Relevant bibliographies by topics / In vitro uvolňování léčiva

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  1. Dissertations / Theses

Academic literature on the topic 'In vitro uvolňování léčiva'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Dissertations / Theses on the topic "In vitro uvolňování léčiva"

1

Oborná, Jana. "Řízené uvolňování léčiv z biodegradabilních hydrogelů." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-385283.

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This dissertation is focused on the controlled release of drugs from a biodegradable amphiphilic hydrogel based on hydrophobic poly(lactic acid), poly(glycolic acid) and hydrophilic poly(ethylene glycol) (PLGA-PEG-PLGA, ABA) and its modification with itaconic anhydride (ITA). The resulting ,-itaconyl(PLGA-PEG-PLGA) copolymer is referred to as ITA/PLGA-PEG-PLGA/ITA or ITA/ABA/ITA. Itaconic acid provides reactive double bonds and a functional carboxyl group at the ends of the PLGA-PEG-PLGA copolymer chain, thereby rendering the modified ITA/ABA/ITA copolymer less hydrophobic and offering the pos
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2

Policianová, Olívia. "Studium struktury a segmentové dynamiky farmaceutických materiálů na bázi tuhých disperzí léčiv v polymerních matricích pomocí NMR spektroskopie pevného stavu." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-338479.

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Highly-exact structural characterization is the crucial step in the development and manufacturing process of pharmaceutical materials. Their structural composition is, however, often very complex and hardly identifiable. The eligible way for obtaining definite structural interpretation of these systems appears the high-resolution solid-state nuclear magnetic resonance (ssNMR) spectroscopy. For this purpose the reliable tool - the ssNMR toolbox for comprehensive characterization of various pharmaceutical solids is described. The rigorous optimization of ssNMR techniques is carried out on enormo
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Batěk, Jan. "Studium kinetiky uvolňování hydrofobního léčiva paklitaxelu do hydrogelů." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-448840.

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In this diploma thesis, hydrogels based on 2-hydroxymethacrylate (HEMA) were studied. Their possible use to study the release kinetics of the hydrophobic anticancer drug paclitaxel (PTX) was investigated in order to approach the conditions simulating in vivo environments. Paclitaxel is a drug with strong side effects, which can be partially prevented by appropriate local application. In this work, polylatide (PLA) nanofibers with incorporated drug was studied. Furthermore, the effect of the addition of polyethylene glycol (PEG) with a molecular weight of 20 kDa and CD to the structure of PLA n
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Bittner, Matyáš. "Hvězdicovité polymerní nosiče léčiv pro cílenou dopravu a pH-řízené uvolňování léčiva." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-323825.

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This diploma thesis brings new data about design, synthesis, physico-chemical characterisation and biological efficacy of the novel star-like HPMA-based conjugates intended for treatment of solid tumors. Recently, many different water-soluble drug delivery systems based on N-(2- hydroxypropyl)methacrylamide (HPMA) copolymers have been described. Here, we report synthesis and physico-chemical characterisation of high molecular weight star-like HPMA- based polymer carriers with low polydispersity prepared by controlled grafting of HPMA copolymers onto PAMAM dendrimer core. With the aim to keep t
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5

Kotrbová, Věra. "Studium aktivačního a detoxikačního metabolismu protinádorového léčiva ellipticinu systémem cytochromů P450 in vitro a in vivo…" Doctoral thesis, 2008. http://www.nusl.cz/ntk/nusl-274194.

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Gen. Physiol. Biophys. (2006), 25, 245-261 245 Oxidation Pattern of the Anticancer Drug Ellipticine by Hepatic Microsomes - Similarity Between Human and Rat Systems M. Stiborová1 , L. Bořek-Dohalská1 , D. Aimová1 , V. Kotrbová1 , K. Kukačková1 , K. Janouchová1 , M. Rupertová1 , H. Ryšlavá1 , J. Hudeček1 and E. Frei2 1 Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic 2 Division of Molecular Toxicology, German Cancer Research Center, Heidelberg, Germany Abstract. Ellipticine is an antineoplastic agent, whose mode of action is based mainly on DNA intercal
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6

Matiašková, Zuzana. "Role vybraných ABC a SLC transportérů v přestupu maraviroku přes buněčné membrány: vliv na transport v placentě." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397868.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and toxikology Student: Zuzana Matiašková Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Role of selected ABC and SLC transporters in transmembrane permeability of maraviroc: effect on transport in placenta Antiretroviral drug maraviroc is an inhibitor of CCR5-trophic HIV virus and belongs to the group of entry inhibitors. Nowadays, maraviroc is administered as part of combination antiretroviral therapy (cART) primarily in adults, children over the age of two and pregnant women to red
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7

Skalský, Ivo. "Současné možnosti ovlivnění dlouhodobé průchodnosti koronárních bypassů." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-326152.

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The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester system releasing sirolimus on intimal hyperplasia of autologous grafts. The controlled-release system comprises a polyester mesh coated with a sirolimus-eluting copolymer of L lactic acid and ε-caprolactone system designed to be wrapped around an autologous venous graft during its implantation. In vitro sirolimus release and its effects on smooth muscle and endothelial cells were assessed. In vitro, the copolymer-coated poly
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8

Jahodová, Michaela. "In vitro a ex vivo studium lékových interakcí antiretrovirálních látek na střevních ATP-vázajících lékových transportérech." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-370996.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Bc. Michaela Jahodová Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: In vitro and ex vivo study of drug-drug interactions of antiretrovirals on intestinal ATP-binding drug transporters The absorption of orally administered drugs takes place especially in the intestine, where it can affect by the activity of drug's ABC transporters located on the apical membrane of the intestinal epithelium. Study of drug interactions in intestinal ABC transporters is essenti
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