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Journal articles on the topic 'In-Vitro Drug Release Etc'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Qaiser, Rasheed* Ghulam Razaque Ghulam Musatafa Shahwani Noman ul Haq Nisar Ahmed Shahwani Shafi Muhammad. "FORMULATION OF CONTROLLED RELEASE DRUG DELIVERY OF LORNOXICAM." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 2933–38. https://doi.org/10.5281/zenodo.892233.

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The aim of the present work was to develop controlled release matrix tablets of Lornoxicam using polymers such as carbopol, Eudragit RS100 and ethyl cellulose as carriers in various concentrations. Matrix tablets were prepared by direct compression method. Prepared formulations were subjected to various evaluation parameters like hardness, friability, thickness, % drug content, weight variation etc. In-vitro dissolution studies were carried out for 12 hrs. The tablets were subjected to in-vitro drug release in 1.2 pH for first 2 hrs then followed by 6.8 pH phosphate buffer for next 10 hrs and

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Karim, Samira, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 157–62. http://dx.doi.org/10.3329/bpj.v18i2.24315.

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This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected t

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Archana, S. Magdum* Y. R. Hundekar Dr. R. M. Chimkode. "NIOSOMES: A PROMISING VESICULAR DRUG DELIVERY SYSTEM FOR TUBERCULOSIS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 04, no. 08 (2017): 2710–23. https://doi.org/10.5281/zenodo.885339.

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<em>The drug ethambutol HCl is one of the first line antitubercular agent available in tablet form used in the treatment of pulmonary tuberculosis disease, for long term therapy but according to researcher the drug shows poor absorptivity in presence of food when administered orally & required higher dose of about 25mg/kg, also has short half life i.e.2-4 hrs., so to well utilization of drug as well as to minimize the side effects, there should have to modify the formulation in other suitable dosage form, like vesicular drug delivery system, in which incorporating the drug into system in t

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Mamidi, Upendar, and Priya Darsini Chowdavarapu Rukmini. "Formulation and In-vitro Evaluation Of Sustained Release Tablets Of Bosentan." AMERICAN JOURNAL OF PHARMTECH RESEARCH 12, no. 2 (2022): 42–60. https://doi.org/10.5281/zenodo.6659380.

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Bosentan is a dual endothelin receptor antagonist important in the treatment of pulmonary artery hypertension (PAH). It is licensed in the United States, the European Union and other countries by Actelion Pharmaceuticals for the management of PAH under the trade name Tracleer®. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. The aim of the present study was to develop sustained release formulation of Bosentan to maintain constant therapeutic levels of

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Begum, M. Yasmin, and Ali Alqahtani. "Characterization of bilayered matrix-type mucoadhesive buccal films containing tizanidine hydrochloride and piroxicam." Tropical Journal of Pharmaceutical Research 20, no. 11 (2021): 2241–48. http://dx.doi.org/10.4314/tjpr.v20i11.1.

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Purpose: To formulate and characterize tizanidine hydrochloride (TZN) and piroxicam (PRX)-loaded bilayer mucoadhesive buccal films with an intention to improve the bioavailability and patient compliance in pain management.Methods: Bilayer buccal films were prepared by solvent evaporation technique using hydroxypropyl methylcellulose (HPMC) 15cps and polyvinylpyrrolidone (PVP K30 as immediate release (IR) layer forming polymers and HPMC K15 M, PVP K 90 along with various muco adhesive polymers (Carbopol P934, sodium alginate, etc), as sustained release (SR) layer forming polymers. The prepared

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P, Phadatare Suvarna, Kurumkar Pritish P, Wanegaonkar Anjali M, and Jadhav Varsha M. "Lipid Nanoemulgel Therapy for the Treatment of Keratoconjunctivitis Sicca: Cyclosporine Formulation Characterization and In-vitro Evaluation." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 709–13. http://dx.doi.org/10.25258/ijddt.14.2.16.

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Nanoparticulate carrier systems play a significant part in enhancing ocular bioavailability. Emulgels are a potential new delivery method for the administration of lipophilic drugs like cyclosporine A (CsA). In the present research work, CsA, the immunomodulatory drug with a wide safety profile, has been formulated into nanoemulgel for treating vision-threatening ocular surface disorder viz. Keratoconjunctivitis sicca. The objective of this study was to prepare lipid-based nanoemulsion gel of CsA aiming to prolong corneal residence time and increase ocular bioavailability. Ophthalmic nanoemulg

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Subramanian, K., G. Harivignesh, and A. Jeevitha. "The in vitro release features of 5-Fluorouracil from tablets with chitosan, soy protein extract and chitosan-soyprotein extract blend as carriers and their thermal degradation characteristics." Research Journal of Chemistry and Environment 25, no. 7 (2021): 104–13. http://dx.doi.org/10.25303/257rjce10421.

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Natural polymers are finding widespread applications in drug delivery, scaffold fabrication, bio plastic production, food packaging, wound dressing etc. due to their availability, biodegradability, biocompatibility, renewable nature, ease of modification to achieve the desirable properties etc. In the present study, the commercially available soy protein extract (SPE), chitosan(CSN) and their physical blend(CSN-SPE) have been chosen as drug carrier matrices to campare their in vitro drug release features in simulated intestinal fluid for controlled release applications taking 5-fluorouracil (5

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Pal, Poonam, Shourya Pratap, and Shalini Singh. "FORMULATION AND IN-VITRO CHARACTERIZATION OF MUCOADHESIVE PATCHES OF ROOT EXTRACT OF ADENIUM OBESUM." International Journal of Pharmaceutical Sciences and Medicine 8, no. 6 (2023): 13–32. http://dx.doi.org/10.47760/ijpsm.2023.v08i06.002.

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Patches are punched from a sheet that serves as the intermediate product. Oral mucosal medication delivery alternatives to tablets have been studied, including polymers like cellulose etc. can be used to create mucosal patches. The present research was based on the development and in-vitro characterization of mucoadhesive patches of root extract of Adenium obesum utilizing different polymers. Adenium obesum (fresh roots) was obtained from the Unnao region. Eudragit L-100, Propylene glycol, Tween 80, Methanol, Ethanol and HPMCK 4M & HPMCK 15M were purchased from the local market. The initia

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PANDEY, PANKAJ KUMAR, and ASHISH KUMAR PARASHAR. "ORMULATION, CHARACTERIZATION AND EVALUATION OF LIPOSOMAL HYDROGEL FOR THE TREATMENT OF ANTIBIOTIC RESISTANT PROPIONIBACTERIUM ACNE." Current Research in Pharmaceutical Sciences 11, no. 2 (2021): 65–71. http://dx.doi.org/10.24092/crps.2021.110204.

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This work aimed to prepare and evaluate the topical liposomal hydrogel to treat antibiotic-resistant propionic bacterium acne. Nadifloxacin-loaded liposomes were prepared by thin-film hydration technique. Nadifloxacin, soya lecithin, cholesterol were dissolved in a mixture of chloroform and taken in different levels, and liposomes were prepared. The prepared liposomes were evaluated for in-vitro drug release. Formulation F2 was the highest percentage entrapment of 71±1.50% and released 58.12±1.2% of the drug in 6hrs. Minocycline hydrochloride-based hydrogel was prepared using the methylcellulo

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Das, Utpal, Shimul Halder, Abul Kalam Lutful Kabir, Harun Or Rashid, and Abu Shara Shamsur Rouf. "Development and in vitro Evaluation of Sustained Release Matrix Tablets of Indapamide from Methocel® K15 MCR and K100 LVCR." Dhaka University Journal of Pharmaceutical Sciences 10, no. 2 (2012): 87–92. http://dx.doi.org/10.3329/dujps.v10i2.11785.

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Indapamide, a low-dose thiazide-type diuretic, is used for the treatment of essential hypertension. In this study, we developed an indapamide sustained release formulation using Methocel K15 MCR (a modified hydroxypropyl methylcellulose), Methocel K100 LVCR (a modified hydroxypropyl methylcellulose), magnesium stearate, talc and starch 1500 by direct compression. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity etc. The tablets were subjected to thickness, weight variation test, hardness, friability and

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Kabir, Abul Kalam Lutful, Shimul Halder, Madhabi Lata Shuma, and Abu Shara Shamsur Rouf. "Formulation Development and in vitro Evaluation of Drug Release Kinetics from Sustained Release Aceclofenac Matrix Tablets using Hydroxypropyl Methyl Cellulose." Dhaka University Journal of Pharmaceutical Sciences 11, no. 1 (2012): 37–43. http://dx.doi.org/10.3329/dujps.v11i1.12485.

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The objective of the present study was to develop a once-daily sustained release matrix tablet of Aceclofenac using hydroxypropyl methyl cellulose (Methocel K 100M CR) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. The tablets were prepared by direct compression method. The powder blends were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity and drug content etc. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in vitro

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Supraja, Bommala, and Saritha Mulangi. "An updated review on pharmacosomes, a vesicular drug delivery system." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 393–402. http://dx.doi.org/10.22270/jddt.v9i1-s.2234.

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Novel drug delivery system mainly consents about achieving the targeted concentration to release the drug at targeted site by using carrier system, altering the structure and microenvironment around the drug. Especially drugs which are having narrow therapeutic window are difficult to formulate, with the advantage of novel drug delivery systems like particulate, polymeric carrier, macromolecular and cellular carriers. They are used to reduce complications as well as release the drug in a determined fusion at targeted site. In vesicular drug delivery system drug binds covalently to the lipid mo

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Garude, Niket N., and Rachel B. Geevarghese. "Design and Characterization of Nanostructure Lipid Carrier for Transdermal Delivery of Pioglitazone." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 4 (2018): 4185–95. http://dx.doi.org/10.37285/ijpsn.2018.11.4.6.

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Nanostructure Lipid Carrier (NLC) is one of the lipid-based drug delivery systems that are used as carrier for delivery of drugs. NLC are composed of mixture of solid lipid and liquid lipid, which form imperfect type of lipid matrix with improved drug loading capacity, drug release profile and stability. The aim of the present study was to develop and characterize nanostructure lipid carrier for transdermal delivery of pioglitazone (PZ) to overcome the problems related with oral route of administration and to improve systemic availability. NLC’s were prepared by high-speed homogenization metho

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., Komal, Ujjwal Nautiyal, Ramandeep ,. Anita Devi Singh, and Anita Devi. "Primary and Novel Approaches in Colon Targeted Drug Delivery System: A Review." Indian Journal of Pharmaceutical and Biological Research 3, no. 02 (2015): 37–57. http://dx.doi.org/10.30750/ijpbr.3.2.5.

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Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoeabiasis , colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). The colon specific drug delivery system (CDDS) should be capable of protecting the drug en route to the colon i.e. drug release and absorption should not occur in the stomach as well as

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E., Sathish Reddy Meesala. Srinivasa Rao and Mohammed Ibrahim. "FORMULATION AND IN VITRO, IN VIVO EVALUATION OF CEFADROXIL CONTROLLED GASTRORETENTIVE DRUG DELIVERY SYSTEM." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2139–50. https://doi.org/10.5281/zenodo.836461.

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Introduction: Cefadroxil is a first-generation cephalosporin and is very effective against Gram positive and Gram negative infections. Cefadroxil is an antibiotic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional Cefadroxil tablets produce rapid and relatively high peak blood level and require frequent administration to keep the plasma drug level at an effective range. The present study was carried out with an objective of preparation and in vivo evaluation of floating tablets of using Cefadroxil as a model drug using Eudragit polymers to impro

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Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,

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Ujjwal, Kukreti, Nainwal Nidhi, Ale Yogita, et al. "Release Kinetic of Sustained Release Matrix Tablet of Linezolid Containing Polymer Blend." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1479–84. http://dx.doi.org/10.25258/ijpqa.15.3.60.

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Tuberculosis (TB) is a bacterial infection mainly affecting the lungs. TB is a major health problem worldwide and the occurrence of extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB) offers considerable hurdles to effective treatment and disease management. The growth of treatment-resistant Mycobacterium TB strains has prompted the investigation of alternate therapeutic techniques, including the application of sustained drug delivery. Sustained-release drugs reduce the need for frequent dosing can extend the effects of linezolid by 8 to 12 hours, thus improving the pati

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Pallerla, Dharmender, Sreekanth Reddy Obireddy, Suman Banoth, and Sunkari Jyothi. "Development of polymeric microbeads-intercalated with montmorillonite nanoclay and silver nanoparticles for controlled release of levofloxacin, an antibacterial drug." Research Journal of Chemistry and Environment 26, no. 11 (2022): 119–29. http://dx.doi.org/10.25303/2611rjce1190129.

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Controlled release drug carriers have gained significant interest in recent years due to their potential to produce greater therapeutic success. To address this need, the study presents the fabrication of sodium alginate/poly(vinylpyrrolidone-co-vinyl acetate) microbeads intercalated with montmorillonite (MMT) clay and silver nanoparticles for the controlled release of levofloxacin by a simple ionotropic gelation technique. The prepared beads were characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (X-RD), differential scann

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Ogbonna, Josephat I., Lydia O. Ugorji, Chekwube C. Ezegbe, et al. "Influence of pH on the release of a once daily formulation of ciprofloxacin tablets prepared with different polymers." Tropical Journal of Pharmaceutical Research 22, no. 3 (2023): 469–76. http://dx.doi.org/10.4314/tjpr.v22i3.2.

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Purpose: To study the release behaviour of ciprofloxacin hydrochloride tablet matrices prepared with different polymers in dissolution media of different pH. Methods: Different formulations of slow-release matrix tablets of ciprofloxacin hydrochloride were prepared with polymers, namely, ethyl cellulose (Etc), hydroxyethyl cellulose (Hec), hydroxypropyl methylcellulose (Hpc), and Eudragit® L-100 (Eud) using matrix embedding technique. The matrix tablets were characterized and studies of their dissolution profiles were studied in 0.1 N HCl (pH 1.2) and in simulated intestinal fluid (excluding e

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Deshmukh, Aishwarya V., Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." Der Pharma Chemica 15, no. 6 (2023): 4. https://doi.org/10.5281/zenodo.13353444.

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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time

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Aishwarya, V. Deshmukh, Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." DER PHARMA CHEMICA 15, no. 6 (2023): 4. https://doi.org/10.4172/0975-413X.15.6.142-146.

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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time

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Satapathy, Bhabani Sankar, Ladi Alik Kumar, Gurudutta Pattnaik, and Binapani Barik. "Lomustine Incorporated Lipid Nanostructures Demonstrated Preferential Anticancer Properties in C6 Glioma Cell Lines with Enhanced Pharmacokinetic Profile in Mice." Acta Chimica Slovenica 68, no. 4 (2021): 970–82. http://dx.doi.org/10.17344/acsi.2021.6977.

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Effective treatment of glioma still stands as a challenge in medical science. The work aims for the fabrication and evaluation of lipid based nanostructures for improved delivery of lomustine to brain tumor cells. Experimental formulations (LNLs) were developed by modified lipid layer hydration technique and evaluated for different in vitro characteristics like particle size analysis, surface charge, surface morphology, internal structure, in vitro drug loading, drug release profile etc. Anticancer potential of selected LNLs was tested in vitro on C6 glioma cell line. Electron microscopic stud

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Wathore, Sandeep Ashokrao. "Formulation and In-Vitro Evaluation of Buclizine Buccoadhesive Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 137–44. http://dx.doi.org/10.22270/jddt.v9i4-a.3430.

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Buclizine is an antihistamine that is used to treat motions sickness, especially to prevent and treat symptoms such as abdominal pain, dizziness, nausea, vomiting, headaches, etc. It may also be used either alone or in a combination with other medicines for the treatment of hay fever and other allergic conditions. These dosages form make close contact with buccal mucosa, avoid first- pass metabolism, increase absorption and patient compliance, results in an enhanced drug bioavailability. Buccal adhesive tablets were prepared by direct compression. Carbopol 940 and Sodium Alginate was used in d

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Auel, Tobias, Linus Großmann, Lukas Schulig, Werner Weitschies, and Anne Seidlitz. "The EyeFlowCell: Development of a 3D-Printed Dissolution Test Setup for Intravitreal Dosage Forms." Pharmaceutics 13, no. 9 (2021): 1394. http://dx.doi.org/10.3390/pharmaceutics13091394.

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An in vitro dissolution model, the so-called EyeFlowCell (EFC), was developed to test intravitreal dosage forms, simulating parameters such as the gel-like consistency of the vitreous body. The developed model consists of a stereolithography 3D-printed flow-through cell with a polyacrylamide (PAA) gel as its core. This gel needed to be coated with an agarose sheath because of its low viscosity. Drug release from hydroxypropyl methylcellulose-based implants containing either triamcinolone acetonide or fluorescein sodium was studied in the EFC using a schematic eye movement by the EyeMovementSys

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Patel, Brijesh, and Hetal Thakkar. "Formulation Development of Fast Dissolving Microneedles Loaded with Cubosomes of Febuxostat: In Vitro and In Vivo Evaluation." Pharmaceutics 15, no. 1 (2023): 224. http://dx.doi.org/10.3390/pharmaceutics15010224.

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Febuxostat is a widely prescribed drug for the treatment of gout, which is a highly prevalent disease worldwide and is a major cause of disability in mankind. Febuxostat suffers from several limitations such as gastrointestinal disturbances and low oral bioavailability. Thus, to improve patient compliance and bioavailability, transdermal drug delivery systems of Febuxostat were developed for obtaining enhanced permeation. Cubosomes of Febuxostat were prepared using a bottom-up approach and loaded into a microneedle using a micromolding technique to achieve better permeation through the skin. O

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Akhilesh, Kumar, Shafaat Kausar, Kumar Singh Bimlendra, et al. "pH Sensitive Hydrogel Based Controlled Drug Delivery System for Oral Delivery of Famotidine." Pharmaceutical and Chemical Journal 12, no. 2 (2025): 22–33. https://doi.org/10.5281/zenodo.15606206.

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Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. A new pH responsive drug delivery system based on inter-polymeric hydrogels was developed for oral drug delivery of famotidine, the effe

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Mayur, Gokul Jayswal* Vasudev Sharma Adnan Siddiqui Raza Khan Shaikh Aaqueeb Ahmed Afsar Shaikh Qazi Majaz Ahamad Aejazuddin G. J. Khan. "Formulation and Evaluation of Sustained Release Tablet of an Anti-Diabetic Drug Vildagliptin Using Natural Polymer." International Journal in Pharmaceutical Sciences 1, no. 9 (2023): 457–68. https://doi.org/10.5281/zenodo.8394231.

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The goal of the current study was to formulate and evaluate vildagliptin sustained release tablets. It is thought to be a good medicine for the development of sustained release tablets because of its short biological half-life (1.5 h), which will allow it to continue to have a therapeutic effect for longer. Vildagliptin is a novel dipeptidyl peptidase-4 inhibitor family of oral antihyperglycemic medication. Materials and Method:  Sustain Release tablets were developed using a direct compression Method using various ratios of natural polymers (Gum). The preparations were examined for their

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Archana, B., Balla Vaishnavi, Kannayyagari Sindhu, Keesari Meena Goud, and D. Sai Poojitha. "Formulations and evaluations of repaglinide microspheres by ionotropic gelation technique." International Journal of Experimental and Biomedical Research 4, no. 1 (2025): 1–8. https://doi.org/10.26452/ijebr.v4i1.696.

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The current study aimed to formulate and evaluate Repaglinide microspheres utilizing the ionotropic gelation process, with sodium alginate, HPMC, and Carbopol as polymers and Cacl2 as a cross-linking agent. Because of its high biocompatibility and lack of toxicity, sodium alginate is a biodegradable natural polymer with considerable promise for therapeutic uses. Repaglinide microspheres offer desirable qualities. The ionotropic gelation approach allows for high medication integration in microspheres without harmful agents that have adverse side effects. The microspheres are tested for percenta

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Alven, Sibusiso, and Blessing Atim Aderibigbe. "The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment." Pharmaceutics 12, no. 12 (2020): 1212. http://dx.doi.org/10.3390/pharmaceutics12121212.

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Breast cancer is among the most common types of cancer in women and it is the cause of a high rate of mortality globally. The use of anticancer drugs is the standard treatment approach used for this type of cancer. However, most of these drugs are limited by multi-drug resistance, drug toxicity, poor drug bioavailability, low water solubility, poor pharmacokinetics, etc. To overcome multi-drug resistance, combinations of two or more anticancer drugs are used. However, the combination of two or more anticancer drugs produce toxic side effects. Micelles and dendrimers are promising drug delivery

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Kesharwani, Shivangi, Durgesh Kumari Gupta, and Mahesh Kumar Gupta. "In-Vitro Evaluation of Drug Release and Antioxidant Activity of Aloe Loaded Chitosan Nanoparticles." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 43–52. http://dx.doi.org/10.22270/jddt.v9i4.2979.

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Antioxidants play significant responsibility during the treatment of cancer and it’s adverse effects, because in the treatment of cancer by using chemotherapy, free radicals are generated and these free radicals accumulated in the body and cause damage, side effect (such as neurodegenerated disease, atherosclerosis, depression, leukemia, skin disease, diabetes etc.) and even death due to the biological consequence. So, antioxidant inhibits the generation of new and destroys previously present free radicals. A recent study was aimed for novel approach of herbal nanoparticles to get improved eff

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Kodalkar, Swapnil J., Rohan A. Khutale, Sachin S. Salunkhe, Sachin S. Mali, and Sameer J. Nadaf. "Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam." Indian Journal of Pharmaceutical and Biological Research 2, no. 01 (2014): 68–75. http://dx.doi.org/10.30750/ijpbr.2.1.11.

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In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected to preformulation studies comprising of micromeritic properties. The tablets were subjected to various studies like as physicochemical studies, in vitro drug release, kinetic studies, etc. FTIR studies shown there was no interaction between drug and

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Sharma, Diksha, Samriti Samriti, Mukul Sharma, Deepak Prashar, Namrata Namrata, and Heena Sharma. "Formulation and Assessment of Floating Sodium Alginate Beads of Analgesic Drug." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 1411–15. https://doi.org/10.35629/4494-090614111415.

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The main aim of this present research is to develop gastro retentive sustain release alginate beads of diclofenac sodium by ionotropic gelation method. Preparation of floating bead of diclofenac sodium was made by the dispersion of diclofenac sodium together with CaCl2 into solution of sodium alginate. In this study an attempt was done to prepare a controlled release sodium alginate beads comprised of diclofenac sodium drug. Produced beads were evaluated for encapsulation efficiency, swelling index, in- vitro dissolution studies etc.

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SALUNKHE, GOPAL, SOPAN NANGARE, PRATIKSHA DEVKAR, KETAN PATIL, PIYUSH BAFNA, and LAXMIKANT ZAWAR. "pH-RESPONSIVE INTERPENETRATING POLYMER NETWORK HYDROGEL MICROBEADS OF POLYACRYLAMIDE-G-GUM KONDAGOGU AND SODIUM ALGINATE FOR GASTROPROTECTIVE DRUG DELIVERY: IN VITRO-IN VIVO CHARACTERIZATIONS." Cellulose Chemistry and Technology 58, no. 7-8 (2024): 713–26. http://dx.doi.org/10.35812/cellulosechemtechnol.2024.58.65.

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The present work aims to design interpenetrating polymer network (IPN) mediated hydrogel microbeads of hydrolyzed polyacrylamide-g-gum kondagogu (H-pAAm-g-GK) and sodium alginate (SA) for pH-sensitive gastroprotective drug delivery of diclofenac sodium (DS). In brief, the pAAm-g-GK was prepared using microwave irradiation, followed by conversion into a pH-sensitive polymer (H-pAAm-g-GK) using alkaline hydrolysis. Then, DS-loaded IPN microbeads were made utilizing an ionotropic gelation method using Ca+2 ions and glutaraldehyde (GA) as a crosslinking agent. After this, different characterizatio

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Tyagi Gajendra, Choudhary Suresh, and Kalra Naresh. "Formulation of microsponges of anti-fungal drugs and their pharmacokinetic and in vitro analysis." Tropical Journal of Pharmaceutical and Life Sciences 11, no. 2 (2024): 24–44. http://dx.doi.org/10.61280/tjpls.v11i2.158.

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Microsponges are uniform, spherical, porous polymeric microspheres having myriad interconnected voids of particle size range 5-300 μm. These microsponges have the capacity to entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens and anti-infective, etc. and then release them onto the skin over a time in response to a trigger. Microsponge Delivery System (MDS) can be used to resolve the problem associated with these conventional approaches. The drug entrapped microsponges can be incorporated into a formulated product, such as a gel, cream, liquid o

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Athmakur, Harikiran, and Anand Kumar Kondapi. "CARMUSTINE LOADED LACTOFERRIN NANOPARTICLES DEMONSTRATES AN ENHANCED ANTIPROLIFERATIVE ACTIVITY AGAINST GLIOBLASTOMA IN VITRO." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 234. http://dx.doi.org/10.22159/ijap.2018v10i6.28004.

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Objective: Despite sophisticated treatment regimens, there is no significant improvement in the mortality rates of glioblastoma due to insufficient dosage delivery, reoccurrence of tumors, higher systemic toxicity, etc. Since brain endothelial cells and glioblastoma cells express lactoferrin receptors, a target-specific drug delivery vehicle was developed using lactoferrin itself as a matrix, into which carmustine was loaded. The objective was to use carmustine loaded lactoferrin nanoparticles (CLN) to achieve higher therapeutic efficacy and target specificity compared to free carmustine.Metho

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Soukhya, Joshi G. Saqib Akram Wani Sushma Touseef Vanishree K. H. Doddayya Ayesha Sultana* Pradnya B. Patil Sarfaraz MD. "Formulation And In-Vitro Evaluation of Compression Coated Core Tablets of Metronidazole for Colon Specific Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2380–86. https://doi.org/10.5281/zenodo.15421663.

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The study aimed to formulate and evaluate colon-specific compression-coated core tablets of Metronidazole for treating intestinal amoebiasis, focusing on improved efficacy, reduced dosing frequency, and enhanced patient compliance. Core tablets were prepared using wet granulation method with PVP K-30 as a binder and sodium starch glycolate as a disintegrant. Compression-coated tablets utilized varying ratios of chitosan and Carbopol 934P polymers. Granules were assessed for physical properties like angle of repose, bulk density, compressibility index, etc.  Tablets underwent tests for wei

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Ossipov, Dmitri A., Mads Lüchow, and Michael Malkoch. "Differentiating Co-Delivery of Bisphosphonate and Simvastatin by Self-Healing Hyaluronan Hydrogel Formed by Orthogonal “Clicks”: An In-Vitro Assessment." Polymers 13, no. 13 (2021): 2106. http://dx.doi.org/10.3390/polym13132106.

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Due to its unique properties resembling living tissues, hydrogels are attractive carriers for the localized and targeted delivery of various drugs. Drug release kinetics from hydrogels are commonly controlled by network properties and the drug-network interactions. However, and simultaneously, the programmable delivery of multiple drugs with opposing properties (hydrophilicity, molecular weight, etc.) from hydrogels with determined network properties is still challenging. Herein, we describe the preparation of injectable self-healing hyaluronic acid (HA) hydrogels that release hydrophobic simv

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Menkudale, Amruta, Pankaj Khuspe, Kishor Otari, Manisha Khemnar, and Vaishali Kulkarni. "An Updated Review on Applications of Natural Polymers in Sustained Release Drug Delivery System." Journal of Advances in Pharmacy Practices (e-ISSN: 2582-4465) 2, no. 1 (2020): 45–49. https://doi.org/10.5281/zenodo.3674633.

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<em>Sustained release drug delivery system is area of interest for formulation scientists in pharmaceutical industry because of advantage of administering a single dose of a drug that is released for an extended period of time instead of numerous doses. SDDS have various advantages like it optimize biopharmaceutical, pharmacokinetic and pharmacodynamic properties of drug in order to increase its use, reduce adverse effects, cure the disease, decrease the frequency of administration and thus, increase the patient compliance, increase safety margin of potent drugs, reduce healthcare costs etc. T

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Padmaja, B., and S. Shobha Rani. "Formulation development and characterization of Lecarnidipine hydrochloride niosomal transdermal patches." Journal of Drug Delivery and Therapeutics 13, no. 8 (2023): 100–109. http://dx.doi.org/10.22270/jddt.v13i8.5942.

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The bioavailability of Lercanidipine Hydrochloride (LCP) is about 44% and half-life of the drug is about 4.6 hours. LCP due to its low therapeutic dose range of 2.5 to 20mg and substantial biotransformation in liver becomes it ideal molecule in development of transdermal therapeutic system. The primary objective of the present research work was to develop Niosomal transdermal patch (NP) of Lecarnidipine. The LCP nanoparticles were prepared by solvent evaporation method and the optimized Nanoparticles formulation has shown 225nm particle size with a polydispersity index (PDI) of 0.120. LCP patc

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Patel, B. P., and D. M. Patel. "DESIGN OF DUAL RELEASE DRUG DELIVERY SYSTEM OF ROXYTHROMYCIN AND AMBROXOL HYDROCHLORIDE." INDIAN DRUGS 53, no. 10 (2016): 27–33. http://dx.doi.org/10.53879/id.53.10.10582.

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Upper respiratory tract infections (URTIs) are illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx. Roxithromycin (macrolide antibiotic) and ambroxol HCl (mucolytic) are used for this treatment. The dual release system of roxythromycin and ambroxol HCl was successfully prepared by bi-layer tablet approach for management of URTI. Quick release of roxithromycin was achieved by using disintegrants and slow release of ambroxol HCl was achieved by using matrix formulation of drug with HPMC K4M and ethyl cellulose. The 32 full factorial

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Hariharan, Gayathri, and Priyanka Sinha. "BIODEGRADABLE POLYMER: A NOVEL PHARMACEUTICAL CARRIER FOR SUSTAINED RELEASE OF METRONIDAZOLE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 136. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.19903.

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Objective: To optimize and evaluate the formulation of metronidazole (MT)-loaded chitosan microspheres and to investigate the efficiency of biodegradable polymer in developing sustained release formulation of MT to prolong the action of drug.Methods: MT microspheres were prepared using emulsion cross-linking method. Polymer-drug compatibility study was done using Fourier transform infrared. Physical characteristics were evaluated by particle size,SEM, flow properties etc. In vitro studies for evaluating drug release for MT-loaded chitosan microspheres were done by dissolution study.Results: Pa

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Radu (Dușman), Ramona-Daniela, and Doina Drăgănescu. "Present and Future of ZrO2 Nanostructure as Reservoir for Drug Loading and Release." Coatings 13, no. 7 (2023): 1273. http://dx.doi.org/10.3390/coatings13071273.

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Extensive research has been conducted on ZrO2 nanostructures due to their favorable biocompatibility, low toxicity, and promising prospects in various biomedical applications. They can be used as drug carriers, facilitating the administration of therapeutic substances into the body while enhancing their effectiveness and safety. This is achieved by regulating the timing, location, and rate at which drugs are released within the body. Several factors can influence the effectiveness of drug loading onto ZrO2 nanostructures, such as the physicochemical characteristics of the drugs, the surface pr

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Kaur, Lovleen, Rajni Bala, Neha Kanojia, Manju Nagpal, and Gitika Arora Dhingra. "Formulation Development and Optimization of Fast Dissolving Tablets of Aceclofenac Using Natural Superdisintegrant." ISRN Pharmaceutics 2014 (May 8, 2014): 1–10. http://dx.doi.org/10.1155/2014/242504.

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The current research work involves preparation of fast dissolving tablets of Aceclofenac by direct compression method using different concentrations of Lepidium sativum mucilage as natural superdisintegrant. A two-factor three-level (32) factorial design is being used to optimize the formulation. Nine formulation batches (D1–D9) were prepared accordingly. Two factors as independent variables (X1-amount of β-cyclodextrin and X2-amount of Lepidium sativum mucilage) were taken with three levels (+1,0,-1). The levels of two factors were selected on the basis of preliminary experiments conducted an

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Kulkarni, Gururaj S., Prabhansh P. Chaudhary, and Shivakumar Swamy. "Formulation and Evaluation of Sustained Release Floating Tablets of an Antihypertensive Diltiazem." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 5 (2017): 3844–52. http://dx.doi.org/10.37285/ijpsn.2017.10.5.5.

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The aim of the present study was to develop and evaluate sustained release floating tablets of Diltiazem hydro-chloride, an antihypertensive agent. The sustained release floating tablets were prepared by direct compression method and formulated using different polymer combinations, formulations such as F1 to F9. Natural polymer Sodium alginate and synthetic polymer HPMC K4M were used. Developed formulations were evaluated for the pre compression parameters i.e., drug- excipients compatibility by FTIR, bulk density, compressibility, and angle of repose etc. Post compression parameters i.e. weig

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Satyajit, Panda, Mishra Bibaswan, and Behera Swayamprava. "Bi-Layer Tablets: An Emerging State of Art Technology in Dosage Form Design." Journal of Advances in Nanotechnology and its Applications 3, no. 2 (2021): 1–14. https://doi.org/10.5281/zenodo.5515151.

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<em>Despite significant advancements in dosage form design, oral route still remains the most favoured route of drug administration. Even now-a-days tablets have got more attention compared to other dosage forms because of simple, inexpensive, greater stability and most suitable nature of tablets. More recently major considerations in tablet sector have been focused on development of controlled and immediate release drug delivery systems. Many pharmaceutical manufacturers are giving more emphasis to bi-layer tablet sector now a day, because of several advantages like extension of patent, impro

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Kundan Rajendra Mahajan, Ashish Prakash Gorle, and Vijay Sanjay Khalane. "Overview on pulsatile drug delivery system." International Journal of Science and Research Archive 5, no. 2 (2022): 110–18. http://dx.doi.org/10.30574/ijsra.2022.5.2.0067.

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Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal

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Mayuri, Desai Divya Shah Jayant Sarolia Pranav Shah* Jaimini Gandhi. "FORMULATION AND EVALUATION OF EZETIMIBE LOADED SOLID LIPID NANOPARTICLES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 661–73. https://doi.org/10.5281/zenodo.1036561.

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Ezetimibe is an anti hyperlipidemic drug which has poor aqueous solubility (0.00846 gm/L) and low bioavailability (35%). The SLNs were prepared using high speed homogenization technique. Glyceryl monostearate (GMS) and Poloxamer 188 were employed as lipid carrier and surfactant respectively. A two factor, three level (32) full factorial design was applied to study the effect of independent variables i.e. amount of GMS (X 1) and amount of Poloxamer 188 (X 2) on dependent variables i.e. Particle size (Y 1 ), % Entrapment efficiency (Y2) and % Cumulative drug release at 24hour (Y3). Particle size

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Sahil, N. Kamble*1 Radhika S. Subhedar2 Nilesh Chougale3. "Preparation And Evaluation Oral Buccal Patches Of Ambroxol Hydrochoride As Mucolytic." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3478–93. https://doi.org/10.5281/zenodo.13349354.

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This study aims to develop and evaluate oral buccal patches containing Ambroxol Hydrochloride (AH) for its mucolytic effects. Buccal patches offer advantages such as bypassing first-pass metabolism, sustained drug release, and improved patient compliance. Buccal patches were prepared using the solvent casting method with various polymers including Hydroxypropyl methylcellulose (HPMC), methyl alcohol, citric acid, etc were incorporated as plasticizers to enhance flexibility. The formulated buccal patches demonstrated uniform thickness and weight, satisfactory folding endurance, and appropriate

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Kailash, Sahu, Pathan Saman, Khatri Kapil, Upmanyu Neeraj, and Shilpi Satish. "Development, characterization, in vitro and ex vivo evaluation of antiemetic transdermal patches of ondansetron hydrochloride and dexamethasone." GSC Biological and Pharmaceutical Sciences 14, no. 3 (2021): 067–78. https://doi.org/10.5281/zenodo.4656134.

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The idea of delivering drugs through skin is old, as the use is reported back in 16<sup>th</sup> century B.C. The husk of the castor oil plant in water was placed on an aching head. Today the transdermal drug delivery is well accepted for delivering drugs to the systemic circulation. The aim of this study was to design a compound transdermal patches containing ondansetrone HCL and dexamethasone for the treatment of nausea and vomiting in case of chemotherapy and regular symptom of nausea and vomiting. In the present work, an attempt has been made to develop a matrix-type transdermal thera

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Qian, Xian-ling, Jun Li, Ran Wei, Hui Lin, and Li-xia Xiong. "Internal and External Triggering Mechanism of “Smart” Nanoparticle-Based DDSs in Targeted Tumor Therapy." Current Pharmaceutical Design 24, no. 15 (2018): 1639–51. http://dx.doi.org/10.2174/1381612824666180510094607.

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Background: Anticancer chemotherapeutics have a lot of problems via conventional Drug Delivery Systems (DDSs), including non-specificity, burst release, severe side-effects, and damage to normal cells. Owing to its potential to circumventing these problems, nanotechnology has gained increasing attention in targeted tumor therapy. Chemotherapeutic drugs or genes encapsulated in nanoparticles could be used to target therapies to the tumor site in three ways: “passive”, “active”, and “smart” targeting. Objective: To summarize the mechanisms of various internal and external “smart” stimulating fac

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