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Journal articles on the topic 'Inc Chas T Main'

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Published: 28 July 2024

Last updated: 31 July 2025

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1

Willoughby, Jay. "Confessions of an Economic Hit Man." American Journal of Islam and Society 22, no. 2 (2005): 124–26. http://dx.doi.org/10.35632/ajis.v22i2.1719.

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Confessions of an Economic Hit Man is the story of why the so-calleddeveloping never seems to develop, as seen through the eyes of JohnPerkins, who was involved in “developing” several oil-rich nations. Theopening chapters deal with his childhood, which was permeated with elitismand ideas of how only the “right people” really mattered, his subsequentrebellion by defying his parents’ plan for his life, his initial contacts(through his wife) with government employment, and a 2-year Peace Corpsstint with an indigenous Indian tribe in Ecuador. While there, he wasrecruited by the National Security

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2

Du, Wei-Shih, Young-Ye Huang, and Chi-Lin Yen. "Fixed point theorems for nonexpansive mappings on nonconvex sets in UCED Banach spaces." International Journal of Mathematics and Mathematical Sciences 31, no. 4 (2002): 251–57. http://dx.doi.org/10.1155/s0161171202107113.

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It is shown that every asymptotically regular orλ-firmly nonexpansive mappingT:C→Chas a fixed point wheneverCis a finite union of nonempty weakly compact convex subsets of a Banach spaceXwhich is uniformly convex in every direction. Furthermore, if{T i}i∈Iis any compatible family of strongly nonexpansive self-mappings on such aCand the graphs ofT i,i∈I, have a nonempty intersection, thenT i,i∈I, have a common fixed point inC.

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Umekita, K., Y. Hashiba, R. Kudou, et al. "AB0268 HUMAN T-CELL LEUKAEMIA VIRUS TYPE 1 MAY INVALIDATE T-SPOT.TB RESULTS AMONG RHEUMATOID ARTHRITIS PATIENTS: A RETROSPECTIVE OBSERVATIONAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1432.1–1433. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1588.

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Background:In clinical rheumatology, interferon-γ release assays (IGRAs) have been reported as a useful diagnostic test for latent tuberculosis infection (LTBI) before beginning the administration of biologics such as anti-TNF therapies (1). CD4-positive T cells are the main target in Human T-cell leukaemia virus type 1 (HTLV-1) infection. Several reports suggest that the reaction of tuberculin skin test (TST) is attenuated in HTLV-1-positive individuals compared with that in HTLV-1-negative individuals (2). However, it remains unclear whether IGRAs are reliable for detecting TB infection amon

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Barcellini, Wilma, Anna Ines Gregorini, Giulia Soverini, et al. "Iron Overload and Cytokine Serum Levels in Congenital Hemolytic Anemias." Blood 128, no. 22 (2016): 2458. http://dx.doi.org/10.1182/blood.v128.22.2458.2458.

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Abstract Background: Congenital hemolytic anemias (CHAs) are a heterogeneous group of inherited RBC disorders including membrane and enzyme defects and dyserythropoietic anemias. Iron overload is a well recognized complication of hereditary hemoglobinopathies, both in transfusion-dependent and independent cases. However, little is known in congenital hemolytic anemias, with the exception of anecdotic reports in pyruvate kinase deficiency and dyserythropoietic anemias. Aim: to describe the clinical and hematological features at diagnosis and enrolment, to investigate iron overload by hepatic an

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Tkachev, Victor, Frank Kuhnert, Scott N. Furlan, et al. "Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates." Blood 132, Supplement 1 (2018): 2027. http://dx.doi.org/10.1182/blood-2018-99-110030.

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Abstract The Notch signaling pathway is an evolutionarily conserved, cell-cell communication system with critical functions in organogenesis and tissue homeostasis, including hemato- and immuno-poiesis. Recent data have revealed important roles for Notch in the regulation of mature T cell differentiation and function. Studies in mouse models have identified Notch as a critical regulator of pathogenic T-cell responses during acute GVHD (aGVHD) (Zhang Y, 2011, Blood). However, the exact biological effects and the therapeutic potential of Notch pathway manipulation in clinical settings remains un

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Sneha, M. S., and Prasad K. Krishna. "Analysis of Business Strategies of Salesforce.com Inc." International Journal of Case Studies in Business, IT and Education (IJCSBE) 2, no. 1 (2018): 37–44. https://doi.org/10.5281/zenodo.1252028.

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Salesforce.com is a cloud computing company originated from SanFrancisco of America. Salesforce also enhances its business on commercial applications of social networking through achievement and internal development. Company headquarters in SanFrancisco as of early 2016, it standout among the most much esteemed American cloud computing organizations with a market capitalization above $61 billion. In August 2017, Salesforce declared that it had come to the $10 billion income run rate turning into the main venture cloud organization to do as such. In spite of the fact that its income originates

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Duvic, Madeleine, Timothy M. Kuzel, Nam H. Dang, et al. "A Dose Finding Lead-in Study of E7777 (Diphtheria toxin fragment-Interleukin-2 Fusion Protein) in Persistent or Recurrent Cutaneous T-Cell Lymphoma (CTCL)." Blood 124, no. 21 (2014): 3097. http://dx.doi.org/10.1182/blood.v124.21.3097.3097.

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Abstract Introduction: E7777 is a recombinant cytotoxic fusion protein composed of diphtheria toxin fragments A and B and human interleukin-2. E7777 has the same amino acid sequence as denileukin diftitox (DD) (approved as ONTAK in the USA for treatment of persistent or recurrent CTCL) but with improved purity and an increased percentage of active protein monomer species. This study is a pivotal multicenter open-label single-arm study comprising a Lead-In part (approx. 20 pts) to select the E7777 dose for the Main Study (70 patients [pts]) in which primary efficacy and safety of E7777 is asses

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Song, Hoyoung. "Park Un's ‘philosophy of self-cultivation’: Focusing on the System of Thought in 'Gyukmongpyeon'." Institute of Korean Cultural Studies Yeungnam University 84 (August 31, 2023): 305–36. http://dx.doi.org/10.15186/ikc.2023.8.31.10.

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This article examines the system of thought concerning Park Un's philosophy of self-cultivation, based on one of his two main works, Gyukmongpyeon. Park Un was a representative scholar of Neo-Confucianism from the Gyeongbuk Seonsan region during the middle period of the Joseon Dynasty. He gained widespread recognition for his filial devotion to his parents. He studied under Park Young along with the Kim brothers, Kim Chwiseong and Kim Chwimun, contributing to the nationwide prominence of the Songdang school of thought. However, following the last wishes of his father, Park Jongwon, who h

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Walker, Brian A., Shweta S. Chavan, Jie He, et al. "A Survey of Fusion Genes in Myeloma Identifies Kinase Domain Activation Which Could be Targeted with Available Treatments." Blood 128, no. 22 (2016): 117. http://dx.doi.org/10.1182/blood.v128.22.117.117.

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Abstract Introduction Although fusion genes other than the immunoglobulin (Ig) translocation, t(4;14), which results in IGH-WHSC1fusions, are not frequently detected in multiple myeloma (MM), recent evidence suggests that kinase fusion gene fusions do occur relatively frequently and may inform on treatment algorithms. Here we use a hybrid-capture based, next-generation sequencing assay to survey fusion genes in patients with MM. Methods We report on 1421 samples from 958 individuals diagnosed with either monoclonal gammopathy of unknown significance (MGUS), smoldering multiple myeloma (SMM) or

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Du, Xiaoru. "IDEO Product Development Case Analysis." BCP Business & Management 13 (November 16, 2021): 396–401. http://dx.doi.org/10.54691/bcpbm.v13i.116.

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IDEO is one of the successful product development companies, it established in 1991 and combined with 3 companies (David Kelley Design, ID Two and Matrix Product Design). As one of the world’s leading design firms, IDEO won a large number of awards than other product development firms. This company has a rapidly development in last several years, owned over 660 employees in the various disciplines. IDEO help organizations in the public and private sectors to find new design approach to innovate and grow, its major well-know clients are include Apple Inc., AT&T, Coca-Cola, Microsoft, Steelc

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Shah, Nilay R., Dawn E. Jaroszewski, Awais Ashfaq, et al. "SynCardia Portable Freedom Driver: A Single-Center Experience with 11 Patients." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 10, no. 3 (2015): 188–94. http://dx.doi.org/10.1097/imi.0000000000000161.

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Objective The portable Freedom Drive (SynCardia Inc, Tucson, AZ USA) for total artificial heart (TAH-t) support was approved for an investigational device exemption study in March 2010. We review our center's experience with the portable driver. Methods A retrospective review was conducted of patients who underwent TAH-t implantation and transfer to portable driver from September 2008 to June 2012, with follow-up through December 2012. Results A total of 30 patients underwent TAH-t implantation during this time period, with 11 patients successfully transferred to the Freedom Driver. Transfer t

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Paludo, Jonas, Radhika Bansal, Adam T. Holland, et al. "Pilot Implementation of Remote Patient Monitoring Program for Outpatient Management of CAR-T Cell Therapy." Blood 138, Supplement 1 (2021): 568. http://dx.doi.org/10.1182/blood-2021-149103.

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Abstract Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy is an effective treatment that has transformed hematologic malignancy management. However, its significant short-term toxicities, mainly cytokine release syndrome (CRS) and neurotoxicity, require frequent monitoring almost universally achieved via prolonged inpatient admissions. We have reported our institution's specialized, multi-disciplinary hospital-based outpatient (HBO) CAR-T service and experience (Bansal et.al, ASCO 2021). To enhance the HBO practice, we implemented a remote patient monitoring (RPM) program, compri

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Munoz, Javier, Samantha Jaglowski, Matthew S. McKinney, et al. "A Phase 1 Study of ACTR087 in Combination with Rituximab, in Subjects with Relapsed or Refractory CD20-Positive B-Cell Lymphoma." Blood 134, Supplement_1 (2019): 244. http://dx.doi.org/10.1182/blood-2019-123810.

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Background: The Antibody-Coupled T-cell Receptor (ACTR) platform is an autologous engineered T-cell therapy that combines the cell-killing ability of T cells and the tumor-targeting ability of co-administered antibodies to exert potent antitumor immune responses. ACTR087 comprises the extracellular domain of CD16 linked to a CD3ζ-signaling domain and a 4-1BB co-stimulatory domain. Here we present the clinical experience from Study ATTCK-20-2 (NCT02776813), a multicenter, phase 1 study of ACTR087 in combination with rituximab in subjects with relapsed or refractory (R/R) CD20+ NHL. Methods: The

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Trabucco, Sally E., Ethan S. Sokol, Jay A. Moore, et al. "Prediction and Characterization of Diffuse Large B-Cell Lymphoma (DLBCL) Cell of Origin (COO) Subtypes Using Genomic Features from Targeted Next-Generation Sequencing." Blood 132, Supplement 1 (2018): 1561. http://dx.doi.org/10.1182/blood-2018-99-116677.

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Abstract Introduction: DLBCL has two COO subtypes: Activated B Cell (ABC) and Germinal Center B cell (GCB). Patients with the ABC subtype have a poor prognosis compared to those with GCB, and COO can be predictive for response to some new therapeutic agents. Traditionally, COO subtype has been determined by microarray (ABC, GCB, unclassified), IHC-based algorithms (GCB or non-GCB), or expression-based Nanostring Lymph2Cx (ABC, GCB, unclassified). Some reports have failed to show a prognostic difference between GCB and non-GCB when employing IHC-based algorithms. This has led some to adopt the

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Watkins, Benjamin, Yvonne Suessmuth, Kayla Betz, et al. "Transcriptomic Analysis of CD4+ T Cell Dysfunction during Gvhd: Evidence for Profound Reprograming of T Cell Signaling during Acute Gvhd That Is Controlled during CD28:CD80/86 Costimulation Blockade with Abatacept." Blood 134, Supplement_1 (2019): 596. http://dx.doi.org/10.1182/blood-2019-131955.

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Although acute graft-versus-host-disease (AGVHD) is one of the major causes of non-relapse mortality after hematopoietic stem cell transplant (HCT), we are still unable to predict which patients will develop the most severe form of this disease, or which molecular pathways are dysregulated in the T cells that cause disease. Thus, understanding the molecular features of AGVHD is a critical unmet need. To address this, we have performed a companion mechanistic study as a part of our completed Phase 2 trial of abatacept, a CD28:CD80/86 costimulation blockade agent, for severe AGVHD prevention (Cl

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Foureau, David M., Manisha Bhutani, Myra Robinson, et al. "Ex Vivo Assessment of Tnb-383B, a Bcma-Bispecific Antibody, Against Primary Tumor and Endogenous T Cells from Relapsing Multiple Myeloma Patients." Blood 132, Supplement 1 (2018): 1940. http://dx.doi.org/10.1182/blood-2018-99-118881.

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Abstract INTRODUCTION: The human B-Cell maturation antigen (BCMA) is a surface marker that is highly expressed on plasma cells and has been recognized as a novel target in multiple myeloma (MM). TNB-383B is a fully human bispecific monoclonal IgG4 antibody. TNB-383B consists of 2 heavy and 1 light chain(s) paired through knob-in-hole technology. The first heavy chain and a kappa light chain form the paratope to recognize and bind human CD3. The second heavy chain is comprised of two identical VH domains in sequence and targets human BCMA with high affinity and avidity. Herein, we describe the

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A.B.M., Kamal Pasha, Mozumder Sagar, and Chakma Kornia. "The impact of Jhum cultivation on hilly area (Rangamati, Khagrachari)." International Research Journal of Science, Technology, Education, and Management 1, no. 1 (2021): 97–107. https://doi.org/10.5281/zenodo.5195791.

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In our research work, we surveyed Jhum cultivation of Langadu Upazila, Rangamati, and Babuchara, Dighinala in Khagrachari and collected data based on interviews. This survey was conducted from August 2020 to December 2020. The objectives of this survey were to understand the impact of Jhum cultivation on environmental degradation, and we also reviewed the existing crops production system in that hilly area which gave us an idea about the current situation of Jhum cultivation. Data was collected in three parts, we collected general information from Jhum landowners by a survey questionnaire, dem

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Astone, Giuseppina, Luca Vincenzo Cappelli, William Chiu, et al. "Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens." Blood 138, Supplement 1 (2021): 865. http://dx.doi.org/10.1182/blood-2021-153995.

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Abstract Introduction: Peripheral T-cell lymphomas (PTCLs) include heterogeneous entities of rare and aggressive neoplasms. The improved understanding of the biological/molecular mechanisms driving T-cell transformation and tumor maintenance has powerfully propelled new therapeutic programs. However, despite this progress, PTCLs remain an unmet medical need. Recurrent aberrations and the deregulated activation of distinct signaling pathways have been mapped and linked to selective subtypes. The JAK/STAT signaling pathway's deregulated activation plays a pathogenetic role in PTCL, including ALC

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Sportes, C., F. Hakim, M. Krumlauf, et al. "Effects of rhIL-7 administration in humans on in vivo expansion of naïve, memory and effector subsets of CD4+ & CD8+ T-cells." Journal of Clinical Oncology 24, no. 18_suppl (2006): 2504. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.2504.

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2504 Background: IL-7 has a critical and non-redundant role in T-cell lymphopoiesis and peripheral T-cell homeostasis. IL-7 administration may prove clinically valuable in conditions of disease induced (HIV) or iatrogenic T-cell depletion and for modulation of vaccine immune responses. In the first phase I study in humans, recombinant human interleukin-7 (“CYT 99–007”, Cytheris Inc., Rockville, MD) was administered subcutaneously every other day for two weeks in adults with refractory malignancies at 3, 10, 30 and 60 μg/kg/dose. Biologic activity, defined as a 50% increase over baseline of per

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Parkinson, Gerneiva, Anees B. Chagpar, Kellie Alleyne-Mike, et al. "Investigation of HBOC germline mutations in women diagnosed with breast cancer in Trinidad and Tobago." Journal of Clinical Oncology 37, no. 15_suppl (2019): 6574. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.6574.

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6574 Background: Trinidad and Tobago (T&T) is the southern-most Caribbean island, and according to the WHO/PAHO, it has the 2nd highest breast cancer mortality rate in the region. Notably, a large proportion of breast cancer cases in T&T occur at a young age; with nearly 36% of them being diagnosed under the age of 50. There is a known association between a younger age at diagnosis and Hereditary Breast and Ovarian Cancer syndrome (HBOC). Yet, the prevalence of HBOC mutations remains unknown in T&T, as genetic counseling and testing services are extremely limited in the region. The

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Yanofiyanti, Tri. "ASUHAN KEBIDANAN KOMPREHENSIF PADA NY. K DI KLINIK UTAMA LESTARI TEMBILAHAN." Jurnal Kesehatan Husada Gemilang 6, no. 1 (2023): 22–32. http://dx.doi.org/10.61129/jkhg.v6i1.74.

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Comprehensive midwifery care is care that is carried out thoroughly from pregnancy to family planning to reduce Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR). At the Utama Lestari Clinic, from January to December 2021, there were 539 pregnant women, pregnant women, BBL, 297 postpartum women and 963 family planning acceptors. Objective: To provide comprehensive care for Mrs. “K” at Klinik Utama Lestari using Varney's line of thought and documented in SOAP form. Methods: Midwifery management plan with Varney's line of thought and documented in SOAP form, implemented at Klinik Uta

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Syaiputra Wahyuda Meisa Diningrat, Luluk Janah, and Sakinatul Mardiyah. "Modified Bottle Cap for Improving Children’s Arithmetic Ability." JPUD - Jurnal Pendidikan Usia Dini 13, no. 2 (2019): 249–63. http://dx.doi.org/10.21009/jpud.132.04.

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The preliminary study showed that the main problem, however, faced by kindergarten students are lack of mathematics skill, such arithmetic ability in kindergarten Galis. Therefore, the present study aims to investigate the effectiveness of a modified bottle cap as an educational game tool towards enhancement of arithmetic ability. Samples were prepared for the quasi-experiment research design involving 60 children, aged 4-5 years. A detailed comparison is made between the experimental condition, consisted of 30 students, received the educational game tool activities and the control condition w

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Prorok, Viktor. "Efficiency of corporate governance: measurement toolkit and relationship with ownership reforms." Economy and Entrepreneurship, no. 52 (June 4, 2024): 200–211. https://doi.org/10.33111/ee.2024.52.prorokv.

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The historical aspects of the emergence of corporate governance and the regulatory features of the OECD Guidelines on corporate governance for state-owned enterprises are considered. Methodological approaches to assessing organizational effectiveness are outlined, in particular target, systemic, functional, intraorganizational, competitive and compositional concepts, as well as the concept of balance of interests. The criterial base of such methods for assessing the level of corporate governance as the Davis Global Advisors Inc. Index, Creighton-Miller and Warman Corporate Governance Risk Inde

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Querol, Felipe, Sofía Pérez-Alenda, Juan Eduardo Megias, et al. "Benefits of Ehl Factor VIII Replacement Therapy in Hemophilia: Observations on Coverage, Physical Activity and Phisiotherapy." Blood 134, Supplement_1 (2019): 2455. http://dx.doi.org/10.1182/blood-2019-125651.

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Introduction: Prevention of haemophilic arthropathy and quality of life´s (QoL) improvement are still the main goals in the haemophilia community. Haemophilic arthropathy is the result of clinical and subclinical bleeding during everyday activities and/or traumatic situations. Prophylaxis with extended half-life (EHL) factor replacement therapy is understood as an improvement solution for factor VIII (FVIII) PK properties, as half-life (T1/2) and area under the curve (AUC), however few real world data are yet available. EHL improved pharmacokinetic (PK) properties might directly drive into a r

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Vovchenko, L., and N. Zhachko. "Dental status of children with congenital defects of the heart and main vessels in Ukraine." SUCHASNA STOMATOLOHIYA 118, no. 1 (2024): 21. http://dx.doi.org/10.33295/1992-576x-2024-1-21.

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Introduction: Congenital heart disease (CHD) is one of the most common congenital defect worldwide. The increase in the number of patients with CHD creates a group of people with individual special care needs, including dental care. Purpose: to evaluate oral health conditions (oral hygiene, caries experience, periodontal health) in children with CHD and compare their caries experience with the one of the group of healthy children in Ukraine. Materials and methods: Fifty-eight children with congenital heart disease and eighty healthy children aged 3-15 years were enrolled in this study. Accordi

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Strozenko, Lyudmila A., Viktor S. Ponomarev, Yuriy F. Lobanov, et al. "Polymorphic substitutions in folate cycle genes as predictors of hyperhomocysteinemia in children." Russian Pediatric Journal 27, no. 1 (2024): 34–39. http://dx.doi.org/10.46563/1560-9561-2024-27-1-34-39.

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Introduction. Mutant alleles of genes of folate cycle enzymes can lead to the significant deterioration of its function and varying severity of pathology. Several defects in these genes lead to severe hyperhomocysteinemia, the most common form of which is a deficiency of cystathionine beta-synthase B.  Aim: to establish polymorphic substitutions in the genes of folate cycle enzymes that contribute to the formation of hyperhomocysteinemia in children. Materials and methods. Two hundred seventy one children aged of 13–18 years were examined. The analysis of genetic polymorphisms of t

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Gazaleeva, Galina, Liudmila Nazarenko, and Elena Dmitrieva. "The research of the absorption potential effect of the minerals surface on the cassiterite flotation process." Izvestiya vysshikh uchebnykh zavedenii Gornyi zhurnal, no. 3 (May 14, 2020): 70–79. http://dx.doi.org/10.21440/0536-1028-2020-3-70-79.

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Introduction. The use of flotation for tin additional recovery and in order to increase integrated use of raw materials is one of the main trends in tin ores beneficiation technology development. Research aim is to identify the mechanism of reagents action on the pulp particles surface during the flotation of tin-containing products containing cassiterite. 78 "Izvestiya vysshikh uchebnykh zavedenii. Gornyi zhurnal". No. 3. 2020 ISSN 0536-1028 Methodology. Pulp absorption potential was measured on Dispersion DT-310 electro-acoustic spectrometer from Dispersion Technolodgy Inc., USA. The object

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Yundra Liana, Elva. "ASUHAN KEBIDANAN KOMPREHENSIF PADA NY “R” DI KLINIK UTAMA LESTARI TEMBILAHAN TAHUN 2021." Jurnal Kesehatan Husada Gemilang 5, no. 1 (2022): 31–38. http://dx.doi.org/10.61129/jkhg.v5i1.66.

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Background: Comprehensive care in midwifery care is a series of continuous and comprehensive activities, starting from pregnancy, childbirth, postpartum, family planning services. Purpose: Able to carry out comprehensive midwifery care based on the Varney management approach and documented in the SOAP method at the Lestari main clinic in 2021. Result: This comprehensive midwifery care was carried out on Mrs. R. Age 35 years G3P2A0H2 In ANC care that met the 10 T standard, the INC went well, the stage I lasted 2 hours 10 minutes, the stage II lasted 9 minutes, the stage III lasted 10 minutes, a

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Savastano, Maria Cristina, Clara Rizzo, Gloria Gambini, et al. "Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections." Diagnostics 11, no. 11 (2021): 1958. http://dx.doi.org/10.3390/diagnostics11111958.

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Purpose: To assess choriocapillaris vascular density (VD) in healthy and advanced exudative age-related macular degeneration (ae-AMD) patients by new full-range optical coherence tomography angiography (OCT-A). Method: In this observational, cross-sectional study, 21 healthy and 21 ae-AMD eyes, already treated with anti-VEGF, were enrolled. Angio-View retina patterns centered on fovea (6.4 × 6.4 mm) were acquired for all participants using Solix full-range OCT (Optovue Inc., Freemont, CA, USA). The main outcome was to compare choriocapillaris VD between healthy and ae-AMD eyes. Automated measu

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Konovalova, G. V., and E. I. Koveshnikova. "Effects of experimental <i>Trichinella spiralis</i> larvae infection in rats and mice on hematological and biochemical parameters of the host at different infection stages." Russian Journal of Parasitology 17, no. 2 (2023): 250–56. http://dx.doi.org/10.31016/1998-8435-2023-17-2-250-256.

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The purpose of the research is the study of effects of experimental Trichinella spiralis infection in rats and mice on hematological and biochemical blood parameters of the host at different infection stages.Materials and methods. The experiment was performed on mature outbred male rats and male mice that were infected by T. spiralis larvae orally administered at the rate of 10 larvae/1 g of body weight. Blood samples were taken from the rats at 40 days and 3 months after infection; from the mice, on day 40 after infection. The main parameters of peripheral blood in the rats were determined by

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Mazhara, G. A. "Modeling of the Optimal Investment Portfolio Focused on Risk Minimization." Modern Economics 38, no. 1 (2023): 69–75. http://dx.doi.org/10.31521/modecon.v38(2023)-11.

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Abstract. Introduction. Portfolio optimization modelling is a study aimed at determining the best way to allocate an investor's funds between securities of different companies. The study uses a number of methods and approaches, such as: multicriteria optimization methods - optimization of criteria for minimum and maximum, modeling of the optimal stock portfolio with minimal risk, to determine the best way to allocate funds that will help investors achieve maximum return while minimizing risk. Purpose. There are a lot of publicly traded companies in the modern American stock market. Having chos

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Wee, Rachel K., Hiroyuki Takamatsu, Ryoichi Murata, et al. "A Comparison of Minimal Residual Disease Detection Among ASO-PCR, Dd-PCR and Deep-Sequencing in Patients with Multiple Myeloma Who Underwent Autologous Stem Cell Transplantation." Blood 126, no. 23 (2015): 1782. http://dx.doi.org/10.1182/blood.v126.23.1782.1782.

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Abstract Background: Most patients with multiple myeloma (MM) are considered to be incurable, and relapse, due to minimal residual disease (MRD), is the main cause of death among these patients. Even though allele-specific oligonucleotide real-time quantitative PCR (ASO-qPCR) of immunoglobulin heavy chain gene rearrangement has been used to assess the MRD in MM due to its excellent sensitivity and specificity, ASO-qPCR has a major limitation in its relative quantification method because it needs a reference standard curve, which is usually made with dilutions of diagnostic myeloma DNA or from

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Benevolenskaya, S., I. Kudryavtsev, M. Maria, et al. "AB0033 T- AND B-CELL SUBSETS AS ADDITIONAL DIAGNOSTIC TOOL FOR PRIMARY SJOGREN’S SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1151–52. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4010.

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BackgroundSystemic lupus erythematosus (SLE) and primary Sjogren’s syndrome (pSS) are chronic autoimmune diseases with complex pathogenesis. T-lymphosytes are known to be prime effectors of autoimmune diseases, while B-lymphosytes play a key role as sources of antibodies and antigen presenting cells. Considering the implications of T- and B-cells in the pathophysiology of SLE ans pSS, the assessment of their distribution in the blood could be helpful in the complex process of determining a precise diagnosis.ObjectivesThe study aimed to compare composition of peripheral blood T- and B-cell subs

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Cichocki, Frank, Bahram Valamehr, Dhifaf Sarhan, et al. "Development and Scale-up of a Novel GMP Method for Enrichment and Expansion of Terminally Differentiated Adaptive Natural Killer Cells (FATE-NK100) with Enhanced Anti-Tumor Function." Blood 128, no. 22 (2016): 1225. http://dx.doi.org/10.1182/blood.v128.22.1225.1225.

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Abstract Natural killer (NK) cells are innate lymphoid cells that mediate immune responses against pathogens and cancer. Human NK cells are distinguished by the surface phenotype CD3-CD56+ and differential expression of the CD56 surface antigen defines subsets. CD56bright NK cells are presumed to be precursors of CD56dim NK cells, and terminal maturation of CD56dim NK cells is associated with acquisition of CD57. Rather than being an immunosenescence marker CD57 acquisition represents a shift toward greater effector function, including increased CD16 signaling (Fc receptor responsible for trig

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Modarres, Maryam, Maryam Abunasri, Fatemeh Alhani, and Elham Ebrahimi. "The Effectiveness of Implementing Family-Centered Empowerment Model on Irrational Thoughts of Iranian Infertile Women: A Randomized Clinical Trial." Journal of Caring Sciences 11, no. 4 (2022): 224–31. http://dx.doi.org/10.34172/jcs.2022.22.

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Introduction: Infertility is one of the main problems of the family and is one of the factors that determine the identity and personality of Iranian infertile women. Family-centered empowerment model is a step toward increasing the self-efficacy of patients and enabling them to take responsibility of their illness. This study aimed to determine the effectiveness of applying family-centered empowerment model on irrational thoughts of Iranian infertile women. Methods: This study was a randomized clinical trial conducted on 80 infertile women and their husbands that were randomly divided into two

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Stoddart, Angela, Anthony Fernald, Rachel Joy Bergerson, et al. "Retroviral Insertional Mutagenesis In Egr1+/- mice, Haploinsufficient For a Human Del(5q) Myeloid Leukemia Gene, Develop Myeloid Neoplasms With Proviral Insertions In Genes Syntenic To Human 5q." Blood 122, no. 21 (2013): 1275. http://dx.doi.org/10.1182/blood.v122.21.1275.1275.

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Abstract Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after treatment with chemotherapy and/or radiotherapy, typically for a primary malignant disease. Loss of the long arm of chromosome 5, del(5q), is the most common recurring cytogenetic abnormality and is observed in 40% of t-MN patients, as well as 10-15% of patients with primary MDS or AML de novo. These deletions typically encompass over 70Mb [spanning 5q14-q33] and numerous genes, making the identification of relevant del(5q) genes very challenging. In previous studies, we identified a commonly de

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Luangwilai, Thiansiri, Harvinder Sidhu, and Mark Nelson. "Understanding the factors affecting the self-heating process of compost piles: Two-dimensional analysis." ANZIAM Journal 63 (June 6, 2022): C15—C29. http://dx.doi.org/10.21914/anziamj.v63.17119.

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Industrial compost piles contain large volumes of bulk organic materials. Normally, there are two main heat generation processes—oxidation of cellulosic materials and biological activity within the compost pile. Biological heating occurs at a lower temperature range, but it may `kick-start' the oxidation reaction. Nevertheless, biological heating is desirable and is a key component in composting operations. However, there are cases when the temperature within the compost piles increases beyond the ignition temperature of cellulosic materials which can result in spontaneous ignition. This inves

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Afrianti, Lidia. "ASUHAN KEBIDANAN KOMPREHENSIF “NY. V” DI KLINIK UTAMA LESTARI." Jurnal Kesehatan Husada Gemilang 5, no. 2 (2022): 35–44. http://dx.doi.org/10.61129/jkhg.v5i2.70.

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Comprehensive care is a series of ongoing and comprehensive activities so as to be able to suppress or reduce MMR and IMR. Objectives Able to provide comprehensive midwifery care services with a midwifery management approach with a varney mindset documented in the form of SOAP. The method used is the midwifery management approach with the Varney step mindset as outlined in the form of SOAP. Comprehensive midwifery care is carried out from February to April at the Main Lestari Tembilahan Clinic in 2021. Comprehensive midwifery care is carried out on Mrs. V Age 29 years G3P2A0. The results of AN

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Kakkad, Nimisha, Naveen S. Yadav, Puja Hazari, et al. "Comparative Evaluation of Tensile Bond Strength of Poly Ether Ether Ketone (PEEK) and Zirconia Copings Using Resin Cement with or without Adhesive: An In Vitro Study." Materials 15, no. 12 (2022): 4167. http://dx.doi.org/10.3390/ma15124167.

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This in vitro research aimed to evaluate the Tensile Bond Strength of Poly Ether Ether Ketone and Zirconia copings using resin cement with or without Visio.link adhesive. From commercially available Zirconia and PEEK, blocks were machined milled using (CAD)/(CAM) to obtain 20 Zirconia and 20 PEEK copings. These specimens were sandblasted using 110 μm of alumina. The two main groups (20 Zirconia and 20 PEEK copings) were divided further into 4 subgroups, GROUP 1 (n = 10) PEEK substructure with self-adhesive resin cement without pretreatment, and GROUP 2 (n = 10) PEEK substructure with self-adhe

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Al-keilani, Maha S., and Dua H. Alsmadi. "THE HDAC INHIBITOR SODIUM PHENYLBUTYRATE ENHANCES THE CYTOTOXICITY INDUCED BY 5-FLUOROURACIL, OXALIPLATIN, AND IRINOTECAN IN COLORECTAL CANCER CELL LINES." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 1 (2018): 155. http://dx.doi.org/10.22159/ijpps.2018v10i1.22947.

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Objective: The main objective of this study was to evaluate the ability of sodium phenylbutyrate (NaPB) to enhance the cytotoxicity of 5-fluorouracil, oxaliplatin, and irinotecan against colorectal cancer cell lines expressing wild-type and mutant p53.Methods: The antiproliferative effect of NaPB alone or in combination with 5-fluorouracil, oxaliplatin, or irinotecan in HCT-116 and HT-29 colorectal cancer cell lines was investigated using the MTT cell proliferation assay. IC50 values were calculated using Compusyn Software 1.0 (Combosyn Inc.). Synergy values (R) were calculated using the ratio

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Coppe, Alessandro, Emma I. Andersson, Andrea Binatti, et al. "Subset-Specific Recurrence of Mutations and Identification of Functional Modules Provides New Clues about the Pathogenesis of Large Granular Lymphocyte Leukemia." Blood 128, no. 22 (2016): 4117. http://dx.doi.org/10.1182/blood.v128.22.4117.4117.

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Abstract Background: Large granular lymphocyte (LGL) leukemia is a rare disease characterized by a clonal persistence of cytotoxic T cells or natural killer (NK) cells. Patients usually suffer from cytopenias and other organ-related autoimmune phenomena. These are putatively mediated by the cytotoxic LGL cells constitutively activated following an antigen-driven immune response. In addition to gain-of-function mutations in the STAT3 gene, which occur in 40-50% of patients, recurrent alterations only in the STAT5b and TNFAIP3 tumor suppressor genes have been described thus far. However, based o

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Byčenkienė, Steigvilė, Touqeer Gill, Abdullah Khan, Audrė Kalinauskaitė, Vidmantas Ulevicius, and Kristina Plauškaitė. "Estimation of Carbonaceous Aerosol Sources under Extremely Cold Weather Conditions in an Urban Environment." Atmosphere 14, no. 2 (2023): 310. http://dx.doi.org/10.3390/atmos14020310.

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The present study investigated the characteristics of carbonaceous species in an urban background site. Real-time measurements of inorganic (sulfate, nitrate, ammonium, chloride, and black carbon [BC]) and organic submicron aerosols (OA) were carried out at the urban background site of Vilnius, Lithuania, during January–February 2014. An aerosol chemical speciation monitor (ACSM, Aerodyne Research Inc., Billerica, MA, USA) and co-located 7-λ aethalometer (AE-31, Magee Scientific, Berkeley, CA, USA) were used to analyze the chemical compositions, sources, and extinction characteristics of the P

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Wang, Meng, Iulian Pruteanu, Adam D. Cohen, et al. "Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors." Blood 134, Supplement_1 (2019): 622. http://dx.doi.org/10.1182/blood-2019-122513.

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CD19-specific chimeric antigen receptor (CAR) T cell therapies have been highly effective against B cell malignancies. We previously demonstrated that differential responses to anti-CD19 CAR T cell therapy in chronic lymphocytic leukemia (CLL) are associated with early memory T cell signature in apheresed, pre-manufacturing T-cells (CAR T-cell precursors). We tested the hypothesis that the composition of CAR-T precursor cells determines clinical efficacy in adult and pediatric Acute Lymphoblastic Leukemia (ALL), Non-Hodgkin's Lymphoma (NHL), Multiple Myeloma (MM), and CLL. Apheresed T cells we

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Ferrer, Gerardo, Byeongho Jung, Aslam Rukhsana, et al. "Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia." Blood 132, Supplement 1 (2018): 239. http://dx.doi.org/10.1182/blood-2018-99-114799.

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Abstract In chronic lymphocytic leukemia (CLL), bidirectional interactions of leukemic B cells with components of a complex, yet incompletely defined tumor microenvironment (TME) are critical for leukemic cell survival and proliferation. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, blocks signals that are crucial for survival of CLL cells which are delivered by the B cell receptor (BCR) and certain other receptors. However since BTK and its family members are expressed by other cell types, ibrutinib can also affect non-leukemic cells, thereby altering their function. Here, we focused

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Ashgi, Findy, and Adi Pancoro. "Analisis Single Nucleotide Polymorphism Gen Faktor Transkripsi MYB dalam Biosintesis Antosianin Kulit Buah Mangga (Analysis of Single Nucleotide Polymorphism Gene Transcription Factor MYB in Mango Skin Anthocyanin Biosynthesis)." Jurnal Hortikultura 31, no. 1 (2021): 1. http://dx.doi.org/10.21082/jhort.v31n1.2021.p1-10.

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<p>Perkembangan pasar bebas berdampak terhadap selera produk-produk pertanian, seperti warna buah mangga. Antosianin merupakan senyawa yang bertanggung jawab dalam menginduksi warna pada buah. Senyawa ini diregulasi oleh gen faktor transkripsi MYB. Mutasi Single Nucleotide Polymorphism (SNP) daerah ekson gen MYB dapat mengubah asam amino yang memengaruhi aktivitas enzim yang mengakibatkan munculnya variasi fenotipe warna buah di antara individu-individu dalam spesies yang sama. Penelitian ini bertujuan menemukan SNP pada gen MYB dari kulit buah mangga varietas Arum Manis, Gedong Gincu, M

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Lopez, Joaquin Martinez, Margarita Sanchez Beato, Martinez Nerea, et al. "Characterization of Subclonal Changes Along Progression in Multiple Myeloma." Blood 120, no. 21 (2012): 2924. http://dx.doi.org/10.1182/blood.v120.21.2924.2924.

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Abstract Abstract 2924 Background: Clonal composition and clone dynamic changes of neoplasms are a controversial issue, whose investigation is now facilitated by the development of massive parallel sequencing. Here we have analyzed the changes in the mutational spectrum associated with progression, treatment response and relapse in a multiple myeloma patient. We sequenced exomes for the primary quiescent-tumor, the progression and the relapsed samples. M&M: Patient and samples description Samples from asymptomatic, progression and relapse phases were compared by FISH and Whole exome massiv

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Patay, Bradley A., Andrew Carson, Timothy J. Martins, et al. "Precision Medicine Assays Detect Novel Targetable FLT3 Fusions Amenable to Therapeutic Intervention in a Patient with Refractory Acute Myeloid Leukemia." Blood 128, no. 22 (2016): 5170. http://dx.doi.org/10.1182/blood.v128.22.5170.5170.

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Abstract Context: The 5-year survival rate for acute myeloid leukemia (AML) is 26.6%. The prognosis of patients with adverse events such as older age or unfavorable risk cytogenetics remains poor, even for those who undergo allogeneic hematopoietic cell transplant. AML is a heterogeneous disease and novel N-of-1 clinical trial designs may offer benefit to individuals compared to conventional clinical trials by offering improved utilization of investigational chemotherapy regimens. Precision medicine based assays that reveal a deeper understanding of the cancer biology and potential for novel t

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Cornillon, Jérôme, Lena Absi, Aurélie Bourmaud, et al. "Early Mixed T-Cell Chimerism After Allogeneic Hematopoietic Stem Cells Transplantation Is Highly Predictive For Progression Free Survival." Blood 122, no. 21 (2013): 2079. http://dx.doi.org/10.1182/blood.v122.21.2079.2079.

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Abstract Introduction Chimerism analysis after allogeneic hematopoietic stem cells transplantation (HSCT) allows documentation and understanding of important clinical events such as engraftment, graft failure, and/or relapse. Few data are available on whether T-cell chimerism might be more informative than global chimerism. In this study, we focused on selective CD3+ T-cell chimerism and its interest to predict events after allogeneic HSCT. Methods This is a single center retrospective study. Only patients with a survival more than 3 months were included. Information concerning donors, recipie

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Wolohan, John T. "The Sport Lawyer’s Guide to Legal PeriodicalsWritten by Glenn Wilde M. Wong and T. Jesse Published 1994 by William S. Hein & Co., Inc., 1285 Main Street, Buffalo, New York, 14209-1987 (678 pages, $75.00)." Journal of Legal Aspects of Sport 4, no. 2 (1994): 72–73. http://dx.doi.org/10.1123/jlas.4.2.72.

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Chontos, Ashley, Joseph M. Akana Murphy, Mason G. MacDougall, et al. "The TESS-Keck Survey: ^* Science Goals and Target Selection." Astronomical Journal 163, no. 6 (2022): 297. http://dx.doi.org/10.3847/1538-3881/ac6266.

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Abstract The Kepler and TESS missions have demonstrated that planets are ubiquitous. However, the success of these missions heavily depends on ground-based radial velocity (RV) surveys, which combined with transit photometry can yield bulk densities and orbital properties. While most Kepler host stars are too faint for detailed follow-up observations, TESS is detecting planets orbiting nearby bright stars that are more amenable to RV characterization. Here, we introduce the TESS-Keck Survey (TKS), an RV program using ∼100 nights on Keck/HIRES to study exoplanets identified by TESS. The primary

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