Academic literature on the topic 'Inc TNS'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Inc TNS.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Inc TNS"
1
Luo, Peng, Timothy A. DeVol, and Julia L. Sharp. "Sequential Probability Ratio Test Using Scaled Time-Intervals for Environmental Radiation Monitoring." IEEE Transactions on Nuclear Science 57, no. 6 (June 2010): 1556–62. http://dx.doi.org/10.1109/tns.2010.2045900.
Full textAbstract:
Sequential probability ratio test (SPRT) of scaled time-interval data (time to record N radiation pulses),SPRT_scaled, was evaluated against commonly used single-interval test (SIT) and SPRT with a fixed counting interval,SPRT_fixed, on experimental and simulated data. Experimental data were acquired with a DGF-4C (XIA, Inc) system in list mode. Simulated time-interval data were obtained using Monte Carlo techniques to perform a random radiation sampling of the Poisson distribution. The three methods (SIT, SPRT_fixed and SPRT_scaled) were compared in terms of detection probability and average time to make a decision regarding the source of radiation. For both experimental and simulated data, SPRT_scaled provided similar detection probabilities as other tests, but was able to make a quicker decision with fewer pulses at relatively higher radiation levels. SPRT_scaled has a provision for varying the sampling time depending on the radiation level, which may further shorten the time needed for radiation monitoring. Parameter adjustments to the SPRT_scaled method for increased detection probability are discussed.
2
Savic, Radomir, Dragan Radojkovic, Nenad Stojiljkovic, Nenad Parunovic, Marija Gogic, and Cedomir Radovic. "Effect of breed of performance tested boars on ejaculate traits." Biotehnologija u stocarstvu 36, no. 3 (2020): 309–16. http://dx.doi.org/10.2298/bah2003309s.
Full textAbstract:
The main objective of the study was to determine the influence of breed on the traits of boar ejaculate: ejaculate volume (VOL, ml), sperm concentration (CON, x106 sperm/ml), total sperm count in ejaculate (TNS, x109 spermatozoa), sperm motility in native ejaculate (MON, %), sperm motility after dilution (MOD, %) and number of doses produced (NPD). The aim was also to evaluate the correlation of the boar performance test traits: average life daily gain (g), backfat thickness measured in two locations (mm), depth of longissimus dorsi muscle (mm) and carcass meat content (%) with ejaculate traits. Total of 931 ejaculates of 36 boars during reproductive exploitation were analysed (16 Landrace boars and 20 Large White boars). The effect was assessed using the procedure of the general linear model of the statistical package SAS 9.1.3 (SAS Inst. Inc., 2002- 2003). The model for analysis included the influence of breed, season and the linear regression influence of body weight at the end of the performance test. The correlation of the traits was determined by applying the Pearson?s correlation coefficient. Most of the examined ejaculate traits (VOL, CON, MOD and NPD) varied under the influence of boar breed (p<0.01; p<0.001). Weight at the end of the test (p<0.05; p<0.01; p<0.001) affected all examined traits, except CON and TNS. A weak association was found between production performance and ejaculate traits.
3
Li, Xing, Xiaoping Wan, Zhaoxia Wang, Yanan Liang, Zhuo Jia, Xu Zhang, and Limin Liao. "Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats." International Neurourology Journal 25, no. 2 (June 30, 2021): 128–36. http://dx.doi.org/10.5213/inj.2040304.152.
Full textAbstract:
Purpose: The present study determined the effects of saphenous nerve stimulation (SNS) at different stimulation frequencies on bladder reflex and explored a possible action mechanism of tibial nerve stimulation (TNS) on bladder activity in cats.Methods: Two bipolar nerve cuff electrodes were implanted on the saphenous nerve and the contralateral tibial nerve in 13 cats, respectively. Multiple cystometrograms were obtained to determine the effects of single SNS at different frequencies and that of combined SNS and TNS on the micturition reflex by infusing normal saline.Results: SNS at 1 Hz significantly reduced the bladder capacity (BC) to 59.8%±7.7% and 59.3%±5.8% of the control level at the intensity threshold (T) and 2T, respectively (P<0.05), while that at 20 Hz significantly increased the BC to 130.6%±4.2% of the control level at 6T (P<0.05). The TNS and SNS at 20 Hz did not significantly change the BCs at 1T (P>0.05), while combined stimulation at 1T significantly increased the BC to 122.7%±1.9% of the control level and induced an inhibitory effect which was similar to that TNS at 2T.Conclusions: The current study revealed that SNS reduced and increased BC depending on different stimulation frequencies. The combined SNS and TNS maximized the clinical efficacy at a low intensity. Also, SNS may be a potential therapeutic mechanism of TNS.
4
Wang, Xiaoqiang, Karineh Petrossian, Miao-Juei Huang, Kohei Saeki, Noriko Kanaya, Gregory Chang, Somlo George, and Shiuan Chen. "AR Is Not an Independent Marker for TNBC: The Lesson We Learn From Two PDX Models." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A804—A805. http://dx.doi.org/10.1210/jendso/bvab048.1636.
Full textAbstract:
Abstract Extensive efforts, through cell line-based models, have been made to characterize the androgen receptor (AR) signaling pathway in triple-negative breast cancer (TNBC). However, these efforts have not yet reached a consensus with regards to the mechanism of AR in TNBC. On the other hand, patient-derived xenografts (PDXs) are generally considered more appropriate than cell line-based models for recapitulating the structural and molecular features of a patient’s tumor, but only a few have been reported to be AR-positive TNBC. In our study, we identified and molecularly characterized two new, AR-positive TNBC PDX models and assessed the impacts of AR agonist (DHT) and antagonist (enzalutamide) on tumor growth and gene expression profiles by utilizing immunohistochemistry (IHC), western blots, and RNA-Seq and TNBC subtyping analyses. Two PDX models, termed TN1 and TN2, were derived from two grade 3 TNBC tumors, each containing 1~5% of AR positive tumor cells. DHT activated AR in both PDX tumors by increasing AR nuclear localization and protein levels. However, the endpoint tumor volume of DHT-treated TN1 was 3-folds smaller than that of non-treated TN1 tumors. Conversely, the endpoint tumor volume of DHT-treated TN2 was 2-folds larger than that of non-treated TN2. Moreover, enzalutamide failed to antagonize DHT-induced tumor growth in TN2. The RNA-Seq analyses revealed that DHT suppressed gene expression in TN1 (961 down-regulated genes versus 149 up-regulated genes), while the DHT promoted gene expression in TN2 (673 up-regulated genes versus192 down-regulated genes). TNBC subtyping analyses based on RNA-Seq data predicted distinct molecular subtypes of TN1 and TN2: TN1 correlated to a basal-like 1 (BL1) subtype, and TN2 correlated to a basal-like 2 (BL2) subtype. These analyses suggest that TN1 and TN2, which both express functional AR, are two molecularly distinct PDX models that expand our current knowledge of AR-positive TNBC. Our results do not support that AR is a suitable therapeutic target in TNBC. To our best knowledge, the molecular mechanisms of AR in TNBC are equivocal and should be evaluated using clinically relevant models, considering both the heterogeneous expression of AR in TNBC and the general complexities of AR signaling.
5
Baber, Jessica R., Jason E. Sawyer, Ben P. Holland, Kendall J. Karr, Alyssa B. Word, and Tryon A. Wickersham. "Net protein contribution of beef feedlots from 2006 to 2017." Translational Animal Science 3, no. 4 (July 1, 2019): 1575–84. http://dx.doi.org/10.1093/tas/txz142.
Full textAbstract:
Abstract: Feedlot efficiency increases as technologies are adopted and new feed ingredients, especially byproducts, become available and incorporated into diets. Byproduct availability increased in response to the renewable fuels standard of 2005, creating substantial amounts of feedstuffs best used by ruminants. Cereal grains have been partially replaced with human-inedible byproducts, as they provide comparable levels of energy in cattle diets. To evaluate the effects of changes in diet and feedlot production practices on net protein contribution (NPC) and human-edible protein conversion efficiency (HePCE) across time, a deterministic NPC model was used. NPC was assessed for the feedlot industry using lot level production data from 2006 to 2017 for eight commercial feedlots. Ingredient and nutrient composition was collected for a representative starter and finisher diet fed for each year from each feedlot. NPC was calculated by multiplying human-edible protein (HeP) in beef produced per unit of HeP in feed by the protein quality ratio (PQR). Systems with NPC >1 positively contribute to meeting human protein requirements; NPC < 1 indicates competition with humans for HeP. NPC was regressed on year to evaluate temporal change in NPC. Feedlots were categorized as increasing NPC (INC; slope > 0) or constant NPC (CON; slope = 0) according to regression parameter estimates. Four feedlots were categorized as INC and four were CON. The rate of change in PQR was similar for CON and INC (P ≥ 0.79), although rates of change among INC and CON differed for byproduct and cereal grain inclusion (P ≤ 0.01) across years evaluated. Feedlots categorized as INC reduced HeP consumed by 2.39% per year, but CON feedlots did not reduce HeP consumed each year (0.28%). Cattle received and shipped by INC were lighter than those in CON feedlots (P < 0.01). Across years, INC produced more HeP (20.9 vs. 19.2 kg/hd) than CON (P < 0.01), and both feedlot types tended to improve HeP gained over time (0.1 kg per year; P = 0.10). Differences in slope over time for INC and CON were observed for conversion efficiency of HeP (P < 0.01). NPC increased 0.027 units per year for INC (P < 0.01) and was 0.94 in 2017. NPC by the feedlot sector improved from 2006 to 2017, decreasing the amount of human-edible feeds required to produce more high-quality protein from beef.
6
Knuutila, Sakari, Katja Merkkiniemi, Mikko Rönty, Aino Wirtanen, Satu Maria Remes, Stuart Bloor, Kaisa Salmenkivi, Aija Knuuttila, and Virinder Kaur Sarhadi. "Targeted deep sequencing as a diagnostic and research method for detecting EGFR and ALK pathway driver genes in FFPE tissue of lung and colorectal carcinomas." Journal of Clinical Oncology 30, no. 30_suppl (October 20, 2012): 39. http://dx.doi.org/10.1200/jco.2012.30.30_suppl.39.
Full textAbstract:
39 Background: Molecular targeted tyrosine kinase inhibitor (TKI) treatments have made it crucial to perform diagnostic tests of multiple molecular targets. In lung carcinoma there are close to ten clinically relevant gene mutations, copy number alterations and/or gene fusions, such as ALK, EGFR, ERBB2, KRAS, BRAF, MET, PTEN, PI3KCA, ROS1 and RET. Presently, several different tests are utilized, requiring a high amount of tumor material and long turnaround time. Next generation sequencing or targeted deep sequencing (TDS) has opened a new era for rapid genome-wide analyses of mutations, copy number alterations and gene fusions. Our aimwas to 1) prove feasibility for applying TDS to FFPE samples, 2) compare mutations detected by prevalent methods & TDS, and 3) mine novel clinically and biologically relevant genes in lung and colorectal carcinoma. Methods: For TDS, we selected 192 lung carcinoma and colorectal carcinoma related genes and microRNA genes, focusing on the EGFR and ALK pathways. In total, 98 FFPE specimens were studied. Agilent SureSelect system and Illumina sequencing was adopted for the analysis. For diagnostic validation the following genes were selected: EGFR, KRAS, BRAF, PTEN, PI3K, RET and ALK. TDS results were confirmed by PCR, FISH and IHC. Results: We focused on the genes selected for diagnostic validation. Successful results were obtained from all specimens. The results from TDS correlated significantly with those obtained from PCR, FISH, and IHC. Importantly, TDS revealed novel mutations not detected by targeted PCR. Conclusions: An enormous advantage of TDS is that multiple mutation screening can be achieved in one analysis (saving time and material), and most importantly, provides enormous amounts of novel information, for example understanding mechanisms for drug resistance. This study was supported by Finnish Academy, Sigrid Jusélius Foundation, Finnish Cancer Organizations, the special governmental subsidy research funds appropriated to the Helsinki and Uusimaa Hospital District (HUS EVO), Pfizer Oy, AstraZeneca AS, Lab21 Ltd, Abbott Molecular Inc.
7
Ramos Parrací, Carlos Alberto, Elvia Constanza Palomino Devia, and Nelson Rodríguez Arias. "Aptitud cardiorrespiratoria y adiposidad frente al nivel de actividad física." Educación Física y Ciencia 19, no. 1 (June 29, 2017): 020. http://dx.doi.org/10.24215/23142561e020.
Full textAbstract:
Con el objetivo de determinar el comportamiento de la Aptitud Cardiorrespiratoria y la adiposidad frente al nivel de actividad física de la población adulta de la ciudad de Neiva, se evaluaron 972 sujetos entre 18 a 75 años de edad. Estudio Descriptivo Correlacional. Los datos se analizaron en SPSS-23 e InfoStat/Profesional 1,2. La metodología partió de la descripción de variables, posteriormente el grado de asociación entre ellas (coeficiente de correlación de Pearson), los grupos conformados se compararon (Prueba ANOVA y comparación multiple LSD Fisher); por último, se estableció el grado de agrupamiento entre las variables (Prueba Average Linkage). Los resultados evidenciaron diferencias significativas en índice de masa corporal (IMC), Frecuencia Cardiaca Reposo (FCR) y Consumo Máximo de Oxigeno (VO2máx.), entre activos e inactivos; asociación del 5%, entre el IMC con FCR y VO2máx, índice cintura–cadera (ICC) y porcentaje grasa corporal (%GC); del ICC con %GC, VO2máx, Tensión Arterial Sistólica (TAS) y Diastólica (TAD); del %GC con FCR, TAD y VO2máx; la FCR con VO2máx; la TAS con TAD y VO2máx rechazando la hipótesis de independencia. Concluyendo que los indicadores de adiposidad y aptitud cardiorrespiratoria evidencian la combinación de factores de riesgo de enfermedades de índole hipocinético en la población.
8
Malik, Harbani, Ben Buelow, Udaya Rangaswamy, Aarti Balasubramani, Andrew Boudreau, Kevin Dang, Laura Davison, et al. "TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion." Blood 134, Supplement_1 (November 13, 2019): 4070. http://dx.doi.org/10.1182/blood-2019-123226.
Full textAbstract:
Introduction The restricted expression of CD19 in the B-cell lineage makes it an attractive target for the therapeutic treatment of B-cell malignancies. Many monoclonal antibodies and antibody drug conjugates targeting CD19 have been developed, including bispecific T-cell redirecting antibodies (T-BsAbs). In addition, anti-CD19 chimeric antigen receptor T-cells (CAR-T) have been approved to treat leukemia and lymphoma. However, despite the impressive depth of responses achieved by T-cell redirecting approaches such as T-BsAbs and CAR-T cells, toxicity from over-activation of T-cells remains a substantial limitation for this type of therapy, in particular neurotoxicity. In designing TNB-486, a novel CD19 x CD3 T-BsAb, we endeavored to retain activity against CD19-positive tumor cells while limiting the cytokine secretion thought to underlie toxicity from T-cell redirecting therapies. Utilizing TeneoSeek, a next generation sequencing (NGS)-based discovery pipeline that leverages in silico analysis of heavy chain only/fixed light chain antibody (HCA/Flic, respectively) sequences to enrich for antigen specific antibodies, we made a high affinity αCD19 HCA and a library of αCD3 Flic antibodies that showed a >2 log range of EC50s for T cell activation in vitro. Of note, the library contained a low-activating αCD3 that induced minimal cytokine secretion even at concentrations that mediated saturating T-cell dependent lysis of lymphoma cells (when paired with an αCD19 HCA). We characterized the relative efficacy and potential therapeutic window of this unique molecule, TNB-486, in vitro and in vivo and compared it to two strongly activating bispecific CD19 x CD3 antibodies similar to those currently available and in clinical development. Methods Affinity measurements of the αCD19 moiety were made via Biacore (protein) and flow cytometry (cell surface). Stability measurements were made by subjecting the molecule to thermal stress and the %aggregation was measured by Size Exclusion Chromatography. T-cell activation was measured via flow cytometry (CD69 and CD25 expression) and cytokine was measured by ELISA (IL-2, IL-6, IL-10, INF-ɣ, and TNFα) in vitro. Lysis of B-cell tumor cell lines (Raji, RI-1, and Nalm6) was measured via flow cytometry in vitro. In vivo, NOG mice were engrafted subcutaneously with NALM-6 or SUDHL-10 cells and intravenously with human peripheral blood mononuclear cells (huPBMC), and the mice treated with multiple doses of TNB-486 or negative or positive control antibody. Tumor burden was evaluated via caliper measurement. Pharmacodynamic/Pharmacokinetic (PK/PD) studies were performed in NOG mice. A pharmacokinetic (PK) study was performed in BALB/c mice, and a tolerability and PK study are ongoing in cynomolgus monkeys. Results TNB-486 bound to cell surface CD19 with single digit nanomolar affinity (~3nM). EC50s for cytotoxicity were in the single-digit nanomolar range for TNB-486, and sub-nanomolar for the strongly activating controls; TNB-486 maximum achievable lysis was identical to the positive controls. TNB-486 induced significantly less cytokine release for all cytokines tested compared to the positive controls even at doses saturating for tumor lysis. No off-target activation was observed in the absence of CD19 expressing target cells. In vivo, TNB-486 eradicated all CD19-positive tumors tested (NALM-6 and SUDHL10) at doses as little as 1µg administered every four days after tumors had reached ~200mm3. TNB-486 showed a PK profile consistent with other IgG molecules in mice (T1/2 ~6 days in mice). Conclusions TNB-486 induced comparable lysis of CD19-positive tumor cells as the strongly activating control bispecific antibodies while inducing significantly reduced cytokine secretion, even at doses saturating for tumor lysis in vitro. In vivo TNB-486 eradicated all tested CD19 positive tumor cell lines in established tumor models. No off-target binding was observed. In summary, TNB-486 shows promise as a lymphoma therapeutic differentiated from T-cell targeted therapies currently in the clinic and in clinical trials. Disclosures Malik: Teneobio, Inc.: Employment, Equity Ownership. Buelow:Teneobio, Inc.: Employment, Equity Ownership. Rangaswamy:Teneobio, Inc.: Employment, Equity Ownership. Balasubramani:Teneobio, Inc.: Employment, Equity Ownership. Boudreau:Teneobio, Inc.: Employment, Equity Ownership. Dang:Teneobio, Inc.: Employment, Equity Ownership. Davison:Teneobio, Inc.: Employment, Equity Ownership. Force Aldred:Teneobio, Inc.: Equity Ownership. Iyer:Teneobio, Inc.: Employment, Equity Ownership. Jorgensen:Teneobio, Inc.: Employment, Equity Ownership. Pham:Teneobio, Inc.: Employment, Equity Ownership. Prabhakar:Teneobio, Inc.: Employment, Equity Ownership. Schellenberger:Teneobio, Inc.: Employment, Equity Ownership. Ugamraj:Teneobio, Inc.: Employment, Equity Ownership. Trinklein:Teneobio, Inc.: Employment, Equity Ownership. Van Schooten:Teneobio, Inc.: Employment, Equity Ownership.
9
Peffault De Latour, Regis, Jaroslaw P. Maciejewski, Austin G. Kulasekararaj, Loree Larratt, Ronald S. Go, David Dingli, Amanda Wilson, Philippe Gustovic, and Aleksandr Kulagin. "Prognostic Value of Clone Size in Paroxysmal Nocturnal Hemoglobinuria (PNH) for Thrombotic Events in Untreated Patients in the International PNH Registry." Blood 132, Supplement 1 (November 29, 2018): 1038. http://dx.doi.org/10.1182/blood-2018-99-111324.
Full textAbstract:
Abstract Background/Objective: The association between paroxysmal nocturnal hemoglobinuria (PNH) granulocyte clone size at disease onset and outcomes in patients with PNH remains unclear. Most but not all reports examining the relationship have shown a positive correlation between clone size and thrombotic events [TEs] in patients with PNH, but without a clear temporal association showing the prognostic value of clone size on the risk of TEs. The ongoing International PNH Registry (NCT01374360) is the largest prospective, observational study of patients with PNH conducted to date. The objective of this analysis was to examine the relationship between PNH granulocyte clone size at disease onset and risk of thrombosis after disease onset while untreated with a complement inhibitor in patients enrolled in the Registry. Methods: The current analysis included patients enrolled in the Registry as of April 2018 who had known demographics, were untreated with complement inhibitor therapy at enrollment, and had ≥12 months of untreated follow-up after disease onset. Baseline was defined as disease onset (earliest of a reported PNH clone, date of PNH diagnosis, or reported PNH symptom), and patients were stratified into 5 cohorts based on clone size at baseline (using the earliest reported clone prior to enrollment): cohort 1, clone size: 0.01-1%; cohort 2, clone size: >1-5%; cohort 3, clone size: >5-10%; cohort 4, clone size: >10-50%; cohort 5, clone size: >50%. Event rates for TEs and all major adverse vascular events (MAVEs; including TEs) were calculated for the time period from baseline to last follow-up. Other outcomes of interest included LDH ratio (LDH/LDH upper limit of normal [ULN]), hemoglobin levels, platelet counts, absolute neutrophil counts, and absolute reticulocyte counts at last follow-up. Results: A total of 2489 patients were eligible for the analysis. The majority of patients in the overall study population were female (54.0% [1343/2489]) and white (79.2% [1967/2484]). Mean (standard deviation [SD]) age at PNH start ranged from 36.4 (16.53) in cohort 5 to 44.2 (20.70) in cohort 1. Median time from baseline to last follow-up was 3.7 years in cohort 1, 4.3 years in cohort 2, 4.7 years in cohort 3, 5.6 years in cohort 4, and 6.8 years in cohort 5. Results for the outcomes of interest are summarized in the Table. All cohorts showed a risk of MAVE and TE during follow-up. Although estimated rates of MAVE and TE were highest in the >50% clone size cohort, there was no difference in the rate of MAVE or TE during follow-up across the 4 cohorts with clone size <50% at disease onset. Mean LDH ratio (LDH/LDH ULN) at last follow-up showed a statistically significant difference by clone size at baseline among the cohorts, ranging from a mean (SD) of 1.1 (1.34) in the patients with clone size <1% and increasing to 5.1 (3.81) in the patients with clone size >50% (P<0.0001). No difference in hemoglobin level at last follow-up was observed in the smaller clone size cohorts, although mean hemoglobin level was lower in patients with clone size >50% (P<0.0001). Similar trends were seen in mean platelet and absolute neutrophil counts across the smaller clone size cohorts, while patients with clone size >50% showed higher values (P<0.0001). Mean absolute reticulocyte count at last follow-up was lowest in patients with clone size 0.01-1%, and were incrementally higher in each successive clone-size cohort (P<0.0001). Conclusions: In this study, all patients with a PNH clone at disease onset were at risk for TEs and other MAVEs. Patients in the highest baseline PNH clone size strata (clone size >50%) had an approximately 2-times higher risk of TEs than patients with smaller clone sizes; Patients with small clone sizes (0.01-1%) were older and showed a higher prevalence of BMD. There was no difference in the prognostic value of clone size at disease onset on the risk of TEs and other MAVEs in patients with small (0.01-1% and 1-5%) versus medium-sized (5-10% or 10-50%) clones. Table Table. Disclosures Peffault De Latour: Alexion Pharmaceuticals, Inc.: Consultancy, Honoraria, Research Funding; Novartis: Consultancy, Honoraria, Research Funding; Pfizer Inc.: Consultancy, Honoraria, Research Funding; Amgen Inc.: Research Funding. Maciejewski:Alexion Pharmaceuticals, Inc.: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Alexion Pharmaceuticals, Inc.: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Apellis Pharmaceuticals: Consultancy; Apellis Pharmaceuticals: Consultancy; Ra Pharmaceuticals, Inc: Consultancy; Ra Pharmaceuticals, Inc: Consultancy. Kulasekararaj:Alexion Pharmaceuticals, Inc.: Consultancy, Honoraria, Other: Travel Support . Larratt:Alexion Pharmaceuticals, Inc.: Honoraria, Research Funding. Dingli:Millennium Takeda: Research Funding; Alexion Pharmaceuticals, Inc.: Other: Participates in the International PNH Registry (for Mayo Clinic, Rochester) for Alexion Pharmaceuticals, Inc.; Millennium Takeda: Research Funding; Alexion Pharmaceuticals, Inc.: Other: Participates in the International PNH Registry (for Mayo Clinic, Rochester) for Alexion Pharmaceuticals, Inc.. Wilson:Alexion Pharmaceuticals, Inc.: Employment, Equity Ownership. Gustovic:Alexion Pharma GmbH: Employment, Equity Ownership. Kulagin:Alexion Pharmaceuticals, Inc.: Consultancy, Honoraria.
10
Janicak, Paul, Karen Heart, and Bridget McGugan. "166 Post Market Rate of Seizures During TMS Treatment with NeuroStar® System Appears to Be Lower than Previously Estimated." CNS Spectrums 25, no. 2 (April 2020): 306. http://dx.doi.org/10.1017/s1092852920000826.
Full textAbstract:
Abstract:Objective: NeuroStar® Advanced Therapy System is a transcranial magnetic stimulation (TMS) device with FDA-clearance for the treatment of Major Depressive Disorder (MDD) in adult patients who have failed to receive satisfactory improvement from prior antidepressant medication in the current episode. With TMS, magnetic pulses are transmitted into the brain. Though the exact mechanism of action is unknown, it is postulated that resulting neuronal depolarization and changes in brain functional activity may be associated with various physiologic changes that lead to relief of depression in the indicated population. The type of magnetic field generated with TMS is not intended to induce a seizure during therapeutic use, but unintentional seizures have been reported during TMS treatment.No seizures were reported with the use of the NeuroStar® system in clinical trials conducted prior to FDA clearance. The estimated risk of seizure in the NeuroStar® label is approximately 1 in 30,000 treatments or 1 in 1,000 patients. Since introduction of the NeuroStar® system into clinical practice, the rate at which seizures have been reported is even lower.Methods:We conducted a review of literature that named the NeuroStar® Advanced Therapy System as the device used for TMS treatment and reviewed all seizure events reported to Neuronetics, Inc., directly or through FDA MedWatch through June 30, 2019. Articles reporting seizures in subjects with epilepsy during TMS treatment were excluded.Results:Previous comprehensive reviews of seizures induced by treatment with any TMS device by Wasserman et al. (1998) and Rossi et al. (2009) revealed that the rate of seizures is low. Many subjects that developed seizures during TMS had either received stimulation at parameters beyond current recommendations or had been predisposed to develop seizures in some way. Some of the events reported as seizures may, in fact, have been non-epileptic events.Our literature review and analysis of seizures reported to Neuronetics, Inc. revealed that the rate of seizures during TMS treatment with the NeuroStar® appears to be lower than the rate that is published in the NeuroStar® Advanced Therapy prescribing information.Conclusions:Seizures that take place during TMS treatment with the NeuroStar® system are rare. The rate of seizures reported directly to Neuronetics, Inc. is lower than that included in the NeuroStar® prescribing information. Our literature review validated seizures during TMS treatment with the NeuroStar® system reported in published literature have described either non-epileptic events (syncope) or occurred with risk factors for seizure induction, such as other predisposing clinical factors or treatment parameters outside the guideline recommend “safe” ranges.Funding Acknowledgements:Neuronetics, Inc.
Dissertations / Theses on the topic "Inc TNS"
1
Shelton, Heath W., and Russell W. Brown. "INHIBITION OF TNF-ALPHA DECREASES MICROGLIA ACTIVATION IN RATS NEONATALLY TREATED WITH POLY I:C." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/166.
Full textAbstract:
Introduction: Current medical treatment for individuals diagnosed with schizophrenia (SCHZ) primarily relies on the inhibition of the dopamine D2 receptor that has been shown to be supersensitive in these patients. Treatment occurs through the use of antipsychotic medication which leads to a number of debilitating dose-dependent side effects, such as weight gain, agranulocytosis, and seizures. Patients diagnosed with SCHZ have also been shown to have increased inflammation in their central nervous system (CNS), particularly within specific brain regions such as the prefrontal cortex and hippocampus. This is in large part due to the interaction between a pro-inflammatory cytokine called tumor necrosis factor-alpha (TNFa) and microglia, which are resident CNS defense cells. TNFa is a cell-signaling protein, regulates a variety of immune cells, and is involved in the acute phase reaction of inflammation. Upon activation by TNFa secretion, microglial cells switch from being anti-inflammatory (M2) to pro-inflammatory (M1), thereby resulting in neuroinflammation as well as synaptic loss and neuronal death. In this project, we hypothesized oral administration through the diet of a novel TNFa modulator (PD2024) developed by P2D Biosciences, Inc. (Cincinnati, OH) would significantly reduce microglia activation in rats neonatally treated with Polyinosinic:polycytidylic acid (poly I:C). Methods and Results: To test our hypothesis, four groups (Neonatal Poly I:C/TNFa, Neonatal Poly I:C/Control, Neonatal Saline/TNFa, and Neonatal Saline/Control) were intraperitoneally injected with either poly I:C or saline during postnatal days (P)5-7. Poly I:C is an immunostimulant that mimics neonatal infection in humans, which also has been found to be a factor for the development of SCHZ later in life. Between days (P)30-(P)60, the Neonatal Poly I:C/TNFa and Neonatal Saline/TNFa groups were orally administered PD2024 through the diet. After (P)60, brain tissue was evaluated by immunohistochemistry (IHC) and confocal microscopy. Immunohistochemistry was used to label microglial cells in the prefrontal cortex and hippocampus with a green fluorescent dye attached to Iba1, a protein that specifically binds to these cells. Upon completion of IHC, tissue was evaluated using a confocal microscope and then analyzed with NIH ImageJ software. Analysis parameters included cell count, sampled cell body fluorescence, and overall image fluorescence. The results obtained showed a significant decrease in microglia activation for the Poly I:C/TNFa group when compared to the Poly I:C/Control group, as well as similarities in activation levels with the Saline/Control group. These results were demonstrated in both sampled cell body fluorescence and overall image fluorescence measurements. Conclusion: This data supports the hypothesis that PD2024 is successful in reducing microglia activation through the modulation of TNFa. Therefore, treatment with a TNFa modulator such as PD2024 alongside of current antipsychotic medication could mediate neuroinflammation and reduce the dose-dependent side effects. This approach could be a promising therapeutic treatment option for those diagnosed with schizophrenia, as well as potentially for other neurocognitive and behavioral disorders.
2
Paschalinou, Eleni. "Nachweis von Punktmutationen im TNF-alpha- und INF-gamma-Promotor bei Patienten nach allogener Stammzelltransplantation oder Knochenmarktransplantation." [S.l. : s.n.], 2008.
Find full text
3
Romanatto, Talita. "Ação do fator de necrose tumoral alfa (TNF-'alfa') no hipotalamo : efeitos sobre expressão proteica, ingestão alimentar e consumo de 'O IND.2'/produção de 'CO IND.2'." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310369.
Full textAbstract:
Orientador: Licio Augusto VellosoDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-07T13:49:02Z (GMT). No. of bitstreams: 1 Romanatto_Talita_M.pdf: 698647 bytes, checksum: 63eca0e91717781c0ea52f0ebec9855e (MD5) Previous issue date: 2006
Resumo: A insulina e a leptina induzem uma potente resposta anorexigênica e termogênica atuando sobre neurônios do hipotálamo. Evidências recentes sugerem que a resistência à ação desses hormônios deve participar dos mecanismos centrais que favorecem o desenvolvimento da obesidade e sua associação com o diabetes mellitus. O consumo de dieta rica em gordura induz a expressão de proteínas pró-inflamatórias em hipotálamo de ratos, inclusive da citocina TNF-a. O presente estudo avaliou o efeito de diferentes doses intracerebroventriculares (ICV) de TNF-a sobre a ativação da via de sinalização da insulina, a ingestão alimentar e o consumo de O2/produção de CO2. Ratos Wistar, machos de oito semanas, foram canulados por via ICV e tratados com diferentes doses de TNF-a, insulina ou salina. A dose mais alta de TNF-a promoveu uma redução de 20% na ingestão alimentar de 12 horas, sendo esta redução inferior àquela produzida pela insulina. Na mesma dose, a citocina promoveu um aumento da temperatura corporal e do quociente respiratório. O TNF-a induziu a ativação de elementos da via pró-inflamatória no hipotálamo, como JNK, p38 e NF?B, o que resultou na transcrição de genes de resposta rápida e indução de proteínas da família SOCS. Com relação à via molecular da insulina, o TNF-a não induziu a ativação de substratos proximais e intermediários, no entanto, mesmo a dose mais baixa foi capaz de ativar elementos distais da via, como ERK e FOXO-1. Cocluindo, o TNF-a exerce um potente efeito anorexigênico e pró-termogênico no hipotálamo de ratos através de mecanismos independentes da ativação de proteínas proximais da via de sinalização da insulina. ERK e FOXO-1, que participam como intermediários em várias outras vias de sinalização, incluindo a via da insulina, são ativados pelo TNF-a no hipotálamo e podem estar envolvidas no efeito anorexigênico e pró-termogênico do TNF-a nesse órgão
Abstrasct: Insulin and leptin induce potent anorexigenic and pro-thermogenic responses in specialized neurons of the hypothalamus. Recent evidence suggest that resistance to the action of these hormones play a role in the mechanisms that favor the development of obesity and its common association with type 2 diabetes mellitus. The consumption of a fat-rich diet induces molecular and functional resistance to leptin and insulin in the hypothalamus, which is accompanied by the expression of pro-inflammatory proteins including the cytokine TNF-a. The present study has evaluated the effect of different doses of intracerebroventricular (ICV) TNF-a upon the activation of insulin signal transduction, food ingestion, and the consumption of O2/ production of CO2. For that, eight weeks old male Wistar rats were ICV cannulated and treated with saline, insulin or TNF-a. High dose TNF-a ?promotes a reduction of 20 % of 12 h food intake, which is an inhibitory effect marginally inferior than the one produced by insulin. In addition, TNF-a increases body temperature and respiratory quotient, effects not reproduced by insulin. TNF-a is also capable of activating canonical pro-inflammatory signal in the hypothalamus, inducing JNK, p38, and NF?B, which results in the transcription of early responsive genes and induction of proteins of the SOCS family. Finally, TNF-a does not activate signal transduction through early and intermediary elements of the insulin signaling pathway such as IRS-2 and Akt, however, TNF-a, even at low doses, is capable of activating late elements of the insulin signaling pathway such as ERK and FOXO-1. In conclusion, TNF-a exerts potent anorexigenic and pro-thermogenic effects in the hypothalamus through mechanisms independent of the activation of proteins that participate in early and intermediary steps of the insulin signaling pathway. ERK and FOXO-1, which act as late signal transducers for several signaling pathways, including insulin, are activated by TNF-a in the hypothalamus and may participate in the anorexigenic/pro-thermogenic effects of TNF-a in this organ
Mestrado
Medicina Experimental
Mestre em Fisiopatologia Médica
4
MARTINS, Norielem de Jesus. "Educa??o escolar ind?gena Guarani no Estado do Rio de Janeiro: tens?es e desafios na conquista de direitos." Universidade Federal Rural do Rio de Janeiro, 2016. https://tede.ufrrj.br/jspui/handle/jspui/1422.
Full textAbstract:
Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-02-13T18:54:40Z
No. of bitstreams: 1
2016 - NORIELEM DE JESUS MARTINS.pdf: 2936847 bytes, checksum: 3ed61dee02a4a0ddc4a4a8c6ab18a96f (MD5)Made available in DSpace on 2017-02-13T18:54:40Z (GMT). No. of bitstreams: 1 2016 - NORIELEM DE JESUS MARTINS.pdf: 2936847 bytes, checksum: 3ed61dee02a4a0ddc4a4a8c6ab18a96f (MD5) Previous issue date: 2016-06-10
La comprensi?n de la educaci?n como una pr?ctica cultural que se impone a los pueblos ind?genas, podemos reflexionar sobre nuestra ignorancia o negligencia de formas de educar a estas personas, lo que implica propias proceso de la civilizaci?n, los idiomas, las diversas concepciones del territorio y pertenencia. Las pol?ticas p?blicas para la educaci?n ind?gena en Brasil son recientes, y aunque se han conseguido muchos derechos en la educaci?n en los ?ltimos decenios, algunos no actualizan completamente. A pesar de la especificidad de los principios, la diferencia, la interculturalidad y el biling?ismo que apoyan la educaci?n ind?gena tambi?n identific? una fuerte influencia colonial en las pol?ticas p?blicas de Educaci?n Nacional, el di?logo y dificulta la implementaci?n de los derechos ind?genas. A pesar de estos callejones sin salida, las nuevas pol?ticas han ido constituyendo en una perspectiva intercultural, respetando la territorialidad ind?gena. En el estado de R?o de Janeiro, esta pol?tica comienza a tomar forma a partir de la acci?n de colaboraci?n entre el Estado, los municipios y el gobierno federal. Por lo tanto, el objetivo de esta investigaci?n es analizar la situaci?n de las pol?ticas p?blicas actuales de la educaci?n ind?gena guaran? en el Estado de R?o de Janeiro, la identificaci?n de las posibles formas de garantizar el derecho a la educaci?n con miras a la acci?n colaborativa. Para su realizaci?n, nos centramos en el enfoque cualitativo, observaci?n participante y las entrevistas realizadas en el periodo 2014-2015. Nuestro campo de estudio son las pol?ticas p?blicas para la educaci?n ind?gena en R?o de Janeiro llevadas a cabo por el Gobierno del Estado, los municipios donde est?n ubicados los pueblos guaran?es y universidades p?blicas. El an?lisis de los acuerdos de cooperaci?n entre las entidades federales de la pol?tica de los territorios Etnoeducacionais, nos dimos cuenta de la necesidad de invertir en un plan de acci?n que responda a las particularidades de cada pueblo y que permite una mayor autonom?a que el actual modelo de gesti?n, lo que permite la ejecuci?n de las garant?as los derechos alcanzados.
Compreendendo a educa??o escolar como uma pr?tica cultural que se imp?s aos povos ind?genas, podemos refletir sobre o nosso desconhecimento ou neglig?ncia sobre as formas de educar destes povos, que envolvem processos civilizat?rios pr?prios, linguagens, concep??es diversificadas de territ?rio e pertencimento. As pol?ticas p?blicas de Educa??o Escolar Ind?gena no Brasil s?o recentes, e embora muitos direitos tenham sido conquistados no campo educacional, ao longo das ?ltimas d?cadas, alguns n?o se efetivam plenamente. Apesar dos princ?pios da especificidade, diferen?a, interculturalidade e bilinguismo que fundamentam a Educa??o Escolar Ind?gena, identificamos, ainda, uma forte influ?ncia colonial nas pol?ticas p?blicas da Educa??o Nacional, dificultando o di?logo e a implementa??o de direitos ind?genas. Apesar destes impasses, novas pol?ticas v?m se constituindo em uma perspectiva intercultural, respeitando as territorialidades ind?genas. No Estado do Rio de Janeiro, esta pol?tica come?a a se estruturar a partir da a??o colaborativa entre Estado, Munic?pios e Governo Federal. Sendo assim, o objetivo desta pesquisa ? analisar a situa??o das atuais pol?ticas p?blicas de educa??o escolar ind?gena Guarani no Estado do Rio de Janeiro, identificando caminhos poss?veis para a garantia do direito ? educa??o, na perspectiva da a??o colaborativa. Para sua realiza??o, privilegiamos a abordagem qualitativa, a observa??o participante e entrevistas efetuadas no per?odo de 2014-2015. Nosso campo de estudo s?o as pol?ticas p?blicas para a Educa??o Escolar Ind?gena no Rio de Janeiro, realizadas pelo Governo Estadual, Munic?pios onde est?o localizadas as aldeias Guarani e Universidades P?blicas. Analisando o regime colabora??o entre entes federados a partir da pol?tica dos Territ?rios Etnoeducacionais, percebemos que ? necess?rio investir em um plano de a??o que contemple as especificidades de cada aldeia e que possibilite maior autonomia que a do modelo de gest?o atual, possibilitando a garantia de efetiva??o dos direitos conquistados.
5
Shelton, Heath W., W. Drew Gill, Prasad Gabbita, and Russell W. Brown. "The Effect of Two Novel Anti-Inflammatory Drugs on Sensorimotor Gating and Microglial Activation in the Poly I:C Rodent Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/160.
Full textAbstract:
Antipsychotic medications remain the first line of treatment for individuals diagnosed with schizophrenia (SCZ). However, antipsychotic treatment is often not compliant due to dysregulation of both the central (CNS) and autonomic (ANS) nervous systems, resulting in debilitating dose-dependent side effects. Recent work suggests a new approach for treatment of SCZ that could potentially lower treatment doses and reduce side effects. Increased neuroinflammation has been shown in patients diagnosed with SCZ, particularly within the prefrontal cortex (PFC) and hippocampal (HPC) regions of the brain. Tumor necrosis factor-alpha (TNFa) is one of the key pro-inflammatory cytokines observed to be secreted during the inflammatory response. When TNFa is chronically secreted, resident CNS microglia become pro-inflammatory and toxic to the local environment. Microglial activation alongside of dopamine dysregulation thereby results in both the behavioral and neuroinflammatory aspects of SCZ. In this study, we hypothesized dietary administration of two different novel TNFamodulators (PD2024 – Experiment 1 and PD340 – Experiment 2) developed by our collaborators from P2D Bioscience, Inc. (Cincinnati, OH) would alleviate auditory sensorimotor gating deficits and reduce microglial cell activation caused by neonatal polyinosinic:polycytidylic acid (Poly I:C) treatment in rats, which is a validated rodent model of SCZ. Four groups (Experiment 1: Poly IC/PD2024, Poly IC/Control, Saline/PD2024, Saline/Control and Experiment 2: Poly IC/PD340, Poly IC/Control, Saline/PD340, Saline/Control) were intraperitoneally administered either Poly I:C (2 mg/kg) or saline (0.9% NaCl) from postnatal days 5-7. From P30-67, animals were placed on the experimental diet containing either low (10 mg/kg) or high (30 mg/kg) doses of either PD2024 or PD340, whereas the control animals remained on a normal diet. Prepulse inhibition (PPI) was used to test for auditory sensorimotor gating (behavioral abnormalities) in both adolescence (P44-46) and in adulthood (P60-66). At P67, immunohistochemistry (IHC) and confocal microscopy were used to evaluate and examine microglial cell activation using the Iba1-GFP antibody (neuroinflammatory abnormalities) in the PFC and HPC. Results revealed auditory sensorimotor gating deficits in Poly IC/Controls were alleviated in both adolescence and adulthood with either PD2024 or PD340. It was also found that both TNFa modulators significantly reduced microglial activation in the HPC, but not the PFC. The data supports our hypothesis that dietary administration of PD2024 or PD340 alleviates behavioral deficits and decreases neuroinflammation generated from the Poly I:C rodent model of SCZ. Therefore, an approach with a TNFa modulator alongside of current antipsychotic medications could treat both the behavioral and neuroinflammatory aspects of SCZ.
6
Spratte, Julia [Verfasser]. "Heparine modulieren humane endometriale Stromazellen im Hinblick auf deren Differenzierung und Reaktionsverhalten gegenüber TNF-α und INF-γ / Julia Hehui Spratte." Greifswald : Universitätsbibliothek Greifswald, 2013. http://d-nb.info/1033246271/34.
Full text
7
Roehe, Nara Simone. "A ind?stria automobil?stica e a pol?tica econ?mica do governo Geisel: tens?o em uma parceria hist?rica (1974 - 1978)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2011. http://tede2.pucrs.br/tede2/handle/tede/2393.
Full textAbstract:
Made available in DSpace on 2015-04-14T13:47:30Z (GMT). No. of bitstreams: 1
431090.pdf: 1270992 bytes, checksum: 3bec9656fd7e1d8f1511f6eefee31164 (MD5)
Previous issue date: 2011-03-31O estabelecimento da ind?stria automobil?stica multinacional deu-se na d?cada de 1950, n?o somente atrav?s do esfor?o, mas tamb?m da disposi??o e da estrat?gia do Estado brasileiro. Seguindo o modelo desenvolvimentista, a cria??o do GEIA, em 1956, destacou-se como sendo a primeira legisla??o espec?fica para o setor automotivo que estabeleceu as regras, assim como a concess?o de est?mulos e desest?mulos para a instala??o e atua??o daquela ind?stria no pa?s. No entanto, com as implica??es pol?ticas posteriormente ocorridas, o GEIA foi desmembrado e sua atua??o, como instrumento legal, levada ? inexpressividade. Por outro lado, ap?s sua matura??o no pa?s hospedeiro, entre os anos de 1968 e 1973, a ind?stria automobil?stica se apresentou como um dos segmentos l?deres e principais pilares da expans?o econ?mica brasileira, contribuindo de forma significativa para o crescimento do PIB nacional, cuja varia??o percentual no per?odo consagrou o milagre econ?mico. Mas, frente ? exaust?o do crescimento interno acelerado e ? crise internacional do petr?leo, a partir de 1974, o governo Geisel adotou medidas restritivas preconizando a busca do saneamento econ?mico. Estas diretrizes do Estado, ao serem aplicadas, promoveram diverg?ncias entre os interesses corporativos daquele setor da ind?stria e os interesses nacionais do Brasil. Nesse sentido, depois de um momento de grande expans?o e desregulamenta??o, o ajustamento da ind?stria automobil?stica as novas pol?ticas econ?micas conflitaram o governo com aquele segmento que ? considerado o motor da industrializa??o brasileira
8
Paim, Francine Chimelo. "Citocinas pró-inflamatórias em ratos experimentalmente infectados por Trypanosoma evansi." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/10087.
Full textAbstract:
Conselho Nacional de Desenvolvimento Científico e TecnológicoThe aim of this study was to measure the levels of interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin 1 (IL-1) and interleukin 6 (IL-6) in serum of rats experimentally infected with Trypanosoma evansi and to correlate with the hematological parameters. Seventy-six rats (Wistar) were divided into two groups. Group C (control) composed of twenty-eight non-inoculated rats distributed in four subgroups with seven animals each (C3, C5, C10 and C20), which received 0.2 mL saline by intraperitoneally. The group T (infected) formed of forty-eight rats was inoculated intraperitoneally with cryopreserved blood containing 1x106 trypomastigotes per animal. These, eight animals died between 5th -7th days post-infection. The remaining animals were divided into four subgroups with ten animals (T3, T5, T10 and T20) according to parasitemia degree. The blood samples were collected by cardiac puncture at the day 3 (C3, T3), 5 (C5, T5), 10 (C10, T10) and 20 (C20, T20) post infection (pi) to perform the complete blood count and determination of IFN-γ, TNF-α, IL-1 and IL-6 levels using an ELISA quantitative sandwich. Immediately after collection the animals were euthanized. The levels of all measured cytokines increased significantly (P < 0.01) in infected animals compared to the controls. T. evansi infection in rats caused an increase in serum IFN-γ, TNF-α, IL-1 and IL-6 and this increase was observed during the whole experimental infection. In addition, the increase in the cytokine levels was concomitant and directly correlated with parasitemia and anemia development at the parasitemia peak. These results suggest a synergism between these cytokines contributing to the development of anemia and the regulation of the immune response against the parasite.
O objetivo deste estudo foi avaliar os níveis séricos das citocinas pró-inflamatórias interferon-gama (INF-γ), fator de necrose tumoral-alfa (TNF-α), interleucina 1 (IL-1) e interleucina 6 (IL-6) em ratos experimentalmente infectados por Trypanosoma evansi e estabelecer uma correlação com os parâmetros hematológicos. Setenta e seis ratos (Wistar) machos foram divididos em dois grupos experimentais. O Grupo C (controle) foi composto por vinte e oito ratos não inoculados distribuídos em quatro subgrupos com sete animais cada (C3, C5, C10 e C20), que receberam 0,2 mL de solução fisiológica pela via intraperitoneal. O grupo T (infectados) formado por quarenta e oito ratos inoculados intraperitonealmente com sangue criopreservado, contendo 1x106 tripomastigotas de T. evansi por animal. Destes, oito morreram entre o 5º e 7º dia pós-infecção. Os animais restantes foram divididos em quatro subgrupos de dez animais cada (T3, T5, T10 e T20) de acordo com o grau de parasitemia. As amostras de sangue foram coletadas por punção cardíaca, nos dias 3 (C3, T3), 5 (C5, T5), 10 (C10, T10) e 20 (C20,T20) pós-infecção (pi) para a realização do hemograma e determinação dos níveis séricos de INF-γ, TNF-α, IL-1 e IL-6 pela técnica de ELISA tipo sanduíche. Imediatamente após as coletas os animais eram submetidos à eutanásia. Os níveis de citocinas pró-inflamatórias aumentaram significativamente (P<0,01) nos animais infectados em relação ao grupo controle. A infecção por T. evansi em ratos provocou um aumento nos níveis séricos de INF-γ, TNF-α, IL-1, IL-6 e esse aumento foi observado durante toda a infecção experimental. Além disso, o aumento nos níveis de citocinas foi diretamente correlacionado com a parasitemia e o desenvolvimento da anemia. Estes resultados sugerem um sinergismo entre essas citocinas contribuindo para o desenvolvimento da anemia e regulação da resposta imune contra o parasito.
9
Hisada, Toru. "Indigenous Development and Self-Determination in West Papua: A Case Study of the Socio-Political and Economic Impacts of Mining upon the Amungme and Kamoro Communities of West Papua." The University of Waikato, 2007. http://hdl.handle.net/10289/2457.
Full textAbstract:
Since West Papua was colonized by Indonesia in 1963, West Papuans have endured one of the most disastrous experiences of cultural and environmental destruction, human rights abuses and mass killing of the twentieth century. In the Western Highlands of West Papua, where Freeport McMoRan, a mining company from Louisiana, United States (U.S.), operates, there have been long-standing disputes over environmental justice, human rights, the right to control development, and wealth distribution. Substantial research has been done on the negative impacts of the Freeport's operation on the Amungme and Kamoro communities who reside in the company's operating area. Yet, limited research has been done regarding Freeport's social policies and the possible solutions to the issues which are crucial for the further development of Amungme and Kamoro. Therefore, the thesis firstly examines Freeport's recent social policies which have attempted to address the two communities' concerns as well as the social problems the company has caused around its operating area. The examination suggests that genuine reconciliation between Amungme and Kamoro communities and Freeport is a crucial next step in achieving successful community development in the area. The thesis employs a case study of the South African reconciliation processes via Truth and Reconciliation Commission (TRC) to explore the prospects of achieving successful community development in Freeport's operating area of West Papua which might lead to prosperity for the Amungme and Kamoro peoples. In addition to this, the prospect of preventing the human rights violations by the Indonesian Military (Tentera Nasional Indonesia-TNI) is considered. The TNI, by carrying out the role of protecting the Freeport operation, has until today committed a large number of human rights violations against indigenous West Papuans around the mine thus preventing and inhibiting the future development of Amungme and Kamoro communities. Since major countries, including the U.S., the United Kingdom (UK), New Zealand and Australia, have until today, supported the Indonesia state and the TNI, the attitude of Pacific Island states towards the issue is examined. Finally, although the above processes are important, the study suggests the more important role of the Amungme and Kamoro themselves in taking responsibility for their plight and taking positive actions wherever possible to solve the issues surrounding them. Although the conflict continues to the present day, the research contained in the thesis outlines the situation in West Papua only up until November 2006.
10
Castilho, Pereira Ione Aparecida Martins. "Em tudo semelhante, em nada parecido : uma an?lise comparativa dos planos urbanos das miss?es jesu?ticas de Mojos Chiquitos, Guarani e Maynas (1607-1767)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2014. http://tede2.pucrs.br/tede2/handle/tede/2485.
Full textAbstract:
Made available in DSpace on 2015-04-14T13:48:07Z (GMT). No. of bitstreams: 1
455137.pdf: 4842181 bytes, checksum: 8686c0e0cd7cdf1d0f7dcb205003de7f (MD5)
Previous issue date: 2014-02-25This thesis intends to present a comparative analysis of the spatial organization of the urban plans of the jesuitic missions Guarani, Chiquitos, Mojos and Maynas. This study aims to know to what extent the evangelizer project undertook by Society of Jesus was similar and different concerning the spatial organization of these four missionary spatialities. To answer this inquiry, we established the years of 1607 to 1767 as a temporal delimitation. Such dates refer to the beginning of the jesuitic action in the Guarani missions, passing through Maynas missions foundation (1636), Mojos (1682), Chiquitos (1690), and finally the expulsion of the jesuits from Spanish America (1767). About the sources which are the focus of our analysis and comparison, they are both documental and bibliographic. Thus, what we seek is advance beyond the brief comparisons and the juxtapositions of informations in blocks of synthesis. Therefore, we intend to demonstrate, through a comparative analysis, that the diverse forms of existing, produced by indigenes and jesuits in these missionary spatialities, created not only differences, but also similarities from this relation with the inhabited space.
A presente tese tem por finalidade apresentar uma an?lise comparativa dos planos urbanos das miss?es jesu?ticas Guarani, Chiquitos, Mojos e Maynas. O objetivo deste estudo ? saber em que medida o projeto evangelizador empreendido pela Companhia de Jesus foi semelhante e diferente na organiza??o espacial destas quatro espacialidades missioneiras. Para responder a este questionamento, estabelecemos como delimita??o temporal os anos de 1607 a 1767. Tais datas referem-se ao in?cio da a??o jesu?tica nas miss?es Guarani, passando pelas funda??es das miss?es de Maynas (1636), Mojos (1682) e Chiquitos (1690), e, por fim, a data de expuls?o dos jesu?tas da Am?rica Espanhola (1767). J? as fontes que constituem o foco de nossa an?lise e compara??o s?o tanto documentais quanto bibliogr?ficas. Sendo assim, queremos ? avan?ar para al?m das breves compara??es e das justaposi??es de informa??es em blocos de s?nteses. Pretendemos demonstrar ent?o, atrav?s de uma an?lise comparativa, que as diversas formas do existir, produzidas por ind?genas e jesu?tas nestas espacialidades missioneiras, criaram como resultado desta rela??o com o espa?o habitado tanto diferen?as quanto semelhan?as.
Books on the topic "Inc TNS"
1
1953-, Large Jeanne, ed. Tis the season. Woodinville, WA: Martingale & Company, 2010.
Find full text
3
T.S. Eliot, Vedanta, and Buddhism. Vancouver: University of British Columbia, 1985.
Find full text
4
Ricks, Christopher B. T.S. Eliot and prejudice. Berkeley: University of California Press, 1988.
Find full text
9
Chatterjee, Sati. T.S. Eliot: Encounters with reality. Calcutta, India: Papyrus, 1990.
Find full text
10
Chatterjee, Sati. T.S. Eliot: Encounters with reality. Calcutta, India: Papyrus, 1990.
Find full textBook chapters on the topic "Inc TNS"
1
Melsheimer, Frank. "DFM Engineering, Inc. Generation III Telescope Control System TCS 68000." In Instrumentation for Ground-Based Optical Astronomy, 732–41. New York, NY: Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3880-5_78.
Full text
2
Watanabe, Akira. "TNS → AGR-S → COMP." In Studies in Natural Language and Linguistic Theory, 24–63. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-015-8615-3_2.
Full text
3
Watanabe, Akira. "V → AGR-O → TNS/ASP." In Studies in Natural Language and Linguistic Theory, 64–169. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-015-8615-3_3.
Full text
4
Schattenberg, Jörn M., and Mark J. Czaja. "TNF/TNF Receptors." In Signaling Pathways in Liver Diseases, 161–77. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00150-5_10.
Full text
5
Nielson, Seth James, and Christopher K. Monson. "TLS Communications." In Practical Cryptography in Python, 293–359. Berkeley, CA: Apress, 2019. http://dx.doi.org/10.1007/978-1-4842-4900-0_8.
Full text
6
Mann, Amrit, Mark J. Czaja, and Jörn M. Schattenberg. "TNF signaling." In Signaling Pathways in Liver Diseases, 186–202. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118663387.ch14.
Full text
7
Klopfer, Eric, Hal Scheintaub, Wendy Huang, and Daniel Wendel. "StarLogo TNG." In Artificial Life Models in Software, 151–82. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-285-6_6.
Full text
8
Quirchmayr, Gerald, and Reinhold Schimak. "TIS/MM." In Information and Communications Technologies in Tourism, 80–86. Vienna: Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9343-3_13.
Full text
9
Vardanyan, Marina, Edward C. Parkin, and Horacio L. Rodriguez Rilo. "Infliximab/Anti-TNF." In Immunotherapy in Transplantation, 385–98. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444355628.ch26.
Full text
10
David, Jean-Pierre, and Georg Schett. "TNF and Bone." In Current Directions in Autoimmunity, 135–44. Basel: KARGER, 2010. http://dx.doi.org/10.1159/000289202.
Full textConference papers on the topic "Inc TNS"
1
Lins, Lucas Costa, Iana Carneiro Pinto, Nathalia Lima Schramm dos Santos, Vitor de Oliveira Silva, and Marcos Lázaro da Silva Guerreiro. "INFLUÊNCIA DA QUIMIOTERAPIA NA RESPOSTA IMUNOLÓGICA CELULAR EM CAMUNDONGOS INFECTADOS COM AS CEPAS Y E COLOMBIANA DO TRYPANOSOMA CRUZI." In I Congresso Brasileiro de Parasitologia Humana On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/741.
Full textAbstract:
Introdução: Estudos sugerem que o tratamento quimioterápico estimula o sistema imunológico em camundongos infectados com cepas do T. cruzi. Objetivo: avaliar a influência do tratamento com Benzonidazol sobre a resposta imunológica celular em camundongos infectados com a cepa Y (suscetível) e Colombiana (resistente). Material e métodos: 150 camundongos, subdivididos em: Infectados tratados cepa Y (YT) e não tratados (Y-NT); Colombiana tratados (COL-T) e não tratados (COL-NT), Tratados não infectados (TNI) e Controles sem tratamento (CI). O inóculo foi 1,0 x 104 por via intraperitoneal. Os procedimentos estiveram de acordo ao protocolo CEUA, 013/09. O tratamento foi iniciado no pico parasitêmico das cepas, sendo no 7º dia após a infecção nos infectados pela cepa Y e, nos tratados e não infectados, no 18º nos infectados pela cepa Colombiana. A quimioterapia foi em 60 doses (100mg/kg/dia). Os camundongos eutanasiados na fase aguda e crônica nos grupos tiveram a resposta celular investigada pelas citocinas IL-6 IL-10, MCP-1, INF-γ e TNF-α e pelas subpopulações celulares no baço de CD4+ , CD8+ , células de memórias CD62L, células B e macrófagos. Resultados: as citocinas circulantes IL-6 IL-10, MCP-1, INF-γ e TNF-α, foram mais elevadas nos animais infectados com a cepa Y, o tratamento com Benz, não alterou os índices circulantes nos TNI. A citometria na fase aguda demonstrou maior frequência de CD4+ e CD8+ no grupo TNI; de células de memória (CD62L/CD4 e CD8) no grupo YT; de CD11b no grupo COL-NT fase aguda e na YT na fase crônica; e de células B (B220) no grupo CI. Na fase crônica maior frequência de CD4+ e CD8+ no grupo COL-T; de células de memória: (CD4/CD62L) no grupo YT e (CD8/CD62L) no COL-T; de CD11b no YT; e de células B (B220) CI. Conclusão: Nossos resultados sugerem que o tratamento com Benz tem influência na resposta imunológica celular em camundongos.
2
Ovchinnikov, M. Yu, A. A. Ilyin, N. V. Kupriynova, V. I. Penkov, and A. S. Selivanov. "Attitude dynamics of the first Russian nanosatellite TNS-0." In 57th International Astronautical Congress. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2006. http://dx.doi.org/10.2514/6.iac-06-c1.1.06.
Full text
3
"Session TNS: Telecommunication networks and services." In TELSIKS 2011 - 2011 10th International Conference on Telecommunication in Modern Satellite, Cable and Broadcasting Services. IEEE, 2011. http://dx.doi.org/10.1109/telsks.2011.6112079.
Full text
4
Goel, Raghav, Neha Shah, Rachana Visaria, Giulio F. Paciotti, and John C. Bischof. "Biodistribution of TNF-alpha Coated Gold Nanoparticles in an In Vivo Cancer Model." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192931.
Full textAbstract:
Over the past several years, there has been an increasing interest in the use of nanoparticles as a tool for treatment of cancer. We have shown tremendous augmentation and control (without toxicity) of both heat and cold-based thermal therapy for cancer treatment with a gold based nanodrug-CYT-6091 (Cytimmune Sciences, Inc.) [1–3]. To reach the full potential of these nanodrugs for both stand-alone solid cancer treatment and as adjuvant to thermal therapy, there is a need to understand the in vivo biodistribution and their short-term and long-term tissue interaction.
5
Richter, Ron. "2003 Upgrades at the GVRD Waste-to-Energy Facility." In 12th Annual North American Waste-to-Energy Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/nawtec12-2203.
Full textAbstract:
Montenay Inc. has operated the Greater Vancouver Regional District’s (GVRD) Waste-to-Energy Facility since it began commercial operation in 1988. The facility has a throughput of 720 tonnes (800 tons) per day in three lines. It utilizes Martin grate technology and dry lime injection with a reverse pulse jet fabric filter. The original facility design did not include a steam turbogenerator for energy recovery. The facility produced process steam at near saturation temperature to supply a recycle paper mill. The aging mill has reduced the fraction of steam used in recent years. This caused the GVRD and Montenay Inc. to cooperate in a major facility upgrade that began in 2001 and was completed in August of 2003. The complete project includes a turbogenerator, major boiler improvements and modernization of the boiler controls, while continuing to service the recycle paper mill.
6
"Magnetic Attitude Control System for the Russian Nano-Satellite TNS-1." In 55th International Astronautical Congress of the International Astronautical Federation, the International Academy of Astronautics, and the International Institute of Space Law. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2004. http://dx.doi.org/10.2514/6.iac-04-a.3.10.
Full text
7
O'Neill, Mark, Scott Ruoti, Kent Seamons, and Daniel Zappala. "TLS Proxies." In IMC 2016: Internet Measurement Conference. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2987443.2987488.
Full text
8
null. "The Birmingham TCS Centre." In IEE Colloquium on Image Processing and Multimedia - Collaborative Projects and Funding Opportunities. IEE, 1997. http://dx.doi.org/10.1049/ic:19971209.
Full text
9
McCoy, Christine. "Fishing for Energy Partnership Cleans up Marine Debris Pollution and Promotes Benefits of Recycling and Energy-From-Waste." In 18th Annual North American Waste-to-Energy Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/nawtec18-3523.
Full textAbstract:
Fishing for Energy (FfE) is a partnership of Covanta Energy Corporation, the National Fish and Wildlife Foundation (NFWF), the National Oceanic and Atmospheric Administration’s (NOAA) Marine Debris Program, and Schnitzer Steel Industries, Inc. The purpose of the FfE partnership is to provide fishermen with a no-cost disposal option for old or derelict fishing gear and to convert it into clean, renewable energy, using state-of-the-art Energy-from-Waste technology. To date, nearly 270 tons of gear has been collected, metals are recovered for recycling, and the rest has generated approximately 330 MWh of electricity.
10
Miyazaki, Katsumasa, and Koichi Saito. "Ductile Fracture Strength of Ni-Based Alloy With an Inch Thickness." In ASME 2010 Pressure Vessels and Piping Division/K-PVP Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/pvp2010-26120.
Full textAbstract:
To develop the failure assessment procedure of Ni-based alloy, the fracture tests of flat plate specimens with a rectangular flaw were conducted at 302°C in temperature. The flat plate specimens were base metal plates, NCF600 and butt weld joints, whose weld metal was Alloy 182 with an inch (25 mm) in thickness. The maximum load at 302°C could be estimated by the limit load analysis (LLA) and twice elastic slope (TES) method with finite element analysis. In addition, the difference between maximum load obtained by the fracture tests and estimations by LLA and TES method became smaller with increasing the flaw area. The net stress at the maximum load depends on the flaw depth and this tendency in Ni-based alloy at 302°C is almost the same as the Hasegawa’s experimental proposal obtained by the fracture tests of austenitic stainless steel.
Reports on the topic "Inc TNS"
1
Hartmann, R. Default Port for Internet Relay Chat (IRC) via TLS/SSL. RFC Editor, August 2014. http://dx.doi.org/10.17487/rfc7194.
Full text
2
Smith, K. L. CAD data exchange with Martin Marietta Energy Systems, Inc., Oak Ridge, TN. Office of Scientific and Technical Information (OSTI), October 1994. http://dx.doi.org/10.2172/135045.
Full text
3
Bedoya-Maya, Felipe, Lynn Scholl, Orlando Sabogal-Cardona, and Daniel Oviedo. Who uses Transport Network Companies?: Characterization of Demand and its Relationship with Public Transit in Medellín. Inter-American Development Bank, September 2021. http://dx.doi.org/10.18235/0003621.
Full textAbstract:
Transport Network Companies (TNCs) have become a popular alternative for mobility due to their ability to provide on-demand flexible mobility services. By offering smartphone-based, ride-hailing services capable of satisfying specific travel needs, these modes have transformed urban mobility worldwide. However, to-date, few studies have examined the impacts in the Latin American context. This analysis is a critical first step in developing policies to promote efficient and sustainable transport systems in the Latin-American region. This research examines the factors affecting the adoption of on-demand ride services in Medellín, Colombia. It also explores whether these are substituting or competing with public transit. First, it provides a descriptive analysis in which we relate the usage of platform-based services with neighborhood characteristics, socioeconomic information of individuals and families, and trip-level details. Next, factors contributing to the election of platform-based services modeled using discrete choice models. The results show that wealthy and highly educated families with low vehicle availability are more likely to use TNCs compared to other groups in Medellín. Evidence also points at gender effects, with being female significantly increasing the probability of using a TNC service. Finally, we observe both transit complementary and substitution patterns of use, depending on the context and by whom the service is requested.
4
Rincón-Torres, Andrey Duván, Kimberly Rojas-Silva, and Juan Manuel Julio-Román. The Interdependence of FX and Treasury Bonds Markets: The Case of Colombia. Banco de la República, September 2021. http://dx.doi.org/10.32468/be.1171.
Full textAbstract:
We study the interdependence of FX and Treasury Bonds (TES) markets in Colombia. To do this, we estimate a heteroskedasticity identified VAR model on the returns of the COP/USD exchange rate (TRM) and bond prices, as well as event-analysis models for return volatilities, number of quotes, quote volume, and bid/ask spreads. The data under analysis consists of 5-minute intraday bid/ask US dollar prices and bond quotes, for an assortment of bond species. For these species we also have the number of bid/ask quotes as well as their volume. We found, also, that the exchange rate conveys information to the TES market, but the opposite does not completely hold: A one percent COP depreciation leads to a persistent reduction of TES prices between 0.05% and 0.22%. However, a 1% TES price increase has a very small effect and not entirely significant on the exchange rate, i.e. a COP appreciation between 0.001% and 0.009%. Furthermore, TRM return volatility increases do not affect bond return volatility but its liquidity, i.e. the bid/ask quote number and volume. These results are coherent with the fact that the FX market more efficiently reflects the effect of shocks than the TES market, which may be due to its low liquidity and concentration on a specific habitat. These results have implications for the design of financial stability policies as well as for private portfolio design, rebalancing and hedging.
5
Brooks, Amy, Jenna Jambeck, and Eliana Mozo-Reyes. Plastic Waste Management and Leakage in Latin America and the Caribbean. Inter-American Development Bank, November 2020. http://dx.doi.org/10.18235/0002873.
Full textAbstract:
As of 2017, 8.3 billion metric tons of plastic had been produced worldwide. Since about 40% is used in things that are thrown away relatively quickly (packaging and single use items), 6.4 billion metric tons had already become discarded materials needing to be managed. Only 9% of these discarded materials were recycled globally. The annual estimate of plastic entering our oceans globally is 5 to 13 million metric tons (MMT) per year. Latin America and the Caribbean (LAC) has an extensive populated coast, 119,000 km of coastline and over 205 million people living within 50 km of that coastline. Waste management infrastructure is still under development in many countries. Economic growth without fully developed infrastructure can lead to increased plastic leakage. This report focuses on municipal solid waste as a source of plastic input into the environment in LAC. The reports estimates that total plastic waste available to enter the ocean in LAC in 2020 was 3.7 MMT . Under business-as-usual projections, the report anticipates that the regional quantity available to enter the oceans in 2030 will be 4.1 MMT and 4.4 MMT in 2050.
6
Reiter, Patrick, Hannes Poier, Christian Holter, Sabine Putz, Werner Doll, Maria Moser, Bernhard Gerardts, and Anna Provasnek. Business Models of Solar Thermal and Hybrid Technologies. IEA SHC Task 55, February 2019. http://dx.doi.org/10.18777/ieashc-task55-2019-0002.
Full textAbstract:
District Heating required annually 600 TWh in the European Union and represents more than 10% of the EUs heat demand. Fossil fuels are the major source for heat production. Approximately 5000 district heating grids in the EU are operated by burning fossil fuels valued at € 18 billion (600 TWh) and emitting more than 150 million tons of CO2 emissions every year.
7
Suhartono, Suhartono, Agoes Soegianto, and Achmad Amzeri. Mapping of land potentially for maize plant in Madura Island-Indonesia using remote sensing data and geographic information systems (GIS). EM International, November 2020. http://dx.doi.org/10.21107/amzeri.2020.1.
Full textAbstract:
Maize productivity in Indonesia was still low (5.241 tons/ha) compared to the average of the ten largest maize producing countries in the world (6.179 tons/ha). The potential for maize on the island of Madura is approximately 360,000 hectares. The potential for maize cultivation in Madura continues to decrease in land quality due to improper land clearing and land-use change. The purpose of this research was to make a map of land suitability for maize using Remote Sensing Data and Geographic Information System (GIS). The land suitability method for maize plants used satellite imagery as a data source, supported by fieldwork and secondary data. Data analysis using Geographic Information Systems (GIS). The results of the analysis of land suitability modeling based on agroecosystem potential found that most of the Madura area was suitable for maize cultivation. Madura island had a land area of 456,622.3ha for maize cultivation, where 170.379.5 (15.4%) was very appropriate, 211.412.3 ha (46.3%) was appropriate, 160,098.6 (35.1%) was less appropriate, and 14,732.0 ha (3.2%) was not appropriate.
8
Muñoz Castillo, Raul, Glen Hearns, Denea Larissa Trejo, and Luis Pabon Zamora. Joined by Water (JbW): IDB's Transboundary Waters Program. Inter-American Development Bank, April 2021. http://dx.doi.org/10.18235/0003201.
Full textAbstract:
This discussion paper scopes out the IDBs initiative to engage in transboundary waters (TW) projects in Latin America and the Caribbean (LAC). The document is organized into four sections: brief history and overview of the TWs approach; international evidence on TW cooperation; a diagnosis of the current situation of TW in LAC; and presents the strategy of the new IADB transboundary water program (Joined By Water) which aims at enhancing the governance and management of transboundary waters in Latin America and the Caribbean (LAC). The document has been prepared in consultation with multiple stakeholders related to transboundary waters issues in LAC.
9
Dahl, Kristina, and Rachel Licker. Too Hot to Work: Assessing the Threats Climate Change Poses to Outdoor Workers. Union of Concerned Scientists, August 2021. http://dx.doi.org/10.47923/2021.14236.
Full textAbstract:
Outdoor workers face severe risks from extreme heat—risks that will increasingly threaten the health and livelihood of tens of millions of outdoor workers in the United States as climate change makes dangerously hot days more frequent and intense. With economic and legal systems that routinely discount their lives and safety, workers who experience heat-related injuries or illnesses on the job have little to no recourse. By midcentury, with no action to reduce global warming emissions, an estimated $37.1 billion in outdoor workers’ earnings would be at risk annually due to extreme heat. Even with bold action to limit emissions, outdoor workers will face severe and rising risks from extreme heat. Policymakers and employers must take actions to protect outdoor workers.
10
Shelley, John. Modeling the effect of increased sediment loading on bed elevations of the Lower Missouri River. Engineer Research and Development Center (U.S.), April 2021. http://dx.doi.org/10.21079/11681/40360.
Full textAbstract:
This US Army Corps of Engineers (USACE) National Regional Sediment Management Technical Note (RSM-TN) documents the effects of increased sediment loading to the Missouri River on bed elevations in the lower 498 miles. This was accomplished using a one-dimensional (1D) HEC-RAS 5.0.7 sediment model.