Relevant bibliographies by topics / Indinavir drug

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Academic literature on the topic 'Indinavir drug'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "Indinavir drug"

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D. V. R. N., Bhikshapathi, Shiva Krishna A, Ramesh M, Suresh G, and Jyothi Sri S. "Erythrocytes as Carriers of Indinavir: Preparation, Characterization, In vitro and In vivo Pharmacokinetic Evaluation in Rats." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 1 (2017): 3573–81. http://dx.doi.org/10.37285/ijpsn.2017.10.1.2.

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Indinavir is a protease inhibitor of the human immuno-deficiency virus. Indinavir is commercially available as capsule of 200 mg and 400 mg. Adult dose is 800 mg every 8 h. i.e., 2400 mg per day is equivalent to 6 capsules per day. No other dosage form is available in the market. Sustained release dosage form of indinavir can produce maximum therapeutic effect with minimum side effects and achieve better patient compliance. Various carriers have been used for the drug targeting among which cellular carriers such as erythrocytes offer greater potential advantages than other system. The drug is
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Hugen, Patricia WH, David M. Burger, Kees Brinkman, et al. "Carbamazepine–Indinavir Interaction Causes Antiretroviral Therapy Failure." Annals of Pharmacotherapy 34, no. 4 (2000): 465–70. http://dx.doi.org/10.1345/aph.19211.

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OBJECTIVE: To report a case of antiretroviral therapy failure caused by an interaction between carbamazepine and indinavir. CASE SUMMARY: A 48-year-old HIV-positive white man was treated with antiretroviral triple therapy, consisting of indinavir, zidovudine, and lamivudine. His HIV-RNA (viral load) became undetectable (<400 copies/mL) less than two months after this therapy was started; this was confirmed one month later. Shortly after the start of antiretroviral therapy, the patient developed herpes zoster, which was treated with famciclovir. Tramadol was initially prescribed for postherp
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Haas, David W., Benjamin Johnson, Janet Nicotera, et al. "Effects of Ritonavir on Indinavir Pharmacokinetics in Cerebrospinal Fluid and Plasma." Antimicrobial Agents and Chemotherapy 47, no. 7 (2003): 2131–37. http://dx.doi.org/10.1128/aac.47.7.2131-2137.2003.

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ABSTRACT Therapeutic control of human immunodeficiency virus type 1 (HIV-1) in peripheral compartments does not assure control in the central nervous system. Inadequate drug penetration may provide a sanctuary from which resistant virus can emerge or allow development of psychomotor abnormalities. To characterize the effect of ritonavir on indinavir disposition into cerebrospinal fluid, seven HIV-infected adults underwent intensive sampling at steady-state while receiving twice-daily indinavir (800 mg) and ritonavir (100 mg). Serial cerebrospinal fluid and plasma samples were obtained at 10 ti
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Kharasch, Evan D., Christine Hoffer, Dale Whittington, Alysa Walker, and Pamela Sheffels Bedynek. "Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport." Anesthesiology 110, no. 3 (2009): 660–72. http://dx.doi.org/10.1097/aln.0b013e3181986a9a.

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Background Methadone clearance is highly variable, and drug interactions are problematic. Both have been attributed to CYP3A, but actual mechanisms are unknown. Drug interactions can provide such mechanistic information. Ritonavir/indinavir, one of the earliest protease inhibitor combinations, may inhibit CYP3A. We assessed ritonavir/indinavir effects on methadone pharmacokinetics and pharmacodynamics, intestinal and hepatic CYP3A activity, and intestinal transporters (P-glycoprotein) activity. CYP3A and transporters were assessed with alfentanil and fexofenadine, respectively. Methods Twelve
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T, Rajkumar, Sivasanker Reddy L, Sivasanker Reddy L, Rajeswari V, and Rajeswari V. "SYNTHESIS AND CHARACTERIZATION OF INDINAVIR-Cu COMPLEX." Asian Journal of Pharmaceutical and Clinical Research 10, no. 7 (2017): 289. http://dx.doi.org/10.22159/ajpcr.2017.v10i7.15359.

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Objective: The main objective of the present work is to synthesize Cu (II) indinavir, complex.Methods: The indinavir complexes were discussed with the help of spectroscopic instrumental methods such as infrared, ultraviolet, nuclear magnetic resonance, and mass and titrimetry methods (iodometry and potentiometry). Drug and drug metal complex are screened against antimicrobial activity.Results: The spectral studies show that the metal is coordinated to the drug in a bidentate manner. The titrimetry method, i.e., iodometric titration shows that metal bind to the drug in proportion of 1:1. The po
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Kharasch, Evan D., Pamela Sheffels Bedynek, Christine Hoffer, Alysa Walker, and Dale Whittington. "Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A)." Anesthesiology 116, no. 2 (2012): 432–47. http://dx.doi.org/10.1097/aln.0b013e3182423478.

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Background Methadone disposition and pharmacodynamics are highly susceptible to interactions with antiretroviral drugs. Methadone clearance and drug interactions have been attributed to cytochrome P4503A4 (CYP3A4), but actual mechanisms are unknown. Drug interactions can be clinically and mechanistically informative. This investigation assessed effects of the protease inhibitor indinavir on methadone pharmacokinetics and pharmacodynamics, hepatic and intestinal CYP3A4/5 activity (using alfentanil), and intestinal transporter activity (using fexofenadine). Methods Twelve healthy volunteers unde
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De Wit, S., M. Debier, M. De Smet, et al. "Effect of Fluconazole on Indinavir Pharmacokinetics in Human Immunodeficiency Virus-Infected Patients." Antimicrobial Agents and Chemotherapy 42, no. 2 (1998): 223–27. http://dx.doi.org/10.1128/aac.42.2.223.

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ABSTRACT To evaluate a potential pharmacokinetic interaction of coadministration of fluconazole, and indinavir, a human immunodeficiency virus (HIV) protease inhibitor, 13 patients were enrolled in a multiple-dose, three-period, placebo-controlled, crossover study. Patients were randomly assigned to receive indinavir at 1,000 mg every 8 h for 7 1 3 days (with fluconazole placebo), fluconazole at 400 mg once daily for 8 days (with indinavir placebo), and indinavir with fluconazole in combination. The pharmacokinetics of both drugs were measured on day 8 of each treatment period. The peak concen
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Bergshoeff, A. S., P. L. A. Fraaij, A. M. C. van Rossum, et al. "Pharmacokinetics of Indinavir Combined with Low-Dose Ritonavir in Human Immunodeficiency Virus Type 1-Infected Children." Antimicrobial Agents and Chemotherapy 48, no. 5 (2004): 1904–7. http://dx.doi.org/10.1128/aac.48.5.1904-1907.2004.

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ABSTRACT So far, no pediatric doses for indinavir combined with ritonavir have been defined. This study evaluated the pharmacokinetics of 400 mg of indinavir/m2 combined with 125 mg of ritonavir/m2 every 12 h (q12h) in 14 human immunodeficiency virus type 1-infected children. The area under the concentration-time curve from 0 to 24 h and the minimum concentration of drug in serum for indinavir were similar to those for 800 mg of indinavir-100 mg of ritonavir q12h in adults, while the maximum concentration of drug in serum was slightly decreased, with geometric mean ratios (90% confidence inter
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Ross, Natasha, Nicolette Hendricks-Leukes, Rachel Fanelwa Ajayi, Priscilla Baker, and Emmanuel I. Iwuoha. "Conductive Composite Biosensor System for Electrochemical Indinavir Drug Detection." Journal of Chemistry 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/630408.

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Indinavir is a protease inhibitor antiretroviral (ARV) drug, which forms part of the highly active antiretroviral therapy during the treatment of HIV/AIDS. Indinavir undergoes first-pass metabolism through the cytochrome P450 (CYP) enzymes in the human liver, of which CYP3A4 is the most influential isoenzyme. Multidrug combination therapy and, as such, therapeutic drug monitoring (TDM) during HIV/AIDS treatment are therefore critical, to prevent adverse interactions. The conventional sensitive and specific assays available for quantifying ARV drugs, however, suffer from distinct disadvantages.
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Snyder, Stuart, D. Z. D'Argenio, Owen Weislow, John A. Bilello, and G. L. Drusano. "The Triple Combination Indinavir-Zidovudine-Lamivudine Is Highly Synergistic." Antimicrobial Agents and Chemotherapy 44, no. 4 (2000): 1051–58. http://dx.doi.org/10.1128/aac.44.4.1051-1058.2000.

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ABSTRACT Administration of the combination of indinavir-zidovudine-lamivudine has been demonstrated to cause a large fraction of treated patients to have a decline in human immunodeficiency virus type 1 (HIV-1) copy number to below the detectability of sensitive assays. A recent investigation (G. L. Drusano, J. A. Bilello, D. S. Stein, M. Nessly, A. Meibohm, E. A. Emini, P. Deutsch, J. Condra, J. Chodakewitz, and D. J. Holder, J. Infect. Dis. 178:360–367, 1998) demonstrated that the durability of the antiviral effect was affected by combination chemotherapy. Zidovudine-lamivudine-indinavir dif
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Dissertations / Theses on the topic "Indinavir drug"

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Liu, Fengling. "Kinetic and Crystallographic Studies of Drug-Resistant Mutants of HIV-1 Protease: Insights into the Drug Resistance Mechanisms." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/biology_diss/19.

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HIV-1 protease (PR) inhibitors (PIs) are important anti-HIV drugs for the treatment of AIDS and have shown great success in reducing mortality and prolonging the life of HIV-infected individuals. However, the rapid development of drug resistance is one of the major factors causing the reduced effectiveness of PIs. Consequently, various drug resistant mutants of HIV-1 PR have been extensively studied to gain insight into the mechanisms of drug resistance. In this study, the crystal structures, dimer stabilities, and kinetics data have been analyzed for wild type PR and over 10 resistant mutants
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Eira, Margareth da. "\"Alterações na função renal em pacientes HIV/AIDS tratados com esquemas terapêuticos incluindo indinavir\"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-10052005-150439/.

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Complicações renais e urológicas incluindo nefrolitíase, cristalúria, cólica renal e lombalgia, são eventos adversos bem conhecidos do indinavir (IDV), um inibidor de protease (IP) largamente utilizado no tratamento de pacientes infectados com o vírus da imunodeficiência humana (HIV). Prévios estudos em ratos demonstraram que o IDV, um potente IP capaz de provocar uma sustentada supressão da carga viral do HIV, induz vasoconstricção renal, diminui a filtração glomerular (RFG) e reduz a excreção urinária de nitrito (NO2-), sugerindo que a vasoconstricção causada pelo IDV deve ser mediada pelo ó
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Kim, Dong Hyun. "Investigation of HIV anti-viral drug effect on HPV16 E6 expressing cervical carcinoma cells using advanced metabolomics methods." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-hiv-antiviral-drug-effect-on-hpv16-e6-expressing-cervical-carcinoma-cells-using-advanced-metabolomics-methods(d52b3b66-2a7b-4577-a334-b74bc12b27cc).html.

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Metabolomics approaches have recently been used to understand the complex molecular interactions of biological systems. One popular area in which these methods are being developed is to understand the biochemical changes during abiotic and biotic stresses; for example, how a cell may respond to a drug. Since metabolites are the end products of gene expression, these can be used to indicate the result of the activities and interaction of the cell or organism with its environment. The investigation of the level and compositional changes of metabolites against metabolic stresses such as chemother
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Feleni, Usisipho. "Quantum dots-amplified electrochemical cytochrome P450 phenotype sensor for tamoxifen, a breast cancer drug." University of the Western Cape, 2017. http://hdl.handle.net/11394/5505.

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Philosophiae Doctor - PhD<br>Breast cancer is regarded as the most common cancer in South Africa and its rate of occurrence is increasing. About one in every 31 South African women are at the risk of developing breast cancer and early diagnosis and treatment guarantee 90% survival rate. Tamoxifen is the drugs of choice for the treatment of all stages of breast cancer. The drug binds with estrogen receptor (ER) to minimize the transcription of estrogen dependent genes. However, nearly 50% of ER-positive breast cancer patients either become resistant or fail to respond to tamoxifen resulti
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Feleni, Usisipho. "Palladium telluride quantum dots biosensor for the determination of indinavir drug." 2013. http://hdl.handle.net/11394/3504.

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Magister Scientiae - MSc<br>Indinavir is a potent and well tolerated protease inhibitor drug used as a component of the highly active antiretroviral therapy (HAART) of HIV/AIDS, which results in pharmacokinetics that may be favourable or adverse. These drugs work by maintaining a plasma concentration that is sufficient to inhibit viral replication and thereby suppressing a patient’s viral load. A number of antiretroviral drugs, including indinavir, undergo metabolism that is catalysed by cytochrome P450-3A4 enzyme found in the human liver microsomes. The rate of drug metabolism influences a pa
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Arnold, Christof Karric, and 安珂. "Herb-drug interaction of Radix Scutellariae herbal extract powder and indinavir in Sprague-Dawley rats." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/21429358066086009397.

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碩士<br>國立陽明大學<br>傳統醫藥研究所<br>98<br>The integration of traditional Chinese medicine into a modern context poses certain difficulties. Pharmacological mechanisms developed in the field of science can be used as a tool to examine the properties of medicinal herbs. Identifiable small molecules help to provide some outline of a medicinal herb’s characteristics. The root, known as Radix Scutellariae (黃芩) which is an herb appearing in the oldest known Han records on medicinal substances, is chosen for this investigation due to its properties of CYP450 3A enzyme inhibition. The human immunodeficiency vi
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Hendricks, Nicolette Rebecca. "Electrochemical dynamics of cytochrome p450-3a4 isoenzyme biosensor for protease inhibitor antiretroviral drug." Thesis, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_3467_1361368134.

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<p>The highly active antiretroviral therapy (HAART) drug agent, indinavir, and the endocrine disruptor compound, 2,4-dichlorophenol (2,4-DCP), are directly related to two of South Africa&rsquo<br>s, and in fact, two of the globe&rsquo<br>s most fundamentally important and comprehensively researched subjects areas, which includes, HIV/AIDS and water pollution. In fact&nbsp<br>these two compounds share multiple significant commonality factors. Firstly, they have a profound effect on the health aspects of humans, albeit from opposite sides of the&nbsp<br>&lsquo<br>equation&rsquo<br>. Secondly, in
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Calitz, Carlemi. "Impact of selected herbal products on intestinal epithelial permeation and metabolism of indinavir / Carlemi Calitz." Thesis, 2014. http://hdl.handle.net/10394/14481.

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Patients on anti-retroviral (ARV) drug treatment are sometimes simultaneously taking other prescribed drugs and/or over-the-counter drugs and/or herbal remedies. Pharmacokinetic drug-drug or herb-drug interactions can occur in these patients, which might be synergistic or antagonistic in nature leading to increased or decreased bioavailability of the ARV. Consequences of bioavailability changes may either be adverse effects due to increased plasma levels, or lack of pharmacological responses due to decreased plasma levels. The aim of this study is to determine if pharmacokinetic interactions e
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Huang, Da-Kong, and 黃大剛. "Simultaneous Determination of Three HIV Protease Inhibitors in Plasma and Drug Interactions between St. John''s wort and Indinavir in Rats." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/55820520161330001110.

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碩士<br>國立臺灣大學<br>藥學研究所<br>93<br>英文摘要 St. John’s wort (Hypericum perforatum, SJW) is one of the most popular herbal preparations widely used in the treatment of mild to moderate depression. However, a series of case reports and clinical studies indicate SJW play a role in drug interactions. In some clinical observations, SJW can reduce the plasma concentration of indinavir, a HIV protease inhibitor. In our study, an animal model for the investigation of the herb-drug interactions between SJW and indinavir has been established. By optimizing pH value and acetonitrile content of the mobile ph
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Books on the topic "Indinavir drug"

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Turney, Ben, and John Reynard. Kidney stones. Edited by John Reynard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0013.

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The composition of kidney stones is variable and the predisposing factors multifactorial. Consequently, a detailed evaluation of the patient’s lifestyle, diet, fluid intake, medical history, drug history, urinary tract anatomy, blood, and urine biochemistry and stone composition is required determine predisposing factors for stone formation in an individual patient. Combinatorial subtle variants in biochemistry may act synergistically to increase risk of stone formation/recurrence. Many medications may alter blood and/or urine biochemistry and predispose to stone formation. Corticosteroids inc
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Book chapters on the topic "Indinavir drug"

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Ghosh, Arun K., and Sandra Gemma. "HIV-1 Protease Inhibitors for the Treatment of HIV Infection and AIDS: Design of Saquinavir, Indinavir, and Darunavir." In Structure-Based Design of Drugs and Other Bioactive Molecules. Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527665211.ch11.

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"Indinavir." In PharmacotherapyFirst Drug Information. The American Pharmacists Association, 2017. http://dx.doi.org/10.21019/druginformation.indinavir.

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"Indinavir." In Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Elsevier, 2006. http://dx.doi.org/10.1016/b0-44-451005-2/00765-8.

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Johnson, Bruce D., Angela Howard, Richard Varsolona, James McCauley, and Dean K. Ellison. "Indinavir Sulfate." In Analytical Profiles of Drug Substances and Excipients. Elsevier, 1999. http://dx.doi.org/10.1016/s0099-5428(08)60626-7.

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Bartlett, John G., Robert R. Redfield, and Paul A. Pham. "Drug Information." In Bartlett's Medical Management of HIV Infection. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190924775.003.0006.

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Abstract: This chapter is about pharmacology, side effects, and drug interactions of various drugs, including abacavir (ABC), acyclovir, Amphotericin B, atazanavir (ATV), atorvastatin, atovaquone, azithromycin, azoles, bedaquiline, bictegravir (BIC), bupropion, buspirone, caspofungin, cidofovir, ciprofloxacin, clarithromycin, clindamycin, clotrimazole, cobicistat (COBI), dapsone, darunavir (DRV), daunorubicin citrate liposome, didanosine (ddI), dolutegravir (DTG), doxycycline, efavirenz (EFV), emtricitabine (FTC), elvitegravir (EVG), enfuvirtide (T-20), entecavir, erythropoietin, ethambutol, etravirine (ETR), fentanyl, fluconazole, flucytosine, fluoxetine, fosamprenavir (FPV), ibalizumab-uiyk (Trogarzo), indinavir (IDV), itraconazole, lamivudine (3TC), leucovorin, lopinavir/ritonavir (LPV/r), maraviroc (MVC), methadone, nelfinavir (NFP), nevirapine (NVP), oxandrolone, paromomycin, pegylated interferon, pentamidine, pravastatin, pyrazinamide, pyrimethamine, raltegravir (RAL), ribavirin, rifabutin, rifampin, rilpivirine (RPV), ritonavir (RTV), saquinavir (SQV), stavudine (d4T), sulfadiazine, tenofovir (TDF and TAF), testosterone, thalidomide, tipranavir (TPV), trazodone, trimethoprim, trimethoprim-sulfamethoxazole, voriconazole,zidovudine, and Hep C antiviral agents.
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Cordes, Eugene H. "HIV protease inhibitors: weapons in the war against HIV/AIDS." In Hallelujah Moments. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190080457.003.0004.

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The discovery of drugs for AIDS has converted these infections from a death sentence into a chronic infectious disease. The research of Luc Montagnier and Robert Gallo established that HIV is the cause of AIDS, subsequently known as HIV/AIDS, the most deadly infective disease known. Basic research into the life cycle of HIV revealed a number of potential molecular targets for treatment of the infection. Among these are HIV protease and reverse transcriptase, enzymes required for the propagation of the virus in human T cells. AZT (azidothymidine), a reverse transcriptase inhibitor, was the first drug approved for treatment of HIV/AIDS. It was followed by three HIV protease inhibitors: saquinavir, ritonavir, and indinavir (Incivek). The last of these was discovered through a structure-based drug design strategy and proved to be a turning point in therapy for HIV/AIDS. This drug discovery effort was conducted in an atmosphere of prejudice, ignorance, snake oil medicine, and intense activism by Act Up and others. The net result is a miracle of modern medicine.
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"Indinavir." In Meyler's Side Effects of Drugs. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-444-53717-1.00886-6.

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