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Journal articles on the topic 'In vitro floating'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Rajeshwar, V. *. Vasudha Bakshi. "FORMULATION AND IN-VITRO EVALUATION OF EPROSARTAN FLOATING TABLETS." Journal of Pharma Research 8, no. 5 (2019): 354–59. https://doi.org/10.5281/zenodo.3236721.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he Eprosartan is a selective ACE-II blocking agent which is used in the treatment of hypertension. In this study Eprosartan Floating tablets were prepared by using different polymers like HPMCK4M, HPMCK15M, HPMCK100M and CARBOPOL and HPC. Fifteen formulations of floating tablets of Eprosartan were developed by direct compression technique. The F9 formulation was found to be best of all the trials. The best formulation F9 can successfully be employed as a controlled release floating drug delivery system. The floating tablets can

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2

Sharma, Rajesh Kumar, Naresh Kalra, Jayesh Dwivedi, G. Jeyabalan, and Gurpreet Singh. "Development, Characterization and bioavailability enhancement of oral floating sustained release beads containing Indomethacin." Indian Journal of Pharmaceutical and Biological Research 6, no. 04 (2018): 48–54. http://dx.doi.org/10.30750/ijpbr.6.4.10.

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The purpose of this research was to prepare and evaluate floating gastroretentive beads of Indomethacin an Non-steroidal anti-inflammatory agent for increased drug bioavailability. Floating beads were prepared by dripping Method using different polymers in varying ratios. The formulations were optimized on the basis of floating ability and in-vitro drug release. The floating beads were evaluated for micromeritic properties, entrapment efficiency, as well as in-vitro buoyancy study and drug release. Indomethacin was estimated in the formulation by using UV/Visible spectrophotometer (Shimazdu UV

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3

Singh, Km Akancha, Vivek Kumar Patel, and Abhishek Rai. "Formulation and Evaluation of Famotidine Gastroretentive Floating Tablet by Using Biopolymer." International Journal of Research and Review 9, no. 8 (2022): 21–30. http://dx.doi.org/10.52403/ijrr.20220803.

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HPMC K4M, HPMC K15M, and HPMC K100M polymers are used in this study to make floating tablets of famotidine hydrochloride. Drug Delivery systems that are floating in the stomach have a lower bulk density than gastric fluids, therefore they stay buoyant in the stomach for a lengthy period of time without impacting gastric emptying rate. In the treatment of gastroesophageal reflex disease (GERD) and peptic ulcer (PUD). Famotidine is a histamine H2 receptor antagonist (GERD). Famotidine is an excellent option for a floating drug delivery system because of its short half-life, brief time in the sto

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4

Jain, Nidhi, and Rahul Gupta. "Development and in vitro Evaluation of Floating Microparticles of Cimetidine." Current Research in Pharmaceutical Sciences 7, no. 1 (2017): 25–29. http://dx.doi.org/10.24092/crps.2017.070104.

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5

Salunkhe, Pranali Shivaji. "FORMULATION AND EVALUATION OF GASTRORETENTIVE TABLETS OF ANTIULCER DRUG." Asian Journal of Pharmaceutical and Clinical Research 9, no. 6 (2016): 48. http://dx.doi.org/10.22159/ajpcr.2016.v9i6.10360.

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ABSTRACTGastroretentive floating drug delivery system is utilised to target drug release in the stomach or to the upper part of intestine. Lansoprazole is proton pump inhibitor intended for oral administration used as antiulcer agent. The present investigation involved formulation and evaluation of Gastroretentive floating tablets of Lansoprazole for prolongation of gastric residence time with a view to deliver the drug at sustained and controlled manner in gastrointestinal tract. The tablets of Lansoprazole were prepared by direct compression method using gas generating agent and different po

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6

Singh, Satya Prakash, and Navneet Kumar Verma. "Formulation and Evaluation of Torsemide Granules (Sustained Release)." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 480–85. http://dx.doi.org/10.22270/jddt.v9i2-s.2581.

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The aim of study was to design development and optimize a controlled release system of Torsemide. to increase its bioavailability by increasing the residence time in the stomach without contact with the mucosa, and was achieved through the preparation of floating granules by melt granulation techniques. Torsemide; a loop diuretic used in the treatment of congestive heart failure and edema was chosen as the drug candidate to be formulated as gastro retentive multiparticulate system as it is a weakly basic drug with a short half life of 2-3 hrs. Gelucire 43/01 was selected as a lipid carrier in

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7

Clapa, Doina, Alexandru Fira, and Nirmal Joshee. "An Efficient Ex Vitro Rooting and Acclimatization Method for Horticultural Plants Using Float Hydroculture." HortScience 48, no. 9 (2013): 1159–67. http://dx.doi.org/10.21273/hortsci.48.9.1159.

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This article presents a new acclimatization method, ex vitro acclimatization in float hydroculture. This protocol ensures the ex vitro acclimatization of the plantlets obtained in vitro in the rooting stage or the ex vitro rooting and acclimatization of the shoots obtained in the multiplication stage. Our hydroculture method is different from the techniques of flotation hydroculture because no fertilizers or plant growth regulators or other biostimulators are used and water oxygenation by bubbling is not provided. Ex vitro rooting and acclimatization in one stage without an in vitro rooting st

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8

Gopaiah, K. Venkata, Ramya Teja Medarametla, J. N. Suresh Kumar, et al. "Advanced Granulation and Formulation Strategies for Histamine H2 Receptor Antagonists in Peptic Ulcer Disease Management." Journal of Neonatal Surgery 14, no. 10S (2025): 1000–1013. https://doi.org/10.63682/jns.v14i10s.6812.

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Present work seeks to formulate floating tablets of famotidine Hydrochloride employing HPMC K4M, HPMC K15M and HPMC K100M polymers. The bulk density of the floating drug delivery systems is lower than the gastric fluid density and therefore has the potential to be suspended in the gastric cavity for long durations of time although the rate of gastric emptying is unaffected. Famotidine is classified as a histamine H2 receptor antagonist and it is on the World Health Organization's Model List of Essential Medicines used for the treatment of peptic ulcer disease (PUD) and gastro oesophageal reflu

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9

Rathi, Jagdish, Mithun Bhowmick, Rahul Sharma, Sagar Panse, Rupal Pandit, and Sachin Gupta. "Development and In-vitro characterization of floating drug delivery system of ketoconazole." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 22–29. http://dx.doi.org/10.22270/jddt.v9i1.2153.

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The oral route is increasingly being used for the delivery of therapeutic agents because the low cost of the therapy and ease of administration lead to high level of patient compliances. Floating drug delivery system (FDDS) float in the gastric fluid and prolong GRT to obtain sufficient drug bioavailability, because of their lower bulk density compared to that of the aqueous medium. The aim of the present study is to prepare floating tablets as a delivery system for controlled release of Ketoconazole. Ketoconazole is a drug of choice in antifungal category and gives significant result. Floatin

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10

Gaikwad, V. D., V. D. Yadav, and P. D. Jadhav. "Formulation and Evaluation of Bilayer Floating Matrix Tablets For Captopril." International Journal of Current Pharmaceutical Review and Research 4, no. 2 (2013): 27–35. https://doi.org/10.5281/zenodo.12690415.

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The importance of the present investigation was to formulate a bilayer-floating tablet (BFT)for captopril using direct compression technology. The release layer contained captopril andvarious polymers such as HPMC-K15M, PVP-K30 and Carbopol 934p, alone or incombination with the drug. HPMC, K-grade and effervescent mixture of citric acid and sodiumbicarbonate formed the floating layer. The floating mechanism and in vitro dissolution studieswere carried out in a USP 23 apparatus 2 in simulated gastric fluid (without enzyme, pH 1.2).Final formulation released approximately 95% drug in 12 hrs in v

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11

Patel, Upasana J., Hitesh kumar A. Patel, Bhumika J. Limbachiya, and Mehzabeen Jhankhwala. "Formulation, development and optimization of gastroretentive floating pellets of febuxostat." Journal of medical pharmaceutical and allied sciences 11, no. 1 (2022): 4317–23. http://dx.doi.org/10.55522/jmpas.v11i1.2095.

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The aim of the study was to develop gastro retentive floating pellets of febuxostat used to treat gout condition which having low solubility and high bioavailability. The gastro retentive floating pellets of febuxostat were formulated using Gelucire 43/01 and ethyl cellulose as a sustain release polymer and microcrystalline cellulose as spheronizing agent by extrusion- spheronization technique. A 32 full factorial design was applied to investigate the effect of the two-independent variable, that is, ratio of Drug: Gelucire (X1) and ratio of Drug: ethyl cellulose (X2), on the dependent variable

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12

Tomer, Kajal, and Dilip Kumar Gupta. "FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE FLOATING MICROBALLOONS OF POORLY WATER-SOLUBLE DRUG DIACEREIN." International Research Journal Of Pharmacy 15, no. 5 (2021): 8–12. http://dx.doi.org/10.7897/2230-8407.1205134.

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The drug can be released in a controlled manner using a gastro retentive dosage type. The main focus on the novel technological advances in the floating drug delivery method for gastric retention. The preparation of diacerein micro balloon is done by solvent diffusion method, using acrylic polymer like Eudragit S 100 and HPMC K4 M. The various evaluation of the prepared floating microsphere like its % yield, drug entrapment efficiency, particle size in-vitro dissolution, buoyancy, was studied. The floating microsphere was found to be spherical and range from 85 μm - 192 μm. Whereas the buoyanc

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13

Bakshi, Vasudha, Swapna S., Deepa Kumari Choudhary, Ch Revanth, B. Sai KumarCh. Praveen, and Ch Praveen. "Design and characterization of metoprolol floating matrix tablet." Pharmaceutical and Biological Evaluations 4, no. 2 (2017): 118. http://dx.doi.org/10.26510/2394-0859.pbe.2017.18.

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Objective: The objective of the present research was to develop a matrix embedded floating tablet of Metoprolol for the sustained activity and prolongation of gastric residence time to improve the bioavailability of the drug. Metoprolol was chosen as a model drug because it is better absorbed in the stomach than the lower gastro intestinal tract.Methods: The experimental work was divided into pre-formulation studies, formulation development, and evaluation. Standardization of drug and excipients confirmed the authentication of the samples. Floating test were conducted for all formulations, In

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14

Shubham Tiwari, Satish Kumar Sarankar, Sushma Somkuwar, and Sushma Somkuwar. "Formulation and evaluation of ranitidine floating tablet." International Journal of Frontiers in Biology and Pharmacy Research 3, no. 1 (2022): 046–52. http://dx.doi.org/10.53294/ijfbpr.2022.3.1.0022.

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The aim of present investigation is to formulate floating tablet to increase duration of action of ranitidine. Floating tablet of ranitidine has long duration of action as compare to its sustained release formulation, Floating tablet has double duration of action than sustained release formulation. Floating tablet is developed by using various polymers like HPMC (15000) and few grades of carbopol, citric acid and sodium bicarbonate were added for effervescence. Tablets were prepared by wet granulation technique by using single operation punch machine in different formulation with polymers, als

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15

Goyal, Anil K., and Vinesh Kumar. "In-vitro Evaluation and Optimization of Sacubitril and Valsartan Floating Tablet using Natural Polymer." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1454–58. http://dx.doi.org/10.25258/ijddt.13.4.51.

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Oral systems have become gradually extensive for human consumption because of their numerous advantages, such as formulation efficiency, cost-effectiveness, and patient safety compliance. These systems offer a versatile platform for controlled drug release, allowing precise targeting of absorption site in the gastrointestinal tract. Accomplishing ideal therapeutic results for certain medications often requires precise control of drug release at specific locations within the gastrointestinal tract. In this study, our goal was to create a floating drug delivery system for two vital cardiovascula

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16

Jabeen, Arshiya. "Formulation and In Vitro Evaluation of Floating Effervescent Tablets of Levodropropizine." International Journal of Trend in Scientific Research and Development Volume-2, Issue-2 (2018): 1529–38. http://dx.doi.org/10.31142/ijtsrd10724.

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17

Pathak, Sudhakar, Harish Pandey, and Sunil Kumar Shah. "Formulation and Evaluation of Floating Matrix Tablets of Sacubitril and Valsartan." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 298–309. http://dx.doi.org/10.22270/jddt.v9i4-s.3322.

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Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The purpose of this research was to develop and

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18

Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,

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19

Varshi, Reena, Vikas Jain, Pradeep Pal, and Narendra Gehalot. "Formulation and Evaluation of Extended Release Gastroretentive Tablets of Metroprolol Succinate." Journal of Drug Delivery and Therapeutics 12, no. 5-S (2022): 127–32. http://dx.doi.org/10.22270/jddt.v12i5-s.5653.

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This study aimed to produce a gastroretentive floating tablet of Metoprolol succinate and examine the effects of release retardant on in vitro drug release. Metoprolol succinate is a β1 selective antagonist used as an Anti-hypertensive, Antiarrhythmic, and Anti Angina. Metoprolol succinate has 48% oral bioavailability due to limited absorption from the lower gastrointestinal tract. The Metoprolol succinate floating tablets were designed to increase stomach retention, prolong drug release, and enhance drug bioavailability. To shorten the floating lag time, hydrophilic polymers like Hydroxypropy

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20

Deshmukh, Aishwarya V., Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." Der Pharma Chemica 15, no. 6 (2023): 4. https://doi.org/10.5281/zenodo.13353444.

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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time

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Aishwarya, V. Deshmukh, Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." DER PHARMA CHEMICA 15, no. 6 (2023): 4. https://doi.org/10.4172/0975-413X.15.6.142-146.

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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time

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22

S, Revathi, Raj Kumar M, Kathirvel S, et al. "FORMULATION AND EVALUATION OF HYDRODYNAMICALLY BALANCED FLOATING TABLETS OF GLYCYRRHIZA GLABRA EXTRACT." International Research Journal Of Pharmacy 13, no. 2 (2022): 9–13. http://dx.doi.org/10.7897/2230-8407.1302181.

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The aim of the study is to formulate, optimize and evaluate Glycyrrhiza glabra floating tablets using 23 optimization technique for the treatment of asthma. The extract of Glycyrrhiza glabra was prepared by subjecting crude drug to hot continuous percolation method using Soxhlet apparatus using distilled water and ethanol. The floating matrix tablets of Glycyrrhiza glabra was prepared by wet granulation technique using extract of Glycyrrhiza glabra, HPMC K15M as polymer, starch/honey as binder and sodium bicarbonate & citric acid as effervescent agents by 23 factorial design. The independe

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Pawar, Harshal Ashok, Pooja Ramchandra Gharat, Rachana Vivek Dhavale, Pooja Rasiklal Joshi, and Pushpita Pankajkumar Rakshit. "Development and Evaluation of Gastroretentive Floating Tablets of an Antihypertensive Drug Using Hydrogenated Cottonseed Oil." ISRN Pharmaceutics 2013 (December 18, 2013): 1–9. http://dx.doi.org/10.1155/2013/137238.

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The aim of the present work was to develop a gastroretentive floating tablet of Atenolol and investigate the effects of both hydrophilic and hydrophobic retardant on in vitro release. Atenolol is an antihypertensive drug with an oral bioavailability of only 50% because of its poor absorption from lower gastrointestinal tract. The floating tablets of Atenolol were prepared to increase the gastric retention, to extend the drug release, and to improve the bioavailability of the drug. The floating tablets were formulated using hydrophilic polymers as Hydroxy propyl methyl cellulose (HPMC K4M and H

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Nilesh, Ghuge*1 Aditya Patil2 Sudesh Sanap2 Swati Zade2 Dr. Sanjay Toshniwal4 Dr. Vishal R. Rasve5. "Formulation and Evaluation of Bilayer Floating Tablets for Gastro-Retentive Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1795–809. https://doi.org/10.5281/zenodo.15383936.

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The objective of the present study was to formulate and evaluate bilayer floating tablets of Lisinopril to enhance its gastric residence time and provide sustained drug release, thereby improving its bioavailability and therapeutic efficacy. Nine formulations (FE1–FE9) were developed and subjected to comprehensive post-compression evaluations including thickness, hardness, friability, weight variation, and drug content uniformity. All formulations complied with pharmacopeial standards, exhibiting acceptable physical properties. In vitro floating studies demonstrated that all tablets had

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25

Rathi, J. C., V. Rathi, and S. Tamizharasi. "DEVELOPMENT AND IN VITRO EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF ACECLOFENAC." INDIAN DRUGS 53, no. 09 (2016): 63–66. http://dx.doi.org/10.53879/id.53.09.10548.

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The objective of the present investigation is to attain optimized floating drug delivery system for aceclofenac by determining the effects of some important factors for the prolongation of gastric residence time. Floating microspheres were prepared by solvent diffusion–evaporation method using ethyl cellulose and hydroxypropylmethylcellulose. A central composite design was applied to optimize the formulation. An appropriate balance between the levels of the polymer and stirring speed was imperative to acquire maximum drug entrapment efficiency, sustained release of the drug, floating ability a

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Abhishek, Bhosale*1 Priti Shinde2. "Formulation and Evaluation of Metformin HCL Gastroretentive Floating Sustained Released Tablet." International Journal of Scientific Research and Technology 2, no. 6 (2025): 06–16. https://doi.org/10.5281/zenodo.15566055.

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The Metformin HCl Gastroretentive Floating Sustained Release Tablet was formulated using the Wet Granulation method. This tablet incorporates an effervescent system, where Hydroxypropyl Methylcellulose (HPMC) K 100, a swellable polymer, facilitates the floating mechanism. Sodium bicarbonate is employed to create the effervescent system. A synergistic combination of HPMC K 100 and Xanthan Gum enhances the sustained release profile of the formulation. The prepared gastroretentive floating tablets were evaluated for various pharmaceutical parameters, including bulk density, tapped density, angle

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27

P, Poornima, Abbulu K, and Mukkanti K. "GASTRO-FLOATING TABLETS OF REPAGLINIDE: PREPARATION AND IN VIVO EVALUATION." Asian Journal of Pharmaceutical and Clinical Research 11, no. 7 (2018): 291. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.25776.

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Objective: Current research concerns the expansion of repaglinide matrix floating tablets, which are designed to prolong the gastric residence time, increase the drug bioavailability, and diminish the side effects.Methods: Different formulations of repaglinide floating tablets were prepared with different grades of hydroxypropyl methylcellulose (HPMC) and other agents. Evaluation parameters and in vivo bioavailability studies were conducted in the suitable model.Results: Among all the formulations, F21 containing HPMC K1500 PH PRM, Polyox WSR 303, and sodium bicarbonate, as gas generating agen

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S. Chandra, Amritha. J, and N. Senthil Kumar. "Formulation and evaluation of floating tablets containing for selected antibiotic." IJPAR JOURNAL 13, no. 4 (2024): 834–44. https://doi.org/10.61096/ijpar.v13.iss4.2024.834-844.

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Floating tablets were prepared using direct compression with varying ratios of Karaya gum, Carbopol, and Xanthan gum. The preformulation studies included drug description, solubility, pH, and compatibility testing through infrared spectroscopy. Post-compression evaluation parameters included weight variation, thickness, hardness, friability, drug content, tablet density, floating test, swelling index, and in vitro dissolution studies. Results indicated that the formulated tablets met all standard physicochemical parameters. Floating tests demonstrated that the tablets remained buoyant for over

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29

Sahu, Ragini, and Sarang Jain. "Development and Characterization of Floating Microspheres of Dexrabeprazole Sodium for the Treatment of Peptic Ulcer." Journal of Drug Delivery and Therapeutics 12, no. 5-S (2022): 20–26. http://dx.doi.org/10.22270/jddt.v12i5-s.5616.

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Dexrabeprazole sodium (DEX) is R (+)-isomer of rabeprazole. DEX has been used in the treatment of gastroesophageal reflux disease by suppressing gastric acid secretion. It acts as a proton pump inhibitor of the H+ /K+ ATPase enzyme. The purpose of this research was to prepare a floating drug delivery system of DEX. The floating microspheres can be prepared for the improvement of absorption and bioavailability of DEX by retaining the system in the stomach for prolonged period of time. Floating microspheres of DEX were prepared using different polymers like ethyl cellulose, hydroxy propyl methyl

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Semalty, A., and A. Semwal. "GASTRORETENTIVE FLOATING MICROSPHERE OF NATEGLINIDE: FORMULATION, EVALUATION AND EFFECT OF DRUG-POLYMER RATIO." INDIAN DRUGS 51, no. 06 (2014): 37–43. http://dx.doi.org/10.53879/id.51.06.10083.

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The study aims to develop gastroretentive floating drug delivery system of nateglinide which is used in the treatment of type – II diabetes. Due to the short biological half life of drug (about 1.5 hours), frequent dosing is required to maintain its therapeutic effect. Therefore, to prolong the gastric retention of nateglinide, its oil entrapped floating microspheres (different formulations with different drug to polymer ratio) were prepared using sodium alginate by emulsion gelation method. The prepared floating microspheres were subjected to evaluation for surface characteristic, entrapment

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Kapil, Jalodiya, Jain Sourabh, and Shukla Karunakar. "Formulation and evaluation of gastro-retentive floating tablets of terbinafine." GSC Biological and Pharmaceutical Sciences 13, no. 1 (2020): 257–66. https://doi.org/10.5281/zenodo.4264695.

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Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of terbinafine were prepared by direct compression method using altered conc

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Jafar, Mohammed, Mohammed Salahuddin, Mohd Sajjad Ahmad Khan, et al. "Preparation and In Vitro-In Vivo Evaluation of Luteolin Loaded Gastroretentive Microsponge for the Eradication of Helicobacter pylori Infections." Pharmaceutics 13, no. 12 (2021): 2094. http://dx.doi.org/10.3390/pharmaceutics13122094.

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The current study aimed to develop a luteolin gastric floating microsponge for targeting Helicobacter pylori. The microsponge formulations were prepared by a quasi-emulsion method, and then evaluated for various physicochemical variables. The best microsponge was further assessed for drug-polymer interactions, surface morphology, in vivo floating, and in vitro anti H. pylori activity. The formulation which exhibited comparatively good production yield (64.45% ± 0.83), high entrapment efficiency (67.33% ± 3.79), prolonged in vitro floating time (>8 h), and sustained in-vitro drug release was

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Yehualaw, Adane, Chernet Tafere, Zewdu Yilma, and Solomon Abrha. "Formulation and In Vitro Evaluation of Furosemide Floating Matrix Tablets Using Boswellia papyrifera Resin as Matrix Forming Polymer." BioMed Research International 2023 (October 26, 2023): 1–11. http://dx.doi.org/10.1155/2023/4322375.

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The stomach and upper part of the small intestine are where furosemide is primarily absorbed when treating edema brought on by congestive heart failure (CHF), hepatic cirrhosis, renal impairment, and nephrotic syndrome. This narrow absorption window is responsible for furosemide’s limited oral bioavailability. So creating a gastroretentive floating tablet could be beneficial. Natural polymers are advised for use in medication delivery because they are readily available in nature, biodegradable, relatively inexpensive, biocompatible, and nontoxic. Olibanum is a natural plant-based polymer obtai

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Basher, Taha A., and Entidhar J. Muhammad. "Formulation and In-vitro Evaluation of Itraconazole Floating Microparticles." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 1 (2020): 236–46. http://dx.doi.org/10.31351/vol29iss1pp236-246.

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Itraconazole (ITZ) is an antifungal drug (BCSII) used for the treatment of local and systemic fungal infections. Furthermore, ITZ used as an antifungal prophylaxis for immunocompromised patients. The objective of the study is to overcome the two problems of low and pH dependent solubility of ITZ by its preparation as floating microparticles. Firstly, pH-dependent floating microparticles were prepared using oil in water solvent evaporation method, from which the best one (F7) selected as a best pH-dependent formula with composition of ITZ (200mg),EC (800mg), HPMC 15cps (200mg) and s

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J, Meghana K., Ashok Kumar P, Suresh V. Kulkarni, and Manjunath K. "Formulation and In Vitro Evaluation of Floating Microspheres of Anti Diabetic Drug." International Journal of Pharma Research and Health Sciences 7, no. 3 (2019): 3007–12. http://dx.doi.org/10.21276/ijprhs.2019.03.10.

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Baratam, S. R., and V. R. Jayanthi. "PREPARATION AND EVALUATION OF FLOATING MATRIX SYSTEM OF LEVOFLOXACIN HEMIHYDRATE TABLETS." INDIAN DRUGS 55, no. 08 (2018): 67–70. http://dx.doi.org/10.53879/id.55.08.11181.

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Gastro floating drug delivery system (GFDDS) of Levofloxacin hemihydrate (LVF), category of Quinoline antibiotic used to treat Helicobacter pylori infection. The aim of the study was to develop a Floating matrix system (FDDS) of LVF for sustained release to improve the extended retention in stomach and local site specific action in the stomach. Preparation of LVF tablets using wet granulation method using HPMC K4M with Sodium bicarbonate as effervescent agent. All formulations were developed and evaluated for Floating properties for swelling characteristics and in vitro drug release studies. I

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Hasan, Ikramul, Tushar Saha, and Md Selim Reza. "Preparation and In-vitro Characterization of Gastroretentive Floating Tablets of Domperidone." Bangladesh Pharmaceutical Journal 22, no. 2 (2019): 170–75. http://dx.doi.org/10.3329/bpj.v22i2.42300.

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The present investigation was design for domperidone floating table preparation and in-vitro characterization. The ultimate target was increasing gastric retention by means of floatability of the tablet. Hydrophilic cellulosic polymers, Methocel K15M and Methocel K100M were used in this experiment for achieving release controlling property. Sodium bicarbonate played the key role of floatation by generating gas. Direct compression was the method of choice for preparing the tablets. The tablets were evaluated for physical parameters, buoyancy study, total floating time determination and dissolut

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Dr N Swathi, Dr N. Swathi, J. Madhuritha J. Madhuritha, K. Anusha K. Anusha, S. Kavya S. Kavya, Ch Leena Ch. Leena, and V. Poojitha V. Poojitha. "Formulation and in-vitro evaluation of Gastro retentive floating tablets of Cefixime Trihydrate by using Natural Polymers." International Journal of Pharmaceutical Science Invention 14, no. 3 (2025): 35–46. https://doi.org/10.35629/6718-14033546.

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The Floating drug delivery system is a novel approach in the Gastro retentive drug delivery systems (GRDDS). Floating system is needed for those drugs having a stomach or upper small intestine absorption window. This process does not affect on the rate of gastric emptying over an extended time as it a less dense method and therefore stay buoyant in the stomach and slowly release the drug. System floats on the gastric contents thereby releasing the drug slowly at a desired rate from the system which results in an increased gastric residence time (GRT) and a better control of the fluctuations in

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Semalty, Mona, Shikha Yadav, and Ajay Semalty. "Preparation and Characterization of Gastroretentive Floating Microspheres of Ofloxacin Hydrochloride." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 1 (2010): 819–23. http://dx.doi.org/10.37285/ijpsn.2010.3.1.4.

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As Ofloxacin is preferably absorbed from the upper part of the gastrointestinal tract and is readily soluble in the acidic environment of the stomach, the floating microspheres of ofloxacin were formulated to develop gastroretentive formulation. These floating microspheres release the drug in the stomach and upper gastrointestinal tract and thereby improve the bioavailability. In the present study, six formulations of ofloxacin hydrochloride were prepared as floating microspheres by solvent diffusion technique using polymers such as ethyl cellulose, polyvinyl pyrrolidone K-90 and poly vinyl al

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Patel, Keyur S., Akshar N. Rao, Deepa R. Patel, Dhaval M. Patel, and Advaita B. Patel. "Formulation and Evaluation of Gastroretentive Floating Tablets of Quetiapine Fumarate." Journal of Drug Delivery and Therapeutics 11, no. 3-S (2021): 65–73. http://dx.doi.org/10.22270/jddt.v11i3-s.4833.

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The objective of the present study was to develop gastroretentive floating tablets of quetiapine fumarate. The gastroretentive floating tablets of quetiapine fumarate were formulated using natrosol 250 HHX as a sustained release polymer and sodium bicarbonate as a gas forming agents. A 32 factorial design was employed to study the influence of concentration of natrosol HHX 250 (X1) and concentration of sodium bicarbonate (X2) on the dependent variables % drug release at 1h (Y1), % drug release at 8 h (Y2) and floating lag time (Y3). The optimized formulation (O1) showed floating lag time 49 ±

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Arshiya, Jabeen. "Formulation and In Vitro Evaluation of Floating Effervescent Tablets of Levodropropizine." International Journal of Trend in Scientific Research and Development 2, no. 2 (2018): 1529–38. https://doi.org/10.31142/ijtsrd10724.

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The present study is the development of Hydrodynamically Balanced Systems HBS of Levodropropizine, an antitussive agent, which are designed to increase the gastric residence time, thus prolonging the drug release. Levodropropizine HBS were prepared by using various viscosity grades of hydroxypropyl methylcellulose K4M, K15M, K100M by Direct compression technique. The prepared HBS tablets were evaluated for various physical characteristics and optimized formulation was identified. Formulation F3 prepared with HPMC K4M showed results by releasing 97.14 ±SD of drug in 24 h in a controlled

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Gore, Aarti* Gondkar Tejas Gorde Mahesh Mhaske Manjusha. "Formulation And Evaluation of Effervescent Based Gastro Retentive Floating Tablets of Nifedipine." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1458–72. https://doi.org/10.5281/zenodo.15379767.

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This study aims to develop and assess gastro-retentive floating tablets of nifedipine, designed to sustain drug release for up to 12 hour. The formulation utilize natural polymers, including xanthan gum and gum tragacanth employing a direct compression method. An effervescent gas generating agent, consisting of sodium bicarbonate, was incorporated to facilitate the floating capability of the tablets. The prepared gastroretentive floating tablets underwent a series of evaluation, including drug-excipient compatibility studies, weight variation, thickness, hardness, content uniformity, in vitro

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Vargas-Accarino, Elena, Carlos Herrera-Montávez, Santiago Ramón y Cajal, and Trond Aasen. "Spontaneous Cell Detachment and Reattachment in Cancer Cell Lines: An In Vitro Model of Metastasis and Malignancy." International Journal of Molecular Sciences 22, no. 9 (2021): 4929. http://dx.doi.org/10.3390/ijms22094929.

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There is an unmet need for simplified in vitro models of malignancy and metastasis that facilitate fast, affordable and scalable gene and compound analysis. “Adherent” cancer cell lines frequently release “free-floating” cells into suspension that are viable and can reattach. This, in a simplistic way, mimics the metastatic process. We compared the gene expression profiles of naturally co-existing populations of floating and adherent cells in SW620 (colon), C33a (cervix) and HeLa (cervix) cancer cells. We found that 1227, 1367 and 1333 genes were at least 2-fold differentially expressed in the

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Ruiz-Caro, Roberto, and María D. Veiga. "In vitro Evaluation of Acyclovir/Chitosan Floating Systems." Materials 3, no. 12 (2010): 5195–211. http://dx.doi.org/10.3390/ma3125195.

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Anepu, Sarada, Lohithasu Duppala, and Soma Sundari M. "FORMULATION DEVELOPMENT, CHARACTERIZATION AND IN- VITRO EVALUATION OF FLOATING MATRIX DOSAGE FORM OF TRAMADOL HYDROCHLORIDE USING VARIOUS POLYMERS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 281. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15587.

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Objective: The purpose of present study was to formulate the gastro retentive floating tablets of tramadol hydrochloride for enhancement of the gastric residence time.Methods: The floating tablets were prepared by direct compression method and evaluated for hardness, thickness, and friability of the tablets. The in vitro drug release studies were performed for different formulations and to optimize the best formulae based on the dissolution profiles.Results: Fourier transform infrared spectroscopy and differential scanning calorimetry studies revealed that there was no interaction between tram

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Vaishnav, Parul, Kuldeep Vinchurkar, and Dinesh K. Mishra. "DESIGN AND DEVELOPMENT OF GASTRO-RETENTIVE FLOATING TABLET CASE USING FDM 3D PRINTING TECHNOLOGY." INDIAN DRUGS 61, no. 08 (2024): 44–53. http://dx.doi.org/10.53879/id.61.08.14554.

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The aim of this research was to examine a novel Fused Deposition Model (FDM) 3D Printing Method for creating a gastro-retentive floating tablet case containing metronidazole compressed tablet. Metronidazole was employed as a model drug and successfully integrated into floating tablet case composed of polyvinyl alcohol filament. The tablet design was made by AutoCAD software and the slicing of tablet design was carried out. To evaluate the formulation parameters for 3D printed tablet case, various orifice sizes were optimized. These 3D printed tablet cases were assessed for weight variation, fr

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Pashikanti, Shailaja, and Jyothsna B. "FORMULATION AND EVALUATION OF FLOATING IN SITU GEL OF CIPROFLOXACIN." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 198. http://dx.doi.org/10.22159/ijap.2019v11i1.28603.

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Objective: The objective of the study was to develop floating in situ gel formulations of Ciprofloxacin that has a narrow absorption window and mainly absorbed in the proximal areas of GIT. These formulations increases the targeted action on bacteria for a longer time that can be used in the treatment of Helicobacter pylori (H. pylori) infections and urinary tract infections.Methods: In situ gel formulations were prepared by varying concentrations of sodium alginate as in situ gel forming bio-degradable polymer and calcium carbonate as a cross-linking agent. The formulations were evaluated for

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Durgapal, Sumit, Sayantan Mukhopadhyay, and Laxmi Goswami. "PREPARATION, CHARACTERIZATION AND EVALUATION OF FLOATING MICROPARTICLES OF CIPROFLOXACIN." International Journal of Applied Pharmaceutics 9, no. 1 (2016): 1. http://dx.doi.org/10.22159/ijap.2017v9i1.14183.

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Objective: The main purpose of this study is to prepare a floating micro articulated drug delivery system of ciprofloxacin by using non-aqueous solvent evaporation technique to increase the bioavailability and therapeutic effectiveness of the drug by prolonging its gastric residence time.Methods: Floating microparticles were prepared by using different low-density polymers such as ethyl cellulose and hydroxypropyl methylcellulose either alone or in combination with the aid of non-aqueous solvent evaporation technique. All the formulated microparticles were subjected to various evaluation param

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Rohit Jaimini and Dr. Manish Jaimini. "FORMULATION AND OPTIMIZATION OF GASTRO-RETENTIVE FLOATING TABLETS OF ENALAPRIL MALEATE AND LOSARTAN FOR ENHANCED BIOAVAILABILITY AND THERAPEUTIC EFFICACY." Tropical Journal of Pharmaceutical and Life Sciences 12, no. 1 (2025): 01–10. https://doi.org/10.61280/tjpls.v12i1.170.

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The objective of this study was to formulate and optimize gastro-retentive floating tablets of Enalapril Maleate and Losartan to enhance their bioavailability and therapeutic efficacy. These drugs, commonly used in the management of hypertension and heart failure, suffer from limited solubility and rapid gastric emptying, which reduce their effectiveness. Gastro-retentive floating tablets were developed using hydroxypropyl methylcellulose (HPMC K4M) and guar gum as release-controlling agents, with sodium bicarbonate and citric acid as effervescent agents to ensure buoyancy. Twenty formulations

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Hasan, Md Asif, Sabiha Sultana, Sabiha Sultana, Md Masud Kaisar Bhuiyan, Md Selim Reza, and Mohammad Salim Hossain. "Formulation and In vitro Characterization of Hydrochlorothiazide Gastroretentive Floating Drug Delivery System." Dhaka University Journal of Pharmaceutical Sciences 14, no. 2 (2016): 163–70. http://dx.doi.org/10.3329/dujps.v14i2.28506.

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The purpose of the study was to develop and optimize floating bioadhesive gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach, using hydrochlorothiazide (HCTZ) as a model drug. Formulated matrix tablets were prepared by direct compression method with two different rate controlling polymer HPMC K4M and Carbopol 971. The formulated tablets were evaluated for physical characterization, floating lag time, swelling index and drug content uniformity. The drug release study was carried out in 0.1N HCl as the me

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