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Journal articles on the topic 'Including nanoparticle-based systems'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Vines, Jeremy, Dong-Jin Lim, and Hansoo Park. "Contemporary Polymer-Based Nanoparticle Systems for Photothermal Therapy." Polymers 10, no. 12 (2018): 1357. http://dx.doi.org/10.3390/polym10121357.

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Current approaches for the treatment of cancer, such as chemotherapy, radiotherapy, immunotherapy, and surgery, are limited by various factors, such as inadvertent necrosis of healthy cells, immunological destruction, or secondary cancer development. Hyperthermic therapy is a promising strategy intended to mitigate many of the shortcomings associated with traditional therapeutic approaches. However, to utilize this approach effectively, it must be targeted to specific tumor sites to prevent adverse side effects. In this regard, photothermal therapy, using intravenously-administered nanoparticl

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Maurya, Aarati, and Shivam Tyagi. "Recent Advances in Nanoparticle-Based Drug Delivery Systems." Journal of Drug Discovery and Health Sciences 1, no. 04 (2024): 201–11. https://doi.org/10.21590/jddhs.01.04.03.

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Nanoparticle-based drug delivery systems (NDDS) have emerged as a revolutionary approach in pharmaceutical development, offering significant improvements in drug bioavailability, therapeutic efficacy, and patient compliance. This review provides an overview of recent advances in nanoparticle-based drug delivery systems, focusing on novel nanoparticle formulations, surface modifications for targeted drug delivery, and the mechanisms of controlled release. The article explores various types of nanoparticles, including polymeric nanoparticles, liposomes, lipid nanoparticles, dendrimers, nanogels,

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Gupta, Purnima, Evelyn Garcia, Amrita Sarkar, et al. "Nanoparticle Based Treatment for Cardiovascular Diseases." Cardiovascular & Hematological Disorders-Drug Targets 19, no. 1 (2019): 33–44. http://dx.doi.org/10.2174/1871529x18666180508113253.

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Nanotechnology has gained increased attention for delivering therapeutic agents effectively to the cardiovascular system. Heart targeted nanocarrier based drug delivery is a new, effective and efficacious approach for treating various cardiac related disorders such as atherosclerosis, hypertension, and myocardial infarction. Nanocarrier based drug delivery system circumvents the problems associated with conventional drug delivery systems, including their nonspecificity, severe side effects and damage to the normal cells. Modification of physicochemical properties of nanocarriers such as size,

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Islam, Mohammad Ariful, Emma K. G. Reesor, Yingjie Xu, Harshal R. Zope, Bruce R. Zetter, and Jinjun Shi. "Biomaterials for mRNA delivery." Biomaterials Science 3, no. 12 (2015): 1519–33. http://dx.doi.org/10.1039/c5bm00198f.

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Schematic representation of various biomaterial-based systems for mRNA delivery: (a) protamine–mRNA complex; (b) lipid nanoparticle; (c) lipid nanoparticle with inorganic compounds (e.g.apatite); (d) cationic polymeric nanoparticle; (e) lipid–polymer hybrid nanoparticles including (i) mRNA–polymer complex core surrounded by a lipid shell and (ii) polymer core surrounded by a lipid shell with mRNA absorbed onto the surface; and (f) gold nanoparticle.

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Filipić, Brankica, Ivana Pantelić, Ines Nikolić, et al. "Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines." Vaccines 11, no. 7 (2023): 1172. http://dx.doi.org/10.3390/vaccines11071172.

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Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms that induce a broader immune response compared to traditional vaccines. Modern vaccines tend to rely on certain nanotechnology platforms but are still expected to be readily available and easy for large-scale manufacturing and to induce a durable immune response. In this review, we present an overvie

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Dukare, Sagar* Kale Gaurav Datkhile Sachin Lokhande Rahul Chavan Rutuja. "Role of Herbal Drug Delivery Systems in Chronic Disease Management." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2242–53. https://doi.org/10.5281/zenodo.15239206.

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Chronic diseases, such as diabetes, cardiovascular disorders, and arthritis, pose significant health challenges worldwide, necessitating effective management strategies. Herbal medicines have gained prominence due to their therapeutic potential and historical use in traditional medicine. However, the efficacy of herbal treatments is often limited by issues related to bioavailability, stability, and patient compliance. This review explores the role of advanced herbal drug delivery systems in enhancing the therapeutic outcomes of herbal medicines in chronic disease management. We discuss various

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Pandey, Ramendra Pati, Jasmina Vidic, Riya Mukherjee, and Chung-Ming Chang. "Experimental Methods for the Biological Evaluation of Nanoparticle-Based Drug Delivery Risks." Pharmaceutics 15, no. 2 (2023): 612. http://dx.doi.org/10.3390/pharmaceutics15020612.

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Many novel medical therapies use nanoparticle-based drug delivery systems, including nanomaterials through drug delivery systems, diagnostics, or physiologically active medicinal products. The approval of nanoparticles with advanced therapeutic and diagnostic potentials for applications in medication and immunization depends strongly on their synthesizing procedure, efficiency of functionalization, and biological safety and biocompatibility. Nanoparticle biodistribution, absorption, bioavailability, passage across biological barriers, and biodistribution are frequently assessed using bespoke a

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Mainini, Francesco, and Michael R. Eccles. "Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy." Molecules 25, no. 11 (2020): 2692. http://dx.doi.org/10.3390/molecules25112692.

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RNA interference (RNAi) uses small interfering RNAs (siRNAs) to mediate gene-silencing in cells and represents an emerging strategy for cancer therapy. Successful RNAi-mediated gene silencing requires overcoming multiple physiological barriers to achieve efficient delivery of siRNAs into cells in vivo, including into tumor and/or host cells in the tumor micro-environment (TME). Consequently, lipid and polymer-based nanoparticle siRNA delivery systems have been developed to surmount these physiological barriers. In this article, we review the strategies that have been developed to facilitate si

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Tasawar Abbas, Fatima Kanwar, Hazima Tariq, and Muhammad Raza Malik. "Nanoparticles in Drug Delivery Systems: Challenges, Innovations, And Surface Modification for Targeted Therapeutics." Indus Journal of Bioscience Research 3, no. 1 (2025): 325–36. https://doi.org/10.70749/ijbr.v3i1.507.

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Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement in bioavailability, stability, and controlled delivery of therapeutic agents. Here, we discuss the broad spectrum of potential in nanoparticle-based drug delivery systems. Challenges, innovations, and the surface modification strategies that affect their clinical translation are discussed. Notwithstanding the potential they present, challenges including biocompatibility, toxicity, stability, and targeting efficiency persist in restricting

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Page, Katharine, Taylor C. Hood, Thomas Proffen, and Reinhard B. Neder. "Building and refining complete nanoparticle structures with total scattering data." Journal of Applied Crystallography 44, no. 2 (2011): 327–36. http://dx.doi.org/10.1107/s0021889811001968.

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High-energy X-ray and spallation neutron total scattering data provide information about each pair of atoms in a nanoparticle sample, allowing for quantitative whole-particle structural modeling based on pair distribution function analysis. The realization of this capability has been hindered by a lack of versatile tools for describing complex finite structures. Here, the implementation of whole-particle refinement for complete nanoparticle systems is described within two programs,DISCUSandDIFFEV, and the diverse capabilities they present are demonstrated. The build-up of internal atomic struc

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Munyayi, Tozivepi Aaron, and Anine Crous. "Advancing Cancer Drug Delivery with Nanoparticles: Challenges and Prospects in Mathematical Modeling for In Vivo and In Vitro Systems." Cancers 17, no. 2 (2025): 198. https://doi.org/10.3390/cancers17020198.

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Mathematical models are crucial for predicting the behavior of drug conjugate nanoparticles and optimizing drug delivery systems in cancer therapy. These models simulate interactions among nanoparticle properties, tumor characteristics, and physiological conditions, including drug resistance and targeting specificity. However, they often rely on assumptions that may not accurately reflect in vivo conditions. In vitro studies, while useful, may not fully capture the complexities of the in vivo environment, leading to an overestimation of nanoparticle-based therapy effectiveness. Advancements in

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Thongpon, Phonpilas, Menghuan Tang, and Zhaoqing Cong. "Peptide-Based Nanoparticle for Tumor Therapy." Biomedicines 13, no. 6 (2025): 1415. https://doi.org/10.3390/biomedicines13061415.

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Cancer treatment continues to face significant challenges due to the limitations of conventional therapies, including non-specific toxicity, poor bioavailability, and drug resistance. Nanotechnology, particularly peptide-based nanoparticles (NPs), is increasingly recognized as a valuable strategy to address these obstacles. Peptides provide a versatile platform offering high biocompatibility, specificity, biodegradability, and minimal immunogenicity, making them ideal for targeted cancer therapies. This review comprehensively examines recent advancements in peptide-based nanoparticle systems,

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Li, Fei, Yahong Wang, Dandan Chen, and Yunjie Du. "Nanoparticle-Based Immunotherapy for Reversing T-Cell Exhaustion." International Journal of Molecular Sciences 25, no. 3 (2024): 1396. http://dx.doi.org/10.3390/ijms25031396.

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T-cell exhaustion refers to a state of T-cell dysfunction commonly observed in chronic infections and cancer. Immune checkpoint molecules blockading using PD-1 and TIM-3 antibodies have shown promising results in reversing exhaustion, but this approach has several limitations. The treatment of T-cell exhaustion is still facing great challenges, making it imperative to explore new therapeutic strategies. With the development of nanotechnology, nanoparticles have successfully been applied as drug carriers and delivery systems in the treatment of cancer and infectious diseases. Furthermore, nanop

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Thomas, Nurain, Lisa Efriani Puluhulawa, Faradila Ratu Cindana Mo’o, Agus Rusdin, Amirah Mohd Gazzali, and Arif Budiman. "Potential of Pullulan-Based Polymeric Nanoparticles for Improving Drug Physicochemical Properties and Effectiveness." Polymers 16, no. 15 (2024): 2151. http://dx.doi.org/10.3390/polym16152151.

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Pullulan, a natural polysaccharide with unique biocompatibility and biodegradability, has gained prominence in nanomedicine. Its application in nanoparticle drug delivery systems showcases its potential for precision medicine. Aim of Study: This scientific review aims to comprehensively discuss and summarize recent advancements in pullulan-based polymeric nanoparticles, focusing on their formulation, characterization, evaluation, and efficacy. Methodology: A search on Scopus, PubMed, and Google Scholar, using “Pullulan and Nanoparticle” as keywords, identified relevant articles in recent years

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Babu, Anish, Amanda K. Templeton, Anupama Munshi, and Rajagopal Ramesh. "Nanoparticle-Based Drug Delivery for Therapy of Lung Cancer: Progress and Challenges." Journal of Nanomaterials 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/863951.

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The last decade has witnessed enormous advances in the development and application of nanotechnology in cancer detection, diagnosis, and therapy culminating in the development of the nascent field of “cancer nanomedicine.” A nanoparticle as per the National Institutes of Health (NIH) guidelines is any material that is used in the formulation of a drug resulting in a final product smaller than 1 micron in size. Nanoparticle-based therapeutic systems have gained immense popularity due to their ability to overcome biological barriers, effectively deliver hydrophobic therapies, and preferentially

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Çolak, Ceren. "Nanoparticle-Based Drug Delivery Systems and Targeting Strategies in Breast Cancer Therapy." Haliç Üniversitesi Fen Bilimleri Dergisi 8, no. 1 (2025): 81–101. https://doi.org/10.46373/hafebid.1652048.

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Breast cancer continues to be a major contributor to cancer-related mortality globally, highliting the critical importance of developing more efficient and safer therapy strategies. Nanoparticle-based drug delivery systems offer a promising approach by enhancing drug accumulation in tumor tissues while minimizing systemic toxicity. This article explores the unique properties and advantages of various nanoparticles, including liposomal, polymer-, carbon- and mesoporous silica nanoparticles, in breast cancer therapy. Additionally, it delves into three key targeting mechanisms: passive targeting

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Tanu, Shri Biswas*. "Impact of Nanoparticle Size and Concentration on the Release Profile and Pharmacokinetics of Proton Pump Inhibitors (PPIS): A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2809–15. https://doi.org/10.5281/zenodo.15448392.

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Proton pump inhibitors (PPIs) are widely prescribe00000d for the treatment of acid-related gastrointestinal disorders, yet their clinical efficacy is often limited by poor solubility, acid-lability, and short systemic half-life. Nanoparticle-based drug delivery systems have emerged as a promising approach to overcome these limitations by enhancing drug stability, improving bioavailability, and enabling controlled release. Among the critical formulation parameters, nanoparticle size and concentration play pivotal roles in dictating the release profile, absorption kinetics, and overall pharmacok

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Nie, Yuhan, Guo Fu, and Yuxin Leng. "Nuclear Delivery of Nanoparticle-Based Drug Delivery Systems by Nuclear Localization Signals." Cells 12, no. 12 (2023): 1637. http://dx.doi.org/10.3390/cells12121637.

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Nanomedicine 2.0 refers to the next generation of nanotechnology-based medical therapies and diagnostic tools. This field focuses on the development of more sophisticated and precise nanoparticles (NPs) for targeted drug delivery, imaging, and sensing. It has been established that the nuclear delivery of NP-loaded drugs can increase their therapeutic efficacy. To effectively direct the NPs to the nucleus, the attachment of nuclear localization signals (NLSs) to NPs has been employed in many applications. In this review, we will provide an overview of the structure of nuclear pore complexes (NP

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Gangisetty, Gopalakrishna, and Ron Zevenhoven. "A Review of Nanoparticle Material Coatings in Passive Radiative Cooling Systems Including Skylights." Energies 16, no. 4 (2023): 1975. http://dx.doi.org/10.3390/en16041975.

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Daytime passive radiative cooling (DPRC) has remained a challenge over the past decades due to the necessity of precisely defined materials with a significantly high emissivity of thermal radiation within the atmospheric transparent window wavelength range (8–13 μm) as well as high reflectivity in the solar spectrum (0.2–3 μm). Fortunately, recent advances and technological improvements in nanoscience and metamaterials are making it possible to create diverse metamaterials. This enables the production of DPRC in direct solar irradiation. The development of a material that is appropriate for ef

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Anil Kishore, Banubadi, Amrutha Desai, Swastika Tiwari, and Vettrivel Arul. "Advances in Nanoparticle-Based Drug Delivery Systems: Enhancing Targeted Therapeutic Efficacy in Pharmaceutical Science and Technologycrete Technology." Journal of Neonatal Surgery 14, no. 2 (2025): 59–68. https://doi.org/10.52783/jns.v14.1717.

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Nanoparticle-based drug delivery systems have revolutionized the pharmaceutical landscape, offering groundbreaking solutions to longstanding challenges in drug development and therapeutic applications. These advanced systems harness the unique properties of nanoparticles—such as their size, surface functionality, and ability to encapsulate therapeutic agents—to enhance the efficacy and precision of treatments. This study explores recent advances in nanoparticle-based drug delivery systems, emphasizing their role in improving targeted therapeutic efficacy. The research delves into key developme

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Sung, Hyo-Dong, Nayeon Kim, Yeram Lee, and Eun Jung Lee. "Protein-Based Nanoparticle Vaccines for SARS-CoV-2." International Journal of Molecular Sciences 22, no. 24 (2021): 13445. http://dx.doi.org/10.3390/ijms222413445.

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The pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has upended healthcare systems and economies around the world. Rapid understanding of the structural biology and pathogenesis of SARS-CoV-2 has allowed the development of emergency use or FDA-approved vaccines and various candidate vaccines. Among the recently developed SARS-CoV-2 candidate vaccines, natural protein-based nanoparticles well suited for multivalent antigen presentation and enhanced immune stimulation to elicit potent humoral and cellular immune responses are currently being investigated. This

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Rakhi, Rani, Kumar Sudhir, and Kumar Sinha Keshav. "The Development of Novel Drug Delivery Systems for Improved Therapeutic Efficacy: A Retrospective Study." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 643–48. https://doi.org/10.5281/zenodo.11192437.

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<strong>Background:</strong> Novel drug delivery systems have sparked interest in pursuing better therapeutic efficacy in pharmacology. This retrospective study compared the effectiveness of liposomal formulations, systems based on nanoparticles, and conventional distribution methods, which included 200 participants. <strong>Methods:</strong> Treatment outcomes, safety profiles, and treatment durations were evaluated by thoroughly examining electronic medical information. All three medication distribution methods were compared using statistical tools, including logistic regressi

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Torres, Judith, Tatiana Lara, and Marcelo Grijalva. "Nanoparticle applications in intracellular infections." Journal of Drug Delivery and Therapeutics 12, no. 5-S (2022): 217–19. http://dx.doi.org/10.22270/jddt.v12i5-s.5738.

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Objective: To review selected recent studies on the therapeutic applications of nanoparticles and nanoparticle-conjugated antimicrobials as new therapeutic alternatives for a variety of intracellular infections. Data Sources: Recent published papers on nanoparticles and intracellular infections, including bacterial, viral, and parasitic diseases in humans. The PubMed database was used as the main source. Publicly available papers were retrieved. Summary of Contents: Therapeutic failure in intracellular infections is a challenging clinical problem. Antibiotics, anti-parasitics, anti

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Ogba, Chukwuemeka Emmanuel, Akpabio Elijah Akwaowoh, Ifeoluwa Adetomiwa Taiwo, Precious Joshua Edem, and Sunday Olajide Awofisayo. "Optimizing levofloxacin delivery using nanoparticles: a strategy for improved bioavailability and targeted release." Journal of Drug Delivery and Therapeutics 15, no. 5 (2025): 42–49. https://doi.org/10.22270/jddt.v15i5.7119.

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Nanoparticle-based drug delivery systems have emerged as a powerful strategy to enhance drug bioavailability and ensure targeted therapeutic release. Levofloxacin (LFX), a widely used broad-spectrum fluoroquinolone antibiotic, is limited by poor aqueous solubility, low oral bioavailability, and systemic side effects. This study investigates the formulation, characterization, and evaluation of levofloxacin-loaded nanoparticles aimed at improving its pharmacological performance. Various nanoparticle carriers, including polymeric nanoparticles, lipid-based nanocarriers, and inorganic nanoparticle

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Koo, Sangmo. "Flexible Heater Fabrication Using Amino Acid-Based Ink and Laser-Direct Writing." Micromachines 13, no. 12 (2022): 2209. http://dx.doi.org/10.3390/mi13122209.

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Nature’s systems have evolved over a long period to operate efficiently, and this provides hints for metal nanoparticle synthesis, including the enhancement, efficient generation, and transport of electrons toward metal ions for nanoparticle synthesis. The organic material-based ink composed of the natural materials used in this study requires low laser power for sintering compared to conventional nanoparticle ink sintering. This suggests applicability in various and sophisticated pattern fabrication applications without incurring substrate damage. An efficient electron transfer mechanism betw

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Zade, Alka, and Dr Aarti Shastri. "Nanoparticle-Based Drug Delivery: Enhancing Bioavailability and Therapeutic Efficacy in Pharmaceutical Applications." Journal of Internal Medicine and Pharmacology (JIMP) 1, no. 03 (2024): 26–38. https://doi.org/10.61920/jimp.v1i03.32.

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Nanoparticle-based drug delivery systems have emerged as a transformative approach to enhance drug bioavailability and therapeutic efficacy in various pharmaceutical applications. These systems exploit the unique properties of nanoparticles, including high surface-to-volume ratios, targeted delivery capabilities, and controlled release profiles, to optimize drug administration. This review explores the types of nanoparticles utilized in drug delivery, such as polymeric nanoparticles, liposomes, dendrimers, and metallic nanoparticles, with an emphasis on their role in enhancing drug bioavailabi

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Awais Ibrahim, Sehar ul Islam, Rabeea Razaq, et al. "Use of Nanoparticles in Pharmaceutical and Drug Delivery Systems: Advances and Challenges." Indus Journal of Bioscience Research 3, no. 1 (2024): 815–26. https://doi.org/10.70749/ijbr.v3i1.611.

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Nanoparticles represent a significant innovation in pharmaceutical drug delivery, tackling essential issues such as inadequate solubility, restricted bioavailability, and systemic toxicity of medicinal medicines. Their distinctive physicochemical characteristics, such as nanoscale dimensions, elevated surface area-to-volume ratio, and adjustable surface functions, provide accurate targeting and regulated drug release, rendering them essential for contemporary medicine. This review synthesizes contemporary advances, obstacles, and emerging trends in nanoparticle-mediated drug delivery methods.

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Poudel, Prashant, and Soyeun Park. "Recent Advances in the Treatment of Alzheimer’s Disease Using Nanoparticle-Based Drug Delivery Systems." Pharmaceutics 14, no. 4 (2022): 835. http://dx.doi.org/10.3390/pharmaceutics14040835.

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Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder. Most existing treatments only provide symptomatic solutions. Here, we introduce currently available commercial drugs and new therapeutics, including repositioned drugs, to treat AD. Despite tremendous efforts, treatments targeting the hallmarks of AD show limited efficacy. Challenges in treating AD are partly caused by difficulties in penetrating the blood–brain barrier (BBB). Recently, nanoparticle (NP)-based systems have shown promising potential as precision medicines that can effectively penetrate the B

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Kherde, Gauravi Sunilrao, Rahul Dnyaneshwar Khaire, Vikas Dhamu Kunde, Pooja Gajanan Akoshkar, Pratiksha Suresh katkade, and Komal Sunil Taru. "Recent Advances in Mesoporous Silica Nanoparticle-Based Topical Delivery Systems: A Systematic Review." Biosciences Biotechnology Research Asia 22, no. 2 (2025): 521–34. https://doi.org/10.13005/bbra/3380.

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ABSTRACT: The perfect properties of mesoporous silica nanoparticles (MSNs), such as their wide surface area, large pore size, and biocompatibility, have attracted good consumers for topical medicinal goods in recent years. This systematic review focus to impart an in-depth outline of recent developments in MSN-based cosmetics and highlight their potential in dermatological and cosmetic applications. mesoporous silica nanoparticles provide a multiple platform for the encapsulation and prolonged release of numerous medical compounds, including anti-inflammatory and developmental drugs, thereby i

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Anant, Prakash Pandey, and Kumar Shukla Santosh. "Polyphenol based novel drug delivery carriers for the treatment of ageing related neurodegenerative disorder: a modern approach." International Journal of Advances in Pharmacy Medicine and Bioallied Sciences 10, no. 2 (2022): 76–81. https://doi.org/10.5281/zenodo.7046004.

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The main risk factor for the emergence and spread of neurodegenerative disorders (ND) is age. The growth in ND prevalence, particularly in emerging nations, is thought to be mostly caused by the expansion of longevity. The challenge for doctors and researchers is to find treatment approaches able to slow down neurodegeneration and/or improve the patient's quality of life because there is currently no cure for any of them. Increased cellular oxidative stress has been identified as one of the potential risk factors in ND, along with genetics and environmental stresses. The antioxidant effect

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Dhanabalan, Dharanidharan, and Narkunaraja Shanmugam. "Nanomedicine in cancer treatment - an overview." Advances in Natural Sciences: Nanoscience and Nanotechnology 16, no. 1 (2024): 013001. https://doi.org/10.1088/2043-6262/ad9f49.

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Abstract Cancer remains a formidable global health challenge, with millions of lives lost annually and a projected increase in cases, particularly in regions like South Central Asia, Europe, Eastern Europe, etc, Traditional cancer treatments, including chemotherapy, radiotherapy, and surgery, face limitations in effectively managing the complex tumor microenvironment and addressing the diverse characteristics of cancer cells. Nano-oncology has emerged as a promising frontier in cancer therapy, utilizing nanoscale materials to deliver therapeutic agents with precision and efficacy. The benefits

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Kim, Minse, Youngwoo Hwang, Seongyu Lim, Hyeon-Ki Jang, and Hyun-Ouk Kim. "Advances in Nanoparticles as Non-Viral Vectors for Efficient Delivery of CRISPR/Cas9." Pharmaceutics 16, no. 9 (2024): 1197. http://dx.doi.org/10.3390/pharmaceutics16091197.

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The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system is a gene-editing technology. Nanoparticle delivery systems have attracted attention because of the limitations of conventional viral vectors. In this review, we assess the efficiency of various nanoparticles, including lipid-based, polymer-based, inorganic, and extracellular vesicle-based systems, as non-viral vectors for CRISPR/Cas9 delivery. We discuss their advantages, limitations, and current challenges. By summarizing recent advancements and highlighting key strategies, this review aims to provide a compreh

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Mushtaq, Sadia. "Nanoparticle-Mediated Delivery of Viperin: Advancing Therapy Across Diverse Viral Infections." TSF Journal of Biology 2, no. 1 (2024): 1–16. http://dx.doi.org/10.69547/tsfjb.020101.

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Nanotechnology-based delivery systems hold immense potential to revolutionize antiviral therapy by providing efficient mechanisms of gene delivery systems. Nanoparticles, with their specific characteristics and various properties, offer intriguing potential for improving the efficacy and specificity of antiviral therapies. Viral infection in a host cell triggers a range of host immune responses to prevent viral invasion through the activity of different antiviral proteins. Among these proteins, viperin plays a crucial role in the host's innate immune response against a broad range of viral dis

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Rajashree, G. Jagtap Mrunal S. Pagare. "Novel Functionalised Polymer Based Nanoparticle Formulation With Anti Cancer Drug." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 2452–69. https://doi.org/10.5281/zenodo.13173238.

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A tailored and customised medication delivery method was developed to address the drawbacks of traditional dosage forms. At this time, there was a great desire for innovative medication delivery systems. One kind of targeted medicine delivery technique is nanoparticles. Colloidal particles called nanoparticles allow medications to be delivered to specified locations. While there are many distinct types of nanoparticles, polymeric nanoparticles are unique. One of the topics being researched the most right now is polymer nanoparticles. Polymer-based nanoparticles include dendrimers, ligand-based

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Shukurat Opeyemi Rahmon, Mariam Allison, and Emmanuel Ayodeji Osoko. "Bayesian fractional stochastic models for controlled release mechanisms in nanoparticle drug delivery." World Journal of Advanced Engineering Technology and Sciences 8, no. 1 (2023): 459–68. https://doi.org/10.30574/wjaets.2023.8.1.0058.

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Optimizing drug release kinetics from nanocarriers is crucial for enhancing therapeutic efficacy and minimizing systemic toxicity in pharmaceutical formulations. Traditional deterministic models often fail to adequately capture the complex, non-Fickian diffusion and stochastic variability inherent in nanoparticle-based drug delivery systems. This study develops and applies a Bayesian fractional stochastic model to describe drug release kinetics from liposomal, polymeric, and metallic nanoparticles. The model integrates fractional calculus to account for anomalous diffusion and memory effects,

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Kim, Dong-Kee. "Recent Advances in Functionalized Nanoparticles for Targeted and Controlled Inner Ear Therapy via Localized Cochlear Delivery." Journal of Audiology and Otology 29, no. 3 (2025): 159–65. https://doi.org/10.7874/jao.2025.00311.

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Treatment of sensorineural hearing loss (SNHL) is challenging due to the inner ear’s complex anatomy and physiological barriers, such as the blood–labyrinth barrier. Nanoparticle-based drug delivery systems have emerged as promising solutions, offering targeted, sustained, and stimuli-responsive therapeutic options. This review discusses recent advancements in nanoparticle functionalization strategies for inner ear drug delivery. Active targeting approaches, such as the use of prestin-specific peptides, enable selective delivery to outer hair cells. Stimuli-responsive systems, including thermo

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Domingues, Joana M., Catarina S. Miranda, Natália C. Homem, Helena P. Felgueiras, and Joana C. Antunes. "Nanoparticle Synthesis and Their Integration into Polymer-Based Fibers for Biomedical Applications." Biomedicines 11, no. 7 (2023): 1862. http://dx.doi.org/10.3390/biomedicines11071862.

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The potential of nanoparticles as effective drug delivery systems combined with the versatility of fibers has led to the development of new and improved strategies to help in the diagnosis and treatment of diseases. Nanoparticles have extraordinary characteristics that are helpful in several applications, including wound dressings, microbial balance approaches, tissue regeneration, and cancer treatment. Owing to their large surface area, tailor-ability, and persistent diameter, fibers are also used for wound dressings, tissue engineering, controlled drug delivery, and protective clothing. The

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Kim, Jin, Myeong Moon, Dong Kim, Suk Heo, and Yong Jeong. "Hyaluronic Acid-Based Nanomaterials for Cancer Therapy." Polymers 10, no. 10 (2018): 1133. http://dx.doi.org/10.3390/polym10101133.

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Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan and a major component of the extracellular matrix. HA is overexpressed by numerous tumor cells, especially tumor-initiating cells. HA-based nanomaterials play in importance role in drug delivery systems. HA is used in various types of nanomaterials including micelle, polymersome, hydrogel, and inorganic nanoparticle formulations. Many experiments show that HA-based nanomaterials can serve as a platform for targeted chemotherapy, gene therapy, immunotherapy, and combination therapy with good potential for future biomedical applications in

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Wu, Peijie, Jun Han, Yanju Gong, Chao Liu, Han Yu, and Na Xie. "Nanoparticle-Based Drug Delivery Systems Targeting Tumor Microenvironment for Cancer Immunotherapy Resistance: Current Advances and Applications." Pharmaceutics 14, no. 10 (2022): 1990. http://dx.doi.org/10.3390/pharmaceutics14101990.

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Cancer immunotherapy has shown impressive anti-tumor activity in patients with advanced and early-stage malignant tumors, thus improving long-term survival. However, current cancer immunotherapy is limited by barriers such as low tumor specificity, poor response rate, and systemic toxicities, which result in the development of primary, adaptive, or acquired resistance. Immunotherapy resistance has complex mechanisms that depend on the interaction between tumor cells and the tumor microenvironment (TME). Therefore, targeting TME has recently received attention as a feasibility strategy for re-s

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Gorohovs, Marks, and Yuri Dekhtyar. "Surface Functionalization of Nanoparticles for Enhanced Electrostatic Adsorption of Biomolecules." Molecules 30, no. 15 (2025): 3206. https://doi.org/10.3390/molecules30153206.

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Electrostatic adsorption plays a crucial role in nanoparticle-based drug delivery, enabling the targeted and reversible loading of biomolecules onto nanoparticles. This review explores the fundamental mechanisms governing nanoparticle–biomolecule interactions, with a focus on electrostatics, van der Waals forces, hydrogen bonding, and protein corona formation. Various functionalization strategies—including covalent modification, polymer coatings, and layer-by-layer assembly—have been employed to enhance electrostatic binding; however, each presents trade-offs in terms of stability, complexity,

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A., Awasare, and Mulani S. "A Study on Nanoparticles as Additives in Engineering Applications." Research and Reviews: Journal of Mechanical Engineering 1, no. 1 (2025): 18–22. https://doi.org/10.5281/zenodo.15229625.

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<em>Nanoparticles have emerged as promising additives in various engineering applications, offering significant improvements in lubrication, thermal conductivity, wear resistance, and mechanical properties. This study explores the role of nanoparticles as performance-enhancing additives in lubricants, coatings, and composite materials. A comprehensive analysis of different nanoparticle types, including metal oxides, carbon-based nanomaterials, and ceramic nanoparticles, is conducted to evaluate their impact on friction reduction, heat dissipation, and durability. Experimental and computational

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Vong, Long Binh, and Yukio Nagasaki. "Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges." Antioxidants 9, no. 9 (2020): 791. http://dx.doi.org/10.3390/antiox9090791.

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Nitric oxide (NO) plays important roles in various physiological and pathological functions and processes in the human body. Therapeutic application of NO molecules has been investigated in various diseases, including cardiovascular disease, cancer, and infections. However, the extremely short half-life of NO, which limits its clinical use considerably, along with non-specific distribution, has resulted in a low therapeutic index and undesired adverse effects. To overcome the drawbacks of using this gaseous signaling molecule, researchers in the last several decades have focused on innovative

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Sarrafzadeh Javadi, Farhood, and Rahman Saidur. "Thermodynamic and Energy Efficiency Analysis of a Domestic Refrigerator Using Al2O3 Nano-Refrigerant." Sustainability 13, no. 10 (2021): 5659. http://dx.doi.org/10.3390/su13105659.

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Refrigeration systems have experienced massive technological changes in the past 50 years. Nanotechnology can lead to a promising technological leap in the refrigeration industry. Nano-refrigerant still remains unknown because of the complexity of the phase change process of the mixture including refrigerant, lubricant, and nanoparticle. In this study, the stability of Al2O3 nanofluid and the performance of a nano-refrigerant-based domestic refrigerator have been experimentally investigated, with the focus on the thermodynamic and energy approaches. It was found that by increasing the nanopart

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Ali, Muhammad, Viviana Benfante, Domenico Di Raimondo, Giuseppe Salvaggio, Antonino Tuttolomondo, and Albert Comelli. "Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent." Pharmaceuticals 17, no. 1 (2024): 126. http://dx.doi.org/10.3390/ph17010126.

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Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, its anticancer efficacy is impeded by low water solubility, dose-limiting toxicity, low bioavailability, and rapid hepatic metabolism. To overcome these hurdles, various nanoparticles such as organic and inorganic nanoparticles, liposomes, polymeric nanoparticles, dendrimers, solid lipid nanoparticles, gold nanoparticles, zinc oxide nanoparticles, zeolitic imidazolate frameworks, carbon na

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Nasir, Fazli. "The Promise of Exosomes as Drug Delivery Systems." Pharmaceutical Communications 2, no. 1 (2023): 01–02. http://dx.doi.org/10.55627/pharma.002.01.0332.

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Exosomes are small extracellular vesicles that play a role in cell-to-cell communication by transferring bioactive molecules such as proteins, nucleic acids, and lipids between cells. Over the past few years, there have been significant advances in utilizing exosomes as drug delivery systems due to their unique properties, including their ability to target specific cells and tissues. Especially advances in targeted delivery, nanoparticle incorporation, personalized medicine, cargo delivery, imaging, and tracking have excited the pharmaceutical community about their potential use in these areas

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Czaplicka, Natalia, Anna Grzegórska, Jan Wajs, Joanna Sobczak, and Andrzej Rogala. "Promising Nanoparticle-Based Heat Transfer Fluids—Environmental and Techno-Economic Analysis Compared to Conventional Fluids." International Journal of Molecular Sciences 22, no. 17 (2021): 9201. http://dx.doi.org/10.3390/ijms22179201.

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Providing optimal operating conditions is one of the major challenges for effective heating or cooling systems. Moreover, proper adjustment of the heat transfer fluid is also important from the viewpoint of the correct operation, maintenance, and cost efficiency of these systems. Therefore, in this paper, a detailed review of recent work on the subject of conventional and novel heat transfer fluid applications is presented. Particular attention is paid to the novel nanoparticle-based materials used as heat transfer fluids. In-depth comparison of environmental, technical, and economic character

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Gaikwad, Vaishnavi *. Palghadmal Varsharani Thorat Suvarna. "Nanotechnology Meets Targeted Therapy: Engineering Nanoparticles for Enhanced Drug Delivery." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 533–42. https://doi.org/10.5281/zenodo.14281647.

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Nanoparticle-based targeted drug delivery systems have transformed therapeutic strategies by offering precise and controlled drug delivery to specific sites within the body, thereby enhancing treatment efficacy while reducing systemic side effects. Due to their unique properties—such as small size, high surface area, and the ability to be functionalized with targeting ligands—nanoparticles enable both passive and active targeting. Passive targeting utilizes the enhanced permeability and retention (EPR) effect, while active targeting leverages ligand-receptor interactions for precis

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Singh, Chiranjeev, and Prachi Gurudiwan. "Nanoparticle-Based Drug Delivery Systems for Tumor Treatment: Advancing Solutions to Overcome Drug Resistance." Journal of Cancer Research Updates 14 (June 19, 2025): 105–13. https://doi.org/10.30683/1929-2279.2025.14.12.

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The potential of nanoparticles (NPs) as a drug delivery mechanism (DDM) has prompted extensive study and use of nanotechnology in tumor cell (TC) treatment. Compared to conventional medications, NP-based DDM offers greater stability and biocompatibility, enhanced absorption and preservation, and focused accuracy, which are some of its unique advantages. This drug-carrying technology has reached a new level with the use and improvement of composite nanoparticles (NPs), which combine the unique characteristics of multiple NPs. Additionally, NP-based DDMs have demonstrated effectiveness in overco

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Puspadewi, Ririn, Tiana Milanda, Muhaimin Muhaimin, and Anis Yohana Chaerunisaa. "Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy." Pharmaceuticals 18, no. 2 (2025): 209. https://doi.org/10.3390/ph18020209.

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This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was conducted in various databases for articles published in the last 10 years, with strict inclusion and exclusion criteria. Of the 490 articles found, 40 were considered relevant. Acne vulgaris is a common dermatological disorder characterised by inflammation of the sebaceous glands, often resulting in the development of pimples, cysts, and scarring. Conventional treatments, including antibiotics and topic

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Afshar, Mohammadreza, and Alireza Afshar. "Nanomedicine Approaches in Male Infertility Treatment: Targeted Drug Delivery and Sperm Function Enhancement." Journal of Infertility and Reproductive Biology 12, no. 4 (2024): 31–44. https://doi.org/10.18502/jirb.v12i4.17976.

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Male infertility affects a significant portion of the global population, contributing to nearly half of all infertility cases. Common underlying causes include disruptions in spermatogenesis, hormonal imbalances, and genetic anomalies. Traditional treatments, such as hormone therapy, surgical interventions, and assisted reproductive technologies, often exhibit limited efficacy due to their invasive nature, systemic side effects, and high financial costs. This study explores nanomedicine’s potential as a targeted approach to address these limitations, particularly through advanced nanoparticle-

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