Academic literature on the topic 'Indole-3-carboxaldehyde'

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Journal articles on the topic "Indole-3-carboxaldehyde"

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Kemp, Chesley A., Donna K. McCullough, Dobrusia Bialonska, and Paul J. T. Johnson. "Effect of Bromination on the Quorum Sensing-Inhibiting Properties of Indole-3-Carboxaldehydes in Chromobacterium violaceum AHL System." Microbiology Research 12, no. 2 (2021): 376–82. http://dx.doi.org/10.3390/microbiolres12020025.

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Quorum sensing (QS) is a form of bacterial communication involved in the production of virulence factors in many species. As a result, inhibition of quorum sensing may be of use in mitigating pathogenesis. The signaling molecule indole is currently being investigated as a target for quorum sensing inhibition (QSI) and the indole derivative indole-3-carboxaldehyde (ICA) has been shown to inhibit quorum sensing-mediated behaviors in Escherichia coli. In this study, we investigate bromination as a method of increasing the QSI capabilities of indole carboxaldehydes. The IC50 values of three monobr
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Wang, Li, Xin Guo, and Lirong Han. "Effects and Inhibition Mechanism of Indole-3-Carboxaldehyde in Controlling Scutellaria baicalensis Root Rot." Horticulturae 11, no. 3 (2025): 263. https://doi.org/10.3390/horticulturae11030263.

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Scutellaria baicalensis Gorg is a medicinal herb of significant value in traditional Chinese medicine. Root rot is a major issue in S. baicalensis-producing areas. The aim of this study was to evaluate whether indole-3-carboxaldehyde, a metabolite derived from Purpureocillium lilacinum, has a significant effect on Fusarium solani (one of the main pathogenic fungi causing S. baicalensis root rot), and to clarify its antifungal mechanism. We evaluated the toxicity of indole-3-carboxaldehyde to F. solani using the growth rate assay and found that the EC50 value was 59.563 μg/mL; we also performed
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Rao, A. R. Balavardhana, and Samudranil Pal. "Cyclopalladation of indole-3-carboxaldehyde aroylhydrazones." Journal of Organometallic Chemistry 696, no. 13 (2011): 2660–64. http://dx.doi.org/10.1016/j.jorganchem.2011.03.033.

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Naskar, Subhendu, Abhijit Hazra, Priyankar Paira, Krishnendu B. Sahu, Sukdeb Banerjee, and Nirup B. Mondal. "NH4Cl-Promoted Synthesis of Symmetrical and Unsymmetrical Triindolylmethanes Under Solvent-Free Conditions." Journal of Chemical Research 2008, no. 10 (2008): 568–71. http://dx.doi.org/10.3184/030823408x361101.

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The synthesis of various triindolylmethanes from indole-3-carboxaldehyde, using indole derivatives as reactants and NH4Cl as catalyst under solvent-free conditions, is described. This methodology provides access to both symmetrical and unsymmetrical triindolylmethanes in excellent yields. With N-methylindole particularly, indole-3-carboxaldehyde appears to act as a formyl donor, leading to the exclusive formation of a symmetrically trisubstituted product. The novelty of the methodology lies in its operational simplicity, environment friendly reaction conditions, and inexpensive and easy availa
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Wang, Jieqiong, Weifeng Yan, Xu Cheng, Yonggang Tong, Sihong Wang, and Chunmei Jin. "The Intestinal Barrier Protective Effect of Indole Aldehyde Derivatives on Acute Toxoplasma gondii Infection." Molecules 29, no. 21 (2024): 5024. http://dx.doi.org/10.3390/molecules29215024.

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Toxoplasmosis, a zoonotic infection caused by Toxoplasma gondii (T. gondii), poses a significant risk to human health and public safety. Despite the availability of clinical treatments, none effectively mitigate the intestinal barrier damage, which is the primary defense against T. gondii invasion. This study introduced aldehyde groups into the indole scaffold of a peptide-like structure to investigate the protective effects of these indole aldehyde derivatives on the intestinal barrier in mice with acute T. gondii infection. This approach leveraged the propensity of peptides and aldehyde grou
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Lakshmi Reddy, Vanammoole, Parvathaneni Sai Prathima, Vaidya Jayathirtha Rao, and Raktani Bikshapathi. "An efficient synthesis of versatile synthon 3-chlorooxindoles with NaCl/oxone." New Journal of Chemistry 42, no. 24 (2018): 20152–55. http://dx.doi.org/10.1039/c8nj04855j.

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Morteza, Shiri, and Bozorgpour‑Savadjani Zahra. "Highly selective base-catalyzed ring closing Ugi-adducts from the reaction of 2-formylindole, 2-bromoacetic acid, amines and isocyanides." Journal of the Iranian Chemical Society 12, no. 3 (2014): 389–96. https://doi.org/10.1007/s13738-014-0495-6.

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The intermediate products of the Ugi reaction between indole-2-carboxaldehyde, 2bromoacetic acid, amines and isocyanides were treated with Cs2CO3 in DMF to form a series of novel cyclized 1,2-dihydropyrazino[1,2a]indol-3(4H)-ones (indole –NH cyclization) as major and piperazin-2-ones (amide –NH cyclization) as minor products.
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Liu, Xiang-Hong, Feng-Ping Miao, Xiao-Dong Li, Xiu-Li Yin, and Nai-Yun Ji. "A New Sesquiterpene from an Endophytic Aspergillus versicolor Strain." Natural Product Communications 7, no. 7 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700702.

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A new sesquiterpene, albican-11,14-diol (1), and seven known compounds, including sterigmatocystin (2), 3-hydroxy-5-(hydroxymethyl)-4-(4′-hydroxyphenoxy) pyrrolidin-2-one (3), (1 H-indol-3-yl) oxoacetamide (4), indole-3-carboxylic acid (5), indole-3-acetic acid (6), indole-3-carboxaldehyde (7), and volemolide (8), were isolated from the cultures of Aspergillus versicolor, an endophytic fungus isolated from the marine green alga Codium fragile. The structure of 1 was elucidated by 1D, 2D NMR and mass spectroscopic techniques. The bioassay results showed that 1 possessed potent activity against
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Gómez-Betancur, Isabel, Jianping Zhao, Lin Tan, et al. "Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities." Marine Drugs 17, no. 7 (2019): 401. http://dx.doi.org/10.3390/md17070401.

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Marine organisms are recognized as a source of compounds with interesting biological activities. Vibrio neocaledonicus has been reported on for its high effectiveness against corrosion in metals but it has been little studied for its chemical and biological activities. In this study, four compounds were isolated from V. neocaledonicus: indole (1); 1H-indole-3-carboxaldehyde (2); 4-hydroxybenzaldehyde (3) and Cyclo (-Pro-Tyr) (4); using a bioassay-guided method, since in a previous study it was found that the ethyl acetate extract was active on the enzymes acetylcholinesterase (AChE), alpha-glu
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Shatova, O. P., A. V. Shestopalov, E. Yu Zlatnik, I. A. Novikova, A. S. Goncharova, and A. Yu Maksimov. "The effect of fecal microbiota transplantation on levels of tryptophan metabolites in intestine and serum of gnotobiotic mice." Biomeditsinskaya Khimiya 71, no. 3 (2025): 209–16. https://doi.org/10.18097/pbmcr1554.

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Gut microbiota is one of the key suppliers of tryptophan metabolites, which perform various functions in the host organism, including their role as signaling molecules. Fecal microbiota transplantation (FMT) is widely used as a method for determining the contribution of microorganisms to the content of various metabolites in the holoorganism. In this regard, the aim of our study was to investigate the effect of FMT on the level of tryptophan metabolites in feces and blood in gnotobiotic mice. It was found that both before and after FMT, indole-3-lactate, and quinolinic acid were the dominant t
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Conference papers on the topic "Indole-3-carboxaldehyde"

1

Premkumar, R., R. Mohamed Asath, T. Mathavan, and A. Milton Franklin Benial. "Structural, vibrational spectroscopic and quantum chemical studies on indole-3-carboxaldehyde." In DAE SOLID STATE PHYSICS SYMPOSIUM 2016. Author(s), 2017. http://dx.doi.org/10.1063/1.4980823.

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Jabbar, Alyaa, and Yasameen K. Al-Majedy. "Synthesis and bio-evaluation of 2-Methyl Indole-3-carboxaldehyde derivatives as potential lanosterol 14-demethylase inhibitors." In 4TH INTERNATIONAL CONFERENCE ON INNOVATION IN IOT, ROBOTICS AND AUTOMATION (IIRA 4.0). AIP Publishing, 2025. https://doi.org/10.1063/5.0255335.

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