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Dissertations / Theses on the topic 'In-Vitro Drug Release Etc'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

ZHOU, YING. "DETERMINATION OF in vitro DRUG RELEASE FROM WOUND DRESSINGS THROUGH AN ARTIFICAL WOUND MODEL." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1018614820.

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2

BISWAS, DEBLINA. "A BIORELEVANT IN VITRO MODEL TO CHARACTERIZE IN VIVO RELEASE OF BONE MORPHOGENETIC PROTEIN-2 (rhBMP-2)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4977.

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Biorelevant in vitro release/dissolution tests are designed to predict the in vivo behavior of a drug and are crucial in understanding its in vivo performance. Currently, there is no standardized compendial in vitro release testing methods or regulatory guidance’s for release/dissolution testing of implants due to their complex physiological locations.Furthermore, existing compendial methods do not capture the local release profile of ‘novel’ parenterals in physiological low fluid volume surrounding areas. Long acting and in situ forming implants with orthobiologic proteins and peptides have i

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3

SMITH, DENISE ANNE BUSH. "In vitro Characterization of Echogenic Liposomes (ELIP) for Ultrasonic Delivery of Recombinant Tissue-type Plasminogen Activator (rt-PA)." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1214234148.

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4

Hall, Jill S. "Development of an in vitro method to help predict in vivo behavior of controlled release products." View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-2/hallj/jillhall.pdf.

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5

Komurcu, Ramazan. "Tryptamine terminated 1st generation polyamide dendrimer synthesis and drug release /." Akron, OH : University of Akron, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1196653318.

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Thesis (M.S.)--University of Akron, Dept. of Chemical Engineering, 2007.<br>"December, 2007." Title from electronic thesis title page (viewed 02/25/2008) Advisor, Stephanie T. Lopina; Faculty readers, Bi-min Newby, Helen Qammar; Department Chair, Lu-Kwang Ju; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.

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6

Graham, M. "Studies on the in-vitro release of salicyclic acid from a polyethylene mineral oil gel." Thesis, De Montfort University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354361.

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7

Quigley, Karen Josephine. "Factors influencing formation and the in vitro drug release from pellets containing chitosan." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266848.

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8

Iyer, Sunil S. "A 'Biorelevant' Approach for Accelerated In Vitro Release and In Vitro-In Vivo Relationship of a Biodegradable, Naltrexone Implant." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1523.

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9

Tettey-Amlalo, Ralph Nii Okai. "In vitro release of ketoprofen from proprietary and extemporaneously manufactured gels." Thesis, Rhodes University, 2005. http://eprints.ru.ac.za/295/.

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10

Wang, Hezhong. "Chitosan-Cellulose Nanocrystal Polyelectrolyte Complex Particles: Preparation, Characterization, and In Vitro Drug Release Properties." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/40353.

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Polyelectrolyte complexes (PECs) between chitosan, a mucoadhesive, intestinal mucosal permeability-enhancing polysaccharide, and cellulose nanocrystals, rod-like cellulose nanoparticles with sulfate groups on their surface, have potential applications in oral drug delivery. The purpose of this research was to develop an understanding of the formation and properties of chitosan–cellulose nanocrystal PECs and determine their in vitro drug release properties, using caffeine and ibuprofen as model drugs. Cellulose nanocrystals were prepared by sulfuric acid hydrolysis of bleached wood pulp. Chitos

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11

Goldoozian, Seyedreza [Verfasser]. "In vitro-in vivo correlation and modelling of drug release for HPMC-based matrix tablets / Seyedreza Goldoozian." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1151881279/34.

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12

Chinnakavanam, Sundararaj Sharath Kumar. "Development of a Multilayered Association Polymer System for Sequential Drug Delivery." UKnowledge, 2013. http://uknowledge.uky.edu/cbme_etds/13.

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As all the physiological processes in our body are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the primary objective of this research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. This particular device was designed aimed at the treatment of periodontitis, a highly prevalent oral inflammatory disease that affects 90% of the world population. This condition is caused by bacterial biofilm on the teeth, resulting in

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13

Jeganathan, Selva. "Improving the Distribution and Retention of Drug Released From In Situ Forming Implants." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1582297937287646.

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14

Mu, Xiaohong. "In vitro characterisation of food effects on in vivo performance of a heterodisperse polysaccharide-based controlled drug delivery system in gastrointestinal tract." Thesis, University of Bath, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340927.

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15

Patel, Ravi Bhasker. "DEVELOPMENT OF A NOVEL COMBINED EXPERIMENTAL AND MODELING APPROACH TO CHARACTERIZE IN SITU FORMING IMPLANTS FOR INTRATUMORAL DRUG DELIVERY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1303727407.

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16

Booysen, Laetitia Lucretia Ismarelda Josephine. "The in vitro and in vivo pharmacokinetic parameters of polylactic-co-glycolic acid nanoparticles encapsulating anti-tuberculosis drugs / L.L.I.J. Booysen." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9106.

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Tuberculosis (TB) is an infectious, deadly disease, caused by Mycobacterium tuberculosis (M.tb). In 2010, there were 8,8 million incident cases of TB globally. South Africa currently has the third highest TB incident cases worldwide. In an attempt to address the challenges facing TB chemotherapy, among which frequent dosing and long duration of therapy resulting in poor patient compliance, a novel poly(DL-lactic-co-glycolic) acid (PLGA) nanoparticulate drug delivery system (DDS) encapsulating anti-TB drugs was developed. It is hypothesised that this nanoparticulate DDS will address the challen

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17

Kopechek, Jonathan A. "The Role of Acoustic Cavitation in Ultrasound-triggered Drug Release from Echogenic Liposomes." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318878799.

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18

Nayak, Atul. "Microneedle assisted percutaneous delivery of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/21705.

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Local anaesthetic drugs are usually administered as symptom relieving drug formulations for the treatment of pain in superficial skin extremities. The anaesthesia is delivered into skin tissues at the site of pain because of nociceptive receptors. Concerns that exist regarding local anaesthetic drug formulations are low drug encapsulation efficiency, polydispersity of colloidal formulations, chemical interactions of released local anaesthetic drug with skin proteins and bulk viscoelastic properties. Complimenting drug formulation characteristics are the desirable rates of controlled release of

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19

Holden, Christopher A. "MODIFIED PAMAM DENDRIMERS IN TUNABLE DRUG-DELIVERY SYSTEMS: A SUSTAINED-RELEASE DENDRIMER HYDROGEL FOR ANTI-GLAUCOMA DRUGS AND SURFACE-ENGINEERED MACROPHAGES AS NANOPARTICLE CARRIERS FOR TARGETED ANTI-CANCER THERAPY." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5038.

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Two specific drug-delivery applications were sought in this work using polyamidoamine (PAMAM) dendrimers. One drug-delivery system used a novel dendrimer hydrogel (DH) for sustained delivery of anti-glaucoma drugs. In this work, PAMAM G3.0 dendrimers were covalently bonded with poly(ethylene glycol) (PEG12000) molecules which were subsequently acrylated, resulting in photocurable DH conjugates. For pharmacological studies, DH were loaded with a solution of intraocular pressure lowering drugs, brimonidine and timolol maleate, and were characterized for in vitro release and ex vivo transport an

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20

Ditto, Andrew. "DNA-LPEI complexes encapsulated in LTP nanospheres as a non-viral gene therapy vector." Akron, OH : University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1165596983.

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Thesis (M.S.)--University of Akron, Dept. of Biomedical Engineering, 2006.<br>"December, 2006." Title from electronic thesis title page (viewed 12/31/2008) Advisor, Yang Yun; Committee members, Stephanie Lopina, Steven Schmidt; Department Chair, Daniel Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.

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21

Cui, Yong. "Enhanced Release of Lidocaine From Supersaturated Solutions of Lidocaine In A Pressure Sensitive Adhesive." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054210962.

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22

Staples, Bryant J. "Pharmacokinetics of Ultrasonically-Released, Micelle-Encapsulated Doxorubicin in the Rat Model and its Effect on Tumor Growth." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1844.pdf.

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23

Lee, Tak-yee. "Part 1: Computer aided dosage form design: theory and applications. Part 2: Kinetics and mechanism of captopril oxidation in aqueous solutions under controlled oxygen partial pressure /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011224445.

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24

Maccari, Flavia Lima Ribeiro [UNESP]. "Avaliação da atividade antiproliferativa in vitro, liberação, permeação e retenção cutânea in vitro e estabilidade de emulsões contendo (-)- Terpinen-4-OL." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/96248.

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Made available in DSpace on 2014-06-11T19:28:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-04-08Bitstream added on 2014-06-13T18:57:11Z : No. of bitstreams: 1 maccari_flr_me_arafcf.pdf: 1400540 bytes, checksum: 7bc406a11537837c7f75cdf60b68c782 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Universidade Estadual Paulista (UNESP)<br>O terpinen-4-ol é o principal componente da M. alternifólia, apresenta atividade antiinflamatória, antibacteriana e antifúngica; em estudos recentes in vitro a atividade antineoplásica para linhagens celulares de melanom

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25

Maccari, Flavia Lima Ribeiro. "Avaliação da atividade antiproliferativa in vitro, liberação, permeação e retenção cutânea in vitro e estabilidade de emulsões contendo (-)- Terpinen-4-OL /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/96248.

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Resumo: O terpinen-4-ol é o principal componente da M. alternifólia, apresenta atividade antiinflamatória, antibacteriana e antifúngica; em estudos recentes in vitro a atividade antineoplásica para linhagens celulares de melanoma (M14) foi demonstrada. O objetivo específico deste trabalho foi verificar a atividade farmacológica in vitro dos isômeros óticos (-) terpinen-4-ol e (+) terpinen-4-ol e do óleo de Melaleuca alternifolia em nove linhagens diferentes de células tumorais, incluindo a célula UACC-62 do melanoma que ainda não havia sido estudada, e a concentração eficaz para o desenvolvime

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26

Clogston, Jeffrey. "Applications of the lipidic cubic phase from controlled release and uptake to in meso crystallization of membrane proteins /." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117564268.

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Thesis (Ph.D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xxii, 352 p.; also includes graphics. Includes bibliographical references (p. 346-352). Available online via OhioLINK's ETD Center

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27

Clogston, Jeffrey. "Applications of the lepidic cubic phase: from controlled release and uptake to in meso crystallization of membrane proteins." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117564268.

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28

Hofsäss, Martin Andy [Verfasser], Jennifer [Akademischer Betreuer] Dressman, Jennifer [Gutachter] Dressman, and Werner [Gutachter] Weitschies. "In vitro release testing as an alternative to establishing bioequivalence of drug products in vivo / Martin Andy Hofsäss ; Gutachter: Jennifer Dressman, Werner Weitschies ; Betreuer: Jennifer Dressman." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://d-nb.info/1229989269/34.

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29

Reeff, Jonathan. "Development and evaluation in vitro and in vivo of injectable hydrolipidic gels with sustained-release properties for the management of articular pathologies." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209288.

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Future changes in the incidence and prevalence of OA are difficult to predict. As incidence and prevalence rise with increasing age, extending life expectancy will result in greater numbers with OA. Actually, usual therapeutic approaches are really restricted because of important side effects with long-term use. Therefore, there is a need to develop improved formulations which are well tolerated, biocompatible and biodegradable. Ideally, these new treatments should be able to deliver locally sufficient amount of anti-inflammatory or analgesic drugs into the site of arthritic inflammation while

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30

Rivera, Edgardo. "Affinity-Based Drug Delivery Devices and its Applications in the Modulation of Cellular Processes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1417792663.

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31

Arai, Daisuke. "Development of a stent capable of the controlled release of basic fibroblast growth factor and argatroban to treat cerebral aneurysms : In vitro experiment and evaluation in a rabbit aneurysm model." Kyoto University, 2019. http://hdl.handle.net/2433/244518.

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32

Forino, Andrew Stephen. "Determining Effects of the PAF-R and Anti-Hypertensive Drugs Mediated Microvesicle Particle Release in Modulating Anti-Tumor Response of Lung Cancer." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1590691151424173.

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33

Andrade, Diego Fontana de. "Nanocápsulas de núcleo lipídico : estudos de penetração cutânea e proposição de estratégias para a avaliação da liberação in vitro." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/94616.

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Neste trabalho foi avaliada a permeação/penetração cutânea in vitro (pele suína) de propionato de clobetasol nanoencapsulado incorporado em um semissólido, empregando células de difusão de Franz. A nanoencapsulação foi capaz de reduzir a quantidade de fármaco que penetra nas camadas da pele (estrato córneo, epiderme e derme) sem alterar a forma (distribuição percentual) como o propionato de clobetasol se distribui. A adequabilidade de diferentes membranas sintéticas (acetato de celulose, policarbonato e membrana de diálise) para a avaliação da liberação in vitro, empregando células de difusão

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34

Sherwood, Edward T. "Post-release rate of loss and emigration of juvenile red drum (Sciaenops ocellatus) stocked out-of-season in the Chassahowitzka National Wildlife Refuge, Florida." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000788.

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35

Agossa, Kevimy. "Implants formés in-situ pour le traitement des poches parodontales : évaluation in-vitro et in-vivo." Thesis, Lille 2, 2018. http://www.theses.fr/2018LIL2S037/document.

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La frequence elevee et les consequences considerables des maladies parodontales sur la qualite de vie orale et la sante generale font de ces pathologies une preoccupation de sante publique. Le developpement de traitements innovants est un moteur essentiel du progres dans la prise en charge de ces maladies. Ce travail s’interesse a l’utilisation d’agents antimicrobiens (non-antibiotiques) et anti-inflammatoires comme adjuvants au debridement mecanique des poches parodontales. Il est consacre a la mise au point et a l’optimisation d’une forme galenique appelee implant forme in-situ (IFIS), a bas

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36

Toy, Randall. "The Effect of Particle Size and Shape on the In Vivo Journey of Nanoparticles." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1396887959.

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37

Li, Xiaojian. "MULTI-COMPONENT MICROPARTICULATE/NANOPARTICULATE DRY POWDER INHALATION AEROSOLS FOR TARGETED PULMONARY DELIVERY." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/31.

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The aim of the work was to design, manufacture, and characterize targeted multi-component dry powder aerosols of (non-destructive) mucolytic agent (mannitol), antimicrobial drug (tobramycin or azithromycin), and lung surfactant mimic phospholipids (DPPC:DPPG=4:1 in molar ratio). The targeted dry powder for inhalation formulation for deep lung delivery with a built-in rationale of specifically interfering several disease factors of chronic infection diseases in deep lungs such as cystic fibrosis, pneumonia, chronic bronchitis, and etc. The dry powder aerosols consisting of selected chemical age

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38

Alves, Michele Campos. "Desenvolvimento e validação de métodos analíticos para o controle de qualidade de formas farmacêuticas contendo chá verde (Camellia sinensis) e estudos de liberação e permeação cutânea." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/5715.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-09-05T19:49:54Z No. of bitstreams: 1 michelecamposalves.pdf: 4465106 bytes, checksum: 619948227c4d2d419bdbeb66a9cad785 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-09-06T11:36:14Z (GMT) No. of bitstreams: 1 michelecamposalves.pdf: 4465106 bytes, checksum: 619948227c4d2d419bdbeb66a9cad785 (MD5)<br>Made available in DSpace on 2017-09-06T11:36:14Z (GMT). No. of bitstreams: 1 michelecamposalves.pdf: 4465106 bytes, checksum: 619948227c4d2d419bdbeb66a9cad785 (MD5) Previous issue date: 2

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39

Jacob, Dolly. "Investigation into reliability and performance of an implantable closed-loop insulin delivery device." Thesis, De Montfort University, 2014. http://hdl.handle.net/2086/11126.

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An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied for future clinical use. Investigations into the device material compatibility with insulin solution, assessed by monitoring insulin loss and degradant formation over a period of 31 days using RP-HPLC have shown that stainless steel and titanium are the most compatible materials. Polycarbonate contribu

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40

Yuh-Tyng, Huang. "A sustained-release formulation study on the hygroscopic drug (pyridostigmine bromide) and the investigation of in vitro/in vivo correlation characteristics." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0011-3001200714382300.

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41

HUNG-HSIN, HSU, and 許宏心. "In Vitro Drug Release from Electric-Field Responsive Polycaprolactone Nanoparticles." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/4zub9t.

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碩士<br>國立臺灣科技大學<br>材料科學與工程系<br>107<br>In this study, we prepared a biocompatible drug carrier model with electric-field response. First, we modified polycaprolactone diol’s terminal functional group to polycaprolactone diacrylate(PCLDA), which has been comfirmed by IR and NMR spectrum. Second, we used emulsion polymerization to synthesize the polycaprolactone nanoparticles with PCLDA and also labled with nile red via drug encapsulation. Using Zeta-sizer and DLS to explore particle size and potential changes under different concentration of SDS.Furthermore, a high loading efficiency 71% and high

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42

LungLi, Chan, and 李展榮. "In vitro and in vivo release of dinalbuphine sebacate extended release formulation: Effect of the oil ratio on drug release." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/h29q2a.

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43

Cook, Rebecca. "In-vitro testing of the influence of ethanol on the release rate of oral extended-release solid dosage forms." 2007. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.13454.

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44

Yang, S., X. Yin, C. Wang, et al. "Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile." 2014. http://hdl.handle.net/10454/10557.

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No<br>Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron radiation X-ray computed microtomography (SR-muCT) and a sensitive LC/MS/MS method. The purpose of this article is to introduce a powerful, non-invasive and quantitative technique for studying individual pellet microstructures and to investigate the relationship between the microstructure and drug release from

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45

Profeta, Martina. "Smart design and in vitro testing of nanoparticles for microenvironmentally-triggered extracellular drug release." Tesi di dottorato, 2017. http://www.fedoa.unina.it/12165/1/PhDThesisMartinaProfeta.pdf.

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In the field of nanotechnology, one of the most operative research areas is nanomedicine, which applies nanotechnology to highly specific medical interventions for the prevention, diagnosis and treatment of diseases. Currently, the major issue that nanomedicine needs to face is the smart design and production of nanoparticles (NPs) based drug delivery systems for cancer therapy. Highly efficient drug delivery based on nanoparticles could potentially reduce the drug dose needed to achieve therapeutic benefit, thus reducing the side effects associated with the systemic delivery of drugs, whit gr

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46

Domingues, Nabais Maria Teresa. "High-amylose carboxymethyl starch matrices for oral sustained drug-release : in vitro and in vivo evaluation." Thèse, 2013. http://hdl.handle.net/1866/10943.

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Les amidons non modifiées et modifiés représentent un groupe d’excipients biodégradables et abondants particulièrement intéressant. Ils ont été largement utilisés en tant qu’excipients à des fins diverses dans des formulations de comprimés, tels que liants et/ou agents de délitement. Le carboxyméthylamidon sodique à haute teneur en amylose atomisé (SD HASCA) a été récemment proposé comme un excipient hydrophile à libération prolongée innovant dans les formes posologiques orales solides. Le carboxyméthylamidon sodique à haute teneur en amylose amorphe (HASCA) a d'abord été produit par l'éthérif

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47

Smith, E. W., and J. M. Haigh. "In vitro systems for the assessment of drug release from topical formulations and trans-membrane permeation." 1989. http://hdl.handle.net/10962/d1006628.

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Numerous experimental methods have been developed to investigate drug release from vehicles and the percutaneous absorption of topically applied chemicals. The objective of this research is often to find correlation between laboratory results and the transdermal absorption experienced by living subjects so that in vivo experimentation may be curtailed. In many instances, the diverse experimental techniques tend to obscure absorption-controlling factors and complicate inter study comparisons, rather than clarify the complex transdermal absorption process. Moreover, lack of agreement between res

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48

Ahmed, Gamal [Verfasser]. "Effect of drug physicochemical properties on the release from liposomal systems in vitro and in vivo / Gamal Ahmed." 2009. http://d-nb.info/993152082/34.

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49

Silva, Rita Afonso Gomes Sobral da. "Simulation of restricted swelling and its influence on drug release in PLGA formulations for in vitro test development." Master's thesis, 2014. http://hdl.handle.net/10451/39274.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>The design of alternative strategies to deliver drugs has gained increasing attention in the past decades. When it comes to the parenteral administration route, one can state that this is the most effective form of delivery for active drug substances, especially when their bioavailability is limited by an extensive first pass metabolism effect or with a narrow therapeutic index (Goel 2014). The development of parenteral controlled release systems has been mainly based on the in

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Ahmed, Iman Saad. "In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system." Thesis, 2002. http://hdl.handle.net/1957/30202.

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This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for swelling and dissolution properties using riboflavin as a model drug. Different shapes and sizes of GRDs were tested in dogs to study the gastric retention potential of these devices. The effect of the device on food emptying from the stomach in dogs was also in

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