Relevant bibliographies by topics / In-Vitro Release Kinetics

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'In-Vitro Release Kinetics'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "In-Vitro Release Kinetics"

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Kumar, Putta Rajesh, Meena N, Poojitha P, Sowjanya P, Shivaleela U, and Sharma JVC. "Formulation Design and in Vitro Evaluation Studies of Antidepressant Venlafaxine Hydrochloride Oral Drug Delivery Systems." Journal of Biomedical and Pharmaceutical Research 13, no. 2 (2024): 51–63. http://dx.doi.org/10.32553/jbpr.v13i2.1084.

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Background: Venlafaxine Hydrochloride a serotonin, nor epinephrine reuptake inhibitor, oral antidepressant used to treat depression. Objective: The present study was aimed at studying controlled release of Venlafaxine Hydrochloride with Guargum, Hydroxy propyl methyl cellulose as matrix polymers, Micro crystalline cellulose as binder and Dicalcium phosphate as diluent filler. Methods: Tablets were studied for pre, post compression, swelling and in vitro dissolution studies. Drug release was analyzed by release kinetic models. Results: Preformulation studies revealed that the drug procured was
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Arefin, Paroma, Ikramul Hasan, Md Shfiqul Islam, and Md Selim Reza. "Formulation and In vitro Evaluation of Eudragit RL 100 Loaded Fexofenadine HCl Microspheres." Bangladesh Pharmaceutical Journal 19, no. 1 (2016): 58–67. http://dx.doi.org/10.3329/bpj.v19i1.29240.

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The present study deals with the formulation and evaluation of Fexofenadine hydrochloride (HCl) loaded sustained release microspheres by emulsion solvent evaporation method with Eudragit RL 100. The effects of percent drug loading on drug encapsulation efficiency, drug content and drug release rate were assessed. In vitro dissolution study was performed spectrophotometrically according to USP paddle method using phosphate buffer (pH 6.8) for 10 hours. The release rate of Fexofenadine HCl from the microspheres was significantly increased with the increase of drug loading. The drug release patte
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Jakobek, Lidija, Jozo Ištuk, Andrew R. Barron, and Petra Matić. "Bioactive Phenolic Compounds from Apples during Simulated In Vitro Gastrointestinal Digestion: Kinetics of Their Release." Applied Sciences 13, no. 14 (2023): 8434. http://dx.doi.org/10.3390/app13148434.

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Bioactive phenolic compounds in their natural form show beneficial effects on the gastrointestinal system. The kinetics of their release are important for understanding those effects. The aim was to study the kinetics of the release of phenolic compounds from apples during in vitro simulated gastrointestinal digestion by using modified equations of first- and second-order kinetics. 35% and 67% of total phenolic compounds were released in the gastric phase, and 26% and 27% in the intestinal phase (peel and flesh, respectively). Intensive release of anthocyanins, flavan-3-ols, dihydrochalcones,
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Kabir, Abul Kalam Lutful, Shimul Halder, and Abu Shara Shamsur Rouf. "In vitro Release Kinetic Study of Theophylline from Kollidon SR Polymer Based Matrix Tablet." Dhaka University Journal of Pharmaceutical Sciences 14, no. 1 (2015): 43–48. http://dx.doi.org/10.3329/dujps.v14i1.23734.

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Controlled release tablet matrix of theophylline was prepared with kollidon SR, a spray dried powder grade polymer (polyvinyl acetate and povidone based matrix rate retarding hydrophobic materials) by utilizing direct compression technique. Different proportion of kollidon SR was used to develop the matrix builder in the five proposed formulations (F-1 to F-5) for the study of release rate retardant effect at 10, 12, 15, 18 and 21% of total weight of matrix tablet, respectively. The in vitro dissolution study of the matrices of those proposed tablet formulations were carried out in simulated g
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Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre
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Das, Utpal, Shimul Halder, Abul Kalam Lutful Kabir, Harun Or Rashid, and Abu Shara Shamsur Rouf. "Development and in vitro Evaluation of Sustained Release Matrix Tablets of Indapamide from Methocel® K15 MCR and K100 LVCR." Dhaka University Journal of Pharmaceutical Sciences 10, no. 2 (2012): 87–92. http://dx.doi.org/10.3329/dujps.v10i2.11785.

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Indapamide, a low-dose thiazide-type diuretic, is used for the treatment of essential hypertension. In this study, we developed an indapamide sustained release formulation using Methocel K15 MCR (a modified hydroxypropyl methylcellulose), Methocel K100 LVCR (a modified hydroxypropyl methylcellulose), magnesium stearate, talc and starch 1500 by direct compression. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity etc. The tablets were subjected to thickness, weight variation test, hardness, friability and
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Ruan, Xiangchun, Jidong Hu, Lianshou Lu, et al. "Poloxamer 407/188 Binary Thermosensitive Gel as a Moxidectin Delivery System: In Vitro Release and In Vivo Evaluation." Molecules 27, no. 10 (2022): 3063. http://dx.doi.org/10.3390/molecules27103063.

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Moxidectin (MXD) is an antiparasitic drug used extensively in veterinary clinics. In this study, to develop a new formulation of MXD, a thermosensitive gel of MXD (MXD-TG) was prepared based on poloxamer 407/188. Furthermore, the gelation temperature, the stability, in vitro release kinetics and in vivo pharmacokinetics of MXD-TG were evaluated. The results showed that the gelation temperature was approximately 27 °C. MXD-TG was physically stable and can be released continuously for more than 96 h in vitro. The Korsmeyer–Peppas model provided the best fit to the release kinetics, and the relea
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Dias, Susana, António Mata, João Silveira, et al. "Hydrogen Peroxide Release Kinetics of Four Tooth Whitening Products—In Vitro Study." Materials 14, no. 24 (2021): 7597. http://dx.doi.org/10.3390/ma14247597.

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Tooth whitening efficacy can be influenced by several factors, of which concentration and application time are two of the most important. This in vitro study aimed to evaluate the initial content and release kinetics of the hydrogen peroxide (HP) content, or the carbamide peroxide (CP) content as converted to its HP equivalent, of four tooth whitening products with different concentrations (6% HP, 16% CP, 10% CP, and 5% CP). Titrations with Cerium Sulphate IV were performed to determine HP concentration. HP release kinetics were evaluated by a spectrophotometric technique. The results were exp
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Yefimova, S. L. "In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes." Functional materials 22, no. 2 (2015): 199–206. http://dx.doi.org/10.15407/fm22.02.199.

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Shuma, Madhabi Lata, Bishyajit Kumar Biswas, Sheikh Zahir Raihan, and Shimul Halder. "In vitro Comparative Dissolution Studies of Different Propranolol Generic Tablets Available in Bangladesh." Journal of Drug Delivery and Therapeutics 11, no. 6-S (2021): 86–91. http://dx.doi.org/10.22270/jddt.v11i6-s.5225.

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The present study focused to assess in vitro dissolution profiles of four different products of propranolol 10 mg Tablets (Randomly coded as PRP1-PRP4) available in Bangladesh comparing with the reference brand (coded as REF). Propranolol is a competitive non selective beta-adrenergic receptor antagonist used to amend or restore normal heart rhythm in cardiovascular diseases. An in vitro dissolution study was carried out using the United States Pharmacopoeia (USP) paddle method at 75 rpm with 500 mL of 0.1N HCl dissolution media at 37.0± 0.5 0C. All the tested locally manufactured propranolol
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Dissertations / Theses on the topic "In-Vitro Release Kinetics"

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Barrios, Jerusa Goi. "DESENVOLVIMENTO E CARACTERIZAÇÃO DE SUSPENSÕES CONTENDO NANOCÁPSULAS DE ADAPALENO COM DIFERENTES NÚCLEOS OLEOSOS." Centro Universitário Franciscano, 2010. http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/482.

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Submitted by MARCIA ROVADOSCHI (marciar@unifra.br) on 2018-08-15T13:27:18Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_JerusaGoiBarrios.pdf: 2507299 bytes, checksum: b0357f55d1ddf8dd63d987592cf16a6e (MD5)<br>Made available in DSpace on 2018-08-15T13:27:18Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_JerusaGoiBarrios.pdf: 2507299 bytes, checksum: b0357f55d1ddf8dd63d987592cf16a6e (MD5) Previous issue date: 2010-06-30<br>Acne is one of the most common inflammatory condi
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Midander, Klara. "Metal Particles – Hazard or Risk? Elaboration and Implementation of a Research Strategy from a Surface and Corrosion Perspective." Doctoral thesis, Stockholm : Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11695.

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KOCERGINSKY, Patrícia de Oliveira. "Criptococose e determinação do efeito antifúngico in vitro e in vivo por sistema de liberação controlada com ciclopirox olamina." Universidade Federal de Pernambuco, 2013. https://repositorio.ufpe.br/handle/123456789/18294.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-02-13T13:18:57Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE colação de grau.pdf: 1971286 bytes, checksum: 680d0e24d2f0efbe0313ab8752f1cc93 (MD5)<br>Made available in DSpace on 2017-02-13T13:18:57Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE colação de grau.pdf: 1971286 bytes, checksum: 680d0e24d2f0efbe0313ab8752f1cc93 (MD5) Previous issue date: 2013-02-22<br>CNPq<br>A criptococose é uma infecção fún
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Jacob, Dolly. "Investigation into reliability and performance of an implantable closed-loop insulin delivery device." Thesis, De Montfort University, 2014. http://hdl.handle.net/2086/11126.

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An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied for future clinical use. Investigations into the device material compatibility with insulin solution, assessed by monitoring insulin loss and degradant formation over a period of 31 days using RP-HPLC have shown that stainless steel and titanium are the most compatible materials. Polycarbonate contribu
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Syarifuddin, Adiansyah. "Multi sensory integration as a strategy to compensate for sodium and fat reduction in food." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS088.

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Au cours des dernières années, les autorités sanitaires ont recommandé une réduction de la teneur en sel et en gras dans la consommation alimentaire quotidienne. Cependant, les aliments à teneur réduite en sel et en gras sont souvent peu appréciés par les consommateurs, ce qui a amené au développement des recherches sur les stratégies possibles pour maintenir l’acceptabilité des aliments tout en réduisant les teneurs en ces ingrédients. Dans cette thèse, l’intégration multi-sensorielle et les cinétiques de libération du sel et des arômes mesurées in vitro ont été étudiés pour évaluer leur pote
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Wu, Chao-Ting, and 吳兆婷. "Preparation, characterization and in vitro release kinetics of nanostructured lipid carriers." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/26480504755040709517.

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碩士<br>長庚大學<br>生化與生醫工程研究所<br>94<br>The purpose of this research was to discuss the preparation, characteristic and application of nanostructured lipid carriers（NLC）, moreover, the influence of compared with another carrier system（nanoemulsion, NE）on the rate of drug release was studied. This study was loaded with lutein and vitamin K1, respectively. We utilizing nanoparticle technique to loaded with lipophilic drugs in the solid lipids, which protected lipophilic drugs from degradation and enhance stability of drugs. High melting temperature combined with ultrasonic method was used to prepare n
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Yang, S., X. Yin, C. Wang, et al. "Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile." 2014. http://hdl.handle.net/10454/10557.

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No<br>Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron radiation X-ray computed microtomography (SR-muCT) and a sensitive LC/MS/MS method. The purpose of this article is to introduce a powerful, non-invasive and quantitative technique for studying individual pellet microstructures and to investigate the relationship between the microstructure and drug release from
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Books on the topic "In-Vitro Release Kinetics"

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McElvain, James Scott. In vitro studies of the kinetics of endogenous dopamine release and reuptake into rat striatal suspensions using rotating disk electrode voltammetry. 1992.

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Parsons, James Frank. Toxic effects in macrophage and mast cell preparations perifused in vitro: Continuous recording of morphologicalchanges and enzyme and mediator release kinetics in the study of rat mast cellresponses to compound 48/80 and particulate cytotoxity in mouse peritoneal macrophages. 1986.

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Book chapters on the topic "In-Vitro Release Kinetics"

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Rajan, Aswni Sundara, Kerensa Miriam Sheen, Balaji Sadhasivam, and Nachimuthu Saraswathy. "In-Vitro Wound Healing and Release Kinetics of β-Cyclodextrin Encapsulated Curcumin Loaded Carrageenan Hydrogel Film: An Efficient Wound Dressing Material." In Proceedings of the International Conference on Nanomedicine (ICON-2019). Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-25135-2_11.

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Sinha, Mansi. "In Vitro Dissolution and In Vitro-In Vivo Correlation." In Computer Aided Drug Development. THINKPLUS PHARMA PUBLICATIONS, 2024. http://dx.doi.org/10.69613/7q2gpa47.

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The integration of computational systems in dissolution testing and in vitro-in vivo correlation (IVIVC) has revolutionized pharmaceutical development and quality control processes. Advanced software platforms enable automated data collection, analysis, and interpretation of dissolution profiles while facilitating real-time monitoring of drug release kinetics. Machine learning applications enhance the accuracy of dissolution profile comparisons and improve the prediction of in vivo drug behavior based on in vitro data. Automated systems handle large datasets from multiple dissolution tests, pe
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Shirode, Devendra S., Vaibhav R. Vaidya, and Shilpa P. Chaudhari. "Computational Tools to Predict Drug Release Kinetics in Solid Oral Dosage Forms." In Software and Programming Tools in Pharmaceutical Research. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815223019124010013.

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Dissolution is the concentration of a drug that goes into solution per unit of time under standard conditions of solid-liquid interface, temperature, and composition of solvent. In the pharmaceutical industry, in vitro dissolution testing has been established as a preferred method to evaluate the development potential of new APIs and drug formulations and to select the most appropriate solid form for further development. Dissolution allows the measurement of some important physical parameters, like drug diffusion coefficient, and is also used in model fitting on experimental release data. Kine
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Bin Zafar Auniq, Reedwan, Namon Hirun, and Upsorn Boonyang. "Three-Dimensionally Ordered Macroporous-Mesoporous Bioactive Glass Ceramics for Drug Delivery Capacity and Evaluation of Drug Release." In Ceramic Materials [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.95290.

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Bioactive glass ceramics (BGCs) have been used in orthopedic and dentistry due to having better osteoconductive and osteostimulative properties. This study aimed to evaluate and compare the drug release properties of two different BGCs; 45S5 and S53P4. The BGCs were composed with four phases of SiO2 – CaO – Na2O – P2O5 system, synthesized by sol–gel method using dual templates; a block-copolymer as mesoporous templates and polymer colloidal crystals as macroporous templates, called three-dimensionally ordered macroporous-mesoporous bioactive glass ceramics (3DOM-MBGCs). In vitro bioactivity te
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Arvapalli, A. Swarupa, and B. Anka Rao Areti. "Design, Development and Characterization of Eberconazole Proniosomes." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00329.

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Eberconazole (EBZ) is a BCS class?II?drug that has poor solubility and high permeability. Aim of the present research work is to prepare and evaluate Eberconazole Proniosomes. Proniosomes were prepared by thin-film hydration method ratios of nonionic surfactant with cholesterol and keeping drug and DCP constant. Multilamellar Proniosome were prepared by the thin-film hydration method. Accurately weighed quantities of drug, surfactant (Span), and CHOL were dissolved in chloroform in a round-bottom flask. DCP were added to each formulation as a negative charge-inducing agent. The chloroform was
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Singhal, Peeush, Rajneesh Dutt Kaushik, and Vijay Jyoti Kumar. "Preparation and in vitro Characterisation of Solid Dispersion Floating Tablet by Effervescent Control Release Technique with Improved Floating Capabilities." In Molecular Pharmacology. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.92187.

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In this research, an effort has been done for the development of effervescent controlled release floating tablet (ECRFT) from solid dispersions (SDs) of diclofenac sodium (DS) for upsurge the solubility and dissolution rate. ECRFT of DS was prepared by using SDs of DS and its SDs prepared with PEG as carrier using thermal method (simple fusion). SDs of DS was formulated in many ratios (1:1, 1:2, 1:3 and 1:4). Prepared SDs were optimised for its solubility, % drug content and % dissolution studies. Tablets were formulated by using optimised SDs products and all formulation was evaluated for var
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Kulinowski, P., and P. DoroŻyŃski. "Applications of MRI to Study Controlled Drug Release Formulations: From Model Formulations Toward the Understanding of Drug Products Behavior." In Magnetic Resonance and its Applications in Drug Formulation and Delivery. Royal Society of Chemistry, 2024. http://dx.doi.org/10.1039/9781788019996-00333.

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Magnetic resonance (MR) imaging is a flexible, multimodal technique with a plethora of imaging pulse sequences and their possible modifications. The goal of the chapter is to give researchers who work in the field of drug development, manufacturing, and formulation some hints concerning the applicability of MR imaging techniques to solve technological issues. Application of MR imaging (1) can give spatio-temporal characteristics of the controlled release formulations during hydration/dissolution; (2) can help to explain of mechanisms of matrix hydration and drug dissolution; (3) can explain so
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Sharma, Sandeep, Shailja Sharma, Ruchi Sharma, and Bhaskar Sharma. "Graphene–Metal Oxide Composite Materials for Biomedical Applications." In Graphene–Metal Oxide Composites. Royal Society of Chemistry, 2025. https://doi.org/10.1039/9781837673391-00439.

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Over the past decade, owing to their highly enriched physiochemical properties, graphene-based metal oxide composites have been explored for various applications in the medical field. Due to its high surface area, easy functionalization, and ability to penetrate cell-membranes, graphene is becoming a promising candidate for bio-delivery carriers. Additionally, graphene-based materials are reported to be suitable carriers to overcome the disadvantages associated with conventional drug formulation. Moreover, various metals and their oxides could be coupled with graphene to form graphene–metal ox
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Veenadevi, A., P. Srinivasa Babu, and Pallavi Kurra. "Development and Optimization of Niosomes for Brain Targeting Using Response Surface Methodology." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00477.

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The current research work deals with the combination of surfactants for vesicular drug delivery of potent chemotherapeutic drugs like capecitabine with advantages of controlled release as well as brain specific targeting. Niosomes formulation was optimized by employing a surface response method in which central composite designed was selected for getting a less number of formulations with better results using Design Expert software version V 11. The niosomes were formulated by using combination of span-80 and brij-78 as non-ionic surfactant by thin film hydration technique in which cholesterol
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Kumar, Keshav, Dr Rupali Sharma, Dr Satish Sardana, Mr Shekhar Sharma, and Dr M. Aamir Mirza. "DOSAGE FORM DESIGN." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 14. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkpn14p1ch6.

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The design of dosage forms is a pivotal endeavour within the realm of pharmaceutical sciences, encompassing the intricate interplay between active pharmaceutical ingredients (APIs) and formulation components to achieve optimal therapeutic outcomes. This chapter delves into the multifaceted landscape of dosage form design, exploring the nuanced considerations that underpin the creation of effective, safe, and patient-centric drug delivery systems. Commencing with an introduction to dosage forms, the chapter elucidates the critical role they play in pharmaceuticals, encapsulating a diverse spect
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Conference papers on the topic "In-Vitro Release Kinetics"

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Asemani, Davud, Anjan Motamarry, and Dieter Haemmerich. "In vitro Measurement of Release Kinetics of Temperature Sensitive Liposomes with a Fluorescence Imaging System." In 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2018. http://dx.doi.org/10.1109/embc.2018.8512942.

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Berchane, Nader S., Kenneth H. Carson, Allison C. Rice-Ficht, and Malcolm J. Andrews. "Investigation of Drug Release From Biodegradable PLG Microspheres: Experiment and Theory." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176030.

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Piroxicam containing PLG microspheres having different size distributions were fabricated, and in vitro release kinetics were determined for each preparation. Based on the experimental results, a suitable mathematical theory has been developed that incorporates the effect of microsphere size distribution and polymer degradation on drug release. We show from in vitro release experiments that microsphere size has a significant effect on drug release rate. The initial release rate decreased with an increase in microsphere size. In addition, the release profile changed from first order to concave-
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Bonani, Walter, Claudio Migliaresi, and Wei Tan. "Nanofiber Micropatterns for Controlled Release of Biomolecules." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53816.

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Essential to growing or regenerating 3-dimensional tissues is the formation of functional microcirculation that provides nutrients, oxygen and signal molecules for tissue survival and function regeneration. In the past decade, molecule-based microvascular formation has been achieved in vitro and in vivo. However, direct delivery of angiogenic molecules often results in malformed hyperpermeable microvessels, microvessels with low density. This can be attributed to the lack of effective molecule mechanisms that regulate vascular formation. More recent studies utilize biodegradable materials to c
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Kluge, Jonathan A., Rudra A. Pampati, Mara L. Schenker, et al. "Delivery of Active FGF-2 From Mechanically-Stable Biological Nanofibers Accelerates Cell Ingress Into Multifiber Composites." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53955.

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Fibrocartilaginous tissues such as the meniscus and annulus fibrosus serve critical load-bearing roles, relying on arrays of highly organized collagen fibers to resist tensile loads [1]. As these specialized structures are often injured, there exists great demand for engineered tissues for repair or replacement. Cell-laden aligned nanofibrous scaffolds formed from poly(ε-caprolactone) (PCL) have shown promise in achieving tissuelike mechanical and biochemical properties and can direct cellular and matrix organization in vitro [2]. A current limitation of nanofibrous scaffolds, however, is a sl
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Blanco, Elvin, Takafumi Sangai, Funda Meric-Bernstam, and Mauro Ferrari. "Chemotherapeutic Synergy Enhancement Through Micellar Nanotherapeutics." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13263.

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Current chemotherapeutic regimens involve the administration of a combination of agents with hopes of gaining synergistic cell-killing effects observed in vitro. However, drug synergy is rarely realized clinically given the different pharmacokinetic profiles of the drugs. Recent findings show that a combination of rapamycin and paclitaxel proves highly effective at hindering growth of tumors wherein the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. Our objective was to fabricate a micellar nanotherapeutic platform capable of delivering a multitude of ag
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Marin, Maria-Minodora, Madalina Georgiana Albu Kaya, Mihaela Violeta Ghica, et al. "Design and evaluation of doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration." In The 8th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2020. http://dx.doi.org/10.24264/icams-2020.ii.16.

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Cartilage damage is difficult to self-heal due to an avascular microenvironment and distinct mechanical properties. These features are a challenge in designing a cartilaginous tissue with repairing effect without producing any local infections. Thus, a biodegradable scaffold in which the drug can be incorporated is preferable. Drug delivery systems based on collagen sponges have progressively become remarkable biomaterials for different medical applications. The aim of this work was to design and characterize some collagen/chondroitin sulfate supports with doxycycline for cartilage tissue rege
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Yeung, Edward S., Wei Tong, and Sheri Lillard. "Cell Imaging by Laser-Induced Native Fluorescence Microscopy." In Laser Applications to Chemical and Environmental Analysis. Optica Publishing Group, 1998. http://dx.doi.org/10.1364/lacea.1998.lma.2.

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The high degree of heterogeneity of the nervous and endocrine systems makes it extremely important for real-time monitoring of dynamic chemical changes at the single-cell level to gain a better understanding of the interaction of cells with their environment. Secretion mediated by exocytosis is one of the fundamental phenomena whose mechanism mimics the release of neurotransmitters at synaptic sites. Although the regulation of the secretory pathway has been studied extensively, its molecular mechanism is still not clear. It is important to develop methods that can follow real-time secretory pr
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Nontasirichayakul, Chanicha, Chutima Wiranidchapong, Worapan Sithithaworn, and Duangratana Shuwisitkul. "Optimization of Formulation Variables Using Central Composite Design to Enhance Andrographolide Release from <i>Andrographis paniculata</i> Extract-Chitosan Solid Dispersion." In 5th International Conference and Exhibition on Pharmaceutical Sciences and Technology 2022. Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-3xj8r7.

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Andrographolide (AGP), a major component of Andrographis paniculata (Burm.f.) Nees (AP), has several biological activities. Nevertheless, poorly water solubility and low bioavailability of AGP lead to decrease clinical benefits. Therefore, this study aims to develop of AP extract-chitosan solid dispersion using central composite design (CCD) to enhance AGP release. AP crude extract was obtained by Soxhlet extractor using 85%v/v ethanol as a solvent extraction. Then, AP extract, chitosan, and poloxamer 188 in the concentrations provided by CCD was spray dried. The in-vitro release of AP extract
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Mendygarin, Yertay, Luis R. Rojas-Solórzano, Nurassyl Kussaiyn, Rakhim Supiyev, and Mansur Zhussupbekov. "Eulerian-Eulerian Multiphase Modeling of Blood Cells Segregation in Flow Through Microtubes." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70850.

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Cardiovascular Diseases, the common name for various Heart Diseases, are responsible for nearly 17.3 million deaths annually and remain the leading global cause of death in the world. It is estimated that this number will grow to more than 23.6 million by 2030, with almost 80% of all cases taking place in low and middle income countries. Surgical treatment of these diseases involves the use of blood-wetted devices, whose relatively recent development has given rise to numerous possibilities for design improvements. However, blood can be damaged when flowing through these devices due to the lac
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Reports on the topic "In-Vitro Release Kinetics"

1

Chutimaworapan, Suchada, Chaiyo Chaichantippayuth, and Areerat Laopaksa. Formulation of pharmaceutical products of Garcinia mangostana Linn. extracts. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.32.

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Part I: The purpose of the investigation was to develop the extraction process that was simple, practical and giving high yield. The maceration of dried powder of Garcinia mangostana fruit husk with ethyl acetate gave yellow crystalline powder of mangostin. The yield was calculated as 7.47%. The identification of the Garcinia mangostanahusk extract was carried out by thin-layer chromatography (TLC) and differential scanning calorimetry. The TLC of mangostin was done by using the alumina sheet and ethyl acetate: hexane (3:1) as mobile phase. The Rf value as compared with standard mangostin was
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