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Dissertations / Theses on the topic 'In vitro hepatic systems'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Skipworth, J. R. A. "Hepatic mitochondrial renin-angiotensin systems." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1462711/.

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Introduction: The circulating renin-angiotensin system (RAS) was originally described as a key endocrine regulator of intravascular homeostasis; however, the existence of a local (tissue) RAS has become increasingly reported in a variety of tissues including liver. RAS components have now also been detected in rat heart, brain and smooth muscle cell mitochondria as well as within intramitochondrial dense bodies of rat adrenal tissue. Further, reduced RAS levels have been associated with improved endurance performance and fatigue resistance in human skeletal muscle, suggesting that low RAS acti

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2

Diaz, Gonzalo J. "Hepatic in vitro metabolism of 3-methylindole in pigs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ55622.pdf.

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Allen, Jared W. "Modulation of hepatic tissue function by oxygen in vitro /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3129953.

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4

Soltis, Anthony Robert. "Systems biology of diet-induced hepatic insulin resistance." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111272.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 192-205).<br>Human obesity is a world-wide health crisis that promotes insulin resistance and type 2 diabetes. Obesity increases intracellular free fatty acid concentrations in peripheral tissues, particularly the liver, which disrupts molecular

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5

Goli, Vidya M. Walker Glenn M. "Investigation of microfluidic hepatocyte and hepatic progenitor cell cultures in vitro." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1345.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Biomedical Engineering." Discipline: Biomedical Engineering; Department/School: Medicine.

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6

DUIGNAN, DAVID BERNARD. "IN VITRO METABOLISM OF POLYCHLORINATED BIPHENYLS BY DOG HEPATIC CYTOCHROMES P-450." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184156.

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The biochemical basis for the unique ability of Beagle dog liver microsomes to metabolize 2,2',4,4',5,5'-hexachlorobiphenyl (245-HCB) was investigated. The major phenobarbital (PB)-inducible cytochrome P-450 isozyme, called PBD-2, was purified to 95% homogeneity from liver microsomes of both control and PB-treated dogs, as evidenced by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In a reconstituted system containing cytochrome b₅, PBD-2 metabolized 245-HCB at a rate greater than three-fold that seen in liver microsomes from PB-treated dogs. Immunoblot analysis revealed that, upon

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7

Cubitt, Helen E. "In Vitro of Hepatic and Intestinal Conjugation Reactions and Impact on Drug Clearance Prediction." Thesis, Royal College of Art, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503043.

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8

Wood, Francesca. "Optimisation of in vitro methodology for drug metabolism studies to improve prediction of hepatic drug clearance." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/optimisation-of-in-vitro-methodology-for-drug-metabolism-studies-to-improve-prediction-of-hepatic-drug-clearance(0786531a-2e10-48a7-9b35-e2e7e1935338).html.

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As a critical parameter in pharmacokinetics, prediction of clearance is an integral aspect of drug discovery programmes. Since the liver is the major site of xenobiotic biotransformation, accurate prediction of hepatic clearance (CLh) is vital. The use of cellular and subcellular in vitro systems for this purpose is common practice; however, prediction accuracy tends to be poor. The aim of this thesis was to explore potential contributing factors to the underprediction of in vivo clearance, specifically with relation to the in vitro methodology of hepatocyte clearance assays, which is largely

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9

Hariparsad, Niresh. "Hepatic and Extra-Hepatic Induction of Drug Metabolizing Enzymes and Drug Transporters by Antiretrovirals, in the Presence and Absence of Viral Infection." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1153244440.

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10

Abass, K. M. (Khaled M. ). "Metabolism and interactions of pesticides in human and animal in vitro hepatic models." Doctoral thesis, University of Oulu, 2010. http://urn.fi/urn:isbn:9789514262999.

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Abstract Risk assessment of chemicals needs reliable scientific information and one source of information is the characterization of the metabolic fate and toxicokinetics of a chemical. Metabolism is often the most important factor contributing to toxicokinetics. Cytochrome P450 (CYP) enzymes are a superfamily of microsomal proteins playing a pivotal role in xenobiotic metabolism. In the present study, pesticides were used as representative xenobiotics since exposure to pesticides is a global challenge to risk assessment. Human and animal in vitro hepatic models were applied with the advanta

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11

Hobbs, Michael. "The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro." Thesis, University of Strathclyde, 2016. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27533.

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Rosuvastatin has poor passive membrane permeability and its uptake into the liver is mediated predominately by the transporter, Organic Anion Transporting Polypeptide 1B1 (OATP1B1). Cyclosporin A (CsA) is a potent inhibitor of a range of transporters, including OATP1B1 and clinical drug-drug interactions (DDI) have been reported with rosuvastatin. The aim of this study was to determine the uptake kinetics of rosuvastatin in human hepatocytes using a mechanistic model and to determine the inhibitory effect of CsA upon those kinetics. These data may then allow the extrapolation of in vitro to in

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12

Boulais, Lilandra. "Cryogel-integrated hepatic cell culture microchips for liver tissue engineering." Thesis, Compiègne, 2020. http://www.theses.fr/2020COMP2561.

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L’un des enjeux de l’industrie pharmaceutique aujourd’hui est de développer des modèles de foie in vitro fidèles pour améliorer la prédictivité des études précliniques, notamment l’étude de la toxicité et de l’efficacité des médicaments candidats. Ces dernières années, l’ingénierie tissulaire, approche multidisciplinaire pour développer des tissus, a mené au développement de nouvelles méthodes de culture cellulaire. Parmi elles, les cultures de cellules en 3D ou en perfusion ont permis d’obtenir des activités hépatiques similaires à celles observées in vivo. L’objectif de cette thèse est de co

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13

Greene, Tanja L. "Modular crosslinking of gelatin based thiol-norbornene hydrogels for in vitro 3D culture of hepatic cells." Thesis, ACS Biomaterials Science and Engineering, 2015. http://hdl.handle.net/1805/9929.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>As liver disease becomes more prevalent, the development of an in vitro culture system to study disease progression and its repair mechanisms is essential. Typically, 2D cultures are used to investigate liver cell (e.g., hepatocyte) function in vitro; however, hepatocytes lose function rapidly when they were isolated from the liver. This has promoted researchers to develop 3D scaffolds to recreate the natural microenvironment of hepatic cells. For example, gelatin-based hydrogels have been increasingly used to promote cell fate proce

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Baron, Matthew Graham Joesph. "Development and characterisation of a three-dimensional in vitro hepatic fish model to investigate xenobiotic metabolism." Thesis, University of Plymouth, 2014. http://hdl.handle.net/10026.1/3009.

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Regulatory and academic studies use large numbers of fish annually. The use of fish primary cells offers an in vitro alternative for the assessment of chemical toxicity and the evaluation of environmental samples in ecotoxicology. Their uses however are not without limitations which includes short culture periods (i.e. longevity and loss of organ-specific functionality over time). Three-dimensional (3-D spheroid) technology is now established for in vitro mammalian toxicity studies and offers significant advantages for environmental applications in a model fish species. This thesis reports dev

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Badee, Justine Marine. "Novel approaches to optimize assessment of hepatic uptake clearance in vitro and translation to in vivo." Thesis, University of Manchester, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701118.

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Increased use of complex cellular systems to study hepatic drug disposition in vitro has been associated with increased complexity of models applied for data analysis. Despite these advances, a tendency to under-predict transporter-mediated hepatic clearance using in vitro data is generally reported. The aim of the current project was to investigate systematically the reasons for this under-prediction. Focus of the work was on differences in quantitative expression between Organic anion-transporting polypeptide (OATP) transporters in the in vitro cellular systems and human liver tissue and the

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Laborit, Labrada Beisy. "Inhibition of dedifferentiation in primary mouse hepatocytes in vitro to generate a functional hepatic study model." Master's thesis, Université Laval, 2021. http://hdl.handle.net/20.500.11794/69373.

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L'obésité et ses pathologies associées telles que la résistance à l'insuline, le diabète de type 2 et la stéatose hépatique non-alcoolique deviennent des enjeux de santé publique. Le foie est un organe majeur dans le contrôle de l'homéostasie du glucose corporel. À l'heure actuelle, les modèles de lignées cellulaires d'hépatome sont les principaux modèles d'étude in vitro disponibles pour approfondir la physiologie hépatique. Malheureusement, l'expression et les fonctions des protéines dans ces cellules diffèrent de la réalité in vivo. Les hépatocytes primaires représentent une plateforme attr

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17

Kamo, Naoko. "Two populations of Thy1-positive mesenchymal cells regulate the in vitro maturation of hepatic progenitor cells." Kyoto University, 2007. http://hdl.handle.net/2433/135686.

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18

Geenen, Suzanne Aleida Birgitta. "Systems biology approach to understanding hepatic glutathione metabolism and its biomarkers of depletion." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/systems-biology-approach-to-understanding-hepatic-glutathione-metabolism-and-its-biomarkers-of-depletion(760cb481-d46b-494b-8aba-e8759aec025a).html.

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Drug induced liver injury is a leading cause of human illness and a major cause of drug withdrawals from the market. A systems biology approach has the potential to aid toxicology research since toxicological responses are a consequence of multiple non-linear and interdependent biological responses. Here such an approach is developed.The glutathione pathway is a key hepatic defence mechanism and deactivates reactive metabolites before they have the chance to damage cellular proteins. However, glutathione availability is limited and can vary between individuals. As hepatic glutathione levels ca

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19

Cheng, Delfine. "Structure-function properties of the gastrodigestive and hepatic systems of zebrafish (Danio rerio)." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/19797.

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While they lack mammal-specific organs, zebrafish provide a high degree of resemblance in their genetic profile, molecular mechanisms and organ physiology to humans and have been established as an excellent complementary platform to rodents. However, their use in gastroenterology and hepatology is under-utilised, conceivably due to a lack of digestive system ultrastructural details as most anatomical studies were performed by light and fluorescence imaging. This thesis provides detailed insights into the structure and function of the zebrafish digestive system, particularly the liver. Multimod

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20

Kolterud, Åsa. "The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-306.

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During embryonic development a variety of tissues and organs such as the lung, eye, and kidney are being formed. The generation of functional organs is regulated by reciprocal cell-cell interactions. Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. A central issue in organogenesis is how a cell interprets such extrinsic signals and adopts a specific fate, and how the cell in response to this signal establishes reciprocal signaling. Transcription factors play a critical role in this process and my thesis focuses on the role of the LIM-homeodom

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Kolterud, Åsa. "The role of Lhx2 during organogenesis : analysis of the hepatic, hematopoietic and olfactory systems /." Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-306.

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22

Bednarska, Aleksandra. "Artificial systems for in vitro gene expression." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLN016/document.

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L’ARN polymérase dépendante d’ADN (RNAP) est une enzyme responsable de la polymérisation de ribonucleotides dans une séquence d'ARN complémentaire de l'ADN de matrice. La famille de RNAP a plusieurs membres, comme de protéines sous-unité unique (par exemple du bactériophage T7) ou multiple sous-unité (bactériennes et eucaryotes). Transcription de l'ARN - un événement crucial dans l'expression des gènes - varie en fonction de l'origine de RNAP. Bien que le processus de transcription est relativement bien caractérisée, de nombreux éléments restent mal compris, surtout par rapport à la dynamique

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23

Wilcox, Lisa Jean. "Regulation of hepatic apolipoprotein B secretion by cholesterol and/or cholesteryl esters, in vitro and in vivo studies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ58165.pdf.

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24

Vildhede, Anna. "In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-241376.

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The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. Accurate predictions of drug CL and DDI risk from in vitro data are therefore crucial in drug development. Liver CL depends on several factors including the activities of transporters involved in the hepatic uptake and efflux. The work in this thesis a

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Izes, Aaron Michael. "Comparative studies of in vitro hepatic metabolism of mefloquine by feline microsomes and those of other selected species." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21353.

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Feline infectious peritonitis (FIP) is a systemic, fatal, viral-induced immune-mediated disease that affects cats globally. The disease is caused by virulent biotypes of feline coronaviruses (FCoV), known as the feline infectious peritonitis virus (FIPV). Traditionally, the treatment of FIP has centered on the use of immunosuppressive therapies. However, although some immunomodulatory therapeutic agents temporarily dampen clinical signs, there are no treatments that address the underlying problem of viral replication. Recent in vitro studies seeking an efficacious FCoV treatment investigated 1

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Flammang, Ann Marie. "Relative rates of hepatic and pulmonary enzyme systems involved in the metabolic fate of nicotine." Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1057253518.

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27

Eng, Heather S. "Evaluating the use of Cryopreserved Hepatocytes for the Prediction of In Vivo Hepatic Clearance." University of Toledo / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1091638312.

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28

Tascan, Ayse. "In vitro liquid culture systems of Scutellaria species." Connect to this title online, 2007. http://etd.lib.clemson.edu/documents/1181251555/.

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Erratico, Claudio. "In vitro hepatic metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and 2,2',4,4',5-pentabromodiphenyl ether (BDE-99)." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44599.

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Polybrominated diphenyl ethers (PBDEs) are flame retardants that were added to many consumer products and have emerged as persistent and bioaccumulative environmental contaminants. Penta-BDE was a commercial PBDE mixture that was used extensively in North America. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) and 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) are the dominant congeners in the Penta-BDE mixture and occur at similar levels in the mixture and in air, dust, and sediments. In contrast, the concentration of BDE-99 is 10-fold lower than that of BDE-47 in most wildlife and human samples,

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Celliere, Géraldine. "Multi-scale modeling of hepatic drug toxicity and its consequences on ammonia detoxification." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC100.

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La détoxification de l'ammoniaque est une fonction clé du foie. Récemment, il a été montré que les réactions communément admises dans ce processus étaient insuffisantes pour comprendre toutes les données expérimentales. Nous avons donc développé des explications possibles sous forme de modèles compartimentaux. Grâce à des procédures statistiques, les modèles ont été évalués et comparés. Il est apparu que l'enzyme glutamate déshydrogénase a une importance capitale dans la détoxification de l'ammoniaque. Lorsque l'on modélise des tissues, le choix de la représentation de l'espace peut influencer

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31

Jang, Mi [Verfasser], and Andreas [Akademischer Betreuer] Manz. "Microfluidic-based 3D hepatic cell cultivation as a new in vitro tool for inflammation study / Mi Jang ; Betreuer: Andreas Manz." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1152094629/34.

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Hung, Chao-Chun. "In Vitro Model Systems of a-Synuclein Over-Expression." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485237.

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Parkinson's disease (PD) is the second most common neurodegenerative disease in humans. Pathologically, it is characterised by an accumulation of proteinaceous intraneuronal inclusions termed Lewy bodies (LBs). a-Synuclein is the major protein found at the core of LBs. However, it is not known what stimulus causes inclusion formation, or whether LBs are cytotoxic. I wished to address these questions using cell-based model systems. Consequently, stable transfected nonneuronal (HEK293) and neuronal (SH-SY5Y) cell lines were generated and cells could be induced to express wild type or mutants of

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Chan, Man Yi Mandy. "Development and application of honey bee in vitro systems." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42148.

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The honey bee, Apis mellifera, has become tightly linked to human agriculture as one of the most important pollinators. The recent honey bee population decline has raised global concerns of a pollination crisis, yet honey bee research lags far behind in available research tools compared to other model organisms, limiting the pace we can hope to advance our knowledge of honey bee biology and improve bee health. Therefore, the major goal of this thesis was to establish new tools and to improve some of the existing tools for honey bee research and then to demonstrate that these tools can be combi

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Gartlon, Joanne. "Detection of neurotoxicity using in vitro neuronal cell systems." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417115.

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Kimble, Benjamin. "Pharmacokinetic aspects of meloxicam in koalas: including its hepatic microsomal metabolism compared with other selected species." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13996.

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Prior to this research, no disposition studies of meloxicam (nor any other non steroidal anti-inflammatory drugs) had been conducted in koalas (a specialist Eucalyptus spp. foliage feeder) despite being readily administered to this species, in the field. Thus, aspects of the in-vivo pharmacokinetic profile of meloxicam in the koala and the in-vitro metabolism of meloxicam in the koala and selected species were investigated. In the first stage of the research, a simple, sensitive and improved method using high performance liquid chromatography equipped with photo diode array detection was deve

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Mulder, Jaap. "Towards treatment of cholestatic liver disease in children via interference with transcriptional regulation of hepatic transport systems." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/.

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Mossberg, Anneli. "Improving the Modeling Framework for DCE-MRI Data in Hepatic Function Evaluation." Thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-94306.

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Background Mathematical modeling combined with prior knowledge of the pharmacokinetics of the liver specific contrast agent Gd-EOB-DTPA has the potential to extract more information from Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) data than previously possible. The ultimate goal of that work is to create a liver model that can describe DCE-MRI data well enough to be used as a diagnostic tool in liver function evaluation. Thus far this goal has not been fully reached and there is still some work to be done in this area. In this thesis, an already existing liver model will be

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Tirnitz-Parker, Janina Elke Eleonore. "Primary culture and immortal cell lines as in vitro models to evaluate the role of TWEAK signalling in hepatic oval cells /." Connect to this title, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0039.

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BERARDO, CLARISSA ANGELA IRIS. "MPEP, a metabotropic Glutamate Receptor 5 (mGluR5) negative allosteric modulator, protects from hepatic ischemic injury both in vitro and ex vivo." Doctoral thesis, Università degli studi di Pavia, 2018. http://hdl.handle.net/11571/1214799.

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Cox, Julie. "Evaluation of Strategies to Improve In Vitro Mutagenicity Assessment: Alternative Sources of S9 Exogenous Metabolic Activation and the Development of an In Vitro Assay Based on MutaMouse Primary Hepatocytes." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39340.

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In vitro genetic toxicity tests using cultured bacterial or mammalian cells provide a cost- and time-effective alternative to animal tests. Unfortunately, existing in vitro assays are not always reliable. This is in part due to the limited metabolic capacity of the cells used, which is often critical to accurately assess chemical genotoxicity. This limited metabolic capacity necessitates the use of exogenous sources of mammalian metabolic enzymes that can simulate in vivo mammalian metabolic activation reactions. In response to this, and other limitations, alongside the worldwide trend to redu

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Nelson, T. J. "In vitro culture of Theobroma cacao L." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376391.

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Karlsson, Elin Sofia. "Prediction of metabolic clearance by glucuronidation using in vitro systems." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493442.

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In drug development, ADME issues are still large contributors to drug attrition. The use of in vitro systems, such as microsomes and hepatocytes, for the assessment of metabolic stability and prediction of in vivo clearance, are well established for substrates of the cytochrome P450 enzymes (CYPs). However, these systems have been less explored for conjugation reactions, such as glucuronidation by uridine diphosphate glucuronosyltransferases (UGTs). The aim of this study was to increase the understanding of glucuronidation kinetics in vitro and the factors influencing the prediction of metabol

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Haverkos, Stephen M. "FRICTIONAL PROPERTIES OF NOVEL BRACKET SYSTEMS: AN IN-VITRO STUDY." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5770.

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Orthodontic brackets undergo resistance during sliding that includes classical friction, binding, and notching. Current bracket systems are hampered by these challenging forces. As a result, the clinician usually needs to apply additional forces to overcome the resistance which increases the risk of root resorption and discomfort for the patient. This study evaluated frictional properties of a novel bracket that had polytetrafluoroethylene (Teflon™) coated rollers in its design. Five types of brackets (n = 10, each), including a passive self-ligating bracket, a traditional ligated bracket, a t

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NASELLI, Flores. "NUTRIGENOMICS EFFECTS OF PHYTOCHEMICAL INDICAXANTHIN IN in vitro CELL SYSTEMS." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/90899.

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Nutrition plays a key role in many aspects of health, indeed epidemiological studies provide evidence that diet can play essential roles in reducing the risk of chronic diseases. Accumulating evidence indicates that dietary compounds (phytochemicals) from fruit and vegetables can modulate multiple cancer-inflammation pathways which are relevant for chemoprevention and are commonly deregulated by epigenetic mechanisms in cancer cells, including drug detoxification, cell cycle regulation, apoptosis induction. Epigenetic refers to heritable alterations in gene expression that do not involve

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MOSCHINI, ELISA. "Nanoparticles: biological effects on in vitro and in vivo systems." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/29889.

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The advent of nanotechnology and the commercialization of several nanoparticle-containing products call to a serious assessment of the environmental and human risks derived from the exposure to these new materials. The emerging properties, the increasing world market and the several exposure scenarios are some of the main criticisms related to distribution of these products. Among nanomaterials metal oxides nanoparticles are considered at the same time an interesting and critical group; in particular titanium dioxide, zinc oxide and cupric oxide (nTiO2, nZnO, nCuO) have received particular at

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Sjögren, Erik. "Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132571.

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The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. Disposition is the expression used to encapsulate both elimination and distribution. This thesis presents novel approaches and models based on simple in vitro systems for the investigation of processes involved in the hepatic drug disposition. An approach to the estimation of enzyme kinetics based on su

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Bruschi, Sam A. "Investigations into mechanisms of paracetamol-induced toxicity using ìn vitro' systems /." Title page, abstract and table of contents only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phb192.pdf.

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McDougall, Craig. "Advanced photonic methodologies for the 'in vitro' manipulation of cellular systems." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1876.

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This thesis investigates the application of a variety of optical techniques for the manipulation of single cells and their local micro-environment. The methodologies developed provide enhanced control over a single cell under study affording exquisite spatial and temporal control over biological processes of interest. The work presented within the thesis can be split into three distinct categories. The first of these provides an investigation in light activated “caged” molecular probes. This work generated several new compounds which were then applied to providing control over processes involv

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Sassano, Emily. "Role of regulatory T cells in in vitro human culture systems." Honors in the Major Thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1046.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Burnett College of Biomedical Sciences<br>Molecular and Microbiology

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Richards, Jemma. "Antidepressants and gene expression : in vitro studies in model cell systems." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275231.

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