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Journal articles on the topic 'Indole-3-carboxaldehyde'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Kemp, Chesley A., Donna K. McCullough, Dobrusia Bialonska, and Paul J. T. Johnson. "Effect of Bromination on the Quorum Sensing-Inhibiting Properties of Indole-3-Carboxaldehydes in Chromobacterium violaceum AHL System." Microbiology Research 12, no. 2 (2021): 376–82. http://dx.doi.org/10.3390/microbiolres12020025.

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Quorum sensing (QS) is a form of bacterial communication involved in the production of virulence factors in many species. As a result, inhibition of quorum sensing may be of use in mitigating pathogenesis. The signaling molecule indole is currently being investigated as a target for quorum sensing inhibition (QSI) and the indole derivative indole-3-carboxaldehyde (ICA) has been shown to inhibit quorum sensing-mediated behaviors in Escherichia coli. In this study, we investigate bromination as a method of increasing the QSI capabilities of indole carboxaldehydes. The IC50 values of three monobr

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2

Wang, Li, Xin Guo, and Lirong Han. "Effects and Inhibition Mechanism of Indole-3-Carboxaldehyde in Controlling Scutellaria baicalensis Root Rot." Horticulturae 11, no. 3 (2025): 263. https://doi.org/10.3390/horticulturae11030263.

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Scutellaria baicalensis Gorg is a medicinal herb of significant value in traditional Chinese medicine. Root rot is a major issue in S. baicalensis-producing areas. The aim of this study was to evaluate whether indole-3-carboxaldehyde, a metabolite derived from Purpureocillium lilacinum, has a significant effect on Fusarium solani (one of the main pathogenic fungi causing S. baicalensis root rot), and to clarify its antifungal mechanism. We evaluated the toxicity of indole-3-carboxaldehyde to F. solani using the growth rate assay and found that the EC50 value was 59.563 μg/mL; we also performed

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3

Rao, A. R. Balavardhana, and Samudranil Pal. "Cyclopalladation of indole-3-carboxaldehyde aroylhydrazones." Journal of Organometallic Chemistry 696, no. 13 (2011): 2660–64. http://dx.doi.org/10.1016/j.jorganchem.2011.03.033.

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4

Naskar, Subhendu, Abhijit Hazra, Priyankar Paira, Krishnendu B. Sahu, Sukdeb Banerjee, and Nirup B. Mondal. "NH4Cl-Promoted Synthesis of Symmetrical and Unsymmetrical Triindolylmethanes Under Solvent-Free Conditions." Journal of Chemical Research 2008, no. 10 (2008): 568–71. http://dx.doi.org/10.3184/030823408x361101.

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The synthesis of various triindolylmethanes from indole-3-carboxaldehyde, using indole derivatives as reactants and NH4Cl as catalyst under solvent-free conditions, is described. This methodology provides access to both symmetrical and unsymmetrical triindolylmethanes in excellent yields. With N-methylindole particularly, indole-3-carboxaldehyde appears to act as a formyl donor, leading to the exclusive formation of a symmetrically trisubstituted product. The novelty of the methodology lies in its operational simplicity, environment friendly reaction conditions, and inexpensive and easy availa

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5

Wang, Jieqiong, Weifeng Yan, Xu Cheng, Yonggang Tong, Sihong Wang, and Chunmei Jin. "The Intestinal Barrier Protective Effect of Indole Aldehyde Derivatives on Acute Toxoplasma gondii Infection." Molecules 29, no. 21 (2024): 5024. http://dx.doi.org/10.3390/molecules29215024.

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Toxoplasmosis, a zoonotic infection caused by Toxoplasma gondii (T. gondii), poses a significant risk to human health and public safety. Despite the availability of clinical treatments, none effectively mitigate the intestinal barrier damage, which is the primary defense against T. gondii invasion. This study introduced aldehyde groups into the indole scaffold of a peptide-like structure to investigate the protective effects of these indole aldehyde derivatives on the intestinal barrier in mice with acute T. gondii infection. This approach leveraged the propensity of peptides and aldehyde grou

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6

Lakshmi Reddy, Vanammoole, Parvathaneni Sai Prathima, Vaidya Jayathirtha Rao, and Raktani Bikshapathi. "An efficient synthesis of versatile synthon 3-chlorooxindoles with NaCl/oxone." New Journal of Chemistry 42, no. 24 (2018): 20152–55. http://dx.doi.org/10.1039/c8nj04855j.

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7

Morteza, Shiri, and Bozorgpour‑Savadjani Zahra. "Highly selective base-catalyzed ring closing Ugi-adducts from the reaction of 2-formylindole, 2-bromoacetic acid, amines and isocyanides." Journal of the Iranian Chemical Society 12, no. 3 (2014): 389–96. https://doi.org/10.1007/s13738-014-0495-6.

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The intermediate products of the Ugi reaction between indole-2-carboxaldehyde, 2bromoacetic acid, amines and isocyanides were treated with Cs2CO3 in DMF to form a series of novel cyclized 1,2-dihydropyrazino[1,2a]indol-3(4H)-ones (indole –NH cyclization) as major and piperazin-2-ones (amide –NH cyclization) as minor products.

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8

Liu, Xiang-Hong, Feng-Ping Miao, Xiao-Dong Li, Xiu-Li Yin, and Nai-Yun Ji. "A New Sesquiterpene from an Endophytic Aspergillus versicolor Strain." Natural Product Communications 7, no. 7 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700702.

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A new sesquiterpene, albican-11,14-diol (1), and seven known compounds, including sterigmatocystin (2), 3-hydroxy-5-(hydroxymethyl)-4-(4′-hydroxyphenoxy) pyrrolidin-2-one (3), (1 H-indol-3-yl) oxoacetamide (4), indole-3-carboxylic acid (5), indole-3-acetic acid (6), indole-3-carboxaldehyde (7), and volemolide (8), were isolated from the cultures of Aspergillus versicolor, an endophytic fungus isolated from the marine green alga Codium fragile. The structure of 1 was elucidated by 1D, 2D NMR and mass spectroscopic techniques. The bioassay results showed that 1 possessed potent activity against

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9

Gómez-Betancur, Isabel, Jianping Zhao, Lin Tan, et al. "Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities." Marine Drugs 17, no. 7 (2019): 401. http://dx.doi.org/10.3390/md17070401.

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Marine organisms are recognized as a source of compounds with interesting biological activities. Vibrio neocaledonicus has been reported on for its high effectiveness against corrosion in metals but it has been little studied for its chemical and biological activities. In this study, four compounds were isolated from V. neocaledonicus: indole (1); 1H-indole-3-carboxaldehyde (2); 4-hydroxybenzaldehyde (3) and Cyclo (-Pro-Tyr) (4); using a bioassay-guided method, since in a previous study it was found that the ethyl acetate extract was active on the enzymes acetylcholinesterase (AChE), alpha-glu

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10

Shatova, O. P., A. V. Shestopalov, E. Yu Zlatnik, I. A. Novikova, A. S. Goncharova, and A. Yu Maksimov. "The effect of fecal microbiota transplantation on levels of tryptophan metabolites in intestine and serum of gnotobiotic mice." Biomeditsinskaya Khimiya 71, no. 3 (2025): 209–16. https://doi.org/10.18097/pbmcr1554.

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Gut microbiota is one of the key suppliers of tryptophan metabolites, which perform various functions in the host organism, including their role as signaling molecules. Fecal microbiota transplantation (FMT) is widely used as a method for determining the contribution of microorganisms to the content of various metabolites in the holoorganism. In this regard, the aim of our study was to investigate the effect of FMT on the level of tryptophan metabolites in feces and blood in gnotobiotic mice. It was found that both before and after FMT, indole-3-lactate, and quinolinic acid were the dominant t

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11

KURŞUN, Orçun Erdem, Sibel SÜZEN, and Özlem YILDIRIM. "ALTERATIONS OF ALDOSE REDUCTASE ACTIVITY BY INDOLE-3-CARBOXALDEHYDE DERIVATIVES." Communications Faculty of Science University of Ankara Series C Biology Geological Engineering and Geophysical Engineering 30, no. 1 (2021): 13–24. http://dx.doi.org/10.53447/communc.798355.

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In diabetic conditions, aldose reductase (AR, EC 1.1.1.21) activity is significantly increased in lens, kidney and nerve tissues. Mainly in ocular and neural tissues increased levels of sorbitol is associated with diabetic complications such as retinopathy, nephropathy, neuropahty, cataract formation and also tissue damage via increased reactive oxygen speices. Recently, there are many studies that show the relationship between this enzyme family and cancer. Aldose reductase is important for the pathway and in turn has been a potential target for drug design. Great number of aldose reductase i

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12

Neochoritis, Constantinos G., Maryam Kazemi Miraki, Eman M. M. Abdelraheem, et al. "Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists." Beilstein Journal of Organic Chemistry 15 (February 20, 2019): 513–20. http://dx.doi.org/10.3762/bjoc.15.45.

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Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F19W23L25. The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclization. The reaction of 12 different α,ω-amino acids and different indole-3-carboxaldehyde derivatives afforded a unique library of macrocycles otherwise difficult to access. Screening of the library for p53-MDM2 inhibition by fluorescence polarization and 1H,15N HSQC NMR measurements confirm MDM2 binding.

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13

Baláž, Matej, Zuzana Kudličková, Mária Vilková, Ján Imrich, Ľudmila Balážová, and Nina Daneu. "Mechanochemical Synthesis and Isomerization of N-Substituted Indole-3-carboxaldehyde Oximes †." Molecules 24, no. 18 (2019): 3347. http://dx.doi.org/10.3390/molecules24183347.

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Performing solution-phase oximation reactions with hydroxylamine hydrochloride (NH2OH·HCl) carries significant risk, especially in aqueous solutions. In the present study, four N-substituted indole-3-carboxaldehyde oximes were prepared from the corresponding aldehydes by solvent-free reaction with NH2OH·HCl and a base (NaOH or Na2CO3) using a mechanochemical approach, thus minimizing the possible risk. In all cases, the conversion to oximes was almost complete. The focus of this work is on 1-methoxyindole-3-carboxaldehyde oxime, a key intermediate in the production of indole phytoalexins with

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14

Zhao, Xuejin, Lianzhong Zhao, Ya Zhao, et al. "3-Indoleacetonitrile Is Highly Effective in Treating Influenza A Virus Infection In Vitro and In Vivo." Viruses 13, no. 8 (2021): 1433. http://dx.doi.org/10.3390/v13081433.

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Influenza A viruses are serious zoonotic pathogens that continuously cause pandemics in several animal hosts, including birds, pigs, and humans. Indole derivatives containing an indole core framework have been extensively studied and developed to prevent and/or treat viral infection. This study evaluated the anti-influenza activity of several indole derivatives, including 3-indoleacetonitrile, indole-3-carboxaldehyde, 3-carboxyindole, and gramine, in A549 and MDCK cells. Among these compounds, 3-indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A virus

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15

Devys, Michel, and Michel Barbier. "Indole-3-carboxaldehyde in the cabbage Brassica oleracea: A systematic determination." Phytochemistry 30, no. 2 (1991): 389–91. http://dx.doi.org/10.1016/0031-9422(91)83690-m.

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16

Halawa, Ahmed H., Ahmed H. Bedair, Ahmed M. El-Agrody, et al. "Synthesis and biological activities of new bis-indole derivatives via microwave irradiation." Zeitschrift für Naturforschung B 72, no. 9 (2017): 639–46. http://dx.doi.org/10.1515/znb-2017-0039.

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AbstractThree new series of bis-indole derivatives were synthesized based onp-phenylenediamine (2–4, 5and6) and 4,4′-ethylenedianiline moieties (7–9) using facile and efficient condensation of three positional isomeric indole-carboxaldehyde derivatives (1a–c) with bifunctional amines upon microwave irradiation. The symmetric dimeric indole derivatives2–4as well as non-symmetric analogues5and6were obtained byin situcondensation of the respective positional 3-, 2- and 5-isomeric indole-carboxaldehydes withp-phenylenediamine, while compounds7–9resulted from respective condensation based on 4,4′-e

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17

Yin, Jia, Yujie Song, Yaozhong Hu, et al. "Dose-Dependent Beneficial Effects of Tryptophan and Its Derived Metabolites on Akkermansia In Vitro: A Preliminary Prospective Study." Microorganisms 9, no. 7 (2021): 1511. http://dx.doi.org/10.3390/microorganisms9071511.

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Akkermansia muciniphila, a potential probiotic, has been proven to lessen the effects of several diseases. As established, the relative abundance of Akkermansia is positively correlated with tryptophan metabolism. However, the reciprocal interaction between tryptophan and Akkemansia is still unclear. Herein, for the first time, the possible effects of tryptophan and its derived metabolites on A. muciniphila were preliminarily investigated, including growth, physiological function, and metabolism. Obtained results suggested that 0.4 g/L of tryptophan treatment could significantly promote the gr

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18

Kirsch, Gilbert, Eslam El-Sawy, and Ahmed Abdelwahab. "Utilization of 1H-Indole-3-carboxaldehyde as a Precursor for the Synthesis of Bioactive Indole Alkaloids." Synthesis 50, no. 23 (2018): 4525–38. http://dx.doi.org/10.1055/s-0037-1610288.

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Indole alkaloids constitute a large class of natural products and their diverse and complex structures have been attributed to potent biological activities such as anticancer, anti-inflammatory, antimicrobial, antimalarial, antiplasmodial and protein kinase inhibition. The isolation of bioactive compounds from natural sources is difficult, costly and an extremely time-consuming process, therefore synthetic pathways are more convenient than natural separation to deliver such compounds in considerable amounts. In this respect, this review provides comprehensive information on the structures and

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19

Rajeev, Jain, and Bhadauria Akhilesh. "Synthesis ·of some biologically important hydrazono and azomethine compounds." Journal of Indian Chemical Society Vol. 84, Feb 2007 (2007): 197–99. https://doi.org/10.5281/zenodo.5814795.

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School of Studies in Chemistry, Jiwaji University, Gwalior-474 011, Madhya Pradesh, India <em>E-mail</em> : gwlsosmica@sancharnet. in <em>Fax</em>: 91-751-346209 <em>Manuscript received 16 February 2004, revised 12 October 2006, accepted 12 December 2006</em> 2-(4'-Sulphonamoylphenyl)hydrazonoindane-1,3-diones (la-e) were synthesized by coupling indanc-1,3-dionc with diazotized sulphonamides. 3-(4' -Sulphonamoylphenyl) azomethineindoles (2a-e) and 3- aminobenzothiazolyl) azomethineindole (3) were synthesised by refluxing indole-3-carboxaldehyde with sulfonamide derivatives and 3- amino

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20

Suzdalev, Konstantin F., Sophia V. Den’kina, Alena A. Starikova, Vladimir V. Dvurechensky, Mikhail E. Kletsky, and Oleg N. Burov. "Reaction of 1-(oxiran-2-ylmethyl)-1H-indole-3-carboxaldehyde with amines." Mendeleev Communications 21, no. 4 (2011): 231–33. http://dx.doi.org/10.1016/j.mencom.2011.07.021.

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21

Cravotto, Giancarlo, Giovanni B. Giovenzana, Angelo Maspero, Tullio Pilati, Andrea Penoni, and Giovanni Palmisano. "Allylindation of 1H-indole-3-carboxaldehyde in the presence of azoles—revisited." Tetrahedron Letters 47, no. 36 (2006): 6439–43. http://dx.doi.org/10.1016/j.tetlet.2006.06.124.

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22

Cortés C., Eduardo, Roberto Martinez, and Martha B. Gutierrez Gomez. "Mass spectra of some 2-(p-R2-phenyl)-indole-3-carboxaldehyde derivatives." Organic Mass Spectrometry 26, no. 8 (1991): 695–96. http://dx.doi.org/10.1002/oms.1210260805.

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23

Xue, Jing. "Synthesis of Deuterated 1H-Indole-3-carboxaldehyde via Catalytic Vilsmeier-Haack Reaction." Organic Syntheses 101 (2024): 21–33. http://dx.doi.org/10.15227/orgsyn.101.0021.

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24

Loboda, Mariia, Liudmyla Biliavska, Galyna Iutynska, Jake Newitt, and Ruslan Mariychuk. "Natural Products Biosynthesis by Streptomyces netropsis IMV Ac-5025 under Exogenous Sterol Action." Antibiotics 13, no. 2 (2024): 146. http://dx.doi.org/10.3390/antibiotics13020146.

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Streptomycetes are known as producers of bioactive substances, particularly antibiotics. Streptomyces netropsis IMV Ac-5025 simultaneously produces different classes of antibiotics, including polyene compounds, phytohormones, and sterols, but the metabolic pathways involved in their biosynthesis are largely understudied. The aim of this work was to explore the biosynthesis of polyene antibiotics, sterols, and phytohormones when the producer is cultivated in a nutrient medium supplemented with exogenous β-sitosterol. Gas chromatography and high-performance liquid chromatography were applied to

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25

Z, Shamna S. Greeshma A. Sumathy N. L. Gowrishankar. "Synthesis Of Schiff Bases Of Indole-3-Carboxaldehyde Derivatives Using Biginelli Reaction And Their Antioxidant Evaluation." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 218–23. https://doi.org/10.5281/zenodo.13893972.

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A series of Schiff bases of  indole-3-carboxaldehyde were synthesized using biginelli reaction and examined for their antioxidant potential to probe the most potent analogues using two in vitro models like 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Through the compounds showed various degree of activity whereas, compound (DP-2 and DP-4) shows superior antioxidant activity relative to other examined derivatives and also exhibit more activity than the standard, Ascorbic acid (AA).

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26

M., A. Neelakantan, Rusal Raj F., and Sankaranarayana Pillai M. "Spectroscopy, electrochemistry and biocidal activity of amino acid Schiff base metal complexes." Journal of Indian Chemical Society Vol. 85, Jan 2008 (2008): 100–104. https://doi.org/10.5281/zenodo.5808598.

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Department of Chemistry, National Engineering College, K. R. Nagar, Kovilpatti-628 503, Tamilnadu, India Department of Chemistry, S. T. Hindu College, Nagercoil-629 002, Tamilnadu, India E-mail : drma_neelakantan@yahoo.com Manuscript received 25 July 2007, revised 12 October 2007, accepted 12 October 2007 <strong>Cu<sup>II</sup> , Ni<sup>II</sup> , Zn<sup>II</sup> , Co<sup>II</sup> , Mn<sup>II</sup></strong> and<strong> VO<sup>II</sup></strong> Schiff base complexes derived from indole-3-carboxaldehyde (<strong>lnd</strong>) and amino acids viz. L-alanine (ala), L-phenylalanine (pala) and L-hi

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27

Shirinzadeh, Hanif, Ayse Didem Yilmaz, Mehmet Gumustas, Sibel Suzen, Seckin Ozden, and Sibel A. Ozkan. "Electrochemical Behavior of Indole-3-Carboxaldehyde Izonicotinoyl Hydrazones: Discussion on Possible Biological Behavior." Combinatorial Chemistry & High Throughput Screening 13, no. 7 (2010): 619–27. http://dx.doi.org/10.2174/1386207311004070619.

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28

Sinha, Deepa, Anjani K. Tiwari, Sweta Singh, et al. "Synthesis, characterization and biological activity of Schiff base analogues of indole-3-carboxaldehyde." European Journal of Medicinal Chemistry 43, no. 1 (2008): 160–65. http://dx.doi.org/10.1016/j.ejmech.2007.03.022.

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29

Cortés C., Eduardo, Roberto Martínez, and José I. Ramírez. "Mass spectra of some 2-(o-R1-phenyl)-indole-3-carboxaldehyde derivatives. II." Organic Mass Spectrometry 26, no. 12 (1991): 1095–96. http://dx.doi.org/10.1002/oms.1210261213.

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30

Sengar, S., S. K. Singh, and M. K. Gupta. "Design and synthesis of iron(II) complexes with Schiff bases derived from 6-aminopenicillanic acid and heterocyclic aldehydes." Research Journal of Chemistry and Environment 26, no. 4 (2022): 163–66. http://dx.doi.org/10.25303/2604rjce163166.

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The reaction of iron (II) acetate with Schiff bases derived from the condensation reaction of benzaldehyde or indole-3-carboxaldehyde with (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1azabi cyclo[3.2.0] hepta -ne-2-carboxylic acid (6- Aminopenicillanic Acid) in 1:1 molar ratio gave a new series of iron(II) complexes. The coordination bond formation behaviour of Schiff bases with iron atom has been characterised by elemental analysis, conductance measurements, molecular weight determinations, IR, UV and 1H NMR spectral studies.

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31

Reshetova, Maria, Pavel Markin, Svetlana Appolonova, et al. "Tryptophan Metabolites in the Progression of Liver Diseases." Biomolecules 14, no. 11 (2024): 1449. http://dx.doi.org/10.3390/biom14111449.

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The aim of this study was to investigate the levels of various tryptophan metabolites in patients with alcoholic liver disease (ALD) and metabolic-associated fatty liver disease (MAFLD) at different stages of the disease. The present study included 44 patients diagnosed with MAFLD, 40 patients diagnosed with ALD, and 14 healthy individuals in the control group. The levels of tryptophan and its 16 metabolites (3-OH anthranilic acid, 5-hydroxytryptophan, 5-methoxytryptamine, 6-hydroxymelatonin, indole-3-acetic acid, indole-3-butyric, indole-3-carboxaldehyde, indole-3-lactic acid, indole-3-propio

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32

Deletioğlu, Didem, Erdoğan Hasdemir, Ali Osman Solak, Zafer Üstündağ, and Remziye Güzel. "Preparation and characterization of poly(indole-3-carboxaldehyde) film at the glassy carbon surface." Thin Solid Films 519, no. 2 (2010): 784–89. http://dx.doi.org/10.1016/j.tsf.2010.07.125.

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33

Joseph, Benoît, Charlène Sagnes, and Guy Fournet. "Unexpected C2-Arylation of 1-(Pyridin-2-yl)indole-3-carboxaldehyde Mediated by Copper." Synlett 2009, no. 03 (2009): 433–36. http://dx.doi.org/10.1055/s-0028-1087549.

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Suzdalev, Konstantin F., Sophia Den'kina, Alena A. Starikova, Vladimir V. Dvurechensky, Mikhail E. Kletsky, and Oleg N. Burov. "ChemInform Abstract: Reaction of 1-(Oxiran-2-ylmethyl)-1H-indole-3-carboxaldehyde with Amines." ChemInform 42, no. 50 (2011): no. http://dx.doi.org/10.1002/chin.201150092.

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35

Cortés C., Eduardo, Eduardo Cortés R., and Hortensia Arreguín B. "Mass spectra of some 2-(o-andp-R1-phenyl)-indole-3-carboxaldehyde derivatives. III." Organic Mass Spectrometry 27, no. 8 (1992): 901–2. http://dx.doi.org/10.1002/oms.1210270810.

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36

M., Sivasankaran Nair, Ravi Samuel Raj C., and Selwin Joseyphus R. "Computational study on imidazole-2-carboxaldehyde-glycylglycine and indole-3- carboxaldehyde-glycylglycine Schiff base ligands and equilibrium studies on their metal complexes." Journal of Indian Chemical Society Vol. 87, Jun 2010 (2010): 655–60. https://doi.org/10.5281/zenodo.5788515.

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Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627 012, Tamilnadu, India <em>E-mail:</em> msnairchem@rediffmail.com <em>Manuscript received 13 April 2009, revised 5 October 2009, accepted 17 November 2009</em> Semiempirical (AMI) calculations were carried out for the Schiff bases, imidazole-2-carboxaldehyde-glycylgilycine (imal-glygly) and lndole-3-carboxaldehyde-glycylglycine (indal-glygly). Five conformers or imal-glygly and indal-glygly suitable for complex formation were studied. The stable conformers were chosen for further studies. The geometrical parameters

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37

Halawa, Ahmed H., Shimaa Mohamed Abd El-Gilil, Ahmed H. Bedair, et al. "Synthesis, biological activity and molecular modeling study of new Schiff bases incorporated with indole moiety." Zeitschrift für Naturforschung C 72, no. 11-12 (2017): 467–75. http://dx.doi.org/10.1515/znc-2017-0025.

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AbstractA new series of heterocyclic Schiff bases2–9containing indole moiety were synthesized by facile and efficient condensation of indole-3/2/5-carboxaldehyde (1a/1b/1c) with different aromatic and heterocyclic primary amines using conventional and/or microwave irradiation methods. The structures of the obtained compounds were assigned by sophisticated spectroscopic and spectrometric techniques (1D-NMR, 2D-NMR and MS). The synthesized compounds were screened for their cytotoxicity and antibacterial activities. In vitro cytotoxicity screening revealed that compound5exhibited moderate activit

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38

Shestopalov, A. V., O. P. Shatova, M. S. Karbyshev, et al. "“Kynurenine switch” and obesity." Bulletin of Siberian Medicine 20, no. 4 (2022): 103–11. http://dx.doi.org/10.20538/1682-0363-2021-4-103-111.

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Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods. Using high-performance liquid chromatography with mass spectrometric detection, the concentrations of several serum metabolites, such as kynurenine, kynurenic acid, anthranilic acid, xanthurenic acid, quinolinic acid, 5-hydroxyindole-3-acetate, tryptamine, serotonin, indole-3-lactate, indole-3-acetate, indole-3- butyrate, indole-3-carboxaldehyde, indole-3-acrylate, and indole

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39

Ma, Bingyang, Yan Zhao, Liping Liu, et al. "Evaluation of In Vitro Production Capabilities of Indole Derivatives by Lactic Acid Bacteria." Microorganisms 13, no. 1 (2025): 150. https://doi.org/10.3390/microorganisms13010150.

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Lactic acid Bacteria (LAB) convert tryptophan to indole derivatives and induce protective IL-22 production in vivo. However, differences in metabolizing capabilities among LAB species have not been widely investigated. In the present study, we compared the capabilities of 186 LAB strains to produce four kinds of indole derivatives, including indole-3-carboxaldehyde (IAId), indole-3-lactic acid (ILA), indole-3-propanoic acid (IPA), and indole-3-acetic acid (IAA). These strains were isolated from fermented foods, dairy products, and the feces of healthy individuals, as well as from fish and shri

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Alfieri, Maria Laura, Lucia Panzella, Marco d’Ischia, and Alessandra Napolitano. "Bioinspired Heterocyclic Partnership in a Cyanine-Type Acidichromic Chromophore." Molecules 25, no. 17 (2020): 3817. http://dx.doi.org/10.3390/molecules25173817.

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A new red hair-inspired 1,4-benzothiazine-based scaffold is disclosed herein, built upon a modular D-π-A architecture via condensation of the easily accessible 3-phenyl-2H-1,4-benzothiazine with indole-3-carboxaldehyde. The compound was obtained in around 50% yields and was characterized by complete spectroscopic analysis. The new benzothiazine-based cyanine displayed a characteristic reversible acidichromic behavior with a marked bathochromic shift upon acidification. The chromophore resisted at least fifteen hydrochloric acid/sodium hydroxide cycles without appreciable alterations. The exped

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L., Krishnakumar K., Mathew Paul Ukken та Manju R. "A STUDY ON EFFECT OF INDOLE AS A SUBSTITUENT ON A KETO-ENOL TAUTOMER: A SYNTHETIC APPROACH ON β-DIKETONE". International Journal of Pharmacy and Pharmaceutical Sciences 9, № 8 (2017): 219. http://dx.doi.org/10.22159/ijpps.2017v9i8.19576.

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Objective: The existence of keto-enol tautomerism in β-diketones can typically study by a choice of analytical technique. The position of the keto-enol equilibrium depends on a number of factors like solvent, temperature, and substituents. Here an attempt was made to examine the effect of indole, a heterocyclic moiety with the moderately high polar surface area to examine its effect on ketonisation of β-diketone.Methods: The β-diketone studied and synthesized is a structural analog of magical drug curcumin. The structural influence of indole on ketonisation of β-diketone is studied to give a h

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Jeyaseelan, S. Christopher, and A. Milton Franklin Benial. "Quantum chemical, spectroscopic investigations, molecular docking and cytotoxic evaluation of 1-Methyl-indole-3-carboxaldehyde." Chemical Data Collections 33 (June 2021): 100698. http://dx.doi.org/10.1016/j.cdc.2021.100698.

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Liu, Xinlei, Rui Liu, and Yancheng Wang. "Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis." Biochemical and Biophysical Research Communications 710 (May 2024): 149880. http://dx.doi.org/10.1016/j.bbrc.2024.149880.

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Oruma, Uchechukwu Susan, Pius Oziri Ukoha, Nkechinyere Nwanneka Ukwueze, et al. "Synthesis, Biological and In Silico Studies of (1H-Indol-3-ylmethylene)-naphthalen-1-ylamine and its Os(VIII), Pd (II), Ni(II), Cr (III) and Fe(III) Complexes." Oriental Journal Of Chemistry 40, no. 6 (2024): 1715–22. https://doi.org/10.13005/ojc/400624.

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(1H-Indol-3-ylmethylene)-naphthalen-1-ylamine, INDNA was synthesized by the condensation of 1- naphthylamine with indole-3-carboxaldehyde. Additionally, the complexes of Os(VIII), Pd (II), Ni(II), Cr (III) and Fe(III) were synthesized. ESI-MS spectroscopic techniques, 1H and 13C NMR, UV-VIS, IR and elemental analysis were used to characterize the ligand and metal complexes. According to spectral data, INDNA binds as a bidentate ligand to the metal ions via the nitrogens in the imine and indole chains. The ligand to metal stoichiometry of the compounds is 2:1. The metal complexes exhibit tetrah

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Flakus, Henryk T., Barbara Hachuła, and Aleksandra Pyzik. "The hydrogen bond IR spectra of indole-3-carboxaldehyde and 3-acetylindole crystals – The reason behind their similarity." Chemical Physics 379, no. 1-3 (2011): 73–82. http://dx.doi.org/10.1016/j.chemphys.2010.11.008.

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Swimm, Alyson, Cynthia R. Giver, Zachariah DeFilipp, et al. "Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease." Blood 132, no. 23 (2018): 2506–19. http://dx.doi.org/10.1182/blood-2018-03-838193.

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Abstract The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the intestinal microbiota limit intestinal inflammation caused by diverse stressors, so we tested their capacity to protect against GVHD in murine major histocompatibility complex–mismatched models of allo-BMT. Indole effects were assessed by colonization of allo-BMT recipient mi

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D’Onofrio, Fiorella, Giorgia Renga, Matteo Puccetti, et al. "Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis." Cells 10, no. 7 (2021): 1622. http://dx.doi.org/10.3390/cells10071622.

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Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indol

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Zahran, Magdy A., Hanan M. Afify, Erik B. Pedersen, and Claus Nielsen. "Synthesis of 1-substituted indole-3-carboxaldehyde related to acyclic nucleosides and their condensed pyrenyl derivatives." Journal of Chemical Research 2001, no. 1 (2001): 9. http://dx.doi.org/10.3184/030823401103168244.

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Cao, Ji, Qiuyu Bao, and Haiping Hao. "Indole-3-Carboxaldehyde Alleviates LPS-Induced Intestinal Inflammation by Inhibiting ROS Production and NLRP3 Inflammasome Activation." Antioxidants 13, no. 9 (2024): 1107. http://dx.doi.org/10.3390/antiox13091107.

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Indole-3-carboxaldehyde (IAld) is a tryptophan (Trp) metabolite derived from gut microbiota, which has a potential protective effect on intestinal inflammatory diseases. Abnormal activation of NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is an important cause of intestinal inflammation. However, the effect and mechanism of IAld on NLRP3 inflammasome activation remain unclear. Here, we found that IAld inhibited the activation of the NLRP3 inflammasome in intestinal epithelial cells, and effectively prevented intestinal epithelial barrier injury caused by lipopolysacch

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Tollari, Stefano, Giovanni Palmisano, Francesco Demartin, Maria Grassi, Stefano Magnaghi, and Sergio Cenini. "Synthesis, X-ray structure and reactivity of cyclopalladated complexes of hydrazones of 1H-indole-3-carboxaldehyde." Journal of Organometallic Chemistry 488, no. 1-2 (1995): 79–83. http://dx.doi.org/10.1016/0022-328x(94)05113-p.

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