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Relevant bibliographies by topics / Indazolo[1

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Academic literature on the topic 'Indazolo[1'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Indazolo[1"

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Lind, Natalie M., Natalie S. Joe, Brian S. Newell, and Aimee M. Morris. "High Yielding, One-Pot Synthesis of Bis(1H-indazol-1-yl)methane Catalyzed by 3d-Metal Salts." Reactions 3, no. 1 (2022): 59–69. http://dx.doi.org/10.3390/reactions3010005.

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Synthetic access to poly(indazolyl)methanes has limited their study despite their structural similarity to the highly investigated chelating poly(pyrazolyl)methanes and their potentially important indazole moiety. Herein is presented a high yielding, one-pot synthesis for the 3d-metal catalyzed formation of bis(1H-indazol-1-yl)methane from 1H-indazole utilizing dimethylsulfoxide as the methylene source. Complete characterization of bis(1H-indazol-1-yl)methane is given with 1H and 13C NMR, UV/Vis, FTIR, high resolution mass spectrometry and for the first time, single crystal X-ray diffraction.

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Chen, Dong-Mei, Jia-Yan Liu, Ming Wei, Bing-Wei Wang, Ruo-Han Chu, and Dong-Sheng Chen. "Synthesis of indazolo[5,4-b][1,6]naphthyridine and indazolo[6,7-b][1,6]naphthyridine derivatives." Heterocyclic Communications 25, no. 1 (2019): 15–21. http://dx.doi.org/10.1515/hc-2019-0006.

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AbstractA simple method for the synthesis of the title compounds by an efficient in-situ reduction and cyclization reactions of aromatic aldehydes, tert-butyl 2,4-dioxopiperidine-1-carboxylate and 5-nitro-1H-indazole or 6-nitro-1H-indazole was developed.

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Guan, Zong, Mimoza Gjikaj, and Andreas Schmidt. "2-Ethyl-1-phenylindazolium hexafluorophosphate. N-heterocyclic carbene formation, rearrangement, ring-cleavage reactions, and rhodium complex formation." Zeitschrift für Naturforschung B 70, no. 1 (2015): 83–89. http://dx.doi.org/10.1515/znb-2014-0188.

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Abstract2-Ethyl-1-phenylindazolium hexafluorophosphate was deprotonated by potassium 2-methyl-butan-2-olate to give theN-heterocyclic carbene of indazole, i.e., indazol-3-ylidene. ThisN-heterocyclic carbene undergoes a ring transformation to 9-ethylaminoacridine. Trapping of the carbene with sulfur, silver(I) oxide, and carbonylbis(triphenylphosphane)rhodium(I) chloride resulted in the formation of indazolethione, indazolone (X-ray structure analysis), and carbonylbis(triphenylphosphane)(2-ethyl-1-phenyl-1H-indazol-3-ylidene)rhodium(I) hexafluorophosphate (X-ray structure analysis), respective

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Alam, Ryan M., and John J. Keating. "Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution." Beilstein Journal of Organic Chemistry 17 (August 2, 2021): 1939–51. http://dx.doi.org/10.3762/bjoc.17.127.

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The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient synthesis and isolation of the desired N-1 or N-2 alkylindazole regioisomer can often be challenging and adversely affect product yield. Thus, as part of a broader study focusing on the synthesis of bioactive indazole derivatives, we aimed to develop a regioselective protocol for the synthesis of N-1 alkylindazoles. Initial screening of various con

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Krishnan, Revathy, and Lalitha Appaswami. "CAN catalyzed synthesis of 1H-indazolotriones." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 857–59. https://doi.org/10.5281/zenodo.5636308.

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Department of Chemistry, Periyar University, Salem-636 011, Tamilnadu, India <em>E-mail</em> : lalitha2531@yahoo.co.in We have developed a potential method for the synthesis of biologically active<sup>1</sup> 2,2´-dimethyl-13-phenyl-2,3- dihydro-1<em>H</em>-indazolo[2,1-<em>b</em>]phthalazine-1,6,11(13<em>H</em>)-trione and its derivatives via an one-pot, four-component synthesis of phthalic anhydride, hydrazine, aromatic aldehydes and dimedone in the presence of ceric ammonium nitrate (CAN) at room temperature. The reaction was completed within 30 min yielding 70–90% of the corres

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Godajddr, Bijan, Masoumeh Etamad, and Soghra Soliemani. "Green synthesis and dye propertied of 2H-indazolo [2, 1-b] phthalazinetriones by PEG-MDIL." Oriental Journal of Chemistry 31, no. 2 (2015): 1231–36. http://dx.doi.org/10.13005/ojc/310283.

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S, Zine Babasaheb, Najan Sopan A, Dhonde Shrikant P, and Mazahar Farooqui. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." Der Pharma Chemica 15, no. 3 (2023): 4. https://doi.org/10.5281/zenodo.13319875.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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Babasaheb, S. Zine, A. Najan Sopan, and Farooqui Mazahar. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." DER PHARMA CHEMICA 15, no. 3 (2023): 4. https://doi.org/10.4172/0975-413X.15.3.34-37.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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S, Zine Babasaheb, Sopan A. Najan, Shrikant P. Dhonde, and Mazahar Farooqui. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." Der Pharma Chemica 15, no. 3 (2023): 4. https://doi.org/10.5281/zenodo.10952012.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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Saketi, Jagan Mohana Rao, S. N. Murthy Boddapati, Raghuram M., et al. "Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug." Applied Sciences 10, no. 11 (2020): 3792. http://dx.doi.org/10.3390/app10113792.

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A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a–3j) and their N-methyl derivatives (5a–5j) are evaluated for in vitro anticancer activity against two cancer cell lines, HCT-116 and MDA-MB-231. The results reveal that the indazole derivatives tested display mild to moderate anticancer activities against the cell lines tested.

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Dissertations / Theses on the topic "Indazolo[1"

1

Wolski, Katja Margrit. "The Sertoli Cell-Spermatid Junctional Complex : a potential avenue for Male contraception." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001747.

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FRONTANA, URIBE BERNARDO ANTONIO. "Electrosynthese d'heterocycles azotes (indazoles 2-n-substitues et 1-aminoindoles n-substitues) par electrolyse en cellule redox a circulation de nitrobenzenes ortho-substitues." Rennes 1, 1999. http://www.theses.fr/1999REN10041.

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Ce memoire rassemble les travaux dont l'objectif principal etait la valorisation en synthese organique de nitrosobenzenes prepares electrochimiquement. Ainsi, l'utilisation de une cellule redox a circulation a deux electrodes poreuses consecutives de polarites opposees, conduit aux composes aryl nitroso (convenablement substitues). Cette voie de synthese de derives nitroses est plus efficace et plus generale que les methodes traditionnelles. Les nitrosobenzenes prepares ont ete utilises avec succes pour la formation de la liaison n n d'heterocycles azotes (indazoles 2nsubstitues et 1aminoindol

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劉翰駿. "Methods for the Regioselective Syntheses of 1-Alkyl-1H-indazoles and 2-Alkyl-2H-indazoles." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/69578237077235341986.

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碩士<br>國立彰化師範大學<br>化學系<br>101<br>We had successfully developed methods for the regioselective syntheses of 1-alkyl-1H-indazoles and 2-alkyl-2H-indazoles. 1.A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles followed by reductive deamination. 2.A method for Ga/ Al-mediated N2–allylation/ benzylation of indazoles in aqueous solution is studied. On the other hand, a simple procedure for SnCl2/ TiCl3-mediated deoximation of ketoximes in an aque

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李宇鈞. "Synthesis and Antiplatelet Activity of Ethyl 4-(1-phenyl-1H-indazol-3-yl)benzoate Analogues." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/17336074864915650784.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>90<br>Recently, ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) has been recognized as a representative of a new class of thrombin receptor antagonist, with unique mechanism of action. Encouraged by the initial result, a series of 1-phenyl analogs (6, 9, 10) was synthesized. The starting material ethyl 4-benzoylbenzoate (3) was treated with phenylhydrazine to yield the ethyl 4-[(phenylhydrazono)(phenyl)methyl] benzoate (4) as a mixture of E- and Z- form isomers. Then compound 4 was then treated with lead tetraacetate in dichloromethane at low

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Chen, Hua-Sin, and 陳華鑫. "Synthesis and biological activities of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivative." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/47453222969722384672.

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博士<br>中國醫藥大學<br>藥物化學研究所<br>96<br>In the previous study, ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) was identified as the first selective non-peptide protease-activated receptor 4 (PAR4) antagonist. In order to develop noel PAR4 antagonist, YD-3 was selected as lead compound. Two series of N1-substituted arylmethyl-3-(4-ethoxycarbonylphenyl)indazole derivatives (I) and N2-substituted arylmethyl-3-(4-ethoxycarbonylphenyl)indazole derivatives (II) were synthesized. The key intermediate, ethyl 4-(1H-indazol-3-yl)- benzoate (8) was prepared according to the know method. Then, compound 8

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Chen, Hua-Sin, and 陳華鑫. "Synthesis and Antiplatelet Activity of Ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) Analogues." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/14381104464913170994.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>90<br>Ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) was first synthesized in our laboratory as a novel thrombin-receptor antagonist. In this study, YD-3 was used as a lead compound and a series of its derivatives (9a—9d, 10a—10n) were prepared. The key intermediate YD-3, was synthesized according to Scheme 6. The starting material ethyl 4-benzoylbenzoate (3) was treated with benzylhydrazine to yield ethyl 4-[(benzylhydrazono)(phenyl)methyl] benzoate (4) as a mixture of E- and Z-form isomers. The hydrazone was then treated with lead tetraacet

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Mei-Ling, Shih, and 石美玲. "Synthesis, Antiplatelet, Antiangiogenesis and Cytotoxicity Activity of 1(or 2)-(Substituted benzyl)-3-(4-methylphenyl)-1(or 2)H-indazoles." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/00339292517678059254.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>90<br>In order to search novel compounds with potent antiplatelet and antiangiogenesis activities, 3-(4-methylphenyl)-1H-indazole (6) was used as the key intermediate and its derivatives were synthesized. In the presence of triethylamine, 1-(N-morpholino)cyclohexene was reacted with 4-methylbenzoyl chloride. Followed by hydrolysis using dil. hydrochloric acid, 2-oxocyclohexyl 4-methylphenyl ketone (4) was obtained. 3-(4-Methylphenyl)-4,5,6,7-tetrahydro-1H-indazole (5) was gained after reaction of compound 4 and hydrazine. The product, 3-(4-methyl phenyl)

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Tsai, Ray-Ying, and 蔡睿盈. "Synthesis，Antiplatelet，Antiangiogenesis and Cytotoxicity Activity of 1-Benzyl-3-(5-substituted-2-furyl)-5-methoxy-1H-indazole Derivatives." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/68278761980375752184.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>91<br>Abstract 1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) was first synthesized in our laboratory as a novel antiplatelet agent. Encouraged by the initial results, a series of 5-methoxy derivatives of YC-1 analogues were synthesized and examined for their biological activities. The starting material methyl 5-(3-methoxybenzoyl)-2-furoate (1) was treated with benzylhydrazine to yield a mixture of E- and Z-form isomers 2. The hydrazone was then treated with lead tetraacetate in dichloromethane at low temperature, then boron trifluoride e

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Book chapters on the topic "Indazolo[1"

1

Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) complex with 2-(1-indazolyl)-benzothiazole." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 3. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62470-8_154.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex with 2-(1-indazolyl)benzothiazole." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 4. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62474-6_424.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) chloride complex of 2-(1-indazolyl)-pyridine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_195.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) chloride complex of 2-(1-indazolyl)-pyrimidine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_196.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) chloride complex of 2-(1-indazolyl)pyridine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45972-0_658.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of manganese(II) chloride complex of 2-(1-indazolyl)-pyridine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45972-0_291.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) chloride complex of 2-(1-indazolyl)-pyrimidine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45972-0_506.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) chloride complex of 2-(1-indazolyl)-pyridine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45972-0_505.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) chloride complex of 2-(1-indazolyl)-pyrimidine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45972-0_659.

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Pardasani, R. T., and P. Pardasani. "Molar magnetic moment of dichloro-bis[2-(1-indazolyl)benzothiazole)]cobalt(II)." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 2. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62466-1_321.

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