Journal articles on the topic 'Inca roads'

Guided by modern miners of the region the authors track down pre-Inca mining sites in the Southern Nasca Region of Peru. In the hinterlands away from both modern and ancient roads they find a surprising number of small sites serving the pre-Inca industry, principally in the Nasca period. Drawing analogies from modern practice they are able to distinguish the ancient sites dedicated to exploration, extraction or production.

This article explores the conceptualisation of intangible heritage through the placement of traditional practices, by providing a method for cultural heritage inventories on Indigenous territories. Landscapes of movements is the theory that allows the analysis of Indigenous cultures and territories in terms of context, inhabitants, heritage, policies, traditions, symbolism, landmarks and roads. The case study is Caspana, a Likan Antai community in the north of Chile, incorporated in the Inca roads. Through interviews over a tenure map built in co-labour with the community in study, it was possible to articulate a space signification in relation to people’s movement as a “ritual territory” and an “ancient territory”, one for the present and for past movement, respectively. This tenure map method becomes a tool for the Indigenous communities, who can now use it as argument for claiming their rights over land.

The ancient network of roads in the Andean region is one of the most important works of infrastructure in South America. The extensive territory where the main exchanges between their communities were locally performed is previous to the expansion of the Inca Empire. In the year 2014, the region was included on the World Heritage List by the United Nations Educational, Scientific and Cultural Organization.<br><br> This communication network is the Qhapaq Ñan, Andean Road System. The Incas planned their route in the diverse landscape of the Andes to promote social and economic ties among the Andean communities. The routes originated in the central square of Cusco, creating cross-connections in a wide geographical area. The Tawantinsuyu depended on this sole route to link very distant production and worship centers.<br><br> The Qhapaq Ñan was the result of a political project. Even nowadays, it continues to articulate the development of cultural traditions in the Andean region. The present contribution analyzes its transcendental importance as a Cultural Heritage and the singularity of its nomination by the UNESCO, as for the first time six countries are sharing common objectives towards guaranteeing its protection.<br><br> Furthermore, this research explores the sense of timing in Latin American countries and the implicit challenges in the implementation of the new information technologies for the dissemination of information on Main Andean Road and for its conservation.<br><br> Although many of the countries have already incorporated the necessary digital tools in this matter, we conclude that there is a need to implement an Integrated Digital Model for the coordinated management in the countries that form the region.

Institute of Noise Control Engineering of Japan (INCE/J) proposed a prediction model of road traffic vibration "INCE/J RTV Model 2003". The scope of this prediction model is only for flat roads. Prediction of Road Traffic Vibration subcommittee is trying to expand the scope of application. This paper discussed expand the scope for embankment and cut road with actual measurement. Regarding whether the prediction formula for flat roads can be applied to embankment and cutting roads, It is compared with the actual measurement result of a runnning truck on the cutting road. It also describes inpact tests of ground vibration propagation on cut roads.

Recent advances in computers and software have made it possible to solve in a practical time, even for large-scale 3D FEM models, while considering road bumps and the dynamic interaction between a vehicle and the road. In this study, a 3D FEM road traffic vibration analysis was tried for flat roads, embankment road and cut road. And the results were compared with the predicted values from INCE/J RTV-MODEL 2003. These conclusions will give us useful suggest for the prediction of road traffic vibration.

This paper deals about astronomical orientation of Incas objects in Ollantaytambo, which is located about 35 km southeast from Machu Picchu, about 40 km northwest from Cusco, and lies in the Urubamba valley. Everybody writing about Ollantaytambo, shoud read Protzen (1993). He devoted his monograph to description and interpretation of that locality. Book of Salazar and Salazar (2005) deals, among others, with the orientation of objects in Ollantaytambo with respect to the cardinal direction. Zawaski and Malville (2007) documented astronomical context of major monuments of nine sites in Peru, including Ollantaytambo. We tested astronomical orientation in these places and confirm or disprove hypothesis about purpose of Incas objects. For assessment orientation of objects we used our measurements and also satellite images on Google Earth and digital elevation model from ASTER. The satellite images used to approximate estimation of astronomical orientation. The digital elevation model is useful in the mountains, where we need the really horizon for a calculation of sunset and sunrise on specific days (solstices), which were for Incas people very important. By Incas is very famous that they worshiped the Sun. According to him they determined when to plant and when to harvest the crop. In this paper we focused on Temple of the Sun, also known the Wall of six monoliths. We tested which astronomical phenomenon is connected with this Temple. First, we tested winter solstice sunrise and the rides of the Pleiades for the epochs 2000, 1500 and 1000 A.D. According with our results the Temple isn't connected neither with winter solstice sunrise nor with the Pleiades. Then we tested also winter solstice sunset. We tried to use the line from an observation point near ruins of the Temple of Sun, to west-north, in direction to sunset. The astronomical azimuth from this point was about 5&deg; less then we need. From this results we found, that is possible to find another observation point. By Salazar and Salazar (2005) we found observation point at the corner (east rectangle) of the pyramid by <i>Pacaritanpu</i>, down by the riverside. There is a line connecting the east rectangular "platform" at the river, going along the Inca road up to vicinity of the Temple of the Sun and then in the direction to the Inca face. Using a digital elevation model we found the astronomical azimuth, which is needed for confirm astronomical orientation of the Temple. So, finally we are able to demonstrate a possibility of the solar-solstice orientation in Ollantaytambo.

ABSTRACTTheblaNDM-1gene has been reported to be often located on broad-host-range plasmids of the IncA/C type in clinical but also environmental bacteria recovered from the New Delhi, India, area. IncA/C-type plasmids are the main vehicles for the spread of the cephalosporinase geneblaCMY-2, frequently identified in the United States, Canada, and Europe. In this study, we completed the sequence of IncA/C plasmid pNDM-KN carrying theblaNDM-1gene, recovered from aKlebsiella pneumoniaeisolate from Kenya. This sequence was compared with those of three IncA/C-type reference plasmids fromEscherichia coli,Yersinia ruckeri, andPhotobacterium damselae. Comparative analysis showed that theblaNDM-1gene was located on a widely diffused plasmid scaffold known to be responsible for the spread ofblaCMY-2-like genes and consequently for resistance to broad-spectrum cephalosporins. Considering that IncA/C plasmids possess a broad host range, this scaffold might support a large-scale diffusion of theblaNDM-1gene among Gram-negative rods.

<p>This paper deals with astronomical orientation of Incas objects in Ollantaytambo, which is located about 35 km southeast from Machu Picchu, about 40 km northwest from Cusco, and lies in the Urubamba valley. Everybody writing about Ollantaytambo, shoud read Protzen. (1) He devoted his monograph to description and interpretation of that locality. Book of Salazar and Salazar (2) deals, among others, with the orientation of objects in Ollantaytambo with respect to the cardinal direction. Zawaski and Malville (3) documented astronomical context of major monuments of nine sites in Peru, including Ollantaytambo. We tested astronomical orientation in these places and confirm or disprove hypothesis about purpose of Incas objects. For assessment orientation of objects we used our measurements and also satellite images on Google Earth and digital elevation model from ASTER. The satellite images were used to estimate the astronomical-solar-solstice orientation, together with terrestrial images from Salazar and Salazar (2). The digital elevation model is useful in the mountains, where we need the actual horizon for a calculation of sunset and sunrise on specific days (solstices), which were for Incas people very important. We tested which astronomical phenomenon is connected with objects in Ollantaytambo. First, we focused on Temple of the Sun, also known the Wall of six monoliths. We tested winter solstice sunrise and the rides of the Pleiades for the epochs 2000, 1500 and 1000 A.D. According with our results the Temple isn´t connected neither with winter solstice sunrise nor with the Pleiades. Then we tested also winter solstice sunset. We tried to use the line from an observation point near ruins of the Temple of Sun, to west-north, in direction to sunset. The astronomical azimuth from this point was about 5° less then we need. From this results we found, that is possible to find another observation point. By Salazar and Salazar (2) we found observation point at the corner (east rectangle) of the pyramid by <em>Pacaritanpu,</em> down by the riverside. There is a line connecting the east rectangular “platform” at the river, going along the Inca road up to vicinity of the Temple of the Sun and then in the direction to the Inca face. Using a digital elevation model we found the astronomical azimuth, which is needed for confirm astronomical orientation of the Temple. So, finally we are able to demonstrate a possibility of the solar-solstice orientation in Ollantaytambo.</p>

Abstract. The INCA-CE (Integrated Nowcasting through Comprehensive Analysis – Central Europe) project aims at implementing a transnational weather information system as well as applications for different socio-economic sectors to reduce risks of major economic damage and loss of life caused by severe weather. Civil protection and also stakeholders from economic sectors are in a growing need of accurate and reliable short-term weather forecasts. Within INCA-CE, a state-of-the art nowcasting system (INCA) is implemented at weather services throughout the European Union's CE (Central Europe) Programme Area, providing analyses and short term forecasts to the aforementioned end-users. In a coherent approach, the INCA (Integrated Nowcasting through Comprehensive Analysis) system will be adapted for implementation and use in a number of partner countries. Within transregional working groups, the gap between short-term weather information and its downstream activities in hydrological disaster management, civil protection and road management will be bridged and best practice management and measure plans will be produced. A web-based platform for outreach to related socio-economic sectors will initiate and foster a dialogue between weather services and further stakeholders like tourism or the insurance sector, flood authorities for disaster management, and the construction industry for cost-efficient scheduling and planning. Furthermore, the project will produce a compact guideline for policy makers on how to combine structural development aspects with these new features. In the present paper, an outline of the project implementation, a short overview about the INCA system and two case studies on precipitation nowcasts will be given. Moreover, directions for further developments both within the INCA system and the INCA-CE project will be pointed out.

Geotourism is a concept that is expanding rapidly throughout the world without exception, given its versatility to value the elements of geodiversity and geoheritage; landscape elements without an apparent use or benefit usually find in geotourism a window that can exploit unsuspected conditions. Culebrillas Lagoon, located in the southern center of the Ecuadorian Andes, represents a hydrographic unit of glacio–lacustrine origin as a typical hidden place that conceals a valuable geotourism potential. Culebrillas is marked by a series of fluvio–glacial morphologies, whose forms hide an important cultural heritage expressed in its festivities, myths, and legends which have been celebrated through the centuries. Inca and Cañari civilizations have been, in the past and present, the original groups that inhabited this sector, and important vestiges of their presence are still evident, as in the case of the Qhapaq Ñan or the Inca road system. The present investigation allowed the generating of information about elements of geoheritage and other related resources that have various potential uses, and which highlight the intrinsic values present in this area, complementing each other from a holistic socio–environmental and geotourism perspective.

Numerous studies have explored mobility along the Qhapaq Ñan. Most of them examine how the road influenced local, regional, and imperial dynamics by fostering exchange relationships and connecting societies, people, and territories. These investigations explicitly or implicitly assume that it was male individuals who mobilized to build the Tahuantinsuyo, while women remained within the domestic unit or were confined to imperial buildings. In this study, we seek to acknowledge potential patterns of women’s mobility as part of female collectives, including those identified as acllas (chosen ones) or mamaconas (matrons) within the Tahuantinsuyo territory, through a gender perspective. We do so by drawing on five cases supported by biogenetic data and published textile analysis, as well as ethnohistorical data from Inca llacta cemeteries and capacocha ritual events (a ritual of obligation to the Inca state where infants were offered). We identified modes of movement that consider the distance traveled, the age of female individuals, and the political motives framing each activity, and which, in turn, construct identity, Finally, our analysis indicates that the visualization and analysis of individuals’ mobility experiences are associated with types of movement related to local, regional, or imperial political interests that reveal certain logics of movement that have been hidden, in this case, those of female experiences within the Tahuantinsuyo.

Opening of the Blanka Tunnel Complex (BTC) in Prague, Czech Republic, the longest city tunnel in Europe, significantly increased traffic on a connected main road, the V Holešovičkách street (VHS). To study environmental changes in VHS connected with BTC opening, sampling of road dust and airborne particulate matter in the VHS vicinity started 3 years before BTC opening and continued until BTC pilot operation. The enrichment factors calculated for the collected samples from elemental compositions determined by instrumental neutron activation analysis (INAA) have shown significant enrichment for Se, Sb, Hg, Br, Mo, Zn, As, W, Cr, Ba, and Fe, but not their increase after starting BTC operation. The Principal Component Analysis allowed distinguishing between detrital and anthropogenic, probably traffic related, origin of the elements determined in samples. The study demonstrated a potential of INAA for multielement trace analysis of minute samples (28 elements determined in samples down to 20 μg, with detection limits down to sub-ng level) and its application in urban geochemistry studies.

CairnsIn Denmark, the term stenkast (a ‘stone throw’) is used for cairns – stone heaps that have accumulated in places where it was the tradition to throw a stone. A kast (a ‘throw’) would actually be a more correct term, as sometimes the heaps consist of sticks, branches, heather, or peat, rather than stones – in short, whichever was at hand at that particular place. A kast could also consist of both sticks and stones.The majority of the known Danish cairns were presented by August F. Schmidt in 1929. Since then, numerous new ones have been discovered, and we now know of around 80 cairns, cf. the list on page 264 and map Fig. 3. It appears from the descriptions that the majority – a total of 65 – are actual cairns, 14 are heaps of branches, whereas two are described as either peat or heather heaps.Geographically, the majority – a total of 53 – are found in Jutland, with most in North and Central Jutland (Fig. 3). Fifteen are known from Zealand, four from Lolland, four from Funen, and five from Bornholm.Topographically, they are found – naturally – where people would normally be passing: next to roads and in connection with sacred springs, chapels, and places of execution. However, they also occur in less busy places, in woods, along the coast, on moors, and on small islands.A few cairns have been preserved because they are still “active” as reminiscences of customs and habits of past times. This is the case of the cairn called Røsen (“røse” being another Danish term for a cairn) on Trøstrup Moor (no. 45, Fig. 1-2), of Heksens Grav (“The Witch’s Grave”) (no. 27, Fig. 4), and of the branch heap in the wood of Slotved Skov (no. 14, Fig. 5), which was recently revived after having been almost forgotten. Other cairns are maintained as prehistoric relics, as is the case of the branch heap by the name of Stikhoben (“The Stick Heap;” no. 10, Fig. 6) and Kjelds Grav (“Kjeld’s Grave,” no. 59, Fig. 7). Although heaps of stones and branches are included in the Danish Protection of Nature Act as relics of the past worthy of protection, so far merely the two latter have been listed.Whereas the remaining ’throws’ of organic material have probably disintegrated, it is still possible under favourable conditions to retrieve those made from more enduring materials – unless they have been demolished – even if they have practically sunk into oblivion (Figs. 8-10).The oldest known cairn is almost 500 years old. It was situated by the ford Præstbjerg Vad in Vinding parish near the Holstebro-Ribe highroad. Tradition says that the stone heap came into existence as a memorial of a priest in Hanbjerg, who died in the first half of the 16th century following a fall with his horse.Such legends of origin are connected with most of the Danish cairns. They usually tell of some unhappy or alarming happening supposed to have occurred at the place in question. However, they are often so vague and stereotype that they can only rarely be dated or put into a historical context. Indeed, on closer examination several of them turn out to be travelling legends. Apart from the legend of the murdered tradesman, they comprise the legend of the exorcised farmhand and that of the three sisters, who were murdered by three robbers, who turned out to be their own brothers. The latter legend, which is also known from a folksong, is connected to the so-called Varper on the high moor in Pedersker parish on Bornholm (no. 7). Until the early 20th century, it was the custom to maintain these cairns by putting back stones that had fallen down and adorn them with green sprigs. Early folklorists interpreted this as a tradition going back to an old sacrificial ritual, although the custom also seems to have had a pure practical purpose, as these stone heaps were originally cairns marking the road across inland Bornholm.A special group of the Danish cairns are connected with the tradition that someone is buried underneath them, such as a body washed ashore, a murdered child from a clandestine childbirth, a murdered person, several persons killed in a fight, an exorcised farmhand, a suicide, a murderer buried on his scene of crime, or witches and murderers buried at the place of execution. In all these cases, the throwing of a stone was supposed to protect the passers-by against the dead, who was buried in unconsecrated grounds and thus, according to public belief, haunted the spot. Another far less frequent explanation was that the stone was thrown in order to achieve a good journey or luck at the market. In some places, the traveller would throw the stone while shouting a naughty word or in other ways showing his disgust with the dead witch, criminal, or infanticide buried in that particular place. In rather a lot of the cases, as explained by the context, the cairn was merely a memorial to some unhappy occurrence, and the stone was thrown in memory of the deceased.In an article on Norwegian cairns written by the folklorist Svale Solheim, the author attached importance to achieving a clear picture of the position of the cairns (kastrøysarne) in the landscape. A closer examination showed that almost all were situated by the side of old roads – between farms and settlements, through forests, or across mountains – in short, where people would often walk. “The cairns follow the road as the shadow follows the man,” Solheim writes and gives an example of an old road, which had been relocated, and where the cairns had been moved to the new road. Furthermore, the position of the cairns along the roads turned out to not be accidental; they were always found at places that were in one way or other interesting to the travellers. This is why Solheim thought that the stone heaps mostly had the character of cairns or road stones thrown together at certain places for a pure practical purpose. “For instance,” he writes, “we find stone heaps at places along the roads where there is access to fine drinking water. These would also be natural places for a rest, and numerous stone heaps are situated by old resting places. And so it came natural to mark these places by piling up a stone heap, and of course it would be in every traveller’s interest to maintain the heaps.”The older folklore saw the tradition as a relic of pagan rituals and conceptions. As a reaction to this, Solheim and others took a tradition-functionalistic view, according to which most folklore, as seen in the light of the cultural conditions, was considered rational and the rest could be explained as pseudo beliefs, for instance educational fiction and tomfoolery.However, if we turn to our other neighbouring country, Sweden, it becomes more difficult to explain away that we are dealing with sacrificial rites, as here, the most used dialectal term for the stone and branch piles were offerhög, offervål, or offerbål (“offer” is the Swedish word for sacrifice), and when someone threw stones, sticks, or money on the pile, it was called “sacrificing.” An article from 1929 by the anthropologist Sigurd Erixon is especially interesting. Here, he documents how – apart from the cairns with a death motive (largely corresponding to the Danish cases mentioned above), Sweden had both good luck and misfortune averting sacrificial stone throwing (Fig. 13).Whereas the sacrificial cairns connected to deaths were evenly distributed across the whole country, Erixon found that the “good luck cairns” occurred mainly in environments associated with mountain pasture farming or fishing. Based on this observation and desultory comparative studies, Erixon formed the hypothesis that the “good luck cairns” represented an older and more primitive culture than the cairns associated with sacrifices to the dead. “The first,” he writes, “belong rather more to the work area of hunting, fishing, and animal husbandry, roads, and environments, whereas the death sacrificial cairns seem to be closer related to the culture of agriculture.”The problem with the folkloristic material is that most of it is based on reminiscences. In order to study the living tradition, one must turn elsewhere. However, as demonstrated by James Frazer in “The Golden Bough,” this is no problem, as the custom of throwing stones in a pile is known from all over the world, from Africa, Europe, and Asia to Australia and America (Fig. 14).Customs last, their meanings perish – the explanation why, for instance, one must throw a stone onto a stone pile, may be forgotten, or reinterpreted, or get a completely new explanation. The custom probably goes back further than any known religion. However, these have all tried to tally the stone throwing with their “theology.” In Ancient Greece, the stone piles by the roadsides were furnished with statues of Hermes (in the shape of a post with a head and sometimes a phallus). As an escort for the dead, Hermes became the god of the travellers, and just as the gods had thrown stones after Hermes when he was accused of murdering Argus, people could now do the same.With the introduction of Christianity, the throwing of stones was denounced as superstition, and a standard question for the penitents in the so-called books of penance was: “Have you carried stones to a heap?” All across Europe, crosses were planted in the stone heaps – which must have caused problems as it was considered a deadly sin to throw stones after a cross. In the culture connected with pilgrimage, the cairns got a new meaning as markers of important places. For instance, enormous stone piles outside Santiago de Compostela mark the location where pilgrims first spotted the towers of the city’s cathedral (Fig. 15). At many places, the cairns were consecrated to saints, so that now people would carry stones to them as a sacrifice or a penance. The jews also adopted the custom. The Old Testament mentions stone heaps gathered over murdered persons or placed around a larger stone, as the “witness dolmen” built by Jacob and his people to commemmorate his pact with Laban, his father-in-law. However, there is no mention of throwing new stones onto these heaps. However, the latter occurs in the still practiced Jewish custom of placing stones on the gravestones when Jews visit the graves of their dead (Fig. 16).Stone throwing in a Muslim context is illustrated by Edward Westermarck’s large investigation of rituals and popular belief with the Berbers and the Arabs in Marocco in the early 20th century. Unfortunately, it only comprises cairns connected to Muslim saints, but even with this limitation, the investigation gives an idea of the variety of applications. If the stone heap is situated near the grave of a saint, it may mark the demarcation of the sacred area, or it may have come into existence because the wayfaring have a habit of throwing a stone when they pass the grave of a saint, which they do not have time to visit. If the heap is situated on a ridge, it is usually an indication of the spot on a certain pilgrim route where the sacred places become visible for the first time. Other stone heaps mark the places where a holy man or woman is supposed to have been buried, or rested, or camped some time. By a large crossroads outside Andira, Westermark was shown a stone heap, which indicated that this place was the gathering place for saints, who met there at nighttime. The sacred cairns in Marocco are often easily recognized by the fact that they are chalked white at intervals. At some places, the cairns may also be marked with a pole with a white flag symbolising the sacred character of the place.Even Buddhism struggled against the stone heaps, especially in the form of the oboo cult, which was repeatedly reformered and reinterpreted by Buddhist missionaries. And in early 17th-century South America, the converted aristocratic Inca, Felipe Guaman Poma de Ayala, made sarcastic remarks about Indians, who “even now” had preserved the bad habit of [sacrificing to] stone heaps (apachitas).”Historically, the Danish cairns can be documented from the 16th century, but the tradition may well be older. Seen in a larger, comparative context, heaps of stones and branches represent an ancient tradition rooted in the deepest cultural layers of mankind. Thus, as cultural relics, they are certainly worthy of preservation, and we ought to put a lot of effort into preserving the few still existing.Whereas it will probably be difficult to establish possible prehistoric stone heaps using archaeology, the possibilities of documenting hitherto unknown stone piles from historical times is considerably higher, if special topographic conditions are taken into consideration. In connection with small mounds on tidal meadows or stone heaps along stretches of old roads and by fords, old places of execution, springs, and grave mounds used secondarily for gallows, one should pay attention to such structures, which may well prove to be covering a grave.In a folklore context, the Danish stone heaps must be characterized as mainly “death sacrifice throws,” whereas only few were “good luck throws.” Due to the limited size of the country, and early farming, cairns and other road marks have not played the same role as a help for travellers and traffic as it did in our neighbouring countries with their huge waste areas.If the stone piles are considered part of a thousands of years old chain of traditions, they belong to the oldest human “monuments.” The global distribution of the phenomenon endows it with a mystery, which, during a travel in Mongolia, Haslund-Christensen caught with a stroke of genius: “We stood before an oboo, one of the largest I have ever seen...one of those mysterious places of sacrifice which are still secretly preserved, built of stone cast upon stone through many generations; a home of mystery which has its roots in the origin of the people itself, and whose religious significance goes much further back in time than any of the religions in the modern world.”Gustav HenningsenDansk Folkemindesamling Jesper LaursenMoesgård Museum Translated by Annette Lerche Trolle

Abstract. In this study, the LMDz-INCA climate-chemistry model and up-to-date global emission inventories are used to investigate the "present" (2000) and future (2050) impacts of transport emissions (road traffic, shipping and aircraft) on global tropospheric ozone. For the first time, both impacts of emissions and climate changes on transport-induced ozone are investigated. The 2000 transport emissions are shown to mainly affect ozone in the Northern Hemisphere, with a maximum increase of the tropospheric column of up to 5 DU, from the South-Eastern US to Central Europe. The impact is dominated by road traffic in the middle and upper troposphere, north of 40° S, and by shipping in the northern lower troposphere, over oceanic regions. A strong reduction of road emissions and amoderate (B1 scenario) to high (A1B scenario) increase of the ship and aircraft emissions are expected by the year 2050. As a consequence, LMDz-INCA simulations predict a drastic decrease in the impact of road emissions, whereas aviation would become the major transport perturbation on tropospheric ozone, even in the case of avery optimistic aircraft mitigation scenario. The A1B emission scenario leads to an increase of the impact of transport on zonal mean ozone concentrations in 2050 by up to +30% and +50%, in the Northern and Southern Hemispheres, respectively. Despite asimilar total amount of global NOx emissions by the various transport sectors compared to 2000, the overall impact on the tropospheric ozone column is increased everywhere in 2050, due to a sectoral shift in the emissions of the respective transport modes. On the opposite, the B1 mitigation scenario leads to asignificant reduction (by roughly 50%) of the ozone perturbation throughout the troposphere compared to 2000. Considering climate change, and according to scenario A1B, a decrease of the O3 tropospheric burden is simulated by 2050 due to climate change (−1.2%), whereas an increase of ozone of up to 2% is calculated in the upper troposphere in the inter-tropical zone, due to enhanced lightning activity. A global impact of similar magnitude is simulated for the transport-induced ozone burden perturbation (−1.6%). As a result, the future increase in global ozone due to changes in anthropogenic emissions is lowered by 12% and by 4%, for the background and the transport-induced ozone, respectively. However, positive and negative climate effects are obtained on ozone, depending on the season, region and altitude, with an increase of the transport-induced ozone perturbation (+0.4 DU) in the already most affected area of Northern Hemisphere.

Abstract. In this study, the LMDz-INCA climate-chemistry model and up-to-date global emission inventories are used to investigate the "present" (2000) and future (2050) impacts of transport emissions (road traffic, shipping and aircraft) on global tropospheric ozone. For the first time, both impacts of emissions and climate changes on transport-induced ozone are investigated. The 2000 transport emissions are shown to mainly affect ozone in the Northern Hemisphere, with a maximum increase of the tropospheric column of up to 5 DU, from the South-eastern US to Central Europe. The impact is dominated by road traffic in the middle and upper troposphere, North of 40° S, and by shipping in the northern lower troposphere, over oceanic regions. A strong reduction of road emissions and a moderate (B1 scenario) to high (A1B scenario) increase of the ship and aircraft emissions are projected by the year 2050. As a consequence, LMDz-INCA simulations predict a drastic decrease in the impact of road emissions, whereas aviation would become the major transport perturbation on tropospheric ozone, even in the case of a very optimistic aircraft mitigation scenario. The A1B emission scenario leads to an increase of the impact of transport on zonal mean ozone concentrations in 2050 by up to +30% and +50%, in the Northern and Southern Hemispheres, respectively. Despite a similar total amount of global NOx emissions by the various transport sectors compared to 2000, the overall impact on the tropospheric ozone column is increased everywhere in 2050, due to a sectoral shift in the emissions of the respective transport modes. On the opposite, the B1 mitigation scenario leads to a significant reduction (by roughly 50%) of the ozone perturbation throughout the troposphere compared to 2000. Considering climate change, and according to scenario A1B, a decrease of the O3 tropospheric burden is simulated by 2050 due to climate change (−1.2%), whereas an increase of ozone of up to 2% is calculated in the upper troposphere in the inter-tropical zone, due to enhanced lightning activity. A global impact of similar magnitude is simulated for the transport-induced ozone burden perturbation (−1.6%). As a result, the future increase in global ozone due to changes in anthropogenic emissions is lowered by 12% and by 4%, for the background and the transport-induced ozone, respectively. However, positive and negative climate effects are obtained on ozone, depending on the season, region and altitude, with an increase of the transport-induced ozone perturbation (+0.4 DU) in the already most affected area of Northern Hemisphere.

The challenges encountered during the assessment of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) are many. Ideally, CIDP outcome measures capture impairments in disability, strength, and sensory dysfunction, and quality of life (QoL). A number of outcome measures have been validated for this purpose. Disability outcomes include the adjusted inflammatory neuropathy cause and treatment (INCAT) disability score, INCAT overall disability sum score (ODSS), and overall neuropathy limitations scale (ONLS). A more sensitive disability score, the inflammatory Rasch-built overall disability scale (I-RODS), has also been validated for use in clinical trials and may better capture clinically meaningful changes in those with CIDP. Strength and sensory impairment can be assessed in a number of ways, including the INCAT sensory subscore (ISS), Medical Research Council sum score, and Martin vigorimeter or Jamar dynamometer grip strength. However, the feasibility of applying and interpreting these measures during routine daily practice has been questioned. Furthermore, these outcome measures may not reflect other factors that can impair QoL in those affected by CIDP, such as pain and fatigue. A valid, reliable, and responsive composite measure that addresses all aspects of impairment faced by patients with CIDP remains an unmet need in clinical practice.

This work reveals the cultural and tourism poten-tial of the Republic of Moldova – an old prov-ince of ancient free Dacians. In this area of southeastern Europe National Travel Program “The Wine Road” was adopted. Its purpose is the extension of international routes, the devel-opment of tourism infrastructure, the promotion of local customs and culture, including the col-laboration with the neighbor countries. Traveling on the Centre and Nord there could be seen the natural protected areas, churches, museums and monuments of that region. The wine country Moldova is very beautiful, so we are waiting to say you «Welcome to Moldova! »

This article describes nearly 50 years of social and economic development and changes that have occurred in the 4 villages of the Institute of Nutrition of Central America and Panama (INCAP) Longitudinal Study (1969-1977). In doing so, it contextualizes the changes in health and nutrition for the study population over that period. Since the start of the INCAP Longitudinal Study, the original 4 villages, like their home country, have undergone tremendous demographic, social, and economic change. Originally rather isolated, road and transportation access for the villages has improved steadily and substantially. The population in the villages has more than doubled. Schooling access and outcomes have also improved substantially, with average grades of schooling tripling and literacy doubling, reaching levels currently on par with national averages. Occupations have also changed over the course of a generation. Early on, subsistence farming and agriculture in general were dominant but are now much less common. Much of this change is associated with declining agricultural markets alongside increased access to nonagricultural jobs near the villages and in the capital. With all these changes have come improvements in living standards. It is within this dynamic context that study participants for the INCAP Longitudinal Study were born and raised and where most now live as adults.

RESUMENEste artículo presenta una crítica arquitectónica al resultado de la obra de Recuperación y Puesta en Valor del Puente de La Almudena en la ciudad de Cusco, culminada el año 2006. Dicho proyecto parte de la idea general de recuperar físicamente la trayectoria histórica de los caminos pertenecientes al sistema vial inca Qhapaq Ñan, que alguna vez fue la primordial herramienta de integración del entonces Tawantinsuyu. La ejecución de este proyecto significó la renovación de un espacio en franco proceso de deterioro e insalubridad, así como la reapertura del acceso por medio del cual el centro histórico de la ciudad de Cusco se comunica con los territorios del Kuntisuyu o territorios hacia la costa, intervención durante la cual tuvieron lugar nuevos retos y experiencias metodológicas, además de que se gestó una nueva forma de concebir el valor del patrimonio civil público de carácter vial, hasta entonces poco apreciado.PALABRAS CLAVEQhapaq Ñan, puesta en valor, revitalización urbanaABSTRACTThis article presents an architecture critique about the result of the La Almudena Bridge Restoration and Value Enhancement project in the city of Cusco, which ended the year 2006. Said project starts from the idea of physically recovering the historical Inca road system, the Qhapaq Ñan, that was once the crucial integration tool of the then empire of the Tawantinsuyu. The realization of the project also meant the renovation of a space under a marked deterioration and insalubrity process. As well, it caused the reopening of the access through which Cusco communicates with the Kuntisuyu, or coastal, territories. Unexpected challenges and new methodological experiences appeared during the intervention, and a new way to understand the value of public civil transportation heritage was born, previously not truly appreciated.KEYWORDSQhapaq Ñan, Value enhancement, Urban renewal

As designers, we should question ourselves on how we relate to the ground. In this article, we would re-trace urban landscape lines of the Qhapaq Ñan, the Inca Andean Road system in Peru, to reveal the primeval pattern that a city extends; we shall explore it through a series of conceptual layers. We inhabit a territory that is facing big changes, and this is taking us towards to the dispel of ecological and archaeological vestiges which are information layers that can lead us to explore the territory. We seek to re-trace a multidimensional system of lines and points, adopting an exploratory and descriptive approach that responses to different strata that allow us to become aware of the landscape. Within observing the systems revealed, we can understand and appreciate the natural and urban landscapes intertwined in a city morphology to operate upon it, for us to propose new alternatives to integrate our heritage to the existent urban landscape.

Abstract This essay addresses the specific indigenous identity of Indian women resettled in colonial La Plata, particularly those associated with mercantile trades and consequently involved in the creation of colonial markets. The search for Indian women’s urban identities rests upon the material culture associated with labor activities and social standing among those recently settled in the Spanish urban milieu. Objects and places, goods and spaces can be manipulated, reappropriated, and reinterpreted by new social actors on their road to history. Things have meaning and are bound to culture and identity. In this way, indigenous women’s dress and adornment are associated with the dramatic changes brought about by the new mercantile economy introduced by the Spaniards. Indian women who resettled in the city and gained economic success pursuing mercantile trades adopted distinctive components of female dress. These styles evoked both the recent Inca past and certain elements of Spanish attire and adornment that forged a specific identity associated with a specific trade, asserting a newly acquired status in the emerging colonial society

On Prediction of Road Traffic Vibration of INCE/J Technical Subcommittees, we are studying the creation of prediction formulas for vibration from embankments and cuts and vibration from bridges. This paper presents the concept of a simplified method for predicting road traffic vibration from viaducts. When large vehicle runs on viaduct, vibration occurs in the floor slab and propagates from the piers and foundation to the ground. Here, the reference waveform at the bottom of the pier is used as the reference point unit pattern, and the vibration propagates from the bottom of each pier on the plane to the ground surface, and a method of calculating the combined value at the prediction point is considered, and the establishment of a prediction method is examined. bottom. In addition, we will report on the results of an attempt to predict the vibration propagation situation to the surroundings for a large vehicle test run and compare it with the actual measurement value. In addition, we examined the calculation procedure assuming traffic flow conditions in this model.

A greatly enlarged physical model of the interface between ameloblasts and enamel facilitates the discussion of factors which might be involved in the control of the development of crystal orientation patterns and the prisms (or rods) in dental enamel. The model specifically relates to the most common circumstances in human enamel development. The 3-D concepts grasped from the developmental model help to explain the fracture mechanics of the adult tissue.

The present study investigates the use of machine learning algorithms to estimate the state of health (SOH) of high-voltage batteries in electric vehicles. The analysis is based on open-circuit voltage (OCV) measurements from 12 vehicles with different mileage conditions and focuses on establishing a correlation between the OCV values, the energy stored in the battery, and the battery SOH. The experimental campaign was conducted at the Hyundai Motor Europe Technical Center GmbH (Germany), and the data collection process took advantage of the ETAS Integrated Calibration and Application Tool (INCA) and the ETAS Measure Data Analyzer (MDA) software. Six machine learning algorithms are evaluated and compared, namely linear regression, k-nearest neighbors, support vector machine, random forest, classification and regression tree, and neural network. Among the evaluated algorithms, random forest (RF) exhibits the best performance in predicting the state of health of high-voltage batteries, both for the OCV and the capacity (C) estimation. Specifically, if compared to the worst algorithm (i.e., linear regression), RF achieves a remarkable improvement with a reduction of 96% and 97% in the mean absolute error for the OCV and the C estimation, respectively. Furthermore, the comparison highlighted the main differences in the performance, complexity, interpretability, and specific features of the six algorithms. The findings of the present study will contribute to the development of efficient maintenance strategies, thus reducing the risk of unexpected battery failures.

Exploitation of the extensive polymetallic deposits of the Andean Altiplano in South America since precolonial times has caused substantial emissions of neurotoxic lead (Pb) into the atmosphere; however, its historical significance compared to recent Pb pollution from leaded gasoline is not yet resolved. We present a comprehensive Pb emission history for the last two millennia for South America, based on a continuous, high-resolution, ice core record from Illimani glacier. Illimani is the highest mountain of the eastern Bolivian Andes and is located at the northeastern margin of the Andean Altiplano. The ice core Pb deposition history revealed enhanced Pb enrichment factors (EFs) due to metallurgical processing for silver production during periods of the Tiwanaku/Wari culture (AD 450–950), the Inca empires (AD 1450–1532), colonial times (AD 1532–1900), and tin production at the beginning of the 20th century. After the 1960s, Pb EFs increased by a factor of 3 compared to the emission level from metal production, which we attribute to gasoline-related Pb emissions. Our results show that anthropogenic Pb pollution levels from road traffic in South America exceed those of any historical metallurgy in the last two millennia, even in regions with exceptional high local metallurgical activity.

The present research is a contribution to the quality of life of the communities of the province of Carchi-Ecuador, immersed in the Qhapaq Ñan, or Camino del Inka. This historical route is a national priority for tourist-cultural and scientific development, being declared a World Heritage Site by UNESCO. The objectives that guided the research were: (a) Characterize the geo-historical, social, environmental, political and economic context of the communities immersed in the Qhapaq Ñan of the province of Carchi; (b) Know the ancestral knowledge of older adults located in the Qhapaq Ñan. The qualitative research, descriptive and field type was aimed at 57 adults aged between 75 and 85 years old with good health, retentiveness, narrative predisposition and native of the cantons: Tulcán, Huaca, Montufar and Mira. An in-depth interview was applied through participant observation. The information obtained was recorded in audio and poured into matrix-thematic files of the INPC Cultural Heritage Institute for its interpretation. The results obtained were: the section of the Qhapa Ñan is in the collective memory of the elderly, who know him as the "old way", in Huaca it has disappeared, and in other cantons it is in the process of disappearing; stories, legends, andean medicine, traditional games, couplets, typical gastronomy, crafts, religious festivals, and traditional ones present in the collective memory of older adults were collected. The road contains the history of the Andean towns of Carchi, and constitutes an important intangible heritage to cultural-local tourism.

Cathodic protection is a thermodynamic corrosion control method using metal as the cathode. There are two methods of cathodic protection, namely Sacrificial Anode Cathodic Protection (SACP) and Impressed Current Cathodic Protection (ICPP). This study will analyze the use of Cathodic Protection with the Sacrificial Anode method as corrosion control on a 16 inch oil pipe at PT. Chevron Pacific Indonesia. Carbon steel pipe (API 5L Grade B) with cast magnesium anode material. Calculation of anode requirement for corrosion prevention will be compared with actual field data within 10 years. The calculation results show that the number of calculation parameters used affects the results of the anode requirement on an oil pipe with a length of 16 meters, a diameter of 16 inches, anode with a length of 0.648 m, net weight of anode 7.7 Kg, magnesium anode material with an anode output of 10.8 A/m2, anode density 1765 Kg/m3, wear and tear (volume) 2296 x 10-3 m3 A/y, and a life time of 10 years. Theoretical calculations get 6 anode rods while the actual data requires 8 anode rods.

When starting the second issue, We are pleased to share with you the second issue of the "Journal of Interior Design and Academy" (INda) which has started to be published on May 19, 2021 within the scope of Octagon Academy. INda as a magazine which started to be published despite all the negativities caused by the pandemic during the Covid-19 epidemic, continued its academic contributions with the "Online Chats with INda Series" after the first issue. Under the moderation of Assoc. Dr. Osman ARAYICI who is one of the field editors of our magazine, 8 different online chats were broadcast live on an international and national scale with experts in their fields during October and November. INda as a magazine with the aim of making versatile contributions to our country, universities, the field of interior architecture and related disciplines and professionals working in this field through the production and sharing of scientific knowledge, would like to thank you for the interest and support it has received in these studies in its first year. Obviously, there are many feelings to tell about INda, but now in the second issue, 5 articles presented by 9 authors are listed below. BEKAR and DERECİ examine the subject of refunctioning in traditional civil architecture examples in their article titled “Evaluation of The Appropriateness of Space for The New Function in Traditional Housings: The Case of Mehmet Efendi House”. In particular, Mehmet Efendi Mansion evaluates the old space-new function suitability under two headings as "functional spatial suitability" and "environmentally functional suitability". ÇELENK and SÜRDEM's article titled “Continuity of Cultural Memory: From Samsun Tekel Tobacco Factory to Bafra Tobacco Museum” examines the re-functionalization process. The formal and semantic analyzes of the two structures are presented by making comparisons. ERBAY, in the article titled "Balcony as An Architectural Item", makes an inference over the semantic values ​​that “Balcony” covered during the pandemic process that started with the Covid-19 outbreak. ERBAY and ULUSOY examine the “sense” as a term in interior space in their article titled “Senses in The Interiors: An Example of Entrance Spaces at Hospitals”. In the article, the general design principles have been tried to be reached through the given example, and the design tools that can appeal to the senses in the interior are revealed. ATMACA and REYHAN discuss the Cultural Road Project within the scope of adaptive reuse in their article titled “Adaptive Reuse in Restored Historic Buildings: A Field Study in Ünye”. While examining the historical development and architectural features of the selected sample structures, the evaluation of restoration and all perspectives of adaptive reuse that completes this evaluation contributes to the literature. We would like to thank all authors for their contributions to academic production in our field and all our readers for their support. As INda, we welcome all your comments, contributions and suggestions about us. Enjoy our December 2021 issue… Happy New Year…

Background: Peripheral neuropathy (PN) occurs in 20-25% of patients with an IgM paraprotein and up to 50% of these patients have an anti-myelin associated glycoprotein (MAG) antibody which is frequently associated with sensory ataxia and distal limb weakness negatively affecting function and quality of life. While rituximab is active, its activity is limited as a monotherapy and often associated with an IgM flare that can potentiate PN. BTK-inhibitors can block rituximab-associated IgM flare and are proven to markedly reduce serum IgM in Waldenström's Macroglobulinemia (WM). We therefore initiated this trial to evaluate a novel treatment for anti-MAG PN. Methods: We initiateda prospective, single-arm phase II study of acalabrutinib and rituximab (NCT05065554). Patients with an anti-MAG antibody with an IgM monoclonal gammopathy or WM; and a predominantly sensory demyelinating PN with a modified Rankin score of ≥1 with progressive symptoms or a score of ≥2 are eligible. Treatment consists of continuous oral acalabrutinib (100 mg twice daily) with rituximab weekly in cycles 1 and 4. Each cycle is 28 days. The primary endpoint is to evaluate the hematologic response rate. The key secondary endpoint is to evaluate the proportion of patients that achieve improvement or stability in PN based on the Inflammatory Rasch-built Overall Disability Scale (I-RODS) patient-reported disability scale. Additional secondary neurologic endpoints include the Inflammatory Neuropathy Cause and Treatment (INCAT) disability score, MRC distal sum score, INCAT sensory sum score, and a neuropathy-specific quality of life scale (IN-QOL). We hypothesize that 75% of participants (H1) will have a hematologic response versus a null (H0) of 50% or lower. With 33 evaluable patients, there will be 82% power to detect a significant difference with an alpha (2-sided) of 0.04. Results: Eight patients, including 4 females, have enrolled as of July 1, 2023. The median age is 70 years (range 65-76), and median ECOG is 1. Median I-RODS score at baseline was 41 (range 23-48; 48 = no disability). All patients have an IgM kappa paraprotein with median baseline serum IgM of 975 mg/dL (range 226-2137), kappa free light chain of 28 mg/L (range 16-47), and M-spike of 0.6 g/dL (range 0.17-1.1). Anti-MAG antibody titer range is 1:70,000 to 1:819,200 IU/L. Bone marrow biopsy showed no disease in 4 patients, a clonal plasma cell population in 1 patient, and lymphoplasmacytic infiltrate in 3 patients. No adenopathy or splenomegaly were detected on baseline CT scans. Six patients (75%) are MYD88 mutated and none CXCR4 mutated. Five patients had prior rituximab therapy and two received prior IVIG. With a median time on treatment of 175 days (range 28-510), the overall response rate among 7 evaluable patients using IWWM-11 criteria was 86%. Categorical responses include 2 very good partial responses (≥90% decrease in IgM, or normalization of IgM with persistent IgM monoclonal protein); 1 partial response (≥50% but &lt;90% decrease in IgM); 3 minor responses (≥25% but &lt;50% decrease in IgM) and 1 stable disease. Four of 7 patients (57%) had improvement in the I-RODS score. Median improvement was 0.5 points (range -4 to 11). One patient was removed from the trial after 28 days due to grade 3 elevation in ALT. Two other reversible grade 3 adverse events occurred including rituximab related infusion reaction and syncope unrelated to treatment. Conclusions: The combination of acalabrutinib and rituximab has demonstrated activity in this first prospective study that is evaluating BTK-inhibition with CD20 directed therapy in patients with IgM related anti-MAG PN. Hematologic responses occurred in 86% of patients and 57% had an improvement in the I-RODS score. Treatment is well tolerated. Additional data from more detailed neurologic assessments are forthcoming. The trial continues to enroll patients. Our findings provide a framework to develop novel, more effective treatment options for anti-MAG PN.

Abstract. Our previously published paper (Permadi et al. 2018) focused on the preparation of emission input data and evaluation of WRF–CHIMERE performance in 2007. This paper details the impact assessment of the future (2030) black carbon (BC) emission reduction measures for Southeast Asia (SEA) countries on air quality, health and BC direct radiative forcing (DRF). The business as usual (BAU2030) projected emissions from the base year of 2007 (BY2007), assuming “no intervention” with the linear projection of the emissions based on the past activity data for Indonesia and Thailand and the sectoral GDP growth for other countries. The RED2030 featured measures to cut down emissions in major four source sectors in Indonesia and Thailand (road transport, residential cooking, industry, biomass open burning) while for other countries the Representative Concentration Pathway 8.5 (RCP8.5) emissions were assumed. WRF–CHIMERE simulated levels of aerosol species under BAU2030 and RED2030 for the modeling domain using the base year meteorology and 2030 boundary conditions from LMDZ-INCA. The extended aerosol optical depth module (AODEM) calculated the total columnar AOD and BC AOD for all scenarios with an assumption on the internal mixing state. Under RED2030, the health benefits were analyzed in terms of the number of avoided premature deaths associated with ambient PM2.5 reduction along with BC DRF reduction. Under BAU2030, the average number of the premature deaths per 100 000 people in the SEA domain would increase by 30 from BY2007 while under RED2030 the premature deaths would be cut down (avoided) by 63 from RED2030. In 2007, the maximum annual average BC DRF in the SEA countries was 0.98 W m−2, which would increase to 2.0 W m−2 under BAU2030 and 1.4 W m−2 under RED2030. Substantial impacts on human health and BC DRF reduction in SEA could result from the emission measures incorporated in RED2030. Future works should consider other impacts, such as for agricultural crop production, and the cost–benefit analysis of the measures' implementation to provide relevant information for policy making.

Provincial touring companies of the late Victorian period, comprising mostly unknown actors and actresses, have received minimal scholarly attention until recently. The sheer number of ‘on-the-road’ artists who were employed in such enterprises from the late nineteenth century onwards increased to such an extent that to establish a framework for their individual and collective study presents significant challenges. This article addresses this problem by proposing a method, grounded in genealogy, that records the male and/or female artists of a given touring company over its full term without selective bias in order to establish a cohort of subjects for further examination. It tracks the touring companies of actor-manager Lawrence Daly, an individual unheard of today, between 1887 and 1900, the year of his death. One hundred and twenty-five female artists employed by Daly during this period are recovered, and their careers, family histories, and personal identities are subjected to statistical analysis. The conclusions drawn here not only contribute to the better understanding of the social history of non-elite female provincial artists of the late nineteenth century, but also afford the opportunity to shine a light on figures whose names, lives, and achievements are long forgotten. Further, a case is made for the method as the basis for a wide-ranging database of provincial touring companies and artists. Bernard Ince is an independent theatre historian who has contributed several articles on Victorian and Edwardian theatre to New Theatre Quarterly.

Introduction (problem statement and relevance). The article presents the work on the automation of an internal combustion engine (ICE) calibration tests results on a motor stand. The relevance of the article is due to the high labor intensity of such tests, the complexity of documentation and decisionmaking based on the results of the work.Purpose of the study. This work is part of a comprehensive methodology, the purpose of which is to reduce the duration of tests and improve the calibration results quality of the vehicle’s power plant. The entire methodology description as a whole is also given in the publication.Methodology and research methods. The achievement of this goal is ensured with the help of special systems – INCA-FLOW (test automation) and ASCMO (processing results and optimization), produced by Bosch/ETAS. The approbation of the technique was carried out on a motor stand in the MADI training box in relation to the problem of forming an ignition timing map.Scientific novelty and results. As a result of the methodology application, a 4.8 times reduction in the motor tests duration takes place if 2 people work in manual mode at the test bench without interruption.At the same time, the variance of the adequacy of Sad of the torque empirical model Mk turned out to be, on average, 1.5 times less if the model was built according to the automated tests results. The obtained data indicated an improvement in the quality of measurements in the transition to automated test methods.From a scientific point of view, the most original part of the work is the application of the “Gaussian process” method to build empirical models. This method provides more accurate results than, for example, the traditional method of least squares.The practical significance of the work lies in the ability to considerably reduce routine actions on a motor stand, and the additional time spent on developing and testing a test scenario (program) is compensated for by the fact that scenario models can be used in the future for other similar tests. The proposed methodology makes it possible to cover a significant part of the internal combustion engine calibration tests. For example, you can apply it if you possess the preliminary information about the test object (basing on which you can draw up an experiment plan) and the engine is to be prepared either for a car road tests or tests under special conditions.

This article uses census data and village histories to examine changes over the last 35 years in the four villages where the Institute of Nutrition of Central America and Panama (INCAP) Longitudinal Study (1969–77) was conducted and offers a rare picture of development and change in rural localities over a long period of time. In addition, by characterizing the environment in which the subjects of this study were raised, we provide context for and inputs into quantitative analyses of data collected at various points in time on these subjects. The villages have undergone massive demographic, social, and economic change. Initial differences have conditioned many of these changes, especially differences associated with agricultural potential and location. Originally these villages were rather isolated, but road and transportation access has improved substantially. The populations in the villages have more than doubled and also have aged. While marriage patterns have held steady, religious practice has changed a great deal. After many years of steady out-migration, three of the four villages are more recently experiencing net in-migration, a pattern associated with ease of access. Schooling access and outcomes also have improved, with average grades of schooling nearly tripling and literacy doubling to levels currently above national averages. Although agriculture remains an important component of individual livelihood strategies, non-agricultural sources of employment have become more important. Much of this change is associated with declining agricultural markets and increased access to non-agricultural jobs near the villages and in the capital. Accompanying these changes has been an improvement in living standards as measured by a number of indicators of household living conditions and consumer durable goods.

Abstract Background: Peripheral neuropathy occurs in 20-25% of patients with an IgM paraprotein and 40-50% of patients with an IgM monoclonal gammopathy have a detectable anti-myelin associated glycoprotein (MAG) antibody. The presence of an anti-MAG antibody is often associated with a chronic, progressive symmetric demyelinating polyneuropathy that can lead to sensory deficits and gait dysfunction, significantly altering a patient’s quality of life. Prior clinical trials have failed to demonstrate an effective long-term therapy for anti-MAG neuropathy. Additionally, the best manner to assess the evolution of this type of neuropathy has not been elucidated. We designed this clinical trial to evaluate a potential therapy for anti-MAG related neuropathy based on previous reports of subjective improvement in patients with anti-MAG neuropathy treated with rituximab or Bruton’s tyrosine kinase inhibitors. We included multiple neurologic outcome measures so their responsiveness and performance could be assessed in a clinical trial setting. Methods: This is a single-arm open-label phase II trial investigating the use of acalabrutinib and an anti-CD20 monoclonal antibody for the treatment of an IgM-associated anti-MAG mediated neuropathy. Eligible patients must have positive anti-MAG antibody titers with an IgM monoclonal gammopathy of undetermined significance (MGUS) or Waldenström macroglobulinemia (WM). Patients must have a predominantly sensory neuropathy characterized by demyelinating features in nerve conduction studies with a modified Rankin score of ≥1 with progressive symptoms or a modified Rankin score of ≥2. The ECOG performance status must be ≤2. Acceptable organ and marrow function are required. Prior exposure to chemotherapy, Bruton Tyrosine Kinase inhibitors, or other therapies for WM are not permitted except for steroids, IVIg, or an anti-CD20 monoclonal antibody given at least 90 days before study drug initiation. Approximately 33 patients will be enrolled in this study. Patients will be treated with acalabrutinib 100 mg orally twice daily on days 1-28 of each cycle and treatment will be administered until disease progression or unacceptable toxicity. Rituximab (or a biosimilar) will be administered on days 1, 8, 15, and 22 of cycles 1 and 4. The primary endpoint of this trial is to evaluate the overall hematologic response rate (defined as ≥25% reduction in serum IgM) associated with the treatment. The key secondary endpoint is to evaluate the proportion of patients that achieve improvement or stability in neuropathic symptoms based on the Inflammatory Rasch-built Overall Disability Scale (I-RODS) patient-reported disability scale. Additional secondary neurologic endpoints include the INCAT disability score, exam-based outcomes (the MRC distal sum score and INCAT-ISS), measures of function (10-meter walk test, 9-hole peg test), a pain scale, a fatigue scale (FSS), and a neuropathy-specific quality of life scale (IN-QOL). Additional secondary endpoints include time to next treatment, overall survival, hematologic response based on MYD88 and CXCR4 mutational status, change in bone marrow disease burden, and proportion of adverse events associated with treatment. This study is currently open and accruing patients. Clinical trial information: NCT05065554 Sponsor: AstraZeneca Citation Format: Shayna Sarosiek, Christopher T. Doughty, Andrew Branagan, Catherine A. Flynn, Kirsten Meid, Timothy P. White, Megan Little, Carly Leventoff, Steven P. Treon, Jorge J. Castillo. Phase II study of acalabrutinib and an anti-CD20 monoclonal antibody in patients with anti-MAG mediated neuropathy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT550.

The Andes offers a particularly effective focus for an archaeology of mobility because their extreme topography compresses enormous vertical resource diversity across short horizontal distances. In this article, the authors combine findings from two large-scale archaeological studies of adjacent watersheds—the Nasca-Palpa Project and One River Project—to provide the necessary context in which to explore changing mobilities from the Archaic Period to the Inca Empire, and from the Pacific coast to the high Andes. Analyses of obsidian lithics and stable isotopes in human hair are used to argue that changing patterns of mobility offer a new way of defining the ‘Horizons’ that have long dominated concepts of periodisation here.