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Dissertations / Theses on the topic 'In Vitro Type Drug Release'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

SMITH, DENISE ANNE BUSH. "In vitro Characterization of Echogenic Liposomes (ELIP) for Ultrasonic Delivery of Recombinant Tissue-type Plasminogen Activator (rt-PA)." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1214234148.

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2

Graham, M. "Studies on the in-vitro release of salicyclic acid from a polyethylene mineral oil gel." Thesis, De Montfort University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354361.

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3

Quigley, Karen Josephine. "Factors influencing formation and the in vitro drug release from pellets containing chitosan." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266848.

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4

Tettey-Amlalo, Ralph Nii Okai. "In vitro release of ketoprofen from proprietary and extemporaneously manufactured gels." Thesis, Rhodes University, 2005. http://eprints.ru.ac.za/295/.

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5

Wang, Hezhong. "Chitosan-Cellulose Nanocrystal Polyelectrolyte Complex Particles: Preparation, Characterization, and In Vitro Drug Release Properties." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/40353.

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Polyelectrolyte complexes (PECs) between chitosan, a mucoadhesive, intestinal mucosal permeability-enhancing polysaccharide, and cellulose nanocrystals, rod-like cellulose nanoparticles with sulfate groups on their surface, have potential applications in oral drug delivery. The purpose of this research was to develop an understanding of the formation and properties of chitosan–cellulose nanocrystal PECs and determine their in vitro drug release properties, using caffeine and ibuprofen as model drugs. Cellulose nanocrystals were prepared by sulfuric acid hydrolysis of bleached wood pulp. Chitos

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6

Iyer, Sunil S. "A 'Biorelevant' Approach for Accelerated In Vitro Release and In Vitro-In Vivo Relationship of a Biodegradable, Naltrexone Implant." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1523.

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7

Ur-Rehman, Tofeeq. "Controlled release gel formulations and preclinical screening of drug candidates." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40489.

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Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. In particular co-solvents (DMSO, ethanol), mucoadhesive polymers (chitosan, alginate) and salts (sodium tripolyphosphate, CaCl2) have been used to enhance the applications of poloxamer 407 (P407) formulations in preclinical animal studies. The impact of these additives on the micellization and

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8

Chinnakavanam, Sundararaj Sharath Kumar. "Development of a Multilayered Association Polymer System for Sequential Drug Delivery." UKnowledge, 2013. http://uknowledge.uky.edu/cbme_etds/13.

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As all the physiological processes in our body are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the primary objective of this research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. This particular device was designed aimed at the treatment of periodontitis, a highly prevalent oral inflammatory disease that affects 90% of the world population. This condition is caused by bacterial biofilm on the teeth, resulting in

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9

ZHOU, YING. "DETERMINATION OF in vitro DRUG RELEASE FROM WOUND DRESSINGS THROUGH AN ARTIFICAL WOUND MODEL." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1018614820.

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10

Ei, Ei Maw Varaporn Junyaprasert. "Effects of different oil types and surfactant concentrations on the physical stability of nanoemulsions and In Vitro release of Diclofenac-loaded nanoemulsions /." Abstract, 2007. http://mulinet3.li.mahidol.ac.th/thesis/2550/cd406/4837397.pdf.

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11

Goldoozian, Seyedreza [Verfasser]. "In vitro-in vivo correlation and modelling of drug release for HPMC-based matrix tablets / Seyedreza Goldoozian." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1151881279/34.

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12

Mu, Xiaohong. "In vitro characterisation of food effects on in vivo performance of a heterodisperse polysaccharide-based controlled drug delivery system in gastrointestinal tract." Thesis, University of Bath, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340927.

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13

Fang, Yuan Yuan. "In vitro drug-herb interaction potential of African medicinal plant products used by Type II diabetics." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1341.

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In Africa, use of medicinal plants for the treatment of diabetes is very common. However, efficacy on co-administering of medicinal plants with therapeutic drugs hasn't been fully determined, especially for African medicinal plants. The current study focused on assessing the in vitro modulation effects of three popular African medicinal plants, namely: Aloe ferox, Sutherlandia frutescens and Prunus africana (including five commercial preparations containing these medicinal plants) on two of the most important anti-diabetic drug metabolising enzymes, Cytochrome P450 (CYP450) 2C9 and CYP3A4 and

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14

Schader, Susan. "The evaluation of candidate microbicide antiretrovirals against wild type and drug resistant HIV-1 «in vitro»." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107740.

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Over the last 30 years, the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) mêlée has endured despite valiant efforts made by the research community. Although great strides in treatment efficacy have been made, an effective vaccine remains beyond our reach. Anti- HIV microbicides, (topically applied agents to prevent the transmission of HIV), offer an infection prevention strategy that may buy us time until an effective vaccine is discovered. Indeed, antiretroviral (ARV)-based microbicides have proven more effective than any vaccine clinical trial to date. Improved

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15

Booysen, Laetitia Lucretia Ismarelda Josephine. "The in vitro and in vivo pharmacokinetic parameters of polylactic-co-glycolic acid nanoparticles encapsulating anti-tuberculosis drugs / L.L.I.J. Booysen." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9106.

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Tuberculosis (TB) is an infectious, deadly disease, caused by Mycobacterium tuberculosis (M.tb). In 2010, there were 8,8 million incident cases of TB globally. South Africa currently has the third highest TB incident cases worldwide. In an attempt to address the challenges facing TB chemotherapy, among which frequent dosing and long duration of therapy resulting in poor patient compliance, a novel poly(DL-lactic-co-glycolic) acid (PLGA) nanoparticulate drug delivery system (DDS) encapsulating anti-TB drugs was developed. It is hypothesised that this nanoparticulate DDS will address the challen

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16

Togami, Hiroaki. "Comprehensive in vitro susceptibility analysis of simian retrovirus type 4 to antiretroviral agents." Kyoto University, 2013. http://hdl.handle.net/2433/179351.

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17

Nayak, Atul. "Microneedle assisted percutaneous delivery of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/21705.

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Local anaesthetic drugs are usually administered as symptom relieving drug formulations for the treatment of pain in superficial skin extremities. The anaesthesia is delivered into skin tissues at the site of pain because of nociceptive receptors. Concerns that exist regarding local anaesthetic drug formulations are low drug encapsulation efficiency, polydispersity of colloidal formulations, chemical interactions of released local anaesthetic drug with skin proteins and bulk viscoelastic properties. Complimenting drug formulation characteristics are the desirable rates of controlled release of

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18

BISWAS, DEBLINA. "A BIORELEVANT IN VITRO MODEL TO CHARACTERIZE IN VIVO RELEASE OF BONE MORPHOGENETIC PROTEIN-2 (rhBMP-2)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4977.

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Biorelevant in vitro release/dissolution tests are designed to predict the in vivo behavior of a drug and are crucial in understanding its in vivo performance. Currently, there is no standardized compendial in vitro release testing methods or regulatory guidance’s for release/dissolution testing of implants due to their complex physiological locations.Furthermore, existing compendial methods do not capture the local release profile of ‘novel’ parenterals in physiological low fluid volume surrounding areas. Long acting and in situ forming implants with orthobiologic proteins and peptides have i

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19

Maccari, Flavia Lima Ribeiro [UNESP]. "Avaliação da atividade antiproliferativa in vitro, liberação, permeação e retenção cutânea in vitro e estabilidade de emulsões contendo (-)- Terpinen-4-OL." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/96248.

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Made available in DSpace on 2014-06-11T19:28:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-04-08Bitstream added on 2014-06-13T18:57:11Z : No. of bitstreams: 1 maccari_flr_me_arafcf.pdf: 1400540 bytes, checksum: 7bc406a11537837c7f75cdf60b68c782 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Universidade Estadual Paulista (UNESP)<br>O terpinen-4-ol é o principal componente da M. alternifólia, apresenta atividade antiinflamatória, antibacteriana e antifúngica; em estudos recentes in vitro a atividade antineoplásica para linhagens celulares de melanom

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Maccari, Flavia Lima Ribeiro. "Avaliação da atividade antiproliferativa in vitro, liberação, permeação e retenção cutânea in vitro e estabilidade de emulsões contendo (-)- Terpinen-4-OL /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/96248.

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Resumo: O terpinen-4-ol é o principal componente da M. alternifólia, apresenta atividade antiinflamatória, antibacteriana e antifúngica; em estudos recentes in vitro a atividade antineoplásica para linhagens celulares de melanoma (M14) foi demonstrada. O objetivo específico deste trabalho foi verificar a atividade farmacológica in vitro dos isômeros óticos (-) terpinen-4-ol e (+) terpinen-4-ol e do óleo de Melaleuca alternifolia em nove linhagens diferentes de células tumorais, incluindo a célula UACC-62 do melanoma que ainda não havia sido estudada, e a concentração eficaz para o desenvolvime

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21

Hofsäss, Martin Andy [Verfasser], Jennifer [Akademischer Betreuer] Dressman, Jennifer [Gutachter] Dressman, and Werner [Gutachter] Weitschies. "In vitro release testing as an alternative to establishing bioequivalence of drug products in vivo / Martin Andy Hofsäss ; Gutachter: Jennifer Dressman, Werner Weitschies ; Betreuer: Jennifer Dressman." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://d-nb.info/1229989269/34.

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22

Reeff, Jonathan. "Development and evaluation in vitro and in vivo of injectable hydrolipidic gels with sustained-release properties for the management of articular pathologies." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209288.

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Future changes in the incidence and prevalence of OA are difficult to predict. As incidence and prevalence rise with increasing age, extending life expectancy will result in greater numbers with OA. Actually, usual therapeutic approaches are really restricted because of important side effects with long-term use. Therefore, there is a need to develop improved formulations which are well tolerated, biocompatible and biodegradable. Ideally, these new treatments should be able to deliver locally sufficient amount of anti-inflammatory or analgesic drugs into the site of arthritic inflammation while

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23

Arai, Daisuke. "Development of a stent capable of the controlled release of basic fibroblast growth factor and argatroban to treat cerebral aneurysms : In vitro experiment and evaluation in a rabbit aneurysm model." Kyoto University, 2019. http://hdl.handle.net/2433/244518.

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24

Andrade, Diego Fontana de. "Nanocápsulas de núcleo lipídico : estudos de penetração cutânea e proposição de estratégias para a avaliação da liberação in vitro." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/94616.

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Neste trabalho foi avaliada a permeação/penetração cutânea in vitro (pele suína) de propionato de clobetasol nanoencapsulado incorporado em um semissólido, empregando células de difusão de Franz. A nanoencapsulação foi capaz de reduzir a quantidade de fármaco que penetra nas camadas da pele (estrato córneo, epiderme e derme) sem alterar a forma (distribuição percentual) como o propionato de clobetasol se distribui. A adequabilidade de diferentes membranas sintéticas (acetato de celulose, policarbonato e membrana de diálise) para a avaliação da liberação in vitro, empregando células de difusão

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25

Youssef, Ahmed M. M. "Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/13982.

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Youssef, Ahmed Mohamed Mohamed. "Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs : in vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/13982.

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Matrix metalloproteinases (MMPs) play a significant role in degrading the extracellular matrix in cancer development and metastasis. Overexpression of matrix metalloproteinases in tumour tissues relative to normal tissues has been exploited as a target for peptide-based therapeutics, to improve therapeutic index of currently used agents. The stability of MMP-activated prodrugs in normal tissue or organs is a significant challenge for their success in the clinic. In an in vitro study, the stability of twenty six prodrugs was studied in mouse liver, kidney, lung and tumour homogenates using HPLC

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27

Ménard, Mathilde. "Synthèse de nanoparticules hybrides de type coeur-coquille à visées théranostiques." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAE050/document.

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Le but de ce travail de thèse a été de synthétiser de nouveaux nano-objets pour le diagnostic et le traitement du cancer. Ainsi, nous avons développé des nanoparticules hybrides constituées d'un noyau inorganique recouvert d'une couche organique de sérum albumine humaine (HSA). Le noyau inorganique est un composite constitué d'un cœur d'oxyde de fer (IO) et d'une coquille de silice mésoporeuse (MS). L’IO permet, grâce à ses propriétés magnétiques, le diagnostic par imagerie par résonance magnétique (IRM) et la thérapie par hyperthermie magnétique (HM), tandis que les porosités de la MS permett

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28

Li, Xiaojian. "MULTI-COMPONENT MICROPARTICULATE/NANOPARTICULATE DRY POWDER INHALATION AEROSOLS FOR TARGETED PULMONARY DELIVERY." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/31.

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The aim of the work was to design, manufacture, and characterize targeted multi-component dry powder aerosols of (non-destructive) mucolytic agent (mannitol), antimicrobial drug (tobramycin or azithromycin), and lung surfactant mimic phospholipids (DPPC:DPPG=4:1 in molar ratio). The targeted dry powder for inhalation formulation for deep lung delivery with a built-in rationale of specifically interfering several disease factors of chronic infection diseases in deep lungs such as cystic fibrosis, pneumonia, chronic bronchitis, and etc. The dry powder aerosols consisting of selected chemical age

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Agossa, Kevimy. "Implants formés in-situ pour le traitement des poches parodontales : évaluation in-vitro et in-vivo." Thesis, Lille 2, 2018. http://www.theses.fr/2018LIL2S037/document.

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La frequence elevee et les consequences considerables des maladies parodontales sur la qualite de vie orale et la sante generale font de ces pathologies une preoccupation de sante publique. Le developpement de traitements innovants est un moteur essentiel du progres dans la prise en charge de ces maladies. Ce travail s’interesse a l’utilisation d’agents antimicrobiens (non-antibiotiques) et anti-inflammatoires comme adjuvants au debridement mecanique des poches parodontales. Il est consacre a la mise au point et a l’optimisation d’une forme galenique appelee implant forme in-situ (IFIS), a bas

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30

Yao, Xi. "Un modèle en 3D d’adipocytes de type brun dérivés de cellules pluripotentes induites humaines pour le criblage in vitro de médicaments et pour la thérapie cellulaire contre l’obésité." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://theses.univ-cotedazur.fr/2019AZUR6011.

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L'obésité est la conséquence d'un déséquilibre entre l'apport de calories et la dépense énergétique. Les thérapies basées sur la réduction de l'apport énergétique sont difficiles à suivre dans notre vie moderne et les médicaments anti obésité présentent d’importants effets secondaires. Des stratégies alternatives sont alors requises pour lutter contre l'obésité et les troubles métaboliques associés comme le diabète de type 2 et les maladies cardiovasculaires. Les adipocytes bruns et de type brun, encore appelés beige ou brite (BA), stockent la graisse, mais contrairement aux adipocytes blancs,

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31

Alves, Michele Campos. "Desenvolvimento e validação de métodos analíticos para o controle de qualidade de formas farmacêuticas contendo chá verde (Camellia sinensis) e estudos de liberação e permeação cutânea." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/5715.

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Jacob, Dolly. "Investigation into reliability and performance of an implantable closed-loop insulin delivery device." Thesis, De Montfort University, 2014. http://hdl.handle.net/2086/11126.

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An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied for future clinical use. Investigations into the device material compatibility with insulin solution, assessed by monitoring insulin loss and degradant formation over a period of 31 days using RP-HPLC have shown that stainless steel and titanium are the most compatible materials. Polycarbonate contribu

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HUNG-HSIN, HSU, and 許宏心. "In Vitro Drug Release from Electric-Field Responsive Polycaprolactone Nanoparticles." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/4zub9t.

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碩士<br>國立臺灣科技大學<br>材料科學與工程系<br>107<br>In this study, we prepared a biocompatible drug carrier model with electric-field response. First, we modified polycaprolactone diol’s terminal functional group to polycaprolactone diacrylate(PCLDA), which has been comfirmed by IR and NMR spectrum. Second, we used emulsion polymerization to synthesize the polycaprolactone nanoparticles with PCLDA and also labled with nile red via drug encapsulation. Using Zeta-sizer and DLS to explore particle size and potential changes under different concentration of SDS.Furthermore, a high loading efficiency 71% and high

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LungLi, Chan, and 李展榮. "In vitro and in vivo release of dinalbuphine sebacate extended release formulation: Effect of the oil ratio on drug release." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/h29q2a.

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Yang, S., X. Yin, C. Wang, et al. "Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile." 2014. http://hdl.handle.net/10454/10557.

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No<br>Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron radiation X-ray computed microtomography (SR-muCT) and a sensitive LC/MS/MS method. The purpose of this article is to introduce a powerful, non-invasive and quantitative technique for studying individual pellet microstructures and to investigate the relationship between the microstructure and drug release from

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Profeta, Martina. "Smart design and in vitro testing of nanoparticles for microenvironmentally-triggered extracellular drug release." Tesi di dottorato, 2017. http://www.fedoa.unina.it/12165/1/PhDThesisMartinaProfeta.pdf.

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In the field of nanotechnology, one of the most operative research areas is nanomedicine, which applies nanotechnology to highly specific medical interventions for the prevention, diagnosis and treatment of diseases. Currently, the major issue that nanomedicine needs to face is the smart design and production of nanoparticles (NPs) based drug delivery systems for cancer therapy. Highly efficient drug delivery based on nanoparticles could potentially reduce the drug dose needed to achieve therapeutic benefit, thus reducing the side effects associated with the systemic delivery of drugs, whit gr

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Smith, E. W., and J. M. Haigh. "In vitro systems for the assessment of drug release from topical formulations and trans-membrane permeation." 1989. http://hdl.handle.net/10962/d1006628.

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Numerous experimental methods have been developed to investigate drug release from vehicles and the percutaneous absorption of topically applied chemicals. The objective of this research is often to find correlation between laboratory results and the transdermal absorption experienced by living subjects so that in vivo experimentation may be curtailed. In many instances, the diverse experimental techniques tend to obscure absorption-controlling factors and complicate inter study comparisons, rather than clarify the complex transdermal absorption process. Moreover, lack of agreement between res

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Domingues, Nabais Maria Teresa. "High-amylose carboxymethyl starch matrices for oral sustained drug-release : in vitro and in vivo evaluation." Thèse, 2013. http://hdl.handle.net/1866/10943.

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Les amidons non modifiées et modifiés représentent un groupe d’excipients biodégradables et abondants particulièrement intéressant. Ils ont été largement utilisés en tant qu’excipients à des fins diverses dans des formulations de comprimés, tels que liants et/ou agents de délitement. Le carboxyméthylamidon sodique à haute teneur en amylose atomisé (SD HASCA) a été récemment proposé comme un excipient hydrophile à libération prolongée innovant dans les formes posologiques orales solides. Le carboxyméthylamidon sodique à haute teneur en amylose amorphe (HASCA) a d'abord été produit par l'éthérif

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Ahmed, Gamal [Verfasser]. "Effect of drug physicochemical properties on the release from liposomal systems in vitro and in vivo / Gamal Ahmed." 2009. http://d-nb.info/993152082/34.

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Silva, Rita Afonso Gomes Sobral da. "Simulation of restricted swelling and its influence on drug release in PLGA formulations for in vitro test development." Master's thesis, 2014. http://hdl.handle.net/10451/39274.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>The design of alternative strategies to deliver drugs has gained increasing attention in the past decades. When it comes to the parenteral administration route, one can state that this is the most effective form of delivery for active drug substances, especially when their bioavailability is limited by an extensive first pass metabolism effect or with a narrow therapeutic index (Goel 2014). The development of parenteral controlled release systems has been mainly based on the in

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Ahmed, Iman Saad. "In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system." Thesis, 2002. http://hdl.handle.net/1957/30202.

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This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for swelling and dissolution properties using riboflavin as a model drug. Different shapes and sizes of GRDs were tested in dogs to study the gastric retention potential of these devices. The effect of the device on food emptying from the stomach in dogs was also in

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Tseng, Ya-Ching, and 曾雅晴. "Reduction- and pH-Sensitive Polymersomes Formed from Dithiomaleimide-Linked AB2-Type Amphiphilic Block Copolymers for On-Demand Drug Release." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/425pmy.

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Yuh-Tyng, Huang. "A sustained-release formulation study on the hygroscopic drug (pyridostigmine bromide) and the investigation of in vitro/in vivo correlation characteristics." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0011-3001200714382300.

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Huang, Yuh-Tyng, and 黃郁婷. "A sustained-release formulation study on the hygroscopic drug (pyridostigmine bromide) and the investigation of in vitro/in vivo correlation characteristics." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/68541359609978944362.

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博士<br>高雄醫學大學<br>藥學研究所博士班<br>95<br>Pyridostigmine bromide (PB), a highly hygroscopic drug was selected as the model drug. The PB sustained-release (SR) dosage forms (SR tableted-pellets and SR pellets) that were developed by extrusion-spheronization, direct compression and fluid-bed methods using Taguchi experimental and 23 full factorial design. Preceding in vitro studies, Taguchi experimental design was used to optimize formulations and process parameters for the extrusion-spheronization process to prepare drug-containing core pellets. Moreover, 23 full factorial design was utilized to search

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Kuo, Jui-An, and 郭瑞安. "Studies on the pH-Stimuli Responsion and Drug Release in vitro of Low-Molecular-Weight Gelator Based Glycolipids with Histidine Moiety." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/64440171716997730477.

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碩士<br>中原大學<br>化學研究所<br>102<br>The purpose of this article is to study the “pH – Responsive Low –Molecular –Weight Gelators”(pH-R LMWG)and its application in drug delivery system by investigating its strugture,characteristic , and result from gelating. Here we utilize the developed , reversible pH-R LMWG , namely MHS-1 , consisting of D-mannose , para-aminobenzene group , L-histidine , and stearic acid. In the gelating test , MHS-1 can from the stable hydrogel in pure water and the minimum concentration of the gelation is 5 mg/ml. In the pH-reponsive test , the hydrogel formed by MHS-1 can resp

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Kapsi, Shivakumar G. "1) Development and in vivo testing of a gastric retention device (GRD) in dogs : 2) product formulations and in vitro-in vivo evaluation of a) immediate release formulation of itraconazole, b) controlled-release formulation of ketoprofen in adults." Thesis, 1998. http://hdl.handle.net/1957/33331.

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This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated gastric fluid, compressibility of film, shape of the film, and in vivo gastric transit time in the stomach of dog were used as tools to evaluate gastric retention properties. Hydration studies were carried out at 37��C. Evaluation of the device contain

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Schliecker, Gesine [Verfasser]. "Biodegradable polyesters for veterinary drug delivery systems : characterization, in vitro degradation and release behavior of oligolactides and polytartrate / vorgelegt von Gesine Schliecker." 2004. http://d-nb.info/97288694X/34.

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Barreira, Tiago André Preto. "Internship Reports and Monograph Entitled "Key Players in the Dissolution Testing of Modified Release Matrix Tablets"." Master's thesis, 2021. http://hdl.handle.net/10316/99103.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O presente documento inclui os Relatórios de Estágio em Farmácia Comunitária e em Farmácia Hospitalar e a Monografia intitulada “Parâmetros Críticos no Ensaio de Dissolução de Comprimidos Matriciais de Libertação Modificada”. O estágio em Farmácia Comunitária, na Farmácia Machado, em Coimbra, teve uma duração de 648 horas, sob orientação do Dr. João Manuel Baliza Santiago Maia. O estágio em Farmácia Hospitalar, no Hospital Garcia de Orta, EPE, sob a orientação do Dr. Armando Alcobia, tev

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Lai, Yeu-Ching, та 賴雨青. "The Reversible pH-Responsive, and Water-Erosive Low-Molecular-Weight Hydrogelators Based on Glycolipids with Homochiral α,β-Dihydroxyfatty Acid Moiety andits Application to Drug Release in vitro". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/29313676157819180815.

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碩士<br>中原大學<br>化學研究所<br>101<br>The primary concern of this study is to explore the research on a series of glycolipids with homochiral α,β-dihydroxyfatty acid moiety of low-molecular-mass gelators (GR-1~GR-4) and apply to drug delivery system. In gelation test, the gelators GR-1 was developed a stable gel form in purified water, in which the minimal concentration of gelation was 4 mg/mL and the temperature (Tgel) of gel-solution transition was at 64 oC. The self-assembly of intermolecular hydrogen bonding gelator GR-1 was confirmed by 1H NMR spectra. The bilayer-packed lamellar structure within

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"Investigations on the antidiabetic actions of natural products using in vitro and in vivo systems." Thesis, 2006. http://library.cuhk.edu.hk/record=b6074270.

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alpha-Glucosidase from yeast was used to screen for alpha-glucosidase inhibitory activities in Chinese herbal medicines. Seventy crude extracts were studied. The extracts of Semen Fagopyri Esculenti, Herba Euphorbiae Humifusae, Radix Polygoni Multiflori, Cortex Cinnamomi, Radix Paeoniae Rubra, and Radix Paeoniae Alba exhibited alpha-glucosidase inhibitory activities. These herbs have high potential for finding active compounds to develop into new antidiabetic drugs.<br>In this study, an assay technique involving brush border membrane vesicles was developed to screen for glucose uptake inhibito

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