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Journal articles on the topic 'In-Vitro Testing of Quick Dissolving Tablets'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Aarti, Nimse* Dr. Sachin Kale Dr. K. R. Biyani. "Formulation And In-Vitro Testing of Quick Dissolving Tablets of Nsaids Drug Along with Musa Paradisiaca Powder." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3468–73. https://doi.org/10.5281/zenodo.15475438.

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Lornoxicam is a non-steroidal anti-inflammatory medication commonly used as an anti-inflammatory, analgesic and antipyretic agent.  Conventional solid dosage forms are frequently linked to a faster disintegration time, but oral bioavailability is poor, with only 50% of the dose reaching systemic circulation due to substantial first pass metabolism.  Because the banana powder in the fast-dissolving tablets dissolves quickly, the medication is released right away. Two to four hours is the elimination half-life.  For patients at high risk of developing NSAID-induced stomach and duo

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Kaur, Manpreet, Amit Mittal, Monica Gulati, Deepika Sharma, and Rajesh Kumar. "Formulation and in vitro Evaluation of Fast Dissolving Tablets of Febuxostat Using Co-Processed Excipients." Recent Patents on Drug Delivery & Formulation 14, no. 1 (2020): 48–62. http://dx.doi.org/10.2174/1872211314666191224121044.

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Background: Febuxostat is a novel, orally-administered, powerful, non-purine, xanthine oxidase inhibitor used for treating gout and ceaseless tophaceous gout. The drug exhibits low bioavailability (about 49%) which is ascribed to its dissolution rate-limited absorption. Objective: The current work is aimed to provide a novel strategy to improve the dissolution profile and thus, the bioavailability of Febuxostat. Methods: Formulation of Fast Dissolving Tablets (FDT) is anticipated to provide immediate release of the drug, which in turn, will improve its dissolution profile to provide the initia

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Ali, Hany S. M., Sameh A. Ahmed, Abdulmalik A. Alqurshi, Ali M. Alalawi, Ahmed M. Shehata, and Yaser M. Alahmadi. "Tadalafil-Loaded Self-Nanoemulsifying Chewable Tablets for Improved Bioavailability: Design, In Vitro, and In Vivo Testing." Pharmaceutics 14, no. 9 (2022): 1927. http://dx.doi.org/10.3390/pharmaceutics14091927.

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This research aimed to develop innovative self-nanoemulsifying chewable tablets (SNECT) to increase oral bioavailability of tadalafil (TDL), a nearly insoluble phosphodiesterase-5 inhibitor. Cinnamon essential oil, PEG 40 hydrogenated castor oil (Cremophor® RH 40), and polyethylene glycol 400 served as the oil, surfactant, and cosurfactant in the nanoemulsifying system, respectively. Primary liquid self-nanoemulsifying delivery systems (L-SNEDDS) were designed using phase diagrams and tested for dispersibility, droplet size, self-emulsifying capability, and thermodynamic stability. Adsorption

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Prajapati, Vinitbhai*1 Himanshu Sharma2 Sagar Patra3 Sahilahmad Makarani3 Mahendrakumar Dubey1. "A Contemporary Approach to The Medicate Conveyane Through Orodispersible Tablets." International Journal of Scientific Research and Technology 1, no. 12 (2024): 29–40. https://doi.org/10.5281/zenodo.14285188.

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The development of dosage forms that are easy to manufacture and administer, as well as rapid release and increased bioavailability, have led to new drug delivery systems. To achieve the desired result, drugs must be delivered to the site of action at a speed and concentration that maximizes therapeutic benefits and minimizes side effects. The most popular and efficient way of drug administration is oral. Recently, many medicinal products have been released in the market. The use of lyophilizers and oral tablets or films have expanded treatment options. Both children and adults can benefit fro

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Panjwani, Alysha, Yong Zhu, Keiichiro Kushiro, Sam Lai, and Kathleen Vincent. "Sheep Postcoital Testing to Evaluate Antibody-Based, Nonhormonal Contraceptive Tablet [ID 1459]." Obstetrics & Gynecology 145, no. 6S (2025): 64S. https://doi.org/10.1097/aog.0000000000005918.020.

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INTRODUCTION: Efficacy of on-demand nonhormonal contraception that targets and disables progressively motile sperm (PMS) can be studied through surrogate postcoital testing (PCT) in sheep models, due to similarities to human reproductive tract size and anatomy. We utilized PCT to assess the contraceptive potential of anti-sperm antibody in tablet form in vivo in sheep. METHODS: Pooled semen from five prescreened human male donors was collected and evaluated for adequate motility prior to use. Ewes (n=6) were given a quick-dissolving tablet delivering active anti-sperm antibody, a placebo table

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Patil, Shailesh B., and Jitendra D. More. "Expansion and Valuation of Naproxen Sodium Fast Dissolving Tablet." Journal of Pharmaceutical Research 23, no. 3 (2024): 178–88. http://dx.doi.org/10.18579/jopcr/v23.3.98.

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The evaluation of Naproxen Sodium Fast Dissolving Tablets emphasizes the critical role of careful formulation design and thorough testing in pharmaceutical development. Among the formulations, F7 demonstrated outstanding properties, including excellent flow characteristics and optimal tablet hardness. Stability testing over a four-week period showed consistent performance, though minor variations in tablet attributes were observed. Continuous monitoring is advised to ensure sustained efficacy. The in-vitro release profile revealed rapid disintegration and dissolution, crucial for prompt drug r

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Bindal, Rishabh, and Arpna Indurkhya. "Formulation and Evaluation of Ketorolac Tromethamine Mouth Dissolving Tablets." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 60–64. http://dx.doi.org/10.22270/jddt.v11i1.4502.

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Due to more versatility and comfort, mouth dissolving tablets are the most advanced type of oral solid dosage forms. Compared to conventional tablets, it increases the effectiveness of APIs by dissolving within a minute in the oral cavity after contact with less saliva, without chewing and without the need for water for administration. Mouth Dissolving Tablets of Ketorolac tromethamine were prepared by direct compression method using various superdisintegrants like crospovidone, Croscarmellose sodium, and Sodium starch glycolate in different concentrations. Prepared tablets were evaluated for

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8

Gurram, Syam Sundar, Nagaveni P, and Sreevalli Arigela. "Formulation and evaluation of nifedipine fast dissolving tablets." Future Journal of Pharmaceuticals and Health Sciences 4, no. 2 (2024): 32–38. http://dx.doi.org/10.26452/fjphs.v4i2.599.

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The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural

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9

Gurram, Syam Sundar. "Formulation and evaluation of nifedipine fast dissolving tablets." Formulation and evaluation of nifedipine fast dissolving tablets 4, no. 2 (2025): 32–38. https://doi.org/10.5281/zenodo.14651206.

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The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural

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Sukhavasi, Sudheshnababu, and V. Sai Kishore. "Formulation and evaluation of fast dissolving tablets of amlodipine besylate by using Fenugreek seed mucilage and Ocimum basilicum gum." International Current Pharmaceutical Journal 1, no. 9 (2012): 243–49. http://dx.doi.org/10.3329/icpj.v1i9.11614.

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Fast dissolving/disintegrating tablets have received ever-increasing demand during the last decade, and the field has became a rapidly growing area in the pharmaceutical area. Particularly the fast dissolving drug delivery systems formulated with natural polymers have more demand because natural materials like gums and mucilages have been extensively used in the field of drug delivery for their easy availability, ease administration, non toxicity, non irritant nature etc. The main aim of the present study was to formulate the fast dissolving tablets of amlodipine besylate tablets using Fenugre

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Venkateswara, Rao. S* Rodhay. G. &. Padmalatha. K. "DESIGN AND EVALUATION OF MOUTH DISSOLVING TABLETS OF TELMISARTAN BY USING DIFFERENT SUPER DISINTEGRANTS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 707–23. https://doi.org/10.5281/zenodo.1036331.

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The present research was carried out to develop mouth dissolving tablets using superdisintegrants and improve the solubility ultimately bioavailability of Telmisartan by encapsulating it inside the cavity of β-cyclodextrin. Mouth dissolving tablets improve the oral bioavailability by enhancing the drug disintegration and release of drug particles from the dosage form, which enable quick and direct delivery into the circulatory system by avoiding first pass metabolism. Total nine batches of mouth dissolving tablets were prepared using superdisintegrants like Crosscarmellose sodium (CCS), Sodium

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Moghal, Md Mizanur Rahman, Sujit Chandra Mazumder, Dilshad Noor Lira, and Abu Shara Shamsur Rouf. "Fabrication and in vitro Evaluation of Allopurinol Fast Dissolving Tablets Using Croscarmellose Sodium, Sodium Starch Glycolate and Crospovidone as Superdisintegrants." Dhaka University Journal of Pharmaceutical Sciences 15, no. 1 (2016): 73–81. http://dx.doi.org/10.3329/dujps.v15i1.29199.

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The main objective of the study was to formulate fast dissolving tablets of allopurinol to achieve better dissolution rate and further improving the bioavailability to provide a quick onset of action. Nine formulations of fast dissolving tablets of allopurinol were prepared by direct compression technique using croscarmellose sodium (Group A), sodium starch glycolate (Group B) and crospovidone (Group C) as superdisintegrants in different concentrations. All formulations showed satisfactory mechanical strength, uniform weight & drug content, and lesser wetting time & dispersion time. In

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13

Rao, Y. Srinivasa, and K. Adinarayana Reddy. "Design and In vivo Evaluation of Palonosetron HCl Mouth Dissolving Films in the Management of Chemotherapy-Induced Vomiting." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 6 (2017): 3929–36. http://dx.doi.org/10.37285/ijpsn.2017.10.6.9.

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Fast dissolving oral delivery systems are solid dosage forms, which disintegrate or dissolve within 1 minute in the mouth without drinking water or chewing. Mouth dissolving film (MDF) is a better alternate to oral disintegrating tablets due to its novelty, ease of use and the consequent patient compliance. The purpose of this work was to develop mouth dissolving oral films of palonosetron HCl, an antiemetic drug especially used in the prevention and treatment of chemotherapy-induced nausea and vomiting. In the present work, the films were prepared by using solvent casting method with various

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14

Kanathe, Pooja, Ruchi Jain, Nilesh Jain, and Surendra Kumar Jain. "Formulation and Evaluation of Orodispersible Tablet of Fluvastatin Sodium." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 42–47. http://dx.doi.org/10.22270/jddt.v11i1.4498.

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The purpose of this research work is to formulate and evaluate the Orodispersible tablet of Fluvastatin Sodium to enhance the bioavailability and effectiveness of the drug. The objectives of the drug work were to formulate and evaluate Orodispersible tablets of Fluvastatin Sodium, having adequate mechanical strength, rapid disintegration, and fast action. Precompression parameters like angle of repose, bulk density, tapped density, compressibility index & post-compression parameters like wetting time, water absorption ratio, in-vitro disintegration, and in-vitro dispersion time were studie

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15

Arora, V., S. Kumar, P. B. Mishra, and N. Vashisht. "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF RANITIDINE HYDROCHLORIDE." INDIAN DRUGS 52, no. 09 (2015): 13–20. http://dx.doi.org/10.53879/id.52.09.p0013.

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In present research work, taste masked Mouth Dissolving Tablets (MDTs) of Ranitidine Hydrochloride were designed with a view to enhance the patient compliance and provide a quick onset of action. Taste masking of the drug was done by formation of complex with β cyclodextrin. Tablets were prepared by direct compression, using superdisintegrants like crosscarmellose sodium and crosspovidone in different proportion and evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. In view of the better taste palatability of such a bitter API, taste maskin

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T.AYYAPPAN, A.V.ARCHANA, B.MANOJ, and .T.AYYAPPAN Dr. "Studies on Formulation and in-Vitro Evaluation of Mouth Dissolving Tablets Containing Telmisartan by using Box-Benkhen Design." International Journal of Innovative Science and Research Technology 8, no. 2 (2023): 206–12. https://doi.org/10.5281/zenodo.7648002.

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New era is an era of novel drug delivery systems. Pediatric, Geriatric and bed ridden patients have difficulties in swallowing tablets. The purpose of the present study was to develop and characterize mouth dissolving tablets of Telmisartan by using direct compression technique. Formulations were designed by factorial design technique. Sodium Saccharine, Cross povidone and Banana powder were used as a superdisintegrants while microcrystalline cellulose was used as diluents. The powder blends were prepared and evaluated for the properties such as angle of repose, loose bulk density, tapped bulk

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Mohammed Abdelrahman1,2*, Mohamed A. M. Elhassan1, Alaa Alsadig Alzain1, et al. "Formulation and Evaluation of Quinine sulfate Dispersible Tablets with Emphasis on Taste Masking using Cyclodextrin." Omdurman Journal of Pharmaceutical Sciences 2, no. 3 (2022): 275–85. http://dx.doi.org/10.52981/ojps.v2i3.2875.

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Dispersible tablets (DTs), also termed quick dissolving, fast melting, fast dissolving, fast disintegrating and rapid dissolving tablets, are uncoated or film-coated tablets intended to be dispersed in water before administration giving a homogeneous dispersion. Conventional quinine tablets have bitter taste when broken or dispersed to allow administration for children. Cyclodextrins (CDs) are cyclic oligosaccharides whose structural feature gives a hydrophobic interior and a hydrophilic exterior are widely used to increase the solubility of poorly soluble drugs. Recent studies showed that CDs

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18

LINKU, ABRAHAM, and JOSEPH SIJIMOL. "FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF ANTI-ALLERGIC DRUG." Asian Journal of Pharmaceutical Research and Development 6, no. 3 (2018): 5–16. http://dx.doi.org/10.22270/ajprd.v6i3.374.

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The aim of present work was the development of fast dissolving oral film of Loratadine to overcome the limitations of current routes of administration, to provide immediate action and increase the patient compliance. To improve the bioavailability of the drug, fast dissolving oral film were formulated using different grades of Hydroxy Propyl Methyl Cellulose(HPMC) and various plasticizers like Polyethylene Glycol(PEG) 400, glycerol, Propylene glycol(PG) by solvent casting method. The formulated films were evaluated for film thickness, surface pH, folding endurance, weight variation, % moisture

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Alkufi, Hussein, Abdul_Ghaffar S. Alkanani, Saja H. Muhareb, Ahmed K. Alhamidawi, Mathab A. Shahad, and Sara H. Abd. "Quality Assessment of Brands and Generic in Atorvastatin Tablets Available in Iraq-thi-Qar." Journal of Medical and Health Studies 4, no. 2 (2023): 08–13. http://dx.doi.org/10.32996/jmhs.2023.4.2.2.

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Hypolipidemic agents have been shown to be helpful in the primary and secondary prevention of cardiovascular disease. Statins are frequently administered to treat hyperlipidemia. Although there are many statins on the market today, atorvastatin is the one that is most frequently recommended. The medications must meet the required physical qualities and contain the right quantity of active medicinal components. The primary goal of the study was to assess the value of several brands of atorvastatin calcium tablets sold in Iraq.Methods: In this study, the in vitro dissolving test, disintegration,

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Acharya, A., G. B. K. Kumar, P. Goudanavar, and K. Dhakal. "Various approaches to enhance the dissolution of Lornoxicam fast dissolving tablets prepared by using different categories of superdisintegrants: A comparative study." Journal of Manmohan Memorial Institute of Health Sciences 4, no. 1 (2018): 86–102. http://dx.doi.org/10.3126/jmmihs.v4i1.21147.

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Background: Recent developments in fast dissolving tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets.The main objective of the present study is to formulate fast dissolving tablet of Lornoxicam by direct compression method.Methods: Guar gum and crospovidone were used as natural and synthetic superdisintegrants respectively. Fast dissolving tablet of Lornoxicam were prepared by direct compression technique using three different approaches; superdisintegrant addition, sublimation, and solid dispersion.Results: IR and DSC studies s

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Abid, Md Ather Ahmed, and Saritha Chukka. "Formulation And Evaluation Of Rizatriptan Benzoate Mouth Dissolving Tablets Using Natural Superdisintegrants." Journal of Neonatal Surgery 14, no. 32S (2025): 3405–11. https://doi.org/10.63682/jns.v14i32s.7940.

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Introduction: Rizatriptan benzoate is a new generation anti-migraine drug, potent and selective 5-hydroxy tryptamine 1B/1D receptor agonist used for the treatment of acute migraine attack. The bioavailability of Rizatriptan benzoate is about 45%. The half-life is 2 to 3 hours. The aim of the study was to formulate Rizatriptan benzoate mouth dissolving tablets (MDT) to enhance the dissolution rate to facilitate quick onset of action. Methods: Total nine formulations were developed by direct compression method using three natural super-disintegrants. DSC was conducted to study the drug-excipient

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22

Pande, V. V., A. A. Patel, V. P. Patel, and P. V. Khedkar. "FORMULATION AND EVALUATION OF FAST DISSOLVING FILM OF FOSINOPRIL." INDIAN DRUGS 55, no. 12 (2018): 34–40. http://dx.doi.org/10.53879/id.55.12.11461.

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The mouth dissolving film overcomes the shortfalls of conventional quick dispersing/dissolving intraoral tablets. Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure.It undergoes extensive hepatic first pass metabolism, with bioavailability being only 36%. In the present investigation, an attempt was made to formulate fast dissolving film of fosinopril sodium by Solvent casting method using various film forming polymers such as HPMC 5cps, HPMC E-3, HPMC E-15 each being varied at three different concentrat

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Pervaiz, Rabia, Nida Amjad, and Hafsa Ibrar. "Fabrication and evaluation of tizanidine hydrochloride fast dissolving films." Journal of Contemporary Pharmacy 3, no. 2 (2020): 44–48. http://dx.doi.org/10.56770/jcp2019323.

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Tizanidine Hydrochloride is widely used in the treatment of multiple sclerosis spastic diplegia back pain or certaininjuries to the spine or CNS. Objective: The present work aimed at preparing quick release films of tizanidine HClwith the purpose of developing a dosage form for a very quick onset of action, which is beneficial in managingspasms and increased muscle tone, aiding in the enhancement of bioavailability, and is very convenient for administration, without the problem of swallowing and using water. Methods: The films of tizanidine hydrochloridewere prepared by using polymers such as

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SND, Chandra, Bharathi A, Suresh SBAV, and Shabana P. "Design and Evaluation of Fast Dissolving Tablets of Anti-Hypertensive Poorly Soluble Drug through 23 Factorial Designs." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 973–77. https://doi.org/10.25258/ijddt.14.4.7.

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The purpose of this study was to improve the anti-hypertensive effect of telmisartan fast-dissolving tablets by formulating them with a synthetic superdisintegrant. The effects of three factors—SH [A], SSG [B], and CCS [C] on dependent variables like the in vitro method, water absorption, and percent drug release at 10 minutes were investigated in this survey using three factors in a two-level (23) factorial design. The production of starch hyaluronate, a fine, freely-flowing crystalline powder, was accomplished by the esterification process. The ester bond between starch and hyaluronic acid w

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Nagendra, R.1 Anusha B. H.2* Venkatesh K.3 Hanumanthachar Joshi4 Tanuja A. . J.5. "Innovations in Fast Disintegrating Tablet Formulation: Harnessing the Power of Super disintegrants for Rapid Oral Dissolution." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 380–91. https://doi.org/10.5281/zenodo.10673308.

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This work looks into how to improve the oral dissolving qualities of fast disintegrating tablets (FDTs) by formulating and testing them using cutting-edge super disintegrants. Modern super disintegrants have the ability to dissolve and disintegrate quickly in FDTs, which could be advantageous for patient convenience and compliance. To maximize tablet disintegration times, a variety of super disintegrants were used, such as sodium starch glycolate, crospovidone, and croscarmellose sodium. Excipients such binders, diluents, and sweeteners were carefully chosen to ensure compatibility and maintai

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Badadhe, Sandip, Hanumant Bhusnar, Avinash Birajdar, Jayadeep Yadav, and Bhagwat Chavan. "Development and Validation of New Discriminative Dissolution Method for Dapagliflozin Tablets." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 396–404. http://dx.doi.org/10.25258/ijddt.14.1.58.

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In this study, we aimed to find out how well dapagliflozin worked by creating and testing a new way to dissolve the pills. We considered a great many factors, including the quantity of dissolved liquid, the liquid’s composition, and the rotational speed of the paddle. Apparatus II, or the paddle, was employed to get the perfect in-vitro breakdown profile. The dissolving media consisted of 900 mL of phosphate buffer with a pH of 6.8, and the machine was spun at a speed of 50 revolutions per minute. For the purpose of assessing the drug release method’s properties, high-performance liquid chroma

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Hussain, Amjad, Sidra Nasir, Fahad Hussain, et al. "Improved Dissolution Rate of Oxcarbazepine by Centrifugal Spinning: In-Vitro and In-Vivo Implications." Proceedings 78, no. 1 (2020): 7. http://dx.doi.org/10.3390/iecp2020-08702.

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Low dissolution rates of poorly soluble drugs are the factor afflicting their bioavailability. The aim of this study is to prepare a centrifugal spinning-based formulation of a poorly soluble drug, oxcarbazepine, for the improvement of dissolution rate and hence quick action. Sucrose-based microfibers of oxcarbazepine were prepared by a centrifugal melt spinning technique using a cotton candy machine. The prepared microfibers were characterized using Scanning electron microscopy (SEM), PXRD, Differential Scanning Calorimetry (DSC) and FTIR. The optimum formulation was molded into tablets and t

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Brock, Michael H., Richard J. Dansereau, and Vikram S. Patel. "Use of In Vitro and In Vivo Data in the Design, Development, and Quality Control of Sustained‐Release Decongestant Dosage Forms." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 14, no. 4 (1994): 430–37. http://dx.doi.org/10.1002/j.1875-9114.1994.tb02833.x.

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Study Objectives. To investigate the use of in vitro and in vivo data in the development of a sustained‐release, carbomer‐based dosage form (Entex LA tablets); and to compare the in vitro dissolution of pseudoephedrine from a sustained‐release, hydroxypropylcellulose‐based dosage form (Entex PSE tablets) and four branded competitors with different sustained‐release matrixes.Design. Entex LA: In vitro testing by rotating bottle method and in vivo testing as double‐blind, randomized, crossover, 24‐hour study. Entex PSE and four competitors: in vitro testing by paddle method.Setting. A pharmaceut

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Bolmal, Uday, C. K. Pandey, V. Phatarpekar, N. G. Dhople, and Rajkumar Kotha. "Comparative Evaluation of Isoniazid and Rifampicin Dispersible Tablets Prepared by Direct Compression and Sublimation Methods." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 4 (2013): 2225–39. http://dx.doi.org/10.37285/ijpsn.2013.6.4.5.

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Dispersible tablets are gaining popularity over conventional tablets due to its increased popularity for administration to pediatric and geriatric patients as it provides quick onset of action and ease of administration. An attempt had been made, to develop dispersible tablet of isoniazid and rifampicin combination by direct compression and sublimation method, to increase the bioavailability of the anti-tubercular agents as well to provide the local delivery in the case of oral tuberculosis. Formulation F1 to F8 (2% and 4% w/w of different superdisintegrants (crospovidone, pregelatinized starc

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Shukla, Kavita Varma, Ankita Rai, and Rekha Pathak. "Formulation Development and Evaluation of Taste Masked Oral Disintegrating Films of Atenolol by Using Natural Polymers." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 711–14. http://dx.doi.org/10.22270/jddt.v9i3-s.2961.

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Fast dissolving/disintegrating films/tablets have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical area. Particularly the fast dissolving drug delivery systems formulated with natural polymers have more demand because natural materials like gums and mucilages have been extensively used in the field of drug delivery for their easy availability, ease administration, non toxicity, non irritant nature etc. Atenolol is β1-selective adrenergic blocking agent and widely used in the treatment of hypertension and angina pector

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Gorde, V. D., Punit R. Rachh, Someshwar Mankar, Saurin Amin, and Prasad L. Gorde. "Formulation and development of bilayer tablet containing irbesartan and metformin hydrochloride for diabetic hypertensive patients." Journal of Applied Pharmaceutical Research 12, no. 4 (2024): 66–74. http://dx.doi.org/10.69857/joapr.v12i4.589.

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Background: Hypertension is a common complication of type II diabetes. The present research work aimed to develop bilayer tablets that would manage type II diabetes patients with hypertension. The prepared bilayer tablet has an immediate-release layer of anti-hypertensive irbesartan and a sustained-release (SR) layer of anti-diabetic metformin hydrochloride. The purpose of these bilayer tablets was to increase patient compliance by converting two separate monotherapy to single combination therapy. Methodology: Several ratios of polymers, including HPMC K100M, EC, Eudragit, and Guar gum, were e

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Asmaa Abdelaziz Mohamed, Firas Aziz Rahi, Amna F. Alberqdar, and Teeba Abdellatif Aziz. "In vitro Assessment of the Adsorption Efficacy of Activated Charcoal versus Kaolin on some used Medications of Narrow Index of Safety." Iraqi Journal of Pharmaceutical Sciences 33, no. 4 (2024): 96–101. https://doi.org/10.31351/vol33iss4pp96-101.

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The purpose of this study is to investigate the in vitro adsorption power of activated charcoal (AC), light kaolin (LK), and heavy kaolin (HK) at a concentration of 0.2% weight-per-volume (w/v) on high dosages (10 tablets) of a variety of medications that have a narrow safety index. This will be done by testing the adsorption capacity of the three types of kaolin at the same concentration. This list includes a variety of drugs, some of which are as follows: diazepam, metoclopramide, theophylline, digoxin, and diltiazem HCL. The test was done by dissolving the pharmaceuticals from their tablets

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Abou-Taleb, Heba A., Wesam W. Mustafa, Tarek Saad Makram, Lamiaa N. Abdelaty, Hesham Salem, and Hamdy Abdelkader. "Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability." Pharmaceutics 14, no. 3 (2022): 517. http://dx.doi.org/10.3390/pharmaceutics14030517.

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Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult-to-treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast-dissolving films (vardenafil ODFs) in the mouth without the need for water

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Aishwarya, S., Debolina Bishayi, Vinod Rakesh Jathanna, et al. "Evaluation of pH, free available chlorine and tissue dissolution property of solid dosage chlorine releasing agents for root canal irrigation based on contact time – An in vitro study." Endodontology 37, no. 2 (2025): 217–21. https://doi.org/10.4103/endo.endo_114_24.

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Aim: The aim of the study was to evaluate the pH, free available chlorine (FAC), and tissue dissolution property of various chlorine-releasing solutions prepared from predosed tablets based on the period since the preparation of the solution. Methods: Groups 1–3 are the study solutions prepared by dissolving 2.5 g of the chemical in powder form in 100 mL distilled water to obtain a 2.5% solution. The control solution is the commercially available 2.5% sodium hypochlorite (NaOCl) solution. The solutions were freshly prepared and used immediately before testing each aspect of the study. (1) Grou

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Choudhary, Nilesh, and Jasmine Avari. "Formulation and evaluation of taste mask pellets of granisetron hydrochloride as oro dispersible tablet." Brazilian Journal of Pharmaceutical Sciences 51, no. 3 (2015): 569–78. http://dx.doi.org/10.1590/s1984-82502015000300009.

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Orally disintegrating systems have carved a niche amongst the oral drug delivery systems due to the highest compliance of the patients, especially the geriatrics and pediatrics. In addition, patients suffering from dysphagia, motion sickness, repeated emesis and mental disorders prefer these medications because they cannot swallow large quantity of water. Further, drugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated in these dosage forms. However, the requirements of formulating these dosage forms with m

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Garg, Anshika, and Muskan Rathor. "Tablet Evolution: Exploring Cutting-edge Technologies in Formulation and Development." Asian Journal of Pharmacy and Technology, December 21, 2024, 373–78. https://doi.org/10.52711/2231-5713.2024.00059.

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Pharmaceutical sciences contain a wide number of territories including drug disclosure, plan improvement, testing, wellbeing and regulatory affairs. In this period of development and progression, in drug conveyance for better clinical impacts regular dosage forms have still a solid hold and are generally well known taking all things together sorts of medicinal preparation for oral use. In the last several years, the writing in drug advancement has been expanded in an amazing way. There is a consistent improvement of the assortment of details which are planned by the patient consistency, actual

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Patel, Jayendrakumar, Shalin Parikh, and Shwetaben Patel. "Fabrication And In-Vitro Analysis Of Mouth Dissolving Tablets Of Ondansetron Using Water Insoluble Super Disintegrant." Journal of Pharmaceutical Sciences and Medicinal Research 001, no. 01 (2021). http://dx.doi.org/10.53049/tjopam.2021.v001i01.003.

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In the present time, a mouth dissolving tablets become popular over conventional oral solid dosage form as it overcome common problem associated with conventional oral tablet dosage form such as issue in swallowing tablets in paediatric as well as geriatric population as well as avoid first pass metabolism and provide quick onset of action as it starts to absorb directly from oral cavity. Ondansetron HCl is used to prevent nausea and vomiting. In case of vomiting as well as in nausea, drug must require to act quickly to treat therapeutic condition of patient in need thereof. Therefore, combini

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Madhavi V. Lichade, Mohd. Vaqqas, Mohit Tembhekar, Abhishek Zade, Rahul Lichade, and Tanmay Choudhari. "Formulation and Evaluation of Fast Dissolving Tablet of Aspirin." International Journal of Advanced Research in Science, Communication and Technology, February 11, 2025, 414–20. https://doi.org/10.48175/ijarsct-23255.

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The purpose of this study was to develop and assess aspirin fast-dissolving tablets (FDT) in order to improve patient adherence, particularly for those who have trouble swallowing. Although aspirin is frequently used as an analgesic, antipyretic, and anti-inflammatory medication, some patient groups may not benefit from its standard dosage form. Several excipients, including binders (like hydroxypropyl methylcellulose) and super disintegrants (such sodium starch glycolate and croscarmellose sodium), were used in the formulation of the fast-dissolving tablets. The tablets were made using the di

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Bhatia, Vishal, Ashwani K. Dhingra, Rameshwar Dass, Bhawna Chopra, and Kumar Guarve. "Formulation Development and in-vitro Evaluation of Escitalopram Fast Dissolving Tablets." Central Nervous System Agents in Medicinal Chemistry 22 (June 24, 2022). http://dx.doi.org/10.2174/1871524922666220624113719.

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Background: Escitalopram, a selective serotonin reuptake inhibitor (SSRI), acts by increasing the serotonin level in the brain and is used widely for the management of depression and anxiety disorders. However, the poor dissolution rate of escitalopram due to less water solubility is a consequential problem confronting the pharmaceutical industry in developing pharmaceutical dosage forms for oral delivery systems. Objective: The present work aims to deliver a novel formulation for improving the dissolution profile and, thus, the bioavailability of escitalopram. Methods: Fast Dissolving Tablets

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Neha, Fathima* Dr. Jyothi P. Dr. R. Hemalatha. "FORMULATION AND EVALUATION OF CONTROLLED RELEASE OF ASPIRIN TABLET USING DIRECT COMPRESSION METHOD." November 2, 2022. https://doi.org/10.5281/zenodo.7274242.

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<em>The coordinate compression approach, which has been around for a long time, benefits quickly dissolving definitions significantly. Furthermore, various concentrations of the super disintegrant were used to provide the most bioavailable information possible. In definitions with a predominant super disintegrant, in vitro crumbling time and disintegration will be accelerated, while friability and weight change will be reduced. When super disintegrants are used to create a fast-dissolving tablet, it is faster and releases the pharmaceutical sooner than a conventionally developed tablet. A cumu

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Venkateswara, Rao. S* Rodhay. G. &. Padmalatha. K. "DESIGN AND EVALUATION OF MOUTH DISSOLVING TABLETS OF TELMISARTAN BY USING DIFFERENT SUPER DISINTEGRANTS." September 30, 2017. https://doi.org/10.5281/zenodo.2526853.

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The present research was carried out to develop mouth dissolving tablets using superdisintegrants and improve the solubility ultimately bioavailability of Telmisartan by encapsulating it inside the cavity of β-cyclodextrin. Mouth dissolving tablets improve the oral bioavailability by enhancing the drug disintegration and release of drug particles from the dosage form, which enable quick and direct delivery into the circulatory system by avoiding first pass metabolism. Total nine batches of mouth dissolving tablets were prepared using superdisintegrants like Crosscarmellose sodium (CCS), S

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Yadav, Akash. "Complication and Assessment of Time Sensitive Tablets Involving Design Expert Software." Journal of Diabetes Research Reviews & Reports, February 28, 2025, 1–11. https://doi.org/10.47363/jdrr/2025(7)200.

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This research investigated the creation of fast-dissolving tablets containing glipizide, utilizing a Box-Behnken design and direct compression method. The study aimed to incorporate natural super disintegrants such as Plantago ovata seed mucilage and the natural binder Guar gum, in addition to the synthetic super disintegrant cross-povidone. Detailed pre-formulation studies were carried out to verify the compatibility between glipizide and all the excipients used in the formulation. The resulting fast-dissolving tablets were thoroughly assessed for weight variation, hardness, friability, disin

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PRAKASH RAO, A. HARI OM, SANTOSH KUMAR RADA, and SHAMBHAVI KANDUKURI. "OPTIMIZATION OF STARCH CROTONATE AS A NOVEL SUPERDISINTEGRANT IN THE FORMULATION OF FAST DISSOLVING TABLETS THROUGH 23 FACTORIAL DESIGN." International Journal of Applied Pharmaceutics, July 7, 2021, 247–56. http://dx.doi.org/10.22159/ijap.2021v13i4.41335.

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Objective: To synthesize, characterize and evaluate starch crotonate as a superdisintegrant in the formulation of Piroxicam fast dissolving tablets by employing 23 factorial design. Methods: Starch crotonate was synthesized and its physical and micromeritic properties were performed to evaluate it. The fast dissolving tablet of Piroxicam were prepared by employing starch crotonate as a superdisintegrant in different proportions in each case by direct compression method using 23 factorial design. Results: The starch chrotonate prepared was found to be fine, free flowing and amorphou

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SANTOSH KUMAR R and SAHITHI MUDILI. "FORMULATION AND EVALUATION OF STATISTICALLY DESIGNED IBUPROFEN FASTDISSOLVING TABLETS EMPLOYING STARCH GLUTAMATE AS A NOVEL SUPERDISINTEGRANT." Asian Journal of Pharmaceutical and Clinical Research, September 16, 2019, 85–94. http://dx.doi.org/10.22159/ajpcr.2019.v12i11.35308.

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Objective: The main aim of the present work is to enhance the solubility and bioavailability of the ibuprofen by formulating it into fast-dissolving tablets employing starch glutamate as a novel superdisintegrant. Materials and Methods: Starch glutamate was prepared from native potato starch and glutamic acid by the esterification process. Drug-excipient compatibility studies were performed between the starch glutamate and ibuprofen with the help of Fourier transform infrared spectroscopy, and differential scanning calorimetry techniques. Ibuprofen fast dissolving tablets were formulated

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SANTOSH KUMAR, R., SHAMBHAVI KANDUKURI, M. RAMYA, and B. KUSUMA LATHA. "DESIGN, OPTIMIZATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS EMPLOYING STARCH VALERATE–A NOVEL SUPERDISINTEGRANT." International Journal of Applied Pharmaceutics, July 7, 2021, 168–76. http://dx.doi.org/10.22159/ijap.2021v13i4.41122.

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Objective: To synthesize, characterize and evaluate starch valerate as a superdisintegrant in the formulation of aceclofenac fast dissolving tablets by employing 23 factorial design. Methods: Starch valerate was synthesized and its physical and micromeritic properties were performed to evaluate it. The fast dissolving tablet of aceclofenac was prepared by employing starch valerate as a superdisintegrant in different proportions in each case by direct compression method using 23 factorial design for evaluation of tablet parameters like disintegration and dissolution efficiency in 5 min.&#

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S*, Kiran, Khemchand S, Shivraj J, and Dhananjay P. "Comprehensive Study on Pharmaceutical Delivery: Mouth Dissolving Tablets." Open Access Journal of Pharmaceutical Research 8, no. 3 (2024). http://dx.doi.org/10.23880/oajpr-16000319.

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Fast-disintegrating tablets are one of the most often utilized dose forms available, particularly for youngsters whose nervous and muscular systems are still developing in comparison to adults. in grownups. and in adult individuals who have hand tremors or Parkinson's disease. Due to swallowing difficulties caused by dysphagia, many fixed dose forms, including tablets and capsules, no longer comply with prescribed dosages, making therapy ineffective. Oral dosage forms and the oral route with certain constraints, such as first-pass liver metabolism, mental patients, at-risk patients, and non-co

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TORGAL, TEJASVI, SHWETA BORKAR, PRASHANT BHIDE, and ASMITA ARONDEKAR. "FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING FILMS OF EBASTINE." International Journal of Current Pharmaceutical Research, September 17, 2020, 111–15. http://dx.doi.org/10.22159/ijcpr.2020v12i5.39782.

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Objective: To overcome the limitations of fast dissolving tablets, a novel fast dissolving film of ebastine was formulated for attaining quick onset of action, aiding in the enhancement of bioavailability favorable in severe conditions of allergies. Methods: Films of ebastine were prepared by the solvent casting method using hydroxypropyl methylcellulose E-15, hydroxypropyl methylcellulose K-4 as a film base with different concentrations of crospovidone as superdisintegrant and polyethylene glycol-400 as a plasticizer. Further physical characteristics such as uniformity of weight, thickn

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Singh, Sakshi, and Arpna Indurkhya. "Formulation and Evaluation of Fast Dissolving Tablets of Atorvastatin Calcium using Starch Malonate." International Journal of Newgen Research in Pharmacy & Healthcare, June 30, 2024, 122–28. http://dx.doi.org/10.61554/ijnrph.v2i1.2024.90.

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Fast dissolving tablets containing Atorvastatin calcium were prepared using the direct compression method with various superdisintegrants and evaluated for hardness, friability, weight variation, disintegration time, wetting time, and in vitro drug release. The precompression characteristics indicated good flow properties and compressibility of the drug with the excipients. Post-compression evaluations showed uniform hardness, thickness, and diameter across all tablets, ensuring uniform size, shape, and good resistance to mechanical damage. The weight variation of all formulations was within p

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Patil, Swapnil Shankar, and Shashikant Sudarshan Upadhye. "Formulation and Assessment of Quick dissolving tablet of Candesartan cilexetil arranged from their circular agglomerates." Research Journal of Pharmacy and Technology, February 26, 2022, 853–58. http://dx.doi.org/10.52711/0974-360x.2022.00142.

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Candesartan cilexetil is water insoluble drug which comes under BCS class second category. Drug was used in the treatment of acute and chronic hypertension. The research workgenerally focuses on the solubility enhancement, increasing dissolution behavior, flowability and compressibility of the drug. Tablets and capsule are the solid dosage form mostly used. Spherical agglomerates of Candesartan cilexetil were prepared. Candesartan cilexetil water insoluble drug was used. With the incorporation of polymer, Agglomerates of such drug was prepared. Fast dissolving tablet was prepared and evaluated

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Rao N G, Raghavendra, Priyanka Gupta, and Sheela M A. "Trigonella foenum-Plantago Ovata Seeds Mucilage as a Superdisintegrants for the Development of Bisoprolol Fumarate Loaded Quick Dissolving Tablet (QDT)." Research Journal of Pharmacy and Technology, January 27, 2023, 23–30. http://dx.doi.org/10.52711/0974-360x.2023.00005.

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Objective: The aim of this present research work, the aim was to develop drug-loaded Bisoprolol fumarate quick-dissolving tablets by direct compression method by using Trigonella Foenum - Plantago ovata seeds mucilage. Comparative studies between synthetic and natural superdisintegrants. Bisoprolol Fumarate is an antihypertensive drug incorporated in handling hypertension, and as a prophylaxis treatment of angina pectoris, heart failure. Methods: Bisoprolol fumarate-loaded tablets were developed, estimated for different pre and post-compressional parameters, FTIR study, and short-term stabilit

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