Log in

Relevant bibliographies by topics / In vivo studies / Journal articles

To see the other types of publications on this topic, follow the link: In vivo studies.

Journal articles on the topic 'In vivo studies'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'In vivo studies.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Naveed, Safila, Najma Sultana, and Muhammad Saeed Arayne. "In vivo and in vitro interaction studies of ibuprofen with enalapril." Journal of Coastal Life Medicine 4, no. 4 (April 2016): 327–30. http://dx.doi.org/10.12980/jclm.4.2016j5-198.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Sharma, Rakesh Kumar, and Anil Kumar Midda. "Preparation of Sustained Release Microspheres of Aceclofenac: Characterization & in-vivo studies." International Journal of Research and Development in Pharmacy & Life Sciences 6, no. 7 (December 2017): 2862–66. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2017.6(7).2862-2866.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Herbold, Bernd A., Susanne Y. Brendler-Schwaab, and Hans Jürgen Ahr. "Ciprofloxacin: in vivo genotoxicity studies." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 498, no. 1-2 (November 2001): 193–205. http://dx.doi.org/10.1016/s1383-5718(01)00275-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Su, Muh-Hwan, V. Srinivasan, Abdel-Halim Ghanem, and William I. Higuchi. "Quantitative in Vivo Iontophoretic Studies." Journal of Pharmaceutical Sciences 83, no. 1 (January 1994): 12–17. http://dx.doi.org/10.1002/jps.2600830105.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Pomare, E. W., L. C. Hillman, S. Peters, and A. Fisher. "In vivo studies with fibre components." Scandinavian Journal of Gastroenterology 22, sup129 (January 1987): 181–84. http://dx.doi.org/10.3109/00365528709095881.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Booij, L. H. D. J., J. van Egmond, J. J. Driessen, and H. D. de Boer. "In vivo animal studies with sugammadex." Anaesthesia 64 (March 2009): 38–44. http://dx.doi.org/10.1111/j.1365-2044.2008.05869.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Fahmy, Maha A., and Kawthar A. E. Diab. "In vivo Genotoxicity Studies of Cefotaxime." CYTOLOGIA 74, no. 4 (2009): 417–25. http://dx.doi.org/10.1508/cytologia.74.417.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Kaufman, Herbert E. "IN VIVO STUDIES WITH ANTIVIRAL AGENTS*." Annals of the New York Academy of Sciences 130, no. 1 (December 16, 2006): 168–80. http://dx.doi.org/10.1111/j.1749-6632.1965.tb12550.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

DUFFY, S., P. C. REID, and F. SHARP. "In-vivo studies of uterine electrosurgery." BJOG: An International Journal of Obstetrics and Gynaecology 99, no. 7 (July 1992): 579–82. http://dx.doi.org/10.1111/j.1471-0528.1992.tb13824.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Nikitin, Alexander, Yi Wang, and Emmanuel Giannelis. "In vivo toxicity studies of nanoparticles." Toxicology Letters 180 (October 2008): S222. http://dx.doi.org/10.1016/j.toxlet.2008.06.094.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Iverson, F. "In vivo studies on butylated hydroxyanisole." Food and Chemical Toxicology 37, no. 9-10 (September 1999): 993–97. http://dx.doi.org/10.1016/s0278-6915(99)00091-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Akhtar, Saghir, and Sudhir Agrawal. "In vivo studies with antisense oligonucleotides." Trends in Pharmacological Sciences 18, no. 1 (January 1997): 12–18. http://dx.doi.org/10.1016/s0165-6147(96)01002-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Wosu, L. O. "Feline panleucopenia — In vivo infectivity studies." Veterinary Microbiology 16, no. 2 (February 1988): 137–43. http://dx.doi.org/10.1016/0378-1135(88)90038-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Heyman, P. W., C. S. Cho, J. C. McRea, D. B. Olsen, and S. W. Kim. "Heparinized polyurethanes:In vitro andin vivo studies." Journal of Biomedical Materials Research 19, no. 4 (April 1985): 419–36. http://dx.doi.org/10.1002/jbm.820190407.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Rudnev, Sergey G. "11th International Symposium on In Vivo Body Composition Studies." Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), no. 4 (April 17, 2019): 139–45. http://dx.doi.org/10.32521/2074-8132.2018.4.139-145.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Mitrofanov, V. N., O. P. Zhivtsov, N. Yu Orlinskaya, and D. V. Davydenko. "Experimental model of chronic focal osteomyelitis for in vivo studies." CLINICAL AND EXPERIMENTAL MORPHOLOGY 10, no. 1 (2021): 71–77. http://dx.doi.org/10.31088/cem2021.10.1.71-77.

Full text

Abstract:

Introduction. The article describes an experimental model of chronic suppurative osteomyelitis in a rabbit. As new therapeutic and diagnostic algorithms for the supervision of patients with osteomyelitis appear, there is an growing need to compare the methods of surgical debridement and plasty of bone defects in an infectious process, in order to create experimental standardized pathological conditions as close to the clinical course of the disease in humans as possible. The aim of the study was to develop an experimental model of a standardized chronic purulent bone cavity, suitable for a comprehensive assessment of surgical debridement effectiveness and osteoplastic properties of bone substitute materials. Materials and methods. A standardized defect of the tibia in 24 rabbits was formed. The Staphylococcusaureus strain was used as an infectious agent. A dynamic assessment of the main indicators of blood counts in animals was carried out. The formation of chronic osteomyelitis was evaluated using radiography, com-puted tomography methods and histological studies. Results. It was shown that purulent bone wound developed in experimental animals with the technique cre-ated, and a defect with signs of a chronic purulent-inflammatory process was demonstrated. Conclusion. The proposed model of chronic osteomyelitis is reproducible. Operational flexibility and identi-cal in size and location bone defects allow to use this model in new osteoplastic material research. Keywords: chronic osteomyelitis, experiment, experimental animals

APA, Harvard, Vancouver, ISO, and other styles

17

Fusco, Roberta, Giacomo Perazzolo Gallo, Elio Di Bernardo, Valeria D’Alessio, Mattia Ronchetti, Matteo Cadossi, and Ruggero Cadossi. "In Vivo and Ex Vivo Gene Electrotransfer in Ophthalmological Disorders." Biomedicines 10, no. 8 (August 4, 2022): 1889. http://dx.doi.org/10.3390/biomedicines10081889.

Full text

Abstract:

The aim of this document is to present an overview of gene electrotransfer in ophthalmological disorders. In order to ensure an adequate variety of the assessed studies, several electronic databases were considered and studies published between January 1998 and December 2021 were analysed. Three investigators carried out data extraction and analysis, focusing on both technical (i.e., electrical protocol, type of electrode, plasmid) and medical (i.e., type of study, threated disease) aspects and highlighting the main differences in terms of results obtained. Moreover, the IGEA experience in the project “Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration” (TargetAMD) was reported in the results section. No clinical trial was found on international literature and on clinicaltrial.gov. Twelve preclinical studies were found including in vivo and ex-vivo applications. The studied showed that electrotransfer could be very efficient for plasmid DNA transfection. Many attempts such as modification of the electric field, buffers and electrodes have been made and the optimization of electric field setting seems to be very important. Using this technique, gene replacement can be designed in cases of retinal inheritance or corneal disease and a wide range of human eye diseases could, in the future, benefitfrom these gene therapy technologies.

APA, Harvard, Vancouver, ISO, and other styles

18

Rivas, Lourdes, Samuel Dulay, Sandrine Miserere, Laura Pla, Sergio Berdún Marin, Johanna Parra, Elisenda Eixarch, et al. "Micro-needle implantable electrochemical oxygen sensor: ex-vivo and in-vivo studies." Biosensors and Bioelectronics 153 (April 2020): 112028. http://dx.doi.org/10.1016/j.bios.2020.112028.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Babayeva, Mariana, Susan Cox, Michael P. White, and David R. Taft. "Renal excretion of apricitabine in rats: ex vivo and in vivo studies." European Journal of Drug Metabolism and Pharmacokinetics 36, no. 3 (April 6, 2011): 141–50. http://dx.doi.org/10.1007/s13318-011-0038-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Bauer, Thomas-A. "Vivo, ergo sum-sanus: communication studies facing Health as a construction of social knowledge." Comunicar 13, no. 26 (March 1, 2006): 43–50. http://dx.doi.org/10.3916/c26-2006-07.

Full text

Abstract:

A constructive theoretical view of everyday topics (in this paper context, we mean health) allows us to spot on communication models and cultural features of important daily aspects. This paper holds health up as a model of knowledge inside cultural programme fields. By drawing on this theoretical and scientist communication context, the relationship between health and its development can be shown as a pattern of life, taking always into consideration social conditions. Aunque la mayoría de los científicos compartan hoy el supuesto de que las ideas de salud y enfermedad son construcciones sociales relativas a estados físicos, psíquicos o sociales, sin embargo, todavía se mantienen planteamientos teóricos que, equivocadamente, conciben la salud o la enfermedad en relación con la comunicación. Este artículo busca fijar ambos conceptos –salud y enfermedad– en el marco de los estudios culturales, con la ayuda de la teoría de la observación y con referencias a una teoría sistémica constructivista.

APA, Harvard, Vancouver, ISO, and other styles

21

Zhang, Yanling, Chin-Ping Kung, Fotis Iliopoulos, Bruno C. Sil, Jonathan Hadgraft, and Majella E. Lane. "Dermal Delivery of Niacinamide—In Vivo Studies." Pharmaceutics 13, no. 5 (May 14, 2021): 726. http://dx.doi.org/10.3390/pharmaceutics13050726.

Full text

Abstract:

In vivo human studies are considered to be the “gold standard” when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell studies. In the present work, dermal delivery of NIA was investigated in vivo in human subjects using confocal Raman spectroscopy (CRS) and tape stripping (TS). The vehicles investigated included propylene glycol (PG), Transcutol® P (TC), binary combinations of PG with oleic acid (OA) or linolenic acid (LA) and a ternary system comprising of TC, caprylic/capric triglyceride (CCT) and dimethyl isosorbide (DMI). For the CRS studies, higher area under curve (AUC) values for NIA were observed for the PG:LA binary system compared with PG, TC and TC:CCT:DMI (p < 0.05). A very good correlation was found between the in vitro cumulative permeation of NIA and the AUC values from Raman intensity depth profiles, with a Pearson correlation coefficient (R2) of 0.84. In addition, an excellent correlation (R2 = 0.97) was evident for the signal of the solvent PG and the active. CRS was also shown to discriminate between NIA in solution versus crystalline NIA. The findings confirm that CRS is emerging as a powerful approach for dermatopharmacokinetic studies of both actives and excipients in human.

APA, Harvard, Vancouver, ISO, and other styles

22

Bulte, Jeff W. M. "In Vivo MRI Cell Tracking: Clinical Studies." American Journal of Roentgenology 193, no. 2 (August 2009): 314–25. http://dx.doi.org/10.2214/ajr.09.3107.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

METZGER, K., H. ZEILER, and K. GROHE. "Ciprofloxacin: studies in vitro and in vivo." Biochemical Society Transactions 14, no. 2 (April 1, 1986): 507. http://dx.doi.org/10.1042/bst0140507a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Wang, Ge, Wenxiang Cong, Kumar Durairaj, Xin Qian, Haiou Shen, Patrick Sinn, Eric Hoffman, Geoffrey McLennan, and Michael Henry. "In vivo mouse studies with bioluminescence tomography." Optics Express 14, no. 17 (2006): 7801. http://dx.doi.org/10.1364/oe.14.007801.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Nair, Jerald J., Jaume Bastida, and Johannes van Staden. "In Vivo Cytotoxicity Studies of Amaryllidaceae Alkaloids." Natural Product Communications 11, no. 1 (January 2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100134.

Full text

Abstract:

The plant family Amaryllidaceae is recognizable for its esthetic floral characteristics, its widespread usage in traditional medicine as well as its unique alkaloid principles. Few alkaloid-producing families rival the Amaryllidaceae in terms of the diversity of its structures as well as their wide applicability on the biological landscape. In particular, cytotoxic effects have come to be a dominant theme in the biological properties of Amaryllidaceae alkaloids. To this extent, a significant number of structures have been subjected to in vitro studies in numerous cell lines from which several targets have been identified as promising chemotherapeutics. By contrast, in vivo models of study involving these alkaloids have been carried out to a lesser extent and should prove crucial in the continued development of a clinical target such as pancratistatin. This survey examines the cytotoxic effects of Amaryllidaceae alkaloids in vivo and contrasts these against the corresponding in vitro effects.

APA, Harvard, Vancouver, ISO, and other styles

26

Fontaine, Arthur B., and Susan Dos Passos. "Vascular Stent Prototype: In Vivo Swine Studies." Journal of Vascular and Interventional Radiology 8, no. 1 (January 1997): 107–11. http://dx.doi.org/10.1016/s1051-0443(97)70524-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Broglio, Fabio, Silvia Grottoli, Emanuela Arvat, and Ezio Ghigo. "Endocrine actions of cortistatin: In vivo studies." Molecular and Cellular Endocrinology 286, no. 1-2 (May 2008): 123–27. http://dx.doi.org/10.1016/j.mce.2007.12.012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Luo, Xuechun, Yufeng Jiang, and Riqing Zhang. "In vivo dynamic studies of brain metabolism." Tsinghua Science and Technology 10, no. 4 (August 2005): 496–98. http://dx.doi.org/10.1016/s1007-0214(05)70106-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Comment, Arnaud. "Dissolution DNP for in vivo preclinical studies." Journal of Magnetic Resonance 264 (March 2016): 39–48. http://dx.doi.org/10.1016/j.jmr.2015.12.027.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Eckelman, William C. "Radiolabeled muscarinic radioligands for in vivo studies." Nuclear Medicine and Biology 28, no. 5 (July 2001): 485–91. http://dx.doi.org/10.1016/s0969-8051(01)00217-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Meehan, A. G., D. L. Kreulen, P. C. Johnson, B. Liu, G. D. S. Hirst, and T. C. Cunnane. "Electrophysiological studies on mesenteric arterioles in vivo." Journal of the Autonomic Nervous System 33, no. 2 (May 1991): 180–81. http://dx.doi.org/10.1016/0165-1838(91)90197-b.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Abercrombie, E. D. "Stress and brain norepinephrine:in vivo dialysis studies." Biological Psychiatry 35, no. 9 (May 1994): 710. http://dx.doi.org/10.1016/0006-3223(94)90999-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Sarre, S., D. Deleu, K. Van Belle, G. Ebinger, and Y. Michotte. "In-vivo microdialysis sampling in pharmacokinetic studies." TrAC Trends in Analytical Chemistry 12, no. 2 (February 1993): 67–73. http://dx.doi.org/10.1016/0165-9936(93)87053-z.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Lewis, James F. "In Vivo Studies of Aerosolized Exogenous Surfactant." Aerosol Science and Technology 22, no. 4 (January 1995): 354–63. http://dx.doi.org/10.1080/02786829408959753.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Corongiu, Francesco P., Silvana Vargiolu, Anna Milia, Kevin H. Cheeseman, and Trevor F. Slater. "Antioxidants and lipid peroxidation: “In vivo” studies." Biochemical Pharmacology 34, no. 3 (February 1985): 397–98. http://dx.doi.org/10.1016/0006-2952(85)90057-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Oberdürster, Güunter. "Toxicology of ultrafine particles: in vivo studies." Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences 358, no. 1775 (October 15, 2000): 2719–40. http://dx.doi.org/10.1098/rsta.2000.0680.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Cairns, P., V. J. Morris, R. L. Botham, and S. G. Ring. "Physicochemical Studies on Resistant StarchIn VitroandIn Vivo." Journal of Cereal Science 23, no. 3 (May 1996): 265–75. http://dx.doi.org/10.1006/jcrs.1996.0027.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Lee, Michael K., Dike Qiu, Christian Lesuisse, Paul Hoffman, Wanda Sterling, and Donald L. Price. "Synucleins: In vitro and in vivo studies." Neurobiology of Aging 21 (May 2000): 284. http://dx.doi.org/10.1016/s0197-4580(00)83225-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Reddi, Elena. "Far-red absorbing photosensitizers: in vivo studies." Journal of Photochemistry and Photobiology B: Biology 9, no. 3-4 (June 1991): 395–96. http://dx.doi.org/10.1016/1011-1344(91)80191-j.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Cowan, Alan, and Debra E. Gmerek. "In-vivo studies on kappa opioid receptors." Trends in Pharmacological Sciences 7 (January 1986): 69–72. http://dx.doi.org/10.1016/0165-6147(86)90257-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Stokols, Daniel, Richard Harvey, Jennifer Gress, Juliana Fuqua, and Kimari Phillips. "In vivo studies of transdisciplinary scientific collaboration." American Journal of Preventive Medicine 28, no. 2 (February 2005): 202–13. http://dx.doi.org/10.1016/j.amepre.2004.10.016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Gäbel, Jakob, Caroline Shams Hakimi, Martin Westerberg, Vladimir Radulovic, and Anders Jeppsson. "Retransfusion of cardiotomy suction blood impairs haemostasis: Ex vivo and in vivo studies." Scandinavian Cardiovascular Journal 47, no. 6 (September 16, 2013): 368–76. http://dx.doi.org/10.3109/14017431.2013.838640.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Zhu, Hong, Irene E. Kochevar, Irmgard Behlau, Jie Zhao, Fenghua Wang, Yucheng Wang, Xiaodong Sun, Michael R. Hamblin, and Tianhong Dai. "Antimicrobial Blue Light Therapy for Infectious Keratitis: Ex Vivo and In Vivo Studies." Investigative Opthalmology & Visual Science 58, no. 1 (January 27, 2017): 586. http://dx.doi.org/10.1167/iovs.16-20272.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Jannesar, Kosar, Samin Abbaszadeh, Hassan Malekinejad, and Hamid Soraya. "Cardioprotective effects of memantine in myocardial ischemia: Ex vivo and in vivo studies." European Journal of Pharmacology 882 (September 2020): 173277. http://dx.doi.org/10.1016/j.ejphar.2020.173277.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

JOHNSSON, C., R. FESTIN, G. TUFVESON, and T. H. TÖTTERMAN. "Ex Vivo PKH26‐Labelling of Lymphocytes for Studies of Cell Migration In Vivo." Scandinavian Journal of Immunology 45, no. 5 (May 1997): 511–14. http://dx.doi.org/10.1046/j.1365-3083.1997.d01-430.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Legon’kova, O. A., A. V. Chupin, A. S. Ogannisian, A. V. Nikitina, V. V. Stafford, I. P. Savchenkova, A. B. Varava, S. V. Sapelkin, and S. V. Pozyabin. "In Vivo Studies of a Liquid Embolic Compound." Bulletin of Experimental Biology and Medicine 170, no. 3 (January 2021): 360–63. http://dx.doi.org/10.1007/s10517-021-05067-w.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Prieto, Luis I., Sara I. Graves, and Darren J. Baker. "Insights from In Vivo Studies of Cellular Senescence." Cells 9, no. 4 (April 13, 2020): 954. http://dx.doi.org/10.3390/cells9040954.

Full text

Abstract:

Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells remain metabolically active and often acquire a distinctive bioactive secretory phenotype. Much of our molecular understanding in senescent cell biology comes from studies using mammalian cell lines exposed to stress or extended culture periods. While less well understood mechanistically, senescence in vivo is becoming appreciated for its numerous biological implications, both in the context of beneficial processes, such as development, tumor suppression, and wound healing, and in detrimental conditions, where senescent cell accumulation has been shown to contribute to aging and age-related diseases. Importantly, clearance of senescent cells, through either genetic or pharmacological means, has been shown to not only extend the healthspan of prematurely and naturally aged mice but also attenuate pathology in mouse models of chronic disease. These observations have prompted an investigation of how and why senescent cells accumulate with aging and have renewed exploration into the characteristics of cellular senescence in vivo. Here, we highlight our molecular understanding of the dynamics that lead to a cellular arrest and how various effectors may explain the consequences of senescence in tissues. Lastly, we discuss how exploitation of strategies to eliminate senescent cells or their effects may have clinical utility.

APA, Harvard, Vancouver, ISO, and other styles

48

Eremina, N. V., L. G. Kolik, R. U. Ostrovskaya, and A. D. Durnev. "Preclinical in vivo Neurotoxicity Studies of Drug Candidates." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 10, no. 3 (September 18, 2020): 164–76. http://dx.doi.org/10.30895/1991-2919-2020-10-3-164-176.

Full text

Abstract:

Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity. Current experimental approaches to neurotoxicity assessment are cumbersome, laborious and not adapted enough for preclinical studies in the early stages of drug development. The aim of the study was to review existing approaches to experimental assessment of neurotoxic potential of new drugs and to discuss the need for and feasibility of developing and using integrated rapid neurotoxicity tests for early assessment of a pharmacological project’s potential. The authors reviewed scientific literature and guidance documents and analysed current approaches to chemical compound neurotoxicity assessment in laboratory animals. The paper analyses the main issues of neurotoxicity assessment for new drugs and compares Irwin tests with the functional observation battery. It analyses issues related to assessment of drugs’ effects on the development and maturation of central nervous system functions at pre- and postnatal stages. It was determined that the current practice is not sufficient for assessment of potential adverse effects on cognitive functions. The authors assessed factors affecting cognitive functions of rodents during studies. The “Acute suppression of the exploratory and orientation response” and “Extrapolation escape task” tests were proposed for validation as potential rapid tests for detection of an array of organic and functional neurotoxic disorders at early stages of preclinical studies.

APA, Harvard, Vancouver, ISO, and other styles

49

M. Abrantes, A., E. Serra, C. Goncalves, B. Oliveiros, M. Laranjo, A. B. Sarmento-Ribeiro, A. Rocha-Gonsalves, and M. F. Botelho. "Tumour Hypoxia and Technetium Tracers: In Vivo Studies." Current Radiopharmaceuticalse 5, no. 2 (April 1, 2012): 99–105. http://dx.doi.org/10.2174/1874471011205020099.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Law, A., G. W. Jack, M. Tellez, and C. J. Edmonds. "In-vivo studies of a human-thyrotrophin preparation." Journal of Endocrinology 110, no. 2 (August 1986): 375–78. http://dx.doi.org/10.1677/joe.0.1100375.

Full text

Abstract:

ABSTRACT The effects on thyroid function of a new preparation of human thyrotrophin (hTSH) were studied in four subjects whose endogenous production of TSH had been suppressed by administration of thyroxine (T4). The hTSH, prepared from human cadaveric pituitary glands and highly purified using a monoclonal antibody technique, was given as an intravenous bolus of 2 i.u. hTSH. Serum TSH levels rose rapidly to a maximum of about 150 mu./l and then declined exponentially with a half-life of 100 min. After injection, the hTSH distributed rapidly in a volume averaging about 13 litres which corresponded approximately to the expected extracellular fluid volume of the subjects. Serum free tri-iodothyronine and free T4 rose significantly, reaching a maximum between 4 and 8 h after injection of hTSH; serum thyroglobulin was not altered significantly. The rise of thyroid pertechnetate uptake, a measure of the thyroid iodide uptake, occurred later, being only slightly increased at 8 h after administration of hTSH and reaching a maximum at 24 h. J. Endocr. (1986) 110, 375–378

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!