le reti neurali in vitro sono influenzate da diversi fattori, come la densità di coltura, l'età e l'animale di provenienza dei neuroni. Lo scopo di questa tesi è quello di caratterizzare questa variabilità attraverso varie analisi statistiche. Utilizzando un software sviluppato in Python si sono estratte 40 misure per descrivere un ampio spettro delle attività delle cellule, come lo spiking e i network bursts. Sono state caratterizzate le distribuzioni statistich

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20

Kemp, Graham John. "In vitro studies of intracellular orthophosphate metabolism in human red blood cells and cultured multicompartment cells." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259803.

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21

Hernández-Jáuregui, y. Alvarez Pablo. "The pathogenesis of the Porcine rubulavirus (LPMV) : infection in PK-15 cultured cells and in experimentally infected pigs /." Uppsala : Dept. of Veterinary Microbiology, Swedish Univ. of Agricultural Sciences, 2003. http://epsilon.slu.se/v155-ab.html.

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22

Silva, Rayanne Farias da. "Histological analysis of tissues cultured in vitro laticÃferas plants, soluble protein profile and action against plant pathogens." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14733.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Laticifers plants have been studied by presenting a wide range of proteins related to plant defense in its latex. The aim of this study was to investigate, in tissue cultured in vitro, proteins and activities described for latex laticÃferas two species. Tissue callus and roots of Cryptostegia grandiflora were obtained by in vitro tissues culture protocols and subjected to histological analysis for laticifers characterization. Cultured tissue of Calotropis procera were used as comparative reference in the analysis. There wasnât any l

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23

Gilchrist, Fiona M. "The activity of pH membrane disruptive pseudopeptides and their subcellular fate in mammalian cells cultured in-vitro." Thesis, Aston University, 2002. http://publications.aston.ac.uk/9665/.

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This thesis describes investigations upon pseudopeptides which were conducted to improve our understanding of the fate of synthetic macromolecules in cells and to develop approaches to influence that fate. The low uptake of molecules across the external cellular membrane is the principal barrier against effective delivery of therapeutic products to within the cell structure. In nature, disruption of this membrane by amphiphilic peptides plays a central role in the pathogenesis by bacterial and toxin infections. These amphiphilic peptides contain both hydrophobic and weakly charged hydrophilic

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24

Nawaz, Qamar. "Comparison and characterisation of ribozyme delivery in cultured glial and neuronal cells in vivo and in vitro." Thesis, Aston University, 2003. http://publications.aston.ac.uk/12367/.

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Ribozymes are short strands of RNA that possess a huge potential as biological tools for studying gene expression and as therapeutic agents to down-regulate undesirable gene expression. Successful application of ribozymes requires delivery to the target site in sufficient amounts for an adequate duration. However, due to their large size and polyanionic character ribozymes are not amenable to transport across biological membranes. In this study a chemically modified ribozyme with enhanced biological stability, targeted against the EGFR mRNA has been evaluated for cellular delivery to cultured

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25

Clail, Ilona. "The development of embryos from bovine oocytes cultured in vitro : relation to ovarian activity and steroidogenesis in follicular fluid, maturation media and culture media." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068349.

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The present study was undertaken to examine the effect of ovary type on <I>in vitro</I> production of embryos. Experiment 1 examined the effect of the presence or absence of a corpus luteum and/or large follicle(s) on an ovary, on the development of oocytes to embryos at the blastocyst stage. Experiment 2 investigated whether the ovary type used as the source of granulosa cells in culture (as supplementary cells and for monolayers), affected <I>in vitro</I> production of embryos at the blastocyst stage. The concentrations of progesterone, oestradiol-17B and testosterone in follicular fluid (ex

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26

Apostolakos, Persefoni. "Studies on receptor specific hormonotoxin on cultured Leydig tumor cells in vitro and in normal mice in vivo." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22845.

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Modern cancer therapy has explored the use of enzymatically acting toxins coupled to specific binding proteins in an attempt to destroy specific cell populations. In light of these new therapies we have synthesized two hormonotoxins (HTs): (i) composed of the ribosome inactivating plant protein gelonin conjugated to luteinizing hormone (LH), (ii) gelonin conjugated to human chlorionic gonadotropin (hCG), both through a disulfide bond.<br>Characterization of both conjugates was carried out by SDS-PAGE analysis, radioimmunoassay and Western blotting (using polyclonal antibodies against both the

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27

Marchant, Rosalyn J. "Towards a better understanding of the molecular responses of in vitro cultured mammalian cells to sub-physiological temperatures." Thesis, University of Kent, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497675.

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28

Smith, Matthew Edward. "The chaperonin containing t-complex polypeptide-1 (CCT) and recombinant protein production from in vitro cultured mammalian cells." Thesis, University of Kent, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527574.

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29

Lopez, Elena Maria. "In-vitro assessment of estrogenicity in wastewater treatment plant effluents using cultured liver and testis from fathead minnow." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3322538.

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30

Palanca-Wessels, Maria Corinna. "In vitro analysis of cultured Barrett's esophagus cells : insights into mechanisms of genomic instability and possible therapeutic strategies /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/4995.

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31

Nannmark, Ulf. "Tumour cell rheology experimental studies in vivo and in vitro on factors influencing tumor cell lodgement and survival in microvessels /." Göteborg : Dept. of Anatomy, University of Göteborg, 1992. http://books.google.com/books?id=9PhpAAAAMAAJ.

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32

Attfield, Elizabeth Margaret. "An analysis of the stages of organogenesis in leaf explants of Nicotiana tabacum L. CV. Xanthi NC. cultured in vitro." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303344.

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33

Taylor, Lucy Gray. "The influence of in vitro KCl treatments on the water relations and acclimatization of tissue-cultured Flame Azalea (Rhododendron calendulaceum)." Thesis, Virginia Tech, 1990. http://hdl.handle.net/10919/42231.

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Propagation by tissue culture is effective for many woody ornamental plants, but propagules often become desiccated and die during the acclimatization period. This loss is due in part to stomata that fail to close in response to the reduced humidity outside of the culture environment. KCl was used in in vitro treatments to determine if an additional K supply would improve microshoot stomatal function and water status during acclimatization. The effects of the KCl treatments upon subsequent microshoot rooting and percent fresh weight gain were also evaluated. In preliminary experiments, micro

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34

Hinoue, Atsushi. "Disruption of actin cytoskeleton and anchorage-dependent cell spreading induces apoptotic death of mouse neural crest cell cultured in vitro." Kyoto University, 2005. http://hdl.handle.net/2433/144698.

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35

Chiba, Yoichi. "Cultured murine dermal fibroblast-like cells from senescence-accelerated mice as in vitro models for higher oxidative stress due to mitochondrial alterations." Kyoto University, 2005. http://hdl.handle.net/2433/144488.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第11854号<br>医博第2907号<br>新制||医||908(附属図書館)<br>23634<br>UT51-2005-N688<br>京都大学大学院医学研究科脳統御医科学系専攻<br>(主査)教授鍋島陽一, 教授淀井淳司, 教授芹川忠夫<br>学位規則第4条第1項該当

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36

Chen, Patty P. 1981. "Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28758.

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Thesis (M. Eng.)--Harvard-MIT Division of Health Sciences and Technology, 2004.<br>Includes bibliographical references (p. 76-77).<br>The focus of this study was to investigate the histology of tissue formed when fetal (16-20 days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed a collagen-GAG scaffold specifically developed for tissue engineering and investigated the effect of this substratum on the formation of lung histotypic structures in vitro. A cell isolation procedure was developed whereby 19-days gestation t

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37

Lund, Loren Glen. "Mobilization of Iron Enhances the Iron-Dependent Biochemical Reactivity of Asbestos in Vitro and Contributes to the Cytotoxicity of Asbestos in Cultured Cells." DigitalCommons@USU, 1992. https://digitalcommons.usu.edu/etd/7174.

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Asbestos related research began approximately 60 years ago, yet, the mechanism(s) by which asbestos exerts its biological effects is not well understood. The hypothesis upon which this dissertation is based is that mobilization of iron from asbestos enhances the iron-dependent biochemical reactivity of asbestos in vitro and contributes to asbestos-dependent cytotoxicity. The specific aims for this hypothesis were, 1) to determine whether iron was responsible for the biochemical reactivity of asbestos in vitro and asbestos-induced cytotoxicity in cultured cells, and 2) to determine whether mobi

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38

Balghonaim, Abir A. "Effect of platelet factors and thrombin on multiplication of human bone marrow mesenchymal stem cells cultured in low and high oxygen level in vitro." Scholarly Commons, 2012. https://scholarlycommons.pacific.edu/uop_etds/210.

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Background: In the bone marrow, hematopoietic and mesenchymal stem cells form a unique niche, in which oxygen tension is low. Hypoxia may have a role in maintaining stem cell capacity for self-renewal and multipotency. We have shown previously a positive influence of platelet-derived growth factors (PDF) on increase of multiplication rate of human mesenchymal stem cells cultured in normal atmosphere. Objective: The goal of this study is to examine effects of platelet-derived factors and thrombin on multiplication of adult human mesenchymal stem cells derived from bone marrow (hBMMSC) in a low

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39

年申 and Shen Nian. "In vitro and in vivo evaluation of iris pigment epithelial cells cultured on surface modified expanded-polytetrafluorethylene substrates as a potential therapeutic strategy for retinal degeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193403.

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Retinal degenerative diseases are diseases that may severely affect vision of people at different ages. These include retinitis pigmentosa (RP) and age-related macular degeneration (AMD). The current treatments for these diseases are limited. Since dysfunction and atrophy of the RPE are the key factors in the development of retinal degenerative diseases, transplantation of healthy retinal pigment epithelial (RPE) cells might be a promising therapeutic strategy. However, homologous RPE cells may lead to host immune rejection and harvesting autologous RPE cells may cause severe complications. Au

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40

Ellen, Apelqvist, and Olsson Malin. "Är laboratorieodlat kött gött?" Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-21268.

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Studien undersöker människors inställning till att äta laboratorieodlat kött samt hur produktionen i laboratorium påverkar klimatet jämfört med konventionell produktion. Vi vill förstå vilka faktorer som påverkar inställningen till att konsumera laboratorieodlat kött och vad som ligger bakom den. Tre fokusgrupper genomfördes med hjälp av en guide som utformades innan genomförandet. De tre grupperna var baserade på deltagarnas kosthållning, då det skulle finnas en blandning av olika kosthållningar representerade i grupperna. Vi valde att låta både köttätare och icke-köttätare delta för att se h

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41

Ortman, Robert L. "Sensory input encoding and readout methods for in vitro living neuronal networks." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44856.

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Establishing and maintaining successful communication stands as a critical prerequisite for achieving the goals of inducing and studying advanced computation in small-scale living neuronal networks. The following work establishes a novel and effective method for communicating arbitrary "sensory" input information to cultures of living neurons, living neuronal networks (LNNs), consisting of approximately 20 000 rat cortical neurons plated on microelectrode arrays (MEAs) containing 60 electrodes. The sensory coding algorithm determines a set of effective codes (symbols), comprised of different

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42

Vildhede, Anna. "In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-241376.

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The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. Accurate predictions of drug CL and DDI risk from in vitro data are therefore crucial in drug development. Liver CL depends on several factors including the activities of transporters involved in the hepatic uptake and efflux. The work in this thesis a

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Langan, Laura. "Fish intestinal cultures for ecotoxicological studies : in vitro and primary culture models." Thesis, University of Plymouth, 2017. http://hdl.handle.net/10026.1/9486.

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Ecotoxicity testing of chemicals for environmental risk assessment is an area where a high number of vertebrates are used across a variety of industrial sectors. The application of the 3Rs in toxicity testing using fish address both the ethical and societal concerns around this issue in addition to the increasing legislative requests for the incorporation of animal alternatives. This thesis aims to highlight the potential of 3D cell culture models to "bridge the gap" between in vitro and in vivo screening procedures for testing of chemicals with the potential to persist or bioaccumulate thereb

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Mendes, Anabela Lindo dos Santos. "Cultura in vitro de embriões imaturos em ameixeira europeia." Master's thesis, Universidade de Évora, 1997. http://hdl.handle.net/10174/12550.

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Foram colhidos semanalmente, desde os 7 aos 70 dias após a polinização (DAP), frutos de Prunus domestica cv. ‘Rainha Cláudia Verde' provenientes de polinização livre. Com o objectivo de obter plântulas, foram extraídos os óvulos e/ou embriões e os eixos embrionários e testados três meios de cultura base, adicionando ou não diferentes tipos de reguladores de crescimento (auxina, giberelina e citocinina) e amino-ácidos (caseína hidrolisada 500 mg/l), tendo-se também variado a concentração de sacarose (2 e 10%). Foi ainda testada a técnica de perfuração da testa do óvulo e a influência do frio (3

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45

Misiuta, Iwona E. "Characterization of the Dopaminergic Potential of the Human NTera2/D1 (NT2) Cell Line In Vitro." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001184.

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46

Aidoukovitch, Alexandra. "Effects of strontium on osteogenic capacity and proliferation of human periodontal ligament cells and osteoblasts." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19681.

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Strontium (Sr2+) är det aktiva ämnet i läkemedel som används för att reducera frakturrisken hos patienter som lider av osteoporos. På senare tid har Sr2+ kombinerats med olika biomaterial i syfte att gynna benbildning, emellertid är ämnet vagt studerat avseende effekten på parodontala vävnader. Trots omfattande användning, är verkningsmekanismer av Sr2+ inte helt klarlagda. Denna studie syftar därmed till att utvärdera effekten av Sr2+ på humana parodontalligament-celler (PDL-celler) och osteoblaster avseende proliferation och osteogen aktivitet. Odlade humana PDL celler och osteoblastcellinje

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47

Saleil, Véronique. "Développement "in vitro" des apex isolés à partir de deux espèces d'igname, Dioscorea alata et Dioscorea trifida." Montpellier 2, 1986. http://www.theses.fr/1986MON20091.

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48

Silva, Crysthiane Saveriano Rubião. "Apoptose precoce, proliferação celular sincrônica tardia e perfil de expressão de proteínas ao complexo esclerose tuberosa e às doenças renais policísticas durante tubulogênese in vitro." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-01082013-145925/.

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O complexo esclerose tuberosa (CET) e as doenças renais policísticas autossômica dominante (DRPAD) e autossômica recessiva (DRPAR) são doenças monogênicas associadas a cistogênese renal. Os produtos dos genes mutados nessas enfermidades, respectivamente tuberina e hamartina para CET, policistina-1 (PC1) e policistina-2 para DRPAD, e poliductina/fibrocistina para DRPAR, modulam proliferação, diferenciação, apoptose, crescimento e/ou migração celular. Neste estudo empregamos um sistema tridimensional de cultura de células IMCD para caracterizar os perfis de expressão dessas proteínas durante a t

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Shahabeddin, Lili. "Développement et caractérisation d'une "peau reconstruite" in vitro." Lyon 1, 1991. http://www.theses.fr/1991LYO1T026.

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Batista, Mariana Raposo. "Desenvolvimento de um sistema de cultura in vitro de células lúteas bovinas para estudar as interacções com embriões em co-cultura." Master's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2011. http://hdl.handle.net/10400.5/4325.

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Abstract:

Dissertação de Mestrado Integrado em Medicina Veterinária<br>O objectivo deste trabalho foi o desenvolvimento de um sistema de cultura in vitro de células lúteas bovinas, compatível com o sistema de cultura in vitro de embriões bovinos, para estudar as suas interacções, relevantes para o estabelecimento da gestação nos mamíferos. As células foram obtidas pela digestão de corpos lúteos (CL) pela colagenase, seguida de centrifugações em gradiente de Percoll® e centrifugações a velocidades decrescentes. Foram estudados os efeitos do estadio do CL do qual provêem as células lúteas, meio de c

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