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Dissertations / Theses on the topic 'In vitro gut model'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Coussa-Charley, Michael. "A novel «in vitro» mucosal gut bacterial adhesion model." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106420.

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The gut bacterial system is truly a dynamic, complex organ. Although there is a constant flux of activity, the microflora can be considered as a bioreactor at a quasi-steady state throughout a person's life. In fact, the relative composition of different bacterial genera can lead directly to health or disease. By understanding how the gut is colonized and what can be administered to alter overall composition, one would be able to use the gut as a legitimate target for drug delivery. In vitro gut adhesion models have been developed exactly for this purpose however have several limitations. In t

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2

GARUGLIERI, ELISA. "EFFECTS OF SILVER NANOPARTICLES ON IN VITRO GUT MICROBIAL MODELS AND OTHER ANAEROBIC ENVIRONMENTS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/488359.

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The impacts of AgNPs on both natural and engineered ecosystems is a topic of outstanding importance having socio-economic consequences on medical, industrial and environmental fields. Silver nanoparticles are widely used as antimicrobial agents in consumer products for domestic, environmental, medical, and industrial applications. Release of AgNPs from nanoenabled products has been observed, and the potential impacts of such releases on a wide variety of organisms at many trophic levels have been recognized. However, there has been little exploration of the impact of AgNPs on the microflora as

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3

Gérémie, Lauriane. "Development of an in-vitro intestinal model featuring peristaltic motion." Thesis, Sorbonne université, 2019. http://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS118.pdf.

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Le Gut-on-chip fait partie d'un thème de recherche plus générale, appelez Organ-on-chip qui a pour objectif de développer des modèles in-vitro qui récapitulent des caractéristiques essentielles de l'organe d'intérêt. Dans le cas de l'intestin, les Gut-on-chip plateformes ont été principalement développés pour reconstituer soit l'architecture 3D de l'intestin, soit sa dynamique et plus particulièrement le péristaltisme. Durant ma thèse j'ai développé une nouvelle et polyvalente Gut-on-chip, présentant ces deux aspects du micro-environnement intestinale. Cette Peristalsis-on-chip nous a permis d

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Crowther, Grace. "Development and characterisation of an in vitro human gut model to study the biofilm mode of growth of Clostridium difficile and the indigenous gut microbiota." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5736/.

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Clostridium difficile infection (CDI) is associated with significant patient morbidity, mortality and financial burden. Until recently, antimicrobial treatment options were limited to metronidazole and vancomycin, but both agents are associated with recurrence rates of approximately 20%. The human gastrointestinal tract harbours a complex microbial community which exist in planktonic and sessile form. Sessile organisms are known to cause chronic infection such as cystic fibrosis. Mucosal biofilms exist on surfaces of the gastrointestinal tract, but the existence and role of C. difficile in the

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5

VERDILE, NICOLE. "MORPHOLOGICAL AND FUNCTIONAL CHARACTERIZATION OF THE RAINBOW TROUT GUT (ONCORHYNCHUS MYKISS) TO DEVELOP A PREDICTIVE IN VITRO INTESTINAL MODEL." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/928771.

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To obtain an adequate comprehension of the intestinal morphology and function, I performed a detailed morphological evaluation of the intestinal epithelial cells lining the rainbow trout gut. This was obtained through histological, histochemical and immunohistochemical observation, accurate stereological analysis, morphometric measurements, and fine qualitative and quantitative characterization of goblet cells secreting activity at typical time points of in vivo feeding trials (50, 150 and 500 g). The gross anatomy of the rainbow trout gut corresponds to the general description of the organ in

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Tuohy, K. "Measurement of DNA transfer in the gut using in vitro and in vivo models." Thesis, University of Surrey, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322465.

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7

Shah, Pranjul, Joëlle V. Fritz, Enrico Glaab, et al. "A microfluidics-based in vitro model of the gastrointestinal human–microbe interface." NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/614760.

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Changes in the human gastrointestinal microbiome are associated with several diseases. To infer causality, experiments in representative models are essential, but widely used animal models exhibit limitations. Here we present a modular, microfluidics-based model (HuMiX, human-microbial crosstalk), which allows co-culture of human and microbial cells under conditions representative of the gastrointestinal human-microbe interface. We demonstrate the ability of HuMiX to recapitulate in vivo transcriptional, metabolic and immunological responses in human intestinal epithelial cells following their

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8

Vangala, Swathi. "Human Cytochrome P450 3A4 Over-Expressing IEC-18 and MDCK Cell Lines as an In-Vitro Model to Assess Gut Permeability and the Enzyme Metabolism." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/273.

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Purpose. The fate of an orally administered drug is dependent on many parameters before it can reach the systemic circulation, including drug absorption and first-pass metabolism in the gut and the liver. Mammalian cells lines such as MDCK and Caco-2 are commonly employed to assess drug permeability but they lack or have low expression level of drug metabolism enzyme expression such as CYP3A4, which contributes to significant first-pass gut and liver metabolism for many drugs. Consequently, these cell lines are not sufficient to integrate metabolism when assessing drug absorption. Here, we tes

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Deschamps, Charlotte. "Impact du poids corporel et d'une perturbation antibiotique sur le microbiote intestinal du chien : simulation in vitro et stratégies de restauration." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2023. http://www.theses.fr/2023UCFA0055.

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Différentes tailles de chiens sont associées à des variations de la physiologie digestive, principalement liées au colon et à ses microorganismes résidents. Ce microbiote intestinal joue un rôle clé en santé, soutenant les processus nutritionnels, immunologiques et physiologiques. Néanmoins, les maladies ou l'antibiothérapie peuvent altérer l'équilibre microbien et induire un état perturbé appelé dysbiose. Pour restaurer l'eubiose du microbiote, de nouvelles stratégies de restauration ont été développées telles que les pré, pro ou postbiotiques. Cependant, peu d'études ont évalué leurs effets

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10

MANCINO, ROBERTA. "Influence of cow diet on nutritional profile of milk and dairy products and effects on alterations of human gut microbiota by an in vitro digestion model." Doctoral thesis, Università di Foggia, 2018. http://hdl.handle.net/11369/363264.

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I consumatori richiedono costantemente la presenza sul mercato di alimenti salutistici, che in termini di latte e prodotti lattiero-caseari si traducono in un latte con percentuali più elevate di acidi grassi “sani” come gli acidi grassi polinsaturi (PUFA), ed una più bassa percentuale di acidi grassi saturi (SFA). Il latte e prodotti lattiero-caseari contribuiscono in modo significativo all’assorbimento di sostanze nutritive essenziali nella dieta. Nonostante ciò, il consumo di latte ha fatto registrare un’inflessione a causa delle linee guida nutrizionali che suggeriscono di limitare il cons

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Cordonnier, Charlotte. "Survie et pathogénicité des EHEC dans l'environnement digestif : Interactions avec le microbiote et l'épithélium intestinal. : Influence de l'administration de levures probiotiques." Thesis, Clermont-Ferrand 1, 2015. http://www.theses.fr/2015CLF1MM21/document.

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Les Escherichia coli entérohémorragiques (EHEC) sont des pathogènes majeurs pour l’homme responsables de toxi-infections alimentaires pouvant évoluer vers des complications potentiellement mortelles. La pathogénicité de ces souches est essentiellement due à la production de Shiga-toxines (Stx), même si d’autres facteurs semblent jouer un rôle important dans la virulence, comme des facteurs d’adhésion. La survie et la régulation des facteurs de virulence des EHEC dans l’environnement digestif humain sont des facteurs clés dans la pathogénicité bactérienne, mais restent à ce jour mal décrits, es

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Müller, Jakob Verfasser], Heinrich H. D. [Akademischer Betreuer] [Meyer, Michael W. [Akademischer Betreuer] Pfaffl, and Andrea K. [Akademischer Betreuer] Büttner. "Secondary plant metabolites and gut health: functional studies on porcine small intestine in vitro models / Jakob Müller. Gutachter: Michael W. Pfaffl ; Andrea K. Büttner. Betreuer: Heinrich H. D. Meyer." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1030099545/34.

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13

Li, Yingchuan. "A SUSY SO(10) GUT model with lopsided structure." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/6703.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Physics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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14

Kuwahara, M., T. Ogaeri, R. Matsuura, et al. "In vitro organogenesis of gut-like structures from mouse embryonic stem cells." Blackwell, 2004. http://hdl.handle.net/2237/7446.

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15

Jaiyeola, Etana Joy. "Gut microbiota in human type 2 diabetes : in-vivo and in-vitro studies." Thesis, University of Surrey, 2017. http://epubs.surrey.ac.uk/844975/.

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The gut microbiota plays an important role in the development of type 2 diabetes (T2D), which is an alteration in the diversity and abundance of the gut microbiota, favouring the growth of Gram-negative bacteria. Although a lot of studies have shown this to be the case, most of this work has been done in animal models with few studies in humans. In animal models of T2D, it is known that a high-fat diet alters the gut microbiota in favour of the growth of Gram–negative bacteria. The outer membrane of Gram-negative bacteria contains lipopolysaccharide (LPS) which is an endotoxin that can trigger

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16

Agans, Richard Thomas. "Modeling Effects of Diet on Human Gut Microbiota." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1472128769.

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Jiang, Lei. "On human gut microbial ecosystem : in vitro experiment, in vivo study and mathematical modelling." Thesis, Swansea University, 2013. https://cronfa.swan.ac.uk/Record/cronfa42214.

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The human gut microbiota is considered to be a highly specialized organ providing nourishment, regulating epithelial cell development, modulating innate immune responses and colonization resistances, and it significantly impacts human health and disease. Dispite of being extensively studied for several decades, the functionality of the microbiota colonization in the human gastrointestinal tract and the mechanisms of the interactions between the host and bacteria are still poorly understood. This research follows a novel and unique approach, which combines the complementary strengths of in vitr

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18

Nistor, Nicolae, and Monika Schustek. "Wie gut sind die guten alten FAQs?" Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-76312.

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Die zunehmende Nutzung der digitalen Medien im Rahmen des universitären Bildungsmanagements ist mit neuen Arbeitsweisen verknüpft. Dafür brauchen Hochschulmitarbeiter, Doktoranden und Studierende vielfältige Kompetenzen, die technisches Wissen und Können einschließen und im formellen Rahmen nicht vollständig abgedeckt werden können. Als Alternative zur Unterstützung durch spezialisierte Einrichtungen (wie z.B. IT-Helpdesks) bietet sich die gemeinsame Wissenskonstruktion und -kommunikation in der akademischen Wissensgemeinschaft an. Dabei stellt sich allerdings die Frage, inwieweit und unter we

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Hand, K. V. "Studies investigating in vitro nutrient stimulated secretion of gut satiety signals and potential mechanisms of release." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546355.

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FIORE, WALTER. "OVERALL ASSESSMENT OF A MODEL PROBIOTIC BACTERIUM: FROM GUT COLONIZATION TO CLINICAL EFFICACY." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/737193.

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Probiotics are “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. This definition is inclusive of a broad range of microbes and applications, whilst capturing the essence of probiotics (microbial, viable and beneficial to health). Specific guidelines describe the minimal requirement for the probiotic status. In particolar, the conventional process of selecting novel potential probiotic strains includes the assessment of: 1) the ability of the strains to survive during the gastrointestinal transit and reach alive the intestine, 2) the actual

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21

Joesten, William C. "Exploring the relationships between gut bacteria, gut permeability, and bacterial metabolism in the Non Obese Diabetic (NOD) mouse model of Type 1 Diabetes (T1D)." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1574423689823958.

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22

Wang, Xuedan. "Effect of inulin type fructans on protein fermentation by gut bacteria : in vitro and in vivo studies." Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/79980/.

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In Europe and Northern America, protein intake is high, whilst fibre intake is relatively low. With large amounts of protein entering the colon, bacterial proteolysis may have some negative effects through potentially toxic end-products. Prebiotics could have the potential to reverse negative consequences of gut bacterial protein fermentation. Single stage, pH controlled, anaerobic, stirred batch culture systems simulating the distal colon were applied first with faecal inoculum from both omnivore and vegetarian volunteers. Fermentation of different protein sources with and without supplementa

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Poh, Zijie. "Model Building in the LHC Era: Vector-like Leptons and SUSY GUTs." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1502809360161742.

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24

Kelsall, Ashlie Peta. "Studies on optimising the everted gut sac model (EGSM) in rat and possum tissue to compare selective drug movement across the intestinal wall." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14578.

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The in-vitro everted gut sac model has been used extensively in the laboratory environment to investigate the transfer of orally administered drugs across the intestinal wall of rodents. This model involves excision of fresh tissue from the small intestine, which is then everted and sectioned into individual sacs and incubated under mammalian physiological conditions in medium containing the target drug. One of the limitations of this model is the need to access tissue immediately following euthanasia, greatly restricting applicability for many species. This study investigated the movement of

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Chohan, M. B. N. "The impact of digestion and gut bioavailability, in vitro, on the polyphenolic associated activity of cooked culinary herbs." Thesis, Kingston University, 2011. http://eprints.kingston.ac.uk/22530/.

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Culinary herbs, the use of which has increased significantly in the last decade, are known to possess health promoting properties, which are attributed mainly to their polyphenols. However, despite the fact that such herbs undergo some form of cooking prior to consumption, there is a paucity of data concerning the effects of cooking on their properties. Furthermore, little is known of the disposition of these polyphenols following digestion and absorption, and thus it is not known whether these herbs have the potential to be significant contributors of dietary polyphenols at amounts used domes

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Holt, Marie Kragelund Bachmann. "In vitro and in vivo properties of GLP-1 producing neurons : the brain actions of a gut hormone." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10039312/.

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Glucagon-like peptide-1 (GLP-1) is an incretin and neuropeptide primarily known for its role in glucose homeostasis. GLP-1 also has potent anti-obesogenic potential, and is known to inhibit food intake, food reward, and diet-induced obesity. In addition, brain GLP-1 increases heart rate and mediates effects of acute stress. Within the brain, GLP-1 is produced by preproglucagon (PPG) neurons in the caudal brainstem. Although the potential role of GLP-1 has been studied through pharmacological activation of brain GLP-1 receptors, little is known about the cellular properties and physiological ro

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Chase, Teena D. "An in vitro model of reactive astrogliosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ49329.pdf.

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Worrall, Lisa Kirsty. "A 3D in vitro breast cancer model." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436812.

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Mistry, Rupal. "Host-gut microbiota interaction in health and disease using Drosophila melanogaster as a model organism." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:c5add9af-9abf-4664-8c62-4b462c35e2c2.

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The resident gut bacteria of the gastrointestinal tract (gut microbiota) have been known to influence the immune system. Yet the role of the immune system in shaping the gut microbiota composition across an organism's lifespan remains unclear. Previous work in mice has been conflicting and thus remains inconclusive. Here, Drosophila melanogaster was used as a model organism with a simpler gut commensal community to address this issue. Using four strains of Drosophila reflecting different immune statuses, we found that wild type and immune-compromised strains had the same Acetobacteraceae-domin

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Fois, Chiara Anna Maria. "A Gut-on-a-chip Model for Testing the Anti-inflammatory Effects of Active Compounds." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25967.

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Animal models are gold standards for testing active compounds on intestinal inflammatory conditions. However, the high costs involved cannot justify their use in all circumstances, such as in food and nutrition research. This study aimed to develop a gut-on-a-chip in vitro platform for screening the effect of anti-inflammatory compounds on gut inflammation. Because of its micrometre size, the chip allowed for reduced consumption of reagents. Furthermore, the use of constant media perfusion recreates the biological cues naturally present in the human body. CFD simulations were first performed t

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Eisa, Osama Eltayeb Idris. "Modulators of innate gut immunity to enteric viral infections : murine norovirus (MNV) as a model." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/271239.

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Challenged by a huge and diverse antigenic stimulus, the intestinal mucosa has developed a unique immune system that mainly functions to maintain tolerance to innocuous antigens while retaining the ability to respond swiftly to pathogenic threats. Central to this specialised immune system are the Intraepithelial Lymphocytes (IELs). These cells are uniquely located between Intestinal Epithelial Cells (IECs) ready to respond to exogenous antigens in the intestinal lumen. The intestinal immune system is constantly influenced, not only by the commensal microbiota, but also by the nutritional statu

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Djamiatun, Kis. "In vitro studies on induction of lymphocyte and cytokine responses to the gut protozoans Giardia lamblia and Giardia muris." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23882.

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In mice infected with 10$ sp4$ Giardia muris cysts, a peak lymphocyte proliferation in the spleen and Peyer's patches in response to Giardia extract occurred during the elimination and latent phases, respectively. This shows that the Peyer's patch cells are more responsive than the spleen to Giardia infection. Th2-type cytokines produced by Peyer's patch cells may play a protective role during the latent and acute phases. Th1-type cytokines may contribute to this production during the elimination phase. Cytokine production in response to Giardia extract in vitro was observed in mice immunized

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Saxton, Katie. "Development and mechanisms of fluoroquinolene resitance in epidemic clostridium difficile strians in a human gut model." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511177.

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Goggans, Mallory. "Elucidating Tomato Steroidal Glycoalkaloid Metabolism and Effects of Consumption onthe Gut Microbiome in a Pig Model." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1594824484770731.

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Rich, Barbara Sharon. "Development of an in vitro model for accommodation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28982.pdf.

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Aldsworth, Timothy Grant. "Microbial in vitro model of root surface caries." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360285.

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Ohene-Abuakwa, Yaw. "In vitro erythroid model for diamond blackfan anaemia." Thesis, St George's, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420364.

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Owen, Robert. "Tissue engineering an in vitro model of osteoporosis." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19265/.

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Postmenopausal osteoporosis is a skeletal disorder characterised by bone loss. Declining oestrogen levels postmenopause disrupt bone remodelling by over-stimulating resorption. Although the disorder is currently studied in animals, we should aim to minimise their use. Therefore, this thesis explored the feasibility of developing an in vitro model of postmenopausal osteoporosis using tissue engineering principles. The response of three osteoblast cell lines, MC3T3-E1, MLOA5, and IDG-SW3, to oestrogen was explored, finding only MC3T3-E1 was stimulated by the hormone. The ability of RAW264.7 to u

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Davern, Jordan W. "Development of a bioengineered microvascular in vitro model." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/201653/1/Jordan_Davern_Thesis.pdf.

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This thesis focuses on the development of methods to create stable microvascular structures using miniaturised devices containing microchannels and water-swollen networks known as hydrogels. The combination of miniaturised devices and hydrogels provide a platform to recreate key aspects of human tissues and organs in a laboratory setting. It examines different hydrogel materials and their capacity to facilitate microvascular network formation. It also introduces a novel concept termed "on-demand matrix reinforcement" to stabilise vascular structures in generating long term microvascular studie

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Rebelo, Sandra da Silva. "Desenvolvimento de um modelo in vitro para avaliação de um biogel antimicrobiano com potencial para o controlo da doença periodontal canina." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/20210.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A doença periodontal (DP) é uma das doenças mais frequentes na espécie canina, afetando cerca de 80-85% destes animais. Esta doença, de etiologia multifatorial, inicia-se com o desenvolvimento, na superfície do dente, de placa bacteriana, um biofilme composto maioritariamente por bactérias contidas numa matriz de polissacáridos extracelulares, com o potencial de inibir a ação antimicrobiana e as defesas naturais do hospedeiro. Os processos de agregação bacteriana constituem um fenómeno bastante importante na formação de biofilme ao c

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Farran, B. "Developing a recombinant model of the P2Y1 and P2Y11 receptor interactions mediating relaxation in gut smooth muscle." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464076/.

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ATP and ADP mediate gut smooth muscle relaxation through two receptors, P2Y1 and P2Y11. This project aims to investigate the interaction between these two receptors by developing a recombinant model of the P2Y receptors expressed in gut smooth muscle cells (SMCs) by transfecting the human P2Y11 receptor cDNA into CHO-K1 cells, which express an endogenous P2Y1 receptor. Individual clonal cell lines expressing different densities of hP2Y11 were isolated from this stably-transfected CHO-K1:P2Y11 pool and characterized. A clone expressing a “high” density of hP2Y11 (13) and a clone expressing a “l

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Hoffman, Jared D. "THE PREBIOTIC INULIN BENEFICIALLY MODULATES THE GUT-BRAIN AXIS BY ENHANCING METABOLISM IN AN APOE4 MOUSE MODEL." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacol_etds/24.

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Alzheimer’s disease (AD) is the most common form of dementia and a growing disease burden that has seen pharmacological interventions primarily fail. Instead, it has been suggested that preventative measures such as a healthy diet may be the best way in preventing AD. Prebiotics are one such potential measure and are fermented into metabolites by the gut microbiota and acting as gut-brain axis components, beneficially impact the brain. However, the impact of prebiotics in AD prevention is unknown. Here we show that the prebiotic inulin increased multiple gut-brain axis components such as scyll

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Mangwana, Noluxabiso. "The in vitro faecal evaluation of prebiotic effects of rooibos phenolic compounds on the gut microbiota of vervet monkeys (Chlorocebus pygerythrus)." Thesis, Cape Peninsula University of Technology, 2020. http://hdl.handle.net/20.500.11838/3109.

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Thesis (Master of Environmental Health)--Cape Peninsula University of Technology, 2020<br>Background: The development of metabolic disease is accompanied by changes in gut microbiota phenotype, including a decrease of beneficial bacteria and increase of pernicious bacteria of the gastrointestinal tract. A Western (high-fat and high-sugar) diet, sedentary lifestyle and altered gut microbiota diversity have been associated with an increased risk of developing metabolic diseases such as type 2 diabetes and its associated risk factor, obesity. Many researchers have studied the link between the g

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Ogue, Bon Eva. "In vitro investigations of the effects of dietary fibres and prebiotics on probiotic growth, antimicrobial activity and the canine gut microbiota." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511667.

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TRETOLA, MARCO. "FORMER FOODSTUFFS PRODUCTS INTENDED FOR PIG NUTRITION: IN VITRO AND IN VIVO NUTRITIONAL EVALUATION, IMPACT ON GROWTH PERFORMANCES AND GUT HEALTH." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/609808.

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La produzione animale riveste un ruolo chiave nel garantire la sicurezza alimentare. Tale ruolo viene esercitato soprattutto grazie all’approvvigionamento di prodotti di origine animale e prodotti dell’agricoltura. Tuttavia, a causa delle diminuite disponibilità di terreni destinati all’allevamento ed alla agricoltura, insieme ai cambiamenti climatici e alla riduzione delle risorse idriche, diventa sempre più importante aumentare la sostenibilità e l’efficienza del settore agroalimentare. Per fare ciò, diventa necessario soddisfare le crescenti esigenze utilizzando al tempo stesso una quantità

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Patient, J. D. "Development of an in-vitro epithelial-myofibroblast intestinal model." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33617/.

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In vitro studies of drug permeability are traditionally carried out using cultured monolayers of epithelial cell lines grown on semi permeable membranes. Caco-2 cells, which are colon-derived, spontaneously form polarised cell layers when cultured in vitro which are akin to an epithelium of enterocyte-like cells. The Caco-2 model has been developed as a powerful in vitro tool in the early assessment of human drug permeability and is even approved by regulatory agencies for biowaver applications (i.e. in vitro tests in lieu of in vivo animal experiments). As Caco-2 cells are derived from colon

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Hung, Chao-Chun. "In Vitro Model Systems of a-Synuclein Over-Expression." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485237.

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Parkinson's disease (PD) is the second most common neurodegenerative disease in humans. Pathologically, it is characterised by an accumulation of proteinaceous intraneuronal inclusions termed Lewy bodies (LBs). a-Synuclein is the major protein found at the core of LBs. However, it is not known what stimulus causes inclusion formation, or whether LBs are cytotoxic. I wished to address these questions using cell-based model systems. Consequently, stable transfected nonneuronal (HEK293) and neuronal (SH-SY5Y) cell lines were generated and cells could be induced to express wild type or mutants of

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Turner, Andrew. "Vitamin D metabolism in an In Vitro mineralisation model /." Title page and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09SB/09sbt9438.pdf.

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Sung, Hsing-Wen. "In vitro velocity measurements in a pulmonary artery model." Diss., Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/13388.

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Tretiak, Tania. "A bovine in vitro model of human cerebral vasospasm." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22819.

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Cerebral vasospasm is a common cause of ischemia and death in patients suffering from cerebral hemorrhage, most notably subarachnoid hemorrhage (SAH), and it usually occurs 4-14 days after the initial episode of bleeding. Many mediators of cerebral vasospasm (CVS) have been proposed, but at this time the pathogenesis of CVS is poorly understood, and oxyhemoglobin is thought to be the principal pathogenic agent.<br>This project was designed to examine the effects of oxyhemoglobin on the vascular tone of the middle and basilar cerebral arteries in vitro and to evaluate the validity of using bovi

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