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Journal articles on the topic 'Inc Daily Racing Form'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Setya Tumewu, Maria Clara Irsa, and Nani Kurniasari. "MOTIF DAN KEPUASAN KOMUNITAS ACID PADA MEDIA SOSIAL DISCORD SEBAGAI SARANA PEMENUHAN KEBUTUHAN INFORMASI." Jurnal Pustaka Komunikasi 5, no. 1 (2022): 25–37. http://dx.doi.org/10.32509/pustakom.v5i1.1680.

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Computer Mediated Communication encourages the formation of virtual communities in the new media era. The shift in communication patterns to become more effective and efficient is one of the advantages that can be felt through the presence of the Internet in the daily life of its users. Discord as the main medium for exchanging information for members of the Indonesian Autoclutch community, specifically discusses sim racing or virtual racing which is in great demand by various social, economic, and age groups. Thus, the existence of Discord as a means of fulfilling information needs that has b

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MacLeay, Jennifer M., Sandy A. Sorum, Stephanie J. Valberg, Will E. Marsh, and Mike D. Sorum. "Epidemiologic analysis of factors influencing exertional rhabdomyolysis in Thoroughbreds." American Journal of Veterinary Research 60, no. 12 (1999): 1562–66. http://dx.doi.org/10.2460/ajvr.1999.60.12.1562.

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Abstract Objective To determine incidence, effect on performance, and management practices associated with exertional rhabdomyolysis (ER) in Thoroughbreds. Sample Population Medical records for 984 Thoroughbreds and a survey of trainers of horses with and without ER. Procedures Medical records for 984 Thoroughbreds stabled at a midwestern racetrack were examined to determine the incidence of ER during the 1995 racing season. A retrospective questionnaire was administered to trainers to determine management practices associated with ER in 59 Thoroughbreds with ER and 47 control Thoroughbreds in

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Batsaikhan, Javzandulam, and Candace Kaye. "Horse Racing With Sheep Ankle Bones: The Play of Nomadic Children in Mongolia." Journal of Childhood Studies 42, no. 3 (2017): 40. http://dx.doi.org/10.18357/jcs.v42i3.17893.

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<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><span>The play activities of nomadic Mongolian children embrace an ancient traditional philosophy of life, connecting families to nature, respecting elders, and encouraging tenacity in daily life. This article discusses the context of this unique form of child play, its meaning, and its functional value. The major focus is on how these play activities have been communicated through centuries within themes of survival, lifestyle, and story. The article first r

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Hamilton, R. M. G., and J. Kennie. "The effects of lighting program, ingredient particle size and feed form on the performance of broiler turkeys." Canadian Journal of Animal Science 77, no. 3 (1997): 503–8. http://dx.doi.org/10.4141/a97-028.

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Two experiments were done to examine the effects of lighting program, ingredient particle size and feed form on the performance of female and male medium White turkey broilers. The poults (1200 initially of each sex) were randomly assigned, within sexes, among 48 floor pens (4.83 × 2.95 m; initially 50 birds each) located in a light-tight house. The treatments were distributed among the pens according to a 3 × 2 × 4 factorial arrangement that contained three lighting programs (four cycles daily of 4L:2D [INT]; 6L:18D at 3 d gradually increasing to 22L:2D at 77 d [INC]; and INC with a 1-h light

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Kathiravan, P., D. K. Sadana, B. P. Mishra, et al. "Survey and characterization of South Kanara buffaloes in India." Animal Genetic Resources Information 43 (April 2008): 67–77. http://dx.doi.org/10.1017/s1014233900002741.

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SummaryKanarese buffaloes are medium built animals distributed in the South Kanara region on the west coast of South India. These buffaloes are dual purpose animals used mainly for agricultural operations in wet fields and for some milk production. They are famous for racing in water-bound fields. South Kanara buffaloes are moderate milk yielders producing about two to seven litres daily for a lactation period that ranged between 210 to 360 days. Genetic diversity analysis was performed using 10 microsatellite markers in a panel of 48 unrelated animals. The average number of alleles was estima

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Li, Sui Kwong, Erin K. McCreary, Erin K. McCreary, et al. "101. Impact of an Integrated Tele-Antimicrobial Stewardship Program at a Rural Community Hospital." Open Forum Infectious Diseases 8, Supplement_1 (2021): S164—S165. http://dx.doi.org/10.1093/ofid/ofab466.303.

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Abstract Background Small hospitals in the US may lack access to infectious diseases (ID) expertise despite similar rates of antimicrobial use and drug-resistant bacteria as larger hospitals. A tele-antimicrobial stewardship program (TASP) is a force multiplier, expanding access to specialty care, training, and guidance on appropriate resource utilization. Data on the impact of TASPs in community or rural inpatient settings is limited. Methods We established a TASP at a 160-bed hospital in Armstrong County, PA (population &lt; 5000) in September 2020. Tele-ID consult services were already

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Citera, G., R. Jain, F. Irazoque-Palazuelos, et al. "THU0196 TOFACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS AND INDICATIVE OF DEPRESSION AND/OR ANXIETY: A POST HOC ANALYSIS OF PHASE 3 AND PHASE 3B/4 CLINICAL TRIALS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 318–19. http://dx.doi.org/10.1136/annrheumdis-2020-eular.417.

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Background:Depression/anxiety are common in RA pts. SF-36 MCS ≤38 can identify probable major depressive disorder and/or probable generalised anxiety disorder (pMDD/pGAD) in RA pts. Tofacitinib is an oral JAK inhibitor for the treatment of RA.Objectives:To assess pMDD/pGAD prevalence in the tofacitinib RA program and efficacy by baseline (BL) pMDD/pGAD status.Methods:Data from pts receiving tofacitinib, ADA, or PBO were pooled from 5 Phase (P)3 and 1 P3b/4 trials. Demographics/BL characteristics were reported by BL pMDD/pGAD (SF-36 MCS ≤38, presence; >38, absence). Month (M)3/6/9/12 SF-36 M

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Ritchlin, C. T., A. Ogdie, J. T. Giles, et al. "AB0827 IMPACT OF BASELINE BODY MASS INDEX ON THE EFFICACY AND SAFETY OF TOFACITINIB IN PATIENTS WITH PSORIATIC ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1717.2–1718. http://dx.doi.org/10.1136/annrheumdis-2020-eular.993.

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Background:Obesity is highly prevalent in PsA (~45%)1and is associated with a reduced response to TNF inhibitors.2Tofacitinib is an oral Janus kinase inhibitor for the treatment of PsA.Objectives:This post hoc analysis assessed tofacitinib efficacy and safety in patients (pts) with PsA by baseline (BL) body mass index (BMI) category.Methods:Data were pooled from two placebo (PBO)-controlled, double-blind, Phase 3 studies in pts with active PsA and an inadequate response to ≥1 conventional synthetic DMARD (OPAL Broaden [12 months;NCT01877668]) or to ≥1 TNF inhibitor (OPAL Beyond [6 months;NCT01

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Vinayachandra and Prasad K. Krishna. "IoT Solutions Industry Prospects Analysis with Specific Reference to Mobiloitte Inc." International Journal of Case Studies in Business, IT, and Education (IJCSBE) 4, no. 1 (2020): 63–77. https://doi.org/10.5281/zenodo.3766919.

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Life is made easy by a rising technology, the Internet of Things, which promised transformation in the way we work, we live, we play, we analyze and we think. The influence of IoT is seen everywhere today, from consumer products to military equipment, from motorbikes to airplanes, from manufacturing units to industries, and from daily use items to utility components and from house to smart cities. The everyday use objects which are being combined with Internet connection and data analytics capabilities guarantee ease of doing work, ease of living, ease of analyzing, ease of thinking and ease o

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Navarro-Compán, V., J. C. C. Wei, F. Van den Bosch, et al. "POS0895 EFFECT OF TOFACITINIB ON PATIENT-REPORTED OUTCOMES IN PATIENTS WITH ACTIVE ANKYLOSING SPONDYLITIS: RESULTS FROM A PHASE 3 TRIAL." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 704.1–704. http://dx.doi.org/10.1136/annrheumdis-2021-eular.106.

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Background:Ankylosing spondylitis (AS) can significantly impact quality of life. Tofacitinib is an oral Janus kinase inhibitor under investigation for the treatment of adult patients (pts) with AS. The safety/efficacy (including pt-reported outcomes [PROs]) of tofacitinib in pts with AS was assessed in a Phase 3 trial (NCT03502616).1Objectives:To evaluate the effect of tofacitinib on pt-reported pain, fatigue, overall health and work productivity in pts with active AS enrolled in the Phase 3 trial.Methods:Pts with an inadequate clinical response or intolerance to ≥2 oral NSAIDs were randomised

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Zahrah, Wahyuni, and Ridho Adjie Pangestu. "Reconstruction and Development of Tourism Potentials in the Fishermen’s District Village of Medan Belawan." International Journal of Architecture and Urbanism 2, no. 2 (2018): 157–67. http://dx.doi.org/10.32734/ijau.v2i2.401.

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Belawan Fishermen Village is a Fisherman Village on the edge of Medan City. The fisherman is the biggest livelihood in this village. A Spatial also has a lot of activities / local wisdom as well as traditions such as traditional rowing racing, drying salted fish and catching fish. The problems of the Villages are from poverty, lack of green open space, dirty and smelly environments, waste everywhere, improper laying of buildings, and inadequate water supply. The structures of buildings and building materials in these villages are also included in the inappropriate category. This design aims to

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Murphy, Elizabeth J., Donna Neuberg, Kanti R. Rai, et al. "Kinetic Measurement of Leukemia-Cell Proliferation Rate By Deuterium Labeling Predicts Time to Initial Treatment of Patients with Chronic Lymphocytic Leukemia." Blood 124, no. 21 (2014): 829. http://dx.doi.org/10.1182/blood.v124.21.829.829.

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Abstract Background: Chronic lymphocytic leukemia (CLL) patients exhibit variable times from diagnosis to the need to initiate therapy. Previous studies have demonstrated that the rates of CLL cell proliferation (birth) and elimination (death plus recirculation to solid tissues) could be estimated using the incorporation of deuterium (2H), taken in the form of heavy water (2H2O), into the DNA of dividing cells. In a cross-sectional study of patients with early and late stage CLL, birth rates above 0.35% per day were associated with more aggressive disease. The NIH-sponsored CLL Research Consor

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Lomenick, Adam, Sandy Kuhlman, Tami Gurley-Calvez, et al. "Economics of using telehospice to supplement hospice care in rural areas." Journal of Clinical Oncology 37, no. 15_suppl (2019): 11535. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.11535.

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11535 Background: Hospice care in rural areas is often characterized by provider shortages and vast geographical service areas to cover, making access to quality end-of-life care challenging. Telehospice, the utilization of interactive video (ITV) technology to provide health services over a distance for hospice patients, has been proposed as a solution to address access issues. In 2017, the University of Kansas Medical Center (Kansas City, Kansas) partnered with Hospice Services, Inc. (HSI) (Phillipsburg, Kansas) to augment traditional, in-person hospice care with hospice care delivered via m

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Schuster, Michael W., Mikkael A. Sekeres, Erick Gamelin, et al. "Phase 1 Study of AMG 900, an Orally Administered Pan-Aurora Kinase Inhibitor, in Adult Patients (Pts) with Acute Myeloid Leukemia (AML)." Blood 126, no. 23 (2015): 4929. http://dx.doi.org/10.1182/blood.v126.23.4929.4929.

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Abstract Background: Aurora kinases form a family of highly conserved serine/threonine protein kinases that regulate key steps in mitosis. Aurora kinases A and B are amplified and/or overexpressed in many malignancies, including various types of leukemia, and are associated with high proliferation rates, poor prognosis, and therapeutic resistance. AMG 900 is an investigational, orally administered, highly potent, selective, small-molecule pan-aurora kinase inhibitor that has shown single-agent activity in heavily pretreated pts with chemotherapy-resistant/refractory solid tumors. This open-lab

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Rahman, Farah, Marilyn de Chantal, Pedro Mesquita, and Judith A. Aberg. "935. Effect of Tesamorelin in People with HIV with and without Dorsocervical Fat: Post Hoc Analysis of Phase III Double Blind Placebo Control Trial." Open Forum Infectious Diseases 7, Supplement_1 (2020): S500—S501. http://dx.doi.org/10.1093/ofid/ofaa439.1121.

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Abstract Background Lipohypertrophy is defined as excess fat deposition in abdominal defined as visceral adipose tissue (VAT) as well as in the dorsocervical region, breasts, trunk, and along with possible fat deposition in liver, muscle, myocardium and epicardium. Multiple factors have been described as contributing to lipohypertrophy in people living with HIV (PLWH), including patient characteristics, antiretroviral therapy (ART) and also impaired growth hormone (GH) secretion. Tesamorelin, a synthetic form of growth-hormone-releasing hormone (GHRH), is indicated for reduction of excess abdo

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Gossec, L., N. Damjanov, S. Tsuji, et al. "AB0889 Association Between Clinically Meaningful Improvements in Patient-Reported Outcomes and Stringent Measures of Disease Activity in Patients With Psoriatic Arthritis Treated With Upadacitinib Versus Placebo or Adalimumab: Results From a Phase 3 Trial." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1569–70. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1371.

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BackgroundThe achievement of disease control has been shown to be associated with improved prognosis in PsA, though no single measure of low disease activity or remission is currently universally accepted. Patient-reported outcomes (PROs) have been well-established in PsA and are important indicators of patient improvement while on treatment. To date, the association between PROs and disease control in PsA has not been fully characterized.ObjectivesWe examined the association between clinically meaningful improvement in PROs and stringent measures of disease control among patients with PsA enr

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Yang, Hongbo, Yanni Hao, Xinglei Chai, Cynthia Z. Qi, and Eric Q. Wu. "Estimation of Total Costs in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma Receiving Tisagenlecleucel from a US Hospital's Perspective." Blood 134, Supplement_1 (2019): 3419. http://dx.doi.org/10.1182/blood-2019-129070.

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INTRODUCTION: Diffuse large b-cell lymphoma (DLBCL) is a common and aggressive form of non-Hodgkin lymphoma (NHL). Relapsed/refractory (r/r) patients after two lines of therapy have limited treatment options and poor prognosis. In August 2018, tisagenlecleucel, a chimeric antigen receptor T-cell (CAR-T) therapy, received approval from the US Food and Drug Administration (FDA) for the treatment of r/r DLBCL after two or more lines of systemic therapy. Given the novel mechanism of action of tisagenlecleucel, there has been a need to understand the health resource use (HRU) and costs associated w

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Heero, Aigi. "Siirdeaegsed valupunktid kirjandusteoste peeglis: Gohar Markosjan-Käsperi romaanid "Penelopa" ja "Elena"." Philologia Estonica Tallinnensis 6 (June 1, 2021): 13–34. https://doi.org/10.22601/PET.2021.06.01.

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Gohar Markosjan-Käsper (1949–2015), an Armenian-Estonian writer, is generally considered to be a representative of Estonian Russian-language literature. Her novels “Penelopa” (1998) and “Elena” (2000) deal with a period of transition, when the Soviet Union ceased to exist and the construction of a market-oriented society began. The present study analyses how and with what techniques these novels depict the historical events and everyday life in Estonia and Armenia. The article shows how describing the history of Estonia and Armenia with universal, internation

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Schubert, Matthew M., and Elyse A. Palumbo. "Energy balance dynamics during short-term high-intensity functional training." Applied Physiology, Nutrition, and Metabolism 44, no. 2 (2019): 172–78. http://dx.doi.org/10.1139/apnm-2018-0311.

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CrossFit (CF; CrossFit Inc., Washington, DC, USA) is a form of high-intensity functional training that focuses on training across the entire spectrum of physical fitness. CF has been shown to improve a number of indicators of health but little information assessing energy balance exists. The purpose of the present study was to investigate energy balance during 1 week of CF training. Men and women (n = 21; mean ± SD; age, 43.5 ± 8.4 years; body mass index, 27.8 ± 4.9 kg·m−2), with ≥3 months CF experience, had body composition assessed via air displacement plethysmography before and after 1 week

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Maulidina and Yosafat Vitorio Simanjuntak. "Keputusan Pembelian Smartphone Yang Dipengaruhi Oleh Harga Dan Kualitas Produk." Jurnal Akuntansi, Manajemen dan Ilmu Ekonomi (Jasmien) 3, no. 02 (2023): 144–54. http://dx.doi.org/10.54209/jasmien.v3i02.373.

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It cannot be denied, the development of world technology is currently very rapid, especially the development of smartphones. Smartphones have become one of the important needs for the community, because with the existence of smartphones, people can be assisted in various activities and their daily activities. One of the well-known smartphone companies, namely Xiaomi Inc., with its product, Xiaomi. There are several reasons why people decide to buy Xiaomi, because they are influenced by competitive prices with guaranteed product quality. This study aims to determine the effect of price and prod

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Ravikrishnan, Janani, Elizabeth M. Muhowski, Tzung-Huei Lai, et al. "Characterization of LP-118, a Novel Small Molecule Inhibitor of Bcl-2 and Bcl-Xl in Chronic Lymphocytic Leukemia Resistant to Venetoclax." Blood 138, Supplement 1 (2021): 679. http://dx.doi.org/10.1182/blood-2021-151852.

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Abstract Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia, which is characterized by the accumulation of mature CD19+CD5+ B cells that evade apoptosis by upregulating anti-apoptotic BH3 protein, B cell lymphoma protein 2 (Bcl-2). Venetoclax, a first-in-class Bcl-2 inhibitor has transformed therapy for CLL. However, with continuous administration of venetoclax, patients often acquire resistance via mutations at or near the drug binding pocket at G101 in Bcl-2 (Blombery et al, Cancer Discov 2019, Lucas et al, Blood, 2020). In some patients, the acquisition of a mutati

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Gossec, L., G. Citera, A. Sellas-Fernández, D. C. Gruben, M. Valderrama, and S. Gómez. "POS1025 TOFACITINIB TREATMENT IN PATIENTS WITH PSORIATIC ARTHRITIS AND PROBABLE DEPRESSION AND/OR ANXIETY: A POST HOC ANALYSIS OF TWO PHASE 3 CLINICAL TRIALS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 782.1–782. http://dx.doi.org/10.1136/annrheumdis-2021-eular.176.

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Background:Depression and anxiety are highly prevalent in patients (pts) with psoriatic arthritis (PsA),1 with inflammation a key pathogenic feature of depression in these pts.2 Tofacitinib is an oral Janus kinase inhibitor for the treatment of PsA. It acts by modulating immune and inflammatory responses. The link between major depressive disorder/generalised anxiety disorder (MDD/GAD), inflammation and tofacitinib effectiveness has not been fully explored.Objectives:Analyse the prevalence of probable MDD/GAD in pts with PsA initiating tofacitinib treatment and the impact of baseline (BL) prob

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Steis, R. G., W. J. Urba, L. A. VanderMolen, et al. "Intraperitoneal lymphokine-activated killer-cell and interleukin-2 therapy for malignancies limited to the peritoneal cavity." Journal of Clinical Oncology 8, no. 10 (1990): 1618–29. http://dx.doi.org/10.1200/jco.1990.8.10.1618.

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Autologous lymphokine-activated killer (LAK) cells and recombinant human interleukin-2 (rIL-2) were administered intraperitoneally (IP) to 24 patients with malignancies limited to the peritoneal space. Ten patients had ovarian cancer, 12 had colorectal cancer, and one patient each had endometrial carcinoma and primary small-bowel adenocarcinoma. All ovarian cancer patients, three of twelve colorectal cancer patients, and one patient with endometrial carcinoma had received prior therapy. Patients received IL-2 100,000 U/kg every 8 hours intravenously (IV) for 3 days, and 2 days later underwent

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Pasternak, Marcin, and Jarosław Woroń. "Buffering of injectable local anaesthesia solution in dentistry –theory and practice. Chair-side methods of alkalinization." BÓL 26, no. 1 (2025): 42–49. https://doi.org/10.5604/01.3001.0055.1224.

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Local anaesthetics constitute the pharmacological basis of dental practice. In solutions for injection, local anaestheticsare present in two forms: cationic (ionised) and basic (unionised), which are in dynamic equilibrium depending on the prevailing reaction. Preparations, especially those with the addition of a vasoconstrictor, are characterised by low pHvalues of up to 3–3.5. The acidic nature of the formulations extends their shelf life, but is associated with a burningsensation during their administration and, resulting from the increased concentration of the ionised form, a longerlatency

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Oh, Stephen T., Moshe Talpaz, Aaron T. Gerds, et al. "Hepcidin Suppression By Momelotinib Is Associated with Increased Iron Availability and Erythropoiesis in Transfusion-Dependent Myelofibrosis Patients." Blood 132, Supplement 1 (2018): 4282. http://dx.doi.org/10.1182/blood-2018-99-111349.

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Abstract Introduction: Patients develop anemia as a result of myelofibrosis (MF) or its treatment, including Janus kinase (JAK) inhibitors. However, momelotinib (MMB), a JAK1/2 and Activin A receptor type I (ACVR1) inhibitor with demonstrated clinical activity in MF, improved anemia in prior clinical trials. JAK1/2 and ACVR1 respond to inflammation and iron stores to control iron availability through hepcidin, the key regulator of the entry of iron into circulation. Like other inflammatory diseases, MF is characterized by high hepcidin. MMB inhibited ACVR1 to modulate hepcidin and ameliorate a

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Tran, David T., Mark E. Hayes, Charles O. Noble, Zhipeng Dai, Peter K. Working, and Francis C. Szoka. "Twice Monthly Liposome Encapsulated Deferoxamine (LDFO) Has a High Molar Efficiency in Removing Total Body Iron in an Iron Dextran-Overloaded Mouse Model." Blood 128, no. 22 (2016): 2322. http://dx.doi.org/10.1182/blood.v128.22.2322.2322.

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Abstract Introduction: Patients who have β-thalassemia, sickle cell anemia, and myelodysplastic syndromes are sustained by long-term blood transfusion therapy. Transfusion therapy results in iron accumulation initially in the liver, spleen and bone marrow. These are the organs responsible for eliminating apoptotic red blood cells. To prevent iron overload, iron must be removed using iron chelators, administered either orally or infused on a daily basis. One strategy to more effectively deliver chelators to the sites of iron accumulation is to encapsulate them in liposomes. Liposomes also accum

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Kulikov, Dmitry Ye. "Review of: Adam C. Schwartz. The Oracle Bone Inscriptions from Huayuanzhuang East. Boston/Berlin: Walter de Gruyter Inc., 2019. Divinatory Inscriptions from the Eastern Sector of Huayuanzhuang in Yinxu." Oriental Courier, no. 4 (2022): 229. http://dx.doi.org/10.18254/s268684310023835-6.

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This review considers the book of the American sinologist A. Schwartz “The Oracle Bone Inscriptions from Huayuanzhuang East. Translated with an Introduction and Commentary” was published in 2019. The book is a commented translation and study of inscriptions on divination bones (turtle shields and bull shoulder blades) from the eastern sector of Huayuanzhuang in Yinxu (Anyang, Henan). This epigraphic monument dates back to the turn of the 13th–12th centuries BC and currently represents the most complete and interesting corpus of divinatory inscriptions. Despite the fact that the inscriptions un

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Kachlany, Scott C., Amy Le, and Benjamin A. Belinka. "Leukotoxin (Leukothera™), a Targeted Therapy for Hematological Malignancies." Blood 116, no. 21 (2010): 3284. http://dx.doi.org/10.1182/blood.v116.21.3284.3284.

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Abstract Abstract 3284 Leukotoxin (Leukothera™) is a bacterial protein toxin that naturally targets and kills disease associated white blood cells (WBCs) expressing the activated form of leukocyte function antigen-1 (LFA-1). While leukotoxin has minimal effects on resting and healthy cells, it causes significant death of malignant WBCs associated with leukemias and lymphomas. Leukotoxin is a unique biologic in that it already provides both toxicity and specificity without requiring fusion of the protein to other molecules such as antibody fragments or cytokines. In vivo efficacy was demonstrat

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Chen, Zheng, Dongming Tan, Wenjun Zhao, et al. "Cellular Intrinsic Mechanism Affecting The Outcome Of AML Treatment With Ara-C In a Syngeneic Mouse Model." Blood 122, no. 21 (2013): 5025. http://dx.doi.org/10.1182/blood.v122.21.5025.5025.

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Abstract Acute myeloid leukemia (AML) is a deadly form of hematologic malignancy. Refractoriness to treatment in AML represents a common reason for treatment failure. However, the underlying biological mechanisms are not clear. Mouse models of types of leukemia have proved valuable in the identification of mechanisms responsible for leukemogenesis and in the evaluation of efficacy of therapeutics. In this work, we established and characterized a mouse model of AML, by transplantation of BXH-2 derived myeloid leukemic cells into syngeneic mice. The recipient mice developed leukemia shortly foll

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Raj, Saroj Vadhan, Andrew Hsieh, William Strauss, Michael Stevenson, Kristine Bernard, and Lee F. Allen. "Ferumoxytol Treatment Demonstrates Significant Improvements in Fatigue and Health-Related Quality of Life in Iron Deficiency Anemia Patients with a History of Unsatisfactory Oral Iron Therapy." Blood 120, no. 21 (2012): 478. http://dx.doi.org/10.1182/blood.v120.21.478.478.

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Abstract Abstract 478 Introduction: Iron is essential for the function of many key proteins including hemoglobin (Hgb) and myoglobin (involved in oxygen transport/exchange), cytochromes (involved in energy generation), various enzymes (involved in cell proliferation and neurotransmission), and immune function. Iron deficiency can, therefore, negatively impact patients' health-related quality of life (HRQL) and requires treatment to replete iron stores. Although oral iron is a common initial treatment, some patients do not tolerate it or fail to adequately respond; many of these patients, there

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Deloney, Marcus A., Kyra Smart, Blaine Christiansen, and Alyssa Panitch. "4260 Hollow, Degradable poly(N-Isopropylacrylamide) Derived Nanoparticles for the Delivery of Anti-Inflammatory Peptides for the Treatment and Prevention of Post-Traumatic Osteoarthritis." Journal of Clinical and Translational Science 4, s1 (2020): 109. http://dx.doi.org/10.1017/cts.2020.334.

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OBJECTIVES/GOALS: Knocking down the inflammatory response following joint trauma may halt the cytokine cascade and prevent the resulting cyclic degradation of articular cartilage. MK2 inhibiting (MK2i) peptides are an emerging and promising class of pharmaceutical to treat post-traumatic osteoarthritis (PTOA); however, these peptides are susceptible to proteolytic degradation in the extracellular space. Our objective is to encapsulate MK2i in thermoresponsive hollow nanoparticles (hNPs) to knockdown the inflammatory cytokine IL-6 to prevent the cyclic degradation of articular cartilage. METHOD

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Miraj, Sepideh, Maryam Derakhshani, Abolfazl Mohammadbeigi, Fatemeh Hassanzadeh, Fatemeh Ramezani, and Mohammad Aligol. "Premenstrual Disorders (PMS and PMDD) Incidence, and its Predictors in Iranian Medical University Students; An Exploratory Cross Sectional Study." Ethiopian Journal of Reproductive Health 15, no. 4 (2023): 10. http://dx.doi.org/10.69614/ejrh.v15i4.687.

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Introduction: Premenstrual disorders are a wide range of physical, behavioral, and psychological symptoms which emergence before menstruation and in the first initial days of menstruation which repeat in several cycle. This study aimed to evaluate the Premenstrual syndrome (PMS) and Premenstrual dysphoric disorder (PMDD) incidence and its related factors among Iranian medical students. Materials and Methods: In a is cross sectional study 264 students of Qom university of Medical Sciences were selected by stratified proportional to size and simple random sampling method. Demographic form, Preme

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Garcia-Manero, Guillermo, Olatoyosi Odenike, Philip C. Amrein, et al. "Successful Emulation of IV Decitabine Pharmacokinetics with an Oral Fixed-Dose Combination of the Oral Cytidine Deaminase Inhibitor (CDAi) E7727 with Oral Decitabine, in Subjects with Myelodysplastic Syndromes (MDS): Final Data of Phase 1 Study." Blood 128, no. 22 (2016): 114. http://dx.doi.org/10.1182/blood.v128.22.114.114.

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Abstract Introduction: Patients with International Prognostic Scoring System (IPSS) intermediate 1 and 2 (Int) and high risk (HR) MDS benefit from therapy with hypomethylating agents (HMAs) decitabine (DAC) and azacitidine (AZA). Treatment requires 5 or 7 daily parenteral doses every month while the patient is benefitting. An oral HMA taken at home would provide patient convenience, and potentially enhance adherence to treatment particularly for long-term responders. Neither DAC nor AZA is readily bioavailable in oral form due to rapid clearance by cytidine deaminase (CDA) present in the gut a

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Lal, Ashutosh, R. Clark Clark Brown, Thomas D. Coates, et al. "Trial in Progress: A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of the PKR Activator Etavopivat (FT-4202) in Patients with Thalassemia or Sickle Cell Disease." Blood 138, Supplement 1 (2021): 4162. http://dx.doi.org/10.1182/blood-2021-145752.

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Abstract Background Sickle cell disease (SCD) and thalassemia are inherited hemoglobinopathies characterized by lifelong anemia. In SCD, a single mutation in the β-globin gene results in sickle hemoglobin (HbS) that polymerizes upon deoxygenation, causing red blood cells (RBCs) to sickle leading to a variety of complications. In thalassemia, mutation(s) in α- or β-globin genes result in reduced or absent adult Hb causing ineffective erythropoiesis and downstream complications. The resultant anemias are exacerbated by impaired RBC function due to decreased ATP content. Supportive care and agent

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Lohman, Robert, Vijayvel Jayaprakash, Amir Dorafshar, Lawrence Gottlieb, and Mieczyslawa Franczyk. "Evolving techniques for negative pressure wound therapy and the value of grass roots comparative effectiveness research." Journal of Clinical Oncology 31, no. 31_suppl (2013): 160. http://dx.doi.org/10.1200/jco.2013.31.31_suppl.160.

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160 Background: There is debate over the value of comparative effectiveness research to address national health problems, but less attention has focused on its value to solve smaller questions. We present an example of local, clinician initiated, and unfunded comparative effectiveness research to address problems related to negative pressure wound therapy (NPWT) at our hospital. NPWT was popularized as the VAC (Vacuum Assisted Closure, Kinetic Concepts, Inc., San Antonio, TX) system and became standard treatment for many inpatient wounds. Between 2000 and 2006, VAC was the only form of NPWT at

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Savona, Michael R., Olatoyosi Odenike, Philip C. Amrein, et al. "Results of First in Human (FIH) Phase 1 Pharmacokinetic (PK) Guided Dose-Escalation Study of ASTX727, a Combination of the Oral Cytidine Deaminase Inhibitor (CDAi) E7727 with Oral Decitabine in Subjects with Myelodysplastic Syndromes (MDS)." Blood 126, no. 23 (2015): 1683. http://dx.doi.org/10.1182/blood.v126.23.1683.1683.

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Abstract Introduction: Patients with International Prognostic Scoring System (IPSS) intermediate (Int) and high risk (HR) MDS benefit from therapy with hypomethylating agents (HMAs). Treatment with the HMAs decitabine (DAC) and azacitidine (AZA) requires 5 or 7 daily parenteral doses respectively every month with some patients remaining on treatment for extended periods. An orally administered HMA would provide significant patient convenience, potentially enhance adherence to treatment, and may allow exploring extended treatment schedules with lower doses of DAC. Neither DAC nor AZA is readily

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Conlin, Emily, Herbert Lardner, Jennifer L. Ellis, Ira B. Mandell, and Katharine M. Wood. "PSVII-13 Performance and environmental benefits from biochar supplementation in beef cattle grazing systems." Journal of Animal Science 99, Supplement_3 (2021): 448–49. http://dx.doi.org/10.1093/jas/skab235.799.

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Abstract Worldwide, beef production systems represent a significant source of greenhouse gas (GHG), and enteric methane (CH4) emissions are the primary concern. The objective of this experiment was to determine whether biochar (Oregon Biochar Solution, White City, OR) supplementation can reduce CH4 emissions from grazing beef cows. Biochar is a stable form of carbon produced through the pyrolysis of organic matter (typically forestry waste). Sixty-four cows and their calves were blocked by cow body weight and calf age, and randomly allocated to 8 paddocks, each with 8 cow-calf pairs. Using a c

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Conlin, Emily, Herbert Lardner, Jennifer L. Ellis, Ira B. Mandell, and Katharine M. Wood. "PSXIV-7 Performance and environmental benefits from biochar supplementation in beef cattle grazing systems." Journal of Animal Science 99, Supplement_3 (2021): 475–76. http://dx.doi.org/10.1093/jas/skab235.838.

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Abstract Reducing greenhouse gas (GHG) emissions from beef cattle production systems has continuously been recognized as an important strategy to help mitigate climate change. This experiment was conducted to determine the optimum inclusion level of biochar (Oregon Biochar Solution, White City, OR) in the diet to reduce enteric methane (CH4) emissions from beef cows. Biochar is a stable form of carbon produced through low-oxygen and high-temperature pyrolysis of organic matter (typically forestry waste). Using a 4 x 4 Latin square design, pregnant beef cows (n = 8) of similar weight and stage

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Jiang, Shibo, Hong Lu, Shuwen Liu, Qian Zhao, Yuxian He, and Asim K. Debnath. "N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion." Antimicrobial Agents and Chemotherapy 48, no. 11 (2004): 4349–59. http://dx.doi.org/10.1128/aac.48.11.4349-4359.2004.

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ABSTRACT A recently approved peptidic human immunodeficiency virus type 1 (HIV-1) fusion inhibitor, T-20 (Fuzeon; Trimeris Inc.), has shown significant promise in clinical application for treating HIV-1-infected individuals who have failed to respond to the currently available antiretroviral drugs. However, T-20 must be injected twice daily and is too expensive. Therefore, it is essential to develop orally available small molecule HIV-1 fusion inhibitors. By screening a chemical library consisting of “drug-like” compounds, we identified two N-substituted pyrroles, designated NB-2 and NB-64, th

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Verstovsek, Srdan, Moshe Talpaz, Ellen K. Ritchie, et al. "A Phase 1/2, Open-Label, Dose-Escalation, Multi-Center Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Orally Administered NS-018 in Patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (postPV MF), or Post-Essential Thrombocythemia Myelofibrosis (postET MF)." Blood 124, no. 21 (2014): 1839. http://dx.doi.org/10.1182/blood.v124.21.1839.1839.

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Abstract Background: NS-018 is an oral, selective, small molecule inhibitor of Janus kinase 2 (JAK2). Pre-clinically NS-018 inhibited JAK2 kinase with an IC50 value in the subnanomolar range and demonstrated splenomegaly reduction at low doses in a JAK2V617F-bearing mouse model (Blood Cancer J 2011; 1: e29.). Methods: This multicenter, Phase 1/2, 3+3 dose-escalation study of NS-018 enrolled patients with IPSS intermediate-1, intermediate-2, or high risk PMF, postPV MF, or postET MF. Patients were ≥ 18 years, had ECOG PS ≤ 2 and required therapy but were not required to have splenomegaly in Pha

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Gafni, Rachel Ilana, Iris Ruth Hartley, Kelly Lauter Roszko, et al. "A Phase 2B, Open-Label, Dose-Ranging Study of Encaleret (CLTX-305) in Autosomal Dominant Hypocalcemia Type 1 (ADH1)." Journal of the Endocrine Society 5, Supplement_1 (2021): A253—A254. http://dx.doi.org/10.1210/jendso/bvab048.515.

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Abstract Autosomal dominant hypocalcemia type 1 (ADH1) is a rare form of hypoparathyroidism caused by gain-of-function pathogenic variants in the gene encoding the calcium-sensing receptor (CaSR). It is characterized by variable degrees of hypocalcemia, hyperphosphatemia, and hypomagnesemia, with inappropriately low levels of parathyroid hormone (PTH) and hypercalciuria. Conventional therapy includes oral calcium and activated Vitamin D supplementation, which can lead to or exacerbate hypercalciuria. As a result, patients may develop nephrolithiasis and/or nephrocalcinosis, which can progress

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Kitazawa, Satoshi, Yukiko Ishii, Keiko Makita-Suzuki, et al. "Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells." Blood 134, Supplement_1 (2019): 2663. http://dx.doi.org/10.1182/blood-2019-121869.

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Cancer initiating cells (CIC) are suggested to be responsible for drug resistance and cancer relapse that are associated with poor prognosis. Therefore, drugs effective for CIC could fulfill an unmet clinical need. We performed a drug screen with chemical libraries to find out new compounds which specifically eradicated CIC established in the previous report (Yamashita et al., Cancer Research, 2015). We obtained compounds with a carboxylic acid skeleton as hit compounds. Interestingly, FF1215T, one of the hit compounds, was shown to inhibit growths of CIC by decreasing intracellular pyrimidine

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Harrison, Claire N., Nicolaas PM Schaap, Sonja Zweegman, et al. "Efficacy and Safety Of Fedratinib (SAR302503/TG101348) In Patients With Intermediate- Or High-Risk Myelofibrosis (MF), Post-Polycythemia Vera (PV) MF, Or Post-Essential Thrombocythemia (ET) MF Previously Treated With Ruxolitinib: Interim Results From a Phase II Study (JAKARTA-2)." Blood 122, no. 21 (2013): 661. http://dx.doi.org/10.1182/blood.v122.21.661.661.

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Abstract Background The JAK1/JAK2 inhibitor ruxolitinib (RUX) is approved for treatment of myelofibrosis (MF). However, some patients do not respond to RUX, while others lose responsiveness or develop intolerance to RUX over time. Preclinical data also suggest that certain JAK2 mutations (eg the gatekeeper mutation M929I) may confer resistance to RUX (Leukemia 2012;26:708). Options for these RUX resistant/intolerant patients, particularly with regard to further JAK inhibitor therapy, are unclear. Fedratinib (SAR302503) is a JAK2-selective inhibitor which has demonstrated clinically meaningful

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Paprocki, A. M., C. M. Syverson, R. W. Koppang, and J. R. Dobrinsky. "123 LONG-TERM PRODUCTION OF IN VITRO-MATURED PORCINE OOCYTES AND EMBRYOS." Reproduction, Fertility and Development 21, no. 1 (2009): 161. http://dx.doi.org/10.1071/rdv21n1ab123.

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Although in vivo matured, ovulated, or both, oocytes provide the finest genetic material for use in assisted reproductive technologies (ART), their en masse production requires livestock production facilities, staff and associated overhead, is expensive and labor intensive, their harvest involves surgical or laparoscopic expertise, and large yields needed for en masse daily embryo production are cumbersome and very costly. In vitro-matured (IVM) oocytes have long been a practical gamete source for ART, including in vitro fertilization, ICSI and cloning. Rather than using conventional IVF to pr

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Vadhan-Raj, Saroj, Naomi V. Dahl, John Jiang, and William E. Strauss. "Sustained Improvements in Fatigue and Quality of Life in Iron Deficiency Anemia Patients Following a Single Course of Ferumoxytol: Results of a 6-Month Extension Study." Blood 132, Supplement 1 (2018): 1050. http://dx.doi.org/10.1182/blood-2018-99-115511.

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Abstract Introduction: Iron is essential for the function of many key proteins including hemoglobin (Hgb) and myoglobin (involved in oxygen transport/exchange), cytochromes (involved in energy generation), various enzymes (involved in cell proliferation and neurotransmission), and immune function. Iron deficiency can, therefore, negatively impact patients' health-related quality of life (HRQOL) and requires treatment to replete iron stores. Although oral iron is a common initial treatment, some patients do not tolerate it or fail to adequately respond, and many of these patients live with chro

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Byrne, Laurann, Stephen Ross, Jules Taylor-Pickard, and Richard Murphy. "The Effect of Organic Trace Mineral Supplementation in the Form of Proteinates on Performance and Sustainability Parameters in Laying Hens: A Meta-Analysis." Animals 13, no. 19 (2023): 3132. http://dx.doi.org/10.3390/ani13193132.

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The effect of supplementing organic trace minerals (OTM), in the form of mineral proteinates (Bioplex® Cu, Fe, Mn, and Zn, Alltech Inc., Nicholasville, KY, USA), in the diets of laying hens was examined using Comprehensive Meta-Analysis (CMA) statistical software. The impact on production performance, egg quality traits, and sustainability parameters related to the carbon footprint of egg production was assessed. Data were obtained from 32 global studies, comprising 107 dietary assessments of 30,992 laying hens. Overall pooled effect size (raw mean difference) of production performance when di

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Moyo, Tamara K., Andrew Sochacki, Gregory D. Ayers та ін. "Preliminary Results from a Phase I Dose Escalation Trial of Ruxolitinib and the PI3Kδ Inhibitor TGR-1202 in Myelofibrosis". Blood 128, № 22 (2016): 1125. http://dx.doi.org/10.1182/blood.v128.22.1125.1125.

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Abstract Background: Therapies for myelofibrosis (MF) are limited and most are palliative. The JAK1/2 inhibitor ruxolitinib reduces spleen size and MF-related symptoms and improves survival, but can be limited by dose-dependent anemia and thrombocytopenia. Moreover, nearly half of ruxolitinib responders relapse within 5 years. PI3Kd is highly expressed in MF patient samples, independent of ruxolitinib pre-exposure. In JAK2-mutated cell lines, inhibition of PI3K/AKT signaling reduced proliferation and clonogenic potential. The once daily, next generation PI3Kd inhibitor TGR-1202 inhibited PI3K/

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Iacono, E., L. Brunori, A. Pirrone, and B. Merlo. "384 ISOLATION OF MESENCHYMAL STEM CELLS FROM WHARTON'S JELLY, CORD BLOOD, AND AMNIOTIC FLUID IN THE HORSE." Reproduction, Fertility and Development 22, no. 1 (2010): 348. http://dx.doi.org/10.1071/rdv22n1ab384.

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The effect of orthopedic injuries on the health of racehorse and racing financials can be dramatic. Bearing this in mind, there is naturally a great interest in new possible treatments for orthopedic injuries. In this study we evaluated equine amniotic fluid (AF), cord blood (CB), and Wharton’s jelly (WJ) as alternative sources of primitive, multipotent stem cells. All chemicals were obtained from Sigma-Aldrich (St. Louis, MO, USA) unless otherwise stated. Samples were recovered at labor from 7 standardbred mares with ages between 6 and 15 years. Wharton’s jelly was incubated with collagenasis

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Bott, Nicholas, Sharon Wexler, Lin Drury, et al. "A Protocol-Driven, Bedside Digital Conversational Agent to Support Nurse Teams and Mitigate Risks of Hospitalization in Older Adults: Case Control Pre-Post Study." Journal of Medical Internet Research 21, no. 10 (2019): e13440. http://dx.doi.org/10.2196/13440.

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Background Hospitalized older adults often experience isolation and disorientation while receiving care, placing them at risk for many inpatient complications, including loneliness, depression, delirium, and falls. Embodied conversational agents (ECAs) are technological entities that can interact with people through spoken conversation. Some ECAs are also relational agents, which build and maintain socioemotional relationships with people across multiple interactions. This study utilized a novel form of relational ECA, provided by Care Coach (care.coach, inc): an animated animal avatar on a ta

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Zinzani, Pier Luigi, Felipe Samaniego, Wojciech Jurczak та ін. "Umbralisib, the Once Daily Dual Inhibitor of PI3Kδ and Casein Kinase-1ε Demonstrates Clinical Activity in Patients with Relapsed or Refractory Indolent Non-Hodgkin Lymphoma: Results from the Phase 2 Global Unity-NHL Trial". Blood 136, Supplement 1 (2020): 34–35. http://dx.doi.org/10.1182/blood-2020-134851.

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Background: Umbralisib is an oral, once-daily, dual inhibitor of phosphatidylinositol-3-kinase-delta (PI3Kδ) and casein kinase-1ε (CK1ε) that exhibits improved selectivity for the delta isoform of PI3K. The UNITY-NHL trial (NCT02793583) is a multicenter, open-label, registration directed Phase 2 study designed to evaluate the safety and efficacy of umbralisib in previously treated NHL patients (pts). Previously reported results in pts with relapsed/refractory (R/R) marginal zone lymphoma (MZL) demonstrated that umbralisib was active with a manageable safety profile. In contrast with other PI3K

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