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Journal articles on the topic 'Independent inventor'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Petroski, Henry. "An Independent Inventor." American Scientist 86, no. 3 (1998): 222. http://dx.doi.org/10.1511/1998.25.3403.

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2

Crawford, Julia. "Independent Inventor Resources Web Site." Journal of Government Information 28, no. 1 (2001): 113–15. http://dx.doi.org/10.1016/s1352-0237(01)00259-3.

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3

Daemmrich, Arthur. "Inventor-Entrepreneurs: Patents and Patent Licensing in the Early Republic." Technology & Innovation 22, no. 1 (2021): 55–63. http://dx.doi.org/10.21300/21.4.2021.6.

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Independent inventors have limited routes to secure financial returns on the time and capital they invest to develop and realize a new idea. Research into two centuries of inventors has identified their options as licensing patents once they are issued, selling inventions (and patents) to existing companies, forging consulting arrangements with operating firms, or raising funds and starting a business. This article explores patent licensing as an entrepreneurial approach using a case study of the largely unknown licensing program undertaken by Samuel Hopkins after receiving the first U. S. pat

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4

Scott, David W., George W. Wright, Mickey Williams, et al. "Accurate Diagnosis of Aggressive B Cell Non-Hodgkin Lymphomas Using Gene Expression Profiling of Formalin-Fixed, Paraffin-Embedded Tissues." Blood 124, no. 21 (2014): 3016. http://dx.doi.org/10.1182/blood.v124.21.3016.3016.

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Abstract Background: Currently, diagnosis of aggressive B cell non-Hodgkin lymphomas (agg-B-NHL) uses a varying combination of morphology, immunophenotyping, cytogenetics, and/or other molecular techniques resulting in a fragmented, confusing diagnostic system. We sought to develop a multi-analyte gene expression signature assay that could consolidate the diagnostic process into a single platform to improve standardization and accuracy. Methods: We used formalin-fixed, paraffin-embedded tissue biopsies, qualified by an expert Hematopathology review panel, tumor content of ≥60%, and confirmed B

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5

Spear, Brian. "GB innovation since 1950 and the role of the independent inventor: An analysis of completed term patents." World Patent Information 28, no. 2 (2006): 140–46. http://dx.doi.org/10.1016/j.wpi.2005.08.004.

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6

Parlika, Rizky, Olivia i. Anggun Permatasar, Rifardi Taufiq Yufananda, Dimas Rizward Hikmah Utomo, Mochammad Zayyan Ramadhan, and Isfan Rachmad. "PEMBUATAN GAME EDUKATIF MENGGUNAKAN APP INVENTOR DENGAN TEMA MATA PELAJARAN KIMIA." e-NARODROID 4, no. 2 (2018): 1–11. http://dx.doi.org/10.31090/narodroid.v4i2.729.

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Abstract : The problem in this research is to make a suitable learning media applied to high school students as an independent media and interkative, So that the application of learning model used by the teacher is not boring tend to be fun and can improve learning outcomes. The objectives of the researcher to accomplish is to develop and produce android application products in the form of educational media learning games about Chemistry, and know the feasibility and effectiveness of educational game applications as learning media for student study supplement with Chemical material. This resea

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7

Hankey, Alex, and Elena Ewing. "New Light on Chromotherapy: Grakov's ‘Virtual Scanning’ System of Medical Assessment and Treatment." Evidence-Based Complementary and Alternative Medicine 4, no. 2 (2007): 139–44. http://dx.doi.org/10.1093/ecam/nel060.

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Virtual Scanning incorporates novel uses of colored light into its system of health assessment and therapy. Independent investigations of its effectiveness in Russia and the UK have revealed unique abilities to correct incipient and fully developed chronic conditions. As such it forms an important new addition to the field of Chromotherapy. It differs from most others, in that its development depended on discoveries in neuroscience by its inventor, and subsequent application of new models in computational neuroscience.

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8

Smeilus, Gavin, Robert J. Harris, and Andrew Pollard. "Independent inventors and inbound open innovation: using a resource-based approach to create a tool for screening inventor approaches in order to facilitate technology in-licensing." International Journal of Technology Marketing 8, no. 2 (2013): 102. http://dx.doi.org/10.1504/ijtmkt.2013.054078.

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9

Rowlinson, J. S. "Dr Thomas Carver and Lord Kelvin." Notes and Records of the Royal Society 60, no. 2 (2006): 161–70. http://dx.doi.org/10.1098/rsnr.2006.0139.

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Thomas Carver was secretary and assistant to William Thomson, Lord Kelvin, from 1890 to 1894 and maintained close links with him until Kelvin's death in 1907. In the twentieth century Carver became an independent engineer and inventor whose patents were mainly for improvements to textile machinery. These improvements were some of the first successful attempts to introduce electrical devices into what had been traditionally a purely mechanical industry. His patents include what seems to be the earliest proposal to use electro-acoustical echo-sounding for measuring the depth of the sea.

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10

Puy, Cristina, Zoë C. Wong, Erik I. Tucker, et al. "FXII Promotes Coagulation in a FXI and FIX Independent Manner." Blood 120, no. 21 (2012): 3362. http://dx.doi.org/10.1182/blood.v120.21.3362.3362.

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Abstract Abstract 3362 Activation of coagulation factors (F) XII and XI support thrombogenesis through multiple pathways. FXII-deficient mice are more resistant to FeCl3-induced arterial occlusion than either FIX or FXI deficient mice, suggesting that the resistance of FXII-deficient mice to experimental thrombosis is not completely explained by the FXII-FXI-FIX pathway, suggesting the existence of a pathological FXII by-pass, in vivo. The APTT of FXII deficient plasma is longer than the APTT of FXI, FIX, or FX deficient plasmas. We found that addition of 150 nM activated FXII (FXIIa) decrease

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11

Nathoo, Narendra, Frederick K. Lautzenheiser, and Gene H. Barnett. "George W. Crile, Ohio's first neurosurgeon, and his relationship with Harvey Cushing." Journal of Neurosurgery 103, no. 2 (2005): 378–86. http://dx.doi.org/10.3171/jns.2005.103.2.0378.

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✓ Much has been written about Harvey Cushing, his contributions to neurosurgery, and his relationship with many of his contemporaries. Nevertheless, there is no independent report documenting his relationship with Ohio's first neurosurgeon, George W. Crile. Crile's role as a neurosurgeon is limited to the late nineteenth and early twentieth centuries, and he is best remembered for other accomplishments. Father of physiological surgery, pioneering surgeon, innovator, inventor, soldier, and the principal founder of the Cleveland Clinic Foundation, Crile lived during the golden era of surgery, wh

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12

Eide, Christopher A., Samantha L. Savage, Anupriya Agarwal, et al. "Activating Mutations Observed in De Novo Acute Myeloid Leukemia Are Also Present in a Subset of Philadelphia Chromosome (Ph)-Positive Leukemia Patients with BCR-ABL1-Independent Resistance to ABL1 Kinase Inhibitors." Blood 124, no. 21 (2014): 4514. http://dx.doi.org/10.1182/blood.v124.21.4514.4514.

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Abstract The advent of ABL1 tyrosine kinase inhibitors has radically transformed the treatment and outcomes for patients with chronic myeloid leukemia (CML). However, 15-20% of newly diagnosed chronic phase patients demonstrate resistance to imatinib by 5 years, and responses are virtually always transient for patients with blast crisis CML or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Acquisition of point mutations within the BCR-ABL1 kinase domain which compromise drug binding is the most common and well-studied cause of resistance to imatinib, and such mutation

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13

Dahlin, Eric, Mikaela Dufur, and Dallan Flake. "Has the Promise of the Internet Been Realized? Internet Access and Collective Invention among Independent and Organizational Patent Inventors." Social Currents 6, no. 6 (2019): 553–74. http://dx.doi.org/10.1177/2329496519860213.

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The Internet provides individuals with new avenues for knowledge sharing and collaboration, two key ingredients for the production of novelty. Despite the unprecedented access to information and potential collaborators provided by the Internet, however, organizations remain the preeminent site of invention, presumably due to the tremendous resources, technology, and expertise at their disposal. Given the presumption that improved access to the Internet cultivates connectivity and novelty among individuals, on one hand, and the resources organizations can leverage to create novelty, on the othe

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14

Macdonald, Stuart. "HUMAN QUALITIES NECESSARY FOR INVENTION: INDEPENDENT INVENTORS AND THE STIMULUS OF ADVERSITY." Prometheus 7, no. 2 (1989): 333–48. http://dx.doi.org/10.1080/08109028908629078.

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15

Weick, Cynthia Wagner, and Cynthia F. Eakin. "Independent Inventors and Innovation." International Journal of Entrepreneurship and Innovation 6, no. 1 (2005): 5–15. http://dx.doi.org/10.5367/0000000053026400.

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Independent inventors have generally been overlooked in research on innovation. This study helps fill the knowledge gap. A survey of independent inventors in the USA showed that their inventions tended towards hardware/tool, household products, industrial/commercial products, novelty items and toys/games/hobbies. Thirty-nine per cent of the respondents generated sales from their inventions and approximately 20% profited from them. Inventors who established a company to commercialize their inventions were most likely to achieve sales. However, inventors who licensed their inventions were more l

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16

Lin, Jennifer, Henry Chao, and Peterson Julian. "A demand independent inventory model." Yugoslav Journal of Operations Research 23, no. 1 (2013): 129–35. http://dx.doi.org/10.2298/yjor120127021l.

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This paper is an extension of Deng et al. (2007) that was published in the European Journal of Operational Research. We have generalized their model from ramp type demand to arbitrary positive demand while theoretically discovering an important phenomenon: the optimal solution is actually independent of the demand as pointed out by Wou (2010), Hung (2011) and Lin (2011). We extend their inventory models in which the deteriorated rate is any non-negative function and backlog rate is inversely linearly related to the waiting time. Our findings will provide a new inventory system to help decision

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17

Mieg, Harald A., Stephan J. Bedenk, Anna Braun, and Franz J. Neyer. "How Emotional Stability and Openness to Experience Support Invention: A Study with German Independent Inventors." Creativity Research Journal 24, no. 2-3 (2012): 200–207. http://dx.doi.org/10.1080/10400419.2012.677341.

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18

Weick, Cynthia Wagner. "A University-Based Model for Evaluating Inventions." International Journal of Entrepreneurship and Innovation 4, no. 4 (2003): 225–35. http://dx.doi.org/10.5367/000000003129574298.

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There is a need for programmes that provide independent inventors with balanced, data-based evaluations of their early-stage ideas. These inventors do not have access to the evaluation processes used in many companies to assess whether or not an idea warrants further investment of time and resources. In addition, invention promotion services that focus on independent inventors are often costly; and some of these have been accused of fraud. The business school at the University of the Pacific (UOP) launched a pilot invention evaluation service (IES) in autumn 1999. The process used in the IES i

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19

Park, Ji Won, Barbora Piknova, Khanh Nghiem, Jay N. Lozier, and Alan N. Schechter. "Nitrite Regulation Of Platelet Reactivity Under Physiological Conditions." Blood 122, no. 21 (2013): 4739. http://dx.doi.org/10.1182/blood.v122.21.4739.4739.

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Nitric oxide (NO) is generated by serial reduction pathway of nitrate and nitrite or by activity of endogenous nitric oxide synthase (NOS), and modulates platelet function and hemostasis. We have shown by aggregometry and flow cytometric analysis of P-selectin that nitrite in the presence of erythrocytes inhibits platelet aggregation and activation after its reduction to NO at low oxygen tension [PLoS One. 2012; 7: e30380. 10.1371/journal.pone.0030380]. We then investigated how nitrite may affect overall clotting processes by regulating platelet function using thrombelastography (TEG), a metho

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20

NANCARROW, CLIVE, CELIA ATTLEE, and LEN TIU WRIGHT. "WEAKNESSES IN THE MARKETING AND THE ADOPTION OF INDEPENDENT INVENTIONS WITH IMPLICATIONS FOR INTERNATIONAL COMPETITIVENESS." Journal of Enterprising Culture 07, no. 03 (1999): 233–56. http://dx.doi.org/10.1142/s0218495899000145.

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This paper examines the peculiar entrepreneurial hiatus surrounding inventions from independent inventors in the UK which, it is argued, limits its international competitiveness. Evidence that many other countries stimulate and exploit independent inventors to a greater degree is assessed and it is concluded that the UK fails to capitalise on the innovations from this pool of talent. A programme of exploratory research is carried out to identify the reasons for this and identify lessons that have relevance to invention and innovation internationally. The research programme consists of a review

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21

Guo, Nian, and Zhongkai Xiong. "Deterring independent remanufacturers by strategic inventory." International Journal of Manufacturing Technology and Management 34, no. 6 (2020): 509. http://dx.doi.org/10.1504/ijmtm.2020.10029151.

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22

Xiong, Zhongkai, and Nian Guo. "Deterring independent remanufacturers by strategic inventory." International Journal of Manufacturing Technology and Management 34, no. 6 (2020): 509. http://dx.doi.org/10.1504/ijmtm.2020.110001.

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23

Ganguli, Ina, Jeffrey Lin, and Nicholas Reynolds. "The Paper Trail of Knowledge Spillovers: Evidence from Patent Interferences." American Economic Journal: Applied Economics 12, no. 2 (2020): 278–302. http://dx.doi.org/10.1257/app.20180017.

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We show evidence of localized knowledge spillovers using a new database of US patent interferences terminated between 1998 and 2014. Interferences resulted when two or more independent parties submitted identical claims of invention nearly simultaneously. Following the idea that inventors of identical inventions share common knowledge inputs, interferences provide a new method for measuring knowledge spillovers. Interfering inventors are 1.4 to 4.0 times more likely to live in the same local area than matched control pairs of inventors. They are also more geographically concentrated than citat

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24

Weick, Cynthia Wagner, and James D. Martin. "Full-Time and Part-Time Independent Inventors." International Journal of Entrepreneurship and Innovation 7, no. 1 (2006): 5–12. http://dx.doi.org/10.5367/000000006775870460.

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Analysis of data from a survey of independent inventors showed that part-time and full-time inventors were similar in terms of age, gender, educational level and the types of inventions they pursued. However, sales levels achieved were significantly related to the combination of a full-time commitment to inventing and a willingness to invest in patent protection. Further interviews of successful inventors indicated that the transition from part-time to full-time inventing was driven by either unexpected events, a desire to change careers, or preference for working in a more creative atmosphere

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25

Wickramasinghe, CN, N. Ahmad, and S. Rashid. "Why Independent Inventors Never Quit? In Search of Contribution of Inventive Outcomes on Subjective Success of Independent Inventors." Kelaniya Journal of Management 1, no. 1 (2014): 1. http://dx.doi.org/10.4038/kjm.v1i1.6444.

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26

Ennishi, Daisuke, Aixiang Jiang, Merrill Boyle, et al. "The Double-Hit Gene Expression Signature Defines a Clinically and Biologically Distinct Subgroup within GCB-DLBCL." Blood 132, Supplement 1 (2018): 921. http://dx.doi.org/10.1182/blood-2018-99-116827.

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Abstract Recognizing biological heterogeneity in diffuse large B-cell lymphoma (DLBCL), significant effort has been made to define distinct molecular subgroups of prognostic importance which harbor potentially targetable biology. Reflecting this, in the recent revision of the WHO classification, DLBCL was divided into cell-of-origin molecular subtypes and a new entity was defined - high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH). ~8% of tumors with DLBCL morphology are HGBL-DH/TH and all HGBL-DH/TH with BCL2 translocations (HGBL-DH/TH-BCL2) are of the GCB m

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27

Filho, Luiz Stephany, Elda Fontinele Tahim, Vitória Maria Serafim, and Cynara Barros de Moraes. "From invention to Innovation—challenges and opportunities: a multiple case study of independent inventors in Brazil and Peru." RAI Revista de Administração e Inovação 14, no. 3 (2017): 180–87. http://dx.doi.org/10.1016/j.rai.2017.05.002.

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28

Larson, Paul D., and Robert A. DeMarais. "Psychic Stock: An Independent Variable Category of Inventory." International Journal of Physical Distribution & Logistics Management 20, no. 7 (1990): 28–34. http://dx.doi.org/10.1108/eum0000000000370.

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29

Yan, Xinghao, and Hui Zhao. "Inventory sharing and coordination among n independent retailers." European Journal of Operational Research 243, no. 2 (2015): 576–87. http://dx.doi.org/10.1016/j.ejor.2014.12.033.

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30

Lin, Shih-Wei. "Inventory models with managerial policy independent of demand." European Journal of Operational Research 211, no. 3 (2011): 520–24. http://dx.doi.org/10.1016/j.ejor.2011.01.013.

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31

Nicholas, Tom. "The Role of Independent Invention in U.S. Technological Development, 1880–1930." Journal of Economic History 70, no. 1 (2010): 57–82. http://dx.doi.org/10.1017/s0022050710000057.

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Why did independent inventors account for over half of U.S. patents by 1930 and more than three times the number granted to R&D firms? Using new data on patents and historical patent citations, I show that independents supplied high-quality innovations to a geographically broad market for ideas. Those close to large urban centers developed some of the most significant technological advances. Demand for independent inventions remained high during the growth of the corporate economy as firms continued to acquire external innovations that complemented formal R&D. Despite their relative de

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32

Makhitha, K. M. "Challenges impacting on small independent retailers performance in Soweto, Johannesburg in South Africa." Investment Management and Financial Innovations 13, no. 3 (2016): 258–66. http://dx.doi.org/10.21511/imfi.13(3-1).2016.12.

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This study investigated the challenges independent retailers in Soweto, Johannesburg in South Africa face. The empirical research using a survey method was conducted among independent retailers selling different types of goods. Due to inaccessibility of a database on independent retailers in SA, a convenience sampling method was adopted for the study. Existing literature was used to design a questionnaire targeted at independent retailers to investigate the challenges that impact on their business performance. The findings of the study revealed that competition is the major challenge that inde

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33

Rachmawati, Windasari, and Vinsensia Retno Widi Wisayang. "ANALISIS PENGARUH ASSETS DAN MANAJEMEN INVENTORY TERHADAP MANAJEMEN LABA PADA PERUSAHAAN MAKANAN DAN MINUMAN YANG LISTING DI BURSA EFEK INDONESIA 2010 - 2012." Jurnal Ekonomi dan Bisnis 19, no. 1 (2018): 99. http://dx.doi.org/10.30659/ekobis.19.1.99-110.

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This research aims to learn the effect of the values of the quick ratio, turnover asset, return on aset, and inventory turnover toward net profit before taxes in the food and beverage indusry in Jakarta Stock Exchange (Indonesia) in 2012 - 2013. The approach used is qualitative approach with multiple regression. Based on the analysis described previously, it can be concluded that from the independent variable of turnoverasset, retunt on assets and inventory turnover partially have positive and significant impact on Ebit of Profit. this proves the previous studies that management of assets and

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34

Syamsuddin, Muhammad, and Trisni Suryarini. "Analisis Pengaruh Intensitas Modal, Intensitas Persediaan, Komisaris Independen dan Kepemilikan Manajerial Terhadap ETR." Jurnal Penelitan Ekonomi dan Bisnis 5, no. 1 (2020): 52–65. http://dx.doi.org/10.33633/jpeb.v5i1.2707.

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This study aims to analyze the effect of capital intensity, inventory intensity, independent board of commissioners and managerial ownership on the effective tax rate. The population in this study are manufacturing companies listed on the Indonesia Stock Exchange (IDX) in 2015-2017. The sample selection uses the purposive sampling method. The results of the sample selection obtained a final sample of 75 companies with an analysis unit of 225. The data analysis of this study used descriptive statistical analysis and Structural Analysis Modeling (SEM) with AMOS 22 software. The results showed th

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35

Maurer, Stephen M., and Suzanne Scotchmer. "The Independent Invention Defence in Intellectual Property." Economica 69, no. 276 (2002): 535–47. http://dx.doi.org/10.1111/1468-0335.00299.

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36

Alpern, Stanley B. "Did They or Didn't They Invent It? Iron in Sub-Saharan Africa." History in Africa 32 (2005): 41–94. http://dx.doi.org/10.1353/hia.2005.0003.

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Judging from a number of recent publications, the long-running debate over the origins of iron smelting in sub-Saharan Africa has been resolved… in favor of those advocating independent invention. For Gérard Quéchon, the French archeologist to whom we owe very early dates for iron metallurgy from the Termit Massif in Niger, “indisputably, in the present state of knowledge, the hypothesis of an autochthonous invention is convincing.” According to Eric Huysecom, a Belgian-born archeologist, “[o]ur present knowledge allows us … to envisage one or several independent centres of metal innovation in

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37

Hintz, Eric S. "The Post-Heroic Generation: American Independent Inventors, 1900–1950." Enterprise & Society 12, no. 4 (2011): 732–48. http://dx.doi.org/10.1017/s146722270001065x.

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By World War I, the public (and later, many historians) had come to believe that teams of anonymous scientists in corporate research and development (R&D) laboratories had displaced “heroic” individual inventors like Thomas Edison and Alexander Graham Bell as the wellspring of innovation. However, the first half of the twentieth century was actually a long transitional period when lesser known independents like Chester Carlson (Xerox copier), Earl Tupper (Tupperware), Samuel Ruben (Duracell batteries), and Edwin Land (Polaroid camera) continued to make notable contributions to the overall

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38

Fleischmann, Moritz, and Roelof Kuik. "On optimal inventory control with independent stochastic item returns." European Journal of Operational Research 151, no. 1 (2003): 25–37. http://dx.doi.org/10.1016/s0377-2217(02)00592-1.

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39

Hintz, E. S. "The Post-Heroic Generation: American Independent Inventors, 1900-1950." Enterprise and Society 12, no. 4 (2011): 732–48. http://dx.doi.org/10.1093/es/khr039.

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40

Puranam, Kartikeya, David C. Novak, Marilyn T. Lucas, and Mark Fung. "Managing blood inventory with multiple independent sources of supply." European Journal of Operational Research 259, no. 2 (2017): 500–511. http://dx.doi.org/10.1016/j.ejor.2016.11.005.

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41

Farinha, Pedro, Daisuke Ennishi, Anja Mottok, et al. "TP53 Expression Correlates with TP53 Mutations and Is an Independent Predictor of Clinical Outcome in Patients with DLBCL Treated with R-CHOP." Blood 134, Supplement_1 (2019): 3964. http://dx.doi.org/10.1182/blood-2019-121943.

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Background: Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous neoplasm with 40% of patients experiencing treatment failure following immuno-chemotherapy (R-CHOP). Both cell-of-origin (COO) and presence of concurrent MYC/BCL2 rearrangements (DHIT) are significantly associated with distinct inferior outcome. Recently, next-generation sequencing (NGS) studies have uncovered distinct genetic subtypes, including a sizable ABC/GCB-independent group characterized by more frequent TP53 abnormalities. The patterns of TP53 mutations and the prognostic significance in DLBCL have been previo

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42

Eide, Christopher A., Daniel Bottomly, Samantha L. Savage, et al. "Characterization of the Genomic Landscape of BCR-ABL1 Kinase-Independent Mechanisms of Resistance to ABL1 Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia." Blood 128, no. 22 (2016): 1119. http://dx.doi.org/10.1182/blood.v128.22.1119.1119.

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Abstract Despite the well-established success of ABL1 tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukemia (CML), approximately 20% of patients treated with frontline imatinib develop resistance by 5 years on therapy. The majority (~60%) of such resistant cases are explained by acquired mutations within the BCR-ABL1 kinase domain that compromise inhibitor binding, and nearly all of these mutations are effectively targeted by one or more of the 2nd and 3rd generation ABL1 kinase inhibitors. In contrast, the remaining ~40% of imatinib-resistant cases harbo

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43

Randall, Tom M. "Paranormal Short Inventory." Perceptual and Motor Skills 84, no. 3_suppl (1997): 1265–66. http://dx.doi.org/10.2466/pms.1997.84.3c.1265.

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A short, 13–item supernatural belief scale was created from an established longer version. The new scale showed good reliability. Validation was provided with a correlation of .86 with an independent scale of supernatural belief. Women scored significantly higher than men.

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44

Vermorken, J. B., J. Stöhlmacher, I. Davidenko, et al. "An analysis of safety in patients (pts) with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) receiving chemotherapy (CT) with or without panitumumab (pmab) in a phase III clinical trial (SPECTRUM)." Journal of Clinical Oncology 27, no. 15_suppl (2009): 6050. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6050.

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6050^ Background: The epidermal growth factor receptor (EGFR) is an important target for treatment of patients with SCCHN. Pmab is a fully human monoclonal antibody against EGFR. This study is planned to assess the safety and efficacy of pmab in combination with a standard platinum-based CT regimen for patients with R/M disease. Methods: This ongoing, global, phase III, open-label, randomized (1:1) study is enrolling pts with R/M SCCHN. Pts receive cisplatin 100 mg/m2 IV on day 1 plus 5-FU (1,000 mg/m2) continuous IV daily on days 1–4 ± pmab (9 mg/kg on day 1) every 21 days for up to 6 cycles.

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45

Dong, Hailing, and Guochao Jiang. "Limit Distribution of Inventory Level of Perishable Inventory Model." Mathematical Problems in Engineering 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/329531.

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This paper studies a perishable inventory model, which assumes that each perishable item has finite lifetime, and only one item is consumed each time. The lifetimes of perishable items are independent random variables with the general distribution and so are the consumption internal. Under this assumption, by using backward equations and limit distribution of Markov skeleton processes, this paper obtains the existence conditions and the explicit expression of the limit distribution of the inventory level of perishable inventory model.

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46

Jimenez, Mona. "Community Archiving Independent Media." KULA: Knowledge Creation, Dissemination, and Preservation Studies 2 (November 29, 2018): 15. http://dx.doi.org/10.5334/kula.31.

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Collections of independent, non-commercial works often represent voices and speak to topics not seen in mainstream media, and they are still often cared for outside of major collecting institutions. Since 2011, activist audiovisual archivists have organized Community Archiving Workshops (CAWs) in the US and beyond to help caretakers of endangered media and film collections jump-start preservation efforts. In the spirit of ‘each one, teach one,’ experienced archivists share skills with other volunteers to inspect and inventory a collection, thus giving caretakers the data they need to select pr

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Maxson, Julia Elizabeth, Abel L. Melissa, Jinhua Wang, et al. "Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations." Blood 124, no. 21 (2014): 435. http://dx.doi.org/10.1182/blood.v124.21.435.435.

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Abstract BACKGROUND: A tremendous amount of information now exists detailing the genetic alterations present in leukemia cells. However, our understanding of the functional significance of many of these genetic events remains incomplete. One major challenge involves the identification of pharmacologically targetable mutations for the design and implementation of targeted therapy strategies. To this end, we are using an algorithm called HitWalker (Bottomly, et al. 2013), which can prioritize gene mutations based on functional data, thus revealing the pharmacologic vulnerabilities of leukemia ce

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Mungan, Murat C. "Economics of the Independent Invention Defense under Incomplete Information." Supreme Court Economic Review 20, no. 1 (2012): 183–203. http://dx.doi.org/10.1086/668519.

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Murray, John M. "Development and Psychometric Evaluation of the Independent School Teacher Development Inventory." Journal of Experimental Education 80, no. 3 (2012): 219–45. http://dx.doi.org/10.1080/00220973.2012.672346.

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Åstebro, Thomas. "Basic Statistics on the Success Rate and Profits for Independent Inventors." Entrepreneurship Theory and Practice 23, no. 2 (1998): 41–48. http://dx.doi.org/10.1177/104225879802300203.

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