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1

Bogdanova, E. V., E. I. Melnikova та A. V. Grebenshchikov. "Digestibility of β-lactoglobulin hydrolysate in in vivo experiments". Dairy Industry, № 3 (2019): 41–42. http://dx.doi.org/10.31515/1019-8946-2019-3-41-42.

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2

Vozianov, A. F. "«Microflora» Experiment Influence of space flight factors on biological properties of human resident microflora: experiments in vivo and in vitro." Kosmìčna nauka ì tehnologìâ 6, no. 4 (2000): 127. http://dx.doi.org/10.15407/knit2000.04.144.

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3

Ivanov, V. V., A. V. Ratkin, lu A. Pfarger, et al. "HYPOLIPIDEMIC EFFECT OF GROSSMIZINE AT THE EXPERIMENTS IN VIVO AND IN VITRO." Siberian Medical Review, no. 6 (2015): 43–48. http://dx.doi.org/10.20333/25000136-2015-6-43-48.

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4

Havlicek, V., M. Lopatarova, S. Cech, et al. "In vivo culture of bovine embryos and quality assessment of in vivo vs. in vitro produced embryos." Veterinární Medicína 50, No. 4 (2012): 149–58. http://dx.doi.org/10.17221/5608-vetmed.

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Routine access to the bovine oviduct for in vivo culture accomplishes various demands on embryo production for scientific as well as commercial purposes. The experiments conducted in the present study focused on the efficiency of recovery methods after temporary in vivo culture of bovine embryos in oviducts of the homologous species using transvaginal endoscopy (Experiment I) and on the quality assessment of recovered blastocysts (Experiment II). In Experiment I in vitro matured oocytes were fertilized, cultured for 1 to 3 days and transferred unilaterally into the ipsilateral oviducts of 54 heifers by the means of transvaginal endoscopy. After 4 to 6 days of in vivo culture embryos were re-collected either by non-surgical flushing of uterine horns (U-group) or by combined flushing of the oviducts and uterine horns (OU-group). In total the recovery rate was 38.4% (780/2029). After flushing at day seven, 106 blastocysts (blastocyst rate: 13.6% ) were found. The additional 24 h of in vitro culture (day eight) resulted in 153 blastocysts (blastocyst rate: 19.6% ). The recovery rate in the OU-group was twice as efficient as in the U-group (390/1358 vs. 390/671, P < 0.01). The recovery rates among the different stages of transferred embryos did not differ significantly; likewise cross-effects among the stages and the recovery methods were non-significant. The recovery methods (P < 0.001) and the interaction between the recovery methods and the stages of transferred embryos (P < 0.01) had an influence on blastocyst yields on day seven (U-group 37/1358 vs. OU-group 69/671) and day eight (U-group 48/1358 vs. OU-group 105/671). In Experiment II embryo quality was assessed by the survival rate of blastocysts after freezing in ethylene glycol. Day seven embryos were produced in vitro (in vitro group D7) or by IVM/IVF followed by a combined culture procedure (2 to 3 days in vitro prior to 4 to 5 days in vivo) (in vivo group D7) or after superovulation and collection at day seven (superovulation group). Embryos from in vitro group D7 re-expanded only for 6 h after thawing, embryos from in vivo group D7 and superovulation group were alive for 24 h and 72 h of culture, respectively. Only embryos derived by superovulation showed hatching activity. Blastocysts from the in vitro group D7 and the in vivo group D7 that were held in culture medium for additional 24 h (day eight) showed an analogous post-thawing culture behaviour. In conclusion, the results of the present study demonstrated that some embryos transferred for in vivo culture remain in the oviduct even at day seven. Hence, combined flushing of oviducts and uterine horns after in vivo culture in the bovine oviduct is necessary for effective embryo re-collection. The quality of recovered embryos after temporary in vivo culture assessed by cryotolerance was in-between those produced in vitro or recovered after superovulation.
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5

Yonezawa, T., Y. Abe, T. Mabuchi, et al. "The theraphy of disc herniation with laser: in vivo experiments." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 9, no. 3 (1988): 225–28. http://dx.doi.org/10.2530/jslsm1980.9.3_225.

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6

Xavier, Fatima Grace, Anbarasan Balu, Shanmuganathan Seetharaman, Akila Lakshmikandhan, and Arul Amutha Elizabeth Lawrence. "Alternatives to In vivo Experiments – A Pandect." Research Journal of Pharmacy and Technology 12, no. 9 (2019): 4575. http://dx.doi.org/10.5958/0974-360x.2019.00786.8.

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7

Buss, Sarah. "Experiments In Vivo, In Vitro, and In Cathedra." Ethics 124, no. 4 (2014): 860–81. http://dx.doi.org/10.1086/675874.

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8

Astolfo, A., E. Schültke, R. H. Menk, C. Hall, B. Juurlink, and F. Arfelli. "X-ray cell tracking: from ex-vivo to in-vivo experiments." Journal of Instrumentation 8, no. 06 (2013): C06010. http://dx.doi.org/10.1088/1748-0221/8/06/c06010.

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9

Graf, Laurie L., David A. Young, David C. Kressin, Richard A. Marlar, Ginette B. Jacob, and Peter H. Hinderling. "Importance of Using Controls in in Vivo Experiments." Radiology 233, no. 1 (2004): 297–99. http://dx.doi.org/10.1148/radiol.2331040521.

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10

Sheu, Joen R., George Hsiao, Yen M. Lee, and Mao H. Yen. "Antithrombotic Effects of Tetramethylpyrazine in In Vivo Experiments." International Journal of Hematology 73, no. 3 (2001): 393–98. http://dx.doi.org/10.1007/bf02981969.

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11

Griffin, Julian L., Andrew W. Nicholls, Clare A. Daykin, et al. "Standard reporting requirements for biological samples in metabolomics experiments: mammalian/in vivo experiments." Metabolomics 3, no. 3 (2007): 179–88. http://dx.doi.org/10.1007/s11306-007-0077-z.

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12

Čorović, Selma, Lluis M. Mir, and Damijan Miklavčič. "In Vivo Muscle Electroporation Threshold Determination: Realistic Numerical Models and In Vivo Experiments." Journal of Membrane Biology 245, no. 9 (2012): 509–20. http://dx.doi.org/10.1007/s00232-012-9432-8.

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13

NAKAMURA, S. "In vivo experiments of $gamma;HuEPO-derived hypertension." American Journal of Hypertension 12, no. 4 (1999): 52. http://dx.doi.org/10.1016/s0895-7061(99)80166-6.

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14

Brown, Daniel B., Craig B. Glaiberman, Anthony W. Allen, et al. "Creation of Radiopaque Thrombi for In Vivo Experiments." Journal of Vascular and Interventional Radiology 11, no. 9 (2000): 1222–26. http://dx.doi.org/10.1016/s1051-0443(07)61368-2.

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15

Wachtveitl, Josef, and Andreas Zumbusch. "Azobenzene: An Optical Switch for in vivo Experiments." ChemBioChem 12, no. 8 (2011): 1169–70. http://dx.doi.org/10.1002/cbic.201100185.

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16

Olivier ten Hallers, E. J., Eduard B. Van der Houwen, Henri A. M. Marres, et al. "In vivo experiments with tracheostoma tissue connector prototypes." Journal of Biomedical Materials Research Part A 82A, no. 1 (2007): 62–72. http://dx.doi.org/10.1002/jbm.a.31074.

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17

Doi, K., K. Fukamachi, H. Harasaki, et al. "IN VIVO EXPERIMENTS OF MAGSCREW TOTAL ARTIFICIAL HEART." ASAIO Journal 47, no. 2 (2001): 132. http://dx.doi.org/10.1097/00002480-200103000-00127.

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18

KOHNO, Shigekatsu, Hideki YAMAMURA, Katsuya OHATA, et al. "Antiallergic effects of mequitazine. 2. In vivo experiments." Folia Pharmacologica Japonica 92, no. 2 (1988): 159–65. http://dx.doi.org/10.1254/fpj.92.159.

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19

Lepore, E., S. Brianza, F. Antoniolli, M. Buono, A. Carpinteri, and N. Pugno. "Preliminary In Vivo Experiments on Adhesion of Geckos." Journal of Nanomaterials 2008 (2008): 1–5. http://dx.doi.org/10.1155/2008/194524.

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We performed preliminary experiments on the adhesion of a Tokay gecko on surfaces with different roughness, with or without particles with significant different granulometry, before/after or during the moult. The results were analyzed using the Weibull statistics.
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20

Artemov, Sergey A., Alexander N. Belyaev, Olga S. Bushukina, et al. "Optimization of endovenous laser coagulation: in vivo experiments." Lasers in Medical Science 35, no. 4 (2019): 867–75. http://dx.doi.org/10.1007/s10103-019-02874-6.

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21

Khinovker, V. V., and E. V. Khinovker. "Animal models of chronic pain. In vivo experiments." Regional Anesthesia and Acute Pain Management 14, no. 3 (2021): 121–29. http://dx.doi.org/10.17816/1993-6508-2020-14-3-121-129.

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As a result of population aging and increasing of comorbide patients procent, chronic pain nowadays is the one of the most important medical problems and its treatment becoming one of progressive and popular researching topics. First part of acute or chronic pain research is a model that meets the specified criteria. First model of cronic pain sciatic nerve damaging was founded and proven more than 30 years ago. Nowadays there is a lot of in vivo and in vitro models that matched with different pathologies and also mechanisms of chronic nociceptive and neuropathic pain on different levels have been learned. In this article we review the most effective and often used rat models of chronic pain its mechanisms and assessment methods. The information based on the most citated articles for 10 years.
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22

Dmytrukha, N. M., S. P. Lugovskoy, and O. S. Lahutina. "Assessment of Fe2O3 nanoparticles impact on functional activity of rats’ peritoneal macrophages in experiments in vitro and in vivo." Ukrainian Journal of Occupational Health 2015, no. 3 (2015): 28–33. http://dx.doi.org/10.33573/ujoh2015.03.028.

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23

Talalaeva, O. S., Ya F. Zverev, and S. V. Zamyatina. "COMPARATIVE ASSESSMENT OF HISTOCHROME’S ANTIOXIDANT AND PROOXIDANT ACTIVITIES IN TERMS OF IN VITRO AND IN VIVO EXPERIMENTS." Bulletin of Medical Science, no. 4(8) (2017): 30–35. http://dx.doi.org/10.31684/2541-8475.2017.4(8).30-35.

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24

Jamis-Dow, Carlos A., Michael L. Pearl, Paul B. Watkins, Debbie S. Blake, Raymond W. Klecker, and Jerry M. Collins. "Predicting Drug Interactions In Vivo from Experiments In Vitro." American Journal of Clinical Oncology 20, no. 6 (1997): 592–99. http://dx.doi.org/10.1097/00000421-199712000-00013.

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25

Shen, Ming Y., Joen R. Sheu, George Hsiao, Yen M. Lee, and Mao H. en. "Antithrombotic Effects of Magnesium Sulfate in In Vivo Experiments." International Journal of Hematology 77, no. 4 (2003): 414–19. http://dx.doi.org/10.1007/bf02982655.

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26

Bonina, Francesco Paolo, Maria Luigia Giannossi, Luca Medici, Carmelo Puglia, Vito Summa, and Fabio Tateo. "Diclofenac-hydrotalcite: In vitro and in vivo release experiments." Applied Clay Science 41, no. 3-4 (2008): 165–71. http://dx.doi.org/10.1016/j.clay.2007.10.008.

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27

Engi, Helga. "Perspectives in Cancer Chemotherapy, in vitro and in vivo Experiments." Hungarian Medical Journal 2, no. 2 (2008): 279–91. http://dx.doi.org/10.1556/hmj.2.2008.2.28358.

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28

Schaeck, Marlien, Wim Van den Broeck, Katleen Hermans, and Annemie Decostere. "Fish as Research Tools: Alternatives to In Vivo Experiments." Alternatives to Laboratory Animals 41, no. 3 (2013): 219–29. http://dx.doi.org/10.1177/026119291304100305.

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29

Kilkenny, Carol, William Browne, Innes C. Cuthill, Michael Emerson, and Douglas G. Altman. "Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines." Journal of Cerebral Blood Flow & Metabolism 31, no. 4 (2011): 991–93. http://dx.doi.org/10.1038/jcbfm.2010.220.

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30

Kilkenny, Carol, William Browne, Innes C. Cuthill, Michael Emerson, and Douglas G. Altman. "Animal research: Reporting in vivo experiments: The ARRIVE guidelines." British Journal of Pharmacology 160, no. 7 (2010): 1577–79. http://dx.doi.org/10.1111/j.1476-5381.2010.00872.x.

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31

Kilkenny, Carol, William Browne, Innes C. Cuthill, Michael Emerson, and Douglas G. Altman. "Animal Research: Reporting In Vivo Experiments: The ARRIVE Guidelines." Journal of Gene Medicine 12, no. 7 (2010): 561–63. http://dx.doi.org/10.1002/jgm.1473.

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32

N. I., Gelevera, Polukonova N. V., Baitman T. N., et al. "Investigation of the activity of the flavonoid-containing Chamerion angustifolium extract in the experiments in vitro and in vivo." Bulletin of Botanic Garden of Saratov State University 15, no. 4 (2017): 3–15. http://dx.doi.org/10.18500/1682-1637-2017-15-4-3-15.

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33

Li, Guo-Yang, Qiong He, Lin-Xue Qian, et al. "Elastic Cherenkov effects in transversely isotropic soft materials-II: Ex vivo and in vivo experiments." Journal of the Mechanics and Physics of Solids 94 (September 2016): 181–90. http://dx.doi.org/10.1016/j.jmps.2016.04.028.

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34

Popov, B. V., A. M. Zaichik, M. B. Budko, et al. "Epithelial cells transdifferentiation into bladder urothelium in experiments in vivo." Cell and Tissue Biology 5, no. 4 (2011): 358–65. http://dx.doi.org/10.1134/s1990519x11040079.

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35

Van der Zee, D. C., Chr Vermeij-Keers, and A. E. Smitsvan Prooije. "A new technique for in vivo experiments in rat embryos." Cell Differentiation and Development 27 (August 1989): 102. http://dx.doi.org/10.1016/0922-3371(89)90333-x.

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36

Garcia, Pio. "Computer simulations and experiments: in vivo–in vitro conditions in biochemistry." Foundations of Chemistry 17, no. 1 (2015): 49–65. http://dx.doi.org/10.1007/s10698-015-9215-2.

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37

Verhagen, H. J. M., J. D. Blankensteijn, Ph G. de Groot, et al. "In Vivo experiments with mesothelial cell seeded ePTFE vascular grafts." European Journal of Vascular and Endovascular Surgery 15, no. 6 (1998): 489–96. http://dx.doi.org/10.1016/s1078-5884(98)80108-1.

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38

Hothorn, Ludwig A. "Statistical Analysis of in Vivo Anticancer Experiments: Tumor Growth Inhibition." Drug Information Journal 40, no. 2 (2006): 229–38. http://dx.doi.org/10.1177/009286150604000212.

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39

TANAKA, Takuya, Masatoshi SUZUKI, Tetsuya NISHIMOTO, Yasuhiro MATUI, and Yuichiro SAKAMOTO. "3A12 Study of abdominal injury criterion by in vivo experiments." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2013.25 (2013): 485–86. http://dx.doi.org/10.1299/jsmebio.2013.25.485.

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40

Reinhardt, T., A. Bitz, A. El Ouardi, et al. "Exposure set-ups for in vivo experiments using radial waveguides." Radiation Protection Dosimetry 124, no. 1 (2007): 21–26. http://dx.doi.org/10.1093/rpd/ncm370.

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41

Hanton, D. Y., H. Furtak, and H. G. Grimm. "Preparation and Handling Conditions of MMVF for In-Vivo Experiments." Aerosol Science and Technology 29, no. 5 (1998): 449–56. http://dx.doi.org/10.1080/02786829808965583.

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42

Mukerjea, Romila, Rupendra Mukerjea, and John F. Robyt. "Starch biosynthesis: experiments on how starch granules grow in vivo." Carbohydrate Research 344, no. 1 (2009): 67–73. http://dx.doi.org/10.1016/j.carres.2008.09.022.

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43

Dwarkasing⁎, J., J. Meijerink, R. Witkamp, and K. van Norren. "Factors contributing to reproducibility of in vivo experiments on endocannabinoids." European Journal of Pharmacology 668 (September 2011): e45. http://dx.doi.org/10.1016/j.ejphar.2011.09.302.

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44

Lipatov, Vyacheslav A., Aleksey A. Kryukov, Dmitry A. Severinov, and Araik R. Saakyan. "Ethical and legal aspects of in vivo experimental biomedical research." I.P. Pavlov Russian Medical Biological Herald 27, no. 1 (2019): 80–92. http://dx.doi.org/10.23888/pavlovj201927180-92.

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In XXI century in vivo experiments came into a common use in connection with development of biological and medical scientific fields. In the first part of the work historical and techni-cal aspects of use of animals in in vivo experiments are considered. In the work the problem of choice of a kind of laboratory animal for experimental purposes is discussed, and also the number of animals in the experimental groups is substantiated for further statistical processing of the primary information and determination of the reliability of differences in interpretation of the obtained results. According to the data of analyzed literature sources, modern researchers keep to the non-violence strategy and ahimsa principle (from Lat. ahimsᾱ causing no harm). Here, the dominating point of view is the necessity for in vivo experiments for further development of the biomedical science. This is possible provided suffering of animals are minimized with their minimal number in an experiment. The choice of the animal species first of all depends on the task faced by an experimenter. Besides, in each research a thorough choice of a specific animal is required based on the information of its health, maintenance and feeding, anatomical and physiological peculiarities, age, genetic characteristics. Chronic and acute surgical experiments are usually conducted on large vertebrate animals: dogs, European rabbits, house cats, while the action and effectiveness of pharmacological drugs are more conveniently studied on small laboratory animals: house mice, common rats, guinea-pigs, golden hamsters.
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45

Vásquez, Juan Luis, Per Ibsen, Henriette Lindberg, and Julie Gehl. "In Vitro and In Vivo Experiments on Electrochemotherapy for Bladder Cancer." Journal of Urology 193, no. 3 (2015): 1009–15. http://dx.doi.org/10.1016/j.juro.2014.09.039.

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46

Ishiyama, Tadahiko, Shuji Dohi, Hiroki Iida, Yukinaga Watanabe, and Hiroyuki Shimonaka. "Mechanisms of Dexmedetomidine-Induced Cerebrovascular Effects in Canine In Vivo Experiments." Anesthesia & Analgesia 81, no. 6 (1995): 1208–15. http://dx.doi.org/10.1097/00000539-199512000-00016.

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47

Zhuravlev, Pavel I., Michael Hinczewski, Shaon Chakrabarti, Susan Marqusee, and D. Thirumalai. "Reply to Alberti: Are in vitro folding experiments relevant in vivo?" Proceedings of the National Academy of Sciences 113, no. 23 (2016): E3192. http://dx.doi.org/10.1073/pnas.1603395113.

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48

Druilhe, P., A. Sabchareon, H. Bouharoun-Tayoun, C. Oeuvray, and J. L. Perignon. "In vivo veritas: lessons from immunoglobulin-transfer experiments in malaria patients." Annals of Tropical Medicine & Parasitology 91, sup1 (1997): S37—S53. http://dx.doi.org/10.1080/00034983.1997.11813238.

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49

DRUILHE, P. "In vivo veritas : lessons from immunoglobulin transfer experiments in malaria patients." Annals of Tropical Medicine And Parasitology 91, no. 2 (1997): 37–54. http://dx.doi.org/10.1080/00034989761292.

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50

Piersma, F. E., M. A. R. C. Daemen, A. E. J. M. vd Bogaard, and W. A. Buurman. "Interference of pain control employing opioids in in vivo immunological experiments." Laboratory Animals 33, no. 4 (1999): 328–33. http://dx.doi.org/10.1258/002367799780487887.

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