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Journal articles on the topic 'IN01'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Kwon, S. U. "IN01-MO-03 Medical management of intracranial atherosclerosis." Journal of the Neurological Sciences 285 (October 2009): S5. http://dx.doi.org/10.1016/s0022-510x(09)70032-2.

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GAVUROVA, Beata, Miroslava PACKOVA, Maria MISANKOVA, and Lubos SMRCKA. "PREDICTIVE POTENTIAL AND RISKS OF SELECTED BANKRUPTCY PREDICTION MODELS IN THE SLOVAK BUSINESS ENVIRONMENT." Journal of Business Economics and Management 18, no. 6 (2017): 1156–73. http://dx.doi.org/10.3846/16111699.2017.1400461.

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In our study, we focused on the assessment of four bankruptcy prediction models, to figure out which model is most appropriate in the conditions of the Slovak business environment. Based on the previous research within the Slovak conditions, we set a portfolio of 4 models to be assessed: Altman model (1984), Ohlson model (1980), indexes IN01 and IN05 that were validated on the sample of 700 Slovak companies. Based on previous studies we expected that IN indexes are superior to Ohlson and Altman model. The excellency of our research lies in validation and assessing the accuracy of bankruptcy pr

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3

Davis, S. M. "IN01-MO-02 The pathophysiology and diagnosis of ischemic stroke." Journal of the Neurological Sciences 285 (October 2009): S5. http://dx.doi.org/10.1016/s0022-510x(09)70031-0.

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4

Martínez-Pacheco, Heidy, Ofir Picazo, Adolfo López-Torres, et al. "Biochemical and Behavioral Characterization of IN14, a New Inhibitor of HDACs with Antidepressant-Like Properties." Biomolecules 10, no. 2 (2020): 299. http://dx.doi.org/10.3390/biom10020299.

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Evidence suggests that histone deacetylases (HDACs) inhibitors could be used as an effective treatment for some psychiatric and neurological conditions such as depression, anxiety and age-related cognitive decline. However, non-specific HDAC inhibiting compounds have a clear disadvantage regarding their efficacy and safety, thus the need to develop more selective ones. The present study evaluated the toxicity, the capacity to inhibit HDAC activity and antidepressant-like activity of three recently described class I HDAC inhibitors IN01, IN04 and IN14, using A. salina toxicity test, in vitro fl

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5

Rahmiati, Rahmiati, Helen Anjelina Simanjuntak, and Toberni S. Situmorang. "KEMAMPUAN BAKTERI ASAM LAKTAT DALAM MENGHAMBAT Salmonella thypii." Journal of Natural Sciences 1, no. 3 (2021): 143–51. http://dx.doi.org/10.34007/jns.v1i3.25.

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Lactic acid bacteria are known to have the ability to produce antimicrobial compounds known as bacteriocins. This study aims to determine the ability of lactic acid bacteria to inhibit the growth of Salmonella thypii bacteria. In this study, the lactic acid bacteria used were a collection of the Biology Laboratory of the University of Medan Area. Eight types of lactic acid bacterial isolates were used, including IN01, IN02, SF01, SF02, NN01, NN02 SPU01 and SPU04. A confirmation test was carried out on the growth of lactic acid bacteria and Salmonella thypii by visual and microcopic confirmatio

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6

Shen, Shi, Steven A. Niederer, Steven E. Williams, John Whitaker, Paul Bongiorni, and Stuart Campbell. "B-IN01-05 FUNCTIONAL EFFECTS OF GAMMA RADIATION ON HUMAN CARDIOMYOCYTES." Heart Rhythm 18, no. 8 (2021): S465—S466. http://dx.doi.org/10.1016/j.hrthm.2021.06.1148.

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7

Donnan, G. A. "IN01-MO-01 Penumbral selection for trials of therapy: ready or not?" Journal of the Neurological Sciences 285 (October 2009): S5. http://dx.doi.org/10.1016/s0022-510x(09)70030-9.

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8

Hájek, Petr, Gulnar Zhunissova, Taťjana Čábelová, and Adilya Baidildina. "COMPETITIVENESS ANALYSIS OF KAZAKHSTAN CONFECTIONARY SECTOR USING FINANCIAL DISCRIMINANT MODELS." CBU International Conference Proceedings 5 (September 22, 2017): 144–53. http://dx.doi.org/10.12955/cbup.v5.916.

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Measuring competitiveness offers hundreds of analytical options. We have chosen to analyze and compare companies of confectionery sector in Kazakhstan. We opted to use bankruptcy and creditworthiness models and compare competitiveness through the financial situation of main competitors on that market. Companies analyzed comprise of two Ukrainian companies (Konti and Roshen), Russian companies (Nestlé Russian branch serving also Central Asian markets and KDV - Yaskino) and three local corporations Rakhat, Bayan Sulu and Konfety Karagandy. Models used for analysis are Altman z-score model, Taffl

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9

Coleman, Robert. "IN01 LIVING WITH METASTATIC BONE DISEASE – THE POSITIVE IMPACT OF BONE-TARGETED TREATMENTS." Breast 24 (November 2015): S21. http://dx.doi.org/10.1016/s0960-9776(15)30014-x.

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Caldwell, Jessica, Eric I-Ju Lee, Lianguo Wang, and Crystal M. Ripplinger. "B-IN01-04 SPATIO-TEMPORAL CAMP SIGNALING AND ARRHYTHMIA IN THE INTACT HEART." Heart Rhythm 18, no. 8 (2021): S465. http://dx.doi.org/10.1016/j.hrthm.2021.06.1147.

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11

Moore, Oliver, Jayso'n Davidson, Juwan Copeland, et al. "B-IN01-09 MULTIPLEX GENOME EDITING FOR THE TREATMENT OF CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA." Heart Rhythm 18, no. 8 (2021): S467. http://dx.doi.org/10.1016/j.hrthm.2021.06.1152.

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12

Monaci, Sofia, Karli Gillette, Esther Puyol-Antón, et al. "B-IN01-01 AUTOMATED LOCALISATION OF FOCAL VT ORIGINS USING IMPLANTED DEVICE EGMS AND CONVOLUTIONAL NEURAL NETWORKS." Heart Rhythm 18, no. 8 (2021): S464. http://dx.doi.org/10.1016/j.hrthm.2021.06.1144.

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13

Melman, Yonathan F., Paul Melman, Henry D. Huang, Meir Brosh, and Timothy Larsen. "B-IN01-03 FOCUSED ELECTRIC FIELD ABLATION: A NOVEL ABLATION TECHNOLOGY INCREASES ABLATION LESION DEPTH WITH IMPROVED SAFETY." Heart Rhythm 18, no. 8 (2021): S465. http://dx.doi.org/10.1016/j.hrthm.2021.06.1146.

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14

Deshmukh, Amrish, Mary A. Romanyshyn, Timothy Bechtol, Amlish Gondal, and Pramod M. Deshmukh. "B-IN01-02 DEEP SEPTAL PACING WITH RAPID LEFT VENTRICULAR ACTIVATION: A SIMPLIFIED APPROACH WITHOUT CONDUCTION SYSTEM TARGETING." Heart Rhythm 18, no. 8 (2021): S464—S465. http://dx.doi.org/10.1016/j.hrthm.2021.06.1145.

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15

Magtibay, Karl, Stephane Masse, Ahmed Niri, D. Curtis Deno, and Kumaraswamy Nanthakumar. "B-IN01-08 LOCAL ABNORMAL VENTRICULAR ACTIVITY REVEALS CONDUCTION PROPERTY DIFFERENT TO SYSTOLIC ACTIVATION DIRECTION USING OMNIPOLAR METHODOLOGY: LAVA FLOW." Heart Rhythm 18, no. 8 (2021): S467. http://dx.doi.org/10.1016/j.hrthm.2021.06.1151.

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Au, Chi Kin, Yat Sun Joseph Chan, and Bryan P. Yan. "B-IN01-06 PERSONALIZED APPROACH FOR CARDIAC RESYNCHRONIZATION THERAPY (CRT) IMPLANTATION GUIDED BY REAL-TIME NON-INVASIVE 3D ELECTROCARDIOGRAPHIC MAPPING." Heart Rhythm 18, no. 8 (2021): S466. http://dx.doi.org/10.1016/j.hrthm.2021.06.1149.

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17

Viberg, Fredrik, Tove Hygrell, Erik Dahlberg, et al. "B-IN01-07 AN ARTIFICIAL INTELLIGENCE-BASED MODEL FOR PREDICTION OF ATRIAL FIBRILLATION FROM SINGLE-LEAD SINUS RHYTHM ECGS ENABLING SCREENING." Heart Rhythm 18, no. 8 (2021): S466. http://dx.doi.org/10.1016/j.hrthm.2021.06.1150.

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18

Pertel, Monica, José Paulo Soares de Azevedo, and Isaac Volschan Junior. "Uso de indicadores de perdas para seleção de um benchmarking entre as companhias estaduais de serviço de distribuição de água no Brasil." Engenharia Sanitaria e Ambiental 21, no. 1 (2016): 159–68. http://dx.doi.org/10.1590/s1413-41520201600100120418.

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RESUMO Tendo como referência indicadores operacionais relacionados a perdas de água e que constam na base de dados do Sistema Nacional de Informações sobre Saneamento (SNIS), baseados em resultados do ano de 2010, o presente estudo definiu critérios para o estabelecimento de parâmetros de avaliação de desempenho operacional - benchmarking , e como estudo de caso utilizou dados referentes a 22 prestadores regionais de serviços de saneamento no Brasil, notadamente as companhias estaduais de saneamento. Complementarmente, a partir do agrupamento dos prestadores de serviços em função do atendiment

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19

Nikawa, Jun-ichi, Akiko Murakami, Etsuko Esumi, and Kohei Hosaka. "Cloning and Sequence of the SCS2 Gene, Which Can Suppress the Defect of IN01 Expression in an Inositol Auxotrophic Mutant of Saccharomyces cerevisiae1." Journal of Biochemistry 118, no. 1 (1995): 39–45. http://dx.doi.org/10.1093/oxfordjournals.jbchem.a124889.

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20

Ashburner, B. P., and J. M. Lopes. "Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes." Molecular and Cellular Biology 15, no. 3 (1995): 1709–15. http://dx.doi.org/10.1128/mcb.15.3.1709.

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In the yeast Saccharomyces cerevisiae, the phospholipid biosynthetic genes are highly regulated at the transcriptional level in response to the phospholipid precursors inositol and choline. In the absence of inositol and choline (derepressing), the products of the INO2 and INO4 genes form a heteromeric complex which binds to a 10-bp element, upstream activation sequence INO (UASINO), in the promoters of the phospholipid biosynthetic genes to activate their transcription. In the presence of inositol and choline (repressing), the product of the OPI1 gene represses transcription dictated by the U

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21

Bazdyrev, Evgeny, Polina Rusina, Maria Panova, Fedor Novikov, Ivan Grishagin, and Vladimir Nebolsin. "Lung Fibrosis after COVID-19: Treatment Prospects." Pharmaceuticals 14, no. 8 (2021): 807. http://dx.doi.org/10.3390/ph14080807.

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At the end of 2019, a highly contagious infection began its ominous conquest of the world. It was soon discovered that the disease was caused by a novel coronavirus designated as SARS-CoV-2, and the disease was thus abbreviated to COVID-19 (COVID). The global medical community has directed its efforts not only to find effective therapies against the deadly pathogen but also to combat the concomitant complications. Two of the most common respiratory manifestations of COVID are a significant reduction in the diffusing capacity of the lungs (DLCO) and the associated pulmonary interstitial damage.

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22

Ahn, Sejin, Dan Spatt, and Fred Winston. "The Schizosaccharomyces pombe inv1 + Regulatory Region Is Unusually Large and Contains Redundant cis -Acting Elements That Function in a SAGA- and Swi/Snf-Dependent Fashion." Eukaryotic Cell 11, no. 8 (2012): 1067–74. http://dx.doi.org/10.1128/ec.00141-12.

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ABSTRACT The Schizosaccharomyces pombe inv1 + gene encodes invertase, the enzyme required for hydrolysis of sucrose and raffinose. Transcription of inv1 + is regulated by glucose levels, with transcription tightly repressed in high glucose and strongly induced in low glucose. To understand this regulation, we have analyzed the inv1 + cis -regulatory region and the requirement for the trans -acting coactivators SAGA and Swi/Snf. Surprisingly, deletion of the entire 1-kilobase intergenic region between the inv1 + TATA element and the upstream open reading frame SPCC191.10 does not significantly

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23

La Porte, Annalena, Jennifer Cano, Xuhong Wu, Doyel Mitra, and Ganjam V. Kalpana. "An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability." Journal of Virology 90, no. 21 (2016): 9889–904. http://dx.doi.org/10.1128/jvi.00323-16.

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ABSTRACTINI1/hSNF5/SMARCB1/BAF47 is an HIV-specific integrase (IN)-binding protein that influences HIV-1 transcription and particle production. INI1 binds to SAP18 (Sin3a-associated protein, 18 kDa), and both INI1 and SAP18 are incorporated into HIV-1 virions. To determine the significance of INI1 and the INI1-SAP18 interaction during HIV-1 replication, we isolated a panel ofSAP18-interaction-defective (SID)-INI1 mutants using a yeast reverse two-hybrid screen. The SID-INI1 mutants, which retained the ability to bind to IN, cMYC, and INI1 but were impaired for binding to SAP18, were tested for

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24

Peterson, Jo Elle G., Abhishek Bavle, Vidya P. Mehta, et al. "Spontaneous Regression of Atypical Teratoid Rhabdoid Tumor Without Therapy in a Patient With Uncommon Regional Inactivation of SMARCB1 (hSNF5/INI1)." Pediatric and Developmental Pathology 22, no. 2 (2018): 161–65. http://dx.doi.org/10.1177/1093526618814696.

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Atypical teratoid/rhabdoid tumor (ATRT) is a high-grade central nervous system tumor, with poor prognosis despite intensive multimodal therapy. Loss of nuclear immunostaining for INI1 due to inactivation of the hSNF5/INI1 tumor suppressor gene is pathognomonic of ATRT. We present a patient with congenital ATRT, who had spontaneous tumor regression without therapy, and is disease-free 4 years later. Tumor histopathology showed rhabdoid cells characteristic of ATRT, but immunohistochemistry revealed heterogeneous loss of nuclear INI1 staining. The populations of INI1-intact and INI1-deficient ce

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25

Guidi, Cynthia J., Arthur T. Sands, Brian P. Zambrowicz, et al. "Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice." Molecular and Cellular Biology 21, no. 10 (2001): 3598–603. http://dx.doi.org/10.1128/mcb.21.10.3598-3603.2001.

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ABSTRACT SNF5/INI1 is a component of the ATP-dependent chromatin remodeling enzyme family SWI/SNF. Germ line mutations ofINI1 have been identified in children with brain and renal rhabdoid tumors, indicating that INI1 is a tumor suppressor. Here we report that disruption of Ini1 expression in mice results in early embryonic lethality. Ini1-null embryos die between 3.5 and 5.5 days postcoitum, and Ini1-null blastocysts fail to hatch, form the trophectoderm, or expand the inner cell mass when cultured in vitro. Furthermore, we report that approximately 15% ofIni1-heterozygous mice present with t

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Shetty, Ameet, and John M. Lopes. "Derepression of INO1 Transcription Requires Cooperation between the Ino2p-Ino4p Heterodimer and Cbf1p and Recruitment of the ISW2 Chromatin-Remodeling Complex." Eukaryotic Cell 9, no. 12 (2010): 1845–55. http://dx.doi.org/10.1128/ec.00144-10.

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ABSTRACT The Saccharomyces cerevisiae INO1 gene encodes the structural enzyme inositol-3-phosphate synthase for the synthesis de novo of inositol and inositol-containing phospholipids. The transcription of INO1 is completely derepressed in the absence of inositol and choline (I− C−). Derepression requires the binding of the Ino2p-Ino4p basic helix-loop-helix (bHLH) heterodimer to the UAS INO promoter element. We report here the requirement of a third bHLH protein, centromere-binding factor 1 (Cbf1p), for the complete derepression of INO1 transcription. We found that Cbf1p regulates INO1 transc

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Parker, Nathaniel A., Ammar Al-Obaidi, and Jeremy M. Deutsch. "SMARCB1/INI1-deficient tumors of adulthood." F1000Research 9 (June 30, 2020): 662. http://dx.doi.org/10.12688/f1000research.24808.1.

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The SMARCB1/INI1 gene was first discovered in the mid-1990’s, and since then it has been revealed that loss of function mutations in this gene result in aggressive rhabdoid tumors. Recently, the term “rhabdoid tumor” has become synonymous with decreased SMARCB1/INI1 expression. When genetic aberrations in the SMARCB1/INI1 gene occur, the result can cause reduced, complete loss, and mosaic expression. Although SMARCB1/INI1-deficient tumors are predominantly sarcomas, this is a diverse group of tumors with mixed phenotypes, which can often make the diagnosis challenging. Prognosis for these aggr

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28

Kamoun, Sophien, Theo van der Lee, Grardy van den Berg-Velthuis, Koen E. de Groot, and Francine Govers. "Loss of Production of the Elicitor Protein INF1 in the Clonal Lineage US-1 of Phytophthora infestans." Phytopathology® 88, no. 12 (1998): 1315–23. http://dx.doi.org/10.1094/phyto.1998.88.12.1315.

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The extracellular protein INF1 of Phytophthora infestans is a member of the elicitin family of protein elicitors known to induce a hypersensitive response on some solanaceous and cruciferous plants. The presence of INF1 elicitin in culture filtrates of 102 P. infestans isolates from 15 countries was examined. All tested isolates produced INF1 except five isolates collected in 1976 and 1977 from infected potatoes in East Germany (the former German Democratic Republic). Based on hybridization to the multi-locus DNA fingerprint probe RG57, all the INF1-nonproducing isolates were shown to belong t

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Kamoun, Sophien, Pieter van West, Anke J. de Jong, Koen E. de Groot, Vivianne G. A. A. Vleeshouwers, and Francine Govers. "A Gene Encoding a Protein Elicitor of Phytophthora infestans Is Down-Regulated During Infection of Potato." Molecular Plant-Microbe Interactions® 10, no. 1 (1997): 13–20. http://dx.doi.org/10.1094/mpmi.1997.10.1.13.

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Most species of the genus Phytophthora produce 10-kDa extracellular protein elicitors, collectively termed elicitins. Elicitins induce hypersensitive response in a restricted number of plants, particularly in the genus Nicotiana within the Solanaceae family. A cDNA encoding INF1, the major secreted elicitin of Phytophthora infestans, a pathogen of solanaceous plants, was isolated and characterized. The expression of the corresponding inf1 gene during the disease cycle of P. infestans was analyzed. inf1 was shown to be expressed in mycelium grown in various culture media, whereas it was not exp

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30

Taguwa, Shuhei, Toru Okamoto, Takayuki Abe, et al. "Human Butyrate-Induced Transcript 1 Interacts with Hepatitis C Virus NS5A and Regulates Viral Replication." Journal of Virology 82, no. 6 (2007): 2631–41. http://dx.doi.org/10.1128/jvi.02153-07.

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ABSTRACT Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is required for the replication of the viral genome and is involved in several host signaling pathways. To gain further insight into the functional role of NS5A in HCV replication, we screened human cDNA libraries by a yeast two-hybrid system using NS5A as the bait and identified human butyrate-induced transcript 1 (hB-ind1) as a novel NS5A-binding protein. Endogenously and exogenously expressed hB-ind1 was coimmunoprecipitated with NS5A of various genotypes through the coiled-coil domain of hB-ind1. The small interfering RNA (si

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31

Zhang, Zhi-Kai, Kelvin P. Davies, Jeffrey Allen, et al. "Cell Cycle Arrest and Repression of Cyclin D1 Transcription by INI1/hSNF5." Molecular and Cellular Biology 22, no. 16 (2002): 5975–88. http://dx.doi.org/10.1128/mcb.22.16.5975-5988.2002.

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ABSTRACT INI1/hSNF5 is a component of the ATP-dependent chromatin remodeling hSWI/SNF complex and a tumor suppressor gene of aggressive pediatric atypical teratoid and malignant rhabdoid tumors (AT/RT). To understand the molecular mechanisms underlying its tumor suppressor function, we studied the effect of reintroduction of INI1/hSNF5 into AT/RT-derived cell lines such as MON that carry biallelic deletions of the INI1/hSNF5 locus. We demonstrate that expression of INI1/hSNF5 causes G0-G1 arrest and flat cell formation in these cells. In addition, INI1/hSNF5 repressed transcription of cyclin D

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32

Frej, Anna D., Jonathan Clark, Caroline I. Le Roy, et al. "The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles." Molecular and Cellular Biology 36, no. 10 (2016): 1464–79. http://dx.doi.org/10.1128/mcb.00039-16.

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Inositol levels, maintained by the biosynthetic enzyme inositol-3-phosphate synthase (Ino1), are altered in a range of disorders, including bipolar disorder and Alzheimer's disease. To date, most inositol studies have focused on the molecular and cellular effects of inositol depletion without considering Ino1 levels. Here we employ a simple eukaryote,Dictyostelium discoideum, to demonstrate distinct effects of loss of Ino1 and inositol depletion. We show that loss of Ino1 results in an inositol auxotrophy that can be rescued only partially by exogenous inositol. Removal of inositol supplementa

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33

Parker, Nathaniel A., Ammar Al-Obaidi, and Jeremy M. Deutsch. "SMARCB1/INI1-deficient tumors of adulthood." F1000Research 9 (December 9, 2020): 662. http://dx.doi.org/10.12688/f1000research.24808.2.

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The SMARCB1/INI1 gene was first discovered in the mid-1990s, and since then it has been revealed that loss of function mutations in this gene result in aggressive rhabdoid tumors. Recently, the term “rhabdoid tumor” has become synonymous with decreased SMARCB1/INI1 expression. When genetic aberrations in the SMARCB1/INI1 gene occur, the result can cause complete loss of expression, decreased expression, and mosaic expression. Although SMARCB1/INI1-deficient tumors are predominantly sarcomas, this is a diverse group of tumors with mixed phenotypes, which can often make the diagnosis challenging

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34

Hirsch, J. P., and S. A. Henry. "Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis." Molecular and Cellular Biology 6, no. 10 (1986): 3320–28. http://dx.doi.org/10.1128/mcb.6.10.3320.

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The INO1 gene of Saccharomyces cerevisiae encodes the regulated enzyme inositol-1-phosphate synthase, which catalyzes the first committed step in the synthesis of inositol-containing phospholipids. The expression of this gene was analyzed under conditions known to regulate phospholipid synthesis. RNA blot hybridization with a genomic clone for INO1 detected two RNA species of 1.8 and 0.6 kb. The abundance of the 1.8-kb RNA was greatly decreased when the cells were grown in the presence of the phospholipid precursor inositol, as was the enzyme activity of the synthase. Complementation analysis

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35

Hirsch, J. P., and S. A. Henry. "Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis." Molecular and Cellular Biology 6, no. 10 (1986): 3320–28. http://dx.doi.org/10.1128/mcb.6.10.3320-3328.1986.

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The INO1 gene of Saccharomyces cerevisiae encodes the regulated enzyme inositol-1-phosphate synthase, which catalyzes the first committed step in the synthesis of inositol-containing phospholipids. The expression of this gene was analyzed under conditions known to regulate phospholipid synthesis. RNA blot hybridization with a genomic clone for INO1 detected two RNA species of 1.8 and 0.6 kb. The abundance of the 1.8-kb RNA was greatly decreased when the cells were grown in the presence of the phospholipid precursor inositol, as was the enzyme activity of the synthase. Complementation analysis

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36

Taguwa, Shuhei, Hiroto Kambara, Hiroko Omori, et al. "Cochaperone Activity of Human Butyrate-Induced Transcript 1 Facilitates Hepatitis C Virus Replication through an Hsp90-Dependent Pathway." Journal of Virology 83, no. 20 (2009): 10427–36. http://dx.doi.org/10.1128/jvi.01035-09.

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ABSTRACT Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a component of the replication complex consisting of several host and viral proteins. We have previously reported that human butyrate-induced transcript 1 (hB-ind1) recruits heat shock protein 90 (Hsp90) and FK506-binding protein 8 (FKBP8) to the replication complex through interaction with NS5A. To gain more insights into the biological functions of hB-ind1 in HCV replication, we assessed the potential cochaperone-like activity of hB-ind1, because it has significant homology with cochaperone p23, which regulates Hsp90 chapero

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37

Saito, A., T. Furukawa, S. Fukushige, et al. "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1." Journal of Human Genetics 45, no. 3 (2000): 177–81. http://dx.doi.org/10.1007/s100380050206.

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38

Graves, J. Anthony, and Susan A. Henry. "Regulation of the Yeast INO1 Gene: The Products of the INO2, INO4 and OPI1 Regulatory Genes Are Not Required for Repression in Response to Inositol." Genetics 154, no. 4 (2000): 1485–95. http://dx.doi.org/10.1093/genetics/154.4.1485.

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Abstract The ino2Δ, ino4Δ, opi1Δ, and sin3Δ mutations all affect expression of INO1, a structural gene for inositol-1-phosphate synthase. These same mutations affect other genes of phospholipid biosynthesis that, like INO1, contain the repeated element UASINO (consensus 5′ CATGTGAAAT 3′). In this study, we evaluated the effects of these four mutations, singly and in all possible combinations, on growth and expression of INO1. All strains carrying an ino2Δ or ino4Δ mutation, or both, failed to grow in medium lacking inositol. However, when grown in liquid culture in medium containing limiting a

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Young, Kevin G., Susan F. Thurston, Sarah Copeland, Chelsea Smallwood, and John W. Copeland. "INF1 Is a Novel Microtubule-associated Formin." Molecular Biology of the Cell 19, no. 12 (2008): 5168–80. http://dx.doi.org/10.1091/mbc.e08-05-0469.

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Formin proteins, characterized by the presence of conserved formin homology (FH) domains, play important roles in cytoskeletal regulation via their abilities to nucleate actin filament formation and to interact with multiple other proteins involved in cytoskeletal regulation. The C-terminal FH2 domain of formins is key for actin filament interactions and has been implicated in playing a role in interactions with microtubules. Inverted formin 1 (INF1) is unusual among the formin family in having the conserved FH1 and FH2 domains in its N-terminal half, with its C-terminal half being composed of

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Yung, Eric, Masha Sorin, Emilie-Jeanne Wang, Seena Perumal, David Ott, and Ganjam V. Kalpana. "Specificity of Interaction of INI1/hSNF5 with Retroviral Integrases and Its Functional Significance." Journal of Virology 78, no. 5 (2004): 2222–31. http://dx.doi.org/10.1128/jvi.78.5.2222-2231.2004.

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ABSTRACT Integrase interactor 1 (INI1)/hSNF5 is a host factor that directly interacts with human immunodeficiency virus type 1 (HIV-1) integrase and is incorporated into HIV-1 virions. Here, we show that while INI1/hSNF5 is completely absent from purified microvesicular fractions, it is specifically incorporated into HIV-1 virions with an integrase-to-INI1/hSNF5 stoichiometry of approximately 2:1 (molar ratio). In addition, we show that INI1/hSNF5 is not incorporated into related primate lentiviral and murine retroviral particles despite the abundance of the protein in producer cells. We have

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Nishihama, Ryuichi, Jennifer H. Schreiter, Masayuki Onishi, et al. "Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae." Journal of Cell Biology 185, no. 6 (2009): 995–1012. http://dx.doi.org/10.1083/jcb.200903125.

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Cytokinesis requires coordination of actomyosin ring (AMR) contraction with rearrangements of the plasma membrane and extracellular matrix. In Saccharomyces cerevisiae, new membrane, the chitin synthase Chs2 (which forms the primary septum [PS]), and the protein Inn1 are all delivered to the division site upon mitotic exit even when the AMR is absent. Inn1 is essential for PS formation but not for Chs2 localization. The Inn1 C-terminal region is necessary for localization, and distinct PXXP motifs in this region mediate functionally important interactions with SH3 domains in the cytokinesis pr

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Sali, Akash Pramod, Vishal Chaubey, Duhita Kodare, Ayushi Sahay, and Sridhar Epari. "The Rare Phenomenon of Loss of INI1 Expression at Recurrence/Progression of Primary Central Nervous System Tumors: Report of 3 Cases." International Journal of Surgical Pathology 28, no. 3 (2019): 341–47. http://dx.doi.org/10.1177/1066896919883942.

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It is extremely rare for loss of immunohistochemical expression of INI1 to occur primarily at recurrence/progression with retained expression at the primary/initial presentation of central nervous system (CNS) tumor. In this article, we present 3 such cases showing loss of INI1 expression primarily at recurrence. All patients were males, aged 7 years (case 1), 11 years (case 2), and 35 years (case 3), diagnosed with low-grade glial/glioneuronal tumor, not otherwise specified (case 1), craniopharyngioma (case 2), and glioblastoma (case 3); all showed retained INI1 protein expression. Case 1 at

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Rusu, Alexandra D., Zoe E. Cornhill, Brenda Canales Coutiño, et al. "CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity." Open Biology 11, no. 9 (2021): 210077. http://dx.doi.org/10.1098/rsob.210077.

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Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established roles in the transcriptional regulation of genes that control cell proliferation, response to DNA damage, oncogene-induced senescence and apoptosis. Recent work suggests a possible role for ING1 in cancer cell invasion and metastasis, but the molecular mechanism underlying this observation is lacking. Our results show that reduced expression of CG7379

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Barreto, Jhersyka Barros, Patrícia Hermínio Cunha Feitosa, Kainara Lira dos Anjos, and Wilton Maia Velez. "Análise da regionalização do saneamento: Cenários hídricos e (in)sustentabilidade econômico-financeira das microrregiões de água e esgoto da Paraíba." Research, Society and Development 10, no. 10 (2021): e117101018513. http://dx.doi.org/10.33448/rsd-v10i10.18513.

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No dia 15 de julho de 2020, foi publicada a Lei Federal nº 14.026, que altera um conjunto de leis relacionadas ao saneamento. Essa Lei estabeleceu um prazo de um ano para que os Estados criassem uma estrutura de regionalização do saneamento, especificamente dos serviços de água e esgoto. Se os Estados não implantarem as Microrregiões de Água e Esgoto no prazo estabelecido, a regionalização do saneamento, será estabelecida de forma compulsória pela União, com a criação de blocos de referência. A Paraíba, por meio da Lei Complementar nº 168 (2021), criou quatro microrregiões: Alto Piranhas, Borb

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Gong, Wei, Michael Russell, Keiko Suzuki, and Karl Riabowol. "Subcellular Targeting of p33ING1b by Phosphorylation-Dependent 14-3-3 Binding Regulates p21WAF1 Expression." Molecular and Cellular Biology 26, no. 8 (2006): 2947–54. http://dx.doi.org/10.1128/mcb.26.8.2947-2954.2006.

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ABSTRACT ING1 is a type II tumor suppressor that affects cell growth, stress signaling, apoptosis, and DNA repair by altering chromatin structure and regulating transcription. Decreased ING1 expression is seen in several human cancers, and mislocalization has been noted in diverse types of cancer cells. Aberrant targeting may, therefore, functionally inactivate ING1. Bioinformatics analysis identified a sequence between the nuclear localization sequence and plant homeodomain domains of ING1 that closely matched the binding motif of 14-3-3 proteins that target cargo proteins to specific subcell

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Lach, Boleslaw, Michelle Kameda-Smith, Sheila Singh, and Olufemi Ajani. "Development of an Atypical Teratoid Rhabdoid Tumor in a Meningioma." International Journal of Surgical Pathology 25, no. 6 (2017): 567–72. http://dx.doi.org/10.1177/1066896917707039.

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We describe an atypical teratoid rhabdoid tumor (AT/RT) with a component of low-grade and anaplastic rhabdoid meningioma in a 7-year-old child. The AT/RT was uniformly negative for INI1 and displayed immunoreactivity for vimentin, P53, CD99, cytokeratins with AE1/AE3 antibodies, epithelial membrane antigen, β-catenin, smooth muscle actin, E-cadherin, and S-100 protein. AT/RT was continuous, with small foci of recognizable low-grade and anaplastic meningioma. The low-grade meningioma was INI1 positive with scattered INI1-negative nuclei, whereas the remaining tumor components were INI1 negative

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Boese, Annette, Peter Sommer, Daniela Holzer, Reinhard Maier, and Ulf Nehrbass. "Integrase interactor 1 (Ini1/hSNF5) is a repressor of basal human immunodeficiency virus type 1 promoter activity." Journal of General Virology 90, no. 10 (2009): 2503–12. http://dx.doi.org/10.1099/vir.0.013656-0.

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Integrase interactor 1 (Ini1/hSNF5/BAF47/SMARCB1), the core subunit of the ATP-dependent chromatin-remodelling complex SWI/SNF, is a cellular interaction partner of the human immunodeficiency virus type 1 (HIV-1) integrase. Ini1/hSNF5 is recruited to HIV-1 pre-integration complexes before nuclear migration, suggesting a function in the integration process itself or a contribution to the preferential selection of transcriptionally active genes as integration sites of HIV-1. More recent evidence indicates, however, that, whilst Ini1/hSNF5 is dispensable for HIV-1 transduction per se, it may have

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Martin, K. L., and T. K. Smith. "The myo-inositol-1-phosphate synthase gene is essential in Trypanosoma brucei." Biochemical Society Transactions 33, no. 5 (2005): 983–85. http://dx.doi.org/10.1042/bst0330983.

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The de novo synthesis of myo-inositol occurs via a two-step process: first, glucose 6-phosphate is converted into inositol 1-phosphate by an INO1 (myo-inositol-1-phosphate synthase; EC 5.5.1.4); then, it is dephosphorylated by an inositol monophosphatase. The myo-inositol can then be incorporated into PI (phosphatidylinositol), which is utilized in a variety of cellular functions, including the biosynthesis of GPI (glycosylphosphatidylinositol) anchors. A putative INO1 was identified in the Trypanosoma brucei genome database and, by recombinant expression in Escherichia coli, was shown to be a

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Smith, Melissa E., Velasco Cimica, Srinivasa Chinni, et al. "Therapeutically targeting cyclin D1 in primary tumors arising from loss of Ini1." Proceedings of the National Academy of Sciences 108, no. 1 (2010): 319–24. http://dx.doi.org/10.1073/pnas.0913297108.

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Rhabdoid tumors (RTs) are rare, highly aggressive pediatric malignancies with poor prognosis and with no standard or effective treatment strategies. RTs are characterized by biallelic inactivation of the INI1 tumor suppressor gene. INI1 directly represses CCND1 and activates cyclin-dependent kinase (cdk) inhibitors p16Ink4a and p21CIP. RTs are exquisitely dependent on cyclin D1 for genesis and survival. To facilitate translation of unique therapeutic strategies, we have used genetically engineered, Ini1+/− mice for therapeutic testing. We found that PET can be used to noninvasively and accurat

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Cheng, Yulong, Yutong Su, Aijing Shan та ін. "Generation and Characterization of Transgenic Mice Expressing Mouse Ins1 Promoter for Pancreatic β-Cell-Specific Gene Overexpression and Knockout". Endocrinology 2016, № 1 (2016): 85–92. http://dx.doi.org/10.1210/en.2015-1104.

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Abstract The technologies for pancreatic β-cell-specific gene overexpression or knockout are fundamental for investigations of functional genes in vivo. Here we generated the Ins1-Cre-Dsred and Ins1-rtTA mouse models, which expressed the Cre recombinase or reverse tetracycline regulatable transactivator (rtTA) without hGH minigene under the control of mouse Ins1 promoter. Our data showed that the Cre-mediated recombination and rtTA-mediated activation could be efficiently detected at embryonic day 13.5 when these models were crossed with the reporter mice (ROSAmT/mG or tetO-HIST1H2BJ/GFP). The

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