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Journal articles on the topic 'In Vitro Type Drug Release'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Begum, M. Yasmin, and Ali Alqahtani. "Characterization of bilayered matrix-type mucoadhesive buccal films containing tizanidine hydrochloride and piroxicam." Tropical Journal of Pharmaceutical Research 20, no. 11 (2021): 2241–48. http://dx.doi.org/10.4314/tjpr.v20i11.1.

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Purpose: To formulate and characterize tizanidine hydrochloride (TZN) and piroxicam (PRX)-loaded bilayer mucoadhesive buccal films with an intention to improve the bioavailability and patient compliance in pain management.Methods: Bilayer buccal films were prepared by solvent evaporation technique using hydroxypropyl methylcellulose (HPMC) 15cps and polyvinylpyrrolidone (PVP K30 as immediate release (IR) layer forming polymers and HPMC K15 M, PVP K 90 along with various muco adhesive polymers (Carbopol P934, sodium alginate, etc), as sustained release (SR) layer forming polymers. The prepared

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Hamdan, Lama, and Jamila Husian. "FORMULATION AND EVALUATION IN VITRO A MATRIX TYPE OF KETOTIFEN FUMARATE TRANSDERMAL PATCHES FOR ALLERGIC DISEASES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 327. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.20123.

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Objective: Transdermal patches of Ketotifen fumarate (KT) were developed for prolonged effect of the drug, and to protect the patient from allergic symptoms associated with asthma and other allergic diseases.Methods: Matrix type patches were prepared by solvent casting technique using different types of polymers: Hydroxy propyl methyl cellulose (HPMC K15M) and ethyl cellulose to formed the matrix of the patch in different ratios, emulsifying agents were added as a penetration enhancers (Span 60, Tween 60, Cremophor EL) in a ratio 0.025% w/v to the matrix, 10% v/v of glycerin was added as plast

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Tamer, Manar Adnan, Shaimaa Nazar Abd-al Hammid, and Balqis Ahmed. "FORMULATION AND IN VITRO EVALUATION OF BROMOCRIPTINE MESYLATE AS FAST DISSOLVING ORAL FILM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 7. http://dx.doi.org/10.22159/ijap.2018v10i1.22615.

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Objective: The aim of this study was to formulate and in vitro evaluate fast dissolving oral film of practically insoluble bromocriptine mesylate to enhance its solubility and to improve its oral bioavailability by avoiding first pass effect as well as to produce an immediate release action of the drug from the film for an efficient management of diabetes mellitus type II in addition to an improvement of the patient compliance to this patient-friendly dosage form.Methods: The films were prepared by the solvent casting method using hydroxypropyl methylcellulose of grades (E3, E5, E15), polyviny

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Maver, Uroš, and Tina Maver. "The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings." Acta Medico-Biotechnica 15, no. 2 (2023): 41–48. http://dx.doi.org/10.18690/actabiomed.241.

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Purpose: Wound dressings are one of the most commonly used products in wound care. Nowadays, various wound dressings are developed containing different active ingredients, often drugs from different pharmacodynamic groups. Considering the variable and changing environment in each wound type, it is important that the experimental design for evaluating the in vitro drug release of such materials takes into account these different conditions. Methods: For this purpose, Franz diffusion cells for in vitro drug release testing are the method of choice, as they are not only able to simulate dif

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Karim, Samira, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 157–62. http://dx.doi.org/10.3329/bpj.v18i2.24315.

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This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected t

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Venkatesh, P., and M. Durga srinivasrao. "FORMULATION AND INVITRO EVALUATION OF PRAZOSIN HYDROCHLORIDE UNFOLDING TYPE GASTRO RETENTIVE FILM." YMER Digital 21, no. 07 (2022): 460–82. http://dx.doi.org/10.37896/ymer21.07/36.

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The present work is based on the formulation and In-vitro evaluation of a gastroretentive mucoadhesvie based drug delivery system containing prazosin hydrochloride for controlled release. It consists of a drug loaded polymeric film folded into a hard gelatin capsule. After administration film unfolds and its swelling and bioadhesion to the gastric mucosa. Prazosin hydrochloride, a histamine H2 receptor antagonist used for gastroesophageal reflux disease (GERD), duodenal ulcer and gastric ulcer. Prazosin hydrochloride absorbed only in the initial part of gastro intestinal tract (GIT) and has le

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Debatri, Roy, Das Sudipta, Panda Madhurima, et al. "Formulation, Evaluation and Release Kinetics of Low Viscosity Metronidazole Gel with Varying Amount o f Carbopol." Indian Journal of Science and Technology 15, no. 48 (2022): 2690–98. https://doi.org/10.17485/IJST/v15i48.2145.

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Abstract <strong>Objective:</strong> The study is centered on formulation and evaluation of low viscosity metronidazole gel with varying amount of Carbopol. <strong>Methods:</strong> Formulations (F1, F2 and F3) of Metronidazole in gel form were done in varying amounts of Carbopol. Prepared gels were inspected for surface pH, viscosity, spreadability, antimicrobial susceptibility, drug content percentage, in vitro process of drug release, release kinetics and stability testing. <strong>Findings:</strong> Formulation pH was placed in between 5 and 6. Measured viscosity

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Ullah, Md Bashir, Md Rezaul Karim, Md Shamsul Alam, Md Rajib Hassan, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and In vitro Evaluation of Unfolding Type Expandable Gastroretentive Film of Enalapril Maleate." Bangladesh Pharmaceutical Journal 20, no. 2 (2018): 148–56. http://dx.doi.org/10.3329/bpj.v20i2.37868.

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The present work was based on the development and characterization of unfolding type gastroretentive dosage form appropriate for controlled release of enalapril maleate. Drug loaded films were prepared by solid dispersion technique using methocel K15 and eudragit RSPO and eudragit RLPO as polymers and polyethylene glycol 400 (PEG 400) as the plasticizer. The film folded in a capsule shell was shown to unfold in the gastric juice and provide drug release up to 12 h in the acidic medium. Formulations provided satisfactory unfolding characteristics allowing expansion to remain in the stomach. For

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9

Đekić, Ljiljana, and Ana Ćirić. "Modeling of in vitro drug release from polymeric microparticle carriers." Arhiv za farmaciju 72, no. 6 (2022): 591–620. http://dx.doi.org/10.5937/arhfarm72-40229.

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Incorporation of active substances in polymeric microparticles (microencapsulation) is an important technological strategy used in the pharmaceutical industry to improve the functionality, quality, safety and/or therapeutic efficiency of pharmaceutical preparations for different routes of administration. The current focus of research in this field is on the encapsulation of small molecules and macromolecules into microparticles based on biocompatible synthetic polymers and biopolymers, such as polypeptides and polysaccharides, in order to achieve preferable drug release kinetics and many other

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Dhulipalla Mounika, I. Deepika Reddy, K. Sai Chandralekha, Kapu Harika, Ramarao Nadendla, and Madhu Gudipati. "Formulation and in-vitro evaluation of ciprofloxacin HCL floating matrix tablets." International Journal of Research in Pharmaceutical Sciences and Technology 2, no. 1 (2020): 01–06. http://dx.doi.org/10.33974/ijrpst.v2i1.221.

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Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form. Oral route is considered most natural, uncomplicated, convenient and safe due to its ease of administration, patient acceptance and cost-effective manufacturing process. Gastroretentive drug delivery system was developed in pharmacy field and drug retention for a prolonged time has been achieved. The goal of this study was to formulate and in-vitro evaluate Ciprofloxacin HCl controlled release ma

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Iovanov, Rareș Iuliu, Ioan Tomuță, and Sorin Emilian Leucuța. "Development of a reservoir type prolonged release system with felodipine via simplex methodology." Medicine and Pharmacy Reports 89, no. 1 (2015): 128–36. http://dx.doi.org/10.15386/cjmed-526.

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Background and aims. Felodipine is a dihydropyridine calcium antagonist that presents good characteristics to be formulated as prolonged release preparations. The aim of the study was the formulation and in vitro characterization of a reservoir type prolonged release system with felodipine, over a 12 hours period using the Simplex method.Methods. The first step of the Simplex method was to study the influence of the granules coating method on the felodipine release. Furthermore the influence of the coating polymer type, the percent of the coating polymer and the percent of pore forming agent i

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Sharma, Aman, and Abhinav Agarwal. "FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF PLUMBAGIN FOR ANTI-FUNGAL ACTIVITIES." International Research Journal of Pharmacy 12, no. 2 (2021): 23–28. http://dx.doi.org/10.7897/2230-8407.1202122.

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The objective of the current study is to improve the patient compliance and sustained drug release action by herbal medicine which can be achieved by developing alternative drug delivery system. The matrix type transdermal patches containing plumbagin were prepared by solvent evaporation method with different ratios of polymers (HPMC 50cps, PVP K29-32 and EUDRAGIT RS-100). In these matrix type transdermal patches, the PEG (Polyethylene glycol) was used as plasticizer and DMSO (Dimethyl sulfoxide) used as a penetration enhancer. The formulated patches were evaluated for physicochemical paramete

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Saniya, Mubarik*1 Rajni Dubey2 Bhaskar Kumar Gupta3 Mariya Beg4. "A Research Article: Formulation and Evaluation of By-Layered Tablet of Divalproex Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2797–809. https://doi.org/10.5281/zenodo.15099861.

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Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. The present work has been done to formulate bi-layered tablet of Divalproex sodium containing immediate release layer and sustained release layer. The FTIR study revealed that there was no interaction between drug and polymer and combination can be safely prepared. Both layers were prepared by wet granulation technique as poor flow property exhibited by pure drug. The immediate release layer was formulated by using sodium starch

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Posina Rakshitha, B. Deekshi Gladiola, and Cheepurupalli Prasad. "Formulation and biopharmaceutical evaluation of a transdermal patch containing letrozole." International Journal of Pharmaceuticals and Health Care Research 12, no. 4 (2024): 430–37. https://doi.org/10.61096/ijphr.v12.iss4.2024.430-437.

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The skin can be used as the site for drug administration for continuous transdermal drug infusion into the systemic circulation. For the continuous diffusion penetration of the drugs through the intact skin surface membrane-moderated systems, matrix dispersion type systems, adhesive diffusion controlled systems and micro reservoir systems have been developed. Various penetration enhancers are used for the drug diffusion through skin. In matrix dispersion type systems, the drug is dispersed in the solvent along with the polymers and solvent allowed to evaporate forming a homogeneous drug-polyme

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15

Szoleczky, Réka, Mária Budai-Szűcs, Erzsébet Csányi, et al. "Analytical Quality by Design (AQbD) Approach to the Development of In Vitro Release Test for Topical Hydrogel." Pharmaceutics 14, no. 4 (2022): 707. http://dx.doi.org/10.3390/pharmaceutics14040707.

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The aim of our study was to adapt the analytical quality by design (AQbD) approach to design an effective in vitro release test method using USP apparatus IV with a semi-solid adapter (SSA) for diclofenac sodium hydrogel. The analytical target profile (ATP) of the in vitro release test and ultra-high-performance liquid chromatography were defined; the critical method attributes (CMAs) (min. 70% of the drug should be released during the test, six time points should be obtained in the linear portion of the drug release profile, and the relative standard deviation of the released drug should not

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Senthil Kumar, K. L., P D Gokulan, A. Vasanthan, et al. "Preparation and evaluation of matrix type of transdermal patches containing anti –diabetic drug." Indian Journal of Pharmacy and Pharmacology 9, no. 1 (2022): 33–38. http://dx.doi.org/10.18231/j.ijpp.2022.006.

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The current research aims to formulate and evaluated medicated transdermal patches containing an anti-diabetic drug. A good penetration enhancer would improve drug delivery from various polymer-based transdermal patches. Transdermal patches of the matrix type are made. Using various PVP K30, MC ratios and solvent evaporation techniques. All prepared formulations were tested for weight variation, thickness, drug content, moisture content, moisture uptake, flatness, and in vitro drug release. Bath F3 was optimised formula from all formulation baths shows linear zero order release for 24 hours, w

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17

Andreevskaya, SN, TG Smirnova, EN Antonov, et al. "New in vitro model to evaluate kinetics of antimycobacterial drug release from bioresorbable polymeric carriers." MicroRNA in ocular pathology, no. 2020(4) (August 2020): 10–15. http://dx.doi.org/10.24075/brsmu.2020.050.

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Sustained-release drugs against tuberculosis are a promising approach to therapy since they positively affect patient compliance with long regimens, especially when it comes to the multidrug-resistant form of the disease. Conventional UV-visible spectroscopy does not work well with multicomponential culture media used for growing M. tuberculosis. The aim of this study was to develop a method for evaluating the kinetics of anti-tuberculosis drug released from bioresorbable polymeric carriers suitable for screening a wide range of encapsulated prolonged-release drugs and identifying the best per

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18

Dewan, Irin, Swarnali Islam, and Md Sohel Rana. "Characterization and Compatibility Studies of Different Rate Retardant Polymer Loaded Microspheres by Solvent Evaporation Technique: In Vitro-In Vivo Study of Vildagliptin as a Model Drug." Journal of Drug Delivery 2015 (November 12, 2015): 1–12. http://dx.doi.org/10.1155/2015/496807.

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The present study has been performed to microencapsulate the antidiabetic drug of Vildagliptin to get sustained release of drug. The attempt of this study was to formulate and evaluate the Vildagliptin loaded microspheres by emulsion solvent evaporation technique using different polymers like Eudragit RL100, Eudragit RS100, Ethyl cellulose, and Methocel K100M. In vitro dissolution studies were carried out in 0.1 N HCl for 8 hours according to USP paddle method. The maximum and minimum drug release were observed as 92.5% and 68.5% from microspheres, respectively, after 8 hours. Release kinetics

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Jabir, Saba Abdulhadee, and Halah Talal Sulaiman. "PREPARATION AND CHARACTERIZATION OF LAFUTIDINE AS IMMEDIATE RELEASE ORAL STRIP USING DIFFERENT TYPE OF WATER-SOLUBLE POLYMER." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 249. http://dx.doi.org/10.22159/ijap.2018v10i5.28292.

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Objective: The objective of the present study was to design and optimize oral fast dissolving film (OFDF) of practically insoluble drug lafutidine in order to enhance bioavailability and patient compliance especially for a geriatric and unconscious patient who are suffering from difficulty in swallowing.Methods: The films were prepared by a solvent casting method using low-grade hydroxyl propyl methyl cellulose (HPMC E5), polyvinyl alcohol (PVA), and sodium carboxymethyl cellulose (SCMC) as film forming polymers. Polyethylene glycol 400 (PEG400), propylene glycol (PG) and glycerin were used as

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20

Khan, Rahman Ullah, Shefaat Ullah Shah, Sheikh Abdur Rashid, et al. "Lornoxicam-Loaded Chitosan-Decorated Nanoemulsion: Preparation and In Vitro Evaluation for Enhanced Transdermal Delivery." Polymers 14, no. 9 (2022): 1922. http://dx.doi.org/10.3390/polym14091922.

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Nanoemulsions are promising drug delivery systems for the administration of poorly soluble drugs like lornoxicam (LRX) by oral or parenteral routes. Such formulations work perfectly for transdermal delivery of lornoxicam-type drugs. It has also been established that formulating such a delivery system is highly dependent on the presence, type, and concentration of excipients taking part in the formulation. The inherent characteristics of nanoemulsion (NE), i.e., smaller globule size and excipient nature, facilitate the drug’s passage through skin. The current study was aimed at the development

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Goebel, Karin, Mayumi Eliza Otsuka Sato, Dayse Fernanda de Souza, Fábio Seigi Murakami, and Itamar Francisco Andreazza. "In vitro release of diclofenac diethylamine from gels: evaluation of generic semisolid drug products in Brazil." Brazilian Journal of Pharmaceutical Sciences 49, no. 2 (2013): 211–19. http://dx.doi.org/10.1590/s1984-82502013000200003.

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In order for the pharmacological action of a topical dermal drug product to occur, the drug must first be released from the vehicle to be available to penetrate the skin layers and reach the site of action. Drug release is mainly dependent on the characteristics of the formulation. Currently, to register a generic or a similar drug product in Brazil performance testing of topical drug products for local action is not required. In this context, this aim of this study was to evaluate the in vitro release of commercial diclofenac diethylamine gel products available on the Brazilian pharmaceutical

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Wonglertnirant, Nanthida, S. Tipwichai, Praneet Opanasopit, Theerasak Rojanarata, Suwannee Panomsuk, and Tanasait Ngawhirunpat. "Development of Acrylic Matrix Type Ketoprofen Patch." Advanced Materials Research 506 (April 2012): 533–36. http://dx.doi.org/10.4028/www.scientific.net/amr.506.533.

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Ketoprofen transdermal patches (KTPs) were fabricated using an acrylic pressure sensitive adhesive (PSA) polymer. The influence of different factors (amount of PSA, drug content, and pressure applying on the backing membrane during preparation) on the characteristics of ketoprofen patch (thickness, W/A ratio, and adhesiveness of matrix film) and in vitro drug release behavior were investigated. The results revealed the successful fabrication and a good physical appearance of KTPs using acrylic PSA. Microscopic observations, FTIR spectra, and DSC thermograms were permitted to demonstrate that t

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Dr., M. Sunitha Reddy* and Gadam Charitha. "FORMULATION AND IN-VITRO CHARACTERIZATION OF LOSARTAN POTASSIUM AND REPAGLINIDE BILAYER TABLETS." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4207–13. https://doi.org/10.5281/zenodo.1095022.

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The purpose of this study is to formulate and evaluate bilayer anti-hypertensive and anti-diabetic tablets. Bilayer tablet contains Losartan potassium for immediate release and Repaglinide for a sustained release. The bilayer tablets were prepared using crospovidone and sodium starch glycolate as super-disintegrants for the immediate release layer, hydroxyl propyl methyl cellulose K 100M and hydroxyl propyl methyl cellulose K 15M as polymers at various concentrations to retard the release of drug for a period of time. Immediate release layer was prepared by direct compression and wet granulati

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Al-Rajabi, Maha Mohammad, and Teow Yeit Haan. "Influence of Vertical Diffusion Cell Set-Up on In Vitro Silver Sulfadiazine Drug Release from Thermo-Responsive Cellulose Hydrogel." Materials Science Forum 1030 (May 2021): 19–26. http://dx.doi.org/10.4028/www.scientific.net/msf.1030.19.

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In-vitro drug release is used to measure the release of the silver sulfadiazine (SSD) from thermo-responsive cellulose hydrogel using a vertical diffusion cell (VDC). However, selected VDC set-up used by researchers are random, and the studies are lacking in information on the challenging sink conditions during in-vitro drug release study. The objective of this study is to examine the influence of VDC set-up on the in-vitro SSD drug release from thermo-responsive cellulose hydrogel. VDC set-up including receptor medium composition, membrane type, and stirring speed were studied. The results de

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Dasht Bozorg, Behnam, and Ajay K. Banga. "Effect of Different Pressure-Sensitive Adhesives on Performance Parameters of Matrix-Type Transdermal Delivery Systems." Pharmaceutics 12, no. 3 (2020): 209. http://dx.doi.org/10.3390/pharmaceutics12030209.

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Matrix-type transdermal delivery systems (TDS) are comprised of the drug dissolved or dispersed in a pressure-sensitive adhesive (PSA) matrix and are designed to provide a controlled delivery through the skin and into systemic circulation. PSAs can directly affect the permeation, release, and performance characteristics of the system. In this study we aimed to design and characterize transdermal delivery systems formulated with lidocaine—as the model drug—loaded in different PSAs, including silicone, polyisobutylene (PIB), and acrylate. TDS containing lidocaine at its saturation points were pr

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Sha’at, Mousa, Maria Ignat, Liviu Sacarescu, et al. "Multifractal Analysis and Experimental Evaluation of MCM-48 Mesoporous Silica as a Drug Delivery System for Metformin Hydrochloride." Biomedicines 12, no. 12 (2024): 2838. https://doi.org/10.3390/biomedicines12122838.

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Background: This study explored the potential of MCM-48 mesoporous silica matrices as a drug delivery system for metformin hydrochloride, aimed at improving the therapeutic management of type 2 diabetes mellitus. The objectives included the synthesis and characterization of MCM-48, assessment of its drug loading capacity, analysis of drug release profiles under simulated physiological conditions, and the development of a multifractal dynamics-based theoretical framework to model and interpret the release kinetics. Methods: MCM-48 was synthesized using a sol–gel method and characterized by SEM-

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Mubeen, Iqra, Muhammad Zaman, Muhammad Farooq, et al. "Formulation of Modified-Release Bilayer Tablets of Atorvastatin and Ezetimibe: An In-Vitro and In-Vivo Analysis." Polymers 14, no. 18 (2022): 3770. http://dx.doi.org/10.3390/polym14183770.

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The objective of this work was to formulate co-loaded bilayer tablets containing ezetimibe (EZB) and atorvastatin (ATC). ATC loaded in the immediate-release (IR) layer is an HMG CoA reductase inhibitor, while EZB, added in the sustained-release (SR) layer, is a lipid-lowering agent. This study was conducted to evaluate the effects of polymer on the formulation and characterization of bilayer tablets, as well as the therapeutic impact of the concurrent use of both drugs having a sequential release pattern. To obtain the optimized results, four different formulations with variable compositions w

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Szulc-Musioł, Beata, Lucyna Bułaś, and Barbara Dolińska. "Formulation, characterization, and in vitro evaluation release nimesulide from different rectal suppository bases." Acta Poloniae Pharmaceutica - Drug Research 79, no. 6 (2023): 865–73. http://dx.doi.org/10.32383/appdr/159289.

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Nimesulide is a poorly water-soluble, non-steroidal anti-inflammatory drug for both systemic and topical application. The aim of the study was to assess the influence of the type of base and surfactants (Tween80, Span80, soy lecithin, sodium lauryl sulphate) on drug release from rectal suppositories. Suppositories were prepared in the Unquator® using Cacao butter, Witepsol H15 and PEG1500:PEG400 as a base. The physicochemical properties of the prepared suppositories were in accordance to the Pharmacopoeia’s requirements. In vitro dissolution profile of the formulations was evaluated using USP

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Kim, Hyun-Jung, Young-Il Jeong, Sung-Ho Kim, Young-Moo Lee, and Chong-Su Cho. "Clonazepam release from core-shell type nanoparticlesin vitro." Archives of Pharmacal Research 20, no. 4 (1997): 324–29. http://dx.doi.org/10.1007/bf02976194.

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Pushpalatha, D., Waris Khan Abdul, K. Manjunath, and S. Brunda. "Formulation and evaluation of lovastatin loaded nanosponges." World Journal of Advanced Research and Reviews 11, no. 3 (2021): 041–56. https://doi.org/10.5281/zenodo.5558745.

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Nanotechnology mediated drug delivery has been reported to enhance the drug efficacy, bioavailability, reduced toxicity and improve patient compliance by targeting the cells and tissues to elicit the desired pharmacological action. The main aim of the study was to formulate lovastatin loaded nanosponges and to evaluate them. Lovastatin loaded nanosponges were prepared by Emulsion solvent diffusion method using different polymers (Ethyl cellulose, Polyvinyl alcohol, β-cyclodextrin, Pluronic F68, Hydroxy Propyl β- cyclodextrin). The FTIR test is conducted as the preliminary test, by th

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Kishor, H. B., Manjunath K, and V. Kulkarni Suresh. "Formulation and evaluation of Glibenclamide loaded Nanosponges." World Journal of Advanced Research and Reviews 20, no. 3 (2023): 850–62. https://doi.org/10.5281/zenodo.12748907.

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Nanotechnology mediated drug delivery has been reported to enhance the drug efficacy, bioavailability, reduced toxicity and improve patient compliance by targeting the cells and tissues to elicit the desired pharmacological action. The main aim of the study was to formulate Glibenclamide loaded nanosponges and to evaluate them. Glibenclamide loaded nanosponges were prepared by Emulsion solvent diffusion method using different polymers (Ethyl cellulose, β- cyclodextrin, Hydroxy Propyl β- cyclodextrin, Pluronic F68). The FTIR test is conducted as the preliminary test, by this test ther

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T.Salih, Zainab. "In vitro Evaluation of Tinidazole Bioadhesive Vaginal Gels." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 19, no. 2 (2017): 64–69. http://dx.doi.org/10.31351/vol19iss2pp64-69.

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Many trials were made to prepare Tinidazole 2% as bioadhesive vaginal gels using different gel bases including hydroxypropyl methyl cellulose (3 and 4% w/w), methylcellulose (3 and 4%w/w) and carboxymethylcellulose (2 and 3% w/w) .Swelling index of the polymers,pH , viscosity , bioadhesive force , and in-vitro drug release to the simulating vaginal fluid (S.V.F.) were investigated for all the prepared bioadhesive gels . The mechanism of drug release from the gel bases was also investigated. The results revealed that C MC 3% gave the highest viscosity and bioadhesive strength with the low

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Babic, Marija, Jovana Jovasevic, Jovanka Filipovic, and Simonida Tomic. "Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid." Chemical Industry 66, no. 6 (2012): 823–29. http://dx.doi.org/10.2298/hemind120406073b.

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The aim of this paper is to propose equations for the diffusion of drugs for investigated drug/hydrogel systems using the parameters affecting the transport of drug through poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)), poly(2-hydroxyethyl acrylate/itaconic acid) (P(HEA/IA)), and poly(2-hydroxyethyl methacrylate/poly(alkylene glycol) (meth)acrylates) (P(HEMA/BIS)) copolymeric hydrogels. Different monomer types, as well as the variable content of some components in hydrogel composition (the amount of ionizable comonomer (IA) and different type of nonionic poly(alkylene glycol) (m

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Tomer, Kajal, and Dilip Kumar Gupta. "FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE FLOATING MICROBALLOONS OF POORLY WATER-SOLUBLE DRUG DIACEREIN." International Research Journal Of Pharmacy 15, no. 5 (2021): 8–12. http://dx.doi.org/10.7897/2230-8407.1205134.

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The drug can be released in a controlled manner using a gastro retentive dosage type. The main focus on the novel technological advances in the floating drug delivery method for gastric retention. The preparation of diacerein micro balloon is done by solvent diffusion method, using acrylic polymer like Eudragit S 100 and HPMC K4 M. The various evaluation of the prepared floating microsphere like its % yield, drug entrapment efficiency, particle size in-vitro dissolution, buoyancy, was studied. The floating microsphere was found to be spherical and range from 85 μm - 192 μm. Whereas the buoyanc

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Srushti and Anand Kumar Yegnoor. "Design and optimization of ketoprofen floating tablets." Magna Scientia Advanced Biology and Pharmacy 11, no. 2 (2024): 080–89. http://dx.doi.org/10.30574/msabp.2024.11.2.0026.

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The objective of the present research work is design and optimize hydrodynamically balanced Ketoprofen (KF) floating tablets to enhance their gastric residence time because it has a narrow absorption window, poor bioavailability and short half-life. The Central Composite design is used to optimize the amount of Guar gum (X1) and HPMC K100M (X2) as two independent variables and study how they affect the two response such as in vitro Buoyancy lag time (Y1) and in vitro drug release (t50 Y2). Eleven trials were developed through the Central Composite design (CCD) to study all the optimal interact

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Madhavi, Reddy*, and Madireddy Mamata Dr. "DEVELOPMENT AND CHARACTERIZATION OF ZOLMITRIPTAN MUCOADHESIVE BUCCAL PATCHES." World Journal of Pharmaceutical Science and Research 4, no. 2 (2024): 538–48. https://doi.org/10.5281/zenodo.15253872.

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The objective of present study was to develop matrix type buccal patch therapeutic systems of Zolmitriptan using natural polymers as matrix formers. Zolmitriptan buccal patches were developed by using solvent casting technique. Various physicochemical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption parameters like mucoadhesive strength, force of adhesion, and bond strength were evaluated. An <em>in vitro</em> drug release study was designed, and it was carried out using commercial semipermeable membrane. Results reve

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Jia, Xiao Yun, Ya Zhen Wu, Qing Cai, Xiao Ping Yang, De Ping Liu, and Yuan Hua Lin. "Modulating Release of Metoprolol Tartrate with Nanostructured Silica Particles." Key Engineering Materials 602-603 (March 2014): 55–58. http://dx.doi.org/10.4028/www.scientific.net/kem.602-603.55.

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To develop a kind of gastrointestinal timed-release preparation for Metoprolol Tartrate, nanostructured silica particles were chose for the purpose. Briefly, MCM-41 type mesoporous silica nanospheres with a size of 100-200 nm were synthesized through the reaction of tetraethyl orthosilicate (TEOS) in the water medium at 353 K, with introducing some cetyltrimethyl ammonium bromide (CTAB) as porogens. Various analytical methods, including FT-IR, XRD, TEM, N2 physisorption and thermal analysis, were applied to characterize the final products. Metoprolol Tartrate was then loaded into the mesoporou

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Kabir, Abul Kalam Lutful, Shimul Halder, Madhabi Lata Shuma, and Abu Shara Shamsur Rouf. "Formulation Development and in vitro Evaluation of Drug Release Kinetics from Sustained Release Aceclofenac Matrix Tablets using Hydroxypropyl Methyl Cellulose." Dhaka University Journal of Pharmaceutical Sciences 11, no. 1 (2012): 37–43. http://dx.doi.org/10.3329/dujps.v11i1.12485.

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The objective of the present study was to develop a once-daily sustained release matrix tablet of Aceclofenac using hydroxypropyl methyl cellulose (Methocel K 100M CR) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. The tablets were prepared by direct compression method. The powder blends were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity and drug content etc. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in vitro

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Al-Abadi, Ahmed N., and Alaa A. Abdul Rassol. "Preparation and in-vitro evaluation of floating microspheres of gabapentin." Kufa Journal For Veterinary Medical Sciences 2, no. 1 (2011): 77–92. http://dx.doi.org/10.36326/kjvs/2011/v2i14047.

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Gabapentin dosage form could be designed to release the drug in the stomach at a rate providing the maximum amount of drug absorbable by the upper intestinal segment using the multiple- unit floating system to increase the gastric residence time (GRT) of the dosage forms. The floating microspheres were prepared by the solvent evaporation method using polymers ethyl cellulose and cellulose acetate. The microspheres were characterized for their particle size, shape, percentage yield, drug entrapment, buoyancy ratio, drug- polymer interaction and in-vitro drug release kinetics. In addition, effec

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Alatraqchi, Faten Ibraheem, and Fatima J. AL Gawhri. "Preparation and In-Vitro Evaluation as an Oral Microsponge Tablet of Baclofen." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 28, no. 1 (2019): 75–90. http://dx.doi.org/10.31351/vol28iss1pp75-90.

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The aim of the present study is to formulate floating effervescent microsponge tablet of the narrow absorption window drug, Baclofen (BFN) for controlling drug release and thereby decrease the side effect of the drug. The microsponges of BFN were prepared by non-aqueous emulsion solvent diffusion method (oil in oil emulsion method). The effects of drug: polymer ratio, stirring time and type of Eudragit polymer on the physical characteristics of microsponges were investigated and characterized for production yield, loading efficiency, particle size, surface morphology, and in vitro drug release

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Ramkanth S, Aravind M, Gayathri R, Benedict Jose C, Swetha V, and Mohan S. "Formulation optimisation and characterisation of azithromycin proniosome." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (2021): 477–86. http://dx.doi.org/10.26452/ijrps.v12i1.4093.

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The research was featured to formulate, characterise and optimise the Azithromycin Proniosome using the three-factor three-level Box Behnken scheme. The independent variables chosen were span 20 (X1), span 80 (X2) and phospholipids (X3) to assess their individual and shared response on entrapment efficiency (Y1) and % drug released at six h (Y2). Based on Box Behnken design, 15 formulations were prepared and optimised using Design Expert Version 12.0.10.0. The entrapment efficiency and in-vitro drug release were exposed to different regressions to setup a polynomial equation. The counterplots

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Mohapatra, Prasanta Kumar, Ch Prathibha, Vivek Tomer, Mandeep Kumar Gupta, and Satyajit Sahoo. "DESIGN AND DEVELOPMENT OF LOSARTAN POTASSIUM FLOATING DRUG DELIVERY SYSTEMS." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 168. http://dx.doi.org/10.22159/ijap.2018v10i6.28782.

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Objective: The current study was projected to prepare a losartan potassium gastroretentive drug delivery system (GRDDS) of floating tablets was planned to enhance the gastric residence time, thus prolong the drug release.Methods: Effervescent floating matrix tablets of losartan potassium were prepared by direct compression technique using polymers like HPMC k4m, guar gum, and gum karaya, with lubricants magnesium stearate and talc. In the present study, sodium bicarbonate was incorporated as a gas generating agent. Total nine formulations were designed and evaluated for pre-compression paramet

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Salman, B. Syed, and Mohd Abdul Hannan Baig. "Formulation and evaluation of nanoparticulate ofloxacin ophthalmic gel using ionic gelation method." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 2 (2019): 73–78. http://dx.doi.org/10.33974/ijrpst.v1i2.148.

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Oflaxacin is an ophthalmic and topical anti-bacterial agent used in the management of Allergic conjunctivitis, Trachoma, Blepharitis. The basic idea behind the development of such a system is to maintain a sustained drug release from the dosage form. Oflaxacin is suitable candidate for formulation into sustained dosage form in order to prolong the release of drug. The drug-excipient compatibility studies were carried out by using FTIR technique. Based on the results, excipients were found to be compatible with ofloxacin. In preformulation study, estimation of Ofloxacin was carried out by systr

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Preety, Kumari* Arti Kori Shivanand Patil. "Enhancing Biopharmaceutical Attributes Of Nateglinide Through Floating Microsphere Delivery: Development And Evaluation." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 639–54. https://doi.org/10.5281/zenodo.12702695.

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Gastroretentive dosage forms might be used as a controlled-release drug delivery system. Gastroretentive floating medicines extend the duration for a drug's presence in the stomach & allow for controlled dispensing of a range of drugs as their size is less than that in stomach juices. The aim of this study is to develop and evaluate floating microspheres that improve the patient's experience using nateglinide as a model drug for type-2 diabetes mellitus. Material & Method: By using ethyl cellulose and Eudragit S-100 as release-delaying polymers, float spheres were created by

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Pundir, Sarika, and Ashutosh Badola. "Formulation and Evaluation of Atenolol and Indapamide SR Matrix Tablets for Treatment of Hypertension." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (2014): 2450–58. http://dx.doi.org/10.37285/ijpsn.2014.7.2.7.

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In the present study we have formulated (F1 to F6) matrix tablets of atenolol and indapamide for the management of hypertension. As in simultaneous estimation of these drugs it was found that a confined release can be formulated. In the formulation of SR matrix tablet by using different concentration of delayed release agent DCP and pregelatinized starch as disintegrant we prepared tablets by wet granulation method. For sustained release action HPMC polymers were used for film coating. Preformulation studies were performed prior to compression. The compressed SR matrix tablets were evaluated f

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Alam, Md Shamsul, Jakir Ahmed Chowdhury, Sams Mohammad Anowar Sadat, and Md Selim Reza. "Development and Evaluation of Salbutamol Sulphate Loaded Ethyl Cellulose Microcapsules using Emulsion Solvent Evaporation Technique." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 132–36. http://dx.doi.org/10.3329/bpj.v18i2.24311.

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Ethyl cellulose (EC) microcapsules containing Salbutamol sulphate (SS) were prepared through emulsion-solvent evaporation technique. Microcapsules were compressed and in-vitro release profiles were studied from both microcapsules and their compressed matrix tablets. Different amounts of drug were added in order to obtain various drugs to polymer ratios and it was found that the size of microcapsules reduced with the increase in core loading. In the preparation of formulations, Tween 80 was used as an emulsifying or dispersing agent and light liquid paraffin (LLP) was used as oil phase. The in-

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Shravya, Chinthakindi, and D. Adukondalu. "Design and Development of Propranolol Hydrochloride Transdermal Patches: In Vitro and Ex Vivo Characterization." Pharmaceutics and Pharmacology Research 3, no. 1 (2020): 01–07. http://dx.doi.org/10.31579/2693-7247/007.

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The main aim of this investigation is to design and develop matrix type transdermal patches of Propranolol Hydrochloride which is an anti-hypertensive drug. These matrix type transdermal patches were prepared by “Solvent Casting Technique” using drug, HPMC E15 and Eudragit L 100 in the ratio of 1:6, 1:6.5, 1:7, 1:7.5, 1:8, 1:8.5, 1:9, 1:9.5. All formulations carried 20%v/w of PEG-600 as plasticizer. The prepared patches were characterized for various physicochemical parameters like weight, thickness, folding endurance, drug content, percent moisture content, percent moisture absorption, in vit

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Rahman, Md Ziaur, Sayed Koushik Ahamed, Sujan Banik, and Mohammad Salim Hossain. "Release Profile of Losartan Potassium from Formulated Sustained Release Matrix Tablet." Bangladesh Pharmaceutical Journal 16, no. 2 (2015): 177–83. http://dx.doi.org/10.3329/bpj.v16i2.22301.

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The present study was undertaken to develop sustained release (SR) matrix tablets of Losartan potassium, an angiotensin-II antagonist for the treatment of hypertension. The tablets were prepared by direct compression method along with Kollidon SR and Methyl Cellulose as release retardant polymers. The evaluation involves two stages- the physical properties studies of tablets and in vitro release kinetics assessment. The USP paddle method was selected to perform the dissolution test and 900 ml phosphate buffer of pH 6.8 was used as dissolution medium at 50 rpm at 370C. The release kinetics were

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Mzoughi, Jihane, Thierry Vandamme, and Valeriy Luchnikov. "Biphasic Drug Release from Rolled-Up Gelatin Capsules with a Cylindrical Cavity." Pharmaceutics 13, no. 12 (2021): 2040. http://dx.doi.org/10.3390/pharmaceutics13122040.

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Biphasic drug delivery systems are used for quick release of a specific amount of drug for immediate amelioration of a patient’s state, followed by sustained release, to avoid repeated administration. This type of delivery is often necessary for pain management and the treatment of many pathologies, such as migraines, hypertension, and insomnia. In this work, we propose a novel architecture of a biphasic release media that does not need the rapidly disintegrating layer and that allows for easily setting the sustained release rate. A drug-containing capsule is made by rolling up a thermally cro

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de la Paz, Nilia, Dania Pérez, Mirna Fernández, et al. "In vitro release of dibucaine hydrochloride from chitosan semisolid vehicles: emulsion and hydrophilic gels." Journal of Pharmacy & Pharmacognosy Research 5, no. 1 (2017): 96–105. http://dx.doi.org/10.56499/jppres16.164_5.2.96.

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Context: Chitosan has received attention as a functional, sustainably renewable, nontoxic and biodegradable biopolymer for pharmaceutical applications. Aims: To evaluate the release of dibucaine hydrochloride from semisolid vehicles of oil/aqueous type emulsion and aqueous gels, stabilized by using chitosan (CH) or chitosan acetate (CHAc). Methods: Emulsions were developed by varying the emulsifying agent: polysorbate 80, CH or CHAc and by combining CH with polysorbate 80 or CHAc with polysorbate 80. The hydroxypropylmethyl cellulose F4M was added as a stabilizing agent in gel formulations. Th

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