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Journal articles on the topic 'Including platelet count'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Ajay, Kumar, Kumar Binay, Kanaujia Binita, and Raza Sahab. "A Retrospective Investigation to Study the Relationship between White Blood Cell Count (WBC), Which is Known Inflammatory Marker and Platelet Count (PLT) and its Parameters." International Journal of Toxicological and Pharmacological Research 13, no. 2 (2023): 76–82. https://doi.org/10.5281/zenodo.11280384.

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<strong>Aim: </strong>The aim of this study was to investigate the relationship between white blood cell count (WBC), which is known inflammatory marker and platelet count (PLT) and its parameters including mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and platelet- large cell ratio (P-LCR) in all clinical setting of leukocytosis in children. <strong>Methods: </strong>We performed a retrospective study on the children (2-18 years of age) coming to our laboratory Netaji Subhas Medical College & Hospital, Bihta, Patna, Bihar for the period o

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Ruan, Changgeng, Yun Wu, Tokuhiro Okada, et al. "Studies on Reference Intervals for Platelet Counts in Three Cities in China and one in Japan." Thrombosis and Haemostasis 88, no. 07 (2002): 111–14. http://dx.doi.org/10.1055/s-0037-1613162.

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SummaryHematological parameters including platelet counts, etc. were determined in 1,140 healthy subjects living in four cities: Suzhou (Jiangsu Province), Chengdu (Sichuan Province) and Harbin (Heilongjang Province) in China, and Kobe in Japan. Then, the reference intervals for platelet counts were calculated and compared. The reference interval for platelet count of subjects aged between 18 and 60 years was 60-259 × 109/L in Suzhou and 52–202 × 109/L in Chengdu, and subjects with platelet counts of 100 × 109/L or less accounted for about 30% of the subjects examined in these cities. The refe

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Moffat, Karen A., Menaka Pai, Yang Liu, et al. "An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts." Thrombosis and Haemostasis 100, no. 07 (2008): 01–12. http://dx.doi.org/10.1160/th08-03-0183.

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SummaryLight transmission platelet aggregation tests are important for diagnosing platelet function defects. However, uncertainties exist about the best procedures to determine aggregation reference intervals. We investigated methods for determining reference intervals for light transmission aggregation tests, using the % maximal aggregation values for prospectively collected data on healthy control samples. Reference intervals for samples tested at 250 x 109 platelets/l were determined by mean ± 2 standard deviations and non-parametric analyses. To establish reference intervals for tests on t

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Chu, Ying-Hsia, William Nicholas Rose, William Nawrot, and Thomas J. Raife. "Pooled platelet concentrates provide a small benefit over single-donor platelets for patients with platelet refractoriness of any etiology." Journal of International Medical Research 49, no. 5 (2021): 030006052110167. http://dx.doi.org/10.1177/03000605211016748.

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Background At our institution, patients with platelet refractoriness (of any etiology) are sometimes switched from apheresis platelets to pooled platelets before human leukocyte antigen (HLA)-matched units become available. Study design and methods Seven patients were analyzed. Platelet counts were available from 57 single-unit transfusions (26 pooled, 31 apheresis). A mixed linear effects model was used and significance was determined using a likelihood ratio test. Results When analyzed as the only fixed effect in the model, the use of pooled versus single-donor units and time from transfusio

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Farner, Beate, Hartmut Kroll, Thomas Kohlmann, Theodore E. Warkentin, Petra Eichler, and Andreas Greinacher. "Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis." Thrombosis and Haemostasis 94, no. 07 (2005): 132–35. http://dx.doi.org/10.1160/th04-12-0825.

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SummaryImmune mediated heparin induced thrombocytopenia (HIT) is a prothrombotic adverse effect of heparin. However, only a subgroup of patients with HIT develops thromboembolic complications. We aimed to identify risk factors for developing HITassociated thrombosis. We analyzed a registry of patients with clinical suspicion of HIT who tested positive using a sensitive functional assay. Patient information was obtained by a standardized questionnaire. By multivariate analysis the association of age, gender, type of patient population, and magnitude of the platelet count decline with the freque

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Hirashima, Yutaka, Hideo Hamada, Masanori Kurimoto, Hideki Origasa, and Shunro Endo. "Decrease in platelet count as an independent risk factor for symptomatic vasospasm following aneurysmal subarachnoid hemorrhage." Journal of Neurosurgery 102, no. 5 (2005): 882–87. http://dx.doi.org/10.3171/jns.2005.102.5.0882.

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Object. Increased platelet consumption is expected in patients with cerebral vasospasm, according to data from clinical and experimental studies. The authors investigated sequential changes in platelet counts in patients with subarachnoid hemorrhage (SAH) and the difference in platelet consumption between patients with and those without symptomatic vasospasm (SV). Variables related to platelet count as well as other clinical and radiological variables were analyzed as independent predictors of SV. Methods. One hundred consecutive patients who had undergone surgery within 48 hours after SAH ons

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Khan, Sunia Qasuria, Muhammad Kaleem Khan, Yasar Mehmood Yousafzai, et al. "Platelet-Lymphocyte Ratio Dynamics and Severity Correlation in COVID-19: Insights from Platelet Count Variations." Journal of Saidu Medical College, Swat 15, no. 1 (2025): 76–81. https://doi.org/10.52206/jsmc.2025.15.1.1000.

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Background: COVID-19, driven by the novel β-Coronavirus, significantly affects hematological parameters. Platelet count, Platelet-Lymphocyte and Neutrophil-Lymphocyte Ratios have been recommended as potential signs of disease severity. This study aimed to evaluate the relationship between platelet count, PLR, and the severity of COVID-19 in hospitalized patients.Objective: To assess the association of Platelet-Lymphocyte Ratios, platelet count, and disease severity in hospitalized COVID-19 patients and determine their potential as prognostic markers.Materials and Methods: In this prospective s

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Rana, Himanshu, and Mahvesh Sheikh. "ESTIMATION AND COMPARISON OF PLATELET COUNT: AUTOMATED ANALYZERVS MANUAL PERIPHERAL SMEAR METHOD." International Journal of Advanced Research 11, no. 08 (2023): 621–28. http://dx.doi.org/10.21474/ijar01/17430.

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Accurately assessing platelet counts holds paramount importance in the realm of diagnostics and treatment. The adoption of automated methods within the diagnostic landscape is steadily growing, attributed to their multifaceted benefits. Nonetheless, automated analyzers sometimes yield erroneous results, particularly in scenarios involving particles of comparable sizes or instances of light scattering. These encompass fragmented red blood cells (RBCs), microcytic RBCs, and the presence of oversized platelets or platelet clusters. In response, the manual estimation of platelet counts using Leish

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Frelinger, Andrew L., Anja J. Gerrits, Michelle A. Berny-Lang, et al. "Association Of Platelet Function Markers, Independent Of Platelet Count, With Bleeding Score In Patients With Immune Thrombocytopenia." Blood 122, no. 21 (2013): 3534. http://dx.doi.org/10.1182/blood.v122.21.3534.3534.

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Abstract Background Immune thrombocytopenia (ITP) patients with similarly low platelet counts differ in their tendency to bleed. Aim To determine if differences in platelet function in ITP patients with similarly low platelet counts partly account for the variation in bleeding tendency. Methods The relationship between bleeding scores and platelet function markers was investigated in a single center cross-sectional study of pediatric patients with ITP. Following informed consent, blood was collected from ITP patients and bleeding was graded using the Buchanan and Adix Score (J Pediatr 2002) at

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Arnold, Donald M., Jane C. Moore, James W. Smith, and John G. Kelton. "An Individual Platelet Count Set-Point in ITP: A Concept Learned from Patients with Mild Thrombocytopenia and a Good Response to IVIg or Corticosteroids." Blood 110, no. 11 (2007): 3926. http://dx.doi.org/10.1182/blood.v110.11.3926.3926.

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Abstract Background: Immune thrombocytopenic purpura (ITP) is a heterogeneous disease caused by both increased platelet destruction and decreased platelet production. Thrombocytopenia is typically severe, and in the absence of a sensitive and specific test, a platelet count response to intravenous immune globulin (IVIg) or corticosteroids is diagnostic. Patients with mild thrombocytopenia (platelets 50 – 150 × 109/L) may have ITP, non-immune thrombocytopenia or a low-normal platelet count. The diagnostic value of platelet autoantibodies for such patients is not known. Methods: We studied the p

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Yang, Jing, Xiaojun Lu, Tokuhiro Okada, et al. "Effects of biological variations on platelet count in healthy subjects in China." Thrombosis and Haemostasis 91, no. 02 (2004): 367–72. http://dx.doi.org/10.1160/th03-05-0276.

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SummaryThe effects of biological variations on platelet counts were investigated in 694 healthy subjects aged 18 to 60 years living in three cities including Chengdu (Sichuan Province), Suzhou (Jiangsu Province) and Harbin (Heilongjang Province) in China. Platelet counts in healthy subjects were significantly lower in Chengdu (52∼202 X 109/L) and Suzhou (60∼259 X 109/L) than in Harbin (154∼348 X 109/L)(p <0.0001), but the mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, the MPV values were significantly higher in Chengdu (11.8∼15.6 fl) and Su

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Verma, Seemitr, Ruchee Khana, Vinay Khanna, Saisreeram Kandula, Vikram Ram Rajgopal, and Vishnu Prasad. "Platelet-based biomarkers: A new frontier in inflammation monitoring for respiratory infections." F1000Research 14 (March 25, 2025): 328. https://doi.org/10.12688/f1000research.161124.1.

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Background Platelets play a crucial role in haemostasis and have emerging functions in inflammation, particularly in respiratory infections like pulmonary tuberculosis (PTB) and pneumonia. The objective of this study was to investigate alterations in platelet parameters and their relationship with erythrocyte sedimentation rate (ESR) in PTB and pneumonia patients, comparing them to healthy controls, to evaluate their diagnostic and prognostic potential. Methods This retrospective case-control study was conducted at a tertiary care center, involving 450 participants: 158 PTB patients, 142 pneum

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Reh Naz Shaikh, Saba Leeza, Masood Nabi Noor, Nida, Muhammad Muqeem Mangi, and Masood Ahmed Unar. "Examination stress: Effects on Quantitative Platelet count in medical students at Peoples University of medical and health sciences for women, Nawabshah." Professional Medical Journal 30, no. 10 (2023): 1362–66. http://dx.doi.org/10.29309/tpmj/2023.30.10.7693.

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Objective: To evaluate the examination stress on Quantitative Platelet count in medical students at Peoples University of medical and health sciences for women, Nawabshah. Study Design: Cross-sectional Comparative study. Setting: Department of Physiology, Peoples University of Medical & Health Sciences for Women, Shaheed Benazir Abad. Period: April to October 2019. Material & Method: A randomized selection of female students from Peoples University of medical and health sciences for women, Nawabshah was done. Blood samples were taken before and during the exams after a preliminary medi

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Triplett, Douglas A. "Coagulation and Bleeding Disorders: Review and Update." Clinical Chemistry 46, no. 8 (2000): 1260–69. http://dx.doi.org/10.1093/clinchem/46.8.1260.

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Abstract Hemostasis is initiated by injury to the vascular wall, leading to the deposition of platelets adhering to components of the subendothelium. Platelet adhesion requires the presence of von Willebrand factor and platelet receptors (IIb/IIIa and Ib/IX). Additional platelets are recruited to the site of injury by release of platelet granular contents, including ADP. The “platelet plug” is stabilized by interaction with fibrinogen. In this review, I consider laboratory tests used to evaluate coagulation, including prothrombin time, activated partial thromboplastin time, thrombin time, and

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Melemenidis, Stavros, Khoa D. Nguyen, Rosella Baraceros-Pineda, et al. "Rapid Sterilization of Clinical Apheresis Blood Products Using Ultra-High Dose Rate Radiation." International Journal of Molecular Sciences 26, no. 6 (2025): 2424. https://doi.org/10.3390/ijms26062424.

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Blood products, including apheresis platelets and plasma, are essential for medical use but pose risks of bacterial contamination and viral transmission. Platelets are prone to bacterial growth due to their storage conditions, while plasma requires extensive screening. This study explores rapid irradiation as an innovative pathogen reduction method. A clinical linear accelerator was configured to deliver ultra-high dose rate (6 kGy/min) irradiation to platelet and plasma components. Platelets spiked with Escherichia coli (E. coli; 10⁵ colony-forming units) were irradiated at 0.1–20 kGy, follow

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16

Fujisawa, K., P. Tani, L. Piro, and R. McMillan. "The effect of therapy on platelet-associated autoantibody in chronic immune thrombocytopenic purpura." Blood 81, no. 11 (1993): 2872–77. http://dx.doi.org/10.1182/blood.v81.11.2872.2872.

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Abstract Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder due to autoantibody-induced destruction of platelets. Several forms of therapy have been used, including corticosteroids, splenectomy, danazol, and a variety of immunosuppressants. We studied the mechanism of action of some of these treatments by evaluating patients' platelet- associated autoantibodies (PAAb) and platelet count before and serially following therapy. Treatment with corticosteroids, splenectomy, cyclophosphamide, and combination chemotherapy resulted in a progressive decrease in PAAb associated with

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Fujisawa, K., P. Tani, L. Piro, and R. McMillan. "The effect of therapy on platelet-associated autoantibody in chronic immune thrombocytopenic purpura." Blood 81, no. 11 (1993): 2872–77. http://dx.doi.org/10.1182/blood.v81.11.2872.bloodjournal81112872.

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Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder due to autoantibody-induced destruction of platelets. Several forms of therapy have been used, including corticosteroids, splenectomy, danazol, and a variety of immunosuppressants. We studied the mechanism of action of some of these treatments by evaluating patients' platelet- associated autoantibodies (PAAb) and platelet count before and serially following therapy. Treatment with corticosteroids, splenectomy, cyclophosphamide, and combination chemotherapy resulted in a progressive decrease in PAAb associated with an impro

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18

Ryan, Sarah, Yang Liu, Sheharyar Raza, et al. "Substantial Variability in Platelet Transfusion Practice in a Patient-Level Audit of 56,204 Transfusions across 22 Hospitals." Blood 144, Supplement 1 (2024): 5599. https://doi.org/10.1182/blood-2024-209033.

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Introduction: Platelet transfusions are the second most commonly transfused blood product after red blood cells, with over 2 million units transfused annually in the United States. Despite randomized trials and evidence-based guidelines, recent audits have found high rates of unnecessary transfusion, ranging from 22% to 42%, driven primarily by prophylactic transfusion in non-bleeding patients at a threshold over 10,000/uL. Our multicenter, retrospective observational study sought to characterize transfused patients, assess time trends, and describe variability in pre-transfusion platelet coun

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Ibrahim, Shafaf, Muhammad Faris Afiq Fauzi, Nur Nabilah Abu Mangshor, Raihah Aminuddin, and Budi Sunarko. "Automated Platelet Counter with Detection Using K-Means Clustering." Annals of Emerging Technologies in Computing 7, no. 5 (2023): 39–49. http://dx.doi.org/10.33166/aetic.2023.05.004.

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Platelet is a blood cell type that is stored and circulated in the human body. It acts as a blood thickening agent and prevents blood from overflowing whenever bleeding occurs. An excessive or inadequate number of platelets could lead to platelet-related diseases. The current practice of platelet counting involves the manual counting process using a haemocytometer, Wright’s Stain which uses the dyes to facilitate the differentiation of blood cell types, and a tally counter. Yet, this process can be time-consuming, demanding, and exhausting for haematologists, and likely to be prone to errors.

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Arlt, Nicole, Remo Rothe, and Rainer Moog. "Validation of blood counters for quality control of platelet concentrates with high platelet counts." Journal of Laboratory Medicine 42, no. 5 (2018): 201–4. https://doi.org/10.1515/labmed-2018-0306.

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Abstract Background Blood counters are primarily used to measure peripheral blood cells including platelets (PLTs). In routine quality control of platelet concentrates (PCs), counters are also used to analyze very high PLT counts. To meet the requirements of national and European guidelines for quality assurance, the accuracy of counting very high PLT counts has to be validated. The aim of the present study was to validate four blood counters (one of which has two detection methods) focusing on the PLT count. Methods The comparison was performed with PCs using the blood counter devices CELL-DY

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Çeçen, Serpil, and Zozan Güleken. "The Impact of Increased Platelet Count on Erythrocyte Aggregation in Obese Individuals without Cardiovascular Disease." Meandros Medical And Dental Journal 26, no. 2 (2025): 151–56. https://doi.org/10.69601/meandrosmdj.1607649.

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Introduction: Although obesity raises the risk of cardiovascular illnesses, it is an important issue for public health. Platelets play important role in thrombosis and inflammation, and elevated number of platelets has been noted in obese individuals. Erythrocyte aggregation process involving the clumping of red blood cells, is influenced factors, including platelet activation. To investigate the relationship amongst platelet levels and erythrocyte aggregation in obese individuals. Methods: Anthropometric measurements of obese individuals (n=101) and non-obese controls (n=37) were recorded. Er

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Moulis, Guillaume, Christian Fynbo Christiansen, Bianka Darvalics, Ina Trolle Andersen, Henrik Toft Sørensen, and Mette Nørgaard. "Platelet Count upon Acute Hospital Admission to Internal Medicine Units Is a Predictor of Mortality in Adults: A Danish Cohort Study." Blood 132, Supplement 1 (2018): 3578. http://dx.doi.org/10.1182/blood-2018-99-112457.

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Abstract Introduction: Aside of their hemostatic role, platelets have pleiotropic effects and play a role in acute conditions, including host defense against various pathogens. Therefore, the initial platelet count upon acute hospital admission might be a prognostic marker for mortality. This prediction study assessed the relation between platelet count upon acute admission to internal medicine units and mortality. Methods: We included all adults (>15 years old) in the North and Central Denmark Regions who had a first-time acute admission to an internal medicine unit during 2006-2012. We ca

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Sun, Dandan, Quanliang Wang, Jie Kang, et al. "Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study." Cardiology Research and Practice 2021 (March 22, 2021): 1–9. http://dx.doi.org/10.1155/2021/9039610.

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Background. The risk of cognitive impairment in patients with atrial fibrillation is significantly increased. Its occurrence may be related to blood hypercoagulable state and immune inflammatory reaction. Platelets can mediate immune inflammatory response, but there is no evidence about the relationship between platelet count and cognitive function in patients with atrial fibrillation. Purpose. To explore whether there is a certain correlation between platelet count and cognitive function in patients with atrial fibrillation. Methods. A cross-sectional study was conducted in a single center in

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Aygün, Demet, and Hüseyin Doğu. "Evaluation of hematologic inflammation parameters and cranial magnetic resonance imaging findings in patients with trigeminal neuralgia." Journal of Health Sciences and Medicine 8, no. 2 (2025): 197–203. https://doi.org/10.32322/jhsm.1556900.

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Aims: This study aimed to evaluate the relationship between trigeminal neuralgia (TN) and hematological parameters, including leukocyte-based inflammatory indices, and to explore their association with cranial magnetic resonance imaging (MRI) findings. Methods: A retrospective analysis was conducted on 114 patients with newly diagnosed TN and 114 healthy control groups with comparable demographic characteristics. Clinical, laboratory, and cranial MRI data were collected from hospital records. White matter abnormalities were identified via cranial MRI, and inflammatory indices were calculated a

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Bowhay-Carnes, Elizabeth, Yuliya Kreychman, Lucas Buxman, and Leslie Todd. "Real-World Experience with Combination Therapy of Fostamatinib and Thrombopoetin Receptor Agonists (TPO-RAs) for Treatment of Immune Thrombocytopenia (ITP): Patient-Reported Outcomes." Blood 144, Supplement 1 (2024): 5080. https://doi.org/10.1182/blood-2024-204078.

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Background Immune thrombocytopenia (ITP) is a complex disease that ebbs and flows over time. Multiple mechanisms of disease may be present, including increased destruction of auto-antibody-bound platelets by macrophages, increased production of anti-platelet antibodies by B-cells, and decreased production of platelets by antibody-bound megakaryocytes. Fostamatinib is a spleen tyrosine kinase (SYK) inhibitor that prevents platelet destruction and abrogates B-cell activation thereby decreasing plasma cell production of antibodies. Thrombopoietin receptor agonists (TPO-RA) stimulate megakaryocyte

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Sande, Christopher, Seth Maliske, M. Bridget Zimmerman, Dennis Aaron Reinke, Usha Perepu, and Carol Holman. "Impact of Splenectomy on Postsurgical Platelet Count." American Journal of Clinical Pathology 152, Supplement_1 (2019): S24—S25. http://dx.doi.org/10.1093/ajcp/aqz112.047.

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Abstract This study investigates both the short- and long-term effects of splenectomy on platelet count. Methods Patients treated at our tertiary care center in years 2012-2016 with a history of splenectomy (assessed by corresponding ICD-9 and ICD-10 codes) were included if they had platelet count data available within the first 5 years postsplenectomy. Indication for and date of splenectomy as well as all platelet counts were extracted. Patients were sorted by splenectomy indication into ITP, clonal myeloid neoplasm, nonmyeloid malignancy, and trauma/other categories. ITP patients were divide

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Zelmanovic, David, and Edward J. Hetherington. "Automated Analysis of Feline Platelets in Whole Blood, Including Platelet Count, Mean Platelet Volume, and Activation State." Veterinary Clinical Pathology 27, no. 1 (1998): 2–9. http://dx.doi.org/10.1111/j.1939-165x.1998.tb01071.x.

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Carville, David G. M., Patricia A. Schleckser, Kirk E. Guyer, Michael Corsello, and Mark M. Walsh. "Whole Blood Platelet function Assay on the /CHOR^TM Point-of-Care Hematology Analyzer." Journal of ExtraCorporeal Technology 30, no. 4 (1998): 171–77. http://dx.doi.org/10.1051/ject/1998304171.

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The role of platelets as the initial defense against insult to the vasculature is well established. Moreover, platelets are now recognized as having a critical role in the acute care settings of cardiopulmonary bypass (CPB) procedures and cardiac catheterization. In the environment of CPB, both platelet count and function have been demonstrated as being markedly compromised during and following the procedure. Unfortunately, current assays that are used to evaluate the parameters of platelet count and function are limited in regard to their utility in a near patient format. Here, we describe a

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Ganjar Noviar, Eem Hayati, and Riski Nur Ramadhani. "THE EFFECTIVENESS OF PAPAYA LEAF EXTRACT (CARICA PAPAYA L.) AS AN ANTIAGGREGATION AGENT ON PLATELET COUNT AND PLATELET AGGREGATION: IN VITRO STUDY." Journal of Vocational Health Studies 9, no. 1 (2025): 38–46. https://doi.org/10.20473/jvhs.v9.i1.2025.38-46.

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Background: In hypertensive patients, platelet hyperaggregation may lead to acute ischemic stroke, which can increase mortality or neurological deficits. Papaya (Carica papaya L.) has potential effect to mitigate complications arising from hyperaggregation, because its effectiveness as antiplatelet aggregants. Purpose: The aim of this study was to determine the effectiveness of papaya leaf extract as an antiaggregation on platelet count and platelet aggregation. Method: A quasi-experimental design was adopted observing platelet counts utilizing a hematology analyzer medonic M32 and assessing p

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Arlt, Nicole, Remo Rothe, and Rainer Moog. "Validation of blood counters for quality control of platelet concentrates with high platelet counts." LaboratoriumsMedizin 42, no. 5 (2018): 201–4. http://dx.doi.org/10.1515/labmed-2018-0062.

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AbstractBackgroundBlood counters are primarily used to measure peripheral blood cells including platelets (PLTs). In routine quality control of platelet concentrates (PCs), counters are also used to analyze very high PLT counts. To meet the requirements of national and European guidelines for quality assurance, the accuracy of counting very high PLT counts has to be validated. The aim of the present study was to validate four blood counters (one of which has two detection methods) focusing on the PLT count.MethodsThe comparison was performed with PCs using the blood counter devices CELL-DYN Ru

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Ahmed, Sawer Sabri. "A study to evaluate platelet parameters in patients with type 2 diabetes mellitus: A case-control study." Medical Journal of Babylon 21, no. 1 (2024): 124–28. http://dx.doi.org/10.4103/mjbl.mjbl_408_23.

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Abstract Background: Diabetes mellitus is a multifactorial disorder characterized by persistent elevation of plasma glucose and permanent complications of both small and large vessels. The high mortality rates, a decline in quality of life, and high morbidity rates are mostly caused by these problems. When blood vessels are injured, the normal hemostatic process depends heavily on platelets to maintain their integrity. Objectives: This study aimed at comparing various platelet indices between people with type II diabetes and people who appeared to be in good health status. Materials and Method

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Harsh H. Patel, Harsha D. Makwana, and Supriya D. Malhotra. "Linezolid Induced Thrombocytopenia: A Case Report." Innovative Journal of Medical and Health Science 11, no. 05 (2021): 1702–4. http://dx.doi.org/10.15520/ijmhs.v11i05.3307.

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Linezolid (LZD) is an antimicrobial agent with a broad spectrum of activity against virtually all clinically important Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCoNS) and vancomycin-resistant enterococci (VRE). Thrombocytopenia (TP) is a common adverse effect of Linezolid (LZD). Prolonged treatment duration, renal insufficiency, chronic liver disease, malignancy, previous vancomycin use, baseline platelet count, and lower body weight have been reported as possible risk factors for LZD-associat

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Ahn, Eugene R., John J. Byrnes, Vincenzo Fontana, Pamela Dudkiewicz, Carlos J. Bidot, and Yeon S. Ahn. "Recurrence of Severe ITP Following Administration of G-CSF: Remission Following Platelet and Vinca-Alkaloid Infusion." Blood 110, no. 11 (2007): 3222. http://dx.doi.org/10.1182/blood.v110.11.3222.3222.

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Abstract Introduction: In ITP, platelets opsonized with antibodies are phagocytosed by macrophages. Activation of macrophages often triggers aggravation or relapses of ITP as demonstrated following vaccination, infections. G-CSF stimulates granulocyte colonies but can stimulate macrophages at higher concentrations in vitro. We report recurrence of severe life threatening ITP following G-CSF therapy, successfully managed by selective injury of macrophages with sequential infusions of platelets and vinca-alkaloids. Case Study: A 30 year old healthy Caucasian man developed severe ITP in 9/03 with

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Fogagnolo, Alberto, Gianluca Calogero Campo, Matilde Mari, et al. "The Underestimated Role of Platelets in Severe Infection a Narrative Review." Cells 11, no. 3 (2022): 424. http://dx.doi.org/10.3390/cells11030424.

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Beyond their role in hemostasis, platelets have emerged as key contributors in the immune response; accordingly, the occurrence of thrombocytopenia during sepsis/septic shock is a well-known risk factor of mortality and a marker of disease severity. Recently, some studies elucidated that the response of platelets to infections goes beyond a simple fall in platelets count; indeed, sepsis-induced thrombocytopenia can be associated with—or even anticipated by—several changes, including an altered morphological pattern, receptor expression and aggregation. Of note, alterations in platelet function

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Hana, Caroline, Samar Aboulenain, Nakeya Dewaswala, and Vijay Narendran. "Does Thrombocytopenia Truly Correlate with COVID-19 Severity?" Blood 136, Supplement 1 (2020): 39–40. http://dx.doi.org/10.1182/blood-2020-142440.

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Introduction: On March 11, 2020, the World Health Organization (WHO) declared SARS-CoV-19 a pandemic with about 114 countries affected. Many studies and metanalyses have investigated the risk factors associated with poor outcomes from COVID-19 infection. Different clinical as well as laboratory parameters have been shown to correlate with disease severity, including age, male gender, smoking history, presence of one or more co-morbidities, heart disease, hypertension, diabetes, obesity, and chronic lung disease. Among these risk factors, several studies suggest that a decreased platelet count

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Uhl, Cindy B., Ryan L. Barness, Mary C. Olson, et al. "Platelet Storage Pool Deficiency: Establishment Of Reference Ranges For Platelet Dense Granule Count By Transmission Electron Microscopy." Blood 122, no. 21 (2013): 3549. http://dx.doi.org/10.1182/blood.v122.21.3549.3549.

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Abstract Background Platelet dense granule (DG) deficiencies, including Hermansky-Pudlak syndrome, are relatively common and frequently under-diagnosed hereditary platelet hypofunctional disorders. Among various laboratory tests, platelet whole mount (WM) transmission electron microscopy (TEM) is considered the gold standard method for diagnosing DG deficiencies. Nevertheless, platelet DG TEM testing is still largely a research tool and has not been thoroughly validated and standardized as a clinical test. Furthermore, reference ranges (RR) of DG count/platelet (DGC) have not been adequately e

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Zama, Rizwan U., Naushad Ali N. Malagi, A. N. Thobbi, and Salim A. Dhundasi. "A clinical study of spectrum of low platelet count to establish etiology, diagnosis, complications and prognosis in newborns admitted in Al-Ameen medical college hospital NICU, Bijapur, Karnataka, India." International Journal of Contemporary Pediatrics 7, no. 7 (2020): 1451. http://dx.doi.org/10.18203/2349-3291.ijcp20202569.

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Background: In the newborn low platelet count is a common finding in both preterm and term newborn. It has been estimated that as many as 22% of all new borns admitted to NICU develop low platelet counts. A platelet count of less than 150,000/mL is defined as thrombocytopenia irrespective of the age of the individual.Methods: All the neonates underwent necessary blood investigations like Complete blood counts, (including platelet counts, HB estimation, Red cell indices and PCV), Capsular Polysaccharide - reactive protein. (CRP), Peripheral Smear study, Blood culture, BT, CT, PT, aPPT, Anti-pla

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Sikumbang, Aditya Paelo Rizki, Indranila Kustarini Samsuria, Novi Anggriyani, and Charles Limantoro. "THE DIFFERENCE OF MEAN PLATELET VOLUME AND PLATELET COUNT IN CORONARY HEART DISEASE PATIENTS WITH ACUTE CORONARY SYNDROME AND NON ACUTE CORONARY SYNDROME." DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) 10, no. 2 (2021): 118–23. http://dx.doi.org/10.14710/dmj.v10i2.29460.

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Background: Coronary Heart Disease (CHD) is currently one of main causes and the first death in developed and developing countries, including Indonesia. CHD appeared with the clinical appearance of asymptomatic, stable angina pectoris until acute coronary syndrome. ACS is a progressively CHD and takes parameters that describe the process pathogenesis. MPV and platelet count are two parameters in the complete blood count which reflect the activity of platelets in CHD.Objective: This study is to investigate the differences Mean Platelet Volume and Platelet Count in CHD with ACS compared to non A

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Tao, Derrick L., Samuel Tassi Yunga, Craig D. Williams, and Owen J. T. McCarty. "Aspirin and antiplatelet treatments in cancer." Blood 137, no. 23 (2021): 3201–11. http://dx.doi.org/10.1182/blood.2019003977.

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Abstract Platelets have been hypothesized to promote certain neoplastic malignancies; however, antiplatelet drugs are still not part of routine pharmacological cancer prevention and treatment protocols. Paracrine interactions between platelets and cancer cells have been implicated in potentiating the dissemination, survival within the circulation, and extravasation of cancer cells at distant sites of metastasis. Signals from platelets have also been suggested to confer epigenetic alterations, including upregulating oncoproteins in circulating tumor cells, and secretion of potent growth factors

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Nandi, Seema, and Ashley C. Brown. "Platelet-mimetic strategies for modulating the wound environment and inflammatory responses." Experimental Biology and Medicine 241, no. 10 (2016): 1138–48. http://dx.doi.org/10.1177/1535370216647126.

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Platelets closely interface with the immune system to fight pathogens, target wound sites, and regulate tissue repair. Natural platelet levels within the body can be depleted for a variety of reasons, including excessive bleeding following traumatic injury, or diseases such as cancer and bacterial or viral infections. Platelet transfusions are commonly used to improve platelet count and hemostatic function in these cases, but transfusions can be complicated by the contamination risks and short storage life of donated platelets. Lyophilized platelets that can be freeze-dried and stored for long

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Harahap, Novita Sari, Diky Setya Diningrat, and Yetty Machrina. "Effect of Jungga Orange Peel Essential Oil (Citrus Jambhiri) on Platelet Function in Male Rats Given High Intensity Physical Activity." Kinestetik : Jurnal Ilmiah Pendidikan Jasmani 6, no. 3 (2022): 568–73. http://dx.doi.org/10.33369/jk.v6i3.23764.

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Physical activity is one of the stress factors that can provide physiological changes to the function of the hematological system such as changes in platelet count. Physical activity can produce free radicals that can result in cell damage including platelets. Platelets play a role in the hemostasis process, If the platelet count is too low, it can cause excessive bleeding. However, if there is an increase in platelet count too high, it can cause thrombosis that can inhibit blood vessels. Antioxidants have a protective effect on cells and eliminate free radicals. The objective of this research

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Murtagh, Kathleen, Jacquie Toia, Tonya Scardina, Anne H. Rowley, and Leena B. Mithal. "1146. Thrombocytosis in Infants with Congenital Cytomegalovirus Infection Being Treated with Valganciclovir." Open Forum Infectious Diseases 7, Supplement_1 (2020): S600. http://dx.doi.org/10.1093/ofid/ofaa439.1332.

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Abstract Background Congenital CMV (cCMV) is associated with sensorineural hearing loss and neurodevelopmental disabilities. Infants with symptomatic cCMV infection benefit from 6 months of oral valganciclovir (vGCV) therapy. Neutropenia, thrombocytopenia, and hepatotoxicity are adverse effects vGCV, for which we monitor. We observed a pattern that cCMV infants treated with vGCV developed an uptrend in platelets and/or thrombocytosis (platelet count &gt;450,000/uL) while on therapy. This observation has not previously been reported. Methods Medical records and laboratory results from our m

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Tremblay, Douglas, Zaker I. Schwabkey, Yosef Joseph Rene Amel Riazat-Kesh, et al. "Prevalence and Prediction of Ruxolitinib Treatment Emergent Thrombocytopenia in Myelofibrosis." Blood 142, Supplement 1 (2023): 1830. http://dx.doi.org/10.1182/blood-2023-179937.

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Introduction Ruxolitinib (rux) treatment for myelofibrosis (MF) is frequently complicated by the development of thrombocytopenia, leading to dose reduction and treatment discontinuation, an event which is associated with poor outcomes. With the recent availability of JAK inhibitors that are safe and effective in thrombocytopenic MF patients, identifying predictors for rux-induced thrombocytopenia may allow for personalized JAK inhibitor selection in the upfront setting. Methods We conducted a retrospective cohort study of JAK inhibitor naïve MF patients treated with rux at two large academic i

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Cho, Yong Gon, Jae Hyun Lee, Dal Sik Kim, Hye Soo Lee, and Sam Im Choi. "Clinical Usefulness of the Simple Technique To Diagnose Thrombocytopenia Using Immature Platelet Fraction (IPF)." Blood 108, no. 11 (2006): 3950. http://dx.doi.org/10.1182/blood.v108.11.3950.3950.

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Abstract Background : It is defined that immature platelet fraction (IPF) is the percentage of reticulated platelet (RP) of total platelet count. We have measured an IPF reference range using XE-2100 blood cell counter with upgraded software (Sysmex, Kobe, Japan) and evaluated the clinical utility of this parameter for the laboratory diagnosis of thrombocytopenia due to increased peripheral platelet destruction. Materials and methods : Peripheral blood samples collected into K2EDTA (Beckton Dickinson, Franklin Lakes, NJ, USA) were analysed at Chonbuk National University Hospital. 142 samples f

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Yogesh, Chandra Sharma, and Sharma Shalini. "Assessment of Platelet Indices and Counts and Their Impact in Pre- and During Eclampsia." International Journal of Toxicological and Pharmacological Research 12, no. 9 (2022): 388–95. https://doi.org/10.5281/zenodo.11505365.

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<strong>Background: </strong>Three to eight percent of pregnancies are complicated by preeclampsia, one of the primary health issues that contribute to maternal morbidity and mortality. Preeclampsia’s pathophysiology has been theorized to be influenced by changes in coagulation and fibrinolysis. The most serious health danger to both the mother and the fetus during pregnancy is preeclampsia. The use of platelet characteristics in preeclampsia diagnosis is not expanding in Ethiopia, despite the fact that they are one of the proposed indicators for the prediction of preeclampsia. Pree

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Lee, Robert Hugh, and Wolfgang Bergmeier. "Impact of Platelet Count on Bleeding in the Setting of Anti-Platelet Therapy." Blood 136, Supplement 1 (2020): 18. http://dx.doi.org/10.1182/blood-2020-142893.

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Anti-platelet therapy (APT) is used for secondary prevention of thrombosis. The most commonly prescribed anti-platelet drugs are aspirin and P2Y12 inhibitors, including clopidogrel, prasugrel and ticagrelor. Dual anti-platelet therapy (DAPT) consisting of aspirin and a P2Y12 inhibitor is often used in the first 1-12 months after an initial thrombotic event and has a greater anti-thrombotic effect than single agents, but is also associated with a higher risk of bleeding. Due to this risk of hemorrhage, the appropriate use of DAPT in patients requiring percutaneous coronary intervention (PCI) wi

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Sande, Christopher M., Seth M. Maliske, M. Bridget Zimmerman, Dennis Aaron Reinke, Usha Perepu, and Carol J. Holman. "Impact of Splenectomy on Post-Surgical Platelet Count." Blood 132, Supplement 1 (2018): 4981. http://dx.doi.org/10.1182/blood-2018-99-109980.

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Abstract Introduction: Splenectomy is performed for several conditions, some of which include trauma, immune thrombocytopenia (ITP), clonal myeloid neoplasms, and malignancy. Removal of the spleen can lead to reactive thrombocytosis, with an incidence of approximately 75% to 82%. While it is known that platelet counts frequently increase post-splenectomy, the exact timing of the increase, as well as how much of an increase is expected based on the diagnosis at splenectomy has not been systematically studied. To address this knowledge gap, a retrospective analysis of platelet counts in patients

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Jansen, A. J. Gerard, Hui Zhi Low, Judith van den Brand, Debbie van Riel, Albert Osterhaus, and Erhard van der Vries. "Platelets Can Phagocytose Influenza Virus Which May Contribute to the Occurrence of Thrombocytopenia during Influenza Infection." Blood 128, no. 22 (2016): 1358. http://dx.doi.org/10.1182/blood.v128.22.1358.1358.

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Abstract Thrombocytopenia is a common and sometimes life-threatening symptom in patients with influenza, which indicates that platelets may play a significant role during virus infection. However, the mechanisms underlying influenza associated thrombocytopenia are still unclear to date. In this study, the relationship between platelets and influenza infection was studied in vivo and in vitro. In the period 2009-2012 we randomly measured viral load and platelet count in laboratory-confirmed influenza patients (A/H1N1 subtype; n=85) presented at the emergency department of Erasmus MC. In a cross

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Sheppard, Jo-Ann, Theodore Warkentin, and Andrew Shih. "Platelet count recovery and seroreversion in immune HIT despite continuation of heparin: further observations and literature review." Thrombosis and Haemostasis 117, no. 10 (2017): 1868–74. http://dx.doi.org/10.1160/th17-03-0212.

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SummaryOne of the standard distinctions between type 1 (non-immune) and type 2 (immune-mediated) heparin-induced thrombocytopenia (HIT) is the transience of thrombocytopenia: type 1 HIT is viewed as early-onset and transient thrombocytopenia, with platelet count recovery despite continuing heparin administration. In contrast, type 2 HIT is viewed as later-onset (i. e., 5 days or later) thrombocytopenia in which it is generally believed that platelet count recovery will not occur unless heparin is discontinued. However, older reports of type 2 HIT sometimes did include the unexpected observatio

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Patel, Govind R., and Gopal R. Prajapati. "Platelet Count in Adults with Iron Deficiency Anemia and Its Correlation with Serum Iron Parameters: An Observational Study at a Tertiary Care Center in Northwestern India." Scholars Journal of Applied Medical Sciences 10, no. 6 (2022): 910–16. http://dx.doi.org/10.36347/sjams.2022.v10i06.009.

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Background: Iron deficiency anemia (IDA) is the most common and potentially treatable nutritional anemia in the world. The platelet count is often unpredictable in IDA. It may lead to reactive thrombocytosis and rarely thrombocytopenia. In children with IDA, abnormal platelet counts were seen in several studies. However, studies evaluating abnormalities of platelet count in adults with IDA are scarce. Objectives: This study was aimed to evaluate platelet count abnormalities in adults with IDA and to correlate platelet count with serum iron parameters. Material and Methods: This was a prospecti

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